CO-CRYSTAL STRUCTURE OF FACTOR D AND ANTI-FACTOR D ANTIBODY

Field of the Invention

The present invention concerns the co-crystal structure of Factor D and an anti-Factor D antibody or an antigen binding fragment thereof.

Background of the Invention

Factor D is a highly specific chymotrypsin-like serine protease that is a rate-limiting enzyme in the activation of the alternative complement pathway. The substrate for Factor D is another alternative pathway serine protease, factor B. Following cleavage by Factor D, factor B converts into the proteolytically active factor Bb and initiates the alternative complement pathway. Increased activation of the alternative complement pathway has been found in drusen. Drusen are cytotoxic complement-containing deposits present on the Bruch's membrane, which are associated with the development of age-related macular degeneration (AMD). A role of alternative pathway complement activation in AMD has further been supported by genetic analysis, showing that a mutation in factor H, a negative regulator of alternative complement pathway activation, is strongly correlated with increased risk for developing AMD.

Anti-Factor D antibodies are disclosed in U.S. Patent Publication Nos. 20080118506, published May 22, 2008; 20090181017, published July 16, 2009; and 20090269338, published October 29, 2009. Anti-Factor D antibodies find utility in the prevention and treatment of diseases and disorders associated with excessive or uncontrolled complement activation, and are useful for diagnostics, prophylaxis and treatment of disease.

Summary of the Invention

The instant disclosure presents the crystal structure of human and cynomolgous Factor D in complex with an anti-Factor D antibody fragment. The invention also provides information about the residues on human and cynomolgous Factor D that interact with the light- and heavy chains of the anti Factor D antibody Fab region.

In one aspect, the invention concerns a crystal formed by a native sequence Factor D polypeptide or a functional fragment or conservative amino acid substitution variant thereof.

In one embodiment, the native sequence Factor D polypeptide is human or cyno Factor

D.

In another embodiment, the native sequence Factor D polypeptide is human Factor D of SEQ ID NO: 1. In yet another embodiment, the crystal of human Factor D is characterized by unit cell parameters approximately equal to the following: cell dimensions a=132.048; b=132.048; c=180.288; space group P4 ₃ 2i2, crystal constant: 2.4A, and R/Rfree=21.2%/27.2.

In a further embodiment, the native sequence Factor D polypeptide is cyno Factor D of SEQ ID NO: 2.

In a still further embodiment, the crystal of cyno Factor D is characterized by unit cell parameters approximately equal to the following: a=l 82.205; b=80.673; c=142.575, space group C2, crystal constant: 2.1 A; and R/Rfree=21.1%/26.9.

In another aspect, the invention concerns a Factor D crystal with the structural coordinates shown in Appendices 1A and IB.

In yet another aspect, the invention concerns a composition comprising any of the foregoing crystals.

In a different aspect, the invention concerns a crystallizable composition comprising a Factor D polypeptide complexed with an anti-Factor D antibody or an antigen binding fragment of said antibody.

In one embodiment, in the cystallizable composition the anti-Factor D antibody is a monoclonal antibody.

In another embodiment, the fragment is a Fab fragment.

In yet another embodiment, in the crystallizable composition the Factor D polypeptide is human Factor D of SEQ ID NO : 1.

In a further embodiment, in the crystallizable composition the Factor D polypeptide is cyno Factor D of SEQ ID NO: 2.

In a still further embodiment, the Factor D polypeptide comprises a catalytic triad.

In a further aspect, the invention concerns a crystal comprising a Factor D polypeptide complexed with an anti-Factor D antibody or an antigen binding fragment thereof.

In one embodiment, the antibody is a monoclonal antibody.

In another embodiment, the fragment is a Fab fragment.

In yet another embodiment, the Factor D polypeptide is human Factor D of SEQ ID NO:

1.

In a further embodiment, the Factor D polypeptide is cyno Factor D of SEQ ID NO: 2.

In a still further embodiment, the Factor D polypeptide comprises a catalytic triad.

In another embodiment, in the human Factor D polypeptide of SEQ ID NO: 1, or antigen binding fragment thereof, one or more of amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 participate in complexing with the anti-Factor D antibody.

In yet another embodiment, in the human Factor D polypeptide of SEQ ID NO: 1, or antigen binding fragment thereof, all of amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 participate in complexing with the anti-Factor D antibody.

In a different embodiment, in the human Factor D polypeptide of SEQ ID NO: 1, or antigen binding fragment thereof, amino acid residue R172 forms hydrogen bonds with the heavy and light chains of the anti-Factor D antibody of antigen binding fragment thereof.

In a different aspect, the invention concerns a computer for producing a three- dimensional representation of: a molecular complex comprising a binding site defined by structure coordinates of amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 of human Factor D of SEQ ID NO: 1, wherein the computer comprises: (i) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises the structure coordinates of amino acid residues D131, VI 32, PI 34, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 of human Factor D of SEQ ID NO: 1, and (ii) instructions for processing the machine-readable data into said three-dimensional representation.

In one embodiment, the computer further comprises a display for displaying said structure coordinates.

In another aspect, the invention concerns a method for evaluating the potential of a chemical entity to associate with a molecular complex comprising a binding site defined by structure coordinates of amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 of human Factor D of SEQ ID NO: 1, comprising the steps of: (i) employing computational means to perform a fitting operation between the chemical entity and such binding site of the molecular complex; and (ii) analyzing the results of the fitting operation to quantify the association between the chemical entity and said binding site.

In one embodiment, the chemical entity is an antibody or an antigen binding fragment thereof, or a peptide mimetic or small molecule mimetic of the antibody or antibody fragment.

In another embodiment, the antibody, or antigen binding fragment thereof, forms hydrogen bonds with one or more of the listed residues. In yet another embodiment, the antibody, or antigen binding fragment thereof, forms hydrogen bonds with amino acid residue R172 of human Factor D of SEQ ID NO: 1.

In a further aspect, the invention concerns chemical entities, such as antibodies, antibody fragments, peptide and small molecule mimetics identifiable or identified by the claimed methods.

In a still further aspect, the invention concerns a computer for determining at least a portion of the structure coordinates corresponding to an X-ray diffraction pattern of a molecular complex, wherein said computer comprises: a) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises at least a portion of the structure coordinates according Figures 6 and 7 or Appendix 1A or IB; b) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said data comprises an X-ray diffraction pattern of said molecular complex; c) a working memory for storing instructions for processing said machine-readable data of a) and b); d) a central processing unit coupled to said working memory and to said machine-readable data of a) and b) for performing a Fourier transform of the machine readable data of (a) and for processing said machine readable data of (b) into structure coordinates; and e) a display coupled to said central processing unit for displaying said structure coordinates of said molecular complex.

Brief Description of the Drawings

Fig. 1. Crystal structure of human and cynomolgous Factor D (both in green) in complex with an anti Factor D Fab fragment (orange: heavy chain, yellow: light chain).

Fig. 2. Crystal structure of human and cynomolgous Factor D (in green) in complex with anti Factor D antibody Fab fragment (orange: heavy chain, yellow: light chain). Superposition is based on fD (the two respective molecules from each of the asymmetric units). This illustrates how similar the two cyno complexes are to each other and how similar the 2 human complexes are to each other.

Fig. 3. Superposition of all four Factor D:Fab complexes (two times cynomolgous (blue) and two times human (green). All structures are very similar with the exception of one area. A circle in the right figure marks were the cynomolgous and human Factor D structures slightly diverge.

Fig. 4. (a) Superposition of the 4 Factor D:Fab complexes (two times cynomolgous (blue) and two times human (green). The binding interface of all structures is identical. The histidine that forms part of the active site (circle in right figure) is in different conformations (human canonical, cyno inactive).

Fig. 5. Short- list of residues on Factor D (human) that interact with residues on the anti- Factor D antibody molecule. Figs. 6A and B. Residues on Factor D that interact with the light- and heavy chains of the anti Factor D Fab. Indicated in red are residues on the Fab heavy (H) and light (L) chain that form multiple hydrogen bonds with the key residue ARG-172 on human Factor D. 3 asterics ("***") indicates that the OH forms a hydrogen bond.

The figures show the distance of every atom of Factor D (labeled as chain A) that is closer than 4.5A to any atoms of the Fab (labeled as chains L and H for light and heavy chains). For example:

Asp l31A OD2 ... TYR 54H CE1 ... 3.34

... TYR 54H CZ ... 3.49

... TYR 54H OH ... 2.78 ***

means that the OD2 atom of Asp 131 in Factor D is close to 3 atoms of the Fab fragment.

These three atoms are the

CE1 atom of Tyr 54 in the heavy chain (distance 3.34)

CZ atom of Tyr 54,

and the hydroxyl group of that tyrosine, with which Asp 131 of Factor D forms a hydrogen bond.

Fig. 7A. Key residue ARG-172 on human Factor D can potentially form 6 or more hydrogen ^" 1 -bonds with heavy- and light-chain residues on the antibody.

Fig. 7B. Anti-Factor D Fab binds distant from the catalytic triad.

Fig. 8. Amino acid and nucleotide sequences of human Factor D (SEQ ID NOs: 1 and 3). Fig. 9. Amino acid and nucleotide sequences of cyno Factor D (SEQ ID NOs: 2 and 4).

Fig. 10 depicts the amino acid sequences of the variable heavy chain and the variable light chain for each humanized antibody clone #56, #111, #250, and #416 (SEQ ID NOs: 5, 6, 7 and 8, respectively). Fig. 11 shows the nucleotide sequence (SEQ ID NO: 9) of the light chain of humanized anti-Factor D Fab 238. The nucleotide sequence encodes for the light chain of humanized anti- Factor D Fab 238 with the start and stop codons shown in bold and underlined. The codon corresponding to the first amino acid in Fig. 11 (SEQ ID NO: 10) is bold and italicized. Fig. 12 shows the amino acid sequence (SEQ ID NO: 10) of the light chain for humanized anti-Factor D Fab 238. The amino acid sequence lacks the N-terminus signal sequence of the polypeptide encoded by SEQ ID NO: 9 shown in Fig. 11. The HVR sequences are bold and italicized. Variable regions are regions not underlined while first constant domain CL1 is underlined. Framework (FR) regions and HVR regions are shown. Fig. 13 shows the nucleotide sequence (SEQ ID NO: 18) of the heavy chain of humanized anti-Factor D Fab 238. The nucleotide sequence encodes for the heavy chain of humanized anti-Factor D Fab 238 with the start and stop codon shown in bold and underlined. The codon corresponding to the first amino acid in Figure 14 (SEQ ID NO: 19) is bold and italicized. Fig. 14 shows the amino acid sequence (SEQ ID NO: 19) of the heavy chain for humanized anti-Factor D Fab 238. The amino acid sequence lacks the N-terminus signal sequence of the polypeptide encoded by SEQ ID NO: 18 shown in Figure 13. The HVR sequences are bold and italicized. Variable regions are regions not underlined while first constant domain CHI is underlined. Framework (FR) regions and HVR regions are shown. Fig. 15 shows the nucleotide sequence (SEQ ID NO: 28) of the light chain of humanized anti-Factor D Fab 238-1. The nucleotide sequence encodes for the light chain of humanized anti-Factor D Fab 238-1 with the start and stop codon shown in bold and underlined. The codon corresponding to the first amino acid in FIG. 16 (SEQ ID NO: 29) is bold and italicized.

Fig. 16 shows the amino acid sequence (SEQ ID NO 29) of the light chain for humanized anti-Factor D Fab 238-1. The amino acid sequence lacks the N-terminus signal sequence of the polypeptide encoded by SEQ ID NO: 28 shown in FIG. 15. The HVR sequences are bold and italicized. Variable regions are regions not underlined while first constant domain CL1 is underlined. Framework (FR) regions and HVR regions are shown.

Fig. 17 shows the nucleotide sequence (SEQ ID NO: 30) of the heavy chain of humanized anti-Factor D Fab 238-1. The nucleotide sequence encodes for the heavy chain of humanized anti-Factor D Fab 238-1 with the start and stop codon in bold and underlined. The codon corresponding to the first amino acid in FIG. 18 (SEQ ID NO: 31) is bold and italicized.

Fig. 18 shows the amino acid sequence (SEQ ID NO: 31) of the heavy chain for humanized anti-Factor D Fab 238-1. The amino acid sequence lacks the N-terminus signal sequence of the polypeptide encoded by SEQ ID NO: 30 shown in Figure 18. The HVR sequences are bold and italicized. Variable regions are regions not underlined while first constant domain CHI is underlined. Framework (FR) regions and HVR regions are shown.

Fig. 19 shows the amino acid sequence of the light chain of anti-Factor D Fab 238-2 (SEQ ID NO: 40). Fig. 20 shows the amino acid sequence of the heavy chain of anti-Factor D Fab 238-2

(SEQ ID NO: 41).

Fig. 21. Factor B cleavage is blocked by anti-Factor D antibody but not by 8E2 (fluid-phase assay)

Figs.22, 23. Factor D (S208A) binds to C3bB pro-convertase with an affinity of 772 nM (Biacore analysis).

Figs. 24, 25 Anti-Factor D antibody blocks Factor D binding.

Figs. 26, 27 Anti-Factor D antibody does not affect catalytic cleavage.

Fig. 28. Hypothetical model depicting how anti-Factor D antibody inhibits Factor B activation.

Detailed Description of the Invention

I. Definitions

The terms "Factor D" and "complement Factor D" are used interchangeably, and refer to native sequence and variant Factor D polypeptides.

A "native sequence" Factor D, is a polypeptide having the same amino acid sequence as a Factor D polypeptide derived from nature, regardless of its mode of preparation. Thus, native sequence Factor D can be isolated from nature or can be produced by recombinant and/or synthetic means. In addition to a mature Factor D protein, such as the human Factor D protein of SEQ ID NO: 1, or the cyno Factor D protein of SEQ ID NO: 2, the term "native sequence Factor D", specifically encompasses naturally-occurring precursor forms of Factor D (e.g., an inactive preprotein, which is proteolytically cleaved to produce the active form), naturally- occurring variant forms (e.g., alternatively spliced forms) and naturally-occurring allelic variants of Factor D, as well as structural conformational variants of Factor D molecules having the same amino acid sequence as a Factor D polypeptide derived from nature. Factor D polypeptides of non-human animals, including higher primates and non-human mammals, are specifically included within this definition, including but not limited to the cyno Factor D polypeptide of SEQ ID NO: 2.

"Factor D variant" or "complement Factor D variant" means an active Factor D polypeptide as defined below having at least about 80% amino acid sequence identity to a native sequence Factor D polypeptide, such as the native sequence human Factor D polypeptide of SEQ ID NO: 1, or the native sequence cyno Factor D polypeptide of SEQ ID NO: 2. Ordinarily, a Factor D variant will have at least about 80% amino acid sequence identity, or at least about 85%o amino acid sequence identity, or at least about 90%> amino acid sequence identity, or at least about 95%> amino acid sequence identity, or at least about 98%> amino acid sequence identity, or at least about 99% amino acid sequence identity with the mature human amino acid sequence of SEQ ID NO: 1 or the mature cyno Factor D polypeptide of SEQ ID NO: 2. Preferably, the highest degree of sequence identity occurs within the active site of Factor D.

The "active site" of Factor D is defined by His-57, Asp-102, and Ser-195

(chymotrypsinogen numbering) in the human Factor D sequence. Factor D has Asp 189 (chymotrypsin numbering) at the bottom of the primary specificity pocket and cleaves an Arg peptide bond. The catalytic triad consists of His-57, Asp-102 and Ser-195. Asp-102 and His57 display atypical conformations compared with other serine proteases (Narayana et al., J. Mol. Biol. 235 (1994), 695-708). A unique sal bridge is observed between Aspl89 and Arg218 at the bottom of the SI pocket which elevated loop 214-218 and generated a deep and narrow SI pocket (Jinget al, J. Mol. Biol. 282 (1998) 1061-1081). This loop and several other residues around the active site were shown by mutational analysis to be the key structural determinants of the Factor D esterolytic activity (Kim et al, J. Biol. Chem. 270 (1995) 24399-24405). Based on these results, it was proposed that Factor D may undergo a conformational change upon binding C3b-bound factor B, resulting in the expression of proteolytic activity (Volanakis and Narayana, Protein Sci. 5 (1996) 553-564).

As used herein, "solvent accessible position" refers to a position of an amino acid residue in the variable regions of the heavy and light chains of a source antibody or antigen binding fragment that is determined, based on structure, ensemble of structures and/or modeled structure of the antibody or antigen binding fragment, as potentially available for solvent access and/or contact with a molecule, such as an antibody-specific antigen. These positions are typically found in the CDRs and on the exterior of the protein. The solvent accessible positions of an antibody or antigen binding fragment, as defined herein, can be determined using any of a number of algorithms known in the art. Preferably, solvent accessible positions are determined using coordinates from a 3 -dimensional model of an antibody, preferably using a computer program such as the Insightll program (Accelrys, San Diego, CA). Solvent accessible positions can also be determined using algorithms known in the art (e.g., Lee and Richards (1971) J. Mol. Biol. 55, 379 and Connolly (1983) J. Appl. Cryst. 16, 548). Determination of solvent accessible positions can be performed using software suitable for protein modeling and 3 -dimensional structural information obtained from an antibody. Software that can be utilized for these purposes includes SYBYL Biopolymer Module software (Tripos Associates). Generally and preferably, where an algorithm (program) requires a user input size parameter, the "size'Of a probe which is used in the calculation is set at about 1.4 Angstrom or smaller in radius. In addition, determination of solvent accessible regions and area methods using software for personal computers has been described by Pacios (1994) Comput. Chem. 18(4): 377-386.

The term "binding pocket" refers to a region of a molecule or molecular complex, which, as a result of its shape, favorably associates with another chemical entity. The term "pocket" includes, but is not limited to, a cleft, channel or site. The shape of a binding pocket may be largely pre-formed before binding of a chemical entity, may be formed simultaneously with binding of a chemical entity thereto, or may be formed by the binding of another chemical entity thereto to a different binding pocket of the molecule, which in turn induces a change in shape of the binding pocket.

The term "generating a three-dimensional structure" or "generating a three-dimensional representation" refers to converting the lists of structure coordinates into structural models or graphical representation in three-dimensional space. This can be achieved through commercially or publicly available software. A model of a three-dimensional structure of a molecule or molecular complex can thus be constructed on a computer screen by a computer that is given the structure coordinates and that comprises the correct software. The three-dimensional structure may be displayed or used to perform computer modeling or fitting operations. In addition, the structure coordinates themselves, without the displayed model, may be used to perform computer-based modeling and fitting operations. The term "crystallization solution" refers to a solution that promotes crystallization comprising at least one agent, including a buffer, one or more salts, a precipitating agent, one or more detergents, sugars or organic compounds, lanthanide ions, a poly-ionic compound and/or a stabilizer.

"Percent (%) amino acid sequence identity" is defined as the percentage of amino acid residues in a candidate sequence that are identical with the amino acid residues in a reference Factor D sequence, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity, and not considering any conservative substitutions as part of the sequence identity. Alignment for purposes of determining percent amino acid sequence identity can be achieved in various ways that are within the skill in the art, for instance, using publicly available computer software such as BLAST, BLAST-2, ALIGN or Megalign (DNASTAR) software. Those skilled in the art can determine appropriate parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full length of the sequences being compared. Sequence identity is then calculated relative to the longer sequence, i.e. even if a shorter sequence shows 100% sequence identity with a portion of a longer sequence, the overall sequence identity will be less than 100%.

"Percent (%) nucleic acid sequence identity" is defined as the percentage of nucleotides in a candidate sequence that are identical with the nucleotides in a reference Factor D-encoding sequence, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity. Alignment for purposes of determining percent nucleic acid sequence identity can be achieved in various ways that are within the skill in the art, for instance, using publicly available computer software such as BLAST, BLAST-2, ALIGN or Megalign (DNASTAR) software. Those skilled in the art can determine appropriate parameters for measuring alignment, including any algorithms needed to achieve maximal alignment over the full length of the sequences being compared. Sequence identity is then calculated relative to the longer sequence, i.e. even if a shorter sequence shows 100% sequence identity wit a portion of a longer sequence, the overall sequence identity will be less than 100%.

An "isolated" nucleic acid molecule is a nucleic acid molecule that is identified and separated from at least one contaminant nucleic acid molecule with which it is ordinarily associated in the natural source of the nucleic acid. An isolated nucleic acid molecule is other than in the form or setting in which it is found in nature. Isolated nucleic acid molecules therefore are distinguished from the nucleic acid molecule as it exists in natural cells. However, an isolated nucleic acid molecule includes nucleic acid molecules contained in cells that ordinarily express an encoded polypeptide where, for example, the nucleic acid molecule is in a chromosomal location different from that of natural cells.

An "isolated" Factor D polypeptide-encoding nucleic acid molecule is a nucleic acid molecule that is identified and separated from at least one contaminant nucleic acid molecule with which it is ordinarily associated in the natural source of the Factor D-encoding nucleic acid. An isolated Factor D polypeptide-encoding nucleic acid molecule is other than in the form or setting in which it is found in nature. Isolated Factor D polypeptide-encoding nucleic acid molecules therefore are distinguished from the encoding nucleic acid molecule(s) as they exists in natural cells. However, an isolated Factor D-encoding nucleic acid molecule includes Factor D-encoding nucleic acid molecules contained in cells that ordinarily express Factor D where, for example, the nucleic acid molecule is in a chromosomal location different from that of natural cells.

The term "antagonist" is used in the broadest sense, and includes any molecule that is capable of neutralizing, blocking, partially or fully inhibiting, abrogating, reducing or interfering with a Factor D biological activity. Factor D antagonists include, without limitation, anti-Factor D antibodies and antigen binding fragments thereof, other binding polypeptides, peptides, and non-peptide small molecules, that bind to Factor D and are capable of neutralizing, blocking, partially or fully inhibiting, abrogating, reducing or interfering with Factor D activities, such as the ability of Factor D to participate in the pathology of a complement-associated eye condition.

A "small molecule" is defined herein to have a molecular weight below about 600, preferably below about 1000 daltons.

"Active" or "activity" or "biological activity" in the context of a Factor D antagonist of the present invention is the ability the antagonize (partially or fully inhibit) a biological activity of Factor D. A preferred biological activity of a Factor D antagonist is the ability to achieve a measurable improvement in the state, e.g. pathology, of a Factor D-associated disease or condition, such as, for example, a complement-associated eye condition. The activity can be determined in in vitro or in vivo tests, including binding assays, using a relevant animal model, or human clinical trials.

The term "complement-associated eye condition" is used in the broadest sense and includes all eye conditions the pathology of which involves complement, including the classical and the alternative pathways, and in particular the alternative pathway of complement. Complement-associated eye conditions include, without limitation, macular degenerative diseases, such as all stages of age-related macular degeneration (AMD), including dry and wet (non-exudative and exudative) forms, choroidal neovascularization (CNV), uveitis, diabetic and other ischemia-related retinopathies, and other intraocular neovascular diseases, such as diabetic macular edema, pathological myopia, von Hippel-Lindau disease, histoplasmosis of the eye, Central Retinal Vein Occlusion (CRVO), corneal neovascularization, and retinal neovascularization. A preferred group of complement-associated eye conditions includes age- related macular degeneration (AMD), including non-exudative (wet) and exudative (dry or atrophic) AMD, choroidal neovascularization (CNV), diabetic retinopathy (DR), and endophthalmitis .

"Treatment" is an intervention performed with the intention of preventing the development or altering the pathology of a disorder. Accordingly, "treatment" refers to both therapeutic treatment and prophylactic or preventative measures. Those in need of treatment include those already with the disorder as well as those in which the disorder is to be prevented. In treatment of an immune related disease, a therapeutic agent may directly alter the magnitude of response of a component of the immune response, or render the disease more susceptible to treatment by other therapeutic agents, e.g., antibiotics, antifungals, anti-inflammatory agents, chemotherapeutics, etc.

The "pathology" of a disease, such as a complement-associated eye condition, includes all phenomena that compromise the well-being of the patient. This includes, without limitation, abnormal or uncontrollable cell growth (neutrophilic, eosinophilic, monocytic, lymphocytic cells), antibody production, auto-antibody production, complement production, interference with the normal functioning of neighboring cells, release of cytokines or other secretory products at abnormal levels, suppression or aggravation of any inflammatory or immunological response, infiltration of inflammatory cells (neutrophilic, eosinophilic, monocytic, lymphocytic) into cellular spaces, etc.

The term "mammal" as used herein refers to any animal classified as a mammal, including, without limitation, humans, higher primates, domestic and farm animals, and zoo, sports or pet animals such horses, pigs, cattle, dogs, cats and ferrets, etc. In a preferred embodiment of the invention, the mammal is a human.

Administration "in combination with" one or more further therapeutic agents includes simultaneous (concurrent) and consecutive administration in any order.

"Therapeutically effective amount" is the amount of a "Factor D antagonist" which is required to achieve a measurable improvement in the state, e.g. pathology, of the target disease or condition, such as, for example, a complement-associated eye condition.

The term "control sequences" refers to DNA sequences necessary for the expression of an operably linked coding sequence in a particular host organism. The control sequences that are suitable for prokaryotes, for example, include a promoter, optionally an operator sequence, and a ribosome binding site. Eukaryotic cells are known to utilize promoters, polyadenylation signals, and enhancers.

Nucleic acid is "operably linked" when it is placed into a functional relationship with another nucleic acid sequence. For example, DNA for a presequence or secretory leader is operably linked to DNA for a polypeptide if it is expressed as a preprotein that participates in the secretion of the polypeptide; a promoter or enhancer is operably linked to a coding sequence if it affects the transcription of the sequence; or a ribosome binding site is operably linked to a coding sequence if it is positioned so as to facilitate translation. Generally, "operably linked" means that the DNA sequences being linked are contiguous, and, in the case of a secretory leader, contiguous and in reading phase. However, enhancers do not have to be contiguous. Linking is accomplished by ligation at convenient restriction sites. If such sites do not exist, the synthetic oligonucleotide adaptors or linkers are used in accordance with conventional practice.

"Stringency" of hybridization reactions is readily determinable by one of ordinary skill in the art, and generally is an empirical calculation dependent upon probe length, washing temperature, and salt concentration. In general, longer probes require higher temperatures for proper annealing, while shorter probes need lower temperatures. Hybridization generally depends on the ability of denatured DNA to reanneal when complementary strands are present in an environment below their melting temperature. The higher the degree of desired homology between the probe and hybridizable sequence, the higher the relative temperature that can be used. As a result, it follows that higher relative temperatures would tend to make the reaction conditions more stringent, while lower temperatures less so. For additional details and explanation of stringency of hybridization reactions, see Ausubel et ah, Current Protocols in Molecular Biology, Wiley Interscience Publishers, (1995).

"Stringent conditions" or "high stringency conditions", as defined herein, may be identified by those that: (1) employ low ionic strength and high temperature for washing, for example 0.015 M sodium chloride/0.0015 M sodium citrate/0.1% sodium dodecyl sulfate at 50°C; (2) employ during hybridization a denaturing agent, such as formamide, for example, 50%> (v/v) formamide with 0.1% bovine serum albumin/0.1% Ficoll/0.1% polyvinylpyrrolidone/5 OmM sodium phosphate buffer at pH 6.5 with 750 mM sodium chloride, 75 mM sodium citrate at 42C; or (3) employ 50% formamide, 5 x SSC (0.75 M NaCl, 0.075 M sodium citrate), 50 mM sodium phosphate (pH 6.8), 0.1 % sodium pyrophosphate, 5 x Denhardt's solution, sonicated salmon sperm DNA (50 μg/ml), 0.1%> SDS, and 10%> dextran sulfate at 42°C, with washes at 42°C in 0.2 x SSC (sodium chloride/sodium citrate) and 50%> formamide at 55 °C, followed by a high-stringency wash consisting of 0.1 x SSC containing EDTA at 55°C.

"Moderately stringent conditions" may be identified as described by Sambrook et ah, Molecular Cloning: A Laboratory Manual, New York: Cold Spring Harbor Press, 1989, and include the use of washing solution and hybridization conditions {e.g., temperature, ionic strength and %SDS) less stringent that those described above. An example of moderately stringent conditions is overnight incubation at 37 °C in a solution comprising: 20% formamide, 5 x SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH 7.6), 5 x Denhardt's solution, 10% dextran sulfate, and 20 mg/mL denatured sheared salmon sperm DNA, followed by washing the filters in 1 x SSC at about 37-50 °C. The skilled artisan will recognize how to adjust the temperature, ionic strength, etc. as necessary to accommodate factors such as probe length and the like.

The term "epitope tagged" when used herein refers to a chimeric polypeptide comprising a polypeptide of the invention fused to a "tag polypeptide". The tag polypeptide has enough residues to provide an epitope against which an antibody can be made, yet is short enough such that it does not interfere with activity of the polypeptide to which it is fused. The tag polypeptide preferably also is fairly unique so that the antibody does not substantially cross-react with other epitopes. Suitable tag polypeptides generally have at least six amino acid residues and usually between about 8 and 50 amino acid residues (preferably, between about 10 and 20 amino acid residues).

The term "antibody" is used in the broadest sense and specifically covers, without limitation, single anti-Factor D monoclonal antibodies (including agonist, antagonist, and neutralizing antibodies) and anti-Factor D antibody compositions with polyepitopic specificity. The term "monoclonal antibody" as used herein refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally-occurring mutations that may be present in minor amounts.

The term "monoclonal antibody" as used herein refers to an antibody obtained from a population of substantially homogeneous antibodies, i.e., the individual antibodies comprising the population are identical except for possible naturally occurring mutations that may be present in minor amounts. Monoclonal antibodies are highly specific, being directed against a single antigenic site. Furthermore, in contrast to conventional (polyclonal) antibody preparations which typically include different antibodies directed against different determinants (epitopes), each monoclonal antibody is directed against a single determinant on the antigen. The modifier "monoclonal" indicates the character of the antibody as being obtained from a substantially homogeneous population of antibodies, and is not to be construed as requiring production of the antibody by any particular method. For example, the monoclonal antibodies to be used in accordance with the present invention may be made by the hybridoma method first described by Kohler et al. (1975) Nature 256:495, or may be made by recombinant DNA methods (see, e.g., U.S. Patent No. 4,816,567). The "monoclonal antibodies" may also be isolated from phage antibody libraries using the techniques described in Clackson et al. (1991) Nature 352:624-628 and Marks et al. (1991) J. Mol. Biol. 222:581-597, for example.

The monoclonal antibodies herein specifically include "chimeric" antibodies (immunoglobulins) in which a portion of the heavy and/or light chain is identical with or homologous to corresponding sequences in antibodies derived from a particular species or belonging to a particular antibody class or subclass, while the remainder of the chain(s) is identical with or homologous to corresponding sequences in antibodies derived from another species or belonging to another antibody class or subclass, as well as fragments of such antibodies, so long as they exhibit the desired biological activity (U.S. Patent No. 4,816,567; and Morrison et al. (1984) Proc. Natl. Acad. Sci. USA 81 :6851-6855).

"Humanized" forms of non-human {e.g., murine) antibodies are chimeric antibodies which contain minimal sequence derived from non-human immunoglobulin. For the most part, humanized antibodies are human immunoglobulins (recipient antibody) in which residues from a hypervariable region of the recipient are replaced by residues from a hypervariable region of a non-human species (donor antibody) such as mouse, rat, rabbit or nonhuman primate having the desired specificity, affinity, and capacity. In some instances, Fv framework region (FR) residues of the human immunoglobulin are replaced by corresponding non-human residues. Furthermore, humanized antibodies may comprise residues which are not found in the recipient antibody or in the donor antibody. These modifications are made to further refine antibody performance. In general, the humanized antibody will comprise substantially all of at least one, and typically two, variable domains, in which all or substantially all of the hypervariable loops correspond to those of a non-human immunoglobulin and all or substantially all of the FR regions are those of a human immunoglobulin sequence. The humanized antibody optionally also will comprise at least a portion of an immunoglobulin constant region (Fc), typically that of a human immunoglobulin. For further details, see Jones et al. (1986) Nature 321 :522-525; Riechmann et al. (1988) Nature 332:323-329; and Presta (1992) Curr. Op. Struct. Biol. 2:593-596.

A "species-dependent antibody" is one which has a stronger binding affinity for an antigen from a first mammalian species than it has for a homologue of that antigen from a second mammalian species. Normally, the species-dependent antibody "binds specifically" to a human antigen (i.e. has a binding affinity (Ka) value of no more than about 1 x 10 ^"7 M,

-8 -9 preferably no more than about 1 x 10 ^" M and most preferably no more than about 1 x 10 ^" M) but has a binding affinity for a homologue of the antigen from a second nonhuman mammalian species which is at least about 50 fold, or at least about 500 fold, or at least about 1000 fold, weaker than its binding affinity for the human antigen. The species-dependent antibody can be any of the various types of antibodies as defined above, but preferably is a humanized or human antibody.

As used herein, "antibody mutant" or "antibody variant" refers to an amino acid sequence variant of the species-dependent antibody wherein one or more of the amino acid residues of the species-dependent antibody have been modified. Such mutants necessarily have less than 100% sequence identity or similarity with the species-dependent antibody. In a preferred embodiment, the antibody mutant will have an amino acid sequence having at least 75% amino acid sequence identity or similarity with the amino acid sequence of either the heavy or light chain variable domain of the species-dependent antibody, more preferably at least 80%, more preferably at least 85%, more preferably at least 90%, and most preferably at least 95%. Identity or similarity with respect to this sequence is defined herein as the percentage of amino acid residues in the candidate sequence that are identical (i.e same residue) or similar (i.e. amino acid residue from the same group based on common side-chain properties, see below) with the species-dependent antibody residues, after aligning the sequences and introducing gaps, if necessary, to achieve the maximum percent sequence identity. None of N-terminal, C-terminal, or internal extensions, deletions, or insertions into the antibody sequence outside of the variable domain shall be construed as affecting sequence identity or similarity.

An "isolated" antibody is one which has been identified and separated and/or recovered from a component of its natural environment. Contaminant components of its natural environment are materials which would interfere with diagnostic or therapeutic uses for the antibody, and may include enzymes, hormones, and other proteinaceous or nonproteinaceous solutes. In preferred embodiments, the antibody will be purified (1) to greater than 95% by weight of antibody as determined by the Lowry method, and most preferably more than 99% by weight, (2) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (3) to homogeneity by SDS-PAGE under reducing or nonreducing conditions using Coomassie blue or, preferably, silver stain. Isolated antibody includes the antibody in situ within recombinant cells since at least one component of the antibody's natural environment will not be present. Ordinarily, however, isolated antibody will be prepared by at least one purification step.

As used herein, "antibody variable domain" refers to the portions of the light and heavy chains of antibody molecules that include amino acid sequences of Complementarity Determining Regions (CDRs; ie., CDR1, CDR2, and CDR3), and Framework Regions (FRs). V _H refers to the variable domain of the heavy chain. V _L refers to the variable domain of the light chain. According to the methods used in this invention, the amino acid positions assigned to CDRs and FRs may be defined according to Kabat (Sequences of Proteins of Immunological Interest (National Institutes of Health, Bethesda, Md., 1987 and 1991)). Amino acid numbering of antibodies or antigen binding fragments is also according to that of Kabat.

As used herein, the term "Complementarity Determining Regions (CDRs; ie., CDR1, CDR2, and CDR3) refers to the amino acid residues of an antibody variable domain the presence of which are necessary for antigen binding. Each variable domain typically has three CDR regions identified as CDR1, CDR2 and CDR3. Each complementarity determining region may comprise amino acid residues from a "complementarity determining region" as defined by Kabat (i.e. about residues 24-34 (LI), 50-56 (L2) and 89-97 (L3) in the light chain variable domain and 31-35 (HI), 50-65 (H2) and 95-102 (H3) in the heavy chain variable domain; Kabat et al., Sequences of Proteins of Immunological Interest, 5 ^th Ed. Public Health Service, National Institutes of Health, Bethesda, MD. (1991)) and/or those residues from a "hypervariable loop" (i.e. about residues 26-32 (LI), 50-52 (L2) and 91-96 (L3) in the light chain variable domain and 26-32 (HI), 53-55 (H2) and 96-101 (H3) in the heavy chain variable domain; Chothia and Lesk (1987) J. Mol. Biol. 196:901-917). In some instances, a complementarity determining region can include amino acids from both a CDR region defined according to Kabat and a hypervariable loop. For example, the CDRH1 of the heavy chain of antibody 4D5 includes amino acids 26 to 35.

"Framework regions" (hereinafter FR) are those variable domain residues other than the CDR residues. Each variable domain typically has four FRs identified as FR1, FR2, FR3 and FR4. If the CDRs are defined according to Kabat, the light chain FR residues are positioned at about residues 1-23 (LCFR1), 35-49 (LCFR2), 57-88 (LCFR3), and 98-107 (LCFR4) and the heavy chain FR residues are positioned about at residues 1-30 (HCFR1), 36-49 (HCFR2), 66-94 (HCFR3), and 103-113 (HCFR4) in the heavy chain residues. If the CDRs comprise amino acid residues from hypervariable loops, the light chain FR residues are positioned about at residues 1- 25 (LCFR1), 33-49 (LCFR2), 53-90 (LCFR3), and 97-107 (LCFR4) in the light chain and the heavy chain FR residues are positioned about at residues 1-25 (HCFR1), 33-52 (HCFR2), 56-95 (HCFR3), and 102-113 (HCFR4) in the heavy chain residues. In some instances, when the CDR comprises amino acids from both a CDR as defined by Kabat and those of a hypervariable loop, the FR residues will be adjusted accordingly. For example, when CDRH1 includes amino acids H26-H35, the heavy chain FRl residues are at positions 1-25 and the FR2 residues are at positions 36-49.

As used herein, "codon set" refers to a set of different nucleotide triplet sequences used to encode desired variant amino acids. A set of oligonucleotides can be synthesized, for example, by solid phase synthesis, including sequences that represent all possible combinations of nucleotide triplets provided by the codon set and that will encode the desired group of amino acids. A standard form of codon designation is that of the IUB code, which is known in the art and described herein. A codon set typically is represented by 3 capital letters in italics, eg. NNK, NNS, XYZ, DVK and the like. A "non-random codon set", as used herein, thus refers to a codon set that encodes select amino acids that fulfill partially, preferably completely, the criteria for amino acid selection as described herein. Synthesis of oligonucleotides with selected nucleotide "degeneracy" at certain positions is well known in that art, for example the TRIM approach (Knappek et al. (1999) J. Mol. Biol. 296:57-86); Garrard & Henner (1993) Gene 128: 103). Such sets of oligonucleotides having certain codon sets can be synthesized using commercial nucleic acid synthesizers (available from, for example, Applied Biosystems, Foster City, CA), or can be obtained commercially (for example, from Life Technologies, Rockville, MD). Therefore, a set of oligonucleotides synthesized having a particular codon set will typically include a plurality of oligonucleotides with different sequences, the differences established by the codon set within the overall sequence. Oligonucleotides, as used according to the invention, have sequences that allow for hybridization to a variable domain nucleic acid template and also can, but does not necessarily, include restriction enzyme sites useful for, for example, cloning purposes.

The term "antibody fragment" is used herein in the broadest sense and includes, without limitation, Fab, Fab', F(ab') ₂ , scFv, (scFv) ₂ , dAb, and complementarity determining region (CDR) fragments, linear antibodies, single-chain antibody molecules, minibodies, diabodies, and multispecific antibodies formed from antibody fragments.

An "Fv" fragment is an antibody fragment which contains a complete antigen recognition and binding site. This region consists of a immer of one heavy and one light chain variable domain in tight association, which can be covalent in nature, for example in scFv. It is in this configuration that the three CDRs of each variable domain interact to define an antigen binding site on the surface of the V _R -V _L immer. Collectively, the six CDRs or a subset thereof confer antigen binding specificity to the antibody. However, even a single variable domain (or half of an Fv comprising only three CDRs specific for an antigen) has the ability to recognize and bind antigen, although usually at a lower affinity than the entire binding site.

The "Fab" fragment contains a variable and constant domain of the light chain and a variable domain and the first constant domain (CHI) of the heavy chain. F(ab') ₂ antibody fragments comprise a pair of Fab fragments which are generally covalently linked near their carboxy termini by hinge cysteines between them. Other chemical couplings of antibody fragments are also known in the art.

"Single-chain Fv" or "scFv" antibody fragments comprise the V _H and V _L domains of antibody, wherein these domains are present in a single polypeptide chain. Generally the Fv polypeptide further comprises a polypeptide linker between the V _H and V _L domains, which enables the scFv to form the desired structure for antigen binding. For a review of scFv, see Pluckthun in The Pharmacology of Monoclonal Antibodies, Vol 113, Rosenburg and Moore eds. Springer-Verlag, New York, pp. 269-315 (1994).

The term "diabodies" refers to small antibody fragments with two antigen binding sites, which fragments comprise a heavy chain variable domain (V _H ) connected to a light chain variable domain (V _L ) in the same polypeptide chain (V _H and V _L ). By using a linker that is too short to allow pairing between the two domains on the same chain, the domains are forced to pair with the complementary domains of another chain and create two antigen binding sites. Diabodies are described more fully in, for example, EP 404,097; WO 93/11161; and Hollinger et al. (1993) Proc. Natl. Acad. Sci. USA 90:6444-6448.

The expression "linear antibodies" refers to the antibodies described in Zapata et al. (1995 Protein Eng, 8(10): 1057-1062). Briefly, these antibodies comprise a pair of tandem Fd segments (V _H -C _H 1-V _H -C _H 1) which, together with complementary light chain polypeptides, form a pair of antigen binding regions. Linear antibodies can be bispecific or monospecific.

As used herein, "library" refers to a plurality of antibody or antibody fragment sequences

(for example, polypeptides of the invention), or the nucleic acids that encode these sequences, the sequences being different in the combination of variant amino acids that are introduced into these sequences according to the methods of the invention.

"Phage display" is a technique by which variant polypeptides are displayed as fusion proteins to at least a portion of coat protein on the surface of phage, e.g., filamentous phage, particles. A utility of phage display lies in the fact that large libraries of randomized protein variants can be rapidly and efficiently sorted for those sequences that bind to a target antigen with high affinity. Display of peptide and protein libraries on phage has been used for screening millions of polypeptides for ones with specific binding properties. Polyvalent phage display methods have been used for displaying small random peptides and small proteins through fusions to either gene III or gene VIII of filamentous phage. Wells and Lowman (1992) Curr. Opin. Struct. Biol. 3:355-362, and references cited therein. In a monovalent phage display, a protein or peptide library is fused to a gene III or a portion thereof, and expressed at low levels in the presence of wild type gene III protein so that phage particles display one copy or none of the fusion proteins. Avidity effects are reduced relative to polyvalent phage so that sorting is on the basis of intrinsic ligand affinity, and phagemid vectors are used, which simplify DNA manipulations. Lowman and Wells (1991) Methods: A companion to Methods in Enzymology 3:205-0216.

A "phagemid" is a plasmid vector having a bacterial origin of replication, e.g., ColEl , and a copy of an intergenic region of a bacteriophage. The phagemid may be used on any known bacteriophage, including filamentous bacteriophage and lambdoid bacteriophage. The plasmid will also generally contain a selectable marker for antibiotic resistance. Segments of DNA cloned into these vectors can be propagated as plasmids. When cells harboring these vectors are provided with all genes necessary for the production of phage particles, the mode of replication of the plasmid changes to rolling circle replication to generate copies of one strand of the plasmid DNA and package phage particles. The phagemid may form infectious or noninfectious phage particles. This term includes phagemids which contain a phage coat protein gene or fragment thereof linked to a heterologous polypeptide gene as a gene fusion such that the heterologous polypeptide is displayed on the surface of the phage particle.

The term "phage vector" means a double stranded replicative form of a bacteriophage containing a heterologous gene and capable of replication. The phage vector has a phage origin of replication allowing phage replication and phage particle formation. The phage is preferably a filamentous bacteriophage, such as an Ml 3, fl, fd, Pf3 phage or a derivative thereof, or a lambdoid phage, such as λ, 21, phi80, phi81, 82, 424, 434, etc., or a derivative thereof.

The terms "peptide mimetic" and "peptidomimetic" are used interchangeably, and refer to conformationally well defined peptide molecules, that mimic the structures and binding properties of a Factor D recognition region (epitope) of an anti-Factor D antibody herein. The crystal structures herein enable the identification and preparation of such peptide mimetics. Detailed Description

Crystal Structure and Molecular Modeling

Applicants have solved the three-dimensional structure of a Factor D/anti-F actor D antibody complex using high resolution X-ray crystallography. This work has provided, for the first time, information about the binding site of Factor D for an anti-Factor D antibody, and of the residues of an anti-Factor D antibody heavy and light chains participating in binding to Factor D.

In one aspect, the invention concerns crystallizable compositions comprising a Factor D polypeptide complexed with an anti-Factor D antibody or an antigen binding fragment of such antibody.

The crystallizable compositions provided by the present invention are amenable to X-ray crystallography. Therefore, this invention also encompasses crystals of the crystallizable compositions.

This invention further provides the three dimensional structure of a Factor D/anti-Factor D antibody complex at high resolution (e.g. 2.1 A or 2.4 A resolution, see Figure 1)

X-ray crystallo graphic techniques are known in the art. The three-dimensional structure of the Factor D/anti-Factor D antibody complex is defined by a set of structure coordinates as set forth in Appendices 1A and IB. The term "structure coordinates" refers to Cartesian atomic coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of X-rays by the atoms of an extracellular domain of a Factor D/anti- Factor D antibody complex in crystalline form.

As shown in Figures 5, 6A and 6B, it has been determined that amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 of human Factor D of SEQ ID NO: 1 participate in binding to an anti- factor B antibody Fab fragment. It has further been found that, for binding purposes, the key residue in the human Factor D amino acid sequence is R172, which can potentially form six or more hydrogen bonds with the anti-Factor D antibody heavy and light chains. Figures 6A and 6B also show the residues in the anti-Factor D antibody heavy and light chains which are in close proximity to and available to interact (for example by forming hydrogen bonds) with the human Factor D molecule.

Those of ordinary skill in the pertinent art will understand that a set of structure coordinates for a polypeptide complex is a relative set of points that define a shape in three dimensions. Therefore, it is possible that a different set of coordinates defines a similar or identical shape. Moreover, slight variations in the individual coordinates will have little effect on the overall shape.

In accordance with the present invention, the structure coordinates of a complex comprising Factor D and an anti-Factor D antibody or an antigen binding fragment thereof, for example a Fab fragment of an anti-Factor D monoclonal antibody, may be stored in a machine- readable storage medium, where the machine can be a computer. The data generated can be used for a variety of purposes, such as, for example, drug discovery, discovery of anti-Factor D antibody variants with improved properties, such as improved specific binding to Factor D, and X-ray crystallographic analysis of other protein crystals. In order to use the structure coordinates generated for the Factor D/anti-factor antibody complex, it is necessary to convert the structural coordinates into a three-dimensional shape. This can be readily accomplished through the use of commercially available software that is capable of generating a three-dimensional graphical representation of molecular complexes, or portions thereof, from a set of structure coordinates. Such three-dimensional representation is also within the scope of the present invention.

Thus, the invention includes a computer for producing a three-dimensional representation of: a molecular complex comprising a binding site defined by structure coordinates of amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G 177, 1179, E181, R222, and K223 of human Factor D of SEQ ID NO: 1, wherein the computer comprises: (i) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein such data comprises the structure coordinates of amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 of human Factor D of SEQ ID NO: 1, and (ii) instructions for processing the machine -readable data into said three-dimensional representation.

In certain embodiments, the computer comprises a display for displaying the structure coordinates.

In another aspect, the invention concerns a method for evaluating the potential of a chemical entity to associate with a molecular complex comprising a binding site defined by structure coordinates of amino acid residues D131, V132, P134, D165, R166, A167, T168, N170, R171, R172, T173, D176, G177, 1179, E181, R222, and K223 of human Factor D of SEQ ID NO: 1, comprising the steps of: (i) employing computational means to perform a fitting operation between the chemical entity and said binding site of the molecular complex; and (ii) analyzing the results of the fitting operation to quantify the association between the chemical entity and said binding site. The chemical entity may, for example, be an agonist or antagonist of Factor D, including agonist and antagonist antibodies and variants of the anti-Factor D antibody used for determination of the crystal structure and three-dimensional confirmation of Factor D complexed with an anti-Factor D antibody herein, or an antigen binding fragment of such antibodies. The chemical entity may also be a peptide mimetic of an agonist or antagonist Factor D antibody or antibody fragment. The potential agonist or antagonist may be synthesized, and contacted with Factor D to determine its ability to interact with (e.g. bind to) Factor D. It is further possible to determine whether a potential antagonist interrupts the Factor D/anti-F actor D antibody interaction. Before actually testing the binding of the potential antagonist to Factor D, it is possible, using the molecular coordinates and three-dimensional models provided by the present invention, to analyze the structure of such compound by computer modeling techniques. If computer modeling indicates a strong interaction or binding, the compound may then be produced (e.g. by synthetic and/or recombinant means) and tested for its ability to bind to Factor D. Anti-Factor D antibodies

Anti-Factor D antibodies are selected using a Factor D antigen derived from a mammalian species. Preferably the antigen is human Factor D. However, Factor Ds from other species such as cyno or murine Factor D can also be used as the target antigen. The Factor D antigens from various mammalian species may be isolated from natural sources. In other embodiments, the antigen is produced recombinantly or made using other synthetic methods known in the art.

The antibody selected following the methods of the present invention will normally have a sufficiently strong binding affinity for the Factor D antigen. For example, the antibody may bind human Factor D with a K _d value of no more than about 5 nM, preferably no more than about 2 nM, and more preferably no more than about 500pM. Antibody affinities may be determined by a surface plasmon resonance based assay (such as the BIAcore assay as described in Examples); enzyme-linked immunoabsorbent assay (ELISA); and competition assays {e.g. RIA's), for example.

Also, the antibody may be subject to other biological activity assays, e.g., in order to evaluate its effectiveness as a therapeutic. Such assays are known in the art and depend on the target antigen and intended use for the antibody. Examples include the HUVEC inhibition assay; tumor cell growth inhibition assays (as described in WO 89/06692, for example); antibody-dependent cellular cytotoxicity (ADCC) and complement-mediated cytotoxicity (CDC) assays (US Patent 5,500,362); and in vitro and in vivo assays described below for identifying Factor D antagonists.

To screen for antibodies which bind to a particular epitope on the antigen of interest, a routine cross-blocking assay such as that described in Antibodies, A Laboratory Manual, Cold Spring Harbor Laboratory, Ed Harlow and David Lane (1988), can be performed. Alternatively, epitope mapping, e.g. as described in Champe et al. (1995) J. Biol. Chem. 270: 1388-1394, can be performed to determine whether the antibody binds an epitope of interest.

In a preferred embodiment, the anti-Factor D antibodies are selected using a unique phage display approach. The approach involves generation of synthetic antibody phage libraries based on single framework template, design of sufficient diversities within variable domains, display of polypeptides having the diversified variable domains, selection of candidate antibodies with high affinity to target Factor D antigen, and isolation of the selected antibodies.

Details of the phage display methods can be found, for example, in WO90/05144; WO90/14424; WO90/14430, WO92/01047, W093/11236; WO91/05058; WO03/102157; WO91/05058; US 6,291,158; US 6,291,159, US 6,291,160, US 6,291,161; US 5,969,108, US 5,885,793; and US 5,643,768.

Factor D antibodies are disclosed in US Patent Publication Nos. 20020081293,

20080118506, 20090181017, and 20090269338, the entire disclosures of which are hereby expressly incorporated by reference. Preferred antibodies include antibody clones #56, #111, #250, and #416, the variable heavy chain and the variable light chain amino acid sequences of which are shown in Figure 10 (SEQ ID NOs: 5, 6, 7 and 8, respectively).

Further preferred anti-Factor D antibody is anti-Factor D Fab 238. The nucleotide sequence (SEQ ID NO: 9) of the light chain of humanized anti-Factor D Fab 238 is shown in Fig. 11 (SEQ ID NO: 9). The nucleotide sequence encodes for the light chain of humanized anti-Factor D Fab 238 with the start and stop codons shown in bold and underlined. The codon corresponding to the first amino acid in Fig. 11 (SEQ ID NO: 10) is bold and italicized. Fig. 12 shows the amino acid sequence (SEQ ID NO: 10) of the light chain for humanized anti-Factor D Fab 238. The amino acid sequence lacks the N-terminus signal sequence of the polypeptide encoded by SEQ ID NO: 9 shown in Fig. 11. The HVR sequences are bold and italicized.

Variable regions are regions not underlined while first constant domain CL1 is underlined.

Framework (FR) regions and HVR regions are shown. Figure 13 shows the nucleotide sequence (SEQ ID NO: 18) of the heavy chain of humanized anti-Factor D Fab 238. The nucleotide sequence encodes for the heavy chain of humanized anti-Factor D Fab 238 with the start and stop codon shown in bold and underlined. The codon corresponding to the first amino acid in Figure 14 (SEQ ID NO: 19) is bold and italicized. Figure 14 shows the amino acid sequence (SEQ ID NO: 19) of the heavy chain for humanized anti-Factor D Fab 238. The amino acid sequence lacks the N-terminus signal sequence of the polypeptide encoded by SEQ ID NO: 18 shown in Figure 13. The HVR sequences are bold and italicized. Variable regions are regions not underlined while first constant domain CHI is underlined. Framework (FR) regions and FFVR regions are shown.

A still further preferred anti-Factor D antibody is anti-Factor D Fab 238-1. Figure 15 shows the nucleotide sequence (SEQ ID NO: 28) of the light chain of humanized anti-Factor D Fab 238-1. The nucleotide sequence encodes for the light chain of humanized anti-Factor D Fab 238-1 with the start and stop codon shown in bold and underlined. The codon corresponding to the first amino acid in FIG. 16 (SEQ ID NO: 29) is bold and italicized. Figure 16 shows the amino acid sequence (SEQ ID NO 29) of the light chain for humanized anti -Factor D Fab 238-1. The amino acid sequence lacks the N-terminus signal sequence of the polypeptide encoded by SEQ ID NO: 28 shown in FIG. 15. The HVR sequences are bold and italicized. Variable regions are regions not underlined while first constant domain CL1 is underlined. Framework (FR) regions and HVR regions are shown. Figure 17 shows the nucleotide sequence (SEQ ID NO: 30) of the heavy chain of humanized anti-Factor D Fab 238-1. The nucleotide sequence encodes for the heavy chain of humanized anti-Factor D Fab 238-1 with the start and stop codon in bold and underlined. The codon corresponding to the first amino acid in FIG. 18 (SEQ ID NO: 31) is bold and italicized. Figure 18 shows the amino acid sequence (SEQ ID NO: 31) of the heavy chain for humanized anti-Factor D Fab 238-1. The amino acid sequence lacks the N- terminus signal sequence of the polypeptide encoded by SEQ ID NO: 30 shown in Figure 18. The HVR sequences are bold and italicized. Variable regions are regions not underlined while first constant domain CHI is underlined. Framework (FR) regions and HVR regions are shown.

Another preferred anti-Factor D antibody is anti-factor D Fab 238-2, having the light chain amino acid sequence shown in FIG. 19 (SEQ ID NO: 40) and the heavy chain amino acid sequence shown in FIG. 20 (SEQ ID NO: 41).

Preferred mimetics, e.g. peptidomimetics, mimic the binding and/or biological properties of the preferred antibodies or antibody fragments herein.

Uses of Factor D antibodies and other Factor D antagonists

The invention herein provides Factor D antagonists, including anti-Factor D antibodies, and variants thereof, and fragments thereof (e.g. antigen-binding fragments) useful for the prevention and treatment of complement-associated conditions, including eye conditions (all eye conditions and diseases the pathology of which involves complement, including the classical and the alternative pathways, and in particular the alternative pathway of complement), such as, for example, macular degenerative diseases, such as all stages of age-related macular degeneration (AMD), including dry and wet (non-exudative and exudative) forms, choroidal neovascularization (CNV), uveitis, diabetic and other ischemia-related retinopathies, endophthalmitis, and other intraocular neovascular diseases, such as diabetic macular edema, pathological myopia, von Hippel-Lindau disease, histoplasmosis of the eye, Central Retinal Vein Occlusion (CRVO), corneal neovascularization, and retinal neovascularization. One group of complement-associated eye conditions includes age-related macular degeneration (AMD), including non-exudative (e.g. intermediate dry AMD or geographic atrophy (GA)) and exudative (e.g. wet AMD (choroidal neovascularization (CNV)) AMD, diabetic retinopathy (DR), endophthalmitis and uveitis. In one example, complement-associated eye condition is intermediate dry AMD. In one example, complement-associated eye condition is geographic atrophy. In one example, complement-associated eye condition is wet AMD (choroidal neovascularization (CNV)).

AMD is age-related degeneration of the macula, which is the leading cause of irreversible visual dysfunction in individuals over the age of 60. Two types of AMD exist, non- exudative (dry) and exudative (wet) AMD. The dry, or nonexudative, form involves atrophic and hypertrophic changes in the retinal pigment epithelium (RPE) underlying the central retina (macula) as well as deposits (drusen) on the RPE. Patients with nonexudative AMD can progress to the wet, or exudative, form of AMD, in which abnormal blood vessels called choroidal neovascular membranes (CNVMs) develop under the retina, leak fluid and blood, and ultimately cause a blinding disciform scar in and under the retina. Nonexudative AMD, which is usually a precursor of exudative AMD, is more common. The presentation of nonexudative AMD varies: hard drusen, soft drusen, RPE geographic atrophy, and pigment clumping can be present. Complement components are deposited on the RPE early in AMD and are major constituents of drusen.

Factor D antagonists can be evaluated in a variety of cell-based assays and animal models of complement-associated diseases or disorders.

Thus, for example, recombinant (transgenic) animal models can be engineered by introducing the coding portion of the genes of interest into the genome of animals of interest, using standard techniques for producing transgenic animals. Animals that can serve as a target for transgenic manipulation include, without limitation, mice, rats, rabbits, guinea pigs, sheep, goats, pigs, and non-human primates, e.g. baboons, chimpanzees and other monkeys.

Techniques known in the art to introduce a transgene into such animals include pronucleic microinjection (Hoppe and Wanger, U.S. Patent No. 4,873,191); retrovirus-mediated gene transfer into germ lines (e.g., Van der Putten et al, Proc. Natl. Acad. Sci. USA 82, 6148-615 [1985]); gene targeting in embryonic stem cells (Thompson et al., Cell 56, 313-321 [1989]); electroporation of embryos (Lo, Mol. Cell. Biol. 3, 1803-1814 [1983]); sperm-mediated gene transfer (Lavitrano et al, Cell 57, 71 '-73 [1989]). For review, see, for example, U.S. Patent No. 4,736,866.

For the purpose of the present invention, transgenic animals include those that carry the transgene only in part of their cells ("mosaic animals"). The transgene can be integrated either as a single transgene, or in concatamers, e.g., head-to-head or head-to-tail tandems. Selective introduction of a transgene into a particular cell type is also possible by following, for example, the technique of Lasko et al, Proc. Natl. Acad. Sci. USA 89, 623-636 (1992).

The expression of the transgene in transgenic animals can be monitored by standard techniques. For example, Southern blot analysis or PCR amplification can be used to verify the integration of the transgene. The level of mRNA expression can then be analyzed using techniques such as in situ hybridization, Northern blot analysis, PCR, or immunocytochemistry.

The animals may be further examined for signs of immune disease pathology, for example by histological examination to determine infiltration of immune cells into specific tissues. Blocking experiments can also be performed in which the transgenic animals are treated with a candidate Factor D antagonist to determine the extent of effects on complement and complement activation, including the classical and alternative pathways, or T cell proliferation. In these experiments, blocking antibodies which bind to the polypeptide of the invention, are administered to the animal and the biological effect of interest is monitored.

Alternatively, "knock out" animals can be constructed which have a defective or altered gene encoding Factor D, as a result of homologous recombination between the endogenous gene encoding the Factor D polypeptide and altered genomic DNA encoding the same polypeptide introduced into an embryonic cell of the animal. For example, cDNA encoding Factor D can be used to clone genomic DNA encoding Factor D in accordance with established techniques. A portion of the genomic DNA encoding Factor D can be deleted or replaced with another gene, such as a gene encoding a selectable marker which can be used to monitor integration.

Typically, several kilobases of unaltered flanking DNA (both at the 5' and 3' ends) are included in the vector [see e.g., Thomas and Capecchi, Cell, 51 :503 (1987) for a description of homologous recombination vectors]. The vector is introduced into an embryonic stem cell line (e.g., by electroporation) and cells in which the introduced DNA has homologously recombined with the endogenous DNA are selected [see e.g., Li et al, Cell, 69:915 (1992)]. The selected cells are then injected into a blastocyst of an animal (e.g., a mouse or rat) to form aggregation chimeras [see e.g., Bradley, in Teratocarcinomas and Embryonic Stem Cells: A Practical Approach, E. J. Robertson, ed. (IRL, Oxford, 1987), pp. 113-152]. A chimeric embryo can then be implanted into a suitable pseudopregnant female foster animal and the embryo brought to term to create a "knock out" animal. Progeny harboring the homologously recombined DNA in their germ cells can be identified by standard techniques and used to breed animals in which all cells of the animal contain the homologously recombined DNA. Knockout animals can be characterized for instance, for their ability to defend against certain pathological conditions and for their development of pathological conditions due to absence of the Factor D polypeptide.

Thus, the biological activity of potential Factor D antagonists can be further studied in murine Factor D knock-out mice.

An animal model of age-related macular degeneration (AMD) consists of mice with a null mutation in Ccl-2 or Ccr-2 gnes. These mice develop cardinal features of AMD, including accumulation of lipofuscin in and drusen beneath the retinal pigmented epithelium (RPE), photoreceptor atrophy and choroidal neovascularization (CNV). These features develop beyond 6 months of age. Candidate Factor D antagonists can be tested for the formation of drusen, photoreceptor atrophy and choroidal neovascularization.

