Title:
CLOSTRIDIUM DIFFICILE ANTIGENS
Document Type and Number:
WIPO Patent Application WO/2012/092469
Kind Code:
A3
Abstract:
Compositions and methods for the treatment or prevention of Clostridium difficile infection in a vertebrate subject are provided. The methods provide administering a composition to the vertebrate subject in an amount effective to reduce or eliminate or prevent relapse of Clostridium difficile bacterial infection and/or induce an immune response to the protein. Methods for the treatment or prevention of Clostridium difficile infection in a vertebrate are also provided.
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Inventors:
BERRY JODY (US)
JOHNSTONE DARRELL (CA)
TIGHE BONNIE (CA)
LOPEZ MARIANELA (CA)
GEORGE JOYEE (CA)
HAN XIAOBING (CA)
JOHNSTONE DARRELL (CA)
TIGHE BONNIE (CA)
LOPEZ MARIANELA (CA)
GEORGE JOYEE (CA)
HAN XIAOBING (CA)
Application Number:
PCT/US2011/067806
Publication Date:
September 07, 2012
Filing Date:
December 29, 2011
Export Citation:
Assignee:
CANGENE CORP (CA)
BERRY JODY (US)
JOHNSTONE DARRELL (CA)
TIGHE BONNIE (CA)
LOPEZ MARIANELA (CA)
GEORGE JOYEE (CA)
HAN XIAOBING (CA)
BERRY JODY (US)
JOHNSTONE DARRELL (CA)
TIGHE BONNIE (CA)
LOPEZ MARIANELA (CA)
GEORGE JOYEE (CA)
HAN XIAOBING (CA)
International Classes:
A61K39/40; C12P21/08; C07K1/00; C07K16/00
Foreign References:
| US20100291100A1 | 2010-11-18 | |||
| US20090087478A1 | 2009-04-02 | |||
| US20080213314A1 | 2008-09-04 | |||
| US20080057047A1 | 2008-03-06 | |||
| US20100233182A1 | 2010-09-16 |
Other References:
LAWLEY ET AL.: "Proteomic and Genomic Characterization of Highly Infectious Clostridium difficile 630 Spores.", J BACTERIOL., vol. 191, no. 17, 2009, pages 5377 - 86, XP002680262
BABCOCK ET AL.: "Human Monodonal Antibodies Directed against Toxins A and B Prevent Clostridium difficile-Induced Mortality in Hamsters.", INFECT IMMUN., vol. 74, no. 11, 2006, pages 6339 - 47, XP009109025
KUEHN ET AL.: "Development of Antibodies against Anthrose Tetrasaccharide for Specific Detection of Bacillus anthracis Spores.", CLIN VACCINE IMMUNOL., vol. 16, no. 12, 2009, pages 1728 - 37, XP055112735
BABCOCK ET AL.: "Human Monodonal Antibodies Directed against Toxins A and B Prevent Clostridium difficile-Induced Mortality in Hamsters.", INFECT IMMUN., vol. 74, no. 11, 2006, pages 6339 - 47, XP009109025
KUEHN ET AL.: "Development of Antibodies against Anthrose Tetrasaccharide for Specific Detection of Bacillus anthracis Spores.", CLIN VACCINE IMMUNOL., vol. 16, no. 12, 2009, pages 1728 - 37, XP055112735
Attorney, Agent or Firm:
DAVITZ, Michael A. (Veltrop & Harkrider LLP114 West 47th Stree, New York NY, US)
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