Title:
CMLCK GENE INTRODUCTION
Document Type and Number:
WIPO Patent Application WO/2016/180377
Kind Code:
A1
Abstract:
The present invention relates to a component and method used for cMLCK gene introduction. Provided are a component and method for treating severe heart failure via cMLCK gene introduction. Specifically, an effective dose of a polynucleotide vector which encodes the cMLCK protein is applied to an individual so as to improve the ventricular function of the heart, said polynucleotide vector encoding the cMLCK protein in heart cells of the individual. Also provided are a component and method for expressing the cMLCK protein in an individual. Specifically, a polynucleotide vector capable of encoding the cMLCK protein is applied to an individual, said vector being capable of expressing the cMLCK protein in heart cells of the individual, said individual suffering from severe heart failure.
Inventors:
ZHOU MINGDONG (AU)
Application Number:
PCT/CN2016/085699
Publication Date:
November 17, 2016
Filing Date:
June 14, 2016
Export Citation:
Assignee:
ZENSUN (SHANGHAI) SCI & TECH CO LTD (CN)
International Classes:
A61K48/00; A61P9/04
Domestic Patent References:
| WO2002024889A2 | 2002-03-28 |
Foreign References:
| JP2009242388A | 2009-10-22 | |||
| CN101553568A | 2009-10-07 |
Other References:
LI, GUANGHAO ET AL.: "A Function of the Rho/ROCK Signal Path in Chronic Congestive Heart Failure", SHANDONG MEDICAL JOURNAL., vol. 53, no. 41, 31 December 2013 (2013-12-31), pages 94 - 96
See also references of EP 3295959A4
See also references of EP 3295959A4
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