Pharmaceutical Compositions

Therapeutic formulations of the polypeptide or antibody, or antibody fragment thereof (e.g. antigen-binding fragment), or antibody variant thereof, may be prepared for storage as lyophilized formulations or aqueous solutions by mixing the polypeptide having the desired degree of purity with optional "pharmaceutically-acceptable" carriers, excipients or stabilizers typically employed in the art (all of which are termed "excipients"). For example, buffering agents, stabilizing agents, preservatives, isotonifiers, non-ionic detergents, antioxidants and other miscellaneous additives. (See Remington's Pharmaceutical Sciences, 16th edition, A. Osol, Ed. (1980)). Such additives must be nontoxic to the recipients at the dosages and concentrations employed.

Buffering agents help to maintain the pH in the range which approximates physiological conditions. They are preferably present at concentration ranging from about 2 mM to about 50 mM. Suitable buffering agents for use with the present invention include both organic and inorganic acids and salts thereof such as citrate buffers (e.g., monosodium citrate-disodium citrate mixture, citric acid-trisodium citrate mixture, citric acid-monosodium citrate mixture, etc.), succinate buffers (e.g., succinic acid-monosodium succinate mixture, succinic acid-sodium hydroxide mixture, succinic acid-disodium succinate mixture, etc.), tartrate buffers (e.g., tartaric acid-sodium tartrate mixture, tartaric acid-potassium tartrate mixture, tartaric acid-sodium hydroxide mixture, etc.), fumarate buffers (e.g., fumaric acid-monosodium fumarate mixture, etc.), fumarate buffers (e.g., fumaric acid-monosodium fumarate mixture, fumaric acid-disodium fumarate mixture, monosodium fumarate-disodium fumarate mixture, etc.), gluconate buffers (e.g., gluconic acid-sodium glyconate mixture, gluconic acid-sodium hydroxide mixture, gluconic acid-potassium glyuconate mixture, etc.), oxalate buffer (e.g., oxalic acid-sodium oxalate mixture, oxalic acid-sodium hydroxide mixture, oxalic acid-potassium oxalate mixture, etc.), lactate buffers (e.g., lactic acid-sodium lactate mixture, lactic acid-sodium hydroxide mixture, lactic acid-potassium lactate mixture, etc.) and acetate buffers (e.g., acetic acid-sodium acetate mixture, acetic acid-sodium hydroxide mixture, etc.). Additionally, there may be mentioned phosphate buffers, histidine buffers and trimethylamine salts such as Tris.

Preservatives may be added to retard microbial growth, and may be added in amounts ranging from 0.2%- 1% (w/v). Suitable preservatives for use with the present invention include phenol, benzyl alcohol, meta-cresol, methyl paraben, propyl paraben, octadecyldimethylbenzyl ammonium chloride, benzalconium halides (e.g., chloride, bromide, iodide), hexamethonium chloride, alkyl parabens such as methyl or propyl paraben, catechol, resorcinol, cyclohexanol, and 3-pentanol.

Isotonicifiers sometimes known as "stabilizers" may be added to ensure isotonicity of liquid compositions of the present invention and include polhydric sugar alcohols, preferably trihydric or higher sugar alcohols, such as glycerin, erythritol, arabitol, xylitol, sorbitol and mannitol.

Stabilizers refer to a broad category of excipients which can range in function from a bulking agent to an additive which solubilizes the therapeutic agent or helps to prevent denaturation or adherence to the container wall. Typical stabilizers can be polyhydric sugar alcohols (enumerated above); amino acids such as arginine, lysine, glycine, glutamine, asparagine, histidine, alanine, ornithine, L-leucine, 2-phenylalanine, glutamic acid, threonine, etc., organic sugars or sugar alcohols, such as lactose, trehalose, stachyose, mannitol, sorbitol, xylitol, ribitol, myoinisitol, galactitol, glycerol and the like, including cyclitols such as inositol; polyethylene glycol; amino acid polymers; sulfur containing reducing agents, such as urea, glutathione, thioctic acid, sodium thioglycolate, thioglycerol, .alpha.-monothioglycerol and sodium thio sulfate; low molecular weight polypeptides (i.e. <10 residues); proteins such as human serum albumin, bovine serum albumin, gelatin or immunoglobulins; hydrophylic polymers, such as polyvinylpyrrolidone monosaccharides, such as xylose, mannose, fructose, glucose; disaccharides such as lactose, maltose, sucrose and trisaccacharides such as raffmose; polysaccharides such as dextran. Stabilizers may be present in the range from 0.1 to 10,000 weights per part of weight active protein.

Non-ionic surfactants or detergents (also known as "wetting agents") may be added to help solubilize the therapeutic agent as well as to protect the therapeutic protein against agitation-induced aggregation, which also permits the formulation to be exposed to shear surface stressed without causing denaturation of the protein. Suitable non-ionic surfactants include polysorbates (20, 80, etc.), polyoxamers (184, 188 etc.), Pluronic.R.TM. polyols, polyoxyethylene sorbitan monoethers (Tween.RTM.-20, Tween.R.TM.-80, etc.). Non-ionic surfactants may be present in a range of about 0.05 mg/ml to about 1.0 mg/ml, preferably about 0.07 mg/ml to about 0.2 mg/ml.

Additional miscellaneous excipients include bulking agents, (e.g. starch), chelating agents (e.g. EDTA), antioxidants (e.g., ascorbic acid, methionine, vitamin E), and cosolvents. The formulation herein may also contain more than one active compound as necessary for the particular indication being treated, preferably those with complementary activities that do not adversely affect each other. For example, it may be desireable to further provide an immunosuppressive agent. Such molecules are suitably present in combination in amounts that are effective for the purpose intended. The active ingredients may also be entrapped in microcapsule prepared, for example, by coascervation techniques or by interfacial polymerization, for example, hydroxymethylcellulose or gelatin-microcapsule and poly- (methylmethacylate) microcapsule, respectively, in colloidal drug delivery systems (for example, liposomes, albumin micropheres, microemulsions, nano-particles and nanocapsules) or in macroemulsions. Such techniques are disclosed in Remington 's Pharmaceutical Sciences, 16th edition, A. Osal, Ed. (1980).

The formulations to be used for in vivo administration must be sterile. This is readily accomplished, for example, by filtration through sterile filtration membranes. Sustained-release preparations may be prepared. Suitable examples of sustained-release preparations include semipermeable matrices of solid hydrophobic polymers containing the antibody, or antibody variant or fragment (e.g. antigen-binding fragment) thereof, which matrices are in the form of shaped articles, e.g., films, or microcapsules. Examples of sustained-release matrices include polyesters, hydrogels (for example, poly(2-hydroxyethyl-methacrylate), or poly(vinylalcohol)), polylactides (U.S. Pat. No. 3,773,919), copolymers of L-glutamic acid and ethyl-L-glutamate, non- degradable ethylene -vinyl acetate, degradable lactic acid-glycolic acid copolymers such as the LUPRON DEPOT™ (injectable microspheres composed of lactic acid-glycolic acid copolymer and leuprolide acetate), and poly-D-(-)-3-hydroxybutyric acid. While polymers such as ethylene- vinyl acetate and lactic acid-glycolic acid enable release of molecules for over 100 days, certain hydrogels release proteins for shorter time periods. When encapsulated antibodies remain in the body for a long time, they may denature or aggregate as a result of exposure to moisture at 37 °C resulting in a loss of biological activity and possible changes in immunogenicity. Rational strategies can be devised for stabilization depending on the mechanism involved. For example, if the aggregation mechanism is discovered to be intermolecular S--S bond formation through thio- disulfide interchange, stabilization may be achieved by modifying sulfhydryl residues, lyophilizing from acidic solutions, controlling moisture content, using appropriate additives, and developing specific polymer matrix compositions.

The compounds that can be identified by the method of the present invention for prevention or treatment of an ocular disease or condition are typically administered by ocular, intraocular, and/or intravitreal injection, and/or juxtascleral injection, and/or subtenon injection, and/or superchoroidal injection and/or topical administration in the form of eyedrops and/or ointment. Such compounds of the invention may be delivered by a variety of methods, e.g. intravitreally as a device and/or a depot that allows for slow release of the compound into the vitreous, including those described in references such as Intraocular Drug Delivery, Jaffe, Jaffe, Ashton, and Pearson, editors, Taylor & Francis (March 2006). In one example, a device may be in the form of a minpump and/or a matrix and/or a passive diffusion system and/or encapsulated cells that release the compound for a prolonged period of time (Intraocular Drug Delivery, Jaffe, Jaffe, Ashton, and Pearson, editors, Taylor & Francis (March 2006). Other methods of administration may also be used, which includes but is not limited to, topical, parenteral, subcutaneous, intraperitoneal, intrapulmonary, intranasal, and intralesional administration. Parenteral infusions include intramuscular, intravenous, intraarterial, intraperitoneal, or subcutaneous administration.

Formulations for ocular, intraocular or intravitreal administration can be prepared by methods and using ingredients known in the art. A main requirement for efficient treatment is proper penetration through the eye. Unlike diseases of the front of the eye, where drugs can be delivered topically, retinal diseases require a more site-specific approach. Eye drops and ointments rarely penetrate the back of the eye, and the blood-ocular barrier hinders penetration of systemically administered drugs into ocular tissue. Accordingly, usually the method of choice for drug delivery to treat retinal disease, such as AMD and CNV, is direct intravitreal injection. Intravitrial injections are usually repeated at intervals which depend on the patient's condition, and the properties and half-life of the drug delivered. For intraocular (e.g. intravitreal) penetration, usually molecules of smaller size are preferred. The efficacy of the treatment of complement-associated eye conditions, such as AMD or CNV, can be measured by various endpoints commonly used in evaluating intraocular diseases. For example, vision loss can be assessed. Vision loss can be evaluated by, but not limited to, e.g., measuring by the mean change in best correction visual acuity (BCVA) from baseline to a desired time point (e.g., where the BCVA is based on Early Treatment Diabetic Retinopathy Study (ETDRS) visual acuity chart and assessment at a test distance of 4 meters), measuring the proportion of subjects who lose fewer than 15 letters in visual acuity at a desired time point compared to baseline, measuring the proportion of subjects who gain greater than or equal to 15 letters in visual acuity at a desired time point compared to baseline, measuring the proportion of subjects with a visual-acuity Snellen equivalent of 20/2000 or worse at a desired time point, measuring the NEI Visual Functioning Questionnaire, measuring the size of CNV and amount of leakage of CNV at a desired time point, e.g., by fluorescein angiography, etc. Ocular assessments can be done, e.g., which include, but are not limited to, e.g., performing eye exam, measuring intraocular pressure, assessing visual acuity, measuring slitlamp pressure, assessing intraocular inflammation, etc.

The amount of therapeutic polypeptide, antibody, or antibody variant thereof, or fragment thereof (e.g antigen-binding fragment) which will be effective in the treatment of a particular disorder or condition will depend on the nature of the disorder or condition, and can be determined by standard clinical techniques. Where possible, it is desirable to determine the dose- response curve and the pharmaceutical compositions of the invention first in vitro, and then in useful animal model systems prior to testing in humans.

In one embodiment, an aqueous solution of therapeutic polypeptide, antibody, or antibody variant thereof, or fragment thereof (e.g. antigen-binding fragment), is administered by subcutaneous injection. In another embodiment, an aqueous solution of therapeutic polypeptide, antibody, or antibody variant thereof, or fragment thereof (e.g. antigen-binding fragment) is administered by intravitreal injection. Each dose may range from about 0.5 .mu.g to about 50 .mu.g per kilogram of body weight, or more preferably, from about 3 .mu.g to about 30 .mu.g per kilogram body weight.

The dosing schedule for subcutaneous administration may vary form once a month to daily depending on a number of clinical factors, including the type of disease, severity of disease, and the subject's sensitivity to the therapeutic agent.

The following examples are offered for illustrative purposes only, and are not intended to limit the scope of the present invention in any way. All patent and literature references cited in the present specification are hereby expressly incorporated by reference in their entirety.

Example 1

Determination of Co-Crystal Structure of Factor D and Anti-Factor D Antibody

Both human and cyno factor D were expressed in Chinese Hamster Ovary (CHO) cells.

Purification was performed by passing the CHO cell supernatant over an anti-Factor D affinity column. Proteins were eluted with 0.1 M acidic and with 4% v/v 1.5 M Tris pH 8.6 and dialyzed in a buffer containing 10 mM Hepes pH 7.2 with 140 mM NaCl. Anti-factor D Fab were provided in lyophilized formulation and reconstituted with water. Resulting solution is

50mg/mL protein in 40 mM Histidine Hydrochloride, 20 mM Sodium Chloride, 180 mM

Sucrose, 0.04% (w/v) polysorbate 20, pH 5.4.

Human factor D protein and anti-factor D Fab were mixed 1 : 1 ratio and purified over a Superdex 200 column pre-equilibrated with 20 mM hepes, pH 7.2 and 200 mM NaCl. The peak fractions containing the complex were pooled, concentrated to 30 mg/ml and used in

crystallization trial. Crystals were grown at 4°C using vapor diffusion method in sitting drops. Crystallization buffer containing 0.1 M TrisCl, pH 8.5, 0.2 M ammonium phosphate, 50% MPD and 0.01 M hexamine cobalt (III) chloride was mixed in equal volume with protein solution. Crystals appeared after 6 days and belonged to space group P4 ₃ 2i2. The crystals were flash frozen in liquid nitrogen. A 2.4 A data set was collected at SSRL Synchrotron Source on beam line 9-2.

The cyno factor D/anti-factor D Fab complex was purified following the same protocol as described above. Crystals used in the structure determination were grown at 19°C from the following condition: 0.1 M MES pH 6.5, 25% PEG 550 MME, 0.01 M zinc sulfate and 3% 6- aminohexanoic acid using vapor diffusion method in sitting drops containing equal volume of protein solution (20 mg/ml) and mother liquor. The crystals appeared after 1 day and belonged to space group C2 with cell dimensions of a=132.048, b=132.048; c=180.288 A for human Factor D:Fab complex, and a=l 82.205; b=80.673; c=142.575 A for cyno factor D:Fab complex. The crystals were dipped in artificial mother liquor containing 10% glycerol and flash frozen in liquid nitrogen. A 2.1 A data set was collected at an SSRL Synchrotron Source on beam line 9-2. Example 2

Preparation of catalytically inactive Factor D protein

Full-length factor D cDNA was cloned into a pR expression vector. Residue S208 (from starting methionine; SI 95 using trypsin numbering), which is part of the catalytic triad, was mutated to an alanine using QuickChange XL Site Directed Mutagenesis kit following manufactures instructions (Stratagene (Agilent), Santa Clara, CA). Protein was expressed in CHO cells and purified by passing supernatant multiple times over an Affi-Gel 10 (Bio-Rad) coupled with 26 mg/ml anti-Factor D antibody and eluted at pH 3.0. Proteins were further purified using a secondary 10/10 MonoS pH 6.0 column, concentrated with an Amicon Ultra-10 kD centrifugation filter (Millipore, Billerica, MA) and dialyzed in PBS. Protein sequence was verified with N-terminal sequencing using MALDI mass spectrometry.

Example 3

Blocking of factor B cleavage by anti-Factor D antibody in a fluid phase alternative pathway C3 convertase assay

The assay buffer was 0.1% gelatin veronal buffer/ 10 mM MgCl _2, , final concentration of components were 0.125 μΜ Factor D, 0.5 μΜ factor B, 0.5 μΜ C3b and 5 μΜ Fab antibodies (anti-Factor D, 8E2, control human Fab). 10 μΐ Factor D (0.5 μΜ) and 10 μΐ Fab (20 μΜ) were mixed for 15 min. 10 μΐ Factor B (2 μΜ) and 10 μΐ C3b (2 μΜ) were added to Factor D-Fab mixture and incubated for 30 minutes at 37C. 40 μΐ Lammeli's buffer was added to stop the reaction. Samples were boiled for 5 minutes and run on a Novex 4-20% Tris-glycine polyacrylamide gel for 1.5 hours at 125 mV (SeeBlue2 MW marker). Gels were stained for one hour with SimplyBlue SafeStain, washed overnight with double distilled water and dried between Cellophane. As shown in Figure 21, factor B cleavage was blocked by the anti-Factor D antibody but not by 8E2 . The results show that the anti-factor D antibody blocks cleavage of factor B in a fluid phase alternative pathway C3 convertase assay.

Example 4

Factor D (S208A) binds pro-convertase with an affinity of 772 nM (Bioacore analysis) Binding analysis was performed on Biacore 3000. C3b was amine coupled to CM5 chip following manufacturer's recommendation. The CM5 chip was activated with N-hydroxyl succinimide and N-ethyl-N'-(dimethylaminopropyl)-carbodiimide, flow 5 μΐ/min, 30 μΐ. C3b (50 μg/ml) was flowed for 5 μΐ/min, 20 μΐ to achieve 7300 RU final. Factor B, Factor D, anti- Factor D antibody and 8E2 Fab fragment proteins and antibodies were buffer exchanged using GE Healthcare's AKTA in assay buffer: veronal buffer/1 mM NiCl ₂ /0.05% Surfactant P-20. Binding assays used "Coinject" program. One μΜ factor B was injected (flow 30 μΐ/minute, 90 μΐ) followed by coinject mix of 1 μΜ factor B and Factor D dilutions (flow 30 μΐ/minute, 90 μΐ) then allowed to dissociate in assay buffer for 5 minutes. Chip was regenerated with three, one minute washes with 3 M NaCl in 50 mM sodium acetate pH 5.0 and washed 5 minutes with buffer. As shown in Figures 22 and 23, Factor (S208A) binds to C3bB pro-convertase with an affinity of 772 nM as determined by this Biacore analysis.

Example 5

Anti-Factor D antibody blocks Factor D binding

Binding analysis was performed on Biacore 3000. C3b was amine coupled to CM5 chip following manufacturer's recommendation. The CM5 chip was activated with N-hydroxyl succinimide and N-ethyl-N'-(dimethylaminopropyl)-carbodiimide, flow 5 μΐ/min, 30 μΐ. C3b (50 μg/ml) was flowed for 5 μΐ/min, 20 μΐ to achieve 6020 RU final. Factor B, factor D, anti- Factor D antibody and 8E2 Fab fragment proteins and antibodies were buffer exchanged using GE Healthcare's AKTA in assay buffer: veronal buffer/1 mM NiCl ₂ /0.05% Surfactant P-20.

Binding assays used "Coinject" program. One μΜ factor B was injected (flow 30 μΐ/minute, 90 μΐ) followed by coinject mix of 1 μΜ factor B, 1 μΜ Factor D and Fab antibody dilutions (flow 30 μΐ/minute, 90 μΐ) then allowed to dissociate in assay buffer for 5 minutes. Chip was regenerated with three, one-minute washes with 3 M NaCl in 50 mM sodium acetate pH 5.0 and washed 5 minutes with buffer. As shown in Figures 24 and 25, the anti-Factor D antibody blocked Factor D (S208A) binding to C3bB pro-convertase.

Example 5

Anti-Factor D antibody does not affect catalytic cleavage

Small substrates are efficiently cleaved by Factor D bound to anti-Factor D antibody confirming the absence of major conformational changes in the Factor D active site. Factor D hydrolysis of thioester benzyl substrate Z-Lys-SBzl was measured using DTNB (Ellman's reagent (5,5'-dithiobis-(2-nitrobenzoic acid)) in assay buffer 50 mM HEPES pH7.5/220 mM NaCl. Stock solutions of 3.2 mM Z-lys-SBzl in DMSO (dimethyl sulfoxide), 320 nM Factor D proteins (Genentech), 3.2 μΜ antibodies and 8 mM DTNB in assay buffer, and 200 mM DIFP (diisopropyl fluorophosphates) in isopropanol were made. Assay volume was 200 μΐ in assay buffer with final concentrations of 2 mM DTNB, 800 nM Z-Lys-SBzl, 80 nM Factor D, 800 uM antibodies or 20 mM DIFP. Hydro losis rates were measured in a Spectramax Plus 384 spectrophotometer at 450 nm for 1.5 hours, readings taken every 15 seconds and Vmax calculated using SoftMax Pro v5.2 software. Figures 26 and 27 show that the anti-Factor D antibody does not affect catalytic cleavage. Figure 28 is a hypothetical model depicting how an anti-Factor D antibody inhibits Factor B activation. The anti-Factor D antibody sterically inhibits docking of Factor D to factor B, preventing activation of factor B and formation of an active C3 convertase.

human fD_Fab

Appendi x lA: Structural coord nates human factor D anti factor D Fab

REMARK 3 REFINEMENT.

REMARK 3 PROGRAM REFMAC 5.2.0019

REMARK 3 AUTHORS MURSHUDOV , VAGIN , DODSON

REMARK 3

REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD

REMARK 3

REMARK 3 DATA USED IN REFINEMENT.

REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS 2.42

REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS 20.00

REMARK 3 DATA CUTOFF (SIGMA(F) NONE

REMARK 3 COMPLETENESS FOR RANGE ( 98.65

REMARK 3 NUMBER OF REFLECTIONS 57310

REMARK 3

REMARK 3 FIT TO DATA USED IN REFINEMENT.

REMARK 3 CROSS-VALIDATION METHOD THROUGHOUT

REMARK 3 FREE R VALUE TEST SET SELECTION RANDOM

REMARK 3 R VALUE (WORKING + TEST SET) 0.21584

REMARK 3 R VALUE (WORKING SET) 0.21286

REMARK 3 FREE R VALUE 0.27248

REMARK 3 FREE R VALUE TEST SET SIZE (%) 5.1

REMARK 3 FREE R VALUE TEST SET COUNT 3064

REMARK 3

REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.

REMARK 3 TOTAL NUMBER OF BINS USED 25

REMARK 3 BIN RESOLUTION RANGE HIGH 2.420

REMARK 3 BIN RESOLUTION RANGE LOW 2.469

REMARK 3 REFLECTION IN BIN (WORKING SET) 3329

REMARK 3 BIN COMPLETENESS (WORKI G+TEST) (%) 99.35

REMARK 3 BIN R VALUE (WORKING SET) 0.298

REMARK 3 BIN FREE R VALUE SET COUNT 174

REMARK 3 BIN FREE R VALUE 0.413

REMARK 3

REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.

REMARK 3 ALL ATOMS : 10273

REMARK 3

REMARK 3 B VALUES.

REMARK 3 FROM WILSON PLOT (A**2 NULL

REMARK 3 MEAN B VALUE (OVERALL, A**2 38.909

REMARK 3 OVERALL ANISOTROPIC B VALUE .

REMARK 3 Bll A**2 -2.06

REMARK 3 B22 A**2 -2.06

REMARK 3 B33 A**2 4.11

REMARK 3 B12 A**2 0.00

REMARK 3 B13 A**2 0.00

REMARK 3 B23 A**2: 0.00

REMARK 3

REMARK 3 ESTIMATED OVERALL COORDINATE ERROR.

REMARK 3 ESU BASED ON R VALUE A) : 0.419 REMARK 3 ESU BASED ON FREE R VALUE A): 0.285 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD A): 0.220 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD (A* 2): 18.683 REMARK 3

REMARK 3 CORRELATION COEFFICIENTS.

REMARK 3 CORRELATION COEFFICIENT FO-FC : 0.944

REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.914

REMARK 3

REMARK 3 RMS DEVIATIONS FROM IDEAL VALUES RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A 0 .012 0.022 REMARK 3 BOND LENGTHS OTHERS (A 0 .002 0.020 REMARK 3 BOND ANGLES REFINED ATOMS (DEGREES 1 .421 1.959 REMARK 3 BOND ANGLES OTHERS (DEGREES 0 .940 3.004 REMARK 3 TORSION ANGLES, PERIOD 1 (DEGREES 9 .697 5.000 REMARK 3 TORSION ANGLES, PERIOD 2 (DEGREES 37 .347 24.279 REMARK 3 TORSION ANGLES, PERIOD 3 (DEGREES 17 .488 15.000 REMARK 3 TORSION ANGLES, PERIOD 4 (DEGREES 16 .500 15.000 REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3 0 .079 0.200 human fD_Fab

REMARK 3 GENERAL PLANES REFINED ATOMS 11375 0.005 0.020

REMARK 3 GENERAL PLANES OTHERS 1933 0.002 0.020

REMARK 3 NON-BONDED CONTACTS REFINED ATOMS 1764 0.201 0.200

REMARK 3 NON-BONDED CONTACTS OTHERS 7017 0.201 0.200

REMARK 3 NON-BONDED TORSION REFINED ATOMS 4720 0.173 0.200

REMARK 3 NON-BONDED TORSION OTHERS 5711 0.086 0.200

REMARK 3 H-BOND (X...Y) REFINED ATOMS 423 0.175 0.200

REMARK 3 H-BOND (X...Y OTHERS 3 0.207 0.200

REMARK 3 SYMMETRY VDW REFINED ATOMS 29 0.218 0.200

REMARK 3 SYMMETRY VDW OTHERS 88 0.259 0.200

REMARK 3 SYMMETRY H-BOND REFINED ATOMS 12 0.284 0.200

REMARK 3

REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT

REMARK 3 MAIN-CHAIN BOND REFINED ATOMS A**2 8380 3.169 2.500

REMARK 3 MAIN-CHAIN BOND OTHER ATOMS A**2; 2669 0.624 2.500

REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS A**2; 10576 4.155 5.000

REMARK 3 SIDE-CHAIN BOND REFINED ATOMS A**2: 4199 3.191 2.500

REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS A**2: 3270 4.451 5.000

REMARK 3

REMARK 3 NCS RESTRAINTS STATISTICS

REMARK 3 NUMBER OF DIFFERENT NCS GROUPS :

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3 WEIGHT

REMARK 3 0.05

REMARK 3 5.00

REMARK 3 0.50

REMARK 3 10.00

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3

REMARK 3 WEIGHT

REMARK 3 0.05

REMARK 3 5.00

REMARK 3 0.50

REMARK 3 10.00

REMARK 3

REMARK 3 NCS GROUP NUMBER :

REMARK 3 CHAIN NAMES : H E

REMARK 3 NUMBER OF COMPONENTS NCS GROUP : 2

REMARK 3 COMPONENT C SSSEQI TO C SSSEQI CODE

REMARK 3 1 H 1 H 120 3

REMARK 3 1 E 1 E 120 3

REMARK 3 2 H 121 H 224 3

REMARK 3 2 E 121 E 224 3

REMARK 3 GROUP C COUNT RMS WEIGHT

REMARK 3 TIGHT POSITIONAL 3 1262 0.07 0.05

REMARK 3 LOOSE POSITIONAL 3 1444 0.52 5.00

REMARK 3 TIGHT THERMAL 3 1262 0.14 0.50

REMARK 3 LOOSE THERMAL 3 1444 2.53 10.00

REMARK 3

REMARK 3

REMARK 3 TLS DETAILS

REMARK 3 NUMBER OF TLS GROUPS

REMARK 3 ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY

REMARK 3

REMARK 3 TLS GROUP : 1 human fD_Fab

REMARK 3 NUMBER OF COMPONENTS GROUP : 10

REMARK 3 COMPONENTS C SSSEQI TO c SSSEQI REMARK 3 RESIDUE RANGE A 16 A 243 REMARK 3 RESIDUE RANGE L 1 L 109 REMARK 3 RESIDUE RANGE L 110 L 214

REMARK 3 RESIDUE RANGE H 1 H 120

REMARK 3 RESIDUE RANGE H 121 H 224

REMARK 3 RESIDUE RANGE B 16 B 243 REMARK 3 RESIDUE RANGE D 1 D 109

REMARK 3 RESIDUE RANGE D 110 D 214

REMARK 3 RESIDUE RANGE E 1 E 120

REMARK 3 RESIDUE RANGE E 121 E 224

REMARK 3 ORIGIN FOR THE GROUP (A) : - 29.9532 3.2516 -32.8996 REMARK 3 TENSOR

REMARK 3 Til: 0.0677 T22 -0.0717

REMARK 3 T33 0.0051 T12 0.0211

REMARK 3 T13 0.0318 T23 0.0562

REMARK 3 L TENSOR

REMARK 3 Lll: 0.0559 L.22 0.1507

REMARK 3 L33: 0.2071 L12 -0.0360

REMARK 3 L13: -0.0974 L23 0.1319

REMARK 3 S TENSOR

REMARK 3 Sll: -0.0182 S12 -0.0019 S13: 0.0558 REMARK 3 S21: -0.0609 S22 -0.0301 S23: 0.0813 REMARK 3 S31: -0.0569 S32 -0.1069 S33: 0.0484 REMARK 3

REMARK 3

REMARK 3 BULK SOLVENT MODELLING.

REMARK 3 METHOD USED : MASK

REMARK 3 PARAMETERS FOR MASK CALCULATION

REMARK 3 VDW PROBE RADIUS 1.40

REMARK 3 ION PROBE RADIUS 0.80

REMARK 3 SHRINKAGE RADIUS 0.80

REMARK 3

REMARK 3 OTHER REFINEMENT REMARKS :

