Title:
CLASS OF MORPHOLINE DERIVATIVES, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/152229
Kind Code:
A1
Abstract:
A class of morpholine derivatives represented by formula (I) and compositions comprising the morpholine derivatives. The compounds have excellent ATR inhibitory effects and functions, and can be used to prepare a drug for treating and/or preventing a related disease mediated by ATR. The related disease mediated by ATR is selected from cancer or hyperproliferative diseases.
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Inventors:
WANG WEI (CN)
ZENG HONG (CN)
GONG XIAOMING (CN)
ZHU WANQU (CN)
XIE HONGLEI (CN)
WANG YING (CN)
PAN DESI (CN)
LI ZHIBIN (CN)
LU XIANPING (CN)
ZENG HONG (CN)
GONG XIAOMING (CN)
ZHU WANQU (CN)
XIE HONGLEI (CN)
WANG YING (CN)
PAN DESI (CN)
LI ZHIBIN (CN)
LU XIANPING (CN)
Application Number:
PCT/CN2022/071909
Publication Date:
July 21, 2022
Filing Date:
January 14, 2022
Export Citation:
Assignee:
SHENZHEN CHIPSCREEN BIOSCIENCES CO LTD (CN)
CHENGDU CHIPSCREEN PHARMACEUTICAL LTD (CN)
CHENGDU CHIPSCREEN PHARMACEUTICAL LTD (CN)
International Classes:
C07D495/04; A61K31/5375; A61P35/00; C07D487/04
Domestic Patent References:
| WO2010136491A1 | 2010-12-02 |
Foreign References:
| CN106831812A | 2017-06-13 | |||
| CN101675053A | 2010-03-17 | |||
| CN101600720A | 2009-12-09 | |||
| CN102341108A | 2012-02-01 |
Other References:
LU YIPIN; KNAPP MARK; CRAWFORD KENNETH; WARNE ROBERT; ELLING ROBERT; YAN KELLY; DOYLE MICHAEL; PARDEE GWYNN; ZHANG LI; MA SYLVIA; : "Rationally Designed PI3Kα Mutants to Mimic ATR and Their Use to Understand Binding Specificity of ATR Inhibitors", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 429, no. 11, 20 April 2017 (2017-04-20), United Kingdom , pages 1684 - 1704, XP085041884, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2017.04.006
LEE WENDY; ORTWINE DANIEL F.; BERGERON PHILIPPE; LAU KEVIN; LIN LICHUAN; MALEK SHIVA; NONOMIYA JIM; PEI ZHONGHUA; ROBARGE KIRK D.;: "A hit to lead discovery of novelN-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 23, no. 18, 23 July 2013 (2013-07-23), Amsterdam NL , pages 5097 - 5104, XP028694525, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.07.027
LEE WENDY; ORTWINE DANIEL F.; BERGERON PHILIPPE; LAU KEVIN; LIN LICHUAN; MALEK SHIVA; NONOMIYA JIM; PEI ZHONGHUA; ROBARGE KIRK D.;: "A hit to lead discovery of novelN-methylated imidazolo-, pyrrolo-, and pyrazolo-pyrimidines as potent and selective mTOR inhibitors", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ELSEVIER, AMSTERDAM NL, vol. 23, no. 18, 23 July 2013 (2013-07-23), Amsterdam NL , pages 5097 - 5104, XP028694525, ISSN: 0960-894X, DOI: 10.1016/j.bmcl.2013.07.027
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