DISEASE MODEL AND USE THEREOF

Title:

DISEASE MODEL AND USE THEREOF

Document Type and Number:

WIPO Patent Application WO/2023/246838

Kind Code:

A1

Abstract:

Provided is a disease model and use thereof. In particular, provided is an engineered human cell with a mutated APP gene, a cellular model derived from the engineered human cell and use thereof.

Inventors:

LU BAI (CN)
LIU HANG (CN)
GUAN XIAOMING (CN)

Application Number:

PCT/CN2023/101589

Publication Date:

December 28, 2023

Filing Date:

June 21, 2023

Export Citation:

Click for automatic bibliography generation Help

Assignee:

UNIV TSINGHUA (CN)
4B TECH BEIJING CO LIMITED (CN)

International Classes:

C12N5/071; C07K14/47

Domestic Patent References:

WO2022080820A1

2022-04-21

Foreign References:

US20030056231A1	2003-03-20
US5850003A	1998-12-15

Other References:

DATABASE Protein 17 May 2020 (2020-05-17), ANONYMOUS : "amyloid-beta precursor protein isoform a precursor [Homo sapiens] ", XP093119884, retrieved from NCBI Database accession no. NP_000475.1
FAN W. ET AL.: "Optimized duplex PCR sets in the identification of APPSWE Transgenic mice", CHINESE JOURNAL OF NEUROANATOMY, vol. 25, no. 1, 31 January 2009 (2009-01-31), XP009551366
D'SOUZA GARY X., ROSE SHANNON E., KNUPP ALLISON, NICHOLSON DANIEL A., KEENE CHRISTOPHER DIRK, YOUNG JESSICA E.: "The application of in vitro ‐derived human neurons in neurodegenerative disease modeling", JOURNAL OF NEUROSCIENCE RESEARCH, WILEY-LISS, US, vol. 99, no. 1, 1 January 2021 (2021-01-01), US , pages 124 - 140, XP093119943, ISSN: 0360-4012, DOI: 10.1002/jnr.24615

Attorney, Agent or Firm:

SHANGHAI DIANSHI PARTNERS , P.C. et al. (CN)

Download PDF:

View/Download PDF PDF Help

Previous Patent: CLASS OF COMPOUNDS HAVING PYRIMIDO-SIX-MEMBERED RING STRUCTURE, PHARMACEUTICAL COMPOSITIONS COMPRISI...

Next Patent: SALT OF THIENO[2,3-D]IMIDAZOLE COMPOUND, CRYSTAL FORM THEREOF AND PHARMACEUTICAL USE THEREOF