REMARK 3 HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS REMARK 3

SSBOND 1 CYS A 41 CYS A 57

SSBOND 2 CYS A 138 CYS A 204

SSBOND 3 CYS A 169 CYS A 185

SSBOND 4 CYS A 194 CYS A 219

SSBOND 5 CYS L 23 CYS L 88

SSBOND 6 CYS L 134 CYS L 194

SSBOND 7 CYS H 22 CYS H 96

SSBOND 8 CYS H 148 CYS H 204

SSBOND 9 CYS B 41 CYS B 57

SSBOND 10 CYS B 138 CYS B 204

SSBOND 11 CYS B 169 CYS B 185

SSBOND 12 CYS B 194 CYS B 219

SSBOND 13 CYS E 22 CYS E 96

SSBOND 14 CYS E 148 CYS E 204

SSBOND 15 CYS D 23 CYS D 88

SSBOND 16 CYS D 134 CYS D 194

SSBOND 17 CYS L 214 CYS H 224

CISPEP 1 ALA A 61 ALA A 62 0.00

CISPEP 2 SER L 7 PRO L 8 0.00 CISPEP 3 LEU L 94 PRO L 95 0.00

CISPEP 4 TYR L 140 PRO L 141 0.00

CISPEP 5 GLU H 99 GLY H 100 0.00

CISPEP 6 PHE H 154 PRO H 155 0.00

CISPEP 7 GLU H 156 PRO H 157 0.00

CISPEP 8 ARG B 151 ARG B 152 0.00

CISPEP 9 GLU E 99 GLY E 100 0.00

CISPEP 10 PHE E 154 PRO E 155 0.00

CISPEP 11 GLU E 156 PRO E 157 0.00

CISPEP 12 SER D 7 PRO D 8 0.00

CISPEP 13 LEU D 94 PRO D 95 0.00

CISPEP 14 TYR D 140 PRO D 141 0.00 human fD_Fab

LINK C GLY H 101 N VAL H 108 TRANS

LINK C GLY E 101 N VAL E 108 TRANS

CRYSTl 132. ,048 132 .048 180.; 288 90. 00 90.00 90.00 P 43 21 2

SCALEl 0.007573 0 .000000 0.000000 0.00000

SCALE2 0.000000 0 .007573 0.000000 0.00000

SCALE3 0.000000 0 .000000 0.005547 0.00000

ATOM 1 N ILE A 16 -35.933 24.398 8.493 1.00 36. 83 A N

ATOM 2 CA ILE A 16 -36.360 23.498 7.363 1.00 41. 06 A C

ATOM 4 CB ILE A 16 -37.627 22.666 7.743 1.00 34. 42 A C

ATOM 6 CGI ILE A 16 -37.370 21.869 9.023 1.00 32. 96 A c

ATOM 9 CDl ILE A 16 -36.159 20.919 8.948 1.00 27. 50 A c

ATOM 13 CG2 ILE A 16 -38.055 21.731 6.587 1.00 32. 42 A c

ATOM 17 C ILE A 16 -36.638 24.279 6.067 1.00 41. 65 A c

ATOM 18 O ILE A 16 -37.532 25.114 6.024 1.00 40. 98 A 0

ATOM 22 N LEU A 17 -35.864 23.993 5.023 1.00 43. 46 A N

ATOM 23 CA LEU A 17 -35.991 24.686 3.739 1.00 43. 61 A c

ATOM 25 CB LEU A 17 -34.611 25.096 3.210 1.00 42. 45 A c

ATOM 28 CG LEU A 17 -34.473 25.839 1.879 1.00 42. 83 A c

ATOM 30 CDl LEU A 17 -33.414 26.949 2.005 1.00 45. 73 A c

ATOM 34 CD2 LEU A 17 -34.102 24.909 0.733 1.00 37. 92 A c

ATOM 38 C LEU A 17 -36.686 23.786 2.736 1.00 43. 19 A c

ATOM 39 O LEU A 17 -36.436 22.586 2.693 1.00 39. 42 A 0

ATOM 41 N GLY A 18 -37.579 24.376 1.941 1.00 43. 33 A N

ATOM 42 CA GLY A 18 -38.346 23.633 0.963 1.00 44. 58 A c

ATOM 45 C GLY A 18 -39.255 22.603 1.602 1.00 46. 38 A c

ATOM 46 O GLY A 18 -39.563 21.580 1.004 1.00 46. 62 A 0

ATOM 48 N GLY A 19 -39.690 22.881 2.821 1.00 49. 02 A N

ATOM 49 CA GLY A 19 -40.616 22.016 3.517 1.00 52. 22 A C

ATOM 52 C GLY A 19 -41.939 22.738 3.649 1.00 55. 09 A C

ATOM 53 O GLY A 19 -42.236 23.661 2.880 1.00 52. 71 A 0

ATOM 55 N ARG A 20 -42.724 22.321 4.635 1.00 55. 28 A N

ATOM 56 CA ARG A 20 -44.012 22.941 4.907 1.00 58. 38 A C

ATOM 58 CB ARG A 20 -45.077 22.319 4.017 1.00 63. 11 A C

ATOM 61 CG ARG A 20 -45.396 20.887 4.354 1.00 64. 33 A C

ATOM 64 CD ARG A 20 -45.978 20.194 3.154 1.00 68. 28 A c

ATOM 67 NE ARG A 20 -46.607 18.929 3.511 1.00 72. 11 A N

ATOM 69 CZ ARG A 20 -47.381 18.221 2.696 1.00 74. 91 A c

ATOM 70 NHl ARG A 20 -47.629 18.649 1.458 1.00 76. 67 A N

ATOM 73 NH2 ARG A 20 -47.911 17.077 3.118 1.00 74. 61 A N

ATOM 76 C ARG A 20 -44.379 22.749 6.364 1.00 55. 89 A c

ATOM 77 O ARG A 20 -43.754 21.946 7.051 1.00 54. 18 A 0

ATOM 79 N GLU A 21 -45.389 23.485 6.824 1.00 53. 26 A N

ATOM 80 CA GLU A 21 -45.786 23.456 8.231 1.00 51. 44 A C

ATOM 82 CB GLU A 21 -46.968 24.386 8.502 1.00 50. 34 A C

ATOM 85 CG GLU A 21 -47.146 24.710 9.982 1.00 49. 81 A c

ATOM 88 CD GLU A 21 -48.394 25.525 10.277 1.00 49. 85 A c

ATOM 89 OEl GLU A 21 -48.805 26.356 9.427 1.00 46. 48 A 0

ATOM 90 OE2 GLU A 21 -48.955 25.335 11.377 1.00 44. 76 A 0

ATOM 91 C GLU A 21 -46.172 22.062 8.690 1.00 48. 95 A c

ATOM 92 O GLU A 21 -46.926 21.348 8.014 1.00 48. 12 A 0

ATOM 94 N ALA A 22 -45.676 21.686 9.859 1.00 47. 00 A N

ATOM 95 CA ALA A 22 -46.043 20.423 10.461 1.00 47. 91 A c

ATOM 97 CB ALA A 22 -45.055 20.055 11.535 1.00 44. 41 A c

ATOM 101 C ALA A 22 -47.472 20.504 11.025 1.00 50. 30 A c

ATOM 102 O ALA A 22 -47.977 21.595 11.336 1.00 46. 54 A 0

ATOM 104 N GLU A 23 -48.132 19.352 11.121 1.00 52. 50 A N

ATOM 105 CA GLU A 23 -49.432 19.266 11.787 1.00 51. 01 A c

ATOM 107 CB GLU A 23 -50.137 17.939 11.493 1.00 54. 61 A c

ATOM 110 CG GLU A 23 -51.582 17.847 12.059 1.00 57. 03 A c

ATOM 113 CD GLU A 23 -52.046 16.406 12.309 1.00 58. 09 A c

ATOM 114 OEl GLU A 23 -51.696 15.515 11.499 1.00 60. 27 A 0

ATOM 115 OE2 GLU A 23 -52.758 16.167 13.313 1.00 55. 07 A 0

ATOM 116 C GLU A 23 -49.185 19.419 13.281 1.00 49. ,17 A c

ATOM 117 0 GLU A 23 -48.361 18.709 13.858 1.00 49. ,61 A 0

ATOM 119 N ALA A 24 -49.890 20.358 13.895 1.00 49. 19 A N

ATOM 120 CA ALA A 24 -49.694 20.695 15.300 1.00 46. 33 A c

ATOM 122 CB ALA A 24 -50.772 21.641 15.766 1.00 39. ,76 A c

ATOM 126 C ALA A 24 -49.652 19.477 16.198 1.00 46. ,69 A c human fD_Fab

ATOM 127 O ALA A 24 -50. 564 18. .660 16. ,192 1.00 50. ,29 A 0

ATOM 129 N HIS A 25 -48. 558 19. ,345 16. 938 1.00 49. ,73 A N

ATOM 130 CA HIS A 25 -48. 395 18. ,314 17. 966 1.00 48. ,10 A C

ATOM 132 CB HIS A 25 -49. 397 18. ,567 19. 099 1.00 43. ,11 A C

ATOM 135 CG HIS A 25 -49. 495 20. ,008 19. ,511 1.00 37. ,95 A C

ATOM 136 NDl HIS A 25 -50. 596 20. ,786 19. ,225 1.00 34. 73 A N

ATOM 138 CEl HIS A 25 -50. 405 22. ,007 19. ,694 1.00 36. 64 A C

ATOM 140 NE2 HIS A 25 -49. 218 22. ,050 20. ,275 1.00 34. ,83 A N

ATOM 142 CD2 HIS A 25 -48. 627 20. .816 20.171 1.00 32. ,01 A C

ATOM 144 C HIS A 25 -48. 464 16. ,859 17. ,453 1.00 47. ,71 A C

ATOM 145 0 HIS A 25 -48. 643 15. .936 18. 235 1.00 46. ,96 A 0

ATOM 147 N ALA A 26 -48. 298 16. ,670 16. ,143 1.00 49. ,94 A N

ATOM 148 CA ALA A 26 -48. 220 15. ,344 15. 525 1.00 49. 10 A c

ATOM 150 CB ALA A 26 -48. 396 15. ,463 14. 006 1.00 45. 29 A c

ATOM 154 C ALA A 26 -46. 883 14. ,661 15. ,855 1.00 48. 93 A c

ATOM 155 O ALA A 26 -46. 753 13. ,450 15. ,710 1.00 46. 39 A 0

ATOM 157 N ARG A 27 -45. 894 15. ,458 16. ,274 1.00 50. 65 A N

ATOM 158 CA ARG A 27 -44. 578 14. ,957 16. 700 1.00 48. 98 A c

ATOM 160 CB ARG A 27 -43. 462 15. ,571 15. ,856 1.00 45. ,34 A c

ATOM 163 CG ARG A 27 -43. 455 15. .075 14. ,440 1.00 42. ,94 A c

ATOM 166 CD ARG A 27 -42. 647 15. ,958 13. ,495 1.00 46. ,79 A c

ATOM 169 NE ARG A 27 -42. 858 15. ,535 12. ,101 1.00 48. ,58 A N

ATOM 171 CZ ARG A 27 -43. 946 15, ,803 11. ,381 1.00 48. ,45 A c

ATOM 172 NHl ARG A 27 -44. 941 16. ,518 11. ,889 1.00 53. ,38 A N

ATOM 175 NH2 ARG A 27 -44. 044 15. ,367 10. ,141 1.00 49. 31 A N

ATOM 178 C ARG A 27 -44. 387 15. ,319 18. ,159 1.00 46. 44 A c

ATOM 179 O ARG A 27 -43. 764 16. ,322 18. 473 1.00 45. 92 A 0

ATOM 181 N PRO A 28 -44. 975 14. ,528 19. 060 1.00 46. 69 A N

ATOM 182 CA PRO A 28 -44. 983 14. .892 20. ,481 1.00 47. ,13 A C

ATOM 184 CB PRO A 28 -45. 903 13. ,831 21. ,113 1.00 43. 80 A C

ATOM 187 CG PRO A 28 -45. 864 12. ,701 20. ,182 1.00 45. ,08 A c

ATOM 190 CD PRO A 28 -45. 705 13. ,277 18. ,813 1.00 42. ,33 A c

ATOM 193 C PRO A 28 -43. 599 14. ,902 21. ,130 1.00 47. ,05 A c

ATOM 194 O PRO A 28 -43. 431 15. ,489 22. ,202 1.00 43. ,54 A 0

ATOM 195 N TYR A 29 -42. 632 14. ,259 20. ,467 1.00 46. ,51 A N

ATOM 196 CA TYR A 29 -41. 254 14. ,208 20. ,917 1.00 43. ,60 A c

ATOM 198 CB TYR A 29 -40. 548 13. ,034 20. ,252 1.00 41. ,11 A c

ATOM 201 CG TYR A 29 -40. 682 13. ,000 18. ,747 1.00 41. 48 A c

ATOM 202 CDl TYR A 29 -39. 857 13. .789 17. ,923 1.00 40. 62 A c

ATOM 204 CEl TYR A 29 -39. 991 13, ,762 16. ,537 1.00 38. ,60 A c

ATOM 206 CZ TYR A 29 -40. 946 12. .948 15. ,964 1.00 39. ,38 A c

ATOM 207 OH TYR A 29 -41. 085 12, ,894 14. ,602 1.00 40. ,04 A 0

ATOM 209 CE2 TYR A 29 -41.769 12. .169 16. ,754 1.00 40. ,97 A c

ATOM 211 CD 2 TYR A 29 -41. 631 12. ,192 18. 139 1.00 39. ,73 A c

ATOM 213 C TYR A 29 -40. 465 15. .485 20. 643 1.00 45. ,20 A c

ATOM 214 0 TYR A 29 -39. 355 15. ,625 21. ,154 1.00 45. ,79 A 0

ATOM 216 N MET A 30 -41. 017 16. ,406 19. ,847 1.00 42. ,74 A N

ATOM 217 CA MET A 30 -40. 245 17. ,547 19. ,373 1.00 42. ,90 A c

ATOM 219 CB MET A 30 -40. 876 18, ,150 18. ,119 1.00 41. ,27 A c

ATOM 222 CG MET A 30 -39. 958 19. .151 17. ,415 1.00 40. ,22 A c

ATOM 225 SD MET A 30 -38. 685 18, ,384 16. ,382 1.00 40. ,38 A S

ATOM 226 CE MET A 30 -37. 448 19, ,673 16. .488 1.00 34. ,09 A c

ATOM 230 C MET A 30 -40. 047 18, .618 20. ,438 1.00 43. ,81 A c

ATOM 231 0 MET A 30 -41. 000 19, ,091 21. ,039 1.00 51. ,68 A 0

ATOM 233 N ALA A 31 -38. 794 19, .003 20. ,647 1.00 42. ,74 A N

ATOM 234 CA ALA A 31 -38. 432 19, ,985 21. ,647 1.00 39. ,26 A c

ATOM 236 CB ALA A 31 -37. 511 19. ,362 22. ,647 1.00 37. ,15 A c

ATOM 240 C ALA A 31 -37. 763 21. .207 21. ,012 1.00 38. ,04 A c

ATOM 241 0 ALA A 31 -37. 117 21. ,118 19. ,972 1.00 40. ,16 A 0

ATOM 243 N SER A 32 -37. 949 22. .358 21. ,650 1.00 39. ,48 A N

ATOM 244 CA SER A 32 -37. 194 23. .562 21. ,330 1.00 40. ,05 A c

ATOM 246 CB SER A 32 -38. 120 24, .764 21.159 1.00 31. ,57 A c

ATOM 249 OG SER A 32 -37. 381 25, .934 20. ,862 1.00 29. ,36 A 0

ATOM 251 C SER A 32 -36. 193 23, ,823 22. ,443 1.00 41.43 A c

ATOM 252 0 SER A 32 -36. 576 24, ,152 23. ,561 1.00 43. ,00 A 0

ATOM 254 N VAL A 33 -34. 910 23, .660 22. ,138 1.00 43. ,35 A N

ATOM 255 CA VAL A 33 -33. 866 24, .015 23. ,076 1.00 42. ,77 A c

ATOM 257 CB VAL A 33 -32. 538 23, ,246 22. ,786 1.00 35. ,75 A c human fD_Fab

ATOM 259 CGI VAL A 33 -31. 435 23. .711 23. ,718 1.00 31. ,25 A C

ATOM 263 CG2 VAL A 33 -32. 744 21. .747 22, ,890 1.00 28. ,01 A C

ATOM 267 C VAL A 33 -33. 690 25. .525 22. ,960 1.00 44. ,24 A C

ATOM 268 O VAL A 33 -33. 426 26. ,039 21. ,880 1.00 39. ,38 A 0

ATOM 270 N GLN A 34 -33. 873 26. ,235 24. .069 1.00 48. 29 A N

ATOM 271 CA GLN A 34 -33. 866 27. ,707 24. ,052 1.00 48. 04 A C

ATOM 273 CB GLN A 34 -35. 238 28. ,210 24. ,471 1.00 46. 22 A c

ATOM 276 CG GLN A 34 -36. 205 28, ,036 23. ,344 1.00 47. ,69 A c

ATOM 279 CD GLN A 34 -37. 624 28. ,395 23. ,668 1.00 45. ,26 A c

ATOM 280 OEl GLN A 34 -37. 929 29. ,018 24. ,697 1.00 49. ,92 A 0

ATOM 281 NE2 GLN A 34 -38. 514 28. ,029 22. ,759 1.00 39. ,72 A N

ATOM 284 C GLN A 34 -32. 763 28. 342 24. ,884 1.00 44. 83 A c

ATOM 285 0 GLN A 34 -32. 353 27. ,790 25. ,880 1.00 41. 00 A 0

ATOM 287 N LEU A 35 -32. 280 29. ,497 24. ,437 1.00 48. 27 A N

ATOM 288 CA LEU A 35 -31. 318 30. ,321 25, ,184 1.00 48. 03 A c

ATOM 290 CB LEU A 35 -29. 988 30. ,434 24. ,440 1.00 47. 03 A c

ATOM 293 CG LEU A 35 -28. 845 31. ,167 25. ,163 1.00 43. 76 A c

ATOM 295 CDl LEU A 35 -28. 311 30. ,330 26. ,316 1.00 37. ,77 A c

ATOM 299 CD2 LEU A 35 -27. 748 31. ,540 24. ,206 1.00 41. 57 A c

ATOM 303 C LEU A 35 -31. 935 31. ,714 25. ,381 1.00 51. 07 A c

ATOM 304 O LEU A 35 -32. 126 32. ,459 24. ,413 1.00 48. 89 A 0

ATOM 306 N ASN A 36 -32. 258 32. ,039 26. ,633 1.00 52. 49 A N

ATOM 307 CA ASN A 36 -32. 900 33. ,303 26. ,975 1.00 52. 72 A c

ATOM 309 CB ASN A 36 -31.951 34. 493 26. ,733 1.00 54. 20 A c

ATOM 312 CG ASN A 36 -30. 717 34. ,449 27. ,628 1.00 54. 49 A c

ATOM 313 ODl ASN A 36 -30. 816 34. 123 28. ,815 1.00 56. 03 A 0

ATOM 314 ND2 ASN A 36 -29. 550 34. ,764 27. ,061 1.00 50. ,10 A N

ATOM 317 C ASN A 36 -34. 222 33. ,492 26. ,231 1.00 53. 80 A c

ATOM 318 O ASN A 36 -34. 469 34. ,542 25. .634 1.00 52. ,37 A 0

ATOM 320 N GLY A 37 -35. 062 32. ,457 26. ,272 1.00 54. ,17 A N

ATOM 321 CA GLY A 37 -36. 386 32. ,496 25. ,659 1.00 52. 62 A c

ATOM 324 C GLY A 37 -36. 444 32. ,645 24. ,146 1.00 52. 32 A c

ATOM 325 O GLY A 37 -37. 482 33. ,006 23. 602 1.00 54. ,37 A 0

ATOM 327 N ALA A 38 -35. 338 32. 352 23. ,469 1.00 51. 70 A N

ATOM 328 CA ALA A 38 -35. 270 32. ,380 22. ,008 1.00 50. ,80 A c

ATOM 330 CB ALA A 38 -34. 264 33. 422 21.506 1.00 47. ,75 A c

ATOM 334 C ALA A 38 -34. 872 30. ,994 21. ,533 1.00 50. ,65 A c

ATOM 335 O ALA A 38 -33. 970 30. ,366 22. ,121 1.00 49. ,42 A 0

ATOM 337 N HIS A 39 -35. 543 30. ,511 20. ,484 1.00 47. 04 A N

ATOM 338 CA HIS A 39 -35. 213 29. ,201 19. ,908 1.00 45. 21 A c

ATOM 340 CB HIS A 39 -36. 096 28. ,844 18. ,708 1.00 40. ,19 A C

ATOM 343 CG HIS A 39 -35. 717 27. ,549 18. ,055 1.00 37. ,56 A C

ATOM 344 NDl HIS A 39 -34. 868 27. ,478 16. ,967 1.00 34. ,45 A N

ATOM 346 CEl HIS A 39 -34. 692 26. ,219 16. ,631 1.00 28. ,52 A C

ATOM 348 NE2 HIS A 39 -35. 408 25. ,467 17. ,446 1.00 29. ,74 A N

ATOM 350 CD2 HIS A 39 -36. 044 26. ,275 18. ,356 1.00 31. ,74 A C

ATOM 352 C HIS A 39 -33. 764 29. .164 19. ,468 1.00 41. ,95 A C

ATOM 353 O HIS A 39 -33. 334 29. ,995 18. ,693 1.00 42. ,12 A 0

ATOM 355 N LEU A 40 -33. 032 28. ,180 19. ,970 1.00 41. 52 A N

ATOM 356 CA LEU A 40 -31. 635 28. ,003 19. ,630 1.00 42. ,84 A C

ATOM 358 CB LEU A 40 -30. 805 27. ,935 20. ,909 1.00 42. ,42 A C

ATOM 361 CG LEU A 40 -29. 307 27. ,740 20. ,722 1.00 43. ,96 A c

ATOM 363 CDl LEU A 40 -28. 681 28. ,890 19. ,904 1.00 37. ,84 A c

ATOM 367 CD2 LEU A 40 -28. 670 27. ,569 22. .097 1.00 44, ,98 A c

ATOM 371 C LEU A 40 -31. 429 26. ,751 18. .788 1.00 40. ,59 A c

ATOM 372 O LEU A 40 -30. 793 26. ,808 17. ,750 1.00 37. ,72 A 0

ATOM 374 N CYS A 41 -31. 991 25. ,634 19. ,241 1.00 40. ,38 A N

ATOM 375 CA CYS A 41 -31. 834 24, ,350 18. ,583 1.00 41. ,71 A c

ATOM 377 CB CYS A 41 -30. 610 23. ,612 19. ,159 1.00 41. ,82 A c

ATOM 380 SG CYS A 41 -29. 063 24. ,158 18. ,427 1.00 42. ,74 A S

ATOM 382 C CYS A 41 -33. 051 23. ,440 18. ,713 1.00 39. 02 A c

ATOM 383 O CYS A 41 -33. 859 23. ,579 19. ,629 1.00 35. ,68 A 0

ATOM 385 N GLY A 42 -33. 131 22. ,484 17. ,793 1.00 36. ,94 A N

ATOM 386 CA GLY A 42 -34. 081 21. ,408 17. ,863 1.00 36. ,45 A c

ATOM 389 C GLY A 42 -33. 619 20. .395 18. ,887 1.00 36. ,38 A c

ATOM 390 O GLY A 42 -32. 480 20. ,446 19. ,340 1.00 36. ,71 A 0

ATOM 392 N GLY A 43 -34. 513 19. .483 19, .255 1.00 33. ,20 A N

ATOM 393 CA GLY A 43 -34. 254 18. ,499 20, .285 1.00 36. ,09 A c human fD_Fab

ATOM 396 C GLY A 43 -35. ,287 17. ,396 20. ,213 1.00 36. ,63 A C

ATOM 397 O GLY A 43 -36. ,344 17. ,551 19. ,610 1.00 32. 97 A 0

ATOM 399 N VAL A 44 -34. ,976 16. ,259 20. ,806 1.00 40. 42 A N

ATOM 400 CA VAL A 44 -35. ,892 15. ,105 20. ,750 1.00 42. 72 A C

ATOM 402 CB VAL A 44 -35. ,495 14. ,068 19. ,606 1.00 39. 04 A C

ATOM 404 CGI VAL A 44 -34. ,023 13. ,962 19. ,453 1.00 39. 48 A c

ATOM 408 CG2 VAL A 44 -36.132 12. ,711 19. ,815 1.00 35. 34 A c

ATOM 412 C VAL A 44 -36. 000 14. ,499 22. ,145 1.00 43. 25 A c

ATOM 413 O VAL A 44 -35. 018 14. ,038 22. ,722 1.00 45. 23 A 0

ATOM 415 N LEU A 45 -37. 198 14. ,575 22. ,707 1.00 44. 58 A N

ATOM 416 CA LEU A 45 -37. 507 13. ,898 23. ,958 1.00 44. 82 A c

ATOM 418 CB LEU A 45 -38. 933 14. ,236 24. ,415 1.00 43. 69 A c

ATOM 421 CG LEU A 45 -39. 359 13. 737 25. ,802 1.00 42. 46 A c

ATOM 423 CDl LEU A 45 -38. ,580 14. ,472 26. ,878 1.00 38. 40 A c

ATOM 427 CD2 LEU A 45 -40. ,877 13. ,878 26. .008 1.00 37. 65 A c

ATOM 431 C LEU A 45 -37. 357 12. 408 23. ,719 1.00 44. 01 A c

ATOM 432 O LEU A 45 -38. 074 11. 851 22. ,887 1.00 43. 59 A 0

ATOM 434 N VAL A 46 -36. 385 11. ,803 24. ,410 1.00 45. 83 A N

ATOM 435 CA VAL A 46 -36. 062 10. 365 24. .303 1.00 47. 83 A C

ATOM 437 CB VAL A 46 -34. 574 10. 140 23. 945 1.00 43. 57 A C

ATOM 439 CGI VAL A 46 -34. 271 10. 678 22. 546 1.00 38. 95 A C

ATOM 443 CG2 VAL A 46 -33. 643 10. 783 25. ,007 1.00 39. 82 A C

ATOM 447 C VAL A 46 -36. 377 9. 585 25. ,602 1.00 51. 60 A c

ATOM 448 O VAL A 46 -36. 467 8. 349 25. ,584 1.00 51. 26 A 0

ATOM 450 N ALA A 47 -36. 515 10. 310 26. ,715 1.00 52. 53 A N

ATOM 451 CA ALA A 47 -36. 984 9. 750 27. ,976 1.00 52. 07 A c

ATOM 453 CB ALA A 47 -35. 829 9. ,361 28. .868 1.00 50. 19 A c

ATOM 457 C ALA A 47 -37. 822 10. ,790 28. ,678 1.00 55. 24 A c

ATOM 458 O ALA A 47 -37. 864 11. ,958 28. ,276 1.00 53. 14 A 0

ATOM 460 N GLU A 48 -38. 448 10. ,359 29. ,765 1.00 58. 81 A N

ATOM 461 CA GLU A 48 -39. 405 11. ,181 30. ,496 1.00 57. 62 A c

ATOM 463 CB GLU A 48 -39. 915 10. 423 31.730 1.00 63. 17 A c

ATOM 466 CG GLU A 48 -41. 418 10. ,444 31. ,916 1.00 64. 56 A c

ATOM 469 CD GLU A 48 -41. 871 9. ,512 33. ,030 1.00 66. 08 A c

ATOM 470 OEl GLU A 48 -42. 875 9. ,827 33. ,700 1.00 73. 81 A 0

ATOM 471 OE2 GLU A 48 -41. 217 8. ,472 33. ,247 1.00 67. 99 A 0

ATOM 472 C GLU A 48 -38. 813 12. 516 30. ,922 1.00 53. 49 A c

ATOM 473 O GLU A 48 -39. 501 13. 528 30. ,867 1.00 49. 44 A 0

ATOM 475 N GLN A 49 -37. 550 12. 526 31. ,353 1.00 53. 31 A N

ATOM 476 CA GLN A 49 -36. 901 13. 786 31.748 1.00 53. 35 A c

ATOM 478 CB GLN A 49 -36. 767 13. ,858 33. ,280 1.00 55. 68 A c

ATOM 481 CG GLN A 49 -35. 428 13. ,614 33. ,919 1.00 57. 60 A c

ATOM 484 CD GLN A 49 -35. 511 13. ,710 35. ,437 1.00 56. 94 A c

ATOM 485 OEl GLN A 49 -35. 835 14. ,759 35. ,983 1.00 52. 76 A 0

ATOM 486 NE2 GLN A 49 -35. 201 12. ,612 36. ,119 1.00 60. 22 A N

ATOM 489 C GLN A 49 -35. 584 14. ,104 31.007 1.00 49. 48 A c

ATOM 490 O GLN A 49 -34. 787 14. ,937 31. ,457 1.00 44. 39 A 0

ATOM 492 N TRP A 50 -35. 413 13. ,500 29. ,831 1.00 49. 60 A N

ATOM 493 CA TRP A 50 -34. 195 13. ,651 29. ,029 1.00 49. 30 A c

ATOM 495 CB TRP A 50 -33. 371 12. ,351 29. ,065 1.00 49. 11 A c

ATOM 498 CG TRP A 50 -32. 660 12. ,136 30. ,351 1.00 49. 20 A c

ATOM 499 CDl TRP A 50 -33. 038 11. ,314 31. ,374 1.00 49. 40 A c

ATOM 501 NEl TRP A 50 -32. 119 11. ,387 32. ,401 1.00 48. 77 A N

ATOM 503 CE2 TRP A 50 -31. 134 12. ,269 32. .051 1.00 47. 80 A c

ATOM 504 CD2 TRP A 50 -31. 442 12. ,761 30. .766 1.00 48. 84 A c

ATOM 505 CE3 TRP A 50 -30. 577 13. ,686 30.174 1.00 49. 75 A c

ATOM 507 CZ3 TRP A 50 -29. 451 14. ,089 30. ,873 1.00 49. 05 A c

ATOM 509 CH2 TRP A 50 -29. 171 13. ,582 32. ,144 1.00 48. 58 A c

ATOM 511 CZ2 TRP A 50 -29. 999 12. ,675 32. .750 1.00 49. 34 A c

ATOM 513 C TRP A 50 -34. 481 13. ,991 27. .572 1.00 44. 84 A c

ATOM 514 O TRP A 50 -35. 190 13. ,254 26. ,886 1.00 42. 47 A 0

ATOM 516 N VAL A 51 -33. 885 15. ,081 27. .104 1.00 44. 57 A N

ATOM 517 CA VAL A 51 -33. 982 15. ,521 25. .711 1.00 45. 11 A c

ATOM 519 CB VAL A 51 -34. 472 16. ,996 25. ,667 1.00 42. 88 A c

ATOM 521 CGI VAL A 51 -34. 414 17. ,571 24. .281 1.00 43. 18 A c

ATOM 525 CG2 VAL A 51 -35. 875 17. ,090 26. .199 1.00 40. 11 A c

ATOM 529 C VAL A 51 -32. 629 15. ,398 24. .994 1.00 42. 35 A c

ATOM 530 O VAL A 51 -31. 612 15. .848 25, ,505 1.00 44. 80 A 0 human fD_Fab

ATOM 532 N LEU A 52 -32. ,616 14. 788 23. 816 1.00 40. 60 A N

ATOM 533 CA LEU A 52 -31. ,397 14. 687 23. 013 1.00 39. 36 A C

ATOM 535 CB LEU A 52 -31.346 13. 344 22. 296 1.00 39. 00 A C

ATOM 538 CG LEU A 52 -30. ,082 12. 972 21.517 1.00 36. 01 A C

ATOM 540 CDl LEU A 52 -28. ,846 12. 953 22. 385 1.00 34. 75 A c

ATOM 544 CD2 LEU A 52 -30. 323 11. 631 20. 891 1.00 32. 80 A c

ATOM 548 C LEU A 52 -31. ,312 15. 836 22. 000 1.00 39. 33 A c

ATOM 549 O LEU A 52 -32. 291 16. 176 21. 350 1.00 38. 01 A 0

ATOM 551 N SER A 53 -30. ,124 16. 436 21. 906 1.00 39. 08 A N

ATOM 552 CA SER A 53 -29. ,854 17. 548 21. 014 1.00 36. 57 A c

ATOM 554 CB SER A 53 -30. ,136 18. 880 21. 724 1.00 42. 58 A c

ATOM 557 OG SER A 53 -30. ,121 19. 979 20. 818 1.00 42. 01 A 0

ATOM 559 C SER A 53 -28. ,411 17. 468 20. 550 1.00 32. 71 A c

ATOM 560 O SER A 53 -27. ,778 16. 409 20. 629 1.00 29. 49 A 0

ATOM 562 N ALA A 54 -27. ,890 18. 566 20. 020 1.00 36. 03 A N

ATOM 563 CA ALA A 54 -26. ,501 18. 608 19. 525 1.00 36. 03 A c

ATOM 565 CB ALA A 54 -26. 465 19. 224 18. 150 1.00 23. 83 A c

ATOM 569 C ALA A 54 -25. 579 19. 376 20. 501 1.00 36. 47 A c

ATOM 570 O ALA A 54 -25. 979 20. 355 21.098 1.00 36. 17 A 0

ATOM 572 N ALA A 55 -24. 349 18. 914 20. 666 1.00 40. 15 A N

ATOM 573 CA ALA A 55 -23. ,430 19. 495 21. 658 1.00 42. 40 A c

ATOM 575 CB ALA A 55 -22. ,210 18. 587 21. 855 1.00 38. 47 A c

ATOM 579 C ALA A 55 -23. ,008 20. 941 21. 340 1.00 44. 10 A c

ATOM 580 O ALA A 55 -23. 022 21. 783 22. 228 1.00 47. 54 A 0

ATOM 582 N HIS A 56 -22. 686 21. 235 20. 082 1.00 47. 14 A N

ATOM 583 CA HIS A 56 -22. 329 22. 599 19. 680 1.00 52. 44 A c

ATOM 585 CB HIS A 56 -21. 739 22. 620 18. 265 1.00 56. 26 A c

ATOM 588 CG HIS A 56 -22. 682 22. 152 17. 195 1.00 64. 58 A c

ATOM 589 NDl HIS A 56 -23. 882 22. 773 16. 911 1.00 64. 70 A N

ATOM 591 CEl HIS A 56 -24. 481 22. 145 15. 915 1.00 62. 33 A c

ATOM 593 NE2 HIS A 56 -23. 714 21. 141 15. 536 1.00 65. 65 A N

ATOM 595 CD2 HIS A 56 -22. 573 21. 137 16. 306 1.00 68. 69 A C

ATOM 597 C HIS A 56 -23. 463 23. 639 19. 773 1.00 51.31 A c

ATOM 598 0 HIS A 56 -23. 229 24. 818 19. 575 1.00 46. 76 A 0

ATOM 600 N CYS A 57 -24. 678 23. ,195 20. 061 1.00 52. 43 A N

ATOM 601 CA CYS A 57 -25. ,786 24. 099 20. 347 1.00 57. 44 A c

ATOM 603 CB CYS A 57 -27. ,092 23. 303 20. 510 1.00 53. 60 A c

ATOM 606 SG CYS A 57 -27. 729 22. ,698 18. 903 1.00 51. 73 A S

ATOM 608 C CYS A 57 -25. 517 24. ,960 21. 574 1.00 59. 55 A c

ATOM 609 0 CYS A 57 -25. 983 26. 091 21. 647 1.00 59. 26 A 0

ATOM 611 N LEU A 58 -24. 730 24. 426 22. 506 1.00 63. 27 A N

ATOM 612 CA LEU A 58 -24. 419 25. 097 23. 767 1.00 66. 56 A c

ATOM 614 CB LEU A 58 -24. 371 24. 046 24. 882 1.00 63. 41 A c

ATOM 617 CG LEU A 58 -25. 622 23. 868 25. 744 1.00 61. 68 A c

ATOM 619 CDl LEU A 58 -26. 933 23. 957 24. 958 1.00 59. 97 A c

ATOM 623 CD2 LEU A 58 -25. 499 22. ,554 26. 476 1.00 63. 41 A c

ATOM 627 C LEU A 58 -23. 104 25. ,894 23. 779 1.00 70. 10 A c

ATOM 628 0 LEU A 58 -22. ,776 26. ,512 24. 784 1.00 69. 58 A 0

ATOM 630 N GLU A 59 -22. ,366 25. 901 22. 672 1.00 75. 37 A N

ATOM 631 CA GLU A 59 -20. ,968 26. 350 22. 701 1.00 79. 91 A c

ATOM 633 CB GLU A 59 -20. 252 25. 991 21.398 1.00 80. 87 A c

ATOM 636 CG GLU A 59 -19. 586 24. ,613 21. 476 1.00 81. 90 A c

ATOM 639 CD GLU A 59 -19. 022 24. ,146 20. 147 1.00 84. 53 A c

ATOM 640 OEl GLU A 59 -18. 605 25. 003 19. 333 1.00 88. 67 A 0

ATOM 641 OE2 GLU A 59 -18. 980 22. ,914 19. 922 1.00 86. 47 A 0

ATOM 642 C GLU A 59 -20. 728 27. ,820 23. 089 1.00 84. 65 A c

ATOM 643 0 GLU A 59 -19. 875 28. ,099 23. 937 1.00 86. 61 A 0

ATOM 645 N ASP A 60 -21. 464 28. ,749 22. 484 1.00 87. 58 A N

ATOM 646 CA ASP A 60 -21. ,329 30. ,179 22. ,811 1.00 87. 99 A C

ATOM 648 CB ASP A 60 -21. 093 31. ,005 21. ,528 1.00 91. 03 A c

ATOM 651 CG ASP A 60 -19. ,714 30. ,764 20. ,896 1.00 94. 18 A c

ATOM 652 ODl ASP A 60 -19. ,504 31. ,217 19. ,744 1.00 94. 34 A 0

ATOM 653 OD2 ASP A 60 -18. 841 30. ,137 21. ,541 1.00 94. 84 A 0

ATOM 654 C ASP A 60 -22. 564 30. ,702 23. 548 1.00 87. 56 A c

ATOM 655 0 ASP A 60 -23. 137 31. ,729 23. 186 1.00 86. 58 A 0

ATOM 657 N ALA A 61 -22. 968 29. ,993 24. ,591 1.00 87. 90 A N

ATOM 658 CA ALA A 61 -24. 199 30. ,307 25. 264 1.00 89. 04 A c

ATOM 660 CB ALA A 61 -25. 108 29. ,071 25. 196 1.00 85. 74 A c human fD_Fab

ATOM 664 C ALA A 61 -24. ,124 30. ,767 26. 718 1.00 91. ,59 A C

ATOM 665 O ALA A 61 -24. ,587 31.866 27. 045 1.00 90. ,91 A 0

ATOM 667 N ALA A 62 -23. ,444 30. ,002 27. 568 1.00 93. .98 A N

ATOM 668 CA ALA A 62 -22. 219 30. ,314 28. 269 1.00 94. ,24 A C

ATOM 670 CB ALA A 62 -21. ,244 31. ,136 27. 417 1.00 97. ,50 A C

ATOM 674 C ALA A 62 -22. 748 31. ,089 29. 499 1.00 93. ,42 A c

ATOM 675 O ALA A 62 -22. 978 30. ,506 30. ,563 1.00 92. ,45 A 0

ATOM 677 N ASP A 63 -23. ,003 32. ,382 29. 326 1.00 93, .69 A N

ATOM 678 CA ASP A 63 -23. ,594 33. ,214 30. ,369 1.00 93. ,16 A c

ATOM 680 CB ASP A 63 -22. ,784 34. ,512 30. 509 1.00 94. ,65 A c

ATOM 683 CG ASP A 63 -23. 049 35. ,240 31. 820 1.00 95. ,79 A c

ATOM 684 ODl ASP A 63 -23. 532 34. ,610 32. 792 1.00 96. ,26 A 0

ATOM 685 002 ASP A 63 -22. 756 36. ,453 31. 879 1.00 97, ,27 A 0

ATOM 686 C ASP A 63 -25. 046 33. ,505 29. 989 1.00 93. ,25 A c

ATOM 687 0 ASP A 63 -25. 410 34. ,651 29. 709 1.00 94. ,38 A 0

ATOM 689 N GLY A 64 -25. 867 32. ,453 29. 971 1.00 89. ,98 A N

ATOM 690 CA GLY A 64 -27. 250 32. ,554 29. 506 1.00 85. ,69 A c

ATOM 693 C GLY A 64 -28. 150 31.467 30. 053 1.00 81. ,18 A c

ATOM 694 0 GLY A 64 -27. 683 30. ,416 30. 480 1.00 81. ,14 A 0

ATOM 696 N LYS A 65 -29. 449 31.735 30. 025 1.00 77. ,40 A N

ATOM 697 CA LYS A 65 -30. 466 30. ,848 30. 578 1.00 77, ,00 A C

ATOM 699 CB LYS A 65 -31.673 31.693 31. Oil 1.00 74, ,84 A C

ATOM 702 CG LYS A 65 -32. 872 30. ,935 31.541 1.00 73. ,81 A c

ATOM 705 CD LYS A 65 -32. 679 30. ,481 32. 971 1.00 73. ,55 A c

ATOM 708 CE LYS A 65 -34. 000 30. ,031 33. 567 1.00 73. ,70 A c

ATOM 711 NZ LYS A 65 -33. 809 29. ,240 34. 796 1.00 73. 80 A N

ATOM 715 C LYS A 65 -30. 884 29. ,825 29. 523 1.00 75, ,89 A C

ATOM 716 0 LYS A 65 -31. 497 30. ,186 28. 519 1.00 76. ,73 A 0

ATOM 718 N VAL A 66 -30. 557 28, .555 29. 747 1.00 73. ,08 A N

ATOM 719 CA VAL A 66 -30. 919 27. .494 28. 809 1.00 70. ,42 A C

ATOM 721 CB VAL A 66 -29. 768 26. ,497 28. 601 1.00 69. ,04 A c

ATOM 723 CGI VAL A 66 -30. 226 25. ,340 27. 717 1.00 67. ,62 A c

ATOM 727 CG2 VAL A 66 -28. 557 27. ,202 27. 996 1.00 68. ,13 A c

ATOM 731 C VAL A 66 -32. 163 26. ,733 29. 277 1.00 68. ,79 A c

ATOM 732 0 VAL A 66 -32. 217 26, ,264 30. 416 1.00 69. ,32 A 0

ATOM 734 N GLN A 67 -33. ,152 26. ,615 28. 387 1.00 64. ,55 A N

ATOM 735 CA GLN A 67 -34. 418 25. ,935 28. 688 1.00 60. ,73 A c

ATOM 737 CB GLN A 67 -35. 502 26. ,975 29. 001 1.00 59. ,49 A c

ATOM 740 CG GLN A 67 -35. 207 27, ,831 30. ,240 1.00 57, .87 A c

ATOM 743 CD GLN A 67 -36. 147 28, .996 30. 392 1.00 55, .49 A c

ATOM 744 OEl GLN A 67 -36. 255 29, ,831 29. ,505 1.00 55, .41 A 0

ATOM 745 NE2 GLN A 67 -36. 820 29, .073 31. 528 1.00 51. .83 A N

ATOM 748 C GLN A 67 -34.861 25, ,034 27. 524 1.00 57. ,44 A c

ATOM 749 0 GLN A 67 -34. 425 25, .221 26. 392 1.00 55. ,07 A 0

ATOM 751 N VAL A 68 -35. 713 24, .049 27. 818 1.00 54. ,50 A N

ATOM 752 CA VAL A 68 -36. 329 23, .209 26. ,788 1.00 50. .89 A C

ATOM 754 CB VAL A 68 -35. 982 21, ,728 26. ,947 1.00 46. ,32 A c

ATOM 756 CGI VAL A 68 -36. 662 20. ,904 25. 860 1.00 39. .26 A c

ATOM 760 CG2 VAL A 68 -34. 469 21. .528 26. ,926 1.00 41, .90 A c

ATOM 764 C VAL A 68 -37. 850 23, .348 26. ,820 1.00 47, .97 A c

ATOM 765 0 VAL A 68 -38. 471 23, .187 27. ,863 1.00 46, ,91 A 0

ATOM 767 N LEU A 69 -38. 428 23, .629 25. ,657 1.00 44, .63 A N

ATOM 768 CA LEU A 69 -39. 850 23, .848 25. ,495 1.00 43, .86 A c

ATOM 770 CB LEU A 69 -40. 068 25, .101 24. ,646 1.00 38, .62 A c

ATOM 773 CG LEU A< 69 -41. 466 25, .362 24. ,093 1.00 40, .29 A c

ATOM 775 CDl LEU A 69 -42. 458 25, .781 25. ,204 1.00 34, .14 A c

ATOM 779 CD2 LEU A 69 -41.354 26, .401 23. ,024 1.00 37, .23 A c

ATOM 783 C LEU A 69 -40. 504 22, .640 24. ,825 1.00 44, .47 A c

ATOM 784 0 LEU A 69 -40. 247 22, .354 23. ,646 1.00 40, .25 A 0

ATOM 786 N LEU A 70 -41. ,354 21, .937 25. ,583 1.00 44, .62 A N

ATOM 787 CA LEU A 70 -42. 091 20 .776 25. ,067 1.00 44, .08 A c

ATOM 789 CB LEU A 70 -41. 995 19, .618 26. ,062 1.00 38, .78 A c

ATOM 792 CG LEU A 70 -40. 567 19, .132 26. 319 1.00 34, .71 A c

ATOM 794 CDl LEU A 70 -40. 536 17, .996 27. ,315 1.00 29, .91 A c

ATOM 798 CD2 LEU A 70 -39. 882 18, ,717 25. 034 1.00 31, .31 A c

ATOM 802 C LEU A 70 -43. 555 21.082 24. ,721 1.00 44, .42 A c

ATOM 803 0 LEU A 70 -44. 108 22, .096 25. ,137 1.00 43, .92 A 0

ATOM 805 N GLY A 71 -44. 165 20, .198 23. ,937 1.00 45, .02 A N human fD_Fab

ATOM 806 CA GLY A 71 -45. 559 20, ,324 23. 528 1.00 43. ,62 A C

ATOM 809 C GLY A 71 -45. 862 21. ,520 22. 648 1.00 47. 34 A C

ATOM 810 O GLY A 71 -47. 022 21. ,903 22. 489 1.00 52. 44 A 0

ATOM 812 N ALA A 72 -44. 831 22. ,108 22. 049 1.00 49. 11 A N

ATOM 813 CA ALA A 72 -44. 988 23. ,336 21. 272 1.00 45. ,52 A C

ATOM 815 CB ALA A 72 -43. 758 24. ,230 21.420 1.00 39. ,29 A C

ATOM 819 C ALA A 72 -45. 272 23. ,073 19. 805 1.00 43. ,41 A C

ATOM 820 O ALA A 72 -44. 832 22. ,078 19. 220 1.00 43. 05 A 0

ATOM 822 N HIS A 73 -46. 059 23. ,966 19. 233 1.00 42. 28 A N

ATOM 823 CA HIS A 73 -46. 167 24. .066 17. 804 1.00 44. 42 A c

ATOM 825 CB HIS A 73 -47. 577 23. ,747 17. 308 1.00 39. 78 A c

ATOM 828 CG HIS A 73 -47. 652 23. ,711 15. 827 1.00 37. 63 A c

ATOM 829 NDl HIS A 73 -46. 907 22. ,820 15. 083 1.00 30. 51 A N

ATOM 831 CEl HIS A 73 -47. 115 23. ,050 13. 800 1.00 34. ,73 A c

ATOM 833 NE2 HIS A 73 -47. 951 24. ,072 13. 687 1.00 36. 61 A N

ATOM 835 CD2 HIS A 73 -48. 290 24. ,513 14. 943 1.00 33. 73 A c

ATOM 837 C HIS A 73 -45. 713 25. ,463 17. 361 1.00 44. 62 A c

ATOM 838 O HIS A 73 -44. 775 25. ,598 16. 586 1.00 41. 55 A 0

ATOM 840 N SER A 74 -46. 375 26. ,484 17. 885 1.00 44. 17 A N

ATOM 841 CA SER A 74 -45. 973 27. ,865 17. 705 1.00 42. 74 A c

ATOM 843 CB SER A 74 -47. 220 28. .768 17. 730 1.00 35. ,44 A c

ATOM 846 OG SER A 74 -46. ,881 30. ,124 17. 890 1.00 28. ,22 A 0

ATOM 848 C SER A 74 -45. 022 28. .236 18. 834 1.00 43. 01 A c

ATOM 849 0 SER A 74 -45. 258 27. ,867 19. 989 1.00 43. 03 A 0

ATOM 851 N LEU A 75 -43. 967 28. ,978 18. 507 1.00 44. 74 A N

ATOM 852 CA LEU A 75 -43. 016 29. ,469 19. 507 1.00 44. 88 A c

ATOM 854 CB LEU A 75 -41.698 29. ,850 18. 849 1.00 38. 49 A c

ATOM 857 CG LEU A 75 -40. 810 28. ,738 18. 253 1.00 37. 58 A c

ATOM 859 CDl LEU A 75 -39. 622 29. ,364 17. 525 1.00 28. 33 A c

ATOM 863 CD2 LEU A 75 -40. 317 27. ,775 19. 307 1.00 35. ,54 A c

ATOM 867 C LEU A 75 -43. 541 30. ,657 20. 333 1.00 46. ,25 A c

ATOM 868 O LEU A 75 -43. 256 30. ,756 21. 518 1.00 47. ,28 A 0

ATOM 870 N SER A 76 -44. 303 31. ,544 19. 707 1.00 46. 88 A N

ATOM 871 CA SER A 76 -44. 769 32. ,785 20. 351 1.00 47. 46 A c

ATOM 873 CB SER A 76 -44. 858 33. ,901 19. 299 1.00 42. 75 A c

ATOM 876 OG SER A 76 -45. 734 33. ,533 18. 244 1.00 37. 58 A 0

ATOM 878 C SER A 76 -46. 133 32. ,642 21. 033 1.00 48. 96 A c

ATOM 879 O SER A 76 -46. 403 33. ,232 22. 066 1.00 45. ,90 A 0

ATOM 881 N GLN A 77 -46. 985 31. ,838 20. 435 1.00 52. ,47 A N

ATOM 882 CA GLN A 77 -48. 370 31. ,829 20. 775 1.00 52. ,99 A c

ATOM 884 CB GLN A 77 -49. 161 31.545 19. 496 1.00 50. ,44 A c

ATOM 887 CG GLN A 77 -50. 307 32. ,494 19. 247 1.00 52. ,43 A c

ATOM 890 CD GLN A 77 -49. 938 33. ,977 19. 110 1.00 43. 39 A c

ATOM 891 OEl GLN A 77 -50. 817 34. ,803 19. 197 1.00 46. ,93 A 0

ATOM 892 NE2 GLN A 77 -48. 685 34. ,303 18. 866 1.00 38. 22 A N

ATOM 895 C GLN A 77 -48. 641 30. ,820 21. 895 1.00 53. 68 A c

ATOM 896 0 GLN A 77 -48. 027 29. .762 21. ,954 1.00 50. ,24 A 0

ATOM 898 N PRO A 78 -49. 518 31. .178 22. ,832 1.00 56. ,35 A N

ATOM 899 CA PRO A 78 -49. 900 30. .237 23. 878 1.00 56. 68 A c

ATOM 901 CB PRO A 78 -50. 726 31.081 24. 845 1.00 58. ,93 A c

ATOM 904 CG PRO A 78 -51. 064 32. ,332 24. 124 1.00 58. 68 A c

ATOM 907 CD PRO A 78 -50. 127 32. ,506 23. 002 1.00 59. 14 A c

ATOM 910 C PRO A 78 -50. 705 29, ,030 23. 377 1.00 55. ,02 A c

ATOM 911 0 PRO A 78 -51. 595 29. ,157 22. 534 1.00 49. ,94 A 0

ATOM 912 N GLU A 79 -50. 353 27, .868 23. ,913 1.00 54. ,95 A N

ATOM 913 CA GLU A 79 -50. 984 26. .604 23. ,590 1.00 54. ,27 A c

ATOM 915 CB GLU A 79 -50. 142 25. .814 22. ,568 1.00 51. ,71 A c

ATOM 918 CG GLU A 79 -49. 681 26. ,625 21. 332 1.00 50. ,40 A c

ATOM 921 CD GLU A 79 -48. 786 25. ,855 20. 352 1.00 45. 25 A c

ATOM 922 OEl GLU A 79 -47. 922 25. ,065 20. ,766 1.00 38. ,25 A 0

ATOM 923 OE2 GLU A 79 -48. 936 26. ,056 19. ,139 1.00 40. ,53 A 0

ATOM 924 C GLU A 79 -51. 096 25. ,824 24. 909 1.00 56. ,29 A c

ATOM 925 0 GLU A 79 -50. 222 25, .951 25. ,774 1.00 55. ,03 A 0

ATOM 927 N PRO A 80 -52. 183 25, .043 25. ,087 1.00 56. ,19 A N

ATOM 928 CA PRO A 80 -52. 372 24. .243 26. ,301 1.00 55. .24 A c

ATOM 930 CB PRO A 80 -53. 652 23. .449 26. ,006 1.00 54. ,28 A c

ATOM 933 CG PRO A 80 -54. 334 24, ,168 24. ,959 1.00 54. ,93 A c

ATOM 936 CD PRO A 80 -53. 322 24. .919 24. ,169 1.00 54. ,25 A c human fD_Fab

ATOM 939 C PRO A 80 -51. ,229 23. 278 26. 633 1. 00 54. ,96 A C

ATOM 940 O PRO A 80 -50. 820 23. 190 27. 786 1. 00 53. ,15 A 0

ATOM 941 N SER A 81 -50. 737 22. 563 25. 623 1. 00 55. ,26 A N

ATOM 942 CA SER A 81 -49. ,655 21. 592 25. 780 1. 00 51. ,82 A C

ATOM 944 CB SER A 81 -49. 595 20. 664 24. 553 1. 00 50. 54 A c

ATOM 947 OG SER A 81 -49. 942 21. 340 23. 352 1. 00 49. 55 A 0

ATOM 949 C SER A 81 -48. 285 22. 233 26. 029 1. 00 50. 14 A c

ATOM 950 O SER A 81 -47. 405 21. 582 26. 612 1. 00 47. 88 A 0

ATOM 952 N LYS A 82 -48. 109 23. 485 25. 585 1. 00 48. 50 A N

ATOM 953 CA LYS A 82 -46. 808 24. 188 25. 684 1. 00 48. 16 A c

ATOM 955 CB LYS A 82 -46. 830 25. 562 25. 012 1. 00 41. ,35 A c

ATOM 958 CG LYS A 82 -46. 465 25. 548 23. 568 1. 00 42. 18 A c

ATOM 961 CD LYS A 82 -46. 548 26. 940 22. 955 1. 00 46.02 A c

ATOM 964 CE LYS A 82 -45. 411 27. 833 23. 426 1. 00 41. 99 A c

ATOM 967 NZ LYS A 82 -45. 307 29. 063 22. 614 1. 00 39. 02 A N

ATOM 971 C LYS A 82 -46. 350 24. 394 27. 110 1. 00 50. 36 A c

ATOM 972 O LYS A 82 -47. 001 25. 103 27. 882 1. 00 56. 38 A 0

ATOM 974 N ARG A 83 -45. 215 23. 800 27. 454 1. 00 51. 83 A N

ATOM 975 CA ARG A 83 -44. 576 24. 071 28. 729 1. 00 51. 29 A c

ATOM 977 CB ARG A 83 -44. 894 22. 946 29. 713 1. 00 51. 99 A c

ATOM 980 CG ARG A 83 -44. 110 23. 062 30. 975 1. 00 52. 47 A c

ATOM 983 CD ARG A 83 -44. 618 22. 197 32. 099 1. 00 57. 04 A c

ATOM 986 NE ARG A 83 -43. 841 22. 508 33. 301 1. 00 59. 95 A N

ATOM 988 CZ ARG A 83 -43. 696 21. 721 34. 361 1. 00 60. 16 A c

ATOM 989 NHl ARG A 83 -44. 275 20. 527 34. 417 1. 00 59. 71 A N

ATOM 992 NH2 ARG A 83 -42. 944 22. 143 35. 371 1. 00 60. 89 A N

ATOM 995 C ARG A 83 -43. 050 24. 262 28. 589 1. 00 50. 71 A c

ATOM 996 0 ARG A 83 -42. 356 23. 425 28. 013 1. 00 46. 65 A 0

ATOM 998 N LEU A 84 -42. 547 25. 355 29. 159 1. 00 49. 98 A N

ATOM 999 CA LEU A 84 -41. 115 25. 680 29. 170 1. 00 51. 00 A C

ATOM 1001 CB LEU A 84 -40. 915 27. 201 29. 114 1. 00 45. 27 A C

ATOM 1004 CG LEU A 84 -39. 498 27. 686 28. 816 1. 00 46. 86 A C

ATOM 1006 CDl LEU A 84 -38. 976 27. 174 27. 436 1. 00 39. 33 A C

ATOM 1010 CD2 LEU A 84 -39. 410 29. 225 28. 915 1. 00 46. 81 A C

ATOM 1014 C LEU A 84 -40. 435 25. 127 30. 430 1. 00 52. 69 A c

ATOM 1015 0 LEU A 84 -40. 804 25. 503 31. 545 1. 00 53. 06 A 0

ATOM 1017 N TYR A 85 -39. 450 24. 240 30. 244 1. 00 52. 45 A N

ATOM 1018 CA TYR A 85 -38. 778 23. 546 31. 347 1. 00 53. 03 A c

ATOM 1020 CB TYR A 85 -38. 645 22. 061 31. 060 1. 00 50. 16 A c

ATOM 1023 CG TYR A 85 -39. 917 21. 261 31.096 1. 00 49. 10 A c

ATOM 1024 CDl TYR A 85 -40. 335 20. 643 32. 272 1. 00 50. 34 A c

ATOM 1026 CEl TYR A 85 -41. 489 19. 874 32. 309 1. 00 51. 02 A c

ATOM 1028 CZ TYR A 85 -42. 237 19. 715 31. 156 1. 00 51. 94 A c

ATOM 1029 OH TYR A 85 -43. 390 18. 961 31.185 1. 00 50. 54 A 0

ATOM 1031 CE2 TYR A 85 -41.834 20. ,321 29. 968 1. 00 49. ,59 A c

ATOM 1033 CD2 TYR A 85 -40. 677 21. 080 29. 946 1. 00 47. 22 A c

ATOM 1035 C TYR A 85 -37. 373 24. 063 31. 531 1. 00 55. ,04 A c

ATOM 1036 0 TYR A 85 -36. 676 24. 288 30. 557 1. 00 57. ,40 A 0

ATOM 1038 N ASP A 86 -36. 954 24. 230 32. 782 1. 00 57. ,37 A N

ATOM 1039 CA ASP A 86 -35. 567 24. 578 33. 087 1. 00 58. ,20 A c

ATOM 1041 CB ASP A 86 -35. 454 25. 240 34. 472 1. 00 59. 98 A c

ATOM 1044 CG ASP A 86 -35. 954 26. 685 34. 486 1. 00 60. 45 A c

ATOM 1045 001 ASP A 86 -36. 590 27. 123 33. 511 1. 00 64. 49 A 0

ATOM 1046 002 ASP A 86 -35. 702 27. 397 35. 471 1. 00 56. 83 A 0

ATOM 1047 C ASP A 86 -34. 702 23. 312 33. 012 1. 00 56. 50 A c

ATOM 1048 0 ASP A 86 -35. 213 22. 186 33. 055 1. 00 52. ,17 A 0

ATOM 1050 N VAL A 87 -33. 393 23. 496 32. 896 1. 00 54. ,74 A N

ATOM 1051 CA VAL A 87 -32. 490 22. ,358 32. 733 1. 00 58. ,06 A c

ATOM 1053 CB VAL A 87 -31.546 22. 519 31. 529 1. 00 53. ,55 A c

ATOM 1055 CGI VAL A 87 -30. 516 21. ,393 31. 521 1. 00 47. ,35 A c

ATOM 1059 CG2 VAL A 87 -32. 354 22. ,540 30. 231 1. 00 52. ,14 A c

ATOM 1063 C VAL A 87 -31. 662 22. ,104 33. 987 1. 00 59. ,51 A c

ATOM 1064 0 VAL A 87 -30. 884 22. ,961 34. 425 1. 00 59. ,01 A 0

ATOM 1066 N LEU A 88 -31. 838 20. ,906 34. 541 1. 00 61. ,78 A N

ATOM 1067 CA LEU A 88 -31. 117 20. 460 35. 733 1. 00 61. ,60 A c

ATOM 1069 CB LEU A 88 -31. 877 19. 298 36. 382 1. 00 62. 05 A c

ATOM 1072 CG LEU A 88 -31. 498 18. 852 37. 794 1. 00 65. 32 A c

ATOM 1074 CDl LEU A 88 -30. 978 20. ,006 38. ,662 1. 00 67. ,56 A c human fD_Fab

ATOM 1078 CD2 LEU A 88 -32. 701 18. 183 38. 441 1.00 61. ,41 A C

ATOM 1082 C LEU A 88 -29. 680 20. 041 35. 434 1.00 60. 99 A C

ATOM 1083 O LEU A 88 -28. 799 20. ,251 36. 257 1.00 61. ,07 A 0

ATOM 1085 N ARG A 89 -29. 442 19. ,476 34. 250 1.00 62. ,49 A N

ATOM 1086 CA ARG A 89 -28. 119 18. ,958 33. ,886 1.00 61. ,65 A C

ATOM 1088 CB ARG A 89 -27. 936 17. 562 34. ,496 1.00 65. ,13 A C

ATOM 1091 CG ARG A 89 -26. 589 17. 331 35. 170 1.00 65. ,72 A c

ATOM 1094 CD ARG A 89 -26. 562 15. 956 35. ,847 1.00 66. ,04 A c

ATOM 1097 NE ARG A 89 -25. 785 14. 958 35. 096 1.00 64. 91 A N

ATOM 1099 CZ ARG A 89 -26. 120 13. 673 34. 957 1.00 63. 00 A c

ATOM 1100 NHl ARG A 89 -27. 244 13. ,187 35. ,485 1.00 61.74 A N

ATOM 1103 NH2 ARG A 89 -25. 333 12. ,865 34. 259 1.00 63. ,34 A N

ATOM 1106 C ARG A 89 -27. 912 18. ,900 32. ,363 1.00 58. ,80 A c

ATOM 1107 0 ARG A 89 -28. 788 18. ,448 31. 625 1.00 56. ,35 A 0

ATOM 1109 N ALA A 90 -26. 747 19. ,366 31. ,912 1.00 57. ,44 A N

ATOM 1110 CA ALA A 90 -26. 350 19. ,318 30. 504 1.00 55. 33 A C

ATOM 1112 CB ALA A 90 -25. 982 20. 711 30. 018 1.00 52. 30 A C

ATOM 1116 C ALA A 90 -25. 163 18. 369 30. 338 1.00 52. 63 A c

ATOM 1117 0 ALA A 90 -24. 048 18. ,664 30. 786 1.00 49. 28 A 0

ATOM 1119 N VAL A 91 -25. 413 17. ,225 29. ,700 1.00 52. ,92 A N

ATOM 1120 CA VAL A 91 -24. 392 16. ,191 29. ,503 1.00 51. ,45 A c

ATOM 1122 CB VAL A 91 -24. 874 14. 848 30. 073 1.00 48. ,97 A c

ATOM 1124 CGI VAL A 91 -23. 701 13. ,834 30. 151 1.00 46. ,78 A c

ATOM 1128 CG2 VAL A 91 -25. 511 15. 060 31.421 1.00 44. 51 A c

ATOM 1132 C VAL A 91 -24. 028 16. 020 28. 024 1.00 48. ,39 A c

ATOM 1133 0 VAL A 91 -24. 635 15. ,211 27. 323 1.00 48. ,05 A 0

ATOM 1135 N PRO A 92 -23. 032 16. ,777 27. 552 1.00 46. ,74 A N

ATOM 1136 CA PRO A 92 -22. 539 16. 583 26. ,185 1.00 48. 60 A C

ATOM 1138 CB PRO A 92 -21. 602 17. 778 25. 963 1.00 45. 28 A C

ATOM 1141 CG PRO A 92 -21. 208 18. 242 27. 323 1.00 47. 04 A c

ATOM 1144 CD PRO A 92 -22. 288 17. 820 28. 285 1.00 46. ,34 A c

ATOM 1147 C PRO A 92 -21. 772 15. 265 26. 081 1.00 50. 44 A c

ATOM 1148 0 PRO A 92 -21. 228 14. 788 27. 082 1.00 53. 21 A 0

ATOM 1149 N HIS A 93 -21. 720 14. ,672 24. 894 1.00 48. 09 A N

ATOM 1150 CA HIS A 93 -20. 878 13. ,511 24. ,721 1.00 47. ,01 A c

ATOM 1152 CB HIS A 93 -20. 876 13. ,014 23. 285 1.00 40. ,04 A c

ATOM 1155 CG HIS A 93 -20. 197 11. 696 23. 140 1.00 36. ,35 A c

ATOM 1156 NDl HIS A 93 -18. 825 11. ,571 23. 108 1.00 34. 84 A N

ATOM 1158 CEl HIS A 93 -18. 505 10. ,295 23. 014 1.00 35. ,27 A C

ATOM 1160 NE2 HIS A 93 -19. 621 9. ,585 23. 014 1.00 32. ,37 A N

ATOM 1162 CD2 HIS A 93 -20. 693 10. ,441 23. 085 1.00 32. ,60 A C

ATOM 1164 C HIS A 93 -19. 461 13. ,886 25. ,173 1.00 47. ,46 A C

ATOM 1165 0 HIS A 93 -18. 985 14. ,980 24. ,852 1.00 45. ,31 A 0

ATOM 1167 N PRO A 94 -18. 796 12. ,998 25. ,943 1.00 51. ,60 A N

ATOM 1168 CA PRO A 94 -17. 458 13. ,312 26. ,478 1.00 51.57 A c

ATOM 1170 CB PRO A 94 -17. 083 12. ,047 27. 259 1.00 53. 26 A c

ATOM 1173 CG PRO A 94 -18. 399 11. ,389 27. ,573 1.00 53. ,10 A c

ATOM 1176 CD PRO A 94 -19. 271 11. ,677 26. ,404 1.00 51. ,99 A c

ATOM 1179 C PRO A 94 -16. 380 13. ,657 25. ,446 1.00 50. ,93 A c

ATOM 1180 0 PRO A 94 -15. 507 14. ,477 25. ,729 1.00 52. ,14 A 0

ATOM 1181 N ASP A 95 -16. 455 13. ,069 24. 263 1.00 48. ,49 A N

ATOM 1182 CA ASP A 95 -15. 435 13. ,302 23. ,247 1.00 50. ,21 A c

ATOM 1184 CB ASP A 95 -15. 045 11. ,972 22. ,567 1.00 46. ,31 A c

ATOM 1187 CG ASP A 95 -14. 766 10. ,842 23. ,575 1.00 42. ,25 A c

ATOM 1188 ODl ASP A 95 -14. 303 11. ,114 24. ,711 1.00 39. ,48 A 0

ATOM 1189 002 ASP A 95 -15. 032 9. ,670 23. ,234 1.00 41. ,62 A 0

ATOM 1190 C ASP A 95 -15. 832 14, ,394 22. ,239 1.00 50. .82 A c

ATOM 1191 0 ASP A 95 -15. 048 14. .682 21.327 1.00 50, ,65 A 0

ATOM 1193 N SER A 96 -17. 012 15. ,004 22. 417 1.00 49. ,86 A N

ATOM 1194 CA SER A 96 -17. 427 16. ,150 21. 603 1.00 53. ,39 A c

ATOM 1196 CB SER A 96 -18. 913 16. ,462 21.797 1.00 48. ,70 A c

ATOM 1199 OG SER A 96 -19. 199 16. ,994 23. ,071 1.00 43. ,71 A 0

ATOM 1201 C SER A 96 -16. 610 17. ,384 21. ,955 1.00 55. ,21 A c

ATOM 1202 0 SER A 96 -16. 148 17. ,517 23. ,079 1.00 49. .99 A 0

ATOM 1204 N GLN A 97 -16. 457 18. ,293 20. ,996 1.00 60. .71 A N

ATOM 1205 CA GLN A 97 -15. 715 19. ,528 21. ,236 1.00 63. .82 A c

ATOM 1207 CB GLN A 97 -14. 278 19. ,234 21. ,696 1.00 63. ,50 A c

ATOM 1210 CG GLN A 97 -13. 409 18. ,550 20. ,692 1.00 64. .48 A c human fD _Fab

ATOM 1213 CD GLN A 97 -12. , 206 17. 961 21. 363 1.00 64. 66 A C

ATOM 1214 OEl GLN A 97 -11. , 264 18. , 672 21.702 1.00 68. 20 A 0

ATOM 1215 NE2 GLN A 97 -12. 242 16. , 661 21. 593 1.00 62. 84 A N

ATOM 1218 C GLN A 97 -15. 785 20. 486 20. 029 1.00 64. 82 A C

ATOM 1219 0 GLN A 97 -16. 191 20. 076 18. 940 1.00 66. 33 A 0

ATOM 1221 N PRO A 98 -15. , 450 21. , 775 20. 251 1.00 65. 47 A N

ATOM 1222 CA PRO A 98 -15. 643 22. , 885 19. 314 1.00 66. 88 A C

ATOM 1224 CB PRO A 98 -14. 855 24. , 014 19. 974 1.00 66. 08 A C

ATOM 1227 CG PRO A 98 -15. 040 23. , 752 21. 411 1.00 64. 43 A C

ATOM 1230 CD PRO A 98 -14. 910 22. , 277 21. 533 1.00 63. 33 A C

ATOM 1233 C PRO A 98 -15. 210 22. 740 17. 858 1.00 68. 94 A C

ATOM 1234 0 PRO A 98 -15. 904 23. , 279 16. 979 1.00 69. 94 A 0

ATOM 1235 N ASP A 99 -14. 095 22. 056 17. 599 1.00 67. 24 A N

ATOM 1236 CA ASP A 99 -13. 512 22. 050 16. 256 1.00 67. 21 A c

ATOM 1238 CB ASP A 99 -12. 071 22. , 553 16. 335 1.00 69. 13 A c

ATOM 1241 CG ASP A 99 -11. 989 23. , 989 16. 853 1.00 71.08 A c

ATOM 1242 ODl ASP A 99 -12. 087 24. , 915 16. 024 1.00 71. 97 A 0

ATOM 1243 OD2 ASP A 99 -11. , 870 24. , 200 18. 082 1.00 71.41 A 0

ATOM 1244 C ASP A 99 -13. 620 20. , 686 15. 570 1.00 65. 98 A c

ATOM 1245 0 ASP A 99 -12. 728 20. , 260 14. 832 1.00 64. 85 A 0

ATOM 1247 N THR A 100 -14. 744 20. ,020 15. 810 1.00 63. 79 A N

ATOM 1248 CA THR A 100 -15. 025 18. 719 15. 231 1.00 61. 72 A c

ATOM 1250 CB THR A 100 -14. 310 17. 602 16. 052 1.00 61. 83 A c

ATOM 1252 OGl THR A 100 -14. 781 16. 312 15. 644 1.00 63. 00 A 0

ATOM 1254 CG2 THR A 100 -14. 543 17. , 764 17. 539 1.00 58. 82 A c

ATOM 1258 C THR A 100 -16. 519 18. , 460 15. 202 1.00 58. 86 A c

ATOM 1259 0 THR A 100 -17. 205 18. , 735 16. 182 1.00 60. 59 A 0

ATOM 1261 N ILE A 101 -17. 022 17. , 948 14. 077 1.00 57. 50 A N

ATOM 1262 CA ILE A 101 -18. 430 17. , 538 13. 984 1.00 57. 02 A c

ATOM 1264 CB ILE A 101 -18. 925 17. , 525 12. 514 1.00 60. 93 A c

ATOM 1266 CGl ILE A 101 -18. 406 16. , 316 11. 732 1.00 58. 89 A c

ATOM 1269 CDl ILE A 101 -18. 912 16. , 299 10. 279 1.00 58. 06 A c

ATOM 1273 CG2 ILE A 101 -18. 502 18. 820 11. 819 1.00 68. 53 A c

ATOM 1277 C ILE A 101 -18. 666 16. , 177 14. 655 1.00 54. 01 A c

ATOM 1278 0 ILE A 101 -19. 791 15. , 709 14. 754 1.00 55. 00 A 0

ATOM 1280 N ASP A 102 -17. 591 15. 553 15. 121 1.00 53. 57 A N

ATOM 1281 CA ASP A 102 -17. 660 14. , 237 15. 754 1.00 50. 75 A c

ATOM 1283 CB ASP A 102 -16. 272 13. 641 16. 006 1.00 48. 38 A c

ATOM 1286 CG ASP A 102 -15. 548 13. 258 14. 754 1.00 48. 28 A c

ATOM 1287 ODl ASP A 102 -16. 192 12. 891 13. 743 1.00 45. 67 A 0

ATOM 1288 OD2 ASP A 102 -14. 304 13. 304 14. 810 1.00 49. 61 A 0

ATOM 1289 C ASP A 102 -18. 305 14. , 269 17. 117 1.00 48. 07 A c

ATOM 1290 0 ASP A 102 -18. 057 15. , 177 17. 912 1.00 45. ,92 A 0

ATOM 1292 N HIS A 103 -19. 090 13. , 229 17. 393 1.00 45. 69 A N

ATOM 1293 CA HIS A 103 -19. 711 13. ,005 18. 700 1.00 44. , 33 A c

ATOM 1295 CB HIS A 103 -18. 666 12. , 749 19. 794 1.00 38. , 79 A c

ATOM 1298 CG HIS A 103 -17. 506 11.915 19. 341 1.00 41. 56 A c

ATOM 1299 NDl HIS A 103 -17. 663 10. , 686 18. 742 1.00 37. , 73 A N

ATOM 1301 CEl HIS A 103 -16. 477 10. 193 18. 440 1.00 37. , 00 A c

ATOM 1303 NE2 HIS A 103 -15. 555 11. 057 18. 824 1.00 38. , 87 A N

ATOM 1305 CD2 HIS A 103 -16. 172 12. , 146 19. 386 1.00 38. ,48 A c

ATOM 1307 C HIS A 103 -20. 614 14. , 142 19. 125 1.00 43. , 13 A c

ATOM 1308 0 HIS A 103 -20. 715 14. , 447 20. , 315 1.00 40. , 05 A 0

ATOM 1310 N ASP A 104 -21. 319 14. , 725 18. 161 1.00 44. , 47 A N

ATOM 1311 CA ASP A 104 -22. 037 15. , 982 18. 375 1.00 42. , 56 A c

ATOM 1313 CB ASP A 104 -22. 089 16. , 747 17. 057 1.00 38. , 91 A c

ATOM 1316 CG ASP A 104 -22 . 582 18. , 136 17. 215 1.00 36. , 89 A c

ATOM 1317 ODl ASP A 104 -22. 577 18. , 681 18. 339 1.00 41. 50 A 0

ATOM 1318 OD2 ASP A 104 -22. 977 18. , 698 16. 196 1.00 34. 86 A 0

ATOM 1319 C ASP A 104 -23. 430 15. , 738 18. 942 1.00 42. , 65 A c

ATOM 1320 0 ASP A 104 -24. 429 16. , 114 18. 344 1.00 41. , 82 A 0

ATOM 1322 N LEU A 105 -23. 459 15. , 104 20. , 110 1.00 42. , 25 A N

ATOM 1323 CA LEU A 105 -24. 674 14. , 760 20. 804 1.00 43. , 97 A c

ATOM 1325 CB LEU A 105 -24. 851 13. , 233 20. 871 1.00 41. ,45 A c

ATOM 1328 CG LEU A 105 -25. 261 12. , 560 19. 555 1.00 36. , 84 A c

ATOM 1330 CDl LEU A 105 -25. 461 11. , 050 19. , 730 1.00 35. , 78 A c

ATOM 1334 CD2 LEU A 105 -26. 525 13. , 233 18. , 983 1.00 28. , 50 A c

ATOM 1338 C LEU A 105 -24. 657 15. , 375 22. 194 1.00 45. ,41 A c human fD_Fab

ATOM 1339 O LEU A 105 -23. 610 15. 503 22. ,807 1.00 47. 08 A 0

ATOM 1341 N LEU A 106 -25. 831 15. 787 22. 665 1.00 48. 88 A N

ATOM 1342 CA LEU A 106 -25. 983 16. 396 23. 993 1.00 48. 41 A C

ATOM 1344 CB LEU A 106 -25. 943 17. 925 23. 897 1.00 47. 38 A C

ATOM 1347 CG LEU A 106 -26. 502 18. 786 25. 040 1.00 45. 25 A C

ATOM 1349 CDl LEU A 106 -26. 838 20. 172 24. 532 1.00 43. 77 A C

ATOM 1353 CD2 LEU A 106 -25. ,554 18. 846 26. ,224 1.00 37. 10 A C

ATOM 1357 C LEU A 106 -27. 288 15. 910 24. 616 1.00 47. 50 A C

ATOM 1358 O LEU A 106 -28. 341 15. 970 23. 992 1.00 42. 37 A 0

ATOM 1360 N LEU A 107 -27. 199 15. 423 25. 848 1.00 48. 53 A N

ATOM 1361 CA LEU A 107 -28. 371 14. 980 26. 593 1.00 50. 23 A C

ATOM 1363 CB LEU A 107 -28. 121 13. 604 27. 202 1.00 44. 46 A c

ATOM 1366 CG LEU A 107 -28. 846 12. 393 26. 609 1.00 42. 22 A c

ATOM 1368 CDl LEU A 107 -27. ,865 11. 380 26. 021 1.00 38. 30 A c

ATOM 1372 CD2 LEU A 107 -29. ,947 12. 779 25. ,626 1.00 36. 02 A c

ATOM 1376 C LEU A 107 -28. 747 16. 000 27. 683 1.00 49. 80 A c

ATOM 1377 0 LEU A 107 -27. 947 16. 286 28. 552 1.00 50. 91 A 0

ATOM 1379 N LEU A 108 -29. 959 16. 551 27. 618 1.00 51.07 A N

ATOM 1380 CA LEU A 108 -30. 424 17. 538 28. 605 1.00 51. 31 A c

ATOM 1382 CB LEU A 108 -31. 114 18. 729 27. 930 1.00 49. 10 A c

ATOM 1385 CG LEU A 108 -30. 339 19. 782 27. 123 1.00 50. 36 A c

ATOM 1387 CDl LEU A 108 -29. ,133 20. 300 27. ,873 1.00 49. 79 A c

ATOM 1391 CD2 LEU A 108 -29. ,916 19. 224 25. ,783 1.00 56. 15 A c

ATOM 1395 C LEU A 108 -31. 392 16. 897 29. ,613 1.00 51. 75 A c

ATOM 1396 0 LEU A 108 -32. 364 16. 254 29. 227 1.00 47. 73 A 0

ATOM 1398 N GLN A 109 -31. 119 17. 070 30. 903 1.00 54. 09 A N

ATOM 1399 CA GLN A 109 -32. 020 16. 593 31. 942 1.00 55. 67 A c

ATOM 1401 CB GLN A 109 -31. 251 16. 115 33. 163 1.00 54. 72 A c

ATOM 1404 CG GLN A 109 -32. 126 15. 346 34. 143 1.00 53. 89 A c

ATOM 1407 CD GLN A 109 -31.391 14. 955 35. 398 1.00 54. 26 A c

ATOM 1408 OEl GLN A 109 -30. 578 15. 723 35. ,924 1.00 55. 12 A 0

ATOM 1409 NE2 GLN A 109 -31.676 13. 755 35. ,896 1.00 50. 54 A N

ATOM 1412 C GLN A 109 -32. 960 17. 715 32. ,351 1.00 57. 09 A c

ATOM 1413 O GLN A 109 -32. 516 18. 769 32. 798 1.00 55. 13 A 0

ATOM 1415 N LEU A 110 -34. 261 17. 479 32. 227 1.00 59. 10 A N

ATOM 1416 CA LEU A 110 -35. 246 18. 507 32. 566 1.00 61. 11 A c

ATOM 1418 CB LEU A 110 -36. 612 18. 196 31. 944 1.00 58. 48 A c

ATOM 1421 CG LEU A 110 -36. ,657 17. 967 30. ,430 1.00 53. 45 A c

ATOM 1423 CDl LEU A 110 -38. 055 17. 522 30. ,040 1.00 51. 44 A c

ATOM 1427 CD2 LEU A 110 -36. 223 19. 200 29. ,656 1.00 44. 58 A c

ATOM 1431 C LEU A 110 -35. 375 18. 667 34. 083 1.00 63. 27 A c

ATOM 1432 O LEU A 110 -34. 950 17. 791 34. 851 1.00 62. 43 A 0

ATOM 1434 N SER A 111 -35. 956 19. 796 34. 493 1.00 64. 47 A N

ATOM 1435 CA SER A 111 -36. 090 20. 162 35. ,916 1.00 63. 43 A c

ATOM 1437 CB SER A 111 -36. 803 21. 513 36. ,064 1.00 62. 75 A c

ATOM 1440 OG SER A 111 -38. ,073 21. 496 35. ,434 1.00 60. 81 A 0

ATOM 1442 C SER A 111 -36. ,821 19. 089 36. ,717 1.00 62. ,50 A c

ATOM 1443 O SER A 111 -36. 526 18. 877 37. ,885 1.00 63. ,11 A 0

ATOM 1445 N GLU A 112 -37. ,776 18. 434 36. ,064 1.00 61. ,33 A N

ATOM 1446 CA GLU A 112 -38. 462 17. 258 36. ,582 1.00 62. 10 A c

ATOM 1448 CB GLU A 112 -39. 701 17. 670 37. ,389 1.00 65. 45 A c

ATOM 1451 CG GLU A 112 -40. 651 18. 649 36. ,667 1.00 65. 19 A c

ATOM 1454 CD GLU A 112 -42. 020 18. 740 37. ,329 1.00 65. 68 A c

ATOM 1455 OEl GLU A 112 -42. ,264 19. 742 38. ,020 1.00 65. 89 A 0

ATOM 1456 OE2 GLU A 112 -42. ,851 17. 815 37. ,170 1.00 64. ,67 A 0

ATOM 1457 C GLU A 112 -38. 882 16. ,406 35. ,397 1.00 58. ,55 A c

ATOM 1458 O GLU A 112 -38. ,713 16. ,814 34. ,255 1.00 55. 38 A 0

ATOM 1460 N LYS A 113 -39. 453 15. 238 35. ,653 1.00 59. ,56 A N

ATOM 1461 CA LYS A 113 -40. Oil 14. 446 34. ,568 1.00 61. ,29 A C

ATOM 1463 CB LYS A 113 -40. 621 13. 126 35. ,069 1.00 64. ,67 A c

ATOM 1466 CG LYS A 113 -41. 792 13. 270 36. ,058 1.00 70. ,78 A c

ATOM 1469 CD LYS A 113 -42. ,799 12. 102 35. ,938 1.00 69. 24 A c

ATOM 1472 CE LYS A 113 -43. ,946 12. 236 36. ,923 1.00 68. ,35 A c

ATOM 1475 NZ LYS A 113 -44. 749 13. 459 36. ,646 1.00 71. ,97 A N

ATOM 1479 C LYS A 113 -41. 014 15. ,297 33. ,779 1.00 61. 27 A c

ATOM 1480 O LYS A 113 -41. 679 16. 174 34. ,330 1.00 61. 20 A 0

ATOM 1482 N ALA A 114 -41. 082 15. 057 32. ,473 1.00 61. ,55 A N

ATOM 1483 CA ALA A 114 -41. 948 15. 818 31.588 1.00 59. ,70 A c human fD_Fab

ATOM 1485 CB ALA A 114 -41. ,507 15. ,640 30. ,124 1.00 60. ,17 A C

ATOM 1489 C ALA A 114 -43. ,380 15. ,359 31. ,769 1.00 57. ,41 A C

ATOM 1490 O ALA A 114 -43. ,640 14. ,167 31.819 1.00 57. 49 A 0

ATOM 1492 N THR A 115 -44. 300 16. ,313 31. ,869 1.00 56. 47 A N

ATOM 1493 CA THR A 115 -45. 721 16. ,013 31.906 1.00 57. 10 A c

ATOM 1495 CB THR A 115 -46. 565 17. ,245 32. 281 1.00 51.25 A c

ATOM 1497 OG1 THR A 115 -45. 964 17. ,909 33. ,395 1.00 47. ,12 A 0

ATOM 1499 CG2 THR A 115 -47. 978 16. ,828 32. ,642 1.00 48. ,71 A c

ATOM 1503 C THR A 115 -46. 136 15. 462 30. ,536 1.00 59. ,04 A c

ATOM 1504 O THR A 115 -46. 222 16. ,198 29. ,542 1.00 58. 19 A 0

ATOM 1506 N LEU A 116 -46. 373 14. 152 30. ,499 1.00 58. 77 A N

ATOM 1507 CA LEU A 116 -46. 709 13. 460 29. 266 1.00 57. 56 A c

ATOM 1509 CB LEU A 116 -46. 307 11. 982 29. ,345 1.00 55. 60 A c

ATOM 1512 CG LEU A 116 -44. 819 11. 729 29. ,658 1.00 54. 47 A c

ATOM 1514 CDl LEU A 116 -44. 496 10. ,248 29. 704 1.00 53. 55 A c

ATOM 1518 CD2 LEU A 116 -43. 887 12. 430 28. 669 1.00 55. 55 A c

ATOM 1522 C LEU A 116 -48. 184 13. ,647 28. 941 1.00 56. 26 A c

ATOM 1523 O LEU A 116 -48. 984 13. 983 29. ,811 1.00 57. ,31 A 0

ATOM 1525 N GLY A 117 -48. 526 13. ,466 27. ,669 1.00 57. 80 A N

ATOM 1526 CA GLY A 117 -49. 882 13. ,720 27. ,179 1.00 58. 66 A c

ATOM 1529 C GLY A 117 -49. 952 13. ,417 25. ,701 1.00 60. 57 A c

ATOM 1530 O GLY A 117 -49. 035 12. ,787 25. 169 1.00 62. 21 A 0

ATOM 1532 N PRO A 118 -51. 037 13. ,841 25. 025 1.00 60. 43 A N

ATOM 1533 CA PRO A 118 -51. 149 13. ,603 23. ,578 1.00 60. 56 A c

ATOM 1535 CB PRO A 118 -52. 591 14. ,038 23. 249 1.00 61. 74 A c

ATOM 1538 CG PRO A 118 -52. 999 14. 930 24. 344 1.00 62. 45 A c

ATOM 1541 CD PRO A 118 -52. 224 14. ,519 25. 569 1.00 61.71 A c

ATOM 1544 C PRO A 118 -50. 122 14. 372 22. 732 1.00 59. 24 A c

ATOM 1545 O PRO A 118 -49. 739 13. ,899 21. 660 1.00 55. 41 A 0

ATOM 1546 N ALA A 119 -49. 683 15. ,530 23. 236 1.00 60. 29 A N

ATOM 1547 CA ALA A 119 -48. 747 16. ,425 22 . ,545 1.00 57. 02 A c

ATOM 1549 CB ALA A 119 -49. 257 17. ,846 22. 657 1.00 52. 94 A c

ATOM 1553 C ALA A 119 -47. 303 16. ,369 23. 061 1.00 54. 79 A c

ATOM 1554 O ALA A 119 -46. 443 17. ,063 22. 523 1.00 57. 26 A 0

ATOM 1556 N VAL A 120 -47. 040 15. ,567 24. ,093 1.00 52. 53 A N

ATOM 1557 CA VAL A 120 -45. 704 15. ,456 24. ,690 1.00 54. 80 A c

ATOM 1559 CB VAL A 120 -45. 545 16. 342 25. ,961 1.00 48. 73 A c

ATOM 1561 CGl VAL A 120 -44. 154 16. ,209 26. 543 1.00 42. 03 A c

ATOM 1565 CG2 VAL A 120 -45. 844 17. ,814 25. ,653 1.00 40. 56 A c

ATOM 1569 C VAL A 120 -45. 391 13. ,996 25. ,039 1.00 57. 52 A c

ATOM 1570 O VAL A 120 -46. 034 13. ,414 25. ,903 1.00 59. 64 A 0

ATOM 1572 N ARG A 121 -44. 379 13. ,426 24. ,383 1.00 61. 52 A N

ATOM 1573 CA ARG A 121 -44. 082 11.989 24. ,471 1.00 62. 26 A c

ATOM 1575 CB ARG A 121 -45. 138 11. ,187 23. ,685 1.00 66. 21 A c

ATOM 1578 CG ARG A 121 -44. 864 9. ,681 23. ,609 1.00 69. 04 A c

ATOM 1581 CD ARG A 121 -45. 949 8. ,917 22 . ,841 1.00 72. 08 A c

ATOM 1584 NE ARG A 121 -46. 104 7. ,529 23. ,305 1.00 74. 39 A N

ATOM 1586 cz ARG A 121 -47. 041 6. ,675 22 . ,874 1.00 76. 63 A c

ATOM 1587 NHl ARG A 121 -47. 924 7. ,051 21. ,948 1.00 79. 00 A N

ATOM 1590 NH2 ARG A 121 -47. 093 5. ,432 23. ,369 1.00 75. 83 A N

ATOM 1593 C ARG A 121 -42. 676 11. ,646 23. ,937 1.00 60. 65 A c

ATOM 1594 O ARG A 121 -42. 285 12. ,142 22. .896 1.00 59. ,40 A 0

ATOM 1596 N PRO A 122 -41. 908 10. ,804 24. ,656 1.00 60. ,04 A N

ATOM 1597 CA PRO A 122 -40. 622 10. , 333 24. ,116 1.00 57. 74 A c

ATOM 1599 CB PRO A 122 -40. 052 9. ,454 25. ,233 1.00 57. 79 A c

ATOM 1602 CG PRO A 122 -41. 139 9. ,263 26. ,226 1.00 60. 27 A c

ATOM 1605 CD PRO A 122 -42. 157 10. ,323 26. ,029 1.00 60. 02 A c

ATOM 1608 C PRO A 122 -40. 685 9. ,554 22. ,784 1.00 55. 16 A c

ATOM 1609 O PRO A 122 -41.685 8. ,901 22. ,482 1.00 53. 39 A 0

ATOM 1610 N LEU A 123 -39. 609 9. ,652 22. ,006 1.00 53. 22 A N

ATOM 1611 CA LEU A 123 -39. 451 8. ,912 20. ,745 1.00 55. 04 A c

ATOM 1613 CB LEU A 123 -38. 957 9. ,843 19. ,623 1.00 55. 08 A c

ATOM 1616 CG LEU A 123 -38. 636 9. ,292 18. ,217 1.00 52. ,47 A c

ATOM 1618 CDl LEU A 123 -37. 967 10. ,359 17. ,363 1.00 48. 36 A c

ATOM 1622 CD2 LEU A 123 -39. 870 8. ,734 17, ,504 1.00 50. ,77 A c

ATOM 1626 C LEU A 123 -38. 460 7. ,757 20. ,939 1.00 54. 62 A c

ATOM 1627 O LEU A 123 -37. 383 7. ,941 21. ,515 1.00 56. 24 A 0

ATOM 1629 N PRO A 124 -38. 835 6. ,556 20. ,483 1.00 53. 12 A N human fD_Fab

ATOM 1630 CA PRO A 124 -37. ,894 5. 449 20. 430 1.00 53. 52 A C

ATOM 1632 CB PRO A 124 -38. 722 4. 301 19. 829 1.00 55. 20 A C

ATOM 1635 CG PRO A 124 -40. ,119 4. 693 19. 972 1.00 57. 41 A c

ATOM 1638 CD PRO A 124 -40. ,172 6. 174 20. 007 1.00 55. 78 A C

ATOM 1641 C PRO A 124 -36. 735 5. 770 19. 492 1.00 50. 75 A C

ATOM 1642 O PRO A 124 -36. ,953 6. 320 18. 414 1.00 45. 27 A 0

ATOM 1643 N TRP A 125 -35. 522 5. 414 19. 883 1.00 49. 34 A N

ATOM 1644 CA TRP A 125 -34. 367 5. 701 19. 048 1.00 49. 97 A C

ATOM 1646 CB TRP A 125 -33. 424 6. 687 19. 759 1.00 45. 53 A c

ATOM 1649 CG TRP A 125 -32. 992 6. 244 21. 122 1.00 46. 06 A c

ATOM 1650 CDl TRP A 125 -33. 628 6. 475 22. 319 1.00 45. 03 A c

ATOM 1652 NEl TRP A 125 -32. ,910 5. 910 23. 352 1.00 43. 44 A N

ATOM 1654 CE2 TRP A 125 -31. ,813 5. 275 22. 825 1.00 45. 17 A c

ATOM 1655 CD2 TRP A 125 -31. ,831 5. 475 21. 428 1.00 45. 03 A c

ATOM 1656 CE3 TRP A 125 -30. ,798 4. 941 20. 654 1.00 44. 01 A c

ATOM 1658 CZ3 TRP A 125 -29. 803 4. 235 21.275 1.00 44. 32 A c

ATOM 1660 CH2 TRP A 125 -29. 806 4. 052 22. 667 1.00 44. 85 A c

ATOM 1662 CZ2 TRP A 125 -30. 799 4. 565 23. 456 1.00 45. 17 A c

ATOM 1664 C TRP A 125 -33. 693 4. 402 18. 614 1.00 48. 38 A c

ATOM 1665 O TRP A 125 -33. 809 3. 386 19. 278 1.00 51. 66 A 0

ATOM 1667 N GLN A 126 -33. ,029 4. 434 17. ,470 1.00 48. 01 A N

ATOM 1668 CA GLN A 126 -32. ,471 3. 223 16. ,870 1.00 50. 83 A c

ATOM 1670 CB GLN A 126 -32. 067 3. 472 15. 407 1.00 43. 96 A c

ATOM 1673 CG GLN A 126 -31.632 2. 226 14. 643 1.00 45. 69 A c

ATOM 1676 CD GLN A 126 -32. 710 1. 132 14. 581 1.00 44. 47 A c

ATOM 1677 OEl GLN A 126 -32. 695 0. 199 15. 370 1.00 43. 95 A 0

ATOM 1678 NE2 GLN A 126 -33. 636 1. 253 13. 641 1.00 45. 14 A N

ATOM 1681 C GLN A 126 -31. 294 2. 657 17. 687 1.00 50. 87 A c

ATOM 1682 O GLN A 126 -30. 306 3. 341 17. 950 1.00 47. 87 A 0

ATOM 1684 N ARG A 127 -31. ,425 1. 396 18. ,079 1.00 54. 20 A N

ATOM 1685 CA ARG A 127 -30. 458 0. 737 18. ,943 1.00 56. 29 A c

ATOM 1687 CB ARG A 127 -31. 210 -0. 075 19. ,996 1.00 59. 81 A c

ATOM 1690 CG ARG A 127 -30. 376 -0. 441 21.206 1.00 61. 36 A c

ATOM 1693 CD ARG A 127 -31. 242 -1. 083 22. 264 1.00 59. 55 A c

ATOM 1696 NE ARG A 127 -32. 100 -0. 089 22. 892 1.00 59. 79 A N

ATOM 1698 cz ARG A 127 -31. 709 0. 742 23. 854 1.00 60. 46 A c

ATOM 1699 NHl ARG A 127 -30. 460 0. 703 24. 313 1.00 57. 51 A N

ATOM 1702 NH2 ARG A 127 -32. ,577 1. 614 24. ,368 1.00 59. 33 A N

ATOM 1705 C ARG A 127 -29. ,508 -0. 153 18. ,144 1.00 56. 00 A C

ATOM 1706 0 ARG A 127 -28. 355 -0. 359 18. ,524 1.00 57. 13 A 0

ATOM 1708 N VAL A 128 -29. ,990 -0. 647 17. ,013 1.00 55. 49 A N

ATOM 1709 CA VAL A 128 -29. 219 -1. 523 16. ,161 1.00 54. 95 A C

ATOM 1711 CB VAL A 128 -30. 149 -2. 405 15. ,322 1.00 52. 08 A c

ATOM 1713 CGI VAL A 128 -29. 350 -3. 312 14. ,378 1.00 44. 68 A c

ATOM 1717 CG2 VAL A 128 -31. 075 -3. 218 16. ,242 1.00 49. 59 A c

ATOM 1721 C VAL A 128 -28. 344 -0. 706 15. ,228 1.00 57. 45 A c

ATOM 1722 0 VAL A 128 -28. ,820 0. ,186 14. .499 1.00 54. ,19 A 0

ATOM 1724 N ASP A 129 -27. ,054 -1. 027 15. ,250 1.00 57. ,86 A N

ATOM 1725 CA ASP A 129 -26. ,064 -0. 247 14. ,551 1.00 56. ,36 A c

ATOM 1727 CB ASP A 129 -24. ,751 -0. 243 15. 331 1.00 51. ,89 A c

ATOM 1730 CG ASP A 129 -23. 748 0. 735 14. 772 1.00 48. ,61 A c

ATOM 1731 ODl ASP A 129 -24. 039 1. 362 13. ,744 1.00 44. ,52 A 0

ATOM 1732 OD2 ASP A 129 -22. 662 0. 868 15. 350 1.00 45. ,72 A 0

ATOM 1733 C ASP A 129 -25. 869 -0. 761 13. ,138 1.00 55. 26 A c

ATOM 1734 0 ASP A 129 -24. 927 -1. 488 12. ,847 1.00 48. 89 A 0

ATOM 1736 N ARG A 130 -26. ,780 -0. 365 12. .259 1.00 57. ,45 A N

ATOM 1737 CA ARG A 130 -26. ,550 -0. ,492 10. ,839 1.00 58. ,19 A c

ATOM 1739 CB ARG A 130 -26. ,928 -1. ,878 10. .301 1.00 70. ,29 A c

ATOM 1742 CG ARG A 130 -28. ,174 -2. 508 10. .875 1.00 74. ,37 A c

ATOM 1745 CD ARG A 130 -29. 433 -1. 799 10. ,391 1.00 81. ,38 A c

ATOM 1748 NE ARG A 130 -30. ,660 -2. 508 10. .770 1.00 82. ,96 A N

ATOM 1750 CZ ARG A 130 -31. 098 -3. 635 10. ,199 1.00 86. ,77 A c

ATOM 1751 NHl ARG A 130 -30. 413 -4. 229 9. ,211 1.00 88. ,68 A N

ATOM 1754 NH2 ARG A 130 -32. 229 -4. 180 10. ,627 1.00 82. ,41 A N

ATOM 1757 C ARG A 130 -27. ,234 0. ,641 10. ,090 1.00 54. ,91 A C

ATOM 1758 0 ARG A 130 -28. ,197 1. 236 10. ,573 1.00 50, ,74 A 0

ATOM 1760 N ASP A 131 -26. ,695 0. ,950 8. ,915 1.00 50, ,40 A N

ATOM 1761 CA ASP A 131 -27. ,135 2. ,100 8. ,143 1.00 48. ,43 A C human fD_Fab

ATOM 1763 CB ASP A 131 -26. 306 2. 246 6. 867 1.00 47. ,70 A C

ATOM 1766 CG ASP A 131 -25. 047 3 . 037 7. 060 1.00 44. 01 A C

ATOM 1767 ODl ASP A 131 -24. 899 3 . 710 8. 100 1.00 41.41 A 0

ATOM 1768 OD2 ASP A 131 -24. 207 2. 985 6. 138 1.00 41. ,76 A 0

ATOM 1769 C ASP A 131 -28. ,567 2. ,006 7. 702 1.00 44. ,62 A C

ATOM 1770 O ASP A 131 -29. ,042 0. 950 7. 312 1.00 48. ,72 A 0

ATOM 1772 N VAL A 132 -29. 246 3 . 136 7. 715 1.00 43. ,05 A N

ATOM 1773 CA VAL A 132 -30. 486 3 . 265 6. 979 1.00 40. ,82 A c

ATOM 1775 CB VAL A 132 -31. 152 4. 598 7. 225 1.00 36.97 A c

ATOM 1777 CGl VAL A 132 -32. 424 4. 702 6. 395 1.00 39. 65 A c

ATOM 1781 CG2 VAL A 132 -31. 456 4. 742 8. 674 1.00 35. 91 A c

ATOM 1785 C VAL A 132 -30. 134 3. 122 5. 504 1.00 41.80 A c

ATOM 1786 O VAL A 132 -29. 155 3 . ,679 5. 036 1.00 43. , 66 A 0

ATOM 1788 N ALA A 133 -30. 934 2. 347 4. 791 1.00 45. ,37 A N

ATOM 1789 CA ALA A 133 -30. 718 2. 102 3 . 373 1.00 41. ,03 A C

ATOM 1791 CB ALA A 133 -31. 801 1. 132 2. 846 1.00 36. 86 A c

ATOM 1795 C ALA A 133 -30. 758 3 . 414 2. 581 1.00 37. 89 A c

ATOM 1796 O ALA A 133 -31. 562 4. 309 2. 890 1.00 38. 61 A 0

ATOM 1798 N PRO A 134 -29. 892 3. 545 1. 563 1.00 36. 46 A N

ATOM 1799 CA PRO A 134 -29. 977 4. 671 0. 632 1.00 37. 07 A c

ATOM 1801 CB PRO A 134 -28. 945 4. 320 -0. 432 1.00 40. 39 A c

ATOM 1804 CG PRO A 134 -27. 940 3 . 464 0. 278 1.00 39. ,21 A c

ATOM 1807 CD PRO A 134 -28. 761 2. 652 1. 241 1.00 39. ,07 A c

ATOM 1810 C PRO A 134 -31. 366 4. 802 0. 013 1.00 40.84 A c

ATOM 1811 O PRO A 134 -32. 024 3 . 797 -0. 243 1.00 44. 50 A 0

ATOM 1812 N GLY A 135 -31.821 6. 034 -0. 186 1.00 39. 61 A N

ATOM 1813 CA GLY A 135 -33 . 135 6. 291 -0. 738 1.00 38. 34 A c

ATOM 1816 C GLY A 135 -34. 275 6. 255 0. 261 1.00 39. 46 A c

ATOM 1817 O GLY A 135 -35. 366 6. 766 -0. 020 1.00 40. 78 A 0

ATOM 1819 N THR A 136 -34. 052 5. 648 1. 418 1.00 37. ,77 A N

ATOM 1820 CA THR A 136 -35. 087 5. 580 2. 458 1.00 39. ,41 A C

ATOM 1822 CB THR A 136 -34. 534 4. 964 3 . 749 1.00 36. ,87 A C

ATOM 1824 OGl THR A 136 -33. 934 3 . 699 3 . 448 1.00 34. ,97 A 0

ATOM 1826 CG2 THR A 136 -35. 630 4. 798 4. 809 1.00 34. 42 A C

ATOM 1830 C THR A 136 -35. 574 6. 988 2. 775 1.00 39. 88 A c

ATOM 1831 O THR A 136 -34. 776 7. 890 2. 906 1.00 44. 04 A 0

ATOM 1833 N LEU A 137 -36. 873 7. 167 2. 908 1.00 42. 42 A N

ATOM 1834 CA LEU A 137 -37. 446 8. 507 3 . 028 1.00 43. ,50 A c

ATOM 1836 CB LEU A 137 -38. 768 8. 576 2. 258 1.00 48. ,15 A c

ATOM 1839 CG LEU A 137 -38. 998 9. 780 1. 342 1.00 50. ,05 A c

ATOM 1841 CDl LEU A 137 -37. 799 10. 070 0. 474 1.00 50. ,80 A c

ATOM 1845 CD2 LEU A 137 -40. 204 9. 499 0. 481 1.00 48. ,54 A c

ATOM 1849 C LEU A 137 -37. 661 8. 820 4. 498 1.00 44. ,18 A c

ATOM 1850 0 LEU A 137 -38. 449 8. 139 5. 161 1.00 45. ,74 A 0

ATOM 1852 N CYS A 138 -36. 936 9. 826 5. 008 1.00 41. ,15 A N

ATOM 1853 CA CYS A 138 -36. 949 10. 158 6. 431 1.00 37. 84 A c

ATOM 1855 CB CYS A 138 -35. 573 10. ,017 7. 070 1.00 37. ,40 A c

ATOM 1858 SG CYS A 138 -34. 773 8. ,455 6. 806 1.00 43. ,05 A S

ATOM 1860 C CYS A 138 -37. 459 11. ,563 6. 672 1.00 35. 64 A c

ATOM 1861 0 CYS A 138 -37. 437 12. ,409 5. 798 1.00 32. 56 A 0

ATOM 1863 N ASP A 139 -37. 892 11. ,801 7. 897 1.00 39. 34 A N

ATOM 1864 CA ASP A 139 -38. 601 13. 015 8. 258 1.00 38. ,90 A c

ATOM 1866 CB ASP A 139 -39. 915 12. 604 8. 925 1.00 38. 83 A c

ATOM 1869 CG ASP A 139 -40. 897 13. 730 9. 017 1.00 39. ,10 A c

ATOM 1870 ODl ASP A 139 -40. 831 14. ,649 8. 205 1.00 36. ,42 A 0

ATOM 1871 OD2 ASP A 139 -41. 757 13. ,679 9. 902 1.00 43. 88 A 0

ATOM 1872 C ASP A 139 -37. 752 13. ,826 9. 229 1.00 37. ,70 A c

ATOM 1873 0 ASP A 139 -37. 428 13. ,346 10. 328 1.00 35. ,55 A 0

ATOM 1875 N VAL A 140 -37. 367 15. ,036 8. 822 1.00 36. ,26 A N

ATOM 1876 CA VAL A 140 -36. 714 15. ,974 9. 735 1.00 36. ,61 A c

ATOM 1878 CB VAL A 140 -35. 296 16. ,374 9. 228 1.00 37. ,18 A c

ATOM 1880 CGl VAL A 140 -35. 375 17. ,121 7. 915 1.00 39. ,07 A c

ATOM 1884 CG2 VAL A 140 -34. 531 17. ,220 10. 272 1.00 36. ,57 A c

ATOM 1888 C VAL A 140 -37. 659 17. ,174 10. 010 1.00 35. ,17 A c

ATOM 1889 0 VAL A 140 -38. 335 17. ,676 9. ,115 1.00 30. ,43 A 0

ATOM 1891 N ALA A 141 -37. 768 17. 570 11.275 1.00 37. ,52 A N

ATOM 1892 CA ALA A 141 -38. 592 18. ,724 11. 658 1.00 37. ,71 A C

ATOM 1894 CB ALA A 141 -39. 822 18. 292 12. 493 1.00 36. ,75 A C human fD_Fab

ATOM 1898 C ALA A 141 -37. 749 19. 718 12. 426 1.00 37. 85 A C

ATOM 1899 O ALA A 141 -36. 688 19. 354 13. 000 1.00 32. 37 A 0

ATOM 1901 N GLY A 142 -38. 215 20. ,969 12. 424 1.00 37. 47 A N

ATOM 1902 CA GLY A 142 -37. 528 22. 027 13. 142 1.00 39. 53 A C

ATOM 1905 C GLY A 142 -38. 056 23. 434 12. 962 1.00 39. 91 A C

ATOM 1906 O GLY A 142 -38. 888 23. 712 12. 085 1.00 34. 47 A 0

ATOM 1908 N T P A 143 -37. 532 24. 332 13. 797 1.00 40. 62 A N

ATOM 1909 CA TRP A 143 -37. 880 25. 746 13. 733 1.00 40. 77 A C

ATOM 1911 CB TRP A 143 -38. 228 26. 277 15. 126 1.00 36. 15 A C

ATOM 1914 CG TRP A 143 -39. 550 25. 865 15. 693 1.00 34. 52 A C

ATOM 1915 CDl TRP A 143 -40. 733 26. 515 15. 527 1.00 35. 50 A C

ATOM 1917 NEl TRP A 143 -41. 713 25. 898 16. 250 1.00 36. 17 A N

ATOM 1919 CE2 TRP A 143 -41. 179 24. 826 16. 918 1.00 33. 81 A C

ATOM 1920 CD2 TRP A 143 -39. 815 24. 768 16. 590 1.00 26. 46 A C

ATOM 1921 CE3 TRP A 143 -39. 025 23. 770 17. 167 1.00 31. 02 A C

ATOM 1923 CZ3 TRP A 143 -39. 620 22. 858 18. Oil 1.00 34. 92 A C

ATOM 1925 CH2 TRP A 143 -40. 998 22. 921 18. 298 1.00 34. 20 A C

ATOM 1927 CZ2 TRP A 143 -41. 787 23. 905 17. 772 1.00 34. 41 A C

ATOM 1929 C TRP A 143 -36. 731 26. 561 13. 150 1.00 36. 86 A C

ATOM 1930 O TRP A 143 -36. 637 27. 751 13. 400 1.00 37. 75 A 0

ATOM 1932 N GLY A 144 -35. 873 25. 924 12. 364 1.00 38. 69 A N

ATOM 1933 CA GLY A 144 -34. 729 26. 599 11. 757 1.00 39. 16 A C

ATOM 1936 C GLY A 144 -35. 109 27. 384 10. 520 1.00 38. 42 A c

ATOM 1937 O GLY A 144 -36. 240 27. 320 10. 077 1.00 37. 08 A 0

ATOM 1939 N ILE A 145 -34. 157 28. 111 9. 946 1.00 42. 31 A N

ATOM 1940 CA ILE A 145 -34. 445 28. 986 8. 800 1.00 42. 33 A c

ATOM 1942 CB ILE A 145 -33. 175 29. 777 8. 293 1.00 39. 85 A c

ATOM 1944 CGI ILE A 145 -32. 274 28. 909 7. 417 1.00 41.88 A c

ATOM 1947 CDl ILE A 145 -30. 951 29. 589 6. 997 1.00 44. 49 A c

ATOM 1951 CG2 ILE A 145 -32. 371 30. 314 9. 436 1.00 34. 62 A c

ATOM 1955 C ILE A 145 -35. 115 28. 247 7. 614 1.00 41. 51 A c

ATOM 1956 0 ILE A 145 -34. 803 27. 081 7. 317 1.00 38. 57 A 0

ATOM 1958 N VAL A 146 -36. 037 28. 957 6. 955 1.00 43. 53 A N

ATOM 1959 CA VAL A 146 -36. 881 28. 409 5. 892 1.00 41. ,17 A c

ATOM 1961 CB VAL A 146 -38. 384 28. 657 6. 174 1.00 39. 49 A c

ATOM 1963 CGl VAL A 146 -38. 888 27. 786 7. 350 1.00 36. ,15 A c

ATOM 1967 CG2 VAL A 146 -38. 653 30. 133 6. 425 1.00 35. 62 A c

ATOM 1971 C VAL A 146 -36. 559 28. 996 4. 511 1.00 44. 43 A c

ATOM 1972 0 VAL A 146 -37. 202 28. 633 3. 504 1.00 40. 71 A 0

ATOM 1974 N ASN A 147 -35. 588 29. 914 4. 472 1.00 42. 90 A N

ATOM 1975 CA ASN A 147 -35. 122 30. 513 3. 223 1.00 44. 80 A c

ATOM 1977 CB ASN A 147 -36. 101 31. 590 2. 690 1.00 43. 45 A c

ATOM 1980 CG ASN A 147 -36. 104 32. 889 3. 512 1.00 41.14 A c

ATOM 1981 ODl ASN A 147 -35. 173 33. 181 4. 270 1.00 36. 71 A 0

ATOM 1982 ND2 ASN A 147 -37. 148 33. 689 3. 329 1.00 37. 21 A N

ATOM 1985 C ASN A 147 -33. 718 31. 060 3. 396 1.00 46. ,56 A c

ATOM 1986 0 ASN A 147 -33. 194 31. ,097 4. 510 1.00 48. ,44 A 0

ATOM 1988 N HIS A 148 -33. 114 31. 465 2. 287 1.00 48. 59 A N

ATOM 1989 CA HIS A 148 -31. 741 31. ,979 2. 281 1.00 50. 16 A c

ATOM 1991 CB HIS A 148 -31. 152 31. ,881 0. 880 1.00 51. 69 A c

ATOM 1994 CG HIS A 148 -31. 045 30. ,479 0. 368 1.00 55. 88 A c

ATOM 1995 NDl HIS A 148 -30. 188 29. ,549 0. 919 1.00 56. 47 A N

ATOM 1997 CEl HIS A 148 -30. 308 28. 407 0. 266 1.00 56. 86 A C

ATOM 1999 NE2 HIS A 148 -31. 209 28. 560 -0. 688 1.00 57. 60 A N

ATOM 2001 CD2 HIS A 148 -31. 687 29. 848 -0. 645 1.00 57. ,94 A C

ATOM 2003 C HIS A 148 -31. 582 33. 401 2. 800 1.00 49. ,10 A c

ATOM 2004 0 HIS A 148 -30. 453 33. ,839 3. 012 1.00 50. ,47 A 0

ATOM 2006 N ALA A 149 -32. 697 34. ,108 2. 999 1.00 48. ,35 A N

ATOM 2007 CA ALA A 149 -32. 712 35. ,401 3. 700 1.00 50. ,44 A c

ATOM 2009 CB ALA A 149 -33. 958 36. ,169 3. 351 1.00 34. ,90 A c

ATOM 2013 C ALA A 149 -32. 613 35. ,272 5. 227 1.00 53. ,69 A c

ATOM 2014 0 ALA A 149 -32. 592 36. ,278 5. 940 1.00 56. 86 A 0

ATOM 2016 N GLY A 150 -32. 593 34. ,041 5. 725 1.00 55. ,55 A N

ATOM 2017 CA GLY A 150 -32. 489 33. ,776 7. 146 1.00 55. ,44 A c

ATOM 2020 C GLY A 150 -33. 772 33. ,947 7. 939 1.00 54. ,50 A c

ATOM 2021 0 GLY A 150 -33. 702 34. ,154 9. 148 1.00 52. ,01 A 0

ATOM 2023 N ARG A 151 -34. 937 33. 852 7. 287 1.00 57. 28 A N

ATOM 2024 CA ARG A 151 -36. 219 33. 955 7. 996 1.00 58. ,48 A c human fD_Fab

ATOM 2026 CB ARG A 151 -37. ,414 33. 950 7. ,034 1. 00 57. 67 A C

ATOM 2029 CG ARG A 151 -38. 741 34. ,183 7. ,748 1. 00 58. 97 A C

ATOM 2032 CD ARG A 151 -39. 673 35. 111 7. ,040 1. 00 65. 28 A C

ATOM 2035 NE ARG A 151 -40. 025 34. 644 5. 707 1. 00 69. 75 A N

ATOM 2037 cz ARG A 151 -40. 773 33. 571 5. 432 1. 00 72. 89 A C

ATOM 2038 NHl ARG A 151 -41. 262 32. 785 6. 391 1. 00 73. 75 A N

ATOM 2041 NH2 ARG A 151 -41. ,037 33. ,273 4. ,162 1. 00 73. 33 A N

ATOM 2044 C ARG A 151 -36. ,203 32. ,791 9. ,004 1. 00 57. 87 A C

ATOM 2045 O ARG A 151 -35. ,174 32. ,210 9. ,197 1. 00 60. 51 A 0

ATOM 2047 N ARG A 152 -37. 313 32. ,425 9. ,608 1. 00 59. 47 A N

ATOM 2048 CA ARG A 152 -37. ,374 31. ,773 10. 912 1. 00 56. 90 A C

ATOM 2050 CB ARG A 152 -36. 818 32. ,599 12. ,082 1. 00 62. 78 A C

ATOM 2053 CG ARG A 152 -35. 303 32. ,885 12. ,141 1. 00 66. 60 A c

ATOM 2056 CD ARG A 152 -34. 399 31.707 11.801 1. 00 69. 59 A c

ATOM 2059 NE ARG A 152 -33. 990 30. 879 12. 935 1. 00 70. 08 A N

ATOM 2061 CZ ARG A 152 -32. 745 30. 775 13. 414 1. 00 69. 62 A c

ATOM 2062 NHl ARG A 152 -32. 507 29. 957 14. 433 1. 00 69. 04 A N

ATOM 2065 NH2 ARG A 152 -31. 731 31. ,471 12. ,899 1. 00 69. 66 A N

ATOM 2068 C ARG A 152 -38. 874 31. ,614 11. ,029 1. 00 50. 16 A c

ATOM 2069 O ARG A 152 -39. 594 32. ,592 11. ,045 1. 00 48. 56 A 0

ATOM 2071 N PRO A 153 -39. 357 30. ,375 11. ,038 1. 00 48. 68 A N

ATOM 2072 CA PRO A 153 -40. 798 30. ,179 11. ,122 1. 00 47. 58 A C

ATOM 2074 CB PRO A 153 -40. 959 28. ,719 10. 715 1. 00 44. 69 A C

ATOM 2077 CG PRO A 153 -39. 689 28. 059 11. ,206 1. 00 39. 90 A c

ATOM 2080 CD PRO A 153 -38. 622 29. 094 11. ,003 1. 00 43. 66 A c

ATOM 2083 C PRO A 153 -41. 320 30. 394 12. 544 1. 00 46. 97 A c

ATOM 2084 O PRO A 153 -40. 578 30. 251 13. 507 1. 00 48. 12 A 0

ATOM 2085 N ASP A 154 -42. 594 30. 719 12. 684 1. 00 45. 48 A N

ATOM 2086 CA ASP A 154 -43. 170 30. ,786 14. ,014 1. 00 44. 44 A c

ATOM 2088 CB ASP A 154 -44. 380 31. ,727 14. ,109 1. 00 41. 53 A c

ATOM 2091 CG ASP A 154 -45. 032 31. 672 15. ,488 1. 00 39. 90 A c

ATOM 2092 ODl ASP A 154 -44. 490 32. 293 16. 427 1. 00 38. 75 A 0

ATOM 2093 OD2 ASP A 154 -46. 057 30. 978 15. 638 1. 00 35. 47 A 0

ATOM 2094 C ASP A 154 -43. 569 29. 389 14. ,447 1. 00 40. 16 A c

ATOM 2095 0 ASP A 154 -43. 288 28. 994 15. ,573 1. 00 36. 68 A 0

ATOM 2097 N SER A 155 -44. 216 28. 639 13. ,555 1. 00 41. 05 A N

ATOM 2098 CA SER A 155 -44. 588 27. 250 13. ,858 1. 00 42. 47 A c

ATOM 2100 CB SER A 155 -46. 040 26. ,978 13. ,474 1. 00 41. 45 A c

ATOM 2103 OG SER A 155 -46. 312 27. .377 12. ,149 1. 00 46. 34 A 0

ATOM 2105 C SER A 155 -43. 654 26. .188 13. ,239 1. 00 43. 44 A c

ATOM 2106 0 SER A 155 -42. 904 26. ,455 12. ,277 1. 00 41. 58 A 0

ATOM 2108 N LEU A 156 -43. 720 24. ,987 13. ,816 1. 00 41. 33 A N

ATOM 2109 CA LEU A 156 -42. 863 23. ,864 13. ,444 1. 00 42. 92 A c

ATOM 2111 CB LEU A 156 -43. 144 22. ,677 14. ,382 1. 00 42. 64 A c

ATOM 2114 CG LEU A 156 -42. 266 21.442 14. 220 1. 00 40. 09 A c

ATOM 2116 CDl LEU A 156 -40. 893 21. ,795 14. ,703 1. 00 31. 96 A c

ATOM 2120 CD2 LEU A 156 -42. 873 20. ,204 14. ,959 1. 00 34. 86 A c

ATOM 2124 C LEU A 156 -43. 045 23. ,424 11.979 1. 00 42. 41 A c

ATOM 2125 0 LEU A 156 -44. 168 23. ,285 11. ,491 1. 00 37. 99 A 0

ATOM 2127 N GLN A 157 -41. 918 23. .212 11.302 1. 00 44. 06 A N

ATOM 2128 CA GLN A 157 -41. 878 22. .811 9. .899 1. 00 44. 55 A c

ATOM 2130 CB GLN A 157 -40. 993 23. ,768 9. .092 1. 00 43. ,27 A c

ATOM 2133 CG GLN A 157 -41. ,327 25. .206 9. ,223 1. 00 40. ,04 A c

ATOM 2136 CD GLN A 157 -42. 491 25. ,601 8. .352 1. 00 43. 07 A c

ATOM 2137 OEl GLN A 157 -42. 475 25. .368 7. ,137 1. 00 44. 65 A 0

ATOM 2138 NE2 GLN A 157 -43. 497 26. .234 8. ,956 1. 00 34. 27 A N

ATOM 2141 C GLN A 157 -41. 258 21. ,443 9. ,787 1. 00 42. 62 A c

ATOM 2142 0 GLN A 157 -40. 615 20. ,981 10. ,719 1. 00 41. 92 A 0

ATOM 2144 N HIS A 158 -41. 416 20. ,813 8. ,629 1. 00 42. 05 A N

ATOM 2145 CA HIS A 158 -40. 799 19. ,522 8. ,399 1. 00 44. 73 A C

ATOM 2147 CB HIS A 158 -41. 643 18. .415 9. ,052 1. 00 45. ,15 A C

ATOM 2150 CG HIS A 158 -42. ,773 17. .932 8. .207 1. 00 42. ,71 A C

ATOM 2151 NDl HIS A 158 -43. ,941 18. ,649 8. .051 1. 00 44. ,34 A N

ATOM 2153 CEl HIS A 158 -44. ,748 17. .992 7. ,240 1. 00 46. ,07 A c

ATOM 2155 NE2 HIS A 158 -44. 147 16. .873 6. ,869 1. 00 46. 91 A N

ATOM 2157 CD2 HIS A 158 -42. 913 16. .808 7. ,464 1. 00 39. 06 A C

ATOM 2159 C HIS A 158 -40. 582 19. ,261 6. ,914 1. 00 45. 23 A c

ATOM 2160 0 HIS A 158 -41. 121 19. .971 6, ,068 1. 00 45. ,76 A 0 human fD_Fab

ATOM 2162 N VAL A 159 -39. 773 18. ,247 6. 610 1.00 42. ,85 A N

ATOM 2163 CA VAL A 159 -39. 509 17. ,849 5. 218 1.00 44. ,46 A C

ATOM 2165 CB VAL A 159 -38. 377 18. ,727 4. 543 1.00 40. ,51 A C

ATOM 2167 CGI VAL A 159 -36. 990 18. ,315 5. 020 1.00 36. ,60 A C

ATOM 2171 CG2 VAL A 159 -38. 467 18. ,658 3. 037 1.00 31. 26 A C

ATOM 2175 C VAL A 159 -39. 142 16. ,372 5. 146 1.00 43. ,03 A c

ATOM 2176 0 VAL A 159 -38. 463 15. ,856 6. 035 1.00 39. ,12 A 0

ATOM 2178 N LEU A 160 -39. 606 15. ,698 4. 098 1.00 45. ,51 A N

ATOM 2179 CA LEU A 160 -39. 172 14. ,323 3. 808 1.00 47. ,40 A c

ATOM 2181 CB LEU A 160 -40. 261 13. ,498 3. 112 1.00 49. ,83 A c

ATOM 2184 CG LEU A 160 -41. ,089 12. ,623 4. 033 1.00 49. ,40 A c

ATOM 2186 CDl LEU A 160 -41. 633 13. ,473 5. 154 1.00 50. ,44 A c

ATOM 2190 CD2 LEU A 160 -42. 199 11. ,971 3. 235 1.00 49. ,87 A c

ATOM 2194 C LEU A 160 -37. 936 14. ,340 2. 935 1.00 45. ,22 A c

ATOM 2195 0 LEU A 160 -37. 911 15. ,004 1. 913 1.00 45. ,19 A 0

ATOM 2197 N LEU A 161 -36. 920 13. ,592 3. 351 1.00 42. 96 A N

ATOM 2198 CA LEU A 161 -35. 634 13. ,594 2. 694 1.00 43. 40 A c

ATOM 2200 CB LEU A 161 -34. 591 14. ,346 3. 539 1.00 43. ,07 A c

ATOM 2203 CG LEU A 161 -34. 879 15. ,796 3. 937 1.00 39. ,52 A c

ATOM 2205 CDl LEU A 161 -33. ,810 16. ,315 4. 893 1.00 39. ,37 A c

ATOM 2209 CD 2 LEU A 161 -34. 995 16. ,701 2. 707 1.00 39. ,15 A c

ATOM 2213 C LEU A 161 -35. 187 12. ,160 2. 482 1.00 43. ,31 A c

ATOM 2214 0 LEU A 161 -35. 307 11. ,349 3. 386 1.00 44. ,13 A 0

ATOM 2216 N PRO A 162 -34. 679 11. ,839 1. 283 1.00 43. ,26 A N

ATOM 2217 CA PRO A 162 -34. 068 10. ,532 1. 057 1.00 40. .13 A C

ATOM 2219 CB PRO A 162 -34. 038 10. ,390 -0. 471 1.00 41. ,24 A C

ATOM 2222 CG PRO A 162 -34. 565 11. ,675 -1. 037 1.00 48. ,49 A C

ATOM 2225 CD PRO A 162 -34. 679 12. ,676 0. 070 1.00 48. ,01 A C

ATOM 2228 C PRO A 162 -32. 647 10. ,427 1. 601 1.00 40. ,60 A c

ATOM 2229 0 PRO A 162 -31. 813 11. 299 1. 354 1.00 36. ,37 A 0

ATOM 2230 N VAL A 163 -32. 379 9. ,355 2. 330 1.00 39. ,55 A N

ATOM 2231 CA VAL A 163 -31. 032 9. ,065 2. 763 1.00 39. ,40 A c

ATOM 2233 CB VAL A 163 -30. 956 7. ,757 3. 593 1.00 42. ,89 A c

ATOM 2235 CGI VAL A 163 -29. 541 7. ,267 3. 701 1.00 35. ,35 A c

ATOM 2239 CG2 VAL A 163 -31. 570 7. ,965 4. 992 1.00 42. ,51 A c

ATOM 2243 C VAL A 163 -30. 114 8. ,975 1. 536 1.00 42. ,15 A c

ATOM 2244 0 VAL A 163 -30. 477 8. ,401 0. 502 1.00 42. ,10 A 0

ATOM 2246 N LEU A 164 -28. 932 9. ,577 1. 675 1.00 41.57 A N

ATOM 2247 CA LEU A 164 -27. 919 9. ,566 0. 670 1.00 37. ,06 A c

ATOM 2249 CB LEU A 164 -27. 456 11. ,005 0. 439 1.00 41.05 A c

ATOM 2252 CG LEU A 164 -26. 429 11. ,203 -0. 670 1.00 41. ,57 A c

ATOM 2254 CDl LEU A 164 -27. 047 10. ,795 -2. 001 1.00 45. ,00 A c

ATOM 2258 CD2 LEU A 164 -25. 922 12. 631 -0. 709 1.00 40. ,98 A c

ATOM 2262 C LEU A 164 -26. 787 8. ,673 1. 181 1.00 37. ,55 A c

ATOM 2263 0 LEU A 164 -26. 374 8. ,807 2. 329 1.00 39. ,36 A 0

ATOM 2265 N ASP A 165 -26. 299 7. ,752 0. 343 1.00 38. ,67 A N

ATOM 2266 CA ASP A 165 -25. 259 6. ,814 0. 764 1.00 34, .02 A c

ATOM 2268 CB ASP A 165 -25. 021 5. ,713 -0. 274 1.00 34, .85 A c

ATOM 2271 CG ASP A 165 -24. 223 6. ,185 -1. 468 1.00 39, .94 A c

ATOM 2272 001 ASP A 165 -24. 768 6. ,928 -2. 313 1.00 40, .37 A 0

ATOM 2273 002 ASP A 165 -23. 043 5. ,791 -1. 571 1.00 42, .24 A 0

ATOM 2274 C ASP A 165 -23. 965 7. ,556 1. 066 1.00 33, .34 A c

ATOM 2275 0 ASP A 165 -23. 725 8. ,649 0. 531 1.00 32, .61 A 0

ATOM 2277 N ARG A 166 -23. 131 6, ,931 1. 903 1.00 29, .45 A N

ATOM 2278 CA ARG A 166 -21. 949 7. ,558 2. 432 1.00 30, .14 A c

ATOM 2280 CB ARG A 166 -21. 367 6. .704 3. 555 1.00 32, .72 A c

ATOM 2283 CG ARG A 166 -20. 189 7. ,359 4. 305 1.00 35. .16 A c

ATOM 2286 CD ARG A 166 -19. 898 6. ,687 5. 662 1.00 32. .27 A c

ATOM 2289 NE ARG A 166 -21. 056 6. .758 6. 544 1.00 33, .16 A N

ATOM 2291 CZ ARG A 166 -21. 899 5. .762 6. 780 1.00 36, .14 A c

ATOM 2292 NHl ARG A 166 -21. ,738 4. ,577 6. 208 1.00 34, .13 A N

ATOM 2295 NH2 ARG A 166 -22. 926 5. ,962 7. 597 1.00 33, .96 A N

ATOM 2298 C ARG A 166 -20. 881 7. ,809 1. 361 1.00 33, .09 A C

ATOM 2299 0 ARG A 166 -20. ,160 8. ,811 1. 432 1.00 33, .92 A 0

ATOM 2301 N ALA A 167 -20. 768 6. ,903 0. 388 1.00 30, .20 A N

ATOM 2302 CA ALA A 167 -19. 770 7. ,041 -0. 658 1.00 29, .35 A C

ATOM 2304 CB ALA A 167 -19. 646 5. ,748 -1. 545 1.00 22, .50 A c

ATOM 2308 C ALA A 167 -20. 104 8. ,264 -1. ,471 1.00 29, .35 A c human fD _Fab

ATOM 2309 O ALA A 167 -19. ,282 9. 156 -1. 626 1.00 36. 53 A 0

ATOM 2311 N THR A 168 -21. ,326 8. 365 -1. 943 1.00 30. ,11 A N

ATOM 2312 CA THR A 168 -21. ,747 9. 594 -2. 644 1.00 32. 69 A C

ATOM 2314 CB THR A 168 -23. 235 9. 561 -3. 009 1.00 32. 60 A C

ATOM 2316 OGl THR A 168 -23. ,504 8. 411 -3. 816 1.00 30. 46 A 0

ATOM 2318 CG2 THR A 168 -23. ,659 10. 831 -3. 752 1.00 31. ,41 A C

ATOM 2322 C THR A 168 -21. ,513 10. 844 -1. 791 1.00 35. ,88 A c

ATOM 2323 O THR A 168 -21. ,073 11.884 -2. 280 1.00 36. 06 A 0

ATOM 2325 N CYS A 169 -21. ,813 10. 738 -0. 501 1.00 37. ,03 A N

ATOM 2326 CA CYS A 169 -21. ,654 11. 875 0. 394 1.00 35. 32 A c

ATOM 2328 CB CYS A 169 -22. 320 11. 600 1. 745 1.00 35. 01 A c

ATOM 2331 SG CYS A 169 -22. 912 13. 131 2. 437 1.00 38. 59 A s

ATOM 2333 C CYS A 169 -20. ,188 12. 303 0. 601 1.00 36. 35 A c

ATOM 2334 O CYS A 169 -19. ,909 13. 470 0. 914 1.00 35. ,05 A 0

ATOM 2336 N ASN A 170 -19. ,276 11.340 0. 459 1.00 36. ,34 A N

ATOM 2337 CA ASN A 170 -17. ,864 11. 569 0. 643 1.00 35. ,95 A c

ATOM 2339 CB ASN A 170 -17. 227 10. 334 1. 279 1.00 37. ,51 A c

ATOM 2342 CG ASN A 170 -17. ,286 10. 377 2. 771 1.00 34. 09 A c

ATOM 2343 ODl ASN A 170 -17. ,147 11. 439 3. 359 1.00 36. 99 A 0

ATOM 2344 ND2 ASN A 170 -17. ,481 9. 225 3. 401 1.00 35. 29 A N

ATOM 2347 C ASN A 170 -17. ,076 11. 997 -0. 619 1.00 37. 38 A c

ATOM 2348 O ASN A 170 -15. ,844 12. 225 -0. 563 1.00 36. ,39 A 0

ATOM 2350 N ARG A 171 -17. 778 12. 135 -1. 735 1.00 33. ,37 A N

ATOM 2351 CA ARG A 171 -17. ,174 12. 663 -2. 951 1.00 35. ,17 A c

ATOM 2353 CB ARG A 171 -18. ,210 12. 811 -4. 060 1.00 35. 92 A C

ATOM 2356 CG ARG A 171 -18. 870 11. 511 -4. 486 1.00 41. 00 A C

ATOM 2359 CD ARG A 171 -19. 026 11. 464 -5. 977 1.00 45. 26 A C

ATOM 2362 NE ARG A 171 -19. 745 12. 634 -6. 426 1.00 45. 08 A N

ATOM 2364 cz ARG A 171 -21. 050 12. 674 -6. 684 1.00 52. 64 A C

ATOM 2365 NHl ARG A 171 -21.594 13. 824 -7. 073 1.00 55. 26 A N

ATOM 2368 NH2 ARG A 171 -21. ,819 11. 585 -6. 583 1.00 48. ,32 A N

ATOM 2371 C ARG A 171 -16. ,558 14. 023 -2. 696 1.00 36. ,07 A C

ATOM 2372 O ARG A 171 -16. 988 14. 739 -1. 782 1.00 34. ,21 A 0

ATOM 2374 N ARG A 172 -15. 576 14. 412 -3. 516 1.00 35. 32 A N

ATOM 2375 CA ARG A 172 -14. ,899 15. 720 -3. 286 1.00 35. ,05 A C

ATOM 2377 CB ARG A 172 -13. ,718 15. 943 -4. 223 1.00 35. 37 A C

ATOM 2380 CG ARG A 172 -14. ,065 16. 317 -5. 630 1.00 34. 24 A c

ATOM 2383 CD ARG A 172 -12. ,840 16. 294 -6. 492 1.00 35. ,34 A c

ATOM 2386 NE ARG A 172 -12. ,237 14. 959 -6. 560 1.00 38. ,21 A N

ATOM 2388 CZ ARG A 172 -11. ,046 14. 688 -7. 101 1.00 40. ,10 A C

ATOM 2389 NHl ARG A 172 -10. ,289 15. 657 -7. 608 1.00 38. ,18 A N

ATOM 2392 NH2 ARG A 172 -10. ,593 13. 444 -7. 114 1.00 40. ,26 A N

ATOM 2395 C ARG A 172 -15. ,850 16. 906 -3. 420 1.00 35. ,61 A c

ATOM 2396 O ARG A 172 -15. ,688 17. 927 -2. 734 1.00 32. ,88 A 0

ATOM 2398 N THR A 173 -16. ,847 16. 741 -4. 299 1.00 35. ,32 A N

ATOM 2399 CA THR A 173 -17. ,841 17. 755 -4. 559 1.00 31. ,84 A C

ATOM 2401 CB THR A 173 -18. ,780 17. 373 -5. 699 1.00 31. ,65 A c

ATOM 2403 OGl THR A 173 -18. ,045 16. 842 -6. 802 1.00 39. ,07 A 0

ATOM 2405 CG2 THR A 173 -19. ,616 18. ,591 -6. 168 1.00 31. ,50 A c

ATOM 2409 C THR A 173 -18. ,718 17. ,998 -3. 327 1.00 37. ,18 A c

ATOM 2410 O THR A 173 -19. ,266 19. ,073 -3. 168 1.00 40. ,53 A 0

ATOM 2412 N HIS A 174 -18. ,867 16. 976 -2. 484 1.00 39. ,46 A N

ATOM 2413 CA HIS A 174 -19. ,766 16. 996 -1. 356 1.00 34. ,34 A C

ATOM 2415 CB HIS A 174 -20. ,615 15. ,720 -1. 335 1.00 36. .83 A C

ATOM 2418 CG HIS A 174 -21.535 15. ,599 -2. 515 1.00 38. ,56 A c

ATOM 2419 NDl HIS A 174 -21. ,877 14. ,391 -3. 080 1.00 40. ,71 A N

ATOM 2421 CEl HIS A 174 -22. ,706 14. ,594 -4. 090 1.00 40. ,10 A C

ATOM 2423 NE2 HIS A 174 -22. 903 15. ,889 -4. 209 1.00 41, ,44 A N

ATOM 2425 CD2 HIS A 174 -22. ,174 16. ,541 -3. 243 1.00 42. .80 A C

ATOM 2427 C HIS A 174 -18. 967 17. ,215 -0. 090 1.00 33. ,27 A C

ATOM 2428 O HIS A 174 -18. ,417 18. ,300 0. 083 1.00 39. ,26 A 0

ATOM 2430 N HIS A 175 -18. ,826 16. ,212 0. 771 1.00 36. .74 A N

ATOM 2431 CA HIS A 175 -18. ,122 16. ,408 2. 055 1.00 34. .92 A C

ATOM 2433 CB HIS A 175 -19. ,007 15. ,957 3. 224 1.00 37. .96 A C

ATOM 2436 CG HIS A 175 -20. ,281 16. 728 3. 335 1.00 30. .83 A C

ATOM 2437 NDl HIS A 175 -20. ,314 18. 060 3. 670 1.00 33. .14 A N

ATOM 2439 CEl HIS A 175 -21.565 18. 476 3. 682 1.00 37. ,37 A C

ATOM 2441 NE2 HIS A 175 -22. ,343 17. ,457 3. 373 1.00 32. ,52 A N human fD_Fab

ATOM 2443 CD2 HIS A 175 -21.562 16. .355 3. 147 1.00 29. ,73 A C

ATOM 2445 C HIS A 175 -16. ,759 15. .740 2. 160 1.00 36, ,04 A C

ATOM 2446 O HIS A 175 -16. 167 15. .733 3. 257 1.00 31. ,58 A 0

ATOM 2448 N ASP A 176 -16. ,297 15. .152 1. 055 1.00 35. ,29 A N

ATOM 2449 CA ASP A 176 -14. 863 14. .891 0. 815 1.00 37. ,38 A C

ATOM 2451 CB ASP A 176 -14. 145 16. ,244 0. 587 1.00 40. ,18 A C

ATOM 2454 CG ASP A 176 -12. 887 16. ,127 -0. 256 1.00 42. ,80 A C

ATOM 2455 ODl ASP A 176 -12. 664 15. ,064 -0. 864 1.00 45. ,47 A 0

ATOM 2456 OD2 ASP A 176 -12. 116 17. ,122 -0. 315 1.00 45. ,22 A 0

ATOM 2457 C ASP A 176 -14. 164 14. .052 1. 902 1.00 38. ,60 A C

ATOM 2458 O ASP A 176 -13. ,057 14. .391 2. 365 1.00 34. ,18 A 0

ATOM 2460 N GLY A 177 -14. 809 12. ,944 2. 289 1.00 35. ,76 A N

ATOM 2461 CA GLY A 177 -14. 217 11. .994 3. 235 1.00 33, ,97 A C

ATOM 2464 C GLY A 177 -14. 545 12. ,278 4. 674 1.00 34. ,54 A c

ATOM 2465 O GLY A 177 -14. 194 11. ,471 5. 556 1.00 36. ,61 A 0

ATOM 2467 N ALA A 178 -15. 232 13. ,396 4. 926 1.00 34, ,17 A N

ATOM 2468 CA ALA A 178 -15. 570 13. ,836 6. 287 1.00 33, .34 A C

ATOM 2470 CB ALA A 178 -16. 009 15. ,308 6. 243 1.00 32. ,67 A c

ATOM 2474 C ALA A 178 -16. 658 12. ,977 6. 956 1.00 35. .09 A c

ATOM 2475 O ALA A 178 -16. 825 13. ,001 8. 197 1.00 35. 68 A 0

ATOM 2477 N ILE A 179 -17. 387 12. ,209 6. 143 1.00 34. ,85 A N

ATOM 2478 CA ILE A 179 -18. 537 11. ,441 6. 619 1.00 33. ,31 A c

ATOM 2480 CB ILE A 179 -19. 607 11. ,325 5. 548 1.00 33. ,10 A c

ATOM 2482 CGI ILE A 179 -19. 876 12. ,702 4. 917 1.00 32. ,61 A c

ATOM 2485 CDl ILE A 179 -20. 518 13. ,742 5. 892 1.00 26, ,74 A c

ATOM 2489 CG2 ILE A 179 -20. 934 10. ,734 6. 163 1.00 33. ,35 A c

ATOM 2493 C ILE A 179 -18. 065 10. ,074 7. 064 1.00 32. ,66 A c

ATOM 2494 O ILE A 179 -17. 679 9. ,247 6. 228 1.00 31. ,85 A 0

ATOM 2496 N THR A 180 -18. 087 9. ,873 8. 389 1.00 32. ,08 A N

ATOM 2497 CA THR A 180 -17. 640 8. ,666 9. 052 1.00 35. ,33 A c

ATOM 2499 CB THR A 180 -17. 069 8. ,976 10. 479 1.00 33. ,07 A c

ATOM 2501 OGl THR A 180 -18. 126 9. ,422 11. 333 1.00 32. ,91 A 0

ATOM 2503 CG2 THR A 180 -15. 970 10. ,067 10. 446 1.00 27. 89 A c

ATOM 2507 C THR A 180 -18. 828 7. ,711 9. 189 1.00 40. ,80 A c

ATOM 2508 O THR A 180 -19. 955 8. ,028 8. 778 1.00 37. ,76 A 0

ATOM 2510 N GLU A 181 -18. 563 6. ,545 9. 777 1.00 42. ,59 A N

ATOM 2511 CA GLU A 181 -19. 592 5. ,537 9. 976 1.00 46. ,07 A c

ATOM 2513 CB GLU A 181 -18. 965 4. ,151 10. 239 1.00 52. ,78 A c

ATOM 2516 CG GLU A 181 -18. 696 3. ,397 8. 916 1.00 58. ,42 A c

ATOM 2519 CD GLU A 181 -17. 813 2. ,170 9. 052 1.00 60. ,39 A c

ATOM 2520 OEl GLU A 181 -16. 635 2. ,324 9. 451 1.00 68. ,43 A 0

ATOM 2521 OE2 GLU A 181 -18. 280 1, ,054 8. 707 1.00 65. ,42 A 0

ATOM 2522 C GLU A 181 -20. 592 5. ,914 11. 050 1.00 42, ,26 A c

ATOM 2523 O GLU A 181 -21. 602 5, ,234 11. 197 1.00 39. ,09 A 0

ATOM 2525 N ARG A 182 -20. 355 7. ,027 11. 750 1.00 41.52 A N

ATOM 2526 CA ARG A 182 -21. 281 7, .469 12. ,811 1.00 42, .98 A c

ATOM 2528 CB ARG A 182 -20. ,538 7. .807 14. ,116 1.00 49, ,75 A c

ATOM 2531 CG ARG A 182 -19. 086 7, ,427 14. 098 1.00 53, .11 A c

ATOM 2534 CD ARG A 182 -18. ,570 6. ,685 15. ,307 1.00 55, .33 A c

ATOM 2537 NE ARG A 182 -17. 822 5, .492 14. ,858 1.00 63, ,67 A N

ATOM 2539 CZ ARG A 182 -16. 805 5. .478 13. ,980 1.00 58. .31 A c

ATOM 2540 NHl ARG A 182 -16. 338 6. .585 13. ,414 1.00 53. ,04 A N

ATOM 2543 NH2 ARG A 182 -16. 234 4, ,322 13. ,667 1.00 62. .47 A N

ATOM 2546 C ARG A 182 -22. 114 8. .655 12. ,375 1.00 35. ,97 A c

ATOM 2547 0 ARG A 182 -22. 873 9. ,207 13. ,174 1.00 37. .71 A 0

ATOM 2549 N LEU A 183 -21. 958 9, ,050 11. ,117 1.00 34. .71 A N

ATOM 2550 CA LEU A 183 -22. 720 10. ,148 10. 535 1.00 37, ,15 A C

ATOM 2552 CB LEU A 183 -21. ,800 11.297 10. ,073 1.00 30. .19 A C

ATOM 2555 CG LEU A 183 -20. ,960 12. .009 11. ,161 1.00 32, .92 A c

ATOM 2557 CDl LEU A 183 -19. 906 12. .924 10. ,528 1.00 25, .12 A C

ATOM 2561 CD2 LEU A 183 -21. 838 12, .799 12. ,177 1.00 26, .48 A C

ATOM 2565 C LEU A 183 -23. 490 9. .566 9. ,356 1.00 35, ,94 A c

ATOM 2566 0 LEU A 183 -23. 047 8. .597 8. ,746 1.00 39, ,28 A 0

ATOM 2568 N MET A 184 -24. 650 10, .138 9. ,059 1.00 35, ,50 A N

ATOM 2569 CA MET A 184 -25. 404 9. .759 7. ,864 1.00 37, .11 A c

ATOM 2571 CB MET A 184 -26. 694 8, .985 8. ,198 1.00 36, .84 A c

ATOM 2574 CG MET A 184 -27. 614 9, .629 9. ,220 1.00 35, .25 A c

ATOM 2577 SD MET A 184 -29. 141 8, .700 9. ,560 1.00 36, .12 A S human fD_Fab

ATOM 2578 CE MET A 184 -29. 872 8. 750 7. 919 1.00 31. 31 A C

ATOM 2582 C MET A 184 -25. 716 11. ,014 7. 081 1.00 32. 51 A C

ATOM 2583 O MET A 184 -25. 638 12. ,108 7. 611 1.00 32. 39 A 0

ATOM 2585 N CYS A 185 -26. 058 10. ,839 5. 817 1.00 33. 27 A N

ATOM 2586 CA CYS A 185 -26. 361 11.948 4. 940 1.00 36. 65 A c

ATOM 2588 CB CYS A 185 -25. 371 11. ,982 3. 770 1.00 41. 74 A c

ATOM 2591 SG CYS A 185 -23. ,777 12. ,677 4. 200 1.00 41. 29 A S

ATOM 2593 C CYS A 185 -27. 762 11. ,835 4. 415 1.00 35. 13 A c

ATOM 2594 O CYS A 185 -28. 290 10. ,744 4. 295 1.00 36. 05 A 0

ATOM 2596 N ALA A 186 -28. 361 12. ,980 4. 113 1.00 35. 07 A N

ATOM 2597 CA ALA A 186 -29. 600 13. ,031 3. 364 1.00 36. 97 A c

ATOM 2599 CB ALA A 186 -30. 700 13. ,420 4. 251 1.00 34. 59 A c

ATOM 2603 C ALA A 186 -29. 415 14. ,055 2. 256 1.00 40. 76 A c

ATOM 2604 O ALA A 186 -28. 535 14. ,934 2. 356 1.00 43. 01 A 0

ATOM 2606 N GLU A 187 -30. 220 13. ,923 1. 201 1.00 41. 54 A N

ATOM 2607 CA GLU A 187 -30. ,200 14. ,851 0. 078 1.00 44. 50 A c

ATOM 2609 CB GLU A 187 -31. 098 14. ,354 -1. 070 1.00 48. 87 A c

ATOM 2612 CG GLU A 187 -30. 496 13. ,141 -1. 834 1.00 52. 00 A c

ATOM 2615 CD GLU A 187 -31. 376 12. 633 -2. 986 1.00 54. 41 A c

ATOM 2616 OEl GLU A 187 -32. 154 13. ,437 -3. 559 1.00 58. 93 A 0

ATOM 2617 OE2 GLU A 187 -31. 284 11. ,426 -3. 314 1.00 51. 51 A 0

ATOM 2618 C GLU A 187 -30. 582 16. ,265 0. 511 1.00 42. 90 A c

ATOM 2619 O GLU A 187 -31. 275 16. ,474 1. 510 1.00 38. 50 A 0

ATOM 2621 N SER A 188 -30. 070 17. ,233 -0. 240 1.00 43. 71 A N

ATOM 2622 CA SER A 188 -30. 182 18. ,632 0. 112 1.00 43. 54 A c

ATOM 2624 CB SER A 188 -28. 834 19. ,108 0. 614 1.00 40. 57 A c

ATOM 2627 OG SER A 188 -27. 876 18. ,837 -0. 377 1.00 38. 62 A 0

ATOM 2629 C SER A 188 -30. 593 19. ,548 -1. 031 1.00 44. 88 A c

ATOM 2630 O SER A 188 -30. 533 20. ,760 -0. 859 1.00 47. 60 A 0

ATOM 2632 N ASN A 189 -31. 023 19. ,003 -2. 171 1.00 47. 37 A N

ATOM 2633 CA ASN A 189 -31. 386 19. ,848 -3. 307 1.00 49. 15 A c

ATOM 2635 CB ASN A 189 -31. 507 19. ,046 -4. 607 1.00 50. 03 A c

ATOM 2638 CG ASN A 189 -31.408 19. ,934 -5. 860 1.00 52. 49 A c

ATOM 2639 ODl ASN A 189 -31. 165 21. ,140 -5. 771 1.00 56. 54 A 0

ATOM 2640 ND2 ASN A 189 -31. 574 19. ,331 -7. 027 1.00 55. 58 A N

ATOM 2643 C ASN A 189 -32. 675 20. ,626 -3. 034 1.00 49. 54 A c

ATOM 2644 O ASN A 189 -33. 777 20. ,087 -3. 183 1.00 45. 35 A 0

ATOM 2646 N ARG A 190 -32. 514 21. ,882 -2. 600 1.00 51. 57 A N

ATOM 2647 CA ARG A 190 -33. 637 22. ,800 -2. 337 1.00 58. 42 A c

ATOM 2649 CB ARG A 190 -34. 354 23. ,157 -3. 653 1.00 62. 87 A c

ATOM 2652 CG ARG A 190 -33. 390 23. ,705 -4. 743 1.00 69. 39 A c

ATOM 2655 CD ARG A 190 -34. 114 24. ,181 -6. 002 1.00 71. 52 A c

ATOM 2658 NE ARG A 190 -35. 117 23. .216 -6. 472 1.00 76. ,40 A N

ATOM 2660 cz ARG A 190 -35. 997 23. .448 -7. 452 1.00 76. 82 A c

ATOM 2661 NHl ARG A 190 -36. 010 24. ,613 -8. 103 1.00 78. ,15 A N

ATOM 2664 NH2 ARG A 190 -36. 878 22. ,504 -7. 789 1.00 77. 18 A N

ATOM 2667 C ARG A 190 -34. 642 22. ,304 -1. 288 1.00 56. ,61 A C

ATOM 2668 O ARG A 190 -35. 744 22. ,826 -1. 184 1.00 56. 87 A 0

ATOM 2670 N ARG A 191 -34. 227 21. ,310 -0. 507 1.00 55. 75 A N

ATOM 2671 CA ARG A 191 -34. 994 20. ,734 0. 578 1.00 56. 83 A C

ATOM 2673 CB ARG A 191 -35. 766 19. ,509 0. 113 1.00 60. 20 A c

ATOM 2676 CG ARG A 191 -37. 079 19, .789 -0. 552 1.00 68. ,48 A c

ATOM 2679 CD ARG A 191 -37. 382 18. .668 -1. 520 1.00 74. ,41 A c

ATOM 2682 NE ARG A 191 -38. 771 18. .636 -1. 965 1.00 80. 80 A N

ATOM 2684 CZ ARG A 191 -39. 217 17, .885 -2. 976 1.00 85. 30 A c

ATOM 2685 NHl ARG A 191 -38. 384 17. .098 -3. 662 1.00 85. 72 A N

ATOM 2688 NH2 ARG A 191 -40. 506 17. ,920 -3. 311 1.00 84. ,71 A N

ATOM 2691 C ARG A 191 -33. 979 20. ,280 1. 600 1.00 50. 61 A C

ATOM 2692 0 ARG A 191 -33. 175 19. ,402 1. 307 1.00 52. 86 A 0

ATOM 2694 N ASP A 192 -34. 005 20, ,835 2. 804 1.00 44. 93 A N

ATOM 2695 CA ASP A 192 -32. 893 20, .603 3. 691 1.00 44. ,37 A C

ATOM 2697 CB ASP A 192 -31. 683 21, .399 3. 140 1.00 43. ,38 A C

ATOM 2700 CG ASP A 192 -30. 338 20, .807 3. ,540 1.00 39. ,39 A C

ATOM 2701 ODl ASP A 192 -30. 299 19, .820 4. 328 1.00 34. ,22 A 0

ATOM 2702 OD2 ASP A 192 -29. 319 21, .365 3. 073 1.00 33. ,45 A 0

ATOM 2703 C ASP A 192 -33. 162 20, .964 5. 152 1.00 40. 62 A c

ATOM 2704 0 ASP A 192 -34. 109 21, .666 5. 476 1.00 37. ,59 A 0

ATOM 2706 N SER A 193 -32. 319 20. .402 6. 006 1.00 41. ,21 A N human fD_Fab

ATOM 2707 CA SER A 193 -32. .040 20. ,884 7. 342 1.00 43. ,42 A C

ATOM 2709 CB SER A 193 -31. .223 19. ,850 8. 110 1.00 43. 78 A C

ATOM 2712 OG SER A 193 -31. .951 19. ,405 9. 206 1.00 48. 79 A 0

ATOM 2714 C SER A 193 -31. 212 22. ,152 7. 219 1.00 47. ,18 A c

ATOM 2715 O SER A 193 -30. 488 22. ,351 6. 246 1.00 47. 31 A 0

ATOM 2717 N CYS A 194 -31. ,274 22. ,991 8. 232 1.00 52. 15 A N

ATOM 2718 CA CYS A 194 -30. 808 24. 336 8. 069 1.00 54. 60 A c

ATOM 2720 CB CYS A 194 -31. 982 25. 123 7. 489 1.00 60. 78 A c

ATOM 2723 SG CYS A 194 -31. 641 26. 188 6. 127 1.00 70. 11 A s

ATOM 2725 C CYS A 194 -30. 359 24. 902 9. 405 1.00 53. 53 A c

ATOM 2726 O CYS A 194 -30. 439 24. 238 10. 427 1.00 53. 31 A 0

ATOM 2728 N LYS A 195 -29. 886 26. 134 9. 385 1.00 54. 56 A N

ATOM 2729 CA LYS A 195 -29. ,495 26. ,839 10. 606 1.00 52. ,11 A c

ATOM 2731 CB LYS A 195 -28. 934 28. ,220 10. 231 1.00 54. ,40 A c

ATOM 2734 CG LYS A 195 -28. 067 28. 886 11. 293 1.00 59. 22 A c

ATOM 2737 CD LYS A 195 -26. ,883 29. 631 10. 646 1.00 64. ,38 A c

ATOM 2740 CE LYS A 195 -25. ,600 28. ,761 10. 519 1.00 70. ,51 A c

ATOM 2743 NZ LYS A 195 -25. ,837 27. 278 10. 407 1.00 73. ,76 A N

ATOM 2747 C LYS A 195 -30. 684 26. 959 11. 575 1.00 46. 04 A c

ATOM 2748 O LYS A 195 -31. 723 27. 520 11. 219 1.00 41. 78 A 0

ATOM 2750 N GLY A 196 -30. ,514 26. 415 12. 783 1.00 41.54 A N

ATOM 2751 CA GLY A 196 -31. ,577 26. ,343 13. 799 1.00 37. 71 A c

ATOM 2754 C GLY A 196 -32. ,331 25. Oil 13. 830 1.00 35. 75 A c

ATOM 2755 O GLY A 196 -33. 190 24. 806 14. 678 1.00 34. 33 A 0

ATOM 2757 N ASP A 197 -32. 026 24. 105 12. 898 1.00 32. 07 A N

ATOM 2758 CA ASP A 197 -32. 585 22. 753 12. 910 1.00 35. 69 A c

ATOM 2760 CB ASP A 197 -32. ,841 22. 229 11.482 1.00 31. ,60 A c

ATOM 2763 CG ASP A 197 -33. ,915 23. ,003 10. 752 1.00 32. ,48 A c

ATOM 2764 ODl ASP A 197 -34. ,882 23. ,449 11. 393 1.00 31. ,77 A 0

ATOM 2765 OD2 ASP A 197 -33. ,807 23. ,171 9. 516 1.00 36. ,89 A 0

ATOM 2766 C ASP A 197 -31. ,660 21. ,774 13. 645 1.00 31. ,88 A c

ATOM 2767 O ASP A 197 -32. ,055 20. ,664 13. 966 1.00 31. ,55 A 0

ATOM 2769 N SER A 198 -30. ,442 22. ,195 13. 926 1.00 31. ,47 A N

ATOM 2770 CA SER A 198 -29. ,480 21. ,368 14. 654 1.00 34. ,60 A c

ATOM 2772 CB SER A 198 -28. 200 22. ,157 14. 920 1.00 33. ,82 A c

ATOM 2775 OG SER A 198 -27. 555 22. ,415 13. 705 1.00 30. 12 A 0

ATOM 2777 C SER A 198 -30. 043 20. 860 15. 973 1.00 34. ,61 A c

ATOM 2778 O SER A 198 -30. 775 21. 556 16. 648 1.00 35. 71 A 0

ATOM 2780 N GLY A 199 -29. 676 19. 642 16. 330 1.00 36. 86 A N

ATOM 2781 CA GLY A 199 -30. 198 19. 010 17. 527 1.00 36. 83 A c

ATOM 2784 C GLY A 199 -31. ,520 18. ,292 17. 327 1.00 34. ,76 A c

ATOM 2785 O GLY A 199 -31. ,869 17. ,434 18. 114 1.00 32. ,66 A 0

ATOM 2787 N GLY A 200 -32. ,244 18. ,649 16. 267 1.00 36. ,94 A N

ATOM 2788 CA GLY A 200 -33. ,531 18. ,056 15. 955 1.00 34. ,99 A C

ATOM 2791 C GLY A 200 -33. ,435 16. ,669 15. 343 1.00 38. ,15 A C

ATOM 2792 O GLY A 200 -32. ,341 16. ,208 14. 967 1.00 38. ,12 A 0

ATOM 2794 N PRO A 201 -34. 593 15. ,995 15. 225 1.00 39. ,66 A N

ATOM 2795 CA PRO A 201 -34. ,711 14. ,602 14. 813 1.00 37. ,30 A c

ATOM 2797 CB PRO A 201 -36. ,037 14. ,184 15. 472 1.00 37. ,28 A c

ATOM 2800 CG PRO A 201 -36. ,851 15. ,403 15. 429 1.00 38. ,55 A c

ATOM 2803 CD PRO A 201 -35. 913 16. ,567 15. 553 1.00 38. ,49 A c

ATOM 2806 C PRO A 201 -34. 786 14. ,341 13. 319 1.00 33. ,30 A c

ATOM 2807 O PRO A 201 -35. 494 15. ,044 12. 623 1.00 31. ,72 A 0

ATOM 2808 N LEU A 202 -34. 037 13. ,337 12. 862 1.00 32. ,10 A N

ATOM 2809 CA LEU A 202 -34. ,246 12. ,659 11. 574 1.00 35, ,20 A c

ATOM 2811 CB LEU A 202 -32. ,935 12. .502 10. 794 1.00 36. ,98 A c

ATOM 2814 CG LEU A 202 -33. ,094 11. .712 9. 476 1.00 34. ,98 A c

ATOM 2816 CDl LEU A 202 -33. 264 12. ,624 8. 305 1.00 32. ,33 A c

ATOM 2820 CD2 LEU A 202 -31. 944 10. .749 9. 233 1.00 36. ,97 A c

ATOM 2824 C LEU A 202 -34. 872 11. ,267 11. 821 1.00 34. ,35 A c

ATOM 2825 O LEU A 202 -34. 243 10. ,359 12. 345 1.00 31. ,53 A 0

ATOM 2827 N VAL A 203 -36. 132 11. ,124 11.443 1.00 38. ,68 A N

ATOM 2828 CA VAL A 203 -36. 957 9. ,985 11. 857 1.00 37. ,25 A c

ATOM 2830 CB VAL A 203 -38. 215 10. ,526 12. 516 1.00 31. ,09 A c

ATOM 2832 CGI VAL A 203 -39. 066 9. ,410 13. 186 1.00 28. ,65 A c

ATOM 2836 CG2 VAL A 203 -37. 810 11. ,589 13. 515 1.00 26. ,17 A c

ATOM 2840 C VAL A 203 -37. 291 9. ,116 10. 644 1.00 38. ,35 A c

ATOM 2841 O VAL A 203 -37. 958 9. ,573 9. 722 1.00 39. .46 A 0 human fD_Fab

ATOM 2843 N CYS A 204 -36. 781 7. 888 10. ,621 1.00 41. ,41 A N

ATOM 2844 CA CYS A 204 -37. 033 6. 970 9. ,499 1.00 45. ,49 A C

ATOM 2846 CB CYS A 204 -35. 731 6. ,464 8. ,864 1.00 41. ,90 A C

ATOM 2849 SG CYS A 204 -34. 428 7. 666 8. ,615 1.00 38. ,41 A S

ATOM 2851 C CYS A 204 -37. 862 5. 761 9. ,951 1.00 48. ,67 A c

ATOM 2852 O CYS A 204 -37. 390 4. 926 10. 729 1.00 48. 60 A 0

ATOM 2854 N GLY A 205 -39. 085 5. 664 9. 438 1.00 50. ,07 A N

ATOM 2855 CA GLY A 205 -39. 995 4. 579 9. 792 1.00 51. ,61 A c

ATOM 2858 C GLY A 205 -40. 463 4. 645 11. 237 1.00 53. ,34 A c

ATOM 2859 O GLY A 205 -40. 537 3. 625 11.923 1.00 51. ,94 A 0

ATOM 2861 N GLY A 206 -40. 769 5. 859 11. ,696 1.00 53. ,41 A N

ATOM 2862 CA GLY A 206 -41. 195 6. 112 13. ,073 1.00 51. ,89 A C

ATOM 2865 C GLY A 206 -40. 139 6. 091 14. ,179 1.00 50. ,95 A C

ATOM 2866 O GLY A 206 -40. 430 6. 463 15. 312 1.00 48. ,96 A 0

ATOM 2868 N VAL A 207 -38. 924 5. 645 13. 863 1.00 50. ,42 A N

ATOM 2869 CA VAL A 207 -37. 830 5. 585 14. 831 1.00 48. ,00 A C

ATOM 2871 CB VAL A 207 -37. 115 4. 230 14. 746 1.00 49. ,45 A C

ATOM 2873 CGl VAL A 207 -35. 983 4. ,147 15. ,770 1.00 48. ,25 A c

ATOM 2877 CG2 VAL A 207 -38. 112 3. 090 14. ,931 1.00 48. ,40 A c

ATOM 2881 C VAL A 207 -36. 802 6. 705 14. ,567 1.00 45. ,98 A c

ATOM 2882 O VAL A 207 -36. 492 7. 003 13. ,417 1.00 43. ,93 A 0

ATOM 2884 N LEU A 208 -36. 286 7. 312 15. 639 1.00 42. ,48 A N

ATOM 2885 CA LEU A 208 -35. 193 8. 282 15. ,543 1.00 41. ,09 A c

ATOM 2887 CB LEU A 208 -34. 898 8. 940 16. 903 1.00 36.84 A c

ATOM 2890 CG LEU A 208 -33. 789 10. 013 16. 885 1.00 39. ,04 A c

ATOM 2892 CDl LEU A 208 -34. 271 11. 330 16. ,198 1.00 36. ,60 A c

ATOM 2896 CD2 LEU A 208 -33. 234 10. 272 18. ,295 1.00 34. ,74 A c

ATOM 2900 C LEU A 208 -33. 931 7. 591 15. ,033 1.00 44. ,06 A c

ATOM 2901 O LEU A 208 -33. 485 6. 595 15. ,612 1.00 46. ,66 A 0

ATOM 2903 N GLU A 209 -33. 375 8. 102 13. 935 1.00 41. ,53 A N

ATOM 2904 CA GLU A 209 -32. 152 7. 548 13. 363 1.00 39. ,44 A C

ATOM 2906 CB GLU A 209 -32. 346 7. 198 11. ,881 1.00 38. ,56 A c

ATOM 2909 CG GLU A 209 -33. 163 5. 946 11. ,586 1.00 42. ,84 A c

ATOM 2912 CD GLU A 209 -32. 522 4. 631 12. ,019 1.00 44. ,34 A c

ATOM 2913 OEl GLU A 209 -31. 282 4. ,574 12. ,145 1.00 48. ,36 A 0

ATOM 2914 OE2 GLU A 209 -33. 271 3. 633 12. ,210 1.00 44. ,49 A 0

ATOM 2915 C GLU A 209 -30. 976 8. 528 13. ,482 1.00 39. ,58 A c

ATOM 2916 O GLU A 209 -29. 826 8. 114 13. 608 1.00 37. ,68 A 0

ATOM 2918 N GLY A 210 -31. 276 9. 821 13. 405 1.00 38. ,87 A N

ATOM 2919 CA GLY A 210 -30. 271 10. 845 13. 323 1.00 38. ,51 A c

ATOM 2922 C GLY A 210 -30. 618 12. 119 14. ,066 1.00 35. ,24 A c

ATOM 2923 O GLY A 210 -31. 762 12. ,411 14. ,277 1.00 35. ,69 A 0

ATOM 2925 N VAL A 211 -29. 591 12. 850 14. ,485 1.00 36. ,83 A N

ATOM 2926 CA VAL A 211 -29. 738 14. 167 15. ,092 1.00 35. .93 A c

ATOM 2928 CB VAL A 211 -29. 159 14. 166 16. ,528 1.00 30. ,98 A c

ATOM 2930 CGl VAL A 211 -29. 313 15. 515 17. ,230 1.00 34. .41 A c

ATOM 2934 CG2 VAL A 211 -29. 865 13. 065 17. ,341 1.00 29. ,17 A c

ATOM 2938 C VAL A 211 -29. 059 15. 128 14. ,115 1.00 34. ,50 A c

ATOM 2939 O VAL A 211 -27. 938 14. 872 13. ,659 1.00 30. ,56 A 0

ATOM 2941 N VAL A 212 -29. 796 16. ,158 13. ,694 1.00 36. ,07 A N

ATOM 2942 CA VAL A 212 -29. 264 17. ,107 12. ,744 1.00 41. ,08 A C

ATOM 2944 CB VAL A 212 -30. 205 18. ,312 12. .440 1.00 35. .30 A C

ATOM 2946 CGl VAL A 212 -29. 568 19. 216 11. .399 1.00 31. ,10 A c

ATOM 2950 CG2 VAL A 212 -31. 548 17. 872 11. ,957 1.00 33. ,45 A c

ATOM 2954 C VAL A 212 -27. 978 17. 639 13. ,353 1.00 46.31 A c

ATOM 2955 O VAL A 212 -27. 971 18. ,184 14. ,467 1.00 43. ,56 A 0

ATOM 2957 N THR A 213 -26. 872 17. 432 12. ,659 1.00 55. ,28 A N

ATOM 2958 CA THR A 213 -25. 604 17. ,950 13. ,157 1.00 61. .80 A c

ATOM 2960 CB THR A 213 -24. 357 17. ,104 12, ,720 1.00 66, .03 A c

ATOM 2962 OGl THR A 213 -23. 198 17. ,571 13. ,424 1.00 68. .49 A 0

ATOM 2964 CG2 THR A 213 -24. 111 17. ,170 11. ,235 1.00 67. ,10 A c

ATOM 2968 C THR A 213 -25. 603 19. ,416 12. ,750 1.00 68. ,25 A c

ATOM 2969 O THR A 213 -26. 278 20. ,210 13. ,374 1.00 73. ,71 A 0

ATOM 2971 N SER A 214 -24. 865 19. ,775 11. ,718 1.00 72. ,25 A N

ATOM 2972 CA SER A 214 -24. 910 21. ,101 11. ,074 1.00 76. ,36 A c

ATOM 2974 CB SER A 214 -26. 159 21. ,951 11. .364 1.00 77, ,22 A c

ATOM 2977 OG SER A 214 -26. 521 22. ,704 10. .204 1.00 76, .55 A 0

ATOM 2979 C SER A 214 -23. 541 21. 788 11. ,288 1.00 80, ,23 A c human fD_Fab

ATOM 2980 0 SER A 214 -22. 495 21. ,111 11.171 1.00 82. ,33 A 0

ATOM 2982 N GLY A 215 -23. 532 23. ,083 11. 604 1.00 77, ,85 A N

ATOM 2983 CA GLY A 215 -22. 313 23. ,871 11.585 1.00 76. ,95 A C

ATOM 2986 C GLY A 215 -22. 575 25. ,050 10. 689 1.00 74. ,98 A C

ATOM 2987 0 GLY A 215 -23. 632 25. ,666 10. 767 1.00 77. ,19 A 0

ATOM 2989 N SER A 216 -21.625 25. ,358 9. 823 1.00 72. ,84 A N

ATOM 2990 CA SER A 216 -21. ,774 26. ,485 8. 932 1.00 70. ,60 A C

ATOM 2992 CB SER A 216 -20. 643 27. ,462 9. 189 1.00 72. ,77 A C

ATOM 2995 OG SER A 216 -20. 768 27. ,955 10. 513 1.00 73. ,33 A 0

ATOM 2997 C SER A 216 -21.851 26. ,007 7. 481 1.00 68. ,64 A C

ATOM 2998 0 SER A 216 -21.386 26. ,678 6. 556 1.00 69. ,42 A 0

ATOM 3000 N ARG A 217 -22. 468 24. ,839 7. 315 1.00 65. ,04 A N

ATOM 3001 CA ARG A 217 -22. 796 24. ,281 6. Oil 1.00 63. ,03 A c

ATOM 3003 CB ARG A 217 -23. 265 22. ,835 6. 176 1.00 60. ,33 A c

ATOM 3006 CG ARG A 217 -23. 578 22. ,123 4. 875 1.00 58. ,26 A c

ATOM 3009 CD ARG A 217 -24. 149 20. ,754 5. 154 1.00 56. ,30 A c

ATOM 3012 NE ARG A 217 -25. 409 20. ,830 5. 895 1.00 48. ,69 A N

ATOM 3014 CZ ARG A 217 -26. 602 20. ,992 5. 344 1.00 47. ,40 A c

ATOM 3015 NHl ARG A 217 -26. 741 21. ,090 4. 029 1.00 48. ,72 A N

ATOM 3018 NH2 ARG A 217 -27. 668 21. ,058 6. 111 1.00 51. ,24 A N

ATOM 3021 C ARG A 217 -23. 923 25. ,080 5. 380 1.00 60. ,55 A C

ATOM 3022 0 ARG A 217 -24. 923 25. ,370 6. 034 1.00 55. ,93 A 0

ATOM 3024 N VAL A 218 -23. 762 25. ,420 4. 107 1.00 61. 08 A N

ATOM 3025 CA VAL A 218 -24. 795 26. ,129 3. 360 1.00 59. ,99 A C

ATOM 3027 CB VAL A 218 -24. 305 26. ,522 1. 937 1.00 60.01 A C

ATOM 3029 CGI VAL A 218 -24. 019 25. ,275 1. 078 1.00 58. ,46 A c

ATOM 3033 CG2 VAL A 218 -25. 326 27. ,448 1. 243 1.00 62. 88 A c

ATOM 3037 C VAL A 218 -26. 053 25. ,267 3. 246 1.00 59. ,59 A c

ATOM 3038 0 VAL A 218 -25. 961 24. ,042 3. 159 1.00 60. ,26 A 0

ATOM 3040 N CYS A 219 -27. 216 25. 917 3. 228 1.00 54. ,32 A N

ATOM 3041 CA CYS A 219 -28. 502 25. 231 3. 218 1.00 53, ,49 A c

ATOM 3043 CB CYS A 219 -29. 517 26. Oil 4. 074 1.00 56. ,74 A c

ATOM 3046 SG CYS A 219 -30. 969 25. ,078 4. 575 1.00 59. 89 A s

ATOM 3048 C CYS A 219 -29. 072 25. ,063 1. 806 1.00 49. ,47 A c

ATOM 3049 0 CYS A 219 -28. 979 25. .958 0. 991 1.00 48. ,44 A 0

ATOM 3051 N GLY A 220 -29. 667 23. ,911 1. 531 1.00 44. ,95 A N

ATOM 3052 CA GLY A 220 -30. 422 23. ,705 0. 313 1.00 47. .94 A c

ATOM 3055 C GLY A 220 -29. 632 23. ,594 -0. 981 1.00 48. ,48 A c

ATOM 3056 0 GLY A 220 -30. 206 23. ,747 -2. 064 1.00 47. ,22 A 0

ATOM 3058 N ASN A 221 -28. 332 23. ,330 -0. 874 1.00 49. ,31 A N

ATOM 3059 CA ASN A 221 -27. 482 23. ,155 -2. 038 1.00 49. ,62 A c

ATOM 3061 CB ASN A 221 -26. 178 23. ,946 -1. 898 1.00 52. ,96 A c

ATOM 3064 CG ASN A 221 -25. 343 23. .950 -3. 189 1.00 53, ,85 A c

ATOM 3065 ODl ASN A 221 -25. 696 23. ,300 -4. 182 1.00 53, .83 A 0

ATOM 3066 ND2 ASN A 221 -24. 224 24. ,681 -3. 168 1.00 52, .88 A N

ATOM 3069 C ASN A 221 -27. 211 21. .680 -2. 226 1.00 49, .03 A c

ATOM 3070 0 ASN A 221 -26. 660 21.026 -1. 337 1.00 49, .09 A 0

ATOM 3072 N ARG A 222 -27. 597 21. ,161 -3. 389 1.00 51, .03 A N

ATOM 3073 CA ARG A 222 -27. 375 19. ,748 -3. 739 1.00 49, ,73 A C

ATOM 3075 CB ARG A 222 -27. 799 19. ,471 -5. 183 1.00 54. .93 A C

ATOM 3078 CG ARG A 222 -26. 844 20. ,005 -6. 260 1.00 55. .59 A C

ATOM 3081 CD ARG A 222 -27. 209 19. ,455 -7. 625 1.00 57. .22 A C

ATOM 3084 NE ARG A 222 -26. 570 20. .200 -8. 709 1.00 61. .33 A N

ATOM 3086 CZ ARG A 222 -25. 264 20, .171 -8. 995 1.00 64, ,40 A C

ATOM 3087 NHl ARG A 222 -24. 410 19. .445 -8. 279 1.00 63. .49 A N

ATOM 3090 NH2 ARG A 222 -24. 799 20. ,884 -10. 007 1.00 65, ,72 A N

ATOM 3093 C ARG A 222 -25. 930 19. ,263 -3. 572 1.00 44, ,96 A C

ATOM 3094 0 ARG A 222 -25. 704 18. ,078 -3. 359 1.00 41, .28 A 0

ATOM 3096 N LYS A 223 -24. 974 20. ,183 -3. 702 1.00 41, .97 A N

ATOM 3097 CA LYS A 223 -23. 552 19. ,908 -3. 541 1.00 41. .05 A C

ATOM 3099 CB LYS A 223 -22. 706 21. ,045 -4. 164 1.00 42, .51 A C

ATOM 3102 CG LYS A 223 -22. 873 21. .289 -5. ,679 1.00 38, .48 A C

ATOM 3105 CD LYS A 223 -21. 812 22, ,279 -6. ,187 1.00 38, .52 A c

ATOM 3108 CE LYS A 223 -21. 817 22, .392 -7. ,729 1.00 39, .66 A c

ATOM 3111 NZ LYS A 223 -20. 778 23, .351 -8. 239 1.00 31, .27 A N

ATOM 3115 C LYS A 223 -23. 090 19, ,773 -2. 090 1.00 41, .57 A C

ATOM 3116 0 LYS A 223 -21. 961 19, .352 -1. 837 1.00 42, .59 A 0

ATOM 3118 N LYS A 224 -23. 914 20. ,171 -1. ,130 1.00 39, .53 A N human fD_Fab

ATOM 3119 CA LYS A 224 -23. ,594 19. ,923 0. ,279 1.00 38. 37 A C

ATOM 3121 CB LYS A 224 -23. ,275 21.230 0. ,998 1.00 39. ,87 A C

ATOM 3124 CG LYS A 224 -22. ,019 21. .954 0. ,501 1.00 42. ,15 A C

ATOM 3127 CD LYS A 224 -20. ,746 21. ,203 0. 889 1.00 47. ,01 A c

ATOM 3130 CE LYS A 224 -19. 520 21. ,751 0. 188 1.00 44. 59 A c

ATOM 3133 NZ LYS A 224 -19. 520 21. ,332 -1. 218 1.00 49. 17 A N

ATOM 3137 C LYS A 224 -24. 733 19. ,182 1. 001 1.00 36. 72 A c

ATOM 3138 O LYS A 224 -25. 578 19. 800 1. 619 1.00 36. 89 A 0

ATOM 3140 N PRO A 225 -24. 756 17. ,842 0. 919 1.00 35. 57 A N

ATOM 3141 CA PRO A 225 -25. 828 17. ,053 1. 562 1.00 36. 68 A C

ATOM 3143 CB PRO A 225 -25. 419 15. ,606 1. 273 1.00 34. 34 A C

ATOM 3146 CG PRO A 225 -24. 568 15. ,691 0. 053 1.00 35. 92 A c

ATOM 3149 CD PRO A 225 -23. 791 16. ,974 0. 218 1.00 34. 59 A c

ATOM 3152 C PRO A 225 -25. 929 17. ,288 3. ,070 1.00 37. 33 A c

ATOM 3153 O PRO A 225 -24. 963 17. ,701 3. 703 1.00 37. ,24 A 0

ATOM 3154 N GLY A 226 -27. 104 17. ,034 3. 638 1.00 37. 58 A N

ATOM 3155 CA GLY A 226 -27. 316 17. 258 5. 072 1.00 35. 74 A c

ATOM 3158 C GLY A 226 -26. 542 16. 209 5. 844 1.00 31.37 A c

ATOM 3159 O GLY A 226 -26. 355 15. ,108 5. 348 1.00 29. 50 A 0

ATOM 3161 N ILE A 227 -26. 080 16. ,563 7. 040 1.00 34. 03 A N

ATOM 3162 CA ILE A 227 -25. 290 15. 656 7. 898 1.00 34. 66 A c

ATOM 3164 CB ILE A 227 -23. 858 16. ,182 8. 179 1.00 31. 38 A c

ATOM 3166 CGI ILE A 227 -23. 041 16. ,309 6. 882 1.00 36. 53 A c

ATOM 3169 CDl ILE A 227 -21. 734 17. ,106 7. 024 1.00 34. 20 A c

ATOM 3173 CG2 ILE A 227 -23. 120 15. ,230 9. 096 1.00 30. 98 A c

ATOM 3177 C ILE A 227 -26. 039 15. ,419 9. 217 1.00 31. 71 A c

ATOM 3178 O ILE A 227 -26. 524 16. ,360 9. 845 1.00 27. ,85 A 0

ATOM 3180 N TYR A 228 -26. 154 14. ,148 9. 604 1.00 32. 75 A N

ATOM 3181 CA TYR A 228 -26. 949 13. ,742 10. 776 1.00 33. 62 A c

ATOM 3183 CB TYR A 228 -28. 261 13. ,099 10. 324 1.00 28. 33 A c

ATOM 3186 CG TYR A 228 -29. 019 13. ,985 9. 382 1.00 26. 44 A c

ATOM 3187 CDl TYR A 228 -29. 969 14. ,855 9. 858 1.00 27. 41 A c

ATOM 3189 CEl TYR A 228 -30. 666 15. ,681 9. 009 1.00 29. 99 A c

ATOM 3191 cz TYR A 228 -30. 396 15. ,669 7. 649 1.00 27. 71 A c

ATOM 3192 OH TYR A 228 -31. 105 16. ,531 6. 820 1.00 30. 43 A 0

ATOM 3194 CE2 TYR A 228 -29. 457 14. ,812 7. 139 1.00 24. 44 A c

ATOM 3196 CD2 TYR A 228 -28. 763 13. ,966 8. 010 1.00 29. 02 A c

ATOM 3198 C TYR A 228 -26. 151 12. ,756 11. 592 1.00 31. 85 A c

ATOM 3199 O TYR A 228 -25. 534 11. ,874 11. 028 1.00 32. 20 A 0

ATOM 3201 N THR A 229 -26. 122 12. ,914 12. 908 1.00 35. ,77 A N

ATOM 3202 CA THR A 229 -25. 367 11. ,979 13. ,751 1.00 36. ,18 A c

ATOM 3204 CB THR A 229 -24. 896 12. ,608 15. ,088 1.00 33. 69 A c

ATOM 3206 OGl THR A 229 -24. 142 13. ,783 14. ,809 1.00 37. ,56 A 0

ATOM 3208 CG2 THR A 229 -23. 983 11. ,631 15. ,888 1.00 31. ,81 A c

ATOM 3212 C THR A 229 -26. 247 10. ,755 14. ,001 1.00 36. ,64 A c

ATOM 3213 O THR A 229 -27. 390 10. ,884 14. ,417 1.00 33. ,42 A 0

ATOM 3215 N ARG A 230 -25. 690 9. ,576 13. 739 1.00 38. 08 A N

ATOM 3216 CA ARG A 230 -26. 407 8. ,307 13. ,868 1.00 38. ,54 A c

ATOM 3218 CB ARG A 230 -25. 671 7. ,194 13. 090 1.00 39. ,30 A c

ATOM 3221 CG ARG A 230 -25. 571 7. ,462 11. 610 1.00 38. ,36 A c

ATOM 3224 CD ARG A 230 -24. 893 6. ,366 10. 827 1.00 42. ,84 A c

ATOM 3227 NE ARG A 230 -25. 570 5. ,089 11.009 1.00 47. ,76 A N

ATOM 3229 CZ ARG A 230 -25. 166 4. ,103 11. 813 1.00 50. ,09 A c

ATOM 3230 NHl ARG A 230 -24. 053 4. ,215 12. ,533 1.00 50. ,28 A N

ATOM 3233 NH2 ARG A 230 -25. 899 2. ,997 11. ,902 1.00 46. ,72 A N

ATOM 3236 C ARG A 230 -26. 533 7. ,907 15. ,318 1.00 38. ,45 A C

ATOM 3237 O ARG A 230 -25. 548 7. ,568 15. ,951 1.00 42. ,21 A 0

ATOM 3239 N VAL A 231 -27. 748 7. ,921 15. ,850 1.00 42. ,31 A N

ATOM 3240 CA VAL A 231 -27. 961 7. ,597 17. ,261 1.00 39. ,18 A C

ATOM 3242 CB VAL A 231 -29. 419 7. ,801 17. ,703 1.00 37. ,87 A c

ATOM 3244 CGl VAL A 231 -29. 767 9. ,242 17. ,607 1.00 36. ,63 A c

ATOM 3248 CG2 VAL A 231 -30. 410 6. ,912 16. ,889 1.00 35. ,10 A c

ATOM 3252 C VAL A 231 -27. 521 6. ,194 17. ,610 1.00 40. ,30 A c

ATOM 3253 O VAL A 231 -27. 029 5. ,970 18. ,704 1.00 44. ,42 A 0

ATOM 3255 N ALA A 232 -27. 682 5. ,263 16. ,671 1.00 44. ,13 A N

ATOM 3256 CA ALA A 232 -27. 288 3. ,848 16. ,856 1.00 41. ,46 A c

ATOM 3258 CB ALA A 232 -27. 575 3. ,062 15. ,604 1.00 37. ,15 A c

ATOM 3262 C ALA A 232 -25. 829 3. ,668 17. ,239 1.00 41. ,45 A c human fD_Fab

ATOM 3263 O ALA A 232 -25. 487 2. ,771 18. 026 1.00 42. ,52 A 0

ATOM 3265 N SER A 233 -24. 985 4. 514 16. 652 1.00 41, ,76 A N

ATOM 3266 CA SER A 233 -23. 571 4. ,560 16. 942 1.00 39. ,20 A C

ATOM 3268 CB SER A 233 -22. 888 5. ,626 16. 072 1.00 39. .85 A C

ATOM 3271 OG ASER A 233 -22. 493 5. ,089 14. 827 0.70 42. ,98 A 0

ATOM 3272 OG 1 BSER A 233 -22. 500 5. ,086 14. 824 0.30 41. ,27 A 0

ATOM 3275 C SER A 233 -23. 280 4. ,863 18. 395 1.00 39. ,20 A c

ATOM 3276 O SER A 233 -22. 242 4. ,462 18. 888 1.00 39. ,30 A 0

ATOM 3278 N TYR A 234 -24. 174 5. 590 19. 071 1.00 41. 68 A N

ATOM 3279 CA TYR A 234 -23. 928 6. ,058 20. 440 1.00 42. ,49 A c

ATOM 3281 CB TYR A 234 -24. 027 7. ,580 20. 483 1.00 38. ,75 A c

ATOM 3284 CG TYR A 234 -22. 948 8. ,229 19. 653 1.00 37. ,97 A c

ATOM 3285 CDl TYR A 234 -21. 762 8. 632 20. 226 1.00 35. ,58 A c

ATOM 3287 CEl TYR A 234 -20. 760 9. ,196 19. 458 1.00 38. ,65 A c

ATOM 3289 cz TYR A 234 -20. 937 9. ,343 18. 112 1.00 35. ,16 A c

ATOM 3290 OH TYR A 234 -19. 961 9. ,930 17. 365 1.00 37. .63 A 0

ATOM 3292 CE2 TYR A 234 -22. 106 8. ,947 17. 514 1.00 38. ,19 A c

ATOM 3294 CD2 TYR A 234 -23. 104 8. ,393 18. 278 1.00 37. ,30 A c

ATOM 3296 C TYR A 234 -24. 860 5. ,408 21. 469 1.00 44. ,63 A c

ATOM 3297 0 TYR A 234 -25. 100 5. 958 22. 554 1.00 41. ,33 A 0

ATOM 3299 N ALA A 235 -25. 332 4. 206 21. 128 1.00 46. ,09 A N

ATOM 3300 CA ALA A 235 -26. 299 3. ,467 21. 944 1.00 45. ,75 A c

ATOM 3302 CB ALA A 235 -26. 686 2. ,138 21. 282 1.00 41. ,82 A c

ATOM 3306 C ALA A 235 -25. 826 3. ,247 23. 370 1.00 46. ,58 A c

ATOM 3307 0 ALA A 235 -26. 569 3. 522 24. 295 1.00 47. ,29 A 0

ATOM 3309 N ALA A 236 -24. 596 2. 781 23. 549 1.00 47. ,60 A N

ATOM 3310 CA ALA A 236 -24. 039 2. ,544 24. 890 1.00 50. ,24 A c

ATOM 3312 CB ALA A 236 -22. 669 1. 834 24. 792 1.00 53. ,25 A c

ATOM 3316 C ALA A 236 -23. 928 3. 821 25. 734 1.00 52. ,61 A c

ATOM 3317 0 ALA A 236 -24. 230 3. ,798 26. 935 1.00 58. ,24 A 0

ATOM 3319 N TRP A 237 -23. 518 4. ,927 25. 111 1.00 50. ,90 A N

ATOM 3320 CA TRP A 237 -23. 377 6. 201 25. 817 1.00 51.68 A C

ATOM 3322 CB TRP A 237 -22. 646 7. ,256 24. 973 1.00 48. 68 A C

ATOM 3325 CG TRP A 237 -22. 720 8. 604 25. 629 1.00 48. ,35 A c

ATOM 3326 CDl TRP A 237 -22. 084 8. ,991 26. 777 1.00 47. ,65 A c

ATOM 3328 NEl TRP A 237 -22. 431 10. ,278 27. 098 1.00 46. ,89 A N

ATOM 3330 CE2 TRP A 237 -23. 302 10. ,755 26. 154 1.00 47. ,30 A c

ATOM 3331 CD2 TRP A 237 -23. 524 9. ,719 25. 222 1.00 48. ,43 A c

ATOM 3332 CE3 TRP A 237 -24. 401 9. 952 24. 148 1.00 47. ,93 A c

ATOM 3334 CZ3 TRP A 237 -25. 025 11. ,198 24. 046 1.00 45. ,85 A c

ATOM 3336 CH2 TRP A 237 -24. 778 12. ,206 24. 977 1.00 46. ,52 A c

ATOM 3338 CZ2 TRP A 237 -23. 925 12. Oil 26. 042 1.00 48. ,32 A c

ATOM 3340 C TRP A 237 -24. 720 6. ,770 26. 268 1.00 53. ,93 A c

ATOM 3341 0 TRP A 237 -24. 859 7. ,240 27. 400 1.00 56. ,83 A 0

ATOM 3343 N ILE A 238 -25. 703 6. ,746 25. 378 1.00 52. ,57 A N

ATOM 3344 CA ILE A 238 -27. 044 7. ,233 25. 723 1.00 53. ,70 A c

ATOM 3346 CB ILE A 238 -28. 006 7. ,237 24. 497 1.00 50. .89 A c

ATOM 3348 CGI ILE A 238 -27. 462 8. ,169 23. 387 1.00 49. .63 A c

ATOM 3351 CDl ILE A 238 -28. 198 8. ,064 22. 057 1.00 46. .38 A c

ATOM 3355 CG2 ILE A 238 -29. 423 7. ,651 24. 914 1.00 44. ,00 A c

ATOM 3359 C ILE A 238 -27. 641 6. ,398 26. 871 1.00 56. ,57 A c

ATOM 3360 0 ILE A 238 -28. 297 6. ,938 27. 761 1.00 57. ,87 A 0

ATOM 3362 N ASP A 239 -27. 399 5. ,088 26. 854 1.00 58. ,74 A N

ATOM 3363 CA ASP A 239 -27. 866 4. ,203 27. 939 1.00 57. ,43 A c

ATOM 3365 CB ASP A 239 -27. 583 2. ,722 27. 643 1.00 54. ,42 A c

ATOM 3368 CG ASP A 239 -28. 531 2. ,128 26. 598 1.00 49. ,99 A c

ATOM 3369 ODl ASP A 239 -29. 586 2. ,749 26. 328 1.00 43. ,10 A 0

ATOM 3370 OD2 ASP A 239 -28. 213 1. ,038 26. 046 1.00 42, .96 A 0

ATOM 3371 C ASP A 239 -27. 236 4. ,570 29. 270 1.00 58, .18 A c

ATOM 3372 0 ASP A 239 -27. 939 4. .619 30. 275 1.00 59. .46 A 0

ATOM 3374 N SER A 240 -25. 928 4. ,840 29. 275 1.00 58. .65 A N

ATOM 3375 CA SER A 240 -25. 216 5. ,192 30. 512 1.00 59. .40 A c

ATOM 3377 CB SER A 240 -23. 707 5. ,339 30. 249 1.00 61. .80 A c

ATOM 3380 OG ASER A 240 -23. 402 6. ,541 29. 555 0.60 62. .77 A 0

ATOM 3381 OG BSER A 240 -23. 406 6. ,539 29. 552 0.40 62. .28 A 0

ATOM 3384 C SER A 240 -25. 767 6. ,460 31. 189 1.00 60. .44 A c

ATOM 3385 0 SER A 240 -25. 845 6. ,529 32. 411 1.00 63. .16 A 0

ATOM 3387 N VAL A 241 -26. 144 7. ,446 30. 380 1.00 60. ,46 A N human fD_Fab

ATOM 3388 CA VAL A 241 -26 651 8 740 30 852 1.00 59 39 A C

ATOM 3390 CB VAL A 241 -26 525 9 796 29 727 1.00 56 72 A C

ATOM 3392 CGl VAL A 241 -27 171 11 138 30 130 1.00 53 63 A C

ATOM 3396 CG2 VAL A 241 -25 065 9. 952 29 335 1.00 47 46 A c

ATOM 3400 C VAL A 241 -28 109 8. 665 31 307 1.00 60 05 A c

ATOM 3401 O VAL A 241 -28 490 9. 284 32 296 1.00 61 32 A 0

ATOM 3403 N LEU A 242 -28 918 7 905 30 578 1.00 61 37 A N

ATOM 3404 CA LEU A 242 -30 321 7 693 30 947 1.00 63 20 A C

ATOM 3406 CB LEU A 242 -31 144 7 160 29 764 1.00 60 26 A c

ATOM 3409 CG LEU A 242 -31 872 8 207 28 915 1.00 58 16 A c

ATOM 3411 CDl LEU A 242 -30 956 9 364 28 562 1.00 57 28 A c

ATOM 3415 CD2 LEU A 242 -32 443 7 567 27 659 1.00 58 08 A c

ATOM 3419 C LEU A 242 -30 480 6 760 32 148 1.00 67 42 A c

ATOM 3420 O LEU A 242 -31 363 6. 979 32 980 1.00 69 30 A 0

ATOM 3422 N ALA A 243 -29 631 5. 729 32 233 1.00 68 87 A N

ATOM 3423 CA ALA A 243 -29 675 4. 752 33 331 1.00 68 18 A c

ATOM 3425 CB ALA A 243 -28 502 3. 776 33 218 1.00 68 91 A c

ATOM 3429 C ALA A 243 -29 661 5 432 34 705 1.00 71 16 A c

ATOM 3430 O ALA A 243 -30 444 5 091 35 608 1.00 69 67 A 0

ATOM 3432 OXT ALA A 243 -28 867 6 352 34 932 1.00 73 66 A 0

ATOM 3433 N ASP L 1 -22 592 16 088 -20 360 1.00 57 56 L N

ATOM 3434 CA ASP L 1 -21 209 16 210 -19 846 1.00 45 88 L c

ATOM 3436 CB ASP L 1 -20 262 15 267 -20 623 1.00 54 14 L c

ATOM 3439 CG ASP L 1 -20 474 13 776 -20 290 1.00 57 25 L c

ATOM 3440 ODl ASP L 1 -21 535 13 410 -19 738 1.00 58 37 L 0

ATOM 3441 OD2 ASP L 1 -19 564 12. 962 -20 593 1.00 56 76 L 0

ATOM 3442 C ASP L 1 -20 697 17. 650 -19 951 1.00 44 64 L c

ATOM 3443 O ASP L 1 -20 755 18. 254 -21 010 1.00 48 78 L 0

ATOM 3447 N ILE L 2 -20 171 18 170 -18 842 1.00 43 07 L N

ATOM 3448 CA ILE L 2 -19 539 19 495 -18 801 1.00 41 00 L c

ATOM 3450 CB ILE L 2 -19 343 19 991 -17 367 1.00 39 37 L c

ATOM 3452 CGl ILE L 2 -20 706 20 022 -16 643 1.00 39 23 L c

ATOM 3455 CDl ILE L 2 -20 634 20 428 -15 185 1.00 36 61 L c

ATOM 3459 CG2 ILE L 2 -18 682 21 375 -17 379 1.00 38 53 L c

ATOM 3463 C ILE L 2 -18 200 19 486 -19 542 1.00 42 94 L c

ATOM 3464 O ILE L 2 -17 422 18 538 -19 441 1.00 46 44 L 0

ATOM 3466 N GLN L 3 -17 967 20. 546 -20 308 1.00 46 56 L N

ATOM 3467 CA GLN L 3 -16 784 20. 698 -21 145 1.00 45 19 L c

ATOM 3469 CB GLN L 3 -17 177 21. 206 -22 539 1.00 51 70 L c

ATOM 3472 CG GLN L 3 -18 171 20 305 -23 287 1.00 59 10 L c

ATOM 3475 CD GLN L 3 -17 707 18 842 -23 371 1.00 67 82 L c

ATOM 3476 OEl GLN L 3 -16 535 18 558 -23 660 1.00 71 54 L 0

ATOM 3477 NE2 GLN L 3 -18 629 17 910 -23 110 1.00 68 81 L N

ATOM 3480 C GLN L 3 -15 826 21.676 -20 486 1.00 42 02 L c

ATOM 3481 0 GLN L 3 -16 247 22 597 -19 792 1.00 41 16 L 0

ATOM 3483 N VAL L 4 -14 534 21 453 -20 684 1.00 40 93 L N

ATOM 3484 CA VAL L 4 -13 507 22 347 -20 154 1.00 41 75 L C

ATOM 3486 CB VAL L 4 -12 748 21 722 -18 991 1.00 39 04 L C

ATOM 3488 CGl VAL L 4 -11 795 22 763 -18 372 1.00 44 23 L C

ATOM 3492 CG2 VAL L 4 -13 727 21 221 -17 968 1.00 42 02 L C

ATOM 3496 C VAL L 4 -12 534 22 672 -21 282 1.00 39 98 L c

ATOM 3497 0 VAL L 4 -12 242 21 826 -22 113 1.00 40 20 L 0

ATOM 3499 N THR L 5 -12 056 23 899 -21 327 1.00 39 58 L N

ATOM 3500 CA THR L 5 -11 073 24 291 -22 330 1.00 39 96 L c

ATOM 3502 CB THR L 5 -11 609 25 438 -23 259 1.00 50 26 L c

ATOM 3504 OGl THR L 5 -12 712 24 954 -24 042 1.00 56 19 L 0

ATOM 3506 CG2 THR L 5 -10 505 25 977 -24 205 1.00 48 86 L c

ATOM 3510 C THR L 5 -9 859 24 787 -21 555 1.00 34 14 L c

ATOM 3511 0 THR L 5 -9 957 25 801 -20 895 1.00 29 11 L 0

ATOM 3513 N GLN L 6 -8 752 24 040 -21 608 1.00 33 25 L N

ATOM 3514 CA GLN L 6 -7 505 24 424 -20 938 1.00 33 93 L c

ATOM 3516 CB GLN L 6 -6 764 23 186 -20 412 1.00 35 26 L c

ATOM 3519 CG GLN L 6 -5 488 23 503 -19 626 1.00 32 60 L c

ATOM 3522 CD GLN L 6 -5 083 22 410 -18 666 1.00 28 59 L c

ATOM 3523 OEl GLN L 6 -5 807 21 451 -18 455 1.00 27 24 L 0

ATOM 3524 NE2 GLN L 6 -3 926 22 567 -18 056 1.00 29 05 L N

ATOM 3527 C GLN L 6 -6 590 25 182 -21 904 1.00 34 90 L c

ATOM 3528 0 GLN L 6 -6 553 24 875 -23 090 1.00 34 73 L 0 human fD_Fab

ATOM 3530 N SER L 7 -5. 854 26 158 -21 377 1.00 33 37 L N

ATOM 3531 CA SER L 7 -4 909 26 932 -22 153 1.00 32 07 L C

ATOM 3533 CB SER L 7 -5 587 28 101 -22 858 1.00 37 89 L C

ATOM 3536 OG SER L 7 -4 607 28 957 -23 447 1.00 42 88 L 0

ATOM 3538 C SER L 7 -3 808 27 476 -21 262 1.00 31 47 L C

ATOM 3539 O SER L 7 -4 044 27 790 -20 101 1.00 34 89 L 0

ATOM 3541 N PRO L 8 -2. 591 27 601 -21 801 1.00 31 53 L N

ATOM 3542 CA PRO L 8 -2. 189 27 203 -23 160 1.00 33 48 L c

ATOM 3544 CB PRO L 8 -0. 902 28 030 -23 399 1.00 29 04 L C

ATOM 3547 CG PRO L 8 -0 344 28 295 -22 054 1.00 28 39 L c

ATOM 3550 CD PRO L 8 -1 475 28 186 -21 035 1.00 29 12 L C

ATOM 3553 C PRO L 8 -1 921 25 707 -23 267 1.00 32 37 L c

ATOM 3554 O PRO L 8 -1. 996 24 987 -22 281 1.00 36 84 L 0

ATOM 3555 N SER L 9 -1. 583 25 255 -24 460 1.00 35 49 L N

ATOM 3556 CA SER L 9 -1. 230 23 870 -24 703 1.00 33 20 L c

ATOM 3558 CB SER L 9 -1. 394 23 574 -26 197 1.00 33 39 L C

ATOM 3561 OG SER L 9 -0. 838 22 315 -26 515 1.00 44 21 L 0

ATOM 3563 C SER L 9 0 201 23 554 -24 214 1.00 31 41 L C

ATOM 3564 O SER L 9 0 484 22 454 -23 736 1.00 29 89 L 0

ATOM 3566 N SER L 10 1. 106 24 515 -24 335 1.00 34 17 L N

ATOM 3567 CA SER L 10 2. 430 24 387 -23 744 1.00 31 49 L c

ATOM 3569 CB SER L 10 3. 350 23 487 -24 589 1.00 39 84 L C

ATOM 3572 OG SER L 10 3. 429 23 960 -25 914 1.00 40 04 L 0

ATOM 3574 C SER L 10 3. 040 25 740 -23 593 1.00 34 42 L C

ATOM 3575 O SER L 10 2. 610 26 695 -24 214 1.00 38 55 L 0

ATOM 3577 N LEU L 11 4. 035 25 812 -22 727 1.00 37 17 L N

ATOM 3578 CA LEU L 11 4. 730 27 058 -22 437 1.00 34 61 L C

ATOM 3580 CB LEU L 11 3. 926 27 928 -21 450 1.00 34 95 L C

ATOM 3583 CG LEU L 11 3. 748 27 465 -19 994 1.00 36 48 L c

ATOM 3585 CDl LEU L 11 5. 023 27 683 -19 177 1.00 29 27 L C

ATOM 3589 CD2 LEU L 11 2. 570 28 188 -19 324 1.00 35 14 L c

ATOM 3593 C LEU L 11 6. 091 26 752 -21 851 1.00 33 86 L C

ATOM 3594 0 LEU L 11 6. 323 25 678 -21 240 1.00 29 81 L 0

ATOM 3596 N SER L 12 6. 969 27 736 -22 010 1.00 36 77 L N

ATOM 3597 CA SER L 12 8. 336 27 653 -21 544 1.00 37 94 L c

ATOM 3599 CB SER L 12 9. 282 27 505 -22 739 1.00 42 27 L C

ATOM 3602 OG SER L 12 10. 544 27 050 -22 310 1.00 47 65 L 0

ATOM 3604 C SER L 12 8. 627 28 922 -20 765 1.00 36 43 L c

ATOM 3605 0 SER L 12 8. 244 30 000 -21 195 1.00 38 70 L 0

ATOM 3607 N ALA L 13 9. 265 28 782 -19 606 1.00 35 68 L N

ATOM 3608 CA ALA L 13 9. 603 29 916 -18 764 1.00 35 42 L c

ATOM 3610 CB ALA L 13 8. 422 30 254 -17 872 1.00 37 92 L c

ATOM 3614 C ALA L 13 10. 835 29 627 -17 923 1.00 36 26 L c

ATOM 3615 0 ALA L 13 11. 260 28 483 -17 811 1.00 40 43 L 0

ATOM 3617 N SER L 14 11. 385 30 667 -17 300 1.00 38 14 L N

ATOM 3618 CA SER L 14 12. 621 30 565 -16 529 1.00 37 65 L c

ATOM 3620 CB SER L 14 13. 439 31 842 -16 700 1.00 38 52 L c

ATOM 3623 OG SER L 14 14. 026 31 909 -17 985 1.00 40 88 L 0

ATOM 3625 C SER L 14 12. 386 30 318 -15 037 1.00 38 57 L c

ATOM 3626 0 SER L 14 11. 336 30 665 -14 486 1.00 36 87 L 0

ATOM 3628 N VAL L 15 13. 384 29 722 -14 385 1.00 37 78 L N

ATOM 3629 CA VAL L 15 13. 362 29 538 -12 945 1.00 37 46 L c

ATOM 3631 CB VAL L 15 14. 694 28 923 -12 456 1.00 40 00 L c

ATOM 3633 CGI VAL L 15 14. 937 29 191 -10 965 1.00 37 02 L c

ATOM 3637 CG2 VAL L 15 14. 716 27 427 -12 780 1.00 35 60 L c

ATOM 3641 C VAL L 15 13. 114 30 895 -12 298 1.00 38 64 L c

ATOM 3642 0 VAL L 15 13. 811 31 868 -12 582 1.00 41 97 L 0

ATOM 3644 N GLY L 16 12. 097 30 963 -11 458 1.00 39 96 L N

ATOM 3645 CA GLY L 16 11. 749 32 207 -10 773 1.00 39 00 L c

ATOM 3648 C GLY L 16 10. 553 32 932 -11 362 1.00 37 74 L c

ATOM 3649 0 GLY L 16 9. 971 33 787 -10 707 1.00 40 10 L 0

ATOM 3651 N ASP L 17 10. 190 32 589 -12 598 1.00 40 74 L N

ATOM 3652 CA ASP L 17 9. 059 33 206 -13 299 1.00 40 30 L c

ATOM 3654 CB ASP L 17 9. 064 32 809 -14 784 1.00 37 61 L c

ATOM 3657 CG ASP L 17 10. 136 33 520 -15 601 1.00 43 36 L c

ATOM 3658 ODl ASP L 17 10. 818 34 426 -15 066 1.00 42 18 L 0

ATOM 3659 OD2 ASP L 17 10. 280 33 163 -16 806 1.00 44 96 L 0

ATOM 3660 C ASP L 17 7. 699 32 779 -12 732 1.00 44 02 L c human fD_Fab

ATOM 3661 O ASP L 17 7 582 31 793 -11 998 1.00 43 56 L 0

ATOM 3663 N ARG L 18 6 670 33 532 -13 113 1.00 40 48 L N

ATOM 3664 CA ARG L 18 5 316 33 210 -12 776 1.00 39 14 L C

ATOM 3666 CB ARG L 18 4 525 34. 466 -12 421 1.00 38 17 L C

ATOM 3669 CG ARG L 18 3 037 34. 192 -12 143 1.00 43 04 L C

ATOM 3672 CD ARG L 18 2 311 35. 404 -11 563 1.00 44 99 L c

ATOM 3675 NE ARG L 18 2 983 35 941 -10 375 1.00 47 48 L N

ATOM 3677 CZ ARG L 18 2 575 37 019 -9 716 1.00 49 83 L c

ATOM 3678 NHl ARG L 18 1 490 37 680 -10 125 1.00 50 58 L N

ATOM 3681 NH2 ARG L 18 3 252 37 444 -8 652 1.00 47 68 L N

ATOM 3684 C ARG L 18 4 646 32 538 -13 964 1.00 42 17 L C

ATOM 3685 O ARG L 18 4 630 33 097 -15 066 1.00 43 32 L 0

ATOM 3687 N VAL L 19 4 058 31. 364 -13 712 1.00 42 08 L N

ATOM 3688 CA VAL L 19 3 330 30. 599 -14 719 1.00 37 74 L C

ATOM 3690 CB VAL L 19 3 759 29. 113 -14 700 1.00 36 98 L C

ATOM 3692 CGI VAL L 19 2 902 28. 288 -15 642 1.00 33 86 L c

ATOM 3696 CG2 VAL L 19 5 223 29. 010 -15 042 1.00 34 01 L c

ATOM 3700 C VAL L 19 1 842 30 691 -14 475 1.00 37 21 L c

ATOM 3701 O VAL L 19 1 383 30 518 -13 355 1.00 43 02 L 0

ATOM 3703 N THR L 20 1 091 30 963 -15 540 1.00 37 92 L N

ATOM 3704 CA THR L 20 -0 344 31 154 -15 467 1.00 36 43 L c

ATOM 3706 CB THR L 20 -0 741 32 621 -15 683 1.00 37 95 L c

ATOM 3708 OGl THR L 20 -0 106 33 432 -14 685 1.00 43 67 L 0

ATOM 3710 CG2 THR L 20 -2 268 32. 788 -15 540 1.00 36 16 L c

ATOM 3714 C THR L 20 -1 040 30. 281 -16 499 1.00 38 23 L c

ATOM 3715 O THR L 20 -0 800 30. 424 -17 698 1.00 38 80 L 0

ATOM 3717 N ILE L 21 -1 902 29. 383 -16 012 1.00 36 71 L N

ATOM 3718 CA ILE L 21 -2 605 28. 389 -16 826 1.00 35 70 L c

ATOM 3720 CB ILE L 21 -2 188 26 945 -16 407 1.00 36 28 L c

ATOM 3722 CGI ILE L 21 -0 726 26 683 -16 743 1.00 38 72 L c

ATOM 3725 CD1 ILE L 21 -0 175 25 395 -16 108 1.00 44 91 L c

ATOM 3729 CG2 ILE L 21 -3 056 25 876 -17 097 1.00 38 52 L c

ATOM 3733 C ILE L 21 -4 083 28 549 -16 543 1.00 33 24 L c

ATOM 3734 O ILE L 21 -4 429 28 711 -15 382 1.00 32 42 L 0

ATOM 3736 N THR L 22 -4 941 28. 530 -17 572 1.00 32 33 L N

ATOM 3737 CA THR L 22 -6 361 28. 754 -17 381 1.00 39 90 L c

ATOM 3739 CB THR L 22 -6 839 30. 055 -18 096 1.00 41 23 L c

ATOM 3741 OGl THR L 22 -6 564 29. 970 -19 499 1.00 44 62 L 0

ATOM 3743 CG2 THR L 22 -6 157 31. 258 -17 515 1.00 37 62 L c

ATOM 3747 C THR L 22 -7 272 27 594 -17 848 1.00 40 85 L c

ATOM 3748 O THR L 22 -6 965 26 883 -18 799 1.00 41 14 L 0

ATOM 3750 N CYS L 23 -8 410 27 431 -17 175 1.00 43 42 L N

ATOM 3751 CA CYS L 23 -9 481 26 547 -17 648 1.00 42 68 L c

ATOM 3753 CB CYS L 23 -9 571 25 251 -16 831 1.00 48 31 L c

ATOM 3756 SG CYS L 23 -8 377 24 025 -17 418 1.00 59 32 L s

ATOM 3758 C CYS L 23 -10 802 27 301 -17 622 1.00 39 36 L c

ATOM 3759 O CYS L 23 -11 076 28 042 -16 680 1.00 39 09 L 0

ATOM 3761 N ILE L 24 -11 586 27 121 -18 683 1.00 39 78 L N

ATOM 3762 CA ILE L 24 -12 894 27 748 -18 840 1.00 42 12 L c

ATOM 3764 CB ILE L 24 -12 931 28 701 -20 044 1.00 42 07 L c

ATOM 3766 CGI ILE L 24 -11 931 29 852 -19 844 1.00 44 53 L c

ATOM 3769 CDl ILE L 24 -11 500 30 472 -21 128 1.00 46 85 L c

ATOM 3773 CG2 ILE L 24 -14 345 29 252 -20 246 1.00 39 80 L c

ATOM 3777 C ILE L 24 -13 943 26 680 -19 071 1.00 43 42 L c

ATOM 3778 O ILE L 24 -13 843 25 905 -20 032 1.00 41 92 L 0

ATOM 3780 N THR L 25 -14 954 26 642 -18 200 1.00 44 73 L N

ATOM 3781 CA THR L 25 -15 986 25 602 -18 258 1.00 40 41 L c

ATOM 3783 CB THR L 25 -16 429 25 165 -16 854 1.00 43 51 L c

ATOM 3785 OGl THR L 25 -16 842 26 313 -16 090 1.00 46 66 L 0

ATOM 3787 CG2 THR L 25 -15 281 24 449 -16 129 1.00 40 24 L c

ATOM 3791 C THR L 25 -17 190 26 055 -19 071 1.00 36 98 L c

ATOM 3792 O THR L 25 -17 424 27 248 -19 245 1.00 35 24 L 0

ATOM 3794 N SER L 26 -17 944 25 087 -19 590 1.00 41 47 L N

ATOM 3795 CA SER L 26 -19 097 25 383 -20 442 1.00 43 97 L c

ATOM 3797 CB SER L 26 -19 428 24 193 -21 350 1.00 44 55 L c

ATOM 3800 OG SER L 26 -19 453 22 975 -20 620 1.00 48 76 L 0

ATOM 3802 C SER L 26 -20 335 25 821 -19 627 1.00 47 07 L c

ATOM 3803 O SER L 26 -21 315 26.301 -20 208 1.00 49 17 L 0 human fD_Fab

ATOM 3805 N THR L 27 -20. 274 25. ,675 -18. 296 1.00 47. 68 L N

ATOM 3806 CA THR L 27 -21. ,361 26. ,068 -17. 396 1.00 45. 58 L C

ATOM 3808 CB THR L 27 -22. 271 24. ,859 -17. 048 1.00 53. 79 L C

ATOM 3810 OGl THR L 27 -22. 655 24. ,180 -18. 252 1.00 62. 51 L 0

ATOM 3812 CG2 THR L 27 -23. 522 25. ,299 -16. 298 1.00 52. 78 L C

ATOM 3816 C THR L 27 -20. 774 26. ,600 -16. 100 1.00 45. 19 L C

ATOM 3817 O THR L 27 -19. 625 26. ,324 -15. 774 1.00 48. 40 L 0

ATOM 3819 N ASP L 28 -21. 573 27. ,362 -15. 366 1.00 47. 89 L N

ATOM 3820 CA ASP L 28 -21. 197 27. ,803 -14. 047 1.00 47. 67 L C

ATOM 3822 CB ASP L 28 -22. 234 28. ,779 -13. 488 1.00 48. 98 L c

ATOM 3825 CG ASP L 28 -21. 759 29. ,452 -12. 234 1.00 52. 20 L c

ATOM 3826 ODl ASP L 28 -21. 576 30. ,682 -12. 249 1.00 62. 24 L 0

ATOM 3827 OD2 ASP L 28 -21. 521 28. ,749 -11. 238 1.00 57. 96 L 0

ATOM 3828 C ASP L 28 -21. 064 26. ,570 -13. 151 1.00 46. 01 L c

ATOM 3829 O ASP L 28 -21. 991 25. ,781 -13. 033 1.00 47. 36 L 0

ATOM 3831 N ILE L 29 -19. 898 26. ,442 -12. 530 1.00 42. 48 L N

ATOM 3832 CA ILE L 29 -19. 467 25. 252 -11. 801 1.00 42. 20 L c

ATOM 3834 CB ILE L 29 -18. 288 24. 659 -12. 622 1.00 43. 38 L c

ATOM 3836 CGI ILE L 29 -18. 856 23. ,657 -13. 608 1.00 45. 55 L c

ATOM 3839 CDl ILE L 29 -17. 888 23. 211 -14. 614 1.00 51. 65 L c

ATOM 3843 CG2 ILE L 29 -17. 167 24. ,099 -11. 774 1.00 45. 69 L c

ATOM 3847 C ILE L 29 -19. 082 25. ,631 -10. 375 1.00 39. 62 L c

ATOM 3848 O ILE L 29 -18. 412 24. ,880 -9. 673 1.00 39. ,37 L 0

ATOM 3850 N ASP L 30 -19. 534 26. 809 -9. 953 1.00 39. 45 L N

ATOM 3851 CA ASP L 30 -19. 160 27. ,379 -8. 657 1.00 41. 59 L c

ATOM 3853 CB ASP L 30 -19. 957 26. ,701 -7. 518 1.00 42. 61 L c

ATOM 3856 CG ASP L 30 -21. 462 26. ,754 -7. 749 1.00 43. 50 L c

ATOM 3857 ODl ASP L 30 -21. 994 27. ,876 -7. 928 1.00 48. 50 L 0

ATOM 3858 OD2 ASP L 30 -22. 116 25. ,679 -7. 775 1.00 46. 86 L 0

ATOM 3859 C ASP L 30 -17. 638 27. ,360 -8. 439 1.00 40. 32 L c

ATOM 3860 O ASP L 30 -16. 899 28. ,061 -9. 133 1.00 41. 74 L 0

ATOM 3862 N ASP L 31 -17. 186 26. ,556 -7. 486 1.00 43. 55 L N

ATOM 3863 CA ASP L 31 -15. 829 26. ,562 -6. 964 1.00 40. 84 L c

ATOM 3865 CB ASP L 31 -15. 983 26. ,632 -5. 434 1.00 48. 06 L c

ATOM 3868 CG ASP L 31 -15. 072 27. ,626 -4. 781 1.00 59. 00 L c

ATOM 3869 ODl ASP L 31 -14. 134 28. ,127 -5. 439 1.00 69. 59 L 0

ATOM 3870 OD2 ASP L 31 -15. 305 27. ,909 -3. 581 1.00 60. 87 L 0

ATOM 3871 C ASP L 31 -15. 127 25. ,231 -7. 280 1.00 36. 47 L c

ATOM 3872 O ASP L 31 -14. 001 24. ,989 -6. 859 1.00 32. 93 L 0

ATOM 3874 N ASP L 32 -15. 821 24. ,360 -7. 988 1.00 34. 59 L N

ATOM 3875 CA ASP L 32 -15. 487 22. ,955 -8. 025 1.00 38. 68 L c

ATOM 3877 CB ASP L 32 -16. 795 22. ,143 -8. 094 1.00 42. 00 L c

ATOM 3880 CG ASP L 32 -17. 620 22. ,315 -6. 841 1.00 42. 45 L c

ATOM 3881 ODl ASP L 32 -17. 052 22. ,133 -5. 748 1.00 38. 19 L 0

ATOM 3882 OD2 ASP L 32 -18. 807 22. ,677 -6. 934 1.00 49. 29 L 0

ATOM 3883 C ASP L 32 -14. 511 22. ,605 -9. ,161 1.00 37. 40 L c

ATOM 3884 O ASP L 32 -14. 778 21. ,699 -9. ,979 1.00 35. 32 L 0

ATOM 3886 N MET L 33 -13. 383 23. ,322 -9. ,157 1.00 34. 11 L N

ATOM 3887 CA MET L 33 -12. 293 23. ,097 -10. ,053 1.00 33. 37 L c

ATOM 3889 CB MET L 33 -11.921 24. ,402 -10. ,748 1.00 37. 31 L c

ATOM 3892 CG MET L 33 -10. 847 24. 290 -11. ,815 1.00 36. 01 L c

ATOM 3895 SD MET L 33 -11. 288 23. ,157 -13. 133 1.00 42. 53 L S

ATOM 3896 CE MET L 33 -12. 617 24. ,023 -13. 995 1.00 33. 25 L c

ATOM 3900 C MET L 33 -11. 079 22. ,542 -9. 276 1.00 35. 49 L c

ATOM 3901 O MET L 33 -10. 786 22. ,976 -8. ,170 1.00 34. 68 L 0

ATOM 3903 N ASN L 34 -10. 383 21. ,580 -9. ,893 1.00 37. ,27 L N

ATOM 3904 CA ASN L 34 -9. 191 20. ,962 -9. ,327 1.00 34. ,76 L c

ATOM 3906 CB ASN L 34 -9. 408 19. ,476 -9. ,023 1.00 38. ,89 L c

ATOM 3909 CG ASN L 34 -10. 697 19. ,222 -8. ,307 1.00 36. ,18 L c

ATOM 3910 ODl ASN L 34 -10. 725 19. ,050 -7. ,079 1.00 38. 80 L 0

ATOM 3911 ND2 ASN L 34 -11. 795 19. ,236 -9. ,061 1.00 40. 53 L N

ATOM 3914 C ASN L 34 -8. 067 21.055 -10. ,317 1.00 31.86 L c

ATOM 3915 O ASN L 34 -8. 311 21. ,160 -11.521 1.00 33. ,02 L 0

ATOM 3917 N TRP L 35 -6. 844 20. ,994 -9. ,799 1.00 30. ,55 L N

ATOM 3918 CA TRP L 35 -5. 654 20. ,996 -10. ,615 1.00 30. 36 L c

ATOM 3920 CB TRP L 35 -4. 918 22. ,340 -10. 490 1.00 35. ,36 L c

ATOM 3923 CG TRP L 35 -5. 705 23. ,475 -11.053 1.00 37. ,91 L c

ATOM 3924 CDl TRP L 35 -6. 598 24. ,281 -10. 380 1.00 36. 63 L c human fD_Fab

ATOM 3926 NEl TRP L 35 -7. 120 25. 220 -11. 235 1.00 34. ,78 L N

ATOM 3928 CE2 TRP L 35 -6. ,592 25. 033 -12. 487 1.00 36. ,78 L C

ATOM 3929 CD2 TRP L 35 -5. ,692 23. 944 -12. 412 1.00 40. ,85 L C

ATOM 3930 CE3 TRP L 35 -4. 995 23. 564 -13. 564 1.00 39. ,55 L c

ATOM 3932 CZ3 TRP L 35 -5. ,219 24. 270 -14. 743 1.00 35. ,57 L c

ATOM 3934 CH2 TRP L 35 -6. 135 25. 337 -14. 782 1.00 38. ,18 L c

ATOM 3936 CZ2 TRP L 35 -6. 824 25. 731 -13. 673 1.00 36. ,85 L c

ATOM 3938 C TRP L 35 -4. 745 19. 829 -10. 228 1.00 30. ,20 L c

ATOM 3939 O TRP L 35 -4. ,562 19. 516 -9. 031 1.00 28. ,74 L 0

ATOM 3941 N TYR L 36 -4. 187 19. 187 -11. 253 1.00 34. ,39 L N

ATOM 3942 CA TYR L 36 -3. ,289 18. 039 -11.098 1.00 32. ,30 L c

ATOM 3944 CB TYR L 36 -3. 879 16. 791 -11. 750 1.00 31. ,28 L c

ATOM 3947 CG TYR L 36 -5. 057 16. 148 -11. 042 1.00 33. ,73 L c

ATOM 3948 CDl TYR L 36 -4. 890 15. 009 -10. 246 1.00 35. ,52 L c

ATOM 3950 CEl TYR L 36 -5. 989 14. 408 -9. 584 1.00 31. ,56 L c

ATOM 3952 CZ TYR L 36 -7. 248 14. 946 -9. 745 1.00 35. ,40 L c

ATOM 3953 OH TYR L 36 -8. 316 14. 356 -9. 129 1.00 33. 56 L 0

ATOM 3955 CE2 TYR L 36 -7. 441 16. 097 -10. 516 1.00 34. 23 L c

ATOM 3957 CD 2 TYR L 36 -6. 351 16. 689 -11. 154 1.00 37. 76 L c

ATOM 3959 C TYR L 36 -1. 963 18. 329 -11. 783 1.00 34. ,21 L c

ATOM 3960 O TYR L 36 -1. 902 19. 138 -12. 726 1.00 33. 60 L 0

ATOM 3962 N GLN L 37 -0. 918 17. 666 -11. 284 1.00 32. 97 L N

ATOM 3963 CA GLN L 37 0. 413 17. 681 -11. 838 1.00 35. 58 L c

ATOM 3965 CB GLN L 37 1. 407 18. 115 -10. 758 1.00 35. ,59 L c

ATOM 3968 CG GLN L 37 2. 849 18. 235 -11. 201 1.00 35. ,46 L c

ATOM 3971 CD GLN L 37 3. 732 18. 717 -10. 081 1.00 38. ,66 L c

ATOM 3972 OEl GLN L 37 3. 723 18. 126 -9. 001 1.00 45. ,41 L 0

ATOM 3973 NE2 GLN L 37 4. 481 19. 810 -10. 311 1.00 32. ,32 L N

ATOM 3976 C GLN L 37 0. 765 16. 262 -12. 250 1.00 36. 66 L c

ATOM 3977 O GLN L 37 0. 560 15. 333 -11. 474 1.00 36. ,15 L 0

ATOM 3979 N GLN L 38 1. 295 16. 083 -13. 457 1.00 39. ,24 L N

ATOM 3980 CA GLN L 38 1. 865 14. 782 -13. 833 1.00 40. ,38 L c

ATOM 3982 CB GLN L 38 0. 968 14. 037 -14. 824 1.00 39. ,50 L c

ATOM 3985 CG GLN L 38 1. 452 12. 636 -15. 131 1.00 39. ,67 L c

ATOM 3988 CD GLN L 38 0. 467 11. 834 -15. 919 1.00 40. ,77 L c

ATOM 3989 OEl GLN L 38 -0. 187 12. 357 -16. 817 1.00 47. ,43 L 0

ATOM 3990 NE2 GLN L 38 0. 362 10. 537 -15. 609 1.00 39. ,83 L N

ATOM 3993 C GLN L 38 3. 270 14. 936 -14. 395 1.00 40. ,58 L C

ATOM 3994 O GLN L 38 3. 475 15. 587 -15. 416 1.00 41.61 L 0

ATOM 3996 N LYS L 39 4. 238 14. 334 -13. 716 1.00 45. ,50 L N

ATOM 3997 CA LYS L 39 5. 620 14. 337 -14. 176 1.00 49. ,63 L C

ATOM 3999 CB LYS L 39 6. 586 14. 373 -12. 985 1.00 46. ,97 L C

ATOM 4002 CG LYS L 39 6. 413 15. 646 -12. 147 1.00 47. ,44 L C

ATOM 4005 CD LYS L 39 7. 365 15. 721 -10. 964 1.00 50. 26 L c

ATOM 4008 CE LYS L 39 6. 790 16. 591 -9. 846 1.00 50. ,76 L c

ATOM 4011 NZ LYS L 39 7. 808 17. 101 -8. 866 1.00 50. ,65 L N

ATOM 4015 C LYS L 39 5. 834 13. 138 -15. 086 1.00 55. ,03 L C

ATOM 4016 O LYS L 39 5. 045 12. 191 -15. 040 1.00 56. 18 L 0

ATOM 4018 N PRO L 40 6. 862 13. 200 -15. 960 1.00 62. 10 L N

ATOM 4019 CA PRO L 40 7. 178 12. 181 -16. 959 1.00 62. ,84 L C

ATOM 4021 CB PRO L 40 8. 717 12. 174 -16. 935 1.00 67. 78 L C

ATOM 4024 CG PRO L 40 9. 099 13. 618 -16. 530 1.00 68. ,06 L C

ATOM 4027 CD PRO L 40 7. 828 14. 314 -16. 074 1.00 65. ,12 L C

ATOM 4030 C PRO L 40 6. 601 10. 773 -16. 730 1.00 64. ,80 L c

ATOM 4031 O PRO L 40 5. 681 10. 362 -17. 456 1.00 67. ,75 L 0

ATOM 4032 N GLY L 41 7. 138 10. 041 -15. 754 1.00 60. ,58 L N

ATOM 4033 CA GLY L 41 6. 728 8. 654 -15. 514 1.00 61.09 L c

ATOM 4036 C GLY L 41 6. 087 8. 459 -14. 147 1.00 63. ,15 L c

ATOM 4037 O GLY L 41 6. 525 7. 588 -13. 368 1.00 62. ,69 L 0

ATOM 4039 N LYS L 42 5. 062 9. 266 -13. 835 1.00 59. ,76 L N

ATOM 4040 CA LYS L 42 4. 415 9. 193 -12. 508 1.00 54. ,12 L c

ATOM 4042 CB LYS L 42 4. 995 10. 203 -11. 480 1.00 62. ,46 L c

ATOM 4045 CG LYS L 42 6. 084 11. 162 -11. 962 1.00 67. ,58 L c

ATOM 4048 CD LYS L 42 7. 514 10. 576 -11. 906 1.00 69. ,45 L c

ATOM 4051 CE LYS L 42 8. 471 11. 203 -12. 972 1.00 68. ,53 L c

ATOM 4054 NZ LYS L 42 9. 482 12. 194 -12. 469 1.00 67. ,12 L N

ATOM 4058 C LYS L 42 2. 899 9. 264 -12. ,542 1.00 46. ,39 L c

ATOM 4059 O LYS L 42 2. 285 9. 605 -13. 547 1.00 43. ,87 L 0 human fD_Fab

ATOM 4061 N VAL L 43 2. 286 8. ,896 -11. 424 1.00 46. ,96 L N

ATOM 4062 CA VAL L 43 0. 837 9. ,032 -11. 275 1.00 45. ,71 L C

ATOM 4064 CB VAL L 43 0. 262 8. ,169 -10. 064 1.00 49. ,12 L C

ATOM 4066 CGI VAL L 43 0. ,725 6. ,742 -10. 169 1.00 49. ,87 L c

ATOM 4070 CG2 VAL L 43 0. ,659 8. ,754 -8. 700 1.00 43. ,78 L c

ATOM 4074 C VAL L 43 0. 501 10. ,512 -11. 087 1.00 40. ,44 L c

ATOM 4075 O VAL L 43 1. 307 11. ,262 -10. 514 1.00 36. ,39 L 0

ATOM 4077 N PRO L 44 -0. 680 10. ,947 -11. 561 1.00 36. ,93 L N

ATOM 4078 CA PRO L 44 -1. ,073 12. ,340 -11. ,263 1.00 37. ,73 L c

ATOM 4080 CB PRO L 44 -2. ,438 12. .477 -11. ,922 1.00 36. ,90 L c

ATOM 4083 CG PRO L 44 -2. ,413 11.432 -13. ,035 1.00 37. ,84 L c

ATOM 4086 CD PRO L 44 -1. ,656 10. ,276 -12. 424 1.00 35. ,19 L c

ATOM 4089 C PRO L 44 -1. ,147 12. ,692 -9. 769 1.00 33. ,20 L c

ATOM 4090 0 PRO L 44 -1. 457 11. ,857 -8. 935 1.00 31. ,82 L 0

ATOM 4091 N LYS L 45 -0. 837 13. ,934 -9. 459 1.00 36. ,45 L N

ATOM 4092 CA LYS L 45 -0. 835 14, ,452 -8. 093 1.00 35. ,63 L C

ATOM 4094 CB LYS L 45 0. 578 14. ,907 -7. 706 1.00 39. 36 L C

ATOM 4097 CG LYS L 45 0. 733 15. ,753 -6. 435 1.00 39. 89 L c

ATOM 4100 CD LYS L 45 0. 216 15. ,063 -5. 181 1.00 43. 00 L c

ATOM 4103 CE LYS L 45 0. 766 15. ,726 -3. 918 1.00 43. 84 L c

ATOM 4106 NZ LYS L 45 0. 264 15. ,099 -2. 642 1.00 41. 93 L N

ATOM 4110 C LYS L 45 -1. 829 15. ,626 -8. ,049 1.00 33. 34 L C

ATOM 4111 O LYS L 45 -1. 683 16. ,594 -8. 777 1.00 31. ,98 L 0

ATOM 4113 N LEU L 46 -2. 859 15. ,514 -7. 221 1.00 34. 77 L N

ATOM 4114 CA LEU L 46 -3. 788 16. ,641 -7. 005 1.00 32. ,13 L C

ATOM 4116 CB LEU L 46 -5. 018 16. ,182 -6. 242 1.00 34. 33 L c

ATOM 4119 CG LEU L 46 -6. 167 17. ,170 -6. 065 1.00 33. 49 L c

ATOM 4121 CDl LEU L 46 -6. 795 17. ,479 -7. 410 1.00 28. 78 L c

ATOM 4125 CD2 LEU L 46 -7. 185 16, ,607 -5. 114 1.00 28. 04 L c

ATOM 4129 C LEU L 46 -3. 102 17. ,756 -6. 229 1.00 34. 35 L c

ATOM 4130 O LEU L 46 -2. 678 17. ,550 -5. 094 1.00 35. 17 L 0

ATOM 4132 N LEU L 47 -2. 983 18. ,931 -6. 846 1.00 35. 02 L N

ATOM 4133 CA LEU L 47 -2. 338 20. ,080 -6. 199 1.00 34. 75 L c

ATOM 4135 CB LEU L 47 -1. 625 20. ,970 -7. ,235 1.00 37. 30 L c

ATOM 4138 CG LEU L 47 -0. 511 20. ,433 -8. 134 1.00 36. 91 L c

ATOM 4140 CDl LEU L 47 -0. 185 21. ,506 -9. 166 1.00 37. 64 L c

ATOM 4144 CD2 LEU L 47 0. 722 20. ,053 -7. 379 1.00 36. 33 L c

ATOM 4148 C LEU L 47 -3. 366 20. ,943 -5. 449 1.00 34. 71 L c

ATOM 4149 O LEU L 47 -3. 107 21. ,413 -4. 333 1.00 35. 58 L 0

ATOM 4151 N ILE L 48 -4. 513 21. ,166 -6. 095 1.00 34. 25 L N

ATOM 4152 CA ILE L 48 -5. 510 22. ,151 -5. 668 1.00 34. 30 L c

ATOM 4154 CB ILE L 48 -5. 476 23. ,441 -6. 547 1.00 36. 91 L c

ATOM 4156 CGI ILE L 48 -4. 052 24. ,041 -6. 669 1.00 38. 99 L c

ATOM 4159 CDl ILE L 48 -3. 627 24. ,990 -5. 565 1.00 42. 17 L c

ATOM 4163 CG2 ILE L 48 -6. 456 24. ,472 -6. 033 1.00 35. 75 L c

ATOM 4167 C ILE L 48 -6. 890 21. .543 -5. ,842 1.00 36. ,46 L c

ATOM 4168 O ILE L 48 -7. 207 21. .029 -6. 922 1.00 30. ,87 L 0

ATOM 4170 N SER L 49 -7. 719 21. .607 -4. 795 1.00 37. 39 L N

ATOM 4171 CA SER L 49 -9. 112 21.176 -4. ,905 1.00 40. ,10 L c

ATOM 4173 CB SER L 49 -9. 481 20. ,176 -3. 800 1.00 45. ,16 L c

ATOM 4176 OG SER L 49 -8. 959 20. ,537 -2. 534 1.00 46. ,63 L 0

ATOM 4178 C SER L 49 -10. 069 22. ,364 -4. 872 1.00 40. ,45 L c

ATOM 4179 O SER L 49 -9. 681 23. ,500 -4. 605 1.00 40. ,01 L 0

ATOM 4181 N GLY L 50 -11. 334 22. ,082 -5. 137 1.00 47. 40 L N

ATOM 4182 CA GLY L 50 -12. 357 23. ,105 -5. 190 1.00 50. 48 L c

ATOM 4185 C GLY L 50 -12. 186 24. ,122 -4. 084 1.00 57. 17 L c

ATOM 4186 O GLY L 50 -11. 722 23. ,789 -2. 975 1.00 64. 58 L 0

ATOM 4188 N GLY L 51 -12. 541 25. ,370 -4. 375 1.00 57. 23 L N

ATOM 4189 CA GLY L 51 -12. 319 26, .452 -3. ,413 1.00 56. ,70 L c

ATOM 4192 C GLY L 51 -10. 895 26. .977 -3. ,466 1.00 59. 08 L c

ATOM 4193 O GLY L 51 -10. 520 27. .844 -2. ,667 1.00 60. ,69 L 0

ATOM 4195 N ASN L 52 -10. 103 26. ,449 -4. 405 1.00 54. ,23 L N

ATOM 4196 CA ASN L 52 -8. 698 26, ,800 -4. 537 1.00 50. ,30 L c

ATOM 4198 CB ASN L 52 -8. 583 28. .239 -5. 024 1.00 52. ,59 L c

ATOM 4201 CG ASN L 52 -9. 372 28. ,441 -6. ,304 1.00 59. 49 L c

ATOM 4202 ODl ASN L 52 -9. 301 27. ,593 -7. 223 1.00 53. ,16 L 0

ATOM 4203 ND2 ASN L 52 -10. 180 29. ,518 -6. 358 1.00 62. ,40 L N

ATOM 4206 C ASN L 52 -7. 924 26. ,514 -3. 267 1.00 44. 30 L c human fD_Fab

ATOM 4207 O ASN L 52 -7. 099 27. 309 -2. 811 1.00 40. ,03 L 0

ATOM 4209 N THR L 53 -8. 181 25. ,316 -2. 754 1.00 43. ,59 L N

ATOM 4210 CA THR L 53 -7. 552 24. 801 -1. 547 1.00 44. ,07 L C

ATOM 4212 CB THR L 53 -8. 496 23. ,833 -0. 787 1.00 45. 06 L C

ATOM 4214 OGl THR L 53 -9. 653 24. ,553 -0. 360 1.00 46. 82 L 0

ATOM 4216 CG2 THR L 53 -7. 796 23. 228 0. 424 1.00 42. 81 L C

ATOM 4220 C THR L 53 -6. 300 24. ,034 -1. 904 1.00 39. 74 L c

ATOM 4221 O THR L 53 -6. 358 23. 032 -2. 590 1.00 39. 11 L 0

ATOM 4223 N LEU L 54 -5. 172 24. ,524 -1. 419 1.00 41. ,00 L N

ATOM 4224 CA LEU L 54 -3. 916 23. ,833 -1. 544 1.00 41. 76 L c

ATOM 4226 CB LEU L 54 -2. 788 24. 707 -0. 999 1.00 42. ,70 L c

ATOM 4229 CG LEU L 54 -1. 362 24. ,215 -1. 224 1.00 45. ,27 L c

ATOM 4231 CDl LEU L 54 -1. 085 24. 009 -2. 728 1.00 41.65 L c

ATOM 4235 CD2 LEU L 54 -0. 382 25. 199 -0. 574 1.00 41. 94 L c

ATOM 4239 C LEU L 54 -4. 008 22. 503 -0. 784 1.00 45. 21 L c

ATOM 4240 O LEU L 54 -4. 636 22. 416 0. 277 1.00 46. 41 L 0

ATOM 4242 N ARG L 55 -3. 401 21. 461 -1. 349 1.00 46. 12 L N

ATOM 4243 CA ARG L 55 -3. 434 20. 148 -0. 734 1.00 44. 14 L c

ATOM 4245 CB ARG L 55 -3. 618 19. ,062 -1. 801 1.00 43. ,45 L c

ATOM 4248 CG ARG L 55 -5. 003 19. ,057 -2. 400 1.00 41. ,84 L c

ATOM 4251 CD ARG L 55 -5. 962 18. ,453 -1. 404 1.00 45. ,95 L c

ATOM 4254 NE ARG L 55 -7. 311 18. ,290 -1. 917 1.00 47. ,10 L N

ATOM 4256 CZ ARG L 55 -8. 161 17. ,352 -1. 496 1.00 48. ,12 L c

ATOM 4257 NHl ARG L 55 -7. 798 16. 456 -0. 596 1.00 50. ,15 L N

ATOM 4260 NH2 ARG L 55 -9. 375 17. 279 -2. 008 1.00 49. 95 L N

ATOM 4263 C ARG L 55 -2. 183 19. 883 0. 096 1.00 46. 76 L C

ATOM 4264 O ARG L 55 -1. 120 20. ,450 -0. 159 1.00 47. 31 L 0

ATOM 4266 N PRO L 56 -2. 326 19. 033 1. 122 1.00 51. 28 L N

ATOM 4267 CA PRO L 56 -1. 230 18. ,484 1. 884 1.00 50. ,47 L C

ATOM 4269 CB PRO L 56 -1. 796 17. ,142 2. 331 1.00 55. ,09 L C

ATOM 4272 CG PRO L 56 -3. 266 17. ,461 2. 603 1.00 57. 06 L c

ATOM 4275 CD PRO L 56 -3. 627 18. ,589 1. 671 1.00 55. ,38 L c

ATOM 4278 C PRO L 56 0. 051 18. ,235 1. 106 1.00 51. ,45 L c

ATOM 4279 O PRO L 56 0. 066 17. ,421 0. 171 1.00 50. ,11 L 0

ATOM 4280 N GLY L 57 1. 113 18. 936 1. 496 1.00 51. ,39 L N

ATOM 4281 CA GLY L 57 2. 472 18. ,650 1. 013 1.00 49. ,83 L c

ATOM 4284 C GLY L 57 2. 788 19. ,214 -0. 357 1.00 48. 23 L c

ATOM 4285 O GLY L 57 3. 700 18. ,724 -1. 063 1.00 50. ,72 L 0

ATOM 4287 N VAL L 58 2. 007 20. .213 -0. 757 1.00 45. ,82 L N

ATOM 4288 CA VAL L 58 2. 200 20. ,893 -2. 041 1.00 45. ,58 L c

ATOM 4290 CB VAL L 58 0. 863 21.124 -2. 789 1.00 45. ,31 L c

ATOM 4292 CGI VAL L 58 1. 092 21. ,988 -4. 022 1.00 47. ,89 L c

ATOM 4296 CG2 VAL L 58 0. 182 19. ,786 -3. 181 1.00 45. ,27 L c

ATOM 4300 C VAL L 58 2. 816 22. ,246 -1. 724 1.00 43. ,35 L c

ATOM 4301 O VAL L 58 2. 295 22. ,968 -0. 852 1.00 47. ,99 L 0

ATOM 4303 N PRO L 59 3. 901 22. ,626 -2. 420 1.00 42. ,38 L N

ATOM 4304 CA PRO L 59 4. 475 23. ,927 -2. 092 1.00 44. ,55 L c

ATOM 4306 CB PRO L 59 5. 673 24. ,040 -3. 040 1.00 43. ,20 L c

ATOM 4309 CG PRO L 59 5. 957 22. ,692 -3. 469 1.00 45, ,64 L c

ATOM 4312 CD PRO L 59 4. 663 21. ,963 -3. 483 1.00 45. ,82 L c

ATOM 4315 C PRO L 59 3. 500 25. ,094 -2. 308 1.00 47. ,38 L c

ATOM 4316 0 PRO L 59 2. 675 25. ,069 -3. 228 1.00 47. ,35 L 0

ATOM 4317 N SER L 60 3. 614 26. ,101 -1. 445 1.00 49. ,91 L N

ATOM 4318 CA SER L 60 2. 732 27. ,275 -1. 454 1.00 46. ,98 L c

ATOM 4320 CB SER L 60 2. 979 28. 096 -0. 195 1.00 49. ,20 L c

ATOM 4323 OG SER L 60 4. 350 28. 469 -0. 129 1.00 54. ,02 L 0

ATOM 4325 C SER L 60 2. 960 28. ,176 -2. 683 1.00 45. ,00 L c

ATOM 4326 0 SER L 60 2. 218 29. ,132 -2. 901 1.00 41. ,26 L 0

ATOM 4328 N ARG L 61 3. 994 27. ,892 -3. 476 1.00 44. .43 L N

ATOM 4329 CA ARG L 61 4. 144 28. ,592 -4. 755 1.00 40. .58 L C

ATOM 4331 CB ARG L 61 5. 535 28. ,408 -5. 355 1.00 42. .96 L C

ATOM 4334 CG ARG L 61 5. 925 26. ,991 -5. 736 1.00 46. ,79 L c

ATOM 4337 CD ARG L 61 7. 219 26. ,983 -6. 552 1.00 45. ,12 L c

ATOM 4340 NE ARG L 61 7. 616 25, ,626 -6. 881 1.00 45. ,75 L N

ATOM 4342 CZ ARG L 61 8. 457 24. ,878 -6. 170 1.00 52. ,14 L c

ATOM 4343 NHl ARG L 61 9. 028 25. ,337 -5. 056 1.00 54. ,70 L N

ATOM 4346 NH2 ARG L 61 8. 744 23. ,647 -6. 582 1.00 52. ,43 L N

ATOM 4349 C ARG L 61 3. 039 28. ,203 -5. 747 1.00 39. ,79 L C human fD_Fab

ATOM 4350 O ARG L 61 2. 816 28.914 -6. ,712 1.00 38. ,24 L 0

ATOM 4352 N PHE L 62 2. 328 27.099 -5. ,489 1.00 40. ,12 L N

ATOM 4353 CA PHE L 62 1. ,128 26.768 -6. ,255 1.00 36. ,18 L C

ATOM 4355 CB PHE L 62 0. ,958 25.262 -6. ,373 1.00 37. ,77 L C

ATOM 4358 CG PHE L 62 2. ,045 24.594 -7. .188 1.00 39. ,45 L C

ATOM 4359 CDl PHE L 62 1. ,905 24.437 -8, ,562 1.00 36. ,03 L c

ATOM 4361 CEl PHE L 62 2. ,921 23.830 -9. ,311 1.00 37. ,45 L c

ATOM 4363 cz PHE L 62 4. ,083 23.373 -8. ,681 1.00 35. ,57 L c

ATOM 4365 CE2 PHE L 62 4. 225 23.524 -7. ,315 1.00 38. 56 L c

ATOM 4367 CD2 PHE L 62 3. ,218 24.142 -6. ,575 1.00 38. ,05 L c

ATOM 4369 C PHE L 62 -0. ,087 27.408 -5. ,625 1.00 39. 32 L c

ATOM 4370 O PHE L 62 -0. ,219 27.419 -4. ,399 1.00 40. ,99 L 0

ATOM 4372 N SER L 63 -0. ,965 27.963 -6. .469 1.00 39. 68 L N

ATOM 4373 CA SER L 63 -2. ,223 28.573 -6. ,005 1.00 37. ,11 L c

ATOM 4375 CB SER L 63 -1. ,989 30.005 -5. .481 1.00 40. ,67 L c

ATOM 4378 OG SER L 63 -1. ,480 30.871 -6. ,483 1.00 44. ,67 L 0

ATOM 4380 C SER L 63 -3. ,286 28.593 -7. 103 1.00 36. 69 L c

ATOM 4381 O SER L 63 -2. ,974 28.756 -8. 287 1.00 36. 38 L 0

ATOM 4383 N GLY L 64 -4. ,550 28.454 -6. 699 1.00 38. ,64 L N

ATOM 4384 CA GLY L 64 -5. 669 28.532 -7. ,631 1.00 36. ,63 L c

ATOM 4387 C GLY L 64 -6. 551 29.743 -7. ,374 1.00 38. 35 L c

ATOM 4388 O GLY L 64 -6. ,539 30.327 -6. ,277 1.00 38. ,90 L 0

ATOM 4390 N SER L 65 -7. 331 30.124 -8. ,390 1.00 38. ,60 L N

ATOM 4391 CA SER L 65 -8. 243 31.250 -8. ,276 1.00 38. ,42 L c

ATOM 4393 CB SER L 65 -7. 509 32.602 -8. 350 1.00 45. ,55 L c

ATOM 4396 OG SER L 65 -6. 959 32.871 -9. ,635 1.00 45. 69 L 0

ATOM 4398 C SER L 65 -9. 300 31.168 -9. ,354 1.00 41. ,88 L c

ATOM 4399 O SER L 65 -9. 166 30.409 -10. ,326 1.00 38. ,27 L 0

ATOM 4401 N GLY L 66 -10. 375 31.942 -9. ,153 1.00 44. 14 L N

ATOM 4402 CA GLY L 66 -11. ,526 31.932 -10. ,048 1.00 41. ,05 L c

ATOM 4405 C GLY L 66 -12. 698 31.162 -9. ,455 1.00 41. ,71 L c

ATOM 4406 O GLY L 66 -12. ,545 30.353 -8. ,540 1.00 42. ,11 L 0

ATOM 4408 N SER L 67 -13. ,873 31.425 -10. ,018 1.00 42. ,51 L N

ATOM 4409 CA SER L 67 -15. 138 30.913 -9. ,517 1.00 43. ,33 L c

ATOM 4411 CB SER L 67 -15. 559 31.711 -8. ,269 1.00 47. ,74 L c

ATOM 4414 OG SER L 67 -16. 798 31.250 -7. ,751 1.00 55. ,15 L 0

ATOM 4416 C SER L 67 -16. 162 31.074 -10. ,636 1.00 43. ,41 L c

ATOM 4417 O SER L 67 -16. ,076 32.014 -11.414 1.00 48. ,79 L 0

ATOM 4419 N GLY L 68 -17. ,101 30.144 -10. .748 1.00 44. ,16 L N

ATOM 4420 CA GLY L 68 -18. ,105 30.184 -11. ,811 1.00 41. ,67 L c

ATOM 4423 C GLY L 68 -17. ,664 29.436 -13. ,060 1.00 44. 79 L c

ATOM 4424 O GLY L 68 -17. 965 28.243 -13. ,241 1.00 42. 27 L 0

ATOM 4426 N THR L 69 -16. ,951 30.148 -13. ,924 1.00 44. 49 L N

ATOM 4427 CA THR L 69 -16. 613 29.656 -15. ,263 1.00 40. 94 L c

ATOM 4429 CB THR L 69 -17. 494 30.456 -16. ,286 1.00 42. ,07 L c

ATOM 4431 OG1 THR L 69 -18. 538 29.612 -16. ,800 1.00 45. ,57 L 0

ATOM 4433 CG2 THR L 69 -16. ,679 31.028 -17. ,436 1.00 35. ,26 L c

ATOM 4437 C THR L 69 -15. ,115 29.734 -15. ,635 1.00 37. ,03 L c

ATOM 4438 O THR L 69 -14. ,633 28.920 -16. ,426 1.00 39. ,25 L 0

ATOM 4440 N ASP L 70 -14. ,385 30.671 -15. ,030 1.00 35. ,24 L N

ATOM 4441 CA ASP L 70 -13. ,042 31.052 -15. ,467 1.00 36. ,87 L C

ATOM 4443 CB ASP L 70 -13. ,009 32.549 -15. ,830 1.00 36. ,82 L C

ATOM 4446 CG ASP L 70 -13. 711 32.881 -17. ,164 1.00 42. ,53 L C

ATOM 4447 ODl ASP L 70 -14. 362 32.022 -17. ,799 1.00 45. ,02 L 0

ATOM 4448 OD2 ASP L 70 -13. ,604 34.049 -17. .590 1.00 49. ,54 L 0

ATOM 4449 C ASP L 70 -12. 013 30.799 -14. ,379 1.00 36. ,38 L c

ATOM 4450 O ASP L 70 -11. 962 31.530 -13. ,407 1.00 37. ,51 L 0

ATOM 4452 N PHE L 71 -11. 165 29.787 -14. ,559 1.00 38. ,56 L N

ATOM 4453 CA PHE L 71 -10. 246 29.334 -13. ,502 1.00 36. ,26 L c

ATOM 4455 CB PHE L 71 -10. 595 27.905 -13. ,128 1.00 37. ,35 L c

ATOM 4458 CG PHE L 71 -12. 022 27.744 -12. ,685 1.00 39. ,36 L c

ATOM 4459 CDl PHE L 71 -12. 376 27.944 -11. ,366 1.00 41.49 L c

ATOM 4461 CEl PHE L 71 -13. ,679 27.798 -10. .970 1.00 41.70 L c

ATOM 4463 CZ PHE L 71 -14. ,645 27.472 -11. .892 1.00 38. ,74 L c

ATOM 4465 CE2 PHE L 71 -14. ,304 27.288 -13. .201 1.00 35. ,34 L c

ATOM 4467 CD2 PHE L 71 -13. ,009 27.421 -13. .593 1.00 36. ,05 L c

ATOM 4469 C PHE L 71 -8. ,770 29.446 -13. ,875 1.00 35. ,85 L c

ATOM 4470 O PHE L 71 -8. ,412 29.261 -15. ,031 1.00 37. ,78 L 0 human fD _Fab

ATOM 4472 N THR L 72 -7. 930 29. 768 -12. ,888 1.00 33. 41 L N

ATOM 4473 CA THR L 72 -6. 498 29. 977 -13. ,116 1.00 37. 62 L C

ATOM 4475 CB THR L 72 -6. 100 31. 478 -13. ,045 1.00 37. 06 L C

ATOM 4477 OGl THR L 72 -6. 900 32. 233 -13. ,956 1.00 36. 67 L 0

ATOM 4479 CG2 THR L 72 -4. 656 31. 669 -13. ,403 1.00 33. 86 L C

ATOM 4483 C THR L 72 -5. 686 29. 195 -12. ,082 1.00 36. 83 L C

ATOM 4484 O THR L 72 -6. 071 29. 159 -10.914 1.00 37. 82 L 0

ATOM 4486 N LEU L 73 -4. 615 28. 535 -12. ,549 1.00 33. 33 L N

ATOM 4487 CA LEU L 73 -3. 558 27. 972 -11.714 1.00 34. 88 L C

ATOM 4489 CB LEU L 73 -3. 243 26. 547 -12. ,140 1.00 37. 22 L C

ATOM 4492 CG LEU L 73 -2. 116 25. 800 -11. ,422 1.00 36. 88 L c

ATOM 4494 CDl LEU L 73 -2. 586 25. 278 -10. ,069 1.00 34. 28 L c

ATOM 4498 CD2 LEU L 73 -1. 579 24. 660 -12. ,284 1.00 33. 30 L c

ATOM 4502 C LEU L 73 -2. 326 28. 842 -11. ,944 1.00 39. 78 L c

ATOM 4503 O LEU L 73 -1. 987 29. 145 -13. ,097 1.00 41.70 L 0

ATOM 4505 N THR L 74 -1. 674 29. 243 -10. ,847 1.00 37. 29 L N

ATOM 4506 CA THR L 74 -0. 479 30. 088 -10. ,873 1.00 35. 88 L c

ATOM 4508 CB THR L 74 -0. 736 31. 459 -10. ,233 1.00 33. 16 L c

ATOM 4510 OGl THR L 74 -1. 840 32. 098 -10. ,883 1.00 39. 65 L 0

ATOM 4512 CG2 THR L 74 0. 483 32. 369 -10. ,333 1.00 32. 43 L c

ATOM 4516 C THR L 74 0. 635 29. 372 -10. ,098 1.00 40. 00 L c

ATOM 4517 O THR L 74 0. 434 28. 928 -8. 965 1.00 37. 04 L 0

ATOM 4519 N ILE L 75 1. 793 29. 235 -10. ,735 1.00 38. 81 L N

ATOM 4520 CA ILE L 75 3. 028 28. 872 -10. ,052 1.00 38. 64 L c

ATOM 4522 CB ILE L 75 3. 870 27. 853 -10. ,844 1.00 34. 90 L c

ATOM 4524 CGI ILE L 75 2. 967 26. 783 -11. ,474 1.00 36. 31 L c

ATOM 4527 CDl ILE L 75 3. 685 25. 831 -12. 415 1.00 35. 56 L c

ATOM 4531 CG2 ILE L 75 4. 913 27. 264 -9. 937 1.00 30. 85 L c

ATOM 4535 C ILE L 75 3. 827 30. 160 -9. ,913 1.00 40. 29 L c

ATOM 4536 O ILE L 75 4. 343 30. 684 -10. ,905 1.00 40. 29 L 0

ATOM 4538 N SER L 76 3. 967 30. 653 -8. ,684 1.00 43. 72 L N

ATOM 4539 CA SER L 76 4. 460 32. 019 -8. ,467 1.00 45. 63 L c

ATOM 4541 CB SER L 76 4. 101 32. 517 -7. ,049 1.00 48. 92 L c

ATOM 4544 OG SER L 76 5. 094 32. 158 -6. 088 1.00 49. 89 L 0

ATOM 4546 C SER L 76 5. 966 32. 165 -8. ,719 1.00 48. 57 L c

ATOM 4547 O SER L 76 6. 448 33. 267 -9. ,064 1.00 53. 90 L 0

ATOM 4549 N SER L 77 6. 710 31. 079 -8. ,517 1.00 45. 29 L N

ATOM 4550 CA SER L 77 8. 158 31. 103 -8. ,698 1.00 44. 60 L c

ATOM 4552 CB SER L 77 8. 863 31. 502 -7. ,387 1.00 48. 40 L c

ATOM 4555 OG SER L 77 10. 168 30. 952 -7. ,292 1.00 48. 72 L 0

ATOM 4557 C SER L 77 8. 623 29. 741 -9. ,200 1.00 43. 22 L c

ATOM 4558 O SER L 77 9. 030 28. 873 -8. ,423 1.00 45. 88 L 0

ATOM 4560 N LEU L 78 8. 573 29. 585 -10. ,522 1.00 36. 56 L N

ATOM 4561 CA LEU L 78 8. 832 28. 317 -11. ,180 1.00 37. 70 L c

ATOM 4563 CB LEU L 78 8. 750 28. 488 -12. ,704 1.00 36. 72 L c

ATOM 4566 CG LEU L 78 8. 802 27. 256 -13. ,620 1.00 38. ,10 L c

ATOM 4568 CDl LEU L 78 7. 586 26. 375 -13. ,395 1.00 32. ,47 L c

ATOM 4572 CD2 LEU L 78 8. 916 27. 662 -15. ,110 1.00 35. ,07 L c

ATOM 4576 C LEU L 78 10. 178 27. 725 -10. ,775 1.00 35. ,11 L c

ATOM 4577 O LEU L 78 11. 208 28. 386 -10. ,876 1.00 38. ,08 L 0

ATOM 4579 N GLN L 79 10. 155 26. 480 -10. ,315 1.00 37. 80 L N

ATOM 4580 CA GLN L 79 11. 369 25. 762 -9. ,922 1.00 39. 95 L c

ATOM 4582 CB GLN L 79 11. 242 25. 286 -8. ,471 1.00 41. 77 L c

ATOM 4585 CG GLN L 79 11. ,091 26. 410 -7. ,430 1.00 39. ,16 L c

ATOM 4588 CD GLN L 79 12. 279 27. 338 -7. ,381 1.00 43. ,01 L c

ATOM 4589 OEl GLN L 79 13. 423 26. 891 -7. ,245 1.00 45. ,36 L 0

ATOM 4590 NE2 GLN L 79 12. 022 28. 642 -7. ,471 1.00 40. ,10 L N

ATOM 4593 C GLN L 79 11. 619 24. 573 -10. ,879 1.00 38. ,08 L c

ATOM 4594 O GLN L 79 10. 693 24. 073 -11. ,507 1.00 38. ,53 L 0

ATOM 4596 N PRO L 80 12. 878 24. 128 -11. ,002 1.00 40. ,67 L N

ATOM 4597 CA PRO L 80 13. 200 23. 015 -11. ,895 1.00 41. ,65 L c

ATOM 4599 CB PRO L 80 14. ,635 22. 675 -11. ,500 1.00 43. .62 L c

ATOM 4602 CG PRO L 80 15. 206 23. 967 -11.082 1.00 42. ,88 L c

ATOM 4605 CD PRO L 80 14. 084 24. 657 -10. ,344 1.00 41. ,99 L c

ATOM 4608 C PRO L 80 12. 288 21. 790 -11. ,752 1.00 41.70 L c

ATOM 4609 0 PRO L 80 11. 867 21. 222 -12. ,764 1.00 40. ,54 L 0

ATOM 4610 N GLU L 81 11. 998 21. 393 -10. ,509 1.00 41. 26 L N

ATOM 4611 CA GLU L 81 11. 119 20. 253 -10. .212 1.00 41.41 L c human fD _Fab

ATOM 4613 CB GLU L 81 11. 128 19. 953 -8. 699 1.00 48. ,89 L C

ATOM 4616 CG GLU L 81 10. 628 21.086 -7. 793 1.00 54. ,78 L C

ATOM 4619 CD GLU L 81 11.752 21. 829 -7. 037 1.00 62. ,95 L C

ATOM 4620 OEl GLU L 81 12. 799 22. 229 -7. 656 1.00 58. 58 L 0

ATOM 4621 OE2 GLU L 81 11.562 22. 013 -5. 806 1.00 65. ,03 L 0

ATOM 4622 C GLU L 81 9. 661 20. 407 -10. 666 1.00 40. ,11 L C

ATOM 4623 O GLU L 81 8. 888 19. 463 -10. 590 1.00 39. ,53 L 0

ATOM 4625 N ASP L 82 9. 283 21. 601 -11. 112 1.00 40. ,76 L N

ATOM 4626 CA ASP L 82 7. 911 21. 864 -11.549 1.00 40. ,67 L C

ATOM 4628 CB ASP L 82 7. 527 23. 326 -11. 323 1.00 42. ,80 L c

ATOM 4631 CG ASP L 82 7. 663 23. 743 -9. 892 1.00 45. ,91 L c

ATOM 4632 ODl ASP L 82 7. 456 22. 877 -9. Oil 1.00 45. 26 L 0

ATOM 4633 OD2 ASP L 82 7. 994 24. 932 -9. 661 1.00 46. ,45 L 0

ATOM 4634 C ASP L 82 7. 657 21. 509 -13. 003 1.00 41. ,69 L c

ATOM 4635 O ASP L 82 6. 528 21. 673 -13. 487 1.00 44. ,51 L 0

ATOM 4637 N VAL L 83 8. 683 21. 027 -13. 696 1.00 39. ,15 L N

ATOM 4638 CA VAL L 83 8. 517 20. 602 -15. 069 1.00 38. ,47 L c

ATOM 4640 CB VAL L 83 9. 861 20. 325 -15. 756 1.00 40. ,10 L c

ATOM 4642 CGI VAL L 83 10. 533 19. 081 -15. 186 1.00 45. 50 L c

ATOM 4646 CG2 VAL L 83 9. 652 20. 160 -17. 247 1.00 45. 92 L c

ATOM 4650 C VAL L 83 7. 619 19. 366 -15. 063 1.00 41.48 L c

ATOM 4651 O VAL L 83 7. 950 18. 357 -14. 422 1.00 44. ,37 L 0

ATOM 4653 N ALA L 84 6. 495 19. 458 -15. 778 1.00 37. ,83 L N

ATOM 4654 CA ALA L 84 5. 433 18. 482 -15. 704 1.00 35. 03 L c

ATOM 4656 CB ALA L 84 4. 859 18. 442 -14. 302 1.00 36. ,88 L c

ATOM 4660 C ALA L 84 4. 367 18. 906 -16. 697 1.00 35. 87 L c

ATOM 4661 O ALA L 84 4. 506 19. 966 -17. 309 1.00 32. ,35 L 0

ATOM 4663 N THR L 85 3. 337 18. 066 -16. 893 1.00 34. 44 L N

ATOM 4664 CA THR L 85 2. 109 18. 504 -17. 563 1.00 33. 72 L c

ATOM 4666 CB THR L 85 1. 653 17. 519 -18. 643 1.00 33. 23 L c

ATOM 4668 OGl THR L 85 2. 672 17. 432 -19. 640 1.00 37. ,48 L 0

ATOM 4670 CG2 THR L 85 0. 356 17. 963 -19. 299 1.00 30. ,16 L c

ATOM 4674 C THR L 85 1. 043 18. 717 -16. 491 1.00 35. ,04 L c

ATOM 4675 O THR L 85 0. 930 17. 922 -15. 561 1.00 37. ,05 L 0

ATOM 4677 N TYR L 86 0. 300 19. 819 -16. 597 1.00 38. 23 L N

ATOM 4678 CA TYR L 86 -0. 727 20. 177 -15. 599 1.00 35. ,38 L c

ATOM 4680 CB TYR L 86 -0. 530 21. 593 -15. 059 1.00 38. ,47 L c

ATOM 4683 CG TYR L 86 0. 756 21. 715 -14. 279 1.00 37. ,97 L c

ATOM 4684 CDl TYR L 86 0. 804 21. 408 -12. 924 1.00 41. ,81 L c

ATOM 4686 CEl TYR L 86 1. 999 21. 467 -12. 211 1.00 40. ,89 L c

ATOM 4688 cz TYR L 86 3. 156 21. 843 -12. 861 1.00 41. ,50 L c

ATOM 4689 OH TYR L 86 4. 350 21. 913 -12. 170 1.00 41.05 L 0

ATOM 4691 CE2 TYR L 86 3. 125 22. 151 -14. 209 1.00 40. ,56 L c

ATOM 4693 CD2 TYR L 86 1. 932 22. 081 -14. 907 1.00 36. ,80 L c

ATOM 4695 C TYR L 86 -2. 083 20. 029 -16. 226 1.00 34. ,72 L c

ATOM 4696 O TYR L 86 -2. 260 20. ,374 -17. 397 1.00 31. .16 L 0

ATOM 4698 N TYR L 87 -3. 030 19. ,481 -15. ,447 1.00 34. ,27 L N

ATOM 4699 CA TYR L 87 -4. 417 19. 257 -15. 926 1.00 31. .60 L c

ATOM 4701 CB TYR L 87 -4. 725 17. 778 -16. 100 1.00 30. ,92 L c

ATOM 4704 CG TYR L 87 -3. 812 17. 022 -17. 029 1.00 28. .71 L c

ATOM 4705 CDl TYR L 87 -4. 127 16. 869 -18. 368 1.00 29. ,76 L c

ATOM 4707 CEl TYR L 87 -3. 272 16. 158 -19. 251 1.00 26. ,57 L c

ATOM 4709 CZ TYR L 87 -2. 123 15. 593 -18. 765 1.00 32. ,44 L c

ATOM 4710 OH TYR L 87 -1. 290 14. 889 -19. 613 1.00 33. ,66 L 0

ATOM 4712 CE2 TYR L 87 -1. 801 15. 711 -17. ,413 1.00 32. ,99 L c

ATOM 4714 CD2 TYR L 87 -2. 651 16. 426 -16. ,556 1.00 31.33 L c

ATOM 4716 C TYR L 87 -5. 413 19. ,803 -14. ,942 1.00 31. ,18 L c

ATOM 4717 0 TYR L 87 -5. 332 19. 490 -13. 756 1.00 34. ,73 L 0

ATOM 4719 N CYS L 88 -6. 361 20. 605 -15. 415 1.00 30. .90 L N

ATOM 4720 CA CYS L 88 -7. 481 20. 999 -14. 575 1.00 30. ,40 L c

ATOM 4722 CB CYS L 88 -8. 037 22. 325 -15. 019 1.00 34. ,53 L c

ATOM 4725 SG CYS L 88 -8. 905 22. 290 -16. 549 1.00 47. ,15 L s

ATOM 4727 C CYS L 88 -8. 561 19. ,913 -14. 635 1.00 32. .80 L c

ATOM 4728 0 CYS L 88 -8. 626 19. ,090 -15. ,575 1.00 33. ,13 L 0

ATOM 4730 N LEU L 89 -9. 378 19. ,863 -13. 607 1.00 33. .56 L N

ATOM 4731 CA LEU L 89 -10. 494 18. ,897 -13. ,566 1.00 33. .45 L c

ATOM 4733 CB LEU L 89 -10. 093 17. ,574 -12. ,903 1.00 28. .53 L c

ATOM 4736 CG LEU L 89 -11. 251 16. 607 -12. 619 1.00 33. ,45 L c human fD_Fab

ATOM 4738 CDl LEU L 89 -11. 409 15. ,553 -13. 683 1.00 24. 26 L C

ATOM 4742 CD2 LEU L 89 -11. 075 15. ,981 -11. 276 1.00 32. 30 L C

ATOM 4746 C LEU L 89 -11. 685 19. ,555 -12. 830 1.00 33. 18 L c

ATOM 4747 O LEU L 89 -11. 576 20. ,043 -11. 679 1.00 29. 89 L 0

ATOM 4749 N GLN L 90 -12. ,796 19. ,566 -13. 544 1.00 31. 68 L N

ATOM 4750 CA GLN L 90 -14. 050 20. ,094 -13. ,095 1.00 37. 35 L c

ATOM 4752 CB GLN L 90 -14. ,819 20. ,490 -14. 378 1.00 38. 34 L c

ATOM 4755 CG GLN L 90 -16. 291 20. ,631 -14. 278 1.00 44. 48 L c

ATOM 4758 CD GLN L 90 -17. 082 19. ,329 -14. 290 1.00 40. 86 L c

ATOM 4759 OEl GLN L 90 -16. 749 18. ,380 -14. 976 1.00 35. 40 L 0

ATOM 4760 NE2 GLN L 90 -18. 174 19. ,322 -13. 550 1.00 39. 92 L N

ATOM 4763 C GLN L 90 -14. 746 18. ,958 -12. 323 1.00 39. 41 L c

ATOM 4764 O GLN L 90 -14. ,840 17. ,833 -12. 833 1.00 33. 79 L 0

ATOM 4766 N SER L 91 -15. ,213 19. .246 -11. ,104 1.00 41. 54 L N

ATOM 4767 CA SER L 91 -15. 961 18. ,261 -10. 287 1.00 39. 18 L C

ATOM 4769 CB SER L 91 -15. 063 17. ,690 -9. ,189 1.00 41. 54 L C

ATOM 4772 OG SER L 91 -14. 822 18. ,637 -8. 152 1.00 45. 72 L 0

ATOM 4774 C SER L 91 -17. 276 18. ,859 -9. 683 1.00 39. 48 L C

ATOM 4775 O SER L 91 -17. 603 18. ,631 -8. 516 1.00 40. 49 L 0

ATOM 4777 N ASP L 92 -17. 997 19. ,613 -10. 510 1.00 33. 27 L N

ATOM 4778 CA ASP L 92 -19. 335 20. 111 -10. 236 1.00 36. 99 L c

ATOM 4780 CB ASP L 92 -19. ,759 21. ,013 -11. 423 1.00 39. 33 L c

ATOM 4783 CG ASP L 92 -21. 199 21. ,544 -11. 323 1.00 39. 69 L c

ATOM 4784 ODl ASP L 92 -21. 405 22. ,576 -10. 635 1.00 46. 81 L 0

ATOM 4785 OD2 ASP L 92 -22. 114 20. ,961 -11. 969 1.00 37. 09 L 0

ATOM 4786 C ASP L 92 -20. 355 18. ,980 -10. 099 1.00 36. 16 L c

ATOM 4787 O ASP L 92 -21. 296 19. ,054 -9. 319 1.00 37. 40 L 0

ATOM 4789 N SER L 93 -20. 179 17. ,943 -10. 902 1.00 41. 72 L N

ATOM 4790 CA SER L 93 -21. 124 16. ,839 -10. 965 1.00 37. 27 L c

ATOM 4792 CB SER L 93 -22. ,427 17. ,295 -11. 638 1.00 40. 52 L c

ATOM 4795 OG SER L 93 -22. 181 18. ,081 -12. 823 1.00 43. 05 L 0

ATOM 4797 C SER L 93 -20. 472 15. ,738 -11. 794 1.00 36. 85 L c

ATOM 4798 O SER L 93 -19. 450 15. ,961 -12. 447 1.00 35. 22 L 0

ATOM 4800 N LEU L 94 -21. 080 14. ,556 -11. 753 1.00 37. 02 L N

ATOM 4801 CA LEU L 94 -20. 637 13. 426 -12. 517 1.00 35. 53 L c

ATOM 4803 CB LEU L 94 -21. 141 12. ,119 -11. 890 1.00 36. 28 L c

ATOM 4806 CG LEU L 94 -20. 771 11. ,877 -10. 423 1.00 35. 07 L c

ATOM 4808 CDl LEU L 94 -21. 484 10. ,638 -9. ,882 1.00 31. 99 L c

ATOM 4812 CD2 LEU L 94 -19. 280 11. ,770 -10. ,314 1.00 30. 89 L c

ATOM 4816 C LEU L 94 -21.208 13. ,555 -13. 908 1.00 36. 82 L c

ATOM 4817 O LEU L 94 -22. 351 13. ,970 -14. 053 1.00 43. 10 L 0

ATOM 4819 N PRO L 95 -20. 433 13. ,182 -14. 942 1.00 34. 77 L N

ATOM 4820 CA PRO L 95 -19. 023 12. ,812 -14. 886 1.00 33. 72 L c

ATOM 4822 CB PRO L 95 -18. 768 12. ,176 -16. 259 1.00 37. 12 L c

ATOM 4825 CG PRO L 95 -19. 732 12. ,824 -17. 162 1.00 36. 72 L c

ATOM 4828 CD PRO L 95 -20. 978 13. ,052 -16. 307 1.00 35. ,45 L c

ATOM 4831 C PRO L 95 -18. 105 14. ,020 -14. ,728 1.00 34. ,75 L c

ATOM 4832 O PRO L 95 -18. 364 15. ,089 -15. ,291 1.00 33. ,75 L 0

ATOM 4833 N TYR L 96 -17. 017 13. ,840 -13. ,990 1.00 32. 98 L N

ATOM 4834 CA TYR L 96 -15. 963 14. ,859 -13. ,941 1.00 32. ,41 L c

ATOM 4836 CB TYR L 96 -14. 947 14. ,512 -12. 873 1.00 31. ,79 L c

ATOM 4839 CG TYR L 96 -15. 467 14. ,340 -11. ,459 1.00 33. 90 L c

ATOM 4840 CDl TYR L 96 -16. 680 14. ,889 -11. 036 1.00 36. 68 L c

ATOM 4842 CEl TYR L 96 -17. 128 14. ,729 -9. 686 1.00 29. ,86 L c

ATOM 4844 CZ TYR L 96 -16. ,326 14. ,053 -8. ,785 1.00 32. ,83 L c

ATOM 4845 OH TYR L 96 -16. 690 13. ,890 -7. ,475 1.00 35. ,29 L 0

ATOM 4847 CE2 TYR L 96 -15. 105 13. ,530 -9. ,188 1.00 32. 32 L c

ATOM 4849 CD2 TYR L 96 -14. 686 13. ,674 -10. ,510 1.00 32. ,70 L c

ATOM 4851 C TYR L 96 -15. 250 14, ,964 -15. ,300 1.00 32. ,02 L c

ATOM 4852 O TYR L 96 -15. 311 14. ,036 -16. 092 1.00 33. ,57 L 0

ATOM 4854 N THR L 97 -14. 562 16. ,078 -15. ,554 1.00 31. ,32 L N

ATOM 4855 CA THR L 97 -13. 903 16. ,314 -16. ,846 1.00 32. ,79 L c

ATOM 4857 CB THR L 97 -14. ,717 17, .246 -17. ,786 1.00 37. ,55 L c

ATOM 4859 OG1 THR L 97 -16. 119 16. ,912 -17. ,744 1.00 39. ,69 L 0

ATOM 4861 CG2 THR L 97 -14. 185 17. ,116 -19. ,218 1.00 33. ,61 L c

ATOM 4865 C THR L 97 -12. 559 16. ,990 -16. ,694 1.00 34. ,26 L c

ATOM 4866 O THR L 97 -12. 481 18. ,059 -16. ,084 1.00 34. ,49 L 0

ATOM 4868 N PHE L 98 -11. 536 16. ,391 -17. ,309 1.00 34. ,71 L N human fD_Fab

ATOM 4869 CA PHE L 98 -10. .209 16. ,987 -17. 396 1.00 34. ,97 L C

ATOM 4871 CB PHE L 98 -9. ,130 15. 898 -17. 680 1.00 36. ,14 L C

ATOM 4874 CG PHE L 98 -8. ,778 15. ,047 -16. 488 1.00 35. ,05 L c

ATOM 4875 CDl PHE L 98 -7. ,907 15. ,513 -15. 526 1.00 32. ,71 L c

ATOM 4877 CEl PHE L 98 -7. ,567 14. ,736 -14. 448 1.00 34. ,49 L c

ATOM 4879 CZ PHE L 98 -8. ,100 13. 466 -14. 326 1.00 34. ,37 L c

ATOM 4881 CE2 PHE L 98 -8. ,944 12. ,986 -15. 284 1.00 33. ,05 L c

ATOM 4883 CD2 PHE L 98 -9. ,295 13. ,772 -16. 351 1.00 37. ,16 L c

ATOM 4885 C PHE L 98 -10. ,091 18. ,027 -18. 505 1.00 35. 18 L c

ATOM 4886 O PHE L 98 -10. ,690 17. ,882 -19. 568 1.00 33. 83 L 0

ATOM 4888 N GLY L 99 -9. ,248 19. 033 -18. 268 1.00 35. ,72 L N

ATOM 4889 CA GLY L 99 -8. ,741 19. 905 -19. 341 1.00 33. 95 L c

ATOM 4892 C GLY L 99 -7. ,762 19. 141 -20. 225 1.00 37. 37 L c

ATOM 4893 O GLY L 99 -7. ,325 18. ,043 -19. 886 1.00 36. 13 L 0

ATOM 4895 N GLN L 100 -7. ,398 19. 727 -21. 365 1.00 37. 30 L N

ATOM 4896 CA GLN L 100 -6. ,548 19. ,038 -22. 336 1.00 32. 80 L c

ATOM 4898 CB GLN L 100 -6. ,587 19. ,748 -23. 664 1.00 35. ,58 L C

ATOM 4901 CG GLN L 100 -7. ,951 19. 791 -24. 277 1.00 36. 50 L c

ATOM 4904 CD GLN L 100 -8. 712 21. 028 -23. 912 1.00 37. 51 L c

ATOM 4905 OEl GLN L 100 -8. ,510 21. 628 -22. 842 1.00 37. 83 L 0

ATOM 4906 NE2 GLN L 100 -9. ,580 21. ,444 -24. 812 1.00 39. ,58 L N

ATOM 4909 C GLN L 100 -5. ,094 18. 907 -21. 904 1.00 34. 99 L C

ATOM 4910 O GLN L 100 -4. ,342 18. ,144 -22. 502 1.00 38. 49 L 0

ATOM 4912 N GLY L 101 -4. ,704 19. 682 -20. 892 1.00 35. 27 L N

ATOM 4913 CA GLY L 101 -3. 352 19. 677 -20. 347 1.00 33. 36 L C

ATOM 4916 C GLY L 101 -2. 480 20. 812 -20. 860 1.00 32. 02 L C

ATOM 4917 O GLY L 101 -2. ,653 21. 301 -21. 990 1.00 32. ,46 L 0

ATOM 4919 N THR L 102 -1. ,534 21. 224 -20. 017 1.00 33. 10 L N

ATOM 4920 CA THR L 102 -0. ,523 22. 221 -20. 364 1.00 31. 76 L C

ATOM 4922 CB THR L 102 -0. ,774 23. 550 -19. 684 1.00 32. 01 L C

ATOM 4924 OG1 THR L 102 -2. ,075 24. 016 -20. 055 1.00 29. 74 L 0

ATOM 4926 CG2 THR L 102 0. ,283 24. 616 -20. 123 1.00 33. 61 L C

ATOM 4930 C THR L 102 0. ,856 21. 707 -19. 971 1.00 32. 55 L c

ATOM 4931 O THR L 102 1, ,148 21. ,511 -18. 772 1.00 25. ,95 L 0

ATOM 4933 N LYS L 103 1. ,703 21. 510 -20. 987 1.00 30. ,82 L N

ATOM 4934 CA LYS L 103 3. ,071 21. ,110 -20. 758 1.00 33. 32 L c

ATOM 4936 CB LYS L 103 3. ,622 20. 378 -21. 982 1.00 36. 36 L c

ATOM 4939 CG LYS L 103 4. ,859 19. 569 -21. 667 1.00 37. 25 L c

ATOM 4942 CD LYS L 103 5. ,485 18. 977 -22. 919 1.00 40. 83 L c

ATOM 4945 CE LYS L 103 6. ,790 18. 312 -22. 573 1.00 40. 62 L c

ATOM 4948 NZ LYS L 103 6. .886 17. ,001 -23. 221 1.00 51.38 L N

ATOM 4952 C LYS L 103 3. ,956 22. 328 -20. 415 1.00 34. ,87 L c

ATOM 4953 O LYS L 103 4. ,014 23. 279 -21. 176 1.00 36. 58 L 0

ATOM 4955 N VAL L 104 4. ,647 22. ,264 -19. 271 1.00 36. ,48 L N

ATOM 4956 CA VAL L 104 5. 451 23. 361 -18. 713 1.00 32. ,34 L c

ATOM 4958 CB VAL L 104 5. 065 23. 658 -17. 231 1.00 28. ,05 L c

ATOM 4960 CGI VAL L 104 6. ,053 24. 597 -16. 572 1.00 24. 79 L c

ATOM 4964 CG2 VAL L 104 3. ,662 24. ,249 -17. 126 1.00 20. ,70 L c

ATOM 4968 C VAL L 104 6. ,933 22. 993 -18. 750 1.00 39. ,89 L c

ATOM 4969 O VAL L 104 7. ,379 22. 084 -18. 038 1.00 37. ,02 L 0

ATOM 4971 N GLU L 105 7. ,698 23. 712 -19. 573 1.00 41. ,15 L N

ATOM 4972 CA GLU L 105 9. ,116 23. ,459 -19. 709 1.00 45. ,11 L c

ATOM 4974 CB GLU L 105 9. ,462 23. 286 -21. 183 1.00 49. ,93 L c

ATOM 4977 CG GLU L 105 8. ,630 22. 192 -21. 888 1.00 58. ,13 L c

ATOM 4980 CD GLU L 105 8. ,392 22. 487 -23. 372 1.00 61. ,44 L c

ATOM 4981 OEl GLU L 105 7. ,538 23. ,361 -23. 686 1.00 65. ,02 L 0

ATOM 4982 OE2 GLU L 105 9. ,059 21. ,839 -24. 213 1.00 64. ,55 L 0

ATOM 4983 C GLU L 105 9. ,916 24. ,598 -19. 068 1.00 43. ,16 L c

ATOM 4984 0 GLU L 105 9. ,396 25. ,707 -18. 896 1.00 37. ,56 L 0

ATOM 4986 N ILE L 106 11.165 24. ,313 -18. 688 1.00 45. ,85 L N

ATOM 4987 CA ILE L 106 12. ,065 25. ,340 -18. 150 1.00 48. ,75 L c

ATOM 4989 CB ILE L 106 12. ,860 24. ,870 -16. 901 1.00 51. ,14 L c

ATOM 4991 CGI ILE L 106 11. ,939 24. ,748 -15. ,696 1.00 55. ,39 L c

ATOM 4994 CDl ILE L 106 12. ,402 25. ,581 -14. 502 1.00 58. 23 L c

ATOM 4998 CG2 ILE L 106 13. ,998 25. ,874 -16. 558 1.00 48. ,65 L c

ATOM 5002 C ILE L 106 13. ,070 25. ,834 -19. 183 1.00 48. ,57 L c

ATOM 5003 0 ILE L 106 13. ,790 25. ,040 -19. 785 1.00 44. ,66 L 0

ATOM 5005 N LYS L 107 13, ,114 27. ,153 -19. 367 1.00 50. 80 L N human fD_Fab

ATOM 5006 CA LYS L 107 14. ,147 27. ,805 -20. 162 1.00 52. 40 L C

ATOM 5008 CB LYS L 107 13. ,652 29. ,136 -20. 752 1.00 54. 16 L C

ATOM 5011 CG LYS L 107 14. 173 29. 429 -22. 164 1.00 59. 91 L c

ATOM 5014 CD LYS L 107 14. 636 30. 877 -22. 393 1.00 62. 28 L c

ATOM 5017 CE LYS L 107 13. ,727 31.924 -21. 728 1.00 68. 64 L c

ATOM 5020 NZ LYS L 107 13. ,954 33. ,300 -22. 291 1.00 68. 03 L N

ATOM 5024 C LYS L 107 15. ,354 28. ,053 -19. 258 1.00 50. 89 L c

ATOM 5025 O LYS L 107 15. ,250 28. ,747 -18. 238 1.00 49. 97 L 0

ATOM 5027 N ARG L 108 16. ,495 27. ,483 -19. 637 1.00 49. 65 L N

ATOM 5028 CA ARG L 108 17. ,732 27. ,643 -18. 882 1.00 48. 16 L c

ATOM 5030 CB ARG L 108 18. 054 26. 367 -18. 097 1.00 41.15 L c

ATOM 5033 CG ARG L 108 18. 236 25. 150 -18. 960 1.00 43. 03 L c

ATOM 5036 CD ARG L 108 19. ,243 24. ,192 -18. 375 1.00 46. 09 L c

ATOM 5039 NE ARG L 108 20. ,598 24. ,731 -18. 431 1.00 46. ,72 L N

ATOM 5041 CZ ARG L 108 21. ,637 24. ,223 -17. 773 1.00 45. ,70 L c

ATOM 5042 NHl ARG L 108 21. 492 23. 165 -16. 995 1.00 44. 56 L N

ATOM 5045 NH2 ARG L 108 22. 824 24. 801 -17. 874 1.00 44. 13 L N

ATOM 5048 C ARG L 108 18. 879 28. 031 -19. 823 1.00 48. 29 L c

ATOM 5049 O ARG L 108 18. 696 28. ,125 -21. 039 1.00 47. 79 L 0

ATOM 5051 N THR L 109 20. 058 28. 265 -19. 263 1.00 48. 42 L N

ATOM 5052 CA THR L 109 21. 216 28. ,611 -20. 088 1.00 48. ,51 L c

ATOM 5054 CB THR L 109 22. ,426 29. 092 -19. 256 1.00 44. ,23 L c

ATOM 5056 OGl THR L 109 22. ,970 28. 001 -18. 508 1.00 45. ,71 L 0

ATOM 5058 CG2 THR L 109 22. 003 30. ,188 -18. 304 1.00 39. 23 L c

ATOM 5062 C THR L 109 21. ,581 27. ,419 -20. 970 1.00 48. ,83 L c

ATOM 5063 0 THR L 109 21. 272 26. ,280 -20. 648 1.00 51. 87 L 0

ATOM 5065 N VAL L 110 22. 210 27. ,707 -22. 101 1.00 49. 67 L N

ATOM 5066 CA VAL L 110 22. 637 26. 680 -23. 052 1.00 45. 76 L c

ATOM 5068 CB VAL L 110 23. 183 27. 311 -24. 344 1.00 44. 22 L c

ATOM 5070 CGl VAL L 110 22. ,069 28. ,066 -25. 052 1.00 43. ,40 L c

ATOM 5074 CG2 VAL L 110 23. ,794 26. ,260 -25. 251 1.00 44. ,62 L c

ATOM 5078 C VAL L 110 23. ,712 25. ,806 -22. 420 1.00 42. ,26 L c

ATOM 5079 0 VAL L 110 24. 674 26. ,313 -21. 873 1.00 40. ,90 L 0

ATOM 5081 N ALA L 111 23. 525 24. ,492 -22. 488 1.00 45. ,41 L N

ATOM 5082 CA ALA L 111 24. 533 23. ,513 -22. 029 1.00 44. ,60 L c

ATOM 5084 CB ALA L 111 24. 001 22. ,710 -20. 829 1.00 39. 41 L c

ATOM 5088 C ALA L 111 24. 926 22. ,577 -23. 179 1.00 43. 11 L c

ATOM 5089 0 ALA L 111 24. ,078 22. ,031 -23. 871 1.00 40. ,94 L 0

ATOM 5091 N ALA L 112 26. ,220 22. ,427 -23. 412 1.00 49. ,15 L N

ATOM 5092 CA ALA L 112 26. 699 21.573 -24. 496 1.00 50. 08 L c

ATOM 5094 CB ALA L 112 28. ,151 21. ,901 -24. 864 1.00 42. ,07 L c

ATOM 5098 C ALA L 112 26. 569 20. ,135 -24. 027 1.00 49. 38 L c

ATOM 5099 0 ALA L 112 26. 734 19. ,877 -22. 835 1.00 51. 49 L 0

ATOM 5101 N PRO L 113 26. 225 19. 210 -24. 942 1.00 48. 90 L N

ATOM 5102 CA PRO L 113 26. 176 17. ,794 -24. 583 1.00 48. ,42 L c

ATOM 5104 CB PRO L 113 25. 516 17. ,144 -25. 804 1.00 50. ,58 L c

ATOM 5107 CG PRO L 113 25. ,887 18. ,032 -26. 932 1.00 49. ,33 L c

ATOM 5110 CD PRO L 113 25. 848 19. ,421 -26. 348 1.00 47. ,65 L c

ATOM 5113 C PRO L 113 27. 565 17. ,194 -24. 383 1.00 47. ,12 L c

ATOM 5114 0 PRO L 113 28. ,517 17. ,573 -25. 065 1.00 45. ,30 L 0

ATOM 5115 N SER L 114 27. 664 16. ,266 -23. 448 1.00 46. ,42 L N

ATOM 5116 CA SER L 114 28. 854 15. ,456 -23. 285 1.00 45. ,98 L c

ATOM 5118 CB SER L 114 29. 108 15. ,207 -21. 792 1.00 47. ,17 L c

ATOM 5121 OG SER L 114 30. 341 14. ,564 -21. 535 1.00 50. ,15 L 0

ATOM 5123 C SER L 114 28. ,559 14. ,175 -24. 056 1.00 46. 68 L c

ATOM 5124 0 SER L 114 27. ,543 13. ,531 -23. 815 1.00 50. ,95 L 0

ATOM 5126 N VAL L 115 29. ,430 13. ,813 -24. 993 1.00 46. ,24 L N

ATOM 5127 CA VAL L 115 29. ,102 12. ,798 -25. 997 1.00 44. ,53 L c

ATOM 5129 CB VAL L 115 29. 272 13. ,341 -27. 448 1.00 40. ,93 L c

ATOM 5131 CGl VAL L 115 28. ,894 12. ,287 -28. 489 1.00 33. ,23 L c

ATOM 5135 CG2 VAL L 115 28. 409 14. ,569 -27. 634 1.00 39. ,80 L c

ATOM 5139 C VAL L 115 29. 917 11.527 -25. 796 1.00 43. ,05 L c

ATOM 5140 0 VAL L 115 31. ,118 11. ,588 -25. 573 1.00 42. ,76 L 0

ATOM 5142 N PHE L 116 29. ,225 10. ,381 -25. 841 1.00 44. ,42 L N

ATOM 5143 CA PHE L 116 29. ,825 9. ,061 -25. 619 1.00 44. ,79 L c

ATOM 5145 CB PHE L 116 29. ,431 8. ,467 -24. 274 1.00 41. ,39 L c

ATOM 5148 CG PHE L 116 29. ,624 9. ,381 -23. 111 1.00 42. ,46 L c

ATOM 5149 CDl PHE L 116 30. ,703 9. ,238 -22. 281 1.00 42. ,31 L c human fD_Fab

ATOM 5151 CEl PHE L 116 30 867 10 046 -21 185 1.00 44 16 L C

ATOM 5153 CZ PHE L 116 29 927 11 008 -20 901 1.00 45 07 L c

ATOM 5155 CE2 PHE L 116 28 830 11 162 -21 718 1.00 42 29 L c

ATOM 5157 CD2 PHE L 116 28 682 10 352 -22 809 1.00 45 73 L c

ATOM 5159 C PHE L 116 29 380 8 081 -26 713 1.00 44 65 L c

ATOM 5160 O PHE L 116 28. 295 8 205 -27 273 1.00 43 63 L 0

ATOM 5162 N ILE L 117 30. 231 7 101 -26 993 1.00 42 86 L N

ATOM 5163 CA ILE L 117 29 949 6 122 -28 022 1.00 43 67 L c

ATOM 5165 CB ILE L 117 30 688 6 415 -29 357 1.00 40 91 L c

ATOM 5167 CGl ILE L 117 30 113 5 526 -30 474 1.00 40 94 L c

ATOM 5170 CDl ILE L 117 30. 491 5 978 -31 891 1.00 39 69 L c

ATOM 5174 CG2 ILE L 117 32. 242 6 329 -29 196 1.00 27 30 L c

ATOM 5178 C ILE L 117 30. 266 4 757 -27 456 1.00 42 84 L c

ATOM 5179 O ILE L 117 31.229 4 598 -26 705 1.00 42 49 L 0

ATOM 5181 N PHE L 118 29. 375 3 805 -27 742 1.00 42 14 L N

ATOM 5182 CA PHE L 118 29. 466 2 457 -27 229 1.00 42 81 L c

ATOM 5184 CB PHE L 118 28. 313 2 164 -26 284 1.00 36 27 L c

ATOM 5187 CG PHE L 118 28. 302 3 019 -25 058 1.00 35 72 L c

ATOM 5188 CDl PHE L 118 29. 089 2 681 -23 953 1.00 33 49 L c

ATOM 5190 CEl PHE L 118 29. 075 3 445 -22 811 1.00 33 92 L c

ATOM 5192 CZ PHE L 118 28. 248 4 574 -22 754 1.00 34 24 L c

ATOM 5194 CE2 PHE L 118 27. 453 4 902 -23 832 1.00 32 94 L c

ATOM 5196 CD2 PHE L 118 27. 498 4 135 -24 994 1.00 27 53 L c

ATOM 5198 C PHE L 118 29. 397 1 505 -28 402 1.00 47 09 L c

ATOM 5199 O PHE L 118 28. 371 1 474 -29 115 1.00 43 53 L 0

ATOM 5201 N PRO L 119 30. 490 0 732 -28 614 1.00 48 49 L N

ATOM 5202 CA PRO L 119 30. 456 -0 325 -29 619 1.00 47 48 L c

ATOM 5204 CB PRO L 119 31. 925 -0 790 -29 700 1.00 46 56 L c

ATOM 5207 CG PRO L 119 32. 728 0 300 -29 006 1.00 43 77 L c

ATOM 5210 CD PRO L 119 31.804 0 816 -27 952 1.00 41 04 L c

ATOM 5213 C PRO L 119 29. 523 -1 459 -29 191 1.00 47 07 L c

ATOM 5214 O PRO L 119 29. 155 -1 540 -28 006 1.00 49 41 L 0

ATOM 5215 N PRO L 120 29. 145 -2 327 -30 146 1.00 47 38 L N

ATOM 5216 CA PRO L 120 28. 343 -3 497 -29 835 1.00 48 65 L c

ATOM 5218 CB PRO L 120 28. 209 -4 208 -31 179 1.00 48 59 L c

ATOM 5221 CG PRO L 120 28. 614 -3 250 -32 196 1.00 47 84 L c

ATOM 5224 CD PRO L 120 29. 516 -2 267 -31 566 1.00 47 24 L c

ATOM 5227 C PRO L 120 29. 111 -4 390 -28 875 1.00 52 75 L c

ATOM 5228 O PRO L 120 30. 349 -4 490 -28 966 1.00 54 01 L 0

ATOM 5229 N SER L 121 28. 381 -5 028 -27 969 1.00 54 84 L N

ATOM 5230 CA SER L 121 28. 946 -5 994 -27 052 1.00 51 57 L c

ATOM 5232 CB SER L 121 27. 917 -6 338 -25 989 1.00 45 76 L c

ATOM 5235 OG SER L 121 26. 928 -7 169 -26 567 1.00 43 98 L 0

ATOM 5237 C SER L 121 29. 294 -7 268 -27 823 1.00 54 60 L c

ATOM 5238 O SER L 121 28. 665 -7 592 -28 839 1.00 55 02 L 0

ATOM 5240 N ASP L 122 30. 269 -8 013 -27 313 1.00 55 44 L N

ATOM 5241 CA ASP L 122 30. 597 -9 311 -27 885 1.00 57 29 L c

ATOM 5243 CB ASP L 122 31. 803 -9 924 -27 178 1.00 62 63 L c

ATOM 5246 CG ASP L 122 33. 126 -9 323 -27 645 1.00 66 05 L c

ATOM 5247 ODl ASP L 122 33. 209 -8 835 -28 812 1.00 56 75 L 0

ATOM 5248 OD2 ASP L 122 34. 080 -9 360 -26 825 1.00 69 49 L 0

ATOM 5249 C ASP L 122 29. 406 -10 267 -27 839 1.00 55 89 L c

ATOM 5250 O ASP L 122 29. 158 -10 996 -28 811 1.00 56 55 L 0

ATOM 5252 N GLU L 123 28. 652 -10 241 -26 740 1.00 55 51 L N

ATOM 5253 CA GLU L 123 27. 454 -11 080 -26 620 1.00 58 05 L c

ATOM 5255 CB GLU L 123 26. 807 -10 913 -25 238 1.00 57 58 L c

ATOM 5258 CG GLU L 123 25. 599 -11 821 -25 002 1.00 62 56 L c

ATOM 5261 CD GLU L 123 24. 826 -11 491 -23 725 1.00 65 05 L c

ATOM 5262 OEl GLU L 123 25. 403 -10 852 -22 814 1.00 68 23 L 0

ATOM 5263 OE2 GLU L 123 23. 638 -11 878 -23 646 1.00 63 42 L 0

ATOM 5264 C GLU L 123 26. 411 -10 796 -27 692 1.00 55 53 L c

ATOM 5265 O GLU L 123 25. 734 -11 703 -28 147 1.00 57 43 L 0

ATOM 5267 N GLN L 124 26. 266 -9 540 -28 095 1.00 53 06 L N

ATOM 5268 CA GLN L 124 25. 225 -9 207 -29 056 1.00 53 49 L c

ATOM 5270 CB GLN L 124 24. 923 -7 707 -29 054 1.00 46 17 L c

ATOM 5273 CG GLN L 124 23. 737 -7 345 -29 902 1.00 40 01 L c

ATOM 5276 CD GLN L 124 23. 614 -5 867 -30 189 1.00 43 65 L c

ATOM 5277 OEl GLN L 124 24. 439 -5 037 -29 749 1.00 43 56 L 0 human fD_Fab

ATOM 5278 NE2 GLN L 124 22. 577 -5. 520 -30. 946 1. 00 36. ,12 L N

ATOM 5281 C GLN L 124 25. 616 -9. 664 -30. 450 1. 00 54. ,05 L C

ATOM 5282 O GLN L 124 24. 775 -10. 160 -31. 200 1. 00 54. 97 L 0

ATOM 5284 N LEU L 125 26. 885 -9. 473 -30. 799 1.00 59. 71 L N

ATOM 5285 CA LEU L 125 27. 423 -9. 975 -32. 071 1. 00 61. 94 L C

ATOM 5287 CB LEU L 125 28. 944 -9. 758 -32. 168 1.00 61. ,02 L C

ATOM 5290 CG LEU L 125 29. 597 -8. 411 -32. 536 1. 00 58. 93 L c

ATOM 5292 CDl LEU L 125 28. 893 -7. 659 -33 . 665 1.00 56. 16 L c

ATOM 5296 CD2 LEU L 125 29. 707 -7. 560 -31. 324 1. 00 59. 33 L c

ATOM 5300 C LEU L 125 27. 093 -11.468 -32. 262 1.00 62. 78 L c

ATOM 5301 O LEU L 125 26. 715 -11. 883 - 33 . 362 1. 00 61. 32 L 0

ATOM 5303 N LYS L 126 27. 229 -12. 245 -31. 183 1.00 67. 75 L N

ATOM 5304 CA LYS L 126 26. 823 -13. 663 -31. 145 1. 00 72. 81 L c

ATOM 5306 CB LYS L 126 26. 790 -14. 142 -29. 686 1. 00 77. 09 L c

ATOM 5309 CG LYS L 126 27. 284 -15. 559 -29. 465 1.00 81. 38 L c

ATOM 5312 CD LYS L 126 27. 600 -15. 802 -27. 992 1. 00 81. ,19 L c

ATOM 5315 CE LYS L 126 28. 899 -15. 113 -27. 556 1.00 84. ,36 L c

ATOM 5318 NZ LYS L 126 28. 812 -14. 602 -26. 144 1. 00 84. 63 L N

ATOM 5322 C LYS L 126 25. 450 -13. 900 -31. 790 1.00 74. 90 L c

ATOM 5323 0 LYS L 126 25. 304 -14. 750 -32. 670 1. 00 75. 61 L 0

ATOM 5325 N SER L 127 24. 457 -13. 121 -31.358 1.00 75. 07 L N

ATOM 5326 CA SER L 127 23. 070 -13. 268 -31. 814 1. 00 70. ,26 L C

ATOM 5328 CB SER L 127 22. 109 -12. 501 -30. 881 1.00 72. ,18 L C

ATOM 5331 OG SER L 127 22. 146 - 11.098 -31. 089 1. 00 71. ,13 L 0

ATOM 5333 C SER L 127 22. 838 -12. 862 -33. 281 1.00 69. ,16 L C

ATOM 5334 0 SER L 127 21. 757 -13. 114 - 33 . 821 1. 00 68. 65 L 0

ATOM 5336 N GLY L 128 23. 831 -12. 237 -33. 918 1.00 67. 14 L N

ATOM 5337 CA GLY L 128 23. 752 -11. 907 -35. 346 1.00 65. 59 L C

ATOM 5340 C GLY L 128 23. 413 -10. 463 -35. 679 1. 00 66. 30 L C

ATOM 5341 0 GLY L 128 23. 073 -10. 140 -36. 828 1.00 63. ,42 L 0

ATOM 5343 N THR L 129 23. 524 -9. 583 -34. 684 1. 00 66. ,28 L N

ATOM 5344 CA THR L 129 23. 211 -8. 161 -34. 868 1.00 62. ,18 L c

ATOM 5346 CB THR L 129 21. 729 -7. 884 -34. 465 1. 00 66. 25 L c

ATOM 5348 OGl THR L 129 21.354 -6. 550 -34. 856 1.00 64. ,76 L 0

ATOM 5350 CG2 THR L 129 21. 512 -8. 099 -32. 957 1. 00 69. ,40 L c

ATOM 5354 C THR L 129 24. 184 -7. 253 -34. 094 1.00 56. 00 L c

ATOM 5355 0 THR L 129 24. 731 -7. 650 - 33 . 064 1. 00 55. ,01 L 0

ATOM 5357 N ALA L 130 24. 415 -6. 048 -34. 612 1.00 52. ,96 L N

ATOM 5358 CA ALA L 130 25. 257 -5. 053 - 33 . 939 1. 00 49. ,66 L C

ATOM 5360 CB ALA L 130 26. 514 -4. 827 -34. 716 1.00 38. ,29 L C

ATOM 5364 C ALA L 130 24. 519 -3. 726 -33 . 742 1. 00 48. 82 L c

ATOM 5365 0 ALA L 130 24. 135 -3. 069 -34. 713 1.00 50. 68 L 0

ATOM 5367 N SER L 131 24. 324 -3. 342 -32. 480 1. 00 47. 22 L N

ATOM 5368 CA SER L 131 23. 850 -2. 003 -32. 121 1.00 44. ,47 L C

ATOM 5370 CB SER L 131 22. 782 -2. 119 -31. 036 1. 00 43. ,25 L c

ATOM 5373 OG SER L 131 21. 736 -2. 972 -31. 473 1.00 43. ,16 L 0

ATOM 5375 C SER L 131 25. 013 -1. 100 -31. ,639 1. 00 39. ,04 L c

ATOM 5376 0 SER L 131 25. 675 -1. 404 -30. ,652 1.00 39. ,98 L 0

ATOM 5378 N VAL L 132 25. 231 0. 017 -32. 327 1. 00 39. ,66 L N

ATOM 5379 CA VAL L 132 26. 186 1. 051 -31. 892 1.00 41.48 L c

ATOM 5381 CB VAL L 132 27. 033 1. 548 -33. 098 1.00 37. ,21 L c

ATOM 5383 CGI VAL L 132 28. 282 2. 316 -32. 640 1. 00 31. ,30 L c

ATOM 5387 CG2 VAL L 132 27. 411 0. 363 - 33 . 991 1.00 36. ,43 L c

ATOM 5391 C VAL L 132 25. 398 2. 223 -31. 259 1.00 43. ,23 L c

ATOM 5392 0 VAL L 132 24. 507 2. 803 -31. ,900 1.00 38. ,42 L 0

ATOM 5394 N VAL L 133 25. 715 2. ,552 -30. ,004 1. 00 43. .19 L N

ATOM 5395 CA VAL L 133 24. 970 3. 572 -29. ,255 1. 00 40. ,97 L C

ATOM 5397 CB VAL L 133 24. 552 3. 054 -27. 866 1.00 34. ,05 L C

ATOM 5399 CGI VAL L 133 23. 810 4. 145 -27. 078 1. 00 29. ,07 L C

ATOM 5403 CG2 VAL L 133 23. 711 1. 741 -27. 996 1. 00 31. ,84 L c

ATOM 5407 C VAL L 133 25. 760 4. 890 -29. 075 1.00 43. , 99 L c

ATOM 5408 0 VAL L 133 26. 914 4. 905 -28. ,641 1.00 40. .46 L 0

ATOM 5410 N CYS L 134 25. 109 5. 997 -29. ,413 1. 00 46. ,83 L N

ATOM 5411 CA CYS L 134 25. 649 7. 312 -29. ,147 1.00 43. ,96 L c

ATOM 5413 CB CYS L 134 25. 619 8. 173 -30. ,407 1. 00 46. ,90 L c

ATOM 5416 SG CYS L 134 26. 836 9. 491 -30. ,377 1. 00 51. ,58 L S

ATOM 5418 C CYS L 134 24. 846 7. 999 -28. 053 1.00 42. ,57 L c

ATOM 5419 0 CYS L 134 23. 651 8. 191 -28. 187 1. 00 40. ,87 L 0 human fD_Fab

ATOM 5421 N LEU L 135 25.523 8. 387 -26. 981 1.00 40. 87 L N

ATOM 5422 CA LEU L 135 24.883 9. 086 -25. 877 1.00 41. 05 L C

ATOM 5424 CB LEU L 135 25.262 8. 422 -24. 536 1.00 41. 94 L C

ATOM 5427 CG LEU L 135 24.945 9. 147 -23. 222 1.00 37. 54 L C

ATOM 5429 CDl LEU L 135 23.430 9. 259 -23. 035 1.00 36. 05 L C

ATOM 5433 CD2 LEU L 135 25.633 8. 466 -22. 027 1.00 36. 10 L c

ATOM 5437 C LEU L 135 25.283 10. 560 -25. 881 1.00 43. 54 L c

ATOM 5438 O LEU L 135 26.452 10. 887 -25. 746 1.00 41. 08 L 0

ATOM 5440 N LEU L 136 24.290 11. 431 -26. 044 1.00 45. 15 L N

ATOM 5441 CA LEU L 136 24.424 12. 867 -25. 799 1.00 40. 22 L c

ATOM 5443 CB LEU L 136 23.646 13. 667 -26. 834 1.00 40. 10 L c

ATOM 5446 CG LEU L 136 24.119 13. 798 -28. 277 1.00 35. 38 L c

ATOM 5448 CDl LEU L 136 24.446 12. 459 -28. 931 1.00 32. 90 L c

ATOM 5452 CD2 LEU L 136 23.008 14. 541 -29. 013 1.00 36. 16 L c

ATOM 5456 C LEU L 136 23.829 13. 178 -24. 429 1.00 42. 61 L c

ATOM 5457 O LEU L 136 22.621 13. 158 -24. 255 1.00 44. 03 L 0

ATOM 5459 N ASN L 137 24.686 13. 502 -23. 471 1.00 43. 60 L N

ATOM 5460 CA ASN L 137 24.285 13. 628 -22. 087 1.00 41.98 L c

ATOM 5462 CB ASN L 137 25.267 12. 855 -21. 188 1.00 41. 33 L c

ATOM 5465 CG ASN L 137 24.584 12. 241 -19. 997 1.00 37. 11 L c

ATOM 5466 ODl ASN L 137 23.409 11. 912 -20. 064 1.00 34. 55 L 0

ATOM 5467 ND2 ASN L 137 25.305 12. 097 -18. 899 1.00 39. 60 L N

ATOM 5470 C ASN L 137 24.189 15. 067 -21.590 1.00 43. 36 L c

ATOM 5471 O ASN L 137 25.118 15. 857 -21. 772 1.00 42. 54 L 0

ATOM 5473 N ASN L 138 23.065 15. 368 -20. 929 1.00 45. 15 L N

ATOM 5474 CA ASN L 138 22.876 16. 602 -20. 161 1.00 42. 87 L c

ATOM 5476 CB ASN L 138 23.761 16. 556 -18. 915 1.00 39. 48 L C

ATOM 5479 CG ASN L 138 23.332 15. 462 -17. 940 1.00 43. 15 L C

ATOM 5480 ODl ASN L 138 22.238 14. 888 -18. 049 1.00 45. 64 L 0

ATOM 5481 ND2 ASN L 138 24.192 15. 162 -16. 996 1.00 43. 41 L N

ATOM 5484 C ASN L 138 23.079 17. 900 -20. 949 1.00 42. 30 L C

ATOM 5485 O ASN L 138 23.943 18. 723 -20. 614 1.00 43. 40 L 0

ATOM 5487 N PHE L 139 22.268 18. 071 -21. 993 1.00 39. 73 L N

ATOM 5488 CA PHE L 139 22.313 19. 264 -22. 840 1.00 41. 08 L C

ATOM 5490 CB PHE L 139 22.617 18. 891 -24. 289 1.00 35. 82 L C

ATOM 5493 CG PHE L 139 21.582 18. 004 -24. 945 1.00 34. 55 L c

ATOM 5494 CDl PHE L 139 20.537 18. 550 -25. 657 1.00 38. 43 L c

ATOM 5496 CE1 PHE L 139 19.600 17. 743 -26. 314 1.00 36. 03 L c

ATOM 5498 cz PHE L 139 19.707 16. 385 -26. 246 1.00 37. 97 L c

ATOM 5500 CE2 PHE L 139 20.750 15. 817 -25. 541 1.00 36. 18 L c

ATOM 5502 CD2 PHE L 139 21.686 16. 631 -24. 899 1.00 36. 90 L c

ATOM 5504 C PHE L 139 21.031 20. 104 -22. 780 1.00 42. 49 L c

ATOM 5505 O PHE L 139 19.963 19. 629 -22. 373 1.00 42. 55 L 0

ATOM 5507 N TYR L 140 21.165 21. 364 -23. 165 1.00 43. 46 L N

ATOM 5508 CA TYR L 140 20.036 22. 258 -23. 318 1.00 41. 30 L c

ATOM 5510 CB TYR L 140 19.703 22. 958 -21. 985 1.00 42. 20 L c

ATOM 5513 CG TYR L 140 18.472 23. 803 -22. 147 1.00 43. 03 L c

ATOM 5514 CDl TYR L 140 17.226 23. 268 -21.914 1.00 40. 82 L c

ATOM 5516 CEl TYR L 140 16.093 24. ,004 -22. 106 1.00 43. 23 L c

ATOM 5518 CZ TYR L 140 16.183 25. 295 -22. 588 1.00 42. 52 L c

ATOM 5519 OH TYR L 140 15.028 26. 004 -22. 788 1.00 42. 38 L 0

ATOM 5521 CE2 TYR L 140 17.409 25. 854 -22. 869 1.00 44. 15 L c

ATOM 5523 CD2 TYR L 140 18.552 25. 101 -22. 665 1.00 44. 84 L c

ATOM 5525 C TYR L 140 20.393 23. 284 -24. 390 1.00 40. 33 L c

ATOM 5526 O TYR L 140 21.489 23. 826 -24. 355 1.00 42. 85 L 0

ATOM 5528 N PRO L 141 19.486 23. 575 -25. 340 1.00 44. 05 L N

ATOM 5529 CA PRO L 141 18.095 23. ,167 -25. ,539 1.00 47. 12 L c

ATOM 5531 CB PRO L 141 17.543 24. 275 -26. 431 1.00 44. 96 L c

ATOM 5534 CG PRO L 141 18.704 24. 689 -27. 258 1.00 46. 12 L c

ATOM 5537 CD PRO L 141 19.933 24. 497 -26. 401 1.00 45. 97 L c

ATOM 5540 C PRO L 141 17.905 21. 770 -26. 162 1.00 45. 02 L c

ATOM 5541 0 PRO L 141 18.867 21. 081 -26. 424 1.00 45. 97 L 0

ATOM 5542 N ARG L 142 16.656 21. 371 -26. 375 1.00 49. 41 L N

ATOM 5543 CA ARG L 142 16.302 19. 997 -26. 766 1.00 50. ,48 L c

ATOM 5545 CB ARG L 142 14.785 19. ,805 -26. ,661 1.00 54. ,32 L c

ATOM 5548 CG ARG L 142 14.323 18. ,368 -26. 772 1.00 55. 76 L c

ATOM 5551 CD ARG L 142 12.895 18. 211 -26. 300 1.00 61. 09 L c

ATOM 5554 NE ARG L 142 12.358 16. 886 -26. 600 1.00 64. 81 L N human fD_Fab

ATOM 5556 CZ ARG L 142 11. 940 16. 492 -27. ,807 1.00 72. ,10 L C

ATOM 5557 NHl ARG L 142 12. ,000 17. 320 -28. ,850 1.00 75. ,18 L N

ATOM 5560 NH2 ARG L 142 11. 457 15. 259 -27. ,981 1.00 69. ,36 L N

ATOM 5563 C ARG L 142 16. ,770 19. 607 -28. ,163 1.00 50. ,69 L C

ATOM 5564 O ARG L 142 17. ,037 18. 437 -28. ,430 1.00 50. ,59 L 0

ATOM 5566 N GLU L 143 16. ,867 20. 597 -29. ,045 1.00 52. ,13 L N

ATOM 5567 CA GLU L 143 17. ,190 20. 378 -30. ,442 1.00 50. ,78 L C

ATOM 5569 CB GLU L 143 16. ,875 21. 652 -31. ,240 1.00 54. ,86 L C

ATOM 5572 CG GLU L 143 15. 362 21. 973 -31. ,371 1.00 59. 99 L C

ATOM 5575 CD GLU L 143 14. ,653 22. 493 -30. ,079 1.00 61. 27 L c

ATOM 5576 OEl GLU L 143 15. 254 23. 218 -29. ,238 1.00 58. ,45 L 0

ATOM 5577 OE2 GLU L 143 13. 452 22. 181 -29. ,936 1.00 62. ,39 L 0

ATOM 5578 C GLU L 143 18. ,665 19. 969 -30. ,588 1.00 48. ,43 L c

ATOM 5579 O GLU L 143 19. ,557 20. 711 -30. ,196 1.00 47. 86 L 0

ATOM 5581 N ALA L 144 18. ,887 18. 771 -31. ,131 1.00 45. ,09 L N

ATOM 5582 CA ALA L 144 20. ,218 18. 218 -31. ,413 1.00 46. 23 L c

ATOM 5584 CB ALA L 144 20. ,705 17. 346 -30. 266 1.00 32. ,72 L c

ATOM 5588 C ALA L 144 20. 164 17. 402 -32. 704 1.00 44. ,67 L c

ATOM 5589 O ALA L 144 19. 132 16. 876 -33. 053 1.00 46. 24 L 0

ATOM 5591 N LYS L 145 21.273 17. 329 -33. ,425 1.00 49. ,37 L N

ATOM 5592 CA LYS L 145 21.340 16. 569 -34. ,672 1.00 50. ,82 L c

ATOM 5594 CB LYS L 145 21. 588 17. 513 -35. ,855 1.00 53. ,42 L c

ATOM 5597 CG LYS L 145 21. ,618 16. 867 -37. ,263 1.00 54. ,31 L c

ATOM 5600 CD LYS L 145 22. 239 17. 846 -38. ,281 1.00 56. ,75 L c

ATOM 5603 CE LYS L 145 21.594 17. 778 -39. ,672 1.00 58. 62 L c

ATOM 5606 NZ LYS L 145 21. 928 18. 988 -40. ,515 1.00 54. ,80 L N

ATOM 5610 C LYS L 145 22. 463 15. 550 -34. 509 1.00 47. ,66 L c

ATOM 5611 0 LYS L 145 23. 571 15. 903 -34. ,130 1.00 42. ,78 L 0

ATOM 5613 N VAL L 146 22. 154 14. 282 -34. ,755 1.00 50. ,97 L N

ATOM 5614 CA VAL L 146 23. ,152 13. 214 -34. ,701 1.00 52. ,66 L c

ATOM 5616 CB VAL L 146 22. 768 12. 083 -33. ,691 1.00 48. ,03 L c

ATOM 5618 CGI VAL L 146 23. 940 11. 123 -33. ,514 1.00 43. ,85 L c

ATOM 5622 CG2 VAL L 146 22. 356 12. 664 -32. ,358 1.00 44. ,75 L c

ATOM 5626 C VAL L 146 23. 299 12. 598 -36. ,087 1.00 52. 92 L c

ATOM 5627 0 VAL L 146 22. 308 12. 226 -36. ,694 1.00 55. ,42 L 0

ATOM 5629 N GLN L 147 24. 528 12. 491 -36. ,580 .1.00 55. ,00 L N

ATOM 5630 CA GLN L 147 24. 786 11. 920 -37. ,905 1.00 56. ,58 L c

ATOM 5632 CB GLN L 147 25. 313 12. 968 -38. ,909 1.00 58. ,16 L c

ATOM 5635 CG GLN L 147 24. ,273 14. 041 -39. ,282 1.00 61.93 L c

ATOM 5638 CD GLN L 147 24. 629 14. 858 -40. ,530 1.00 66. ,47 L c

ATOM 5639 OEl GLN L 147 25. 800 15. 133 -40. ,825 1.00 68, ,94 L 0

ATOM 5640 NE2 GLN L 147 23. 602 15. 255 -41. ,264 1.00 71. ,60 L N

ATOM 5643 C GLN L 147 25. 775 10. 787 -37. ,749 1.00 55. .22 L c

ATOM 5644 0 GLN L 147 26. 789 10. 919 -37. ,076 1.00 53. ,77 L 0

ATOM 5646 N TRP L 148 25. 464 9. 663 -38. ,368 1.00 53. 28 L N

ATOM 5647 CA TRP L 148 26. 304 8. 489 -38. ,273 1.00 52. ,81 L c

ATOM 5649 CB TRP L 148 25. ,424 7. 237 -38. ,072 1.00 45. .07 L c

ATOM 5652 CG TRP L 148 25. ,013 7. 039 -36. ,663 1.00 41.91 L c

ATOM 5653 CDl TRP L 148 23. 828 7. 399 -36. .088 1.00 42. .92 L c

ATOM 5655 NEl TRP L 148 23. 817 7. 029 -34. ,764 1.00 42. ,81 L N

ATOM 5657 CE2 TRP L 148 25. 013 6. 437 -34. ,460 1.00 40. ,65 L C

ATOM 5658 CD2 TRP L 148 25. 789 6. 425 -35. ,633 1.00 40. .26 L C

ATOM 5659 CE3 TRP L 148 27. 067 5. 854 -35. ,592 1.00 42. ,10 L c

ATOM 5661 CZ3 TRP L 148 27. 519 5. 333 -34. ,407 1.00 42. .91 L c

ATOM 5663 CH2 TRP L 148 26. ,713 5. 347 -33. .255 1.00 43, ,17 L c

ATOM 5665 CZ2 TRP L 148 25. 469 5. 908 -33. ,263 1.00 43. .30 L c

ATOM 5667 C TRP L 148 27. ,194 8. 339 -39. .509 1.00 50. .33 L c

ATOM 5668 0 TRP L 148 26. 775 8. 625 -40. ,619 1.00 47. ,50 L 0

ATOM 5670 N LYS L 149 28. 430 7. 901 -39. .285 1.00 54. ,01 L N

ATOM 5671 CA LYS L 149 29. 364 7. 592 -40. .355 1.00 56. ,31 L c

ATOM 5673 CB LYS L 149 30. 438 8. 674 -40. ,458 1.00 59. ,36 L c

ATOM 5676 CG LYS L 149 29. 940 9. 965 -41. .034 1.00 59. ,49 L c

ATOM 5679 CD LYS L 149 31. ,087 10. 842 -41. .465 1.00 62, ,05 L c

ATOM 5682 CE LYS L 149 30. ,583 12. 037 -42. .292 1.00 67. .96 L c

ATOM 5685 NZ LYS L 149 29. 612 12. 933 -41. .563 1.00 70. .23 L N

ATOM 5689 C LYS L 149 30. 042 6. 249 -40. ,115 1.00 54, .16 L c

ATOM 5690 0 LYS L 149 30. 626 6. 016 -39. ,057 1.00 51, ,78 L 0

ATOM 5692 N VAL L 150 29. 970 5. 384 -41.121 1.00 54. .55 L N human fD_Fab

ATOM 5693 CA VAL L 150 30.699 4 126 -41 129 1.00 55 08 L C

ATOM 5695 CB VAL L 150 29.760 2 925 -41 382 1.00 44 90 L c

ATOM 5697 CGI VAL L 150 30.548 1 622 -41 328 1.00 38 86 L c

ATOM 5701 CG2 VAL L 150 28.610 2 924 -40 368 1.00 34 81 L c

ATOM 5705 C VAL L 150 31.749 4 196 -42 233 1.00 55 45 L c

ATOM 5706 0 VAL L 150 31.408 4 388 -43 404 1.00 54 59 L 0

ATOM 5708 N ASP L 151 33.019 4 024 -41 861 1.00 57 42 L N

ATOM 5709 CA ASP L 151 34.149 4 285 -42 768 1.00 58 26 L c

ATOM 5711 CB ASP L 151 34.315 3 158 -43 803 1.00 55 75 L c

ATOM 5714 CG ASP L 151 34.854 1 869 -43 216 1.00 55 54 L c

ATOM 5715 ODl ASP L 151 35.658 1 892 -42 258 1.00 50 93 L 0

ATOM 5716 002 ASP L 151 34.485 0 810 -43 767 1.00 56 01 L 0

ATOM 5717 C ASP L 151 33.948 5 612 -43 518 1.00 57 64 L c

ATOM 5718 0 ASP L 151 34.154 5 690 -44 732 1.00 56 65 L 0

ATOM 5720 N ASN L 152 33.514 6 634 -42 788 1.00 58 24 L N

ATOM 5721 CA ASN L 152 33.278 7 971 -43 338 1.00 59 46 L c

ATOM 5723 CB ASN L 152 34.596 8 565 -43 856 1.00 63 45 L c

ATOM 5726 CG ASN L 152 34.514 10 059 -44 080 1.00 65 32 L c

ATOM 5727 ODl ASN L 152 34.105 10 822 -43 189 1.00 67 65 L 0

ATOM 5728 ND2 ASN L 152 34.897 10 490 -45 277 1.00 67 08 L N

ATOM 5731 C ASN L 152 32.195 8 067 -44 418 1.00 58 97 L c

ATOM 5732 0 ASN L 152 32.124 9 069 -45 128 1.00 60 52 L 0

ATOM 5734 N ALA L 153 31.360 7 036 -44 533 1.00 58 63 L N

ATOM 5735 CA ALA L 153 30.174 7 063 -45 391 1.00 59 33 L c

ATOM 5737 CB ALA L 153 29.989 5 720 -46 095 1.00 55. 97 L c

ATOM 5741 C ALA L 153 28.937 7 381 -44 549 1.00 60 75 L c

ATOM 5742 0 ALA L 153 28.531 6 572 -43 688 1.00 60 95 L 0

ATOM 5744 N LEU L 154 28.324 8 536 -44 817 1.00 57 65 L N

ATOM 5745 CA LEU L 154 27.164 8 993 -44 043 1.00 57 10 L c

ATOM 5747 CB LEU L 154 26.734 10 425 -44 414 1.00 60 28 L c

ATOM 5750 CG LEU L 154 25.406 10 992 -43 836 1.00 64 48 L c

ATOM 5752 CDl LEU L 154 25.195 10 804 -42 287 1.00 64 36 L c

ATOM 5756 CD2 LEU L 154 25.248 12 487 -44 204 1.00 60 40 L c

ATOM 5760 C LEU L 154 25.989 8 018 -44 166 1.00 58 12 L c

ATOM 5761 0 LEU L 154 25.651 7 522 -45 253 1.00 55 93 L 0

ATOM 5763 N GLN L 155 25.381 7 731 -43 022 1.00 54 77 L N

ATOM 5764 CA GLN L 155 24.334 6 741 -42 926 1.00 49 90 L c

ATOM 5766 CB GLN L 155 24.475 5 979 -41 608 1.00 46 93 L c

ATOM 5769 CG GLN L 155 25.736 5 204 -41 472 1.00 44 15 L c

ATOM 5772 CD GLN L 155 25.902 4 192 -42 592 1.00 49 82 L c

ATOM 5773 OEl GLN L 155 25.122 3 232 -42 710 1.00 47 02 L 0

ATOM 5774 NE2 GLN L 155 26.911 4 413 -43 437 1.00 49 06 L N

ATOM 5777 C GLN L 155 22.973 7 402 -42 972 1.00 48 25 L c

ATOM 5778 0 GLN L 155 22.804 8 514 -42 503 1.00 53 59 L 0

ATOM 5780 N SER L 156 21.997 6 717 -43 543 1.00 48 22 L N

ATOM 5781 CA SER L 156 20.610 7 109 -43 350 1.00 51 35 L c

ATOM 5783 CB SER L 156 20.107 8 107 -44 408 1.00 56 43 L c

ATOM 5786 OG SER L 156 19.754 7 479 -45 629 1.00 60 18 L 0

ATOM 5788 C SER L 156 19.758 5 859 -43 306 1.00 48 34 L c

ATOM 5789 0 SER L 156 20.108 4 840 -43 900 1.00 48 12 L 0

ATOM 5791 N GLY L 157 18.677 5 935 -42 538 1.00 47 48 L N

ATOM 5792 CA GLY L 157 17.661 4 880 -42 488 1.00 47 13 L c

ATOM 5795 C GLY L 157 17.868 3 806 -41 445 1.00 46 38 L c

ATOM 5796 0 GLY L 157 16.932 3 082 -41 120 1.00 48 95 L 0

ATOM 5798 N ASN L 158 19.078 3 706 -40 904 1.00 45 80 L N

ATOM 5799 CA ASN L 158 19.457 2 604 -40 010 1.00 46 35 L C

ATOM 5801 CB ASN L 158 20.656 1 843 -40 600 1.00 46 18 L C

ATOM 5804 CG ASN L 158 21.856 2 741 -40 868 1.00 47 83 L c

ATOM 5805 ODl ASN L 158 21.825 3 941 -40 587 1.00 44 96 L 0

ATOM 5806 ND2 ASN L 158 22.931 2 152 -41 406 1.00 48 89 L N

ATOM 5809 C ASN L 158 19.767 3 049 -38 577 1.00 46 54 L c

ATOM 5810 0 ASN L 158 20.536 2 390 -37 856 1.00 44 76 L 0

ATOM 5812 N SER L 159 19.167 4 159 -38 163 1.00 47 13 L N

ATOM 5813 CA SER L 159 19.371 4 698 -36 820 1.00 45 05 L c

ATOM 5815 CB SER L 159 20.460 5 784 -36 818 1.00 45 81 L c

ATOM 5818 OG SER L 159 20.039 6 947 -37 518 1.00 44 63 L 0

ATOM 5820 C SER L 159 18.069 5 259 -36 266 1.00 45 53 L c

ATOM 5821 0 SER L 159 17.188 5 657 -37 017 1.00 44 89 L 0 human fD_Fab

ATOM 5823 N GLN L 160 17. ,965 5. 263 -34. ,941 1.00 43. ,89 L N

ATOM 5824 CA GLN L 160 16. ,784 5. 723 -34. ,227 1.00 45. ,61 L C

ATOM 5826 CB GLN L 160 15. 902 4. 531 -33. ,790 1.00 48. ,08 L C

ATOM 5829 CG GLN L 160 14. ,876 4. 082 -34. ,842 1.00 46. ,87 L c

ATOM 5832 CD GLN L 160 13. ,954 2. 985 -34. ,335 1.00 52. ,11 L c

ATOM 5833 OEl GLN L 160 14. ,403 2. 058 -33. ,653 1.00 59. ,14 L 0

ATOM 5834 NE2 GLN L 160 12. ,660 3. 064 -34. ,684 1.00 48. ,67 L N

ATOM 5837 C GLN L 160 17. ,245 6. 502 -33. ,006 1.00 43. ,43 L c

ATOM 5838 O GLN L 160 18. ,210 6. 107 -32. ,362 1.00 43. ,47 L 0

ATOM 5840 N GLU L 161 16. 552 7. 601 -32. ,698 1.00 45. ,17 L N

ATOM 5841 CA GLU L 161 16. ,897 8. 450 -31. ,556 1.00 47. ,01 L c

ATOM 5843 CB GLU L 161 17. ,126 9. 906 -31. ,982 1.00 51. ,76 L c

ATOM 5846 CG GLU L 161 18. ,506 10. 225 -32. 587 1.00 59. ,99 L c

ATOM 5849 CD GLU L 161 18. ,745 9. 610 -33. ,986 1.00 65. ,42 L c

ATOM 5850 OEl GLU L 161 17. ,810 9. 604 -34. ,822 1.00 69. ,22 L 0

ATOM 5851 OE2 GLU L 161 19. ,880 9. 146 -34. 256 1.00 60. 47 L 0

ATOM 5852 C GLU L 161 15. ,813 8. 368 -30. ,479 1.00 46. 00 L c

ATOM 5853 O GLU L 161 14. ,678 7. 997 -30. 755 1.00 42. 86 L 0

ATOM 5855 N SER L 162 16. ,198 8. 705 -29. ,251 1.00 45. ,10 L N

ATOM 5856 CA SER L 162 15. 298 8. 748 -28. 114 1.00 44. ,83 L c

ATOM 5858 CB SER L 162 15. 228 7. 373 -27. 451 1.00 46. ,27 L c

ATOM 5861 OG SER L 162 14. ,185 7. 274 -26. ,504 1.00 43. ,36 L 0

ATOM 5863 C SER L 162 15. ,799 9. 795 -27. ,122 1.00 43. ,94 L c

ATOM 5864 O SER L 162 16. ,966 9. 769 -26. ,734 1.00 46. ,06 L 0

ATOM 5866 N VAL L 163 14. ,921 10. 725 -26. 725 1.00 43. ,34 L N

ATOM 5867 CA VAL L 163 15. 296 11. 819 -25. 824 1.00 41. 68 L c

ATOM 5869 CB VAL L 163 15. 111 13. 238 -26. ,477 1.00 44. ,89 L c

ATOM 5871 CGI VAL L 163 13. 646 13. 562 -26. ,676 1.00 48. ,73 L c

ATOM 5875 CG2 VAL L 163 15. 777 14. 337 -25. 627 1.00 38. ,36 L c

ATOM 5879 C VAL L 163 14. ,526 11. 717 -24. ,504 1.00 42. ,13 L c

ATOM 5880 O VAL L 163 13. ,341 11. 406 -24. ,485 1.00 44. ,76 L 0

ATOM 5882 N THR L 164 15. ,211 11. 963 -23. 393 1.00 44. ,51 L N

ATOM 5883 CA THR L 164 14. 553 11. 976 -22. ,100 1.00 44. ,55 L c

ATOM 5885 CB THR L 164 15. 540 11. 900 -20. ,934 1.00 44.16 L c

ATOM 5887 OGl THR L 164 16. 492 12. 990 -21. ,014 1.00 38. ,19 L 0

ATOM 5889 CG2 THR L 164 16. 235 10. 536 -20. ,925 1.00 43. ,45 L c

ATOM 5893 C THR L 164 13. 717 13. 232 -21. ,915 1.00 47. ,76 L c

ATOM 5894 O THR L 164 13. ,737 14. 157 -22. ,727 1.00 50. ,86 L 0

ATOM 5896 N GLU L 165 12. ,960 13. 248 -20. ,833 1.00 52. ,21 L N

ATOM 5897 CA GLU L 165 12. ,254 14. 451 -20. ,428 1.00 51. ,87 L c

ATOM 5899 CB GLU L 165 11. 068 14. 119 -19. ,503 1.00 60. ,15 L c

ATOM 5902 CG GLU L 165 9. ,868 13. 437 -20. ,186 1.00 66. ,90 L c

ATOM 5905 CD GLU L 165 9. ,178 14. 306 -21. ,239 1.00 73. ,87 L c

ATOM 5906 OEl GLU L 165 8. 988 15. 529 -21. ,004 1.00 79. ,27 L 0

ATOM 5907 OE2 GLU L 165 8. 812 13. 754 -22. ,303 1.00 75. ,01 L 0

ATOM 5908 C GLU L 165 13. 244 15. 350 -19. ,698 1.00 50. ,07 L c

ATOM 5909 O GLU L 165 14. ,286 14. 901 -19. ,214 1.00 53. ,11 L 0

ATOM 5911 N GLN L 166 12. ,910 16. 624 -19. ,626 1.00 45. ,02 L N

ATOM 5912 CA GLN L 166 13. ,731 17. 584 -18. ,914 1.00 45. ,55 L c

ATOM 5914 CB GLN L 166 13. ,024 18. 934 -18. ,865 1.00 42. ,82 L c

ATOM 5917 CG GLN L 166 13. ,969 20. 080 -18. 793 1.00 43. ,85 L c

ATOM 5920 CD GLN L 166 13. 334 21. 403 -19. ,131 1.00 40. ,52 L c

ATOM 5921 OEl GLN L 166 12. ,109 21. 538 -19. ,140 1.00 42, ,89 L 0

ATOM 5922 NE2 GLN L 166 14. 171 22. 404 -19. ,380 1.00 33. ,65 L N

ATOM 5925 C GLN L 166 14. ,019 17. 099 -17. ,489 1.00 48. ,19 L c

ATOM 5926 O GLN L 166 13. ,102 16. 667 -16. .771 1.00 49. .10 L 0

ATOM 5928 N ASP L 167 15. ,287 17. ,158 -17. ,089 1.00 48. .15 L N

ATOM 5929 CA ASP L 167 15. ,687 16. 704 -15. ,764 1.00 46. .60 L c

ATOM 5931 CB ASP L 167 17. ,209 16. 587 -15. ,628 1.00 45. ,82 L c

ATOM 5934 CG ASP L 167 17. 652 16. 256 -14. ,199 1.00 49. ,56 L c

ATOM 5935 ODl ASP L 167 17. ,188 15. 248 -13. ,635 1.00 56. ,20 L 0

ATOM 5936 OD2 ASP L 167 18. ,470 17. 003 -13. ,626 1.00 54. ,03 L 0

ATOM 5937 C ASP L 167 15. ,162 17. ,691 -14. ,739 1.00 48, .59 L c

ATOM 5938 O ASP L 167 15. 280 18. 906 -14. ,923 1.00 46, ,36 L 0

ATOM 5940 N SER L 168 14. 621 17. 146 -13. ,648 1.00 46, .59 L N

ATOM 5941 CA SER L 168 13. 940 17. ,930 -12. ,624 1.00 45, .21 L C

ATOM 5943 CB SER L 168 13. 069 17. 020 -11. ,760 1.00 48, ,94 L C

ATOM 5946 OG SER L 168 13. 855 16. 094 -11. ,027 1.00 57, ,06 L 0 human fD_Fab

ATOM 5948 C SER L 168 14. 882 18. ,721 -11. 726 1.00 44. ,11 L C

ATOM 5949 O SER L 168 14. 425 19. ,514 -10. ,908 1.00 45. ,25 L 0

ATOM 5951 N LYS L 169 16. ,186 18. 511 -11.864 1.00 47. ,10 L N

ATOM 5952 CA LYS L 169 17. 165 19. 268 -11. 091 1.00 49. ,10 L C

ATOM 5954 CB LYS L 169 18. ,125 18. ,333 -10. 345 1.00 55. ,10 L C

ATOM 5957 CG LYS L 169 17. ,483 17. .623 -9. ,161 1.00 57. ,75 L c

ATOM 5960 CD LYS L 169 18. ,397 16. ,526 -8. ,637 1.00 58. ,16 L c

ATOM 5963 CE LYS L 169 17. ,714 15. ,701 -7. 561 1.00 59. ,90 L c

ATOM 5966 NZ LYS L 169 18. 703 14. ,778 -6. ,933 1.00 63. ,16 L N

ATOM 5970 C LYS L 169 17. 959 20. ,247 -11. ,947 1.00 43. ,78 L c

ATOM 5971 O LYS L 169 18. ,130 21. ,390 -11. 551 1.00 44. ,75 L 0

ATOM 5973 N ASP L 170 18. ,470 19. 802 -13. 097 1.00 44. ,05 L N

ATOM 5974 CA ASP L 170 19. ,339 20. ,666 -13. 927 1.00 44. ,32 L c

ATOM 5976 CB ASP L 170 20. ,724 20. ,021 -14. 167 1.00 47. ,00 L c

ATOM 5979 CG ASP L 170 20. 682 18. ,777 -15. ,046 1.00 46. ,20 L c

ATOM 5980 ODl ASP L 170 19. ,688 18. ,527 -15. ,742 1.00 42. ,07 L 0

ATOM 5981 OD2 ASP L 170 21.686 18. ,038 -15. 053 1.00 52. ,35 L 0

ATOM 5982 C ASP L 170 18. 673 21. ,160 -15. 222 1.00 40. ,84 L c

ATOM 5983 O ASP L 170 19. ,236 21. ,940 -15. 956 1.00 41. ,42 L 0

ATOM 5985 N SER L 171 17. 462 20. ,695 -15. 464 1.00 37. ,12 L N

ATOM 5986 CA SER L 171 16. ,625 21. ,125 -16. ,584 1.00 38. ,72 L c

ATOM 5988 CB SER L 171 16. ,211 22. ,591 -16. 401 1.00 39. ,12 L c

ATOM 5991 OG SER L 171 15. 678 22. ,775 -15. 096 1.00 33. ,66 L 0

ATOM 5993 C SER L 171 17. 214 20. ,822 -17. 966 1.00 39. ,72 L c

ATOM 5994 O SER L 171 16. ,866 21.476 -18. ,950 1.00 41. ,10 L 0

ATOM 5996 N THR L 172 18. ,055 19. ,783 -18. ,032 1.00 43. ,50 L N

ATOM 5997 CA THR L 172 18. ,728 19. ,344 -19. 266 1.00 39. ,90 L c

ATOM 5999 CB THR L 172 20. ,180 18. ,920 -18. ,980 1.00 41. ,17 L c

ATOM 6001 OGl THR L 172 20. ,184 17. ,842 -18. 025 1.00 40. ,63 L 0

ATOM 6003 CG2 THR L 172 21. 025 20. ,095 -18. 463 1.00 35. ,88 L c

ATOM 6007 C THR L 172 18. ,052 18. ,122 -19. ,894 1.00 42. ,74 L c

ATOM 6008 O THR L 172 17. 285 17. ,416 -19. ,252 1.00 42. ,53 L 0

ATOM 6010 N TYR L 173 18. 348 17. ,890 -21.167 1.00 42. 60 L N

ATOM 6011 CA TYR L 173 17. ,907 16. ,689 -21. ,856 1.00 40. ,56 L c

ATOM 6013 CB TYR L 173 17. ,245 17. ,054 -23. ,187 1.00 44. 80 L c

ATOM 6016 CG TYR L 173 16. ,138 18. ,075 -23. ,038 1.00 45. ,06 L c

ATOM 6017 CDl TYR L 173 14. ,864 17. ,677 -22. ,702 1.00 45. ,05 L c

ATOM 6019 CEl TYR L 173 13. ,849 18. ,583 -22. ,532 1.00 45. ,91 L c

ATOM 6021 CZ TYR L 173 14. ,073 19. ,917 -22. ,703 1.00 44. ,80 L c

ATOM 6022 OH TYR L 173 13. ,001 20. ,768 -22. ,531 1.00 48. ,20 L 0

ATOM 6024 CE2 TYR L 173 15. ,334 20. .371 -23. ,049 1.00 47. ,48 L c

ATOM 6026 CD2 TYR L 173 16. ,370 19. ,437 -23. ,221 1.00 48. ,33 L c

ATOM 6028 C TYR L 173 19. ,125 15. .784 -22. ,072 1.00 42. ,57 L c

ATOM 6029 0 TYR L 173 20. ,297 16, .237 -22. ,036 1.00 40. ,79 L 0

ATOM 6031 N SER L 174 18. 841 14. .501 -22. ,259 1.00 39. ,04 L N

ATOM 6032 CA SER L 174 19. 820 13. .533 -22. .742 1.00 36. ,45 L c

ATOM 6034 CB SER L 174 20. 314 12. .601 -21.624 1.00 31. ,74 L c

ATOM 6037 OG SER L 174 21. 100 13. .321 -20. .671 1.00 32. ,50 L 0

ATOM 6039 C SER L 174 19. 176 12. ,760 -23. .886 1.00 36. ,73 L c

ATOM 6040 0 SER L 174 17. ,948 12. ,775 -24. ,056 1.00 37. ,78 L 0

ATOM 6042 N LEU L 175 20. ,024 12. ,137 -24. ,699 1.00 39. ,33 L N

ATOM 6043 CA LEU L 175 19. ,613 11. ,552 -25. ,970 1.00 38. ,72 L c

ATOM 6045 CB LEU L 175 19. ,675 12, .637 -27. .049 1.00 38, .96 L c

ATOM 6048 CG LEU L 175 19. ,280 12, .318 -28. .489 1.00 38. .52 L c

ATOM 6050 CDl LEU L 175 18. 662 13, .571 -29. .143 1.00 35. .68 L c

ATOM 6054 CD2 LEU L 175 20. ,457 11, ,791 -29. .304 1.00 30. ,92 L c

ATOM 6058 C LEU L 175 20. ,501 10, .350 -26. ,338 1.00 42. .27 L c

ATOM 6059 0 LEU L 175 21. ,727 10. .399 -26. ,223 1.00 38. ,62 L 0

ATOM 6061 N SER L 176 19. ,838 9. ,255 -26. .709 1.00 42. ,77 L N

ATOM 6062 CA SER L 176 20. ,474 8. .080 -27. .276 1.00 43. ,28 L c

ATOM 6064 CB SER L 176 19. ,888 6. .782 -26. .667 1.00 44. ,27 L c

ATOM 6067 OG SER L 176 18. ,646 6, ,397 -27. .270 1.00 43. .98 L 0

ATOM 6069 C SER L 176 20. ,239 8, .106 -28. ,779 1.00 44. .92 L c

ATOM 6070 0 SER L 176 19. ,189 8, .537 -29. ,237 1.00 48, ,72 L 0

ATOM 6072 N SER L 177 21. ,247 7, .697 -29. ,538 1.00 43, .83 L N

ATOM 6073 CA SER L 177 21. ,107 7, .417 -30. ,954 1.00 42. .60 L C

ATOM 6075 CB SER L 177 21. ,830 8. .466 -31.789 1.00 43, .91 L C

ATOM 6078 OG SER L 177 21. ,749 8, .163 -33. ,172 1.00 39, .89 L 0 human fD_Fab

ATOM 6080 C SER L 177 21.737 6. 056 -31. 189 1.00 44. 74 L C

ATOM 6081 O SER L 177 22.904 5. 843 -30. 842 1. 00 41. 52 L 0

ATOM 6083 N THR L 178 20.955 5. 143 -31. ,764 1.00 41. ,55 L N

ATOM 6084 CA THR L 178 21.367 3. 782 -31. 931 1. 00 41. ,36 L C

ATOM 6086 CB THR L 178 20.393 2. 815 -31. ,202 1.00 41. 23 L C

ATOM 6088 OGl THR L 178 20.117 3. 315 -29. 886 1.00 34. 82 L 0

ATOM 6090 CG2 THR L 178 20.993 1. 371 -31. 129 1.00 34. 06 L c

ATOM 6094 C THR L 178 21.437 3. 443 -33. 421 1. 00 42. 99 L c

ATOM 6095 O THR L 178 20.454 3. 574 -34. 149 1.00 41. 03 L 0

ATOM 6097 N LEU L 179 22.616 3. 014 -33. 855 1. 00 43. 56 L N

ATOM 6098 CA LEU L 179 22.823 2. 536 -35. ,213 1.00 42. ,23 L c

ATOM 6100 CB LEU L 179 24.224 2. 942 -35. 696 1.00 37. 76 L c

ATOM 6103 CG LEU L 179 24.612 2. 568 -37. 136 1.00 38. 89 L c

ATOM 6105 CDl LEU L 179 23.830 3. 419 -38. 129 1.00 28. 87 L c

ATOM 6109 CD2 LEU L 179 26.116 2. 724 -37. 362 1. 00 36. 34 L c

ATOM 6113 C LEU L 179 22.639 1. 018 -35. 217 1.00 44. 98 L c

ATOM 6114 O LEU L 179 23.266 0. 332 -34. 441 1. 00 42. 01 L 0

ATOM 6116 N THR L 180 21.765 0. 497 -36. ,070 1.00 48. 72 L N

ATOM 6117 CA THR L 180 21.556 -0. 957 -36. 150 1. 00 51. 44 L C

ATOM 6119 CB THR L 180 20.061 -1. 349 -36. 015 1.00 55. 20 L c

ATOM 6121 OGl THR L 180 19.538 -0. 795 -34. 805 1. 00 58. 87 L 0

ATOM 6123 CG2 THR L 180 19.872 -2. 895 -36. 003 1.00 50. 58 L c

ATOM 6127 C THR L 180 22.109 -1. 501 -37. 459 1. 00 52. 06 L c

ATOM 6128 O THR L 180 21.690 -1. 077 -38. 532 1.00 52. 76 L 0

ATOM 6130 N LEU L 181 23.049 -2. 438 -37. 338 1. 00 54. 81 L N

ATOM 6131 CA LEU L 181 23.693 -3. 115 -38. 475 1.00 55. 33 L c

ATOM 6133 CB LEU L 181 25.184 -2. 794 -38. 547 1.00 51. 09 L c

ATOM 6136 CG LEU L 181 25.657 -1. 358 -38. 624 1.00 48. 89 L c

ATOM 6138 CDl LEU L 181 27.144 -1. 361 -38. 469 1.00 47. 10 L c

ATOM 6142 CD2 LEU L 181 25.235 -0. 701 -39. 933 1.00 50. 67 L c

ATOM 6146 C LEU L 181 23.594 -4. 611 -38. 283 1.00 56. 24 L c

ATOM 6147 0 LEU L 181 23.395 -5. 086 -37. 162 1. 00 57. 83 L 0

ATOM 6149 N SER L 182 23.773 -5. 340 -39. 380 1.00 58. 64 L N

ATOM 6150 CA SER L 182 24.001 -6. 777 -39. ,324 1. 00 58. 26 L c

ATOM 6152 CB SER L 182 23.884 -7. 392 -40. 727 1.00 60. 68 L c

ATOM 6155 OG SER L 182 24.829 -6. 842 -41. 642 1.00 60. 85 L 0

ATOM 6157 C SER L 182 25.391 -7. 009 -38. 765 1.00 57. 29 L c

ATOM 6158 0 SER L 182 26.250 -6. 128 -38. 861 1. 00 57. 42 L 0

ATOM 6160 N LYS L 183 25.630 -8. 182 -38. 193 1.00 60. 44 L N

ATOM 6161 CA LYS L 183 26.990 -8. 564 -37. 806 1. 00 61. 38 L c

ATOM 6163 CB LYS L 183 26.995 -9. 939 -37. 139 1.00 63. 73 L c

ATOM 6166 CG LYS L 183 28.310 -10. ,287 -36. ,456 1. 00 62. ,64 L c

ATOM 6169 CD LYS L 183 28.448 -11. 773 -36. 254 1.00 63. ,18 L c

ATOM 6172 CE LYS L 183 29.728 -12. 117 -35. ,513 1.00 63. 65 L c

ATOM 6175 NZ LYS L 183 29.576 -13. 442 -34. 867 1.00 65. 34 L N

ATOM 6179 C LYS L 183 27.904 -8. 583 -39. 035 1.00 60. 83 L c

ATOM 6180 0 LYS L 183 29.055 -8. 163 -38. 977 1.00 61. 17 L 0

ATOM 6182 N ALA L 184 27.369 -9. 074 -40. 148 1. 00 62. 89 L N

ATOM 6183 CA ALA L 184 28.083 -9. 086 -41. ,427 1.00 62. ,19 L c

ATOM 6185 CB ALA L 184 27.159 -9. ,599 -42. 540 1.00 64. 64 L c

ATOM 6189 C ALA L 184 28.632 -7. 715 -41. 805 1. 00 61. 48 L c

ATOM 6190 0 ALA L 184 29.827 -7. 566 -42. 055 1.00 62. 53 L 0

ATOM 6192 N ASP L 185 27.752 -6. 717 -41. 851 1. 00 64. 33 L N

ATOM 6193 CA ASP L 185 28.145 -5. 343 -42. 204 1.00 60. 71 L C

ATOM 6195 CB ASP L 185 26.911 -4. 468 -42. 446 1.00 65. 03 L C

ATOM 6198 CG ASP L 185 26.152 -4. 843 -43. 711 1. 00 69. 12 L c

ATOM 6199 ODl ASP L 185 26.584 -5. 780 -44. ,420 1.00 72. ,16 L 0

ATOM 6200 002 ASP L 185 25.115 -4. ,196 -43. ,996 1. 00 68. 56 L 0

ATOM 6201 C ASP L 185 29.018 -4. 693 -41. ,134 1.00 56. ,36 L c

ATOM 6202 0 ASP L 185 29.933 -3. 959 -41. ,442 1.00 58. 96 L 0

ATOM 6204 N TYR L 186 28.737 -4. 956 -39. ,870 1. 00 56. ,41 L N

ATOM 6205 CA TYR L 186 29.546 -4. 393 -38. ,813 1.00 55. 71 L c

ATOM 6207 CB TYR L 186 28.992 -4. 733 -37. 448 1.00 49. 93 L c

ATOM 6210 CG TYR L 186 29.892 -4. 204 -36. 367 1.00 48. ,78 L c

ATOM 6211 CDl TYR L 186 29.974 -2. ,841 -36. ,116 1.00 45. ,08 L c

ATOM 6213 CEl TYR L 186 30.814 -2. ,347 -35. ,140 1.00 47. ,94 L c

ATOM 6215 CZ TYR L 186 31.590 -3. ,220 -34. ,417 1. 00 46. ,40 L c

ATOM 6216 OH TYR L 186 32.428 -2. 758 -33. ,436 1.00 47. 87 L 0 human fD_Fab

ATOM 6218 CE2 TYR L 186 31. ,525 -4. 574 -34. 658 1.00 48. 48 L C

ATOM 6220 CD2 TYR L 186 30. .693 -5. 056 -35. ,634 1.00 45. ,30 L C

ATOM 6222 C TYR L 186 30. 999 -4. 851 -38. 897 1.00 55. ,83 L c

ATOM 6223 O TYR L 186 31. ,918 -4. 023 -38. 794 1.00 52. ,78 L 0

ATOM 6225 N GLU L 187 31. 199 -6. 163 -39. 071 1.00 61. 69 L N

ATOM 6226 CA GLU L 187 32. ,544 -6. 756 -39. 189 1.00 63. 09 L c

ATOM 6228 CB GLU L 187 32. ,489 -8. 284 -39. 012 1.00 65. 43 L c

ATOM 6231 CG GLU L 187 31. 922 -8. 793 -37. 681 1.00 69. 71 L c

ATOM 6234 CD GLU L 187 32. ,804 -8. 500 -36. 471 1.00 75. ,45 L c

ATOM 6235 OEl GLU L 187 33. 938 -8. 003 -36. 632 1.00 80. 50 L 0

ATOM 6236 OE2 GLU L 187 32. 362 -8. 780 -35. 335 1.00 78. 84 L 0

ATOM 6237 C GLU L 187 33. 232 -6. 445 -40. 527 1.00 63. 09 L c

ATOM 6238 O GLU L 187 34. 419 -6. 726 -40. 700 1.00 62. 81 L 0

ATOM 6240 N LYS L 188 32. 479 -5. 875 -41. 464 1.00 64. 28 L N

ATOM 6241 CA LYS L 188 32. 996 -5. 466 -42. 761 1.00 64. 00 L c

ATOM 6243 CB LYS L 188 31. 829 -5. 454 -43. 754 1.00 66. ,06 L c

ATOM 6246 CG LYS L 188 32. 193 -5. 251 -45. 202 1.00 69. 06 L c

ATOM 6249 CD LYS L 188 30. 950 -5. 423 -46. 080 1.00 71. 62 L c

ATOM 6252 CE LYS L 188 31. 143 -4. 797 -47. 471 1.00 72. 63 L c

ATOM 6255 NZ LYS L 188 29. 927 -4. 957 -48. 333 1.00 72. 31 L N

ATOM 6259 C LYS L 188 33. 692 -4. 089 -42. 706 1.00 64. 42 L c

ATOM 6260 O LYS L 188 34. 561 -3. 803 -43. 533 1.00 67. 92 L 0

ATOM 6262 N HIS L 189 33. 331 -3. 251 -41.730 1.00 59. ,52 L N

ATOM 6263 CA HIS L 189 33. 865 -1. 878 -41. 644 1.00 57. 93 L c

ATOM 6265 CB HIS L 189 32. 727 -0. 867 -41. 847 1.00 54. 63 L c

ATOM 6268 CG HIS L 189 31. 967 -1. 072 -43. 124 1.00 53. 62 L c

ATOM 6269 NDl HIS L 189 32. 411 -0. 602 -44. 340 1.00 55. 10 L N

ATOM 6271 CEl HIS L 189 31.551 -0. 943 -45. 285 1.00 54. 65 L C

ATOM 6273 NE2 HIS L 189 30. 564 -1. 620 -44. 726 1.00 54. 19 L N

ATOM 6275 CD 2 HIS L 189 30. 803 -1. 721 -43. 377 1.00 54. ,45 L C

ATOM 6277 C HIS L 189 34. 647 -1. 602 -40. 353 1.00 55. 08 L c

ATOM 6278 0 HIS L 189 34. 524 -2. 331 -39. 377 1.00 50. 86 L 0

ATOM 6280 N LYS L 190 35. 462 -0. 548 -40. 375 1.00 60. 20 L N

ATOM 6281 CA LYS L 190 36. 428 -0. 245 -39. 306 1.00 61.70 L c

ATOM 6283 CB LYS L 190 37. 794 0. 046 -39. 946 1.00 65. 45 L c

ATOM 6286 CG LYS L 190 38. 980 0. 269 -38. 985 1.00 66. 68 L c

ATOM 6289 CD LYS L 190 40. 202 0. 796 -39. 768 1.00 67. 88 L c

ATOM 6292 CE LYS L 190 41. 533 0. 617 -39. 024 1.00 70. ,59 L c

ATOM 6295 NZ LYS L 190 41. 881 1. 774 -38. 144 1.00 72. 68 L N

ATOM 6299 C LYS L 190 36. 003 0. 946 -38. 433 1.00 60. 27 L c

ATOM 6300 0 LYS L 190 35. 963 0. 841 -37. 209 1.00 61. 09 L 0

ATOM 6302 N VAL L 191 35. 693 2. 075 -39. 065 1.00 58. 06 L N

ATOM 6303 CA VAL L 191 35. 486 3. 328 -38. 335 1.00 56. 13 L C

ATOM 6305 CB VAL L 191 36. 163 4. 531 -39. 022 1.00 51. 38 L C

ATOM 6307 CGl VAL L 191 36. 327 5. 666 -38. ,035 1.00 44. ,91 L c

ATOM 6311 CG2 VAL L 191 37. 511 4. 133 -39. 618 1.00 46. ,86 L c

ATOM 6315 C VAL L 191 34. 012 3. 639 -38. 169 1.00 54. 00 L c

ATOM 6316 0 VAL L 191 33. 294 3. 803 -39. 141 1.00 51. 82 L 0

ATOM 6318 N TYR L 192 33. 579 3. 721 -36. 916 1.00 53. 06 L N

ATOM 6319 CA TYR L 192 32. 207 4. 051 -36. 589 1.00 52. 43 L c

ATOM 6321 CB TYR L 192 31. 590 2. 913 -35. 749 1.00 48. 27 L c

ATOM 6324 CG TYR L 192 31. 431 1. 670 -36. ,585 1.00 43. ,89 L c

ATOM 6325 CDl TYR L 192 30. 263 1. 442 -37. ,294 1.00 46. ,86 L c

ATOM 6327 CEl TYR L 192 30. 122 0. 337 -38. ,106 1.00 45. ,64 L c

ATOM 6329 CZ TYR L 192 31. 166 -0. 548 -38. 234 1.00 46. ,11 L c

ATOM 6330 OH TYR L 192 31. 008 -1. 649 -39. 054 1.00 46. ,65 L 0

ATOM 6332 CE2 TYR L 192 32. 343 -0. 336 -37. 551 1.00 43. ,77 L c

ATOM 6334 CD2 TYR L 192 32. 472 0. 775 -36. 736 1.00 41.79 L c

ATOM 6336 C TYR L 192 32. 211 5. 390 -35. 883 1.00 49. ,70 L c

ATOM 6337 0 TYR L 192 32. 914 5. 575 -34. 895 1.00 47. ,81 L 0

ATOM 6339 N ALA L 193 31. 453 6. 333 -36. ,426 1.00 45. ,97 L N

ATOM 6340 CA ALA L 193 31. 540 7. 703 -35. 986 1.00 49. ,30 L c

ATOM 6342 CB ALA L 193 32. 350 8. 542 -37. 023 1.00 42. ,40 L c

ATOM 6346 C ALA L 193 30. 168 8. 300 -35. 769 1.00 49. 30 L c

ATOM 6347 0 ALA L 193 29. 250 8. 107 -36. 567 1.00 47. ,78 L 0

ATOM 6349 N CYS L 194 30. 070 9. 035 -34. ,670 1.00 51. ,14 L N

ATOM 6350 CA CYS L 194 28. 875 9. 749 -34. 262 1.00 50. ,14 L c

ATOM 6352 CB CYS L 194 28. 528 9. 329 -32. 835 1.00 50. 26 L c human fD_Fab

ATOM 6355 SG CYS L 194 27. 025 9. 988 -32. 355 1. 00 54. 32 L S

ATOM 6357 C CYS L 194 29. 142 11. 250 -34. 268 1. 00 48. 33 L C

ATOM 6358 O CYS L 194 29. 904 11.729 -33. 444 1. 00 46. ,40 L 0

ATOM 6360 N GLU L 195 28. 507 11. 988 -35. 178 1. 00 50. ,19 L N

ATOM 6361 CA GLU L 195 28. ,655 13. ,446 -35. 254 1. 00 50. .14 L C

ATOM 6363 CB GLU L 195 28. 828 13. ,904 -36. 705 1. 00 49. ,47 L C

ATOM 6366 CG GLU L 195 29. ,442 15. 296 -36. 815 1. 00 50. ,72 L C

ATOM 6369 CD GLU L 195 29. ,484 15. ,846 -38. 241 1. 00 53. ,94 L C

ATOM 6370 OEl GLU L 195 28. 487 15. 645 -38. 972 1. 00 56. ,27 L 0

ATOM 6371 OE2 GLU L 195 30. 499 16. 507 -38. 606 1. 00 46. ,08 L 0

ATOM 6372 C GLU L 195 27. 472 14. 192 -34. 665 1. 00 47. ,54 L C

ATOM 6373 O GLU L 195 26. 365 14. 007 -35. 117 1. 00 47. ,84 L 0

ATOM 6375 N VAL L 196 27. ,726 15. ,087 -33. 709 1. 00 49. ,17 L N

ATOM 6376 CA VAL L 196 26. ,661 15. ,799 -32. 969 1. 00 45. ,93 L C

ATOM 6378 CB VAL L 196 26. 742 15. 500 -31.439 1. 00 42. 68 L c

ATOM 6380 CGI VAL L 196 25. 766 16. ,376 -30. 603 1. 00 34. 28 L c

ATOM 6384 CG2 VAL L 196 26. 488 14. ,019 -31.189 1. 00 42. 50 L c

ATOM 6388 C VAL L 196 26. 688 17. 311 -33. 193 1. 00 45. 66 L c

ATOM 6389 O VAL L 196 27. 691 17. 954 -32. 922 1. 00 46. 99 L 0

ATOM 6391 N THR L 197 25. 570 17. 856 -33. 670 1. 00 46. ,91 L N

ATOM 6392 CA THR L 197 25. 362 19. 301 -33. 844 1. 00 46. ,84 L c

ATOM 6394 CB THR L 197 24. 759 19. ,615 -35. 230 1. 00 43. ,17 L c

ATOM 6396 OGl THR L 197 25. 604 19. 073 -36. 249 1. 00 44. ,87 L 0

ATOM 6398 CG2 THR L 197 24. 610 21. ,110 -35. 446 1. 00 39. 93 L c

ATOM 6402 C THR L 197 24. 390 19. 829 -32. 793 1. 00 45. 99 L c

ATOM 6403 O THR L 197 23. 282 19. 331 -32. 647 1. 00 44. 32 L 0

ATOM 6405 N HIS L 198 24. 815 20. 850 -32. 072 1. 00 48. ,27 L N

ATOM 6406 CA HIS L 198 24. 017 21.421 -31. 002 1. 00 48. ,02 L c

ATOM 6408 CB HIS L 198 24. 192 20. 569 -29. 726 1. 00 46. ,41 L c

ATOM 6411 CG HIS L 198 23. 401 21. 048 -28. 552 1. 00 44. ,30 L c

ATOM 6412 NDl HIS L 198 22. 071 20. ,738 -28. 372 1. 00 44. ,95 L N

ATOM 6414 CEl HIS L 198 21. 637 21. 315 -27. 266 1. 00 43. ,07 L c

ATOM 6416 NE2 HIS L 198 22. 638 21.975 -26. 715 1. 00 41.43 L N

ATOM 6418 CD2 HIS L 198 23. 755 21. 817 -27. 496 1. 00 42. ,19 L C

ATOM 6420 C HIS L 198 24. 491 22. 840 -30. 796 1. 00 49. ,58 L C

ATOM 6421 O HIS L 198 25. 663 23. 118 -30. 993 1. 00 52. ,10 L 0

ATOM 6423 N GLN L 199 23. 574 23. 722 -30. 411 1. 00 49. ,49 L N

ATOM 6424 CA GLN L 199 23. 859 25. ,135 -30. 177 1. 00 49. ,77 L C

ATOM 6426 CB GLN L 199 22. 595 25. ,815 -29. 631 1. 00 51. ,64 L C

ATOM 6429 CG GLN L 199 22. 779 27. 305 -29. 347 1. 00 51. ,76 L C

ATOM 6432 CD GLN L 199 21. 484 28. ,016 -29. 048 1. 00 53. ,94 L C

ATOM 6433 OEl GLN L 199 20. 443 27. 395 -28. 772 1. 00 50. ,61 L 0

ATOM 6434 NE2 GLN L 199 21. 539 29. 340 -29. 092 1. 00 56. ,38 L N

ATOM 6437 C GLN L 199 25. 038 25. 400 -29. 219 1. 00 49. ,16 L C

ATOM 6438 0 GLN L 199 25. 795 26. 351 -29. 394 1. 00 50. ,99 L 0

ATOM 6440 N GLY L 200 25. 169 24. 561 -28. 202 1. 00 46. ,70 L N

ATOM 6441 CA GLY L 200 26. 245 24. ,667 -27. 213 1. 00 46. ,48 L C

ATOM 6444 C GLY L 200 27. 595 24. ,140 -27. 688 1. 00 47. ,59 L C

ATOM 6445 O GLY L 200 28. 585 24. ,217 -26. 958 1. 00 46. ,17 L 0

ATOM 6447 N LEU L 201 27. 641 23. ,610 -28. 911 1. 00 48, ,45 L N

ATOM 6448 CA LEU L 201 28. 898 23. 232 -29. 550 1. 00 50. ,95 L C

ATOM 6450 CB LEU L 201 28. 810 21. ,819 -30. 115 1. 00 48. ,31 L c

ATOM 6453 CG LEU L 201 28. 481 20. 691 -29. 160 1. 00 42. ,30 L c

ATOM 6455 CDl LEU L 201 28. 103 19. 460 -29. 959 1. 00 41. ,86 L c

ATOM 6459 CD2 LEU L 201 29. 648 20. ,441 -28. 261 1. 00 38. .77 L c

ATOM 6463 C LEU L 201 29. 186 24. ,184 -30. 698 1. 00 51. ,33 L c

ATOM 6464 O LEU L 201 28. 361 24. ,312 -31. 613 1. 00 48. ,35 L 0

ATOM 6466 N SER L 202 30. 353 24. ,826 -30. 653 1. 00 54. ,52 L N

ATOM 6467 CA SER L 202 30. 753 25. 833 -31. 649 1. 00 56. ,76 L c

ATOM 6469 CB SER L 202 32. 178 26. ,306 -31. 359 1. 00 50. ,69 L c

ATOM 6472 OG SER L 202 32. 286 26. ,758 -30. 036 1. 00 48. ,46 L 0

ATOM 6474 C SER L 202 30. 682 25. 290 -33. 075 1. 00 59. ,76 L c

ATOM 6475 O SER L 202 30. 073 25. ,907 -33. 947 1. 00 58. .24 L 0

ATOM 6477 N SER L 203 31. 340 24. ,151 -33. 288 1. 00 59. .72 L N

ATOM 6478 CA SER L 203 31. 172 23. 329 -34. 480 1. 00 57. .86 L c

ATOM 6480 CB SER L 203 32. 460 23. 267 -35. 291 1. 00 50. ,95 L c

ATOM 6483 OG SER L 203 32. 819 24. 548 -35. 726 1. 00 50. ,17 L 0

ATOM 6485 C SER L 203 30. 794 21. 913 -34. 050 1. 00 58. ,51 L c human fD_Fab

ATOM 6486 O SER L 203 31. 028 21 541 -32 898 1 00 57 05 L 0

ATOM 6488 N PRO L 204 30. 222 21 114 -34 976 1 00 57 55 L N

ATOM 6489 CA PRO L 204 29. 888 19 718 -34 701 1 00 57 91 L C

ATOM 6491 CB PRO L 204 29. 421 19 194 -36 067 1 00 55 27 L C

ATOM 6494 CG PRO L 204 28. 949 20 355 -36. 772 1 00 53 04 L C

ATOM 6497 CD PRO L 204 29. 826 21 490 -36 344 1 00 53 32 L c

ATOM 6500 C PRO L 204 31. 043 18 841 -34 156 1 00 59 00 L c

ATOM 6501 O PRO L 204 32. 135 18 794 -34 721 1 00 60 86 L 0

ATOM 6502 N VAL L 205 30. 756 18 137 -33 064 1 00 58 39 L N

ATOM 6503 CA VAL L 205 31. 703 17 223 -32 418 1 00 55 63 L c

ATOM 6505 CB VAL L 205 31. 570 17 320 -30 866 1 00 53 31 L C

ATOM 6507 CGI VAL L 205 32. 248 16 153 -30 154 1 00 46 49 L C

ATOM 6511 CG2 VAL L 205 32. 124 18 650 -30 376 1 00 50 74 L c

ATOM 6515 C VAL L 205 31. 440 15 783 -32. 885 1 00 55 29 L c

ATOM 6516 O VAL L 205 30. 293 15 340 -32. 924 1 00 57 28 L 0

ATOM 6518 N THR L 206 32 . 509 15 082 -33 254 1 00 54 15 L N

ATOM 6519 CA THR L 206 32. 449 13 684 -33 657 1 00 51 32 L C

ATOM 6521 CB THR L 206 33 . 160 13 409 -34 991 1 00 53 60 L C

ATOM 6523 OGl THR L 206 32. 382 13 946 -36 062 1 00 56 63 L 0

ATOM 6525 CG2 THR L 206 33. 318 11 908 -35 225 1 00 53 34 L C

ATOM 6529 C THR L 206 33. 083 12 830 -32 575 1 00 48 30 L c

ATOM 6530 O THR L 206 34. 101 13 182 -32. 003 1 00 44 93 L 0

ATOM 6532 N LYS L 207 32. 438 11 711 -32. 278 1 00 48 11 L N

ATOM 6533 CA LYS L 207 32 . 951 10 746 -31. 328 1 00 47 69 L c

ATOM 6535 CB LYS L 207 32 . 017 10 661 -30 130 1 00 51 27 L c

ATOM 6538 CG LYS L 207 32 . 591 9 963 -28 938 1 00 54 80 L c

ATOM 6541 CD LYS L 207 33. 522 10 856 -28 161 1 00 56 35 L c

ATOM 6544 CE LYS L 207 34. 129 10 089 -26 983 1 00 57 99 L c

ATOM 6547 NZ LYS L 207 35. 075 10 969 -26 211 1 00 61 14 L N

ATOM 6551 C LYS L 207 32 . 995 9 447 -32 091 1 00 45 20 L c

ATOM 6552 O LYS L 207 32. 029 9 100 -32. 736 1 00 45 83 L 0

ATOM 6554 N SER L 208 34. 120 8 742 -32. 062 1 00 46 22 L N

ATOM 6555 CA SER L 208 34. 236 7 531 -32. 871 1 00 47 63 L c

ATOM 6557 CB SER L 208 34. 666 7 878 -34 302 1 00 47 55 L c

ATOM 6560 OG SER L 208 36. 033 8 220 -34 384 1 00 41 56 L 0

ATOM 6562 C SER L 208 35. 180 6 500 -32 288 1 00 48 20 L c

ATOM 6563 O SER L 208 35 . 934 6 777 -31 362 1 00 52 20 L 0

ATOM 6565 N PHE L 209 35 . 101 5 296 -32 831 1 00 46 66 L N

ATOM 6566 CA PHE L 209 36. 035 4 233 -32 502 1 00 49 44 L c

ATOM 6568 CB PHE L 209 35 . 432 3 330 -31.420 1 00 46 41 L c

ATOM 6571 CG PHE L 209 34. 239 2 542 -31 880 1 00 46 64 L c

ATOM 6572 CDl PHE L 209 34. 398 1 286 -32 450 1 00 43 56 L c

ATOM 6574 CEl PHE L 209 33. 311 0 548 -32 865 1 00 42 13 L c

ATOM 6576 CZ PHE L 209 32. 052 1 059 -32 721 1 00 44 04 L c

ATOM 6578 CE2 PHE L 209 31. 870 2 314 -32 161 1 00 46 14 L c

ATOM 6580 CD2 PHE L 209 32. 956 3 047 -31 732 1 00 46 76 L c

ATOM 6582 C PHE L 209 36. 341 3 409 -33 743 1 00 49 20 L c

ATOM 6583 0 PHE L 209 35. 588 3 448 -34 719 1 00 46 78 L 0

ATOM 6585 N ASN L 210 37. 426 2 640 -33 688 1 00 51 35 L N

ATOM 6586 CA ASN L 210 37. 718 1 629 -34 720 1 00 52 39 L c

ATOM 6588 CB ASN L 210 39. 204 1 572 -35 066 1 00 52 66 L c

ATOM 6591 CG ASN L 210 39. 697 2 814 -35 753 1 00 51 88 L c

ATOM 6592 ODl ASN L 210 40. 616 3 464 -35 271 1 00 49 14 L 0

ATOM 6593 ND2 ASN L 210 39. 092 3 154 -36 891 1 00 53 74 L N

ATOM 6596 C ASN L 210 37. 294 0 250 -34 228 1 00 52 59 L c

ATOM 6597 0 ASN L 210 37. 520 -0 089 -33 074 1 00 50 71 L 0

ATOM 6599 N ARG L 211 36. 684 -0 546 -35 096 1 00 55 47 L N

ATOM 6600 CA ARG L 211 36. 206 -1 863 -34 702 1 00 58 50 L c

ATOM 6602 CB ARG L 211 35 . 549 -2 581 -35 880 1 00 57 44 L c

ATOM 6605 CG ARG L 211 34. 993 -3 961 -35 512 1 00 55 24 L c

ATOM 6608 CD ARG L 211 34. 199 -4 594 -36 649 1 00 56 18 L c

ATOM 6611 NE ARG L 211 34. 885 -4 525 -37 935 1 00 60 69 L N

ATOM 6613 CZ ARG L 211 36. 031 -5 152 -38 235 1 00 60 74 L c

ATOM 6614 NHl ARG L 211 36. 646 -5 936 -37 352 1 00 58 37 L N

ATOM 6617 NH2 ARG L 211 36. 570 -4 991 -39 443 1 00 55 17 L N

ATOM 6620 C ARG L 211 37. 376 -2 679 -34 158 1 00 63 88 L c

ATOM 6621 0 ARG L 211 38. 414 -2 808 -34 814 1 00 61 01 L 0

ATOM 6623 N GLY L 212 37. 162 -3 266 -32 980 1 00 71 67 L N human fD_Fab

ATOM 6624 CA GLY L 212 38.233 -3. 558 -32. 025 1.00 78. ,82 L C

ATOM 6627 C GLY L 212 38.122 -2. 433 -31. 015 1.00 85. ,15 L C

ATOM 6628 O GLY L 212 37.028 -1. 892 -30. 840 1.00 89. ,78 L 0

ATOM 6630 N GLU L 213 39.221 -2. 066 -30. 357 1.00 87. ,23 L N

ATOM 6631 CA GLU L 213 39.267 -0. 853 -29. ,493 1.00 87. ,94 L C

ATOM 6633 CB GLU L 213 39.310 0. 415 -30. 349 1.00 87. ,71 L C

ATOM 6636 CG GLU L 213 40.434 0. 514 -31. 355 1.00 86. ,45 L C

ATOM 6639 CD GLU L 213 40.584 1. 929 -31. 898 1.00 84. 96 L c

ATOM 6640 OEl GLU L 213 39.728 2. 794 -31. 599 1.00 80. ,72 L 0

ATOM 6641 OE2 GLU L 213 41.559 2. 168 -32. 633 1.00 83. 00 L 0

ATOM 6642 C GLU L 213 38.089 -0. 655 -28. 506 1.00 89. ,34 L c

ATOM 6643 O GLU L 213 36.944 -0. 930 -28. 844 1.00 88. ,75 L 0

ATOM 6645 N CYS L 214 38.358 -0. 117 -27. 313 1.00 88. ,21 L N

ATOM 6646 CA CYS L 214 37.330 0. 005 -26. 256 1.00 88. 02 L c

ATOM 6648 CB CYS L 214 37.737 -0. 738 -24. 973 1.00 88. ,17 L c

ATOM 6651 SG CYS L 214 38.487 -2. 372 -25. 224 1.00 87. 90 L S

ATOM 6653 C CYS L 214 37.054 1. 467 -25. 929 1.00 87. 94 L c

ATOM 6654 O CYS L 214 37.836 2. 119 -25. 236 1.00 87. 27 L 0

ATOM 6656 N GLU H 1 -2.069 3. 119 6. 492 1.00 44. ,41 H N

ATOM 6657 CA GLU H 1 -2.053 4. 100 5. 359 1.00 46. 29 H c

ATOM 6659 CB GLU H 1 -0.634 4. 500 4. 954 1.00 46. ,98 H c

ATOM 6662 CG GLU H 1 0.037 3. 605 3. 923 1.00 50. ,56 H c

ATOM 6665 CD GLU H 1 0.350 2. 212 4. 415 1.00 50. ,71 H c

ATOM 6666 OEl GLU H 1 0.116 1. 878 5. 612 1.00 47. ,53 H 0

ATOM 6667 OE2 GLU H 1 0.830 1. 440 3. 566 1.00 54. 91 H 0

ATOM 6668 C GLU H 1 -2.853 3. 592 4. 156 1.00 47. 06 H c

ATOM 6669 O GLU H 1 -3.028 2. 398 3. 968 1.00 47. 23 H 0

ATOM 6673 N VAL H 2 -3.341 4. 522 3. 340 1.00 48. ,38 H N

ATOM 6674 CA VAL H 2 -4.169 4. 166 2. 196 1.00 41. ,58 H c

ATOM 6676 CB VAL H 2 -5.126 5. 328 1. 775 1.00 39. 99 H c

ATOM 6678 CGI VAL H 2 -5.920 4. 969 0. 502 1.00 37. 91 H c

ATOM 6682 CG2 VAL H 2 -6.081 5. 700 2. 925 1.00 36. 96 H c

ATOM 6686 C VAL H 2 -3.267 3. 725 1. 053 1.00 41. 29 H c

ATOM 6687 O VAL H 2 -2.196 4. 330 0. 801 1.00 38. 23 H 0

ATOM 6689 N GLN H 3 -3.697 2. 653 0. ,389 1.00 39. 72 H N

ATOM 6690 CA GLN H 3 -3.020 2. 111 -0. 788 1.00 40. 63 H c

ATOM 6692 CB GLN H 3 -2.121 0. 929 -0. 386 1.00 41. 89 H c

ATOM 6695 CG GLN H 3 -1.071 1. 275 0. 639 1.00 45. 64 H c

ATOM 6698 CD GLN H 3 -0.044 2. 270 0. 104 1.00 47. 09 H c

ATOM 6699 OEl GLN H 3 0.014 2. 553 -1. 107 1.00 47. 60 H 0

ATOM 6700 NE2 GLN H 3 0.766 2. 810 1. ,005 1.00 39. ,17 H N

ATOM 6703 C GLN H 3 -4.057 1. 618 -1. 816 1.00 37. ,05 H c

ATOM 6704 O GLN H 3 -5.119 1. 080 -1. ,451 1.00 36. 65 H 0

ATOM 6706 N LEU H 4 -3.716 1. 799 -3. 083 1.00 33. 69 H N

ATOM 6707 CA LEU H 4 -4.460 1. 265 -4. 193 1.00 35. ,71 H c

ATOM 6709 CB LEU H 4 -5.228 2. 383 -4. 921 1.00 38. 38 H c

ATOM 6712 CG LEU H 4 -6.286 3. 156 -4. 113 1.00 32. 18 H c

ATOM 6714 CDl LEU H 4 -6.875 4. 315 -4. 936 1.00 33. 93 H c

ATOM 6718 CD2 LEU H 4 -7.400 2. 258 -3. ,677 1.00 35. 29 H c

ATOM 6722 C LEU H 4 -3.445 0. 589 -5. ,112 1.00 34. 33 H c

ATOM 6723 O LEU H 4 -2.504 1. 229 -5. 599 1.00 34. ,20 H 0

ATOM 6725 N VAL H 5 -3.600 -0. 719 -5. ,293 1.00 34. ,00 H N

ATOM 6726 CA VAL H 5 -2.628 -1. 512 -6. ,008 1.00 35. 22 H c

ATOM 6728 CB VAL H 5 -1.968 -2. 536 -5. ,040 1.00 33. 57 H c

ATOM 6730 CGI VAL H 5 -1.056 -3. 515 -5. 810 1.00 32. 11 H c

ATOM 6734 CG2 VAL H 5 -1.187 -1. 781 -3. ,956 1.00 31.13 H c

ATOM 6738 C VAL H 5 -3.356 -2. 204 -7. 146 1.00 37. ,40 H c

ATOM 6739 O VAL H 5 -4.295 -2. 962 -6. 891 1.00 39. ,10 H 0

ATOM 6741 N GLN H 6 -2.933 -1. 914 -8. 379 1.00 36. ,95 H N

ATOM 6742 CA GLN H 6 -3.536 -2. 451 -9. 562 1.00 38. ,93 H c

ATOM 6744 CB GLN H 6 -3.671 -1. 341 -10. 615 1.00 44. 00 H c

ATOM 6747 CG GLN H 6 -4.609 -0. 174 -10. 223 1.00 39. 67 H c

ATOM 6750 CD GLN H 6 -4.610 0. 916 -11. ,276 1.00 38. ,07 H c

ATOM 6751 OEl GLN H 6 -4.106 2. 031 -11. 066 1.00 33. ,97 H 0

ATOM 6752 NE2 GLN H 6 -5.152 0. 594 -12. ,425 1.00 39. ,45 H N

ATOM 6755 C GLN H 6 -2.742 -3. 651 -10. 122 1.00 41. 19 H c

ATOM 6756 O GLN H 6 -1.579 -3. 836 -9. ,831 1.00 35. 70 H 0

ATOM 6758 N SER H 7 -3.410 -4. 478 -10. ,912 1.00 44. 44 H N human fD_Fab

ATOM 6759 CA SER H 7 -2.780 -5 612 -11 572 1.00 41 36 H C

ATOM 6761 CB SER H 7 -3.854 -6 534 -12 172 1.00 40 72 H C

ATOM 6764 OG SER H 7 -4.864 -5 787 -12 854 1.00 38 23 H 0

ATOM 6766 C SER H 7 -1.774 -5 144 -12 633 1.00 41 77 H C

ATOM 6767 O SER H 7 -1.750 -3 963 -13 005 1.00 42 33 H 0

ATOM 6769 N GLY H 8 -0.955 -6 084 -13 106 1.00 38 12 H N

ATOM 6770 CA GLY H 8 0.159 -5 793 -13 984 1.00 39 46 H C

ATOM 6773 C GLY H 8 -0.242 -5 567 -15 424 1.00 39 60 H C

ATOM 6774 O GLY H 8 -1.418 -5 666 -15 757 1.00 40 34 H 0

ATOM 6776 N PRO H 9 0.739 -5 256 -16 282 1.00 39 99 H N

ATOM 6777 CA PRO H 9 0.491 -4 955 -17 678 1.00 41 96 H C

ATOM 6779 CB PRO H 9 1.883 -4 571 -18 216 1.00 42 07 H C

ATOM 6782 CG PRO H 9 2.860 -5 196 -17 297 1.00 42 68 H c

ATOM 6785 CD PRO H 9 2.177 -5 184 -15 946 1.00 47 57 H c

ATOM 6788 C PRO H 9 -0.036 -6 167 -18 402 1.00 44 52 H c

ATOM 6789 O PRO H 9 0.319 -7 284 -18 042 1.00 45 20 H 0

ATOM 6790 N GLU H 10 -0.877 -5 944 -19 412 1.00 46 33 H N

ATOM 6791 CA GLU H 10 -1.410 -7 029 -20 199 1.00 47 53 H C

ATOM 6793 CB GLU H 10 -2.784 -7 379 -19 698 1.00 53 37 H c

ATOM 6796 CG GLU H 10 -2.710 -8 092 -18 383 1.00 54 90 H c

ATOM 6799 CD GLU H 10 -4.055 -8 433 -17 889 1.00 57 03 H c

ATOM 6800 OE1 GLU H 10 -4.560 -7 731 -16 989 1.00 59 14 H 0

ATOM 6801 OE2 GLU H 10 -4.623 -9 391 -18 440 1.00 68 47 H 0

ATOM 6802 C GLU H 10 -1.431 -6 749 -21 686 1.00 46. 71 H c

ATOM 6803 0 GLU H 10 -1.543 -5 606 -22 128 1.00 47 81 H 0

ATOM 6805 N LEU H 11 -1.276 -7 824 -22 448 1.00 48 57 H N

ATOM 6806 CA LEU H 11 -1.296 -7 786 -23 898 1.00 47 81 H c

ATOM 6808 CB LEU H 11 0.007 -8 397 -24 458 1.00 50 65 H c

ATOM 6811 CG LEU H 11 0.072 -8 710 -25 955 1.00 46 87 H c

ATOM 6813 CDl LEU H 11 0.007 -7 438 -26 762 1.00 41 30 H c

ATOM 6817 CD2 LEU H 11 1.315 -9 517 -26 280 1.00 47 16 H c

ATOM 6821 C LEU H 11 -2.498 -8 612 -24 300 1.00 46 37 H c

ATOM 6822 0 LEU H 11 -2.632 -9 756 -23 869 1.00 41 42 H 0

ATOM 6824 N LYS H 12 -3.380 -8 000 -25 087 1.00 46 53 H N

ATOM 6825 CA LYS H 12 -4.588 -8 634 -25 566 1.00 45 75 H c

ATOM 6827 CB LYS H 12 -5.803 -8 007 -24 875 1.00 46 13 H c

ATOM 6830 CG LYS H 12 -5.865 -8 292 -23 376 1.00 42 46 H c

ATOM 6833 CD LYS H 12 -6.254 -9 732 -23 094 1.00 43 81 H c

ATOM 6836 CE LYS H 12 -6.012 - -10 084 -21 650 1.00 44 50 H c

ATOM 6839 NZ LYS H 12 -6.470 - ^• 11 454 -21 313 1.00 42 52 H N

ATOM 6843 C LYS H 12 -4.666 -8 440 -27 062 1.00 44 24 H c

ATOM 6844 0 LYS H 12 -4.068 -7 504 -27 605 1.00 41 65 H 0

ATOM 6846 N LYS H 13 -5.370 -9 347 -27 729 1.00 46 12 H N

ATOM 6847 CA LYS H 13 -5.550 -9 251 -29 167 1.00 50 31 H c

ATOM 6849 CB LYS H 13 -5.668 - -10 646 -29 789 1.00 56 21 H c

ATOM 6852 CG LYS H 13 -4.537 - -11 594 -29 326 1.00 57 01 H c

ATOM 6855 CD LYS H 13 -3.869 - -12 359 -30 468 1.00 55 53 H c

ATOM 6858 CE LYS H 13 -2.612 - -13 118 -29 978 1.00 55 81 H c

ATOM 6861 NZ LYS H 13 -1.466 - -12 995 -30 936 1.00 50 29 H N

ATOM 6865 C LYS H 13 -6.753 -8 379 -29 421 1.00 45 92 H c

ATOM 6866 0 LYS H 13 -7.574 -8 185 -28 524 1.00 44 27 H 0

ATOM 6868 N PRO H 14 -6.839 -7 788 -30 613 1.00 47 12 H N

ATOM 6869 CA PRO H 14 -8.039 -7 030 -30 912 1.00 49 95 H c

ATOM 6871 CB PRO H 14 -7.786 -6 537 -32 339 1.00 50 25 H c

ATOM 6874 CG PRO H 14 -6.311 -6 500 -32 455 1.00 48 04 H c

ATOM 6877 CD PRO H 14 -5.863 -7 704 -31 710 1.00 50 66 H c

ATOM 6880 C PRO H 14 -9.258 -7 929 -30 831 1.00 51 78 H c

ATOM 6881 0 PRO H 14 -9.149 -9 129 -31 139 1.00 52 51 H 0

ATOM 6882 N GLY H 15 -10.386 -7 366 -30 379 1.00 51 68 H N

ATOM 6883 CA GLY H 15 -11.642 -8 122 -30 239 1.00 49 53 H c

ATOM 6886 C GLY H 15 -11.797 -8 818 -28 901 1.00 46 32 H c

ATOM 6887 0 GLY H 15 -12.902 -9 107 -28 487 1.00 51 33 H 0

ATOM 6889 N ALA H 16 -10.685 -9 077 -28 221 1.00 43 87 H N

ATOM 6890 CA ALA H 16 -10.714 -9 655 -26 887 1.00 44 61 H c

ATOM 6892 CB ALA H 16 -9.329 - -10 249 -26 508 1.00 40 53 H c

ATOM 6896 C ALA H 16 -11.180 -8 645 -25 810 1.00 43 92 H c

ATOM 6897 0 ALA H 16 -11.552 -7 488 -26 081 1.00 45 90 H 0

ATOM 6899 N SER H 17 -11.183 -9 122 -24 582 1.00 42 33 H N human fD_Fab

ATOM 6900 CA SER H 17 -11.592 -8 329 -23 456 1.00 47 23 H C

ATOM 6902 CB SER H 17 -12. 929 -8 848 -22 918 1.00 53 98 H c

ATOM 6905 OG SER H 17 -12 745 - -10 020 -22 146 1.00 56 45 H 0

ATOM 6907 C SER H 17 -10 518 -8 408 -22 372 1.00 47 23 H c

ATOM 6908 O SER H 17 -9. 720 -9 361 -22 331 1.00 43 65 H 0

ATOM 6910 N VAL H 18 -10. 500 -7 411 -21 497 1.00 45 22 H N

ATOM 6911 CA VAL H 18 -9. 517 -7 387 -20 411 1.00 45 51 H c

ATOM 6913 CB VAL H 18 -8. 282 -6 498 -20 768 1.00 46 57 H c

ATOM 6915 CGI VAL H 18 -8. 649 -5 047 -20 735 1.00 45 60 H c

ATOM 6919 CG2 VAL H 18 -7. 122 -6 783 -19 816 1.00 45 99 H c

ATOM 6923 C VAL H 18 -10. 163 -6 918 -19 106 1.00 46 25 H c

ATOM 6924 O VAL H 18 -11. 101 -6 131 -19 109 1.00 39 23 H 0

ATOM 6926 N LYS H 19 -9. 652 -7 424 -17 988 1.00 50 25 H N

ATOM 6927 CA LYS H 19 -10. 161 -7 053 -16 684 1.00 47 70 H c

ATOM 6929 CB LYS H 19 -10. 854 -8 244 -16 026 1.00 51 54 H C

ATOM 6932 CG LYS H 19 -11. 356 -7 962 -14 609 1.00 57 22 H C

ATOM 6935 CD LYS H 19 -12. 866 -7 841 -14 520 1.00 61 40 H c

ATOM 6938 CE LYS H 19 -13. 479 -9 111 -13 974 1.00 62 59 H c

ATOM 6941 NZ LYS H 19 -14. 945 -8 960 -13 816 1.00 63 97 H N

ATOM 6945 C LYS H 19 -9. 010 -6 574 -15 802 1.00 44 19 H c

ATOM 6946 O LYS H 19 -8. 164 -7 361 -15 421 1.00 44 02 H 0

ATOM 6948 N VAL H 20 -9. 014 -5 290 -15 459 1.00 43 25 H N

ATOM 6949 CA VAL H 20 -8. 010 -4 701 -14 580 1.00 42 18 H c

ATOM 6951 CB VAL H 20 -7. 571 -3 308 -15 082 1.00 38 88 H c

ATOM 6953 CGI VAL H 20 -6. 553 -2 688 -14 164 1.00 38 24 H c

ATOM 6957 CG2 VAL H 20 -7. 009 -3 439 -16 482 1.00 35 76 H c

ATOM 6961 C VAL H 20 -8. 565 -4 605 -13 167 1.00 41 65 H c

ATOM 6962 0 VAL H 20 -9. 737 -4 277 -12 966 1.00 42 26 H 0

ATOM 6964 N SER H 21 -7. 724 -4 909 -12 184 1.00 43 70 H N

ATOM 6965 CA SER H 21 -8. 123 -4 855 -10 788 1.00 41 09 H c

ATOM 6967 CB SER H 21 -7. 819 -6 172 -10 052 1.00 48 51 H c

ATOM 6970 OG SER H 21 -6. 435 -6 461 -9 991 1.00 52 42 H 0

ATOM 6972 C SER H 21 -7. 475 -3 681 -10 076 1.00 42 88 H c

ATOM 6973 0 SER H 21 -6. 356 -3 258 -10 417 1.00 41 68 H 0

ATOM 6975 N CYS H 22 -8. 215 -3 147 -9 102 1.00 42 75 H N

ATOM 6976 CA CYS H 22 -7. 755 -2 100 -8 217 1.00 40 50 H c

ATOM 6978 CB CYS H 22 -8. 450 -0 763 -8 548 1.00 41 81 H c

ATOM 6981 SG CYS H 22 -7. 980 0 592 -7 398 1.00 42 41 H s

ATOM 6983 C CYS H 22 -8. 043 -2 521 -6 761 1.00 38 28 H c

ATOM 6984 0 CYS H 22 -9. 115 -2 229 -6 220 1.00 37 51 H 0

ATOM 6986 N LYS H 23 -7. 069 -3 177 -6 132 1.00 40 57 H N

ATOM 6987 CA LYS H 23 -7. 179 -3 620 -4 737 1.00 43 95 H c

ATOM 6989 CB LYS H 23 -6. 211 -4 775 -4 438 1.00 48 68 H c

ATOM 6992 CG LYS H 23 -6. 407 -6 037 -5 293 1.00 58 62 H c

ATOM 6995 CD LYS H 23 -5. 069 -6 752 -5 685 1.00 59 16 H c

ATOM 6998 CE LYS H 23 -4. 404 -7 554 -4 541 1.00 62 49 H c

ATOM 7001 NZ LYS H 23 -2. 913 -7 774 -4 753 1.00 57 21 H N

ATOM 7005 C LYS H 23 -6. 856 -2 463 -3 776 1.00 41 66 H c

ATOM 7006 0 LYS H 23 -5. 757 -1 921 -3 793 1.00 41 41 H 0

ATOM 7008 N ALA H 24 -7. 812 -2 120 -2 922 1.00 39 41 H N

ATOM 7009 CA ALA H 24 -7. 690 -1 004 -2 000 1.00 37 89 H c

ATOM 7011 CB ALA H 24 -9. 002 -0 198 -2 Oil 1.00 29 31 H c

ATOM 7015 C ALA H 24 -7. 404 -1 516 -0 592 1.00 37 96 H c

ATOM 7016 0 ALA H 24 -7. 988 -2 511 -0 147 1.00 35 64 H 0

ATOM 7018 N SER H 25 -6. 524 -0 826 0 123 1.00 41 16 H N

ATOM 7019 CA SER H 25 -6. 249 -1 171 1 532 1.00 40 67 H c

ATOM 7021 CB SER H 25 -4. 960 -2 028 1 679 1.00 38 85 H c

ATOM 7024 OG SER H 25 -4. 445 -2 478 0 422 1.00 45 75 H 0

ATOM 7026 C SER H 25 -6. 133 0 115 2 363 1.00 38 77 H c

ATOM 7027 0 SER H 25 -5. 933 1 184 1 829 1.00 36 88 H 0

ATOM 7029 N GLY H 26 -6. 230 -0 018 3 674 1.00 39 12 H N

ATOM 7030 CA GLY H 26 -5. 881 1 061 4 588 1.00 39 22 H c

ATOM 7033 C GLY H 26 -7. 044 1 945 5 013 1.00 40 31 H c

ATOM 7034 0 GLY H 26 -6. 873 2 920 5 770 1.00 43 74 H 0

ATOM 7036 N TYR H 27 -8. 227 1 611 4 519 1.00 36 28 H N

ATOM 7037 CA TYR H 27 -9. 412 2 398 4 767 1.00 35 38 H c

ATOM 7039 CB TYR H 27 -9. 430 3 663 3 895 1.00 35 94 H c

ATOM 7042 CG TYR H 27 -9. 750 3 425 2 427 1.00 35 71 H c human fD_Fab

ATOM 7043 CDl TYR H 27 -11, .055 3. 634 1. 924 1.00 37. ,41 H C

ATOM 7045 CEl TYR H 27 -11. .352 3. 421 0. 587 1.00 34. 95 H C

ATOM 7047 CZ TYR H 27 -10, .334 3. 005 -0. 276 1.00 35. ,55 H C

ATOM 7048 OH TYR H 27 -10, .588 2. 801 -1. 608 1.00 33. ,27 H 0

ATOM 7050 CE2 TYR H 27 -9, .043 2. 801 0. 201 1.00 36. 94 H C

ATOM 7052 CD2 TYR H 27 -8, .760 3. 004 1. 543 1.00 34. 54 H C

ATOM 7054 C TYR H 27 -10, .669 1. 571 4. 499 1.00 34. ,75 H C

ATOM 7055 O TYR H 27 -10, .593 0. 443 4. 033 1.00 31. ,57 H 0

ATOM 7057 N THR H 28 -11, .830 2. 143 4. 794 1.00 38. ,68 H N

ATOM 7058 CA THR H 28 -13, .099 1. 443 4. 547 1.00 37. ,61 H C

ATOM 7060 CB THR H 28 -14, .251 1. 933 5. 486 1.00 40. ,36 H C

ATOM 7062 OG1 THR H 28 -13, .831 1. 847 6. 849 1.00 42. ,52 H 0

ATOM 7064 CG2 THR H 28 -15, .532 1. 066 5. 301 1.00 42. ,93 H C

ATOM 7068 C THR H 28 -13. .557 1. 602 3. 092 1.00 37. 95 H c

ATOM 7069 O THR H 28 -14. .098 2. 634 2. 707 1.00 37. 82 H 0

ATOM 7071 N PHE H 29 -13, .371 0. 546 2. 310 1.00 39. ,48 H N

ATOM 7072 CA PHE H 29 -13, .672 0. 529 0. 880 1.00 38. ,21 H c

ATOM 7074 CB PHE H 29 -13, .834 -0. 916 0. 449 1.00 37. ,30 H c

ATOM 7077 CG PHE H 29 -13, .892 -1. 125 -1. 039 1.00 40. ,52 H c

ATOM 7078 CDl PHE H 29 -12, .870 -0. 680 -1. 864 1.00 40. ,12 H c

ATOM 7080 CEl PHE H 29 -12, .923 -0. 894 -3. 248 1.00 37. ,44 H c

ATOM 7082 CZ PHE H 29 -13. .995 -1. 588 -3. 806 1.00 37. 58 H c

ATOM 7084 CE2 PHE H 29 -14. .997 -2. 065 -3. 002 1.00 35. ,77 H c

ATOM 7086 CD2 PHE H 29 -14. ,944 -1. 842 -1. 611 1.00 40. 68 H c

ATOM 7088 C PHE H 29 -14, ,948 1. 302 0. 521 1.00 38. ,70 H c

ATOM 7089 O PHE H 29 -14, .979 2. 115 -0. 428 1.00 36. 24 H 0

ATOM 7091 N THR H 30 -15, , 999 1. 045 1. 288 1.00 39. ,29 H N

ATOM 7092 CA THR H 30 -17, .344 1. 533 0. 949 1.00 36. ,64 H c

ATOM 7094 CB THR H 30 -18, .502 0. 663 1. 541 1.00 37. 48 H c

ATOM 7096 OGl THR H 30 -18. .355 0. 537 2. 961 1.00 34. 24 H 0

ATOM 7098 CG2 THR H 30 -18. .565 -0. 711 0. 881 1.00 31. 39 H c

ATOM 7102 C THR H 30 -17. ,612 2. 965 1. 380 1.00 35. 00 H c

ATOM 7103 O THR H 30 -18. ,674 3. 504 1. 083 1.00 37. ,71 H 0

ATOM 7105 N ASN H 31 -16, .675 3. 591 2. 078 1.00 36. ,04 H N

ATOM 7106 CA ASN H 31 -16, .818 5. 004 2. 397 1.00 37. ,44 H c

ATOM 7108 CB ASN H 31 -15, .923 5. 374 3. 588 1.00 44. ,04 H c

ATOM 7111 CG ASN H 31 -16, .546 4. 994 4. 922 1.00 43. ,80 H c

ATOM 7112 ODl ASN H 31 -17, .609 4. 348 4. 970 1.00 37. ,35 H 0

ATOM 7113 ND2 ASN H 31 -15. .887 5. 398 6. 019 1.00 43. ,42 H N

ATOM 7116 C ASN H 31 -16. ,531 5. 926 1. 208 1.00 33. 99 H c

ATOM 7117 0 ASN H 31 -16. .973 7. 077 1. 177 1.00 32. ,67 H 0

ATOM 7119 N TYR H 32 -15. ,780 5. 430 0. 234 1.00 35. 95 H N

ATOM 7120 CA TYR H 32 -15, .290 6. 251 -0. 857 1.00 35. ,74 H c

ATOM 7122 CB TYR H 32 -13, .815 6. 484 -0. 666 1.00 41. ,31 H c

ATOM 7125 CG TYR H 32 -13, .440 7. 234 0. ,579 1.00 41. ,68 H c

ATOM 7126 CDl TYR H 32 -13, .091 8. 567 0. 510 1.00 40. ,27 H c

ATOM 7128 CEl TYR H 32 -12, .708 9. 262 1. 624 1.00 40. ,72 H c

ATOM 7130 CZ TYR H 32 -12, .671 8. 648 2. 847 1.00 43. ,51 H c

ATOM 7131 OH TYR H 32 -12, .271 9. 403 3. 940 1.00 43. ,46 H 0

ATOM 7133 CE2 TYR H 32 -13, ,032 7. 312 2. 962 1.00 43. ,36 H c

ATOM 7135 CD2 TYR H 32 -13. ,404 6. 607 1. 817 1.00 41. ,58 H c

ATOM 7137 C TYR H 32 -15, .479 5. 508 -2. ,146 1.00 34, ,61 H c

ATOM 7138 O TYR H 32 -15, .144 4. 345 -2. ,224 1.00 35. ,22 H 0

ATOM 7140 N GLY H 33 -15, .980 6. 202 -3. ,168 1.00 37. ,25 H N

ATOM 7141 CA GLY H 33 -16, .134 5. 631 -4. ,502 1.00 34. ,00 H c

ATOM 7144 C GLY H 33 -14, ,786 5. 504 -5. ,185 1.00 33. ,97 H c

ATOM 7145 O GLY H 33 -13, .754 5. 887 -4. ,619 1.00 35. ,49 H 0

ATOM 7147 N MET H 34 -14, ,799 4. 984 -6. ,410 1.00 31. ,65 H N

ATOM 7148 CA MET H 34 -13, .582 4. 786 -7. ,189 1.00 32. ,60 H c

ATOM 7150 CB MET H 34 -13, .293 3. 279 -7. ,315 1.00 34. ,92 H c

ATOM 7153 CG MET H 34 -11, .840 2. 878 -7. 630 1.00 36. .96 H c

ATOM 7156 SD MET H 34 -10, .641 3. 345 -6. ,341 1.00 42, , 66 H s

ATOM 7157 CE MET H 34 -10, .978 2. 083 -5. ,110 1.00 38. ,61 H c

ATOM 7161 C MET H 34 -13, .760 5. 415 -8. ,565 1.00 31. , 99 H c

ATOM 7162 O MET H 34 -14, .744 5. 126 -9. 254 1.00 33. ,25 H 0

ATOM 7164 N ASN H 35 -12, .827 6. 291 -8. 955 1.00 29. ,67 H N

ATOM 7165 CA ASN H 35 -12, .793 6. 829 -10. 316 1.00 30. ,93 H c

ATOM 7167 CB ASN H 35 -12, .310 8. 270 -10. 329 1.00 38. ,41 H c human fD_Fab

ATOM 7170 CG ASN H 35 -13. 121 9. 159 -9. ,433 1.00 36. ,55 H C

ATOM 7171 ODl ASN H 35 -14. 293 8. 883 -9. 170 1.00 35. 28 H 0

ATOM 7172 ND2 ASN H 35 -12. 505 10. 241 -8. 956 1.00 34. 90 H N

ATOM 7175 C ASN H 35 -11. 868 5. 999 -11.188 1.00 29. 55 H C

ATOM 7176 O ASN H 35 -10. 906 5. 403 -10. 694 1.00 29. 61 H 0

ATOM 7178 N TRP H 36 -12. 186 5. 946 -12. 478 1.00 33. 67 H N

ATOM 7179 CA TRP H 36 -11. 316 5. 339 -13. 479 1.00 32. 57 H C

ATOM 7181 CB TRP H 36 -12. 054 4. 189 -14. 174 1.00 34. 47 H C

ATOM 7184 CG TRP H 36 -12. 151 2. 998 -13. 278 1.00 36. 68 H c

ATOM 7185 CDl TRP H 36 -13. 222 2. 629 -12. 476 1.00 34. 33 H c

ATOM 7187 NEl TRP H 36 -12. 907 1. 493 -11. 779 1.00 33. 27 H N

ATOM 7189 CE2 TRP H 36 -11.626 1. 104 -12. 100 1.00 35. 81 H c

ATOM 7190 CD2 TRP H 36 -11. 120 2. 033 -13. 037 1.00 37. 28 H c

ATOM 7191 CE3 TRP H 36 -9. 820 1. 854 -13. 531 1.00 36. 98 H c

ATOM 7193 CZ3 TRP H 36 -9. 071 0. 759 -13. 070 1.00 35. 74 H c

ATOM 7195 CH2 TRP H 36 -9. 615 -0. 149 -12. 152 1.00 34. 72 H c

ATOM 7197 CZ2 TRP H 36 -10. 879 0. 000 -11. 665 1.00 34. 45 H c

ATOM 7199 C TRP H 36 -10. 838 6. 401 -14. 472 1.00 31. 55 H c

ATOM 7200 O TRP H 36 -11. 616 7. 241 -14. 929 1.00 33. 50 H 0

ATOM 7202 N VAL H 37 -9. 545 6. 376 -14. 770 1.00 35. 31 H N

ATOM 7203 CA VAL H 37 -8. 907 7. 379 -15. 621 1.00 32. 74 H c

ATOM 7205 CB VAL H 37 -8. 078 8. 327 -14. 728 1.00 35. 31 H c

ATOM 7207 CGI VAL H 37 -7. 252 9. 344 -15. 548 1.00 31. 80 H c

ATOM 7211 CG2 VAL H 37 -9. 002 9. 029 -13. 700 1.00 28. 38 H c

ATOM 7215 C VAL H 37 -8. 028 6. 653 -16. 652 1.00 34. 51 H c

ATOM 7216 O VAL H 37 -7. 355 5. 664 -16. 328 1.00 31. 66 H 0

ATOM 7218 N ARG H 38 -8. 072 7. 129 -17. 891 1.00 35. 53 H N

ATOM 7219 CA ARG H 38 -7. 304 6. 561 -18. 998 1.00 36. 02 H c

ATOM 7221 CB ARG H 38 -8. 285 6. 245 -20. 125 1.00 38. 86 H c

ATOM 7224 CG ARG H 38 -7. 703 5. 713 -21. 398 1.00 38. 77 H c

ATOM 7227 CD ARG H 38 -8. 786 5. 655 -22. 452 1.00 42. 62 H c

ATOM 7230 NE ARG H 38 -8. 282 5. 229 -23. 748 1.00 44. 69 H N

ATOM 7232 CZ ARG H 38 -8. 094 6. 013 -24. 818 1.00 56. 14 H c

ATOM 7233 NHl ARG H 38 -8. 361 7. 312 -24. 800 1.00 57. 13 H N

ATOM 7236 NH2 ARG H 38 -7. 634 5. 483 -25. 941 1.00 56. 02 H N

ATOM 7239 C ARG H 38 -6. 248 7. 552 -19. 509 1.00 34. 09 H C

ATOM 7240 0 ARG H 38 -6. 507 8. 747 -19. 595 1.00 30. 74 H 0

ATOM 7242 N GLN H 39 -5. 064 7. 057 -19. 862 1.00 32. 78 H N

ATOM 7243 CA GLN H 39 -4. 079 7. 870 -20. 594 1.00 32. 90 H C

ATOM 7245 CB GLN H 39 -2. 996 8. 369 -19. 663 1.00 30. 72 H C

ATOM 7248 CG GLN H 39 -2. 163 9. 503 -20. 270 1.00 34. 90 H C

ATOM 7251 CD GLN H 39 -1. 277 10. 138 -19. 245 1.00 36. 13 H c

ATOM 7252 OEl GLN H 39 -0. 820 9. 471 -18. 315 1.00 42. 34 H 0

ATOM 7253 NE2 GLN H 39 -1. 023 11. 423 -19. 396 1.00 39. 51 H N

ATOM 7256 C GLN H 39 -3. 435 7. 106 -21. 746 1.00 36. 84 H c

ATOM 7257 0 GLN H 39 -2. 567 6. 241 -21. 542 1.00 39. 35 H 0

ATOM 7259 N ALA H 40 -3. 882 7. 403 -22. 960 1.00 38. 89 H N

ATOM 7260 CA ALA H 40 -3. 262 6. 842 -24. 145 1.00 39. 82 H c

ATOM 7262 CB ALA H 40 -4. 056 7. 213 -25. 394 1.00 35. 21 H c

ATOM 7266 C ALA H 40 -1. 825 7. 387 -24. 228 1.00 43. 70 H c

ATOM 7267 0 ALA H 40 -1. 533 8. 460 -23. 664 1.00 43. 29 H 0

ATOM 7269 N PRO H 41 -0. 925 6. 656 -24. 922 1.00 44. 16 H N

ATOM 7270 CA PRO H 41 0. 473 7. 054 -24. 945 1.00 48. 23 H c

ATOM 7272 CB PRO H 41 1. 143 5. 956 -25. ,785 1.00 51. 01 H c

ATOM 7275 CG PRO H 41 0. 213 4. 784 -25. 668 1.00 48. 33 H c

ATOM 7278 CD PRO H 41 -1. 136 5. 419 -25. ,693 1.00 47. 24 H c

ATOM 7281 C PRO H 41 0. 718 8. 454 -25. 521 1.00 47. 09 H c

ATOM 7282 0 PRO H 41 0. 339 8. 746 -26.653 1.00 47. 59 H 0

ATOM 7283 N GLY H 42 1. 313 9. 313 -24. 699 1.00 48. 32 H N

ATOM 7284 CA GLY H 42 1. 620 10. 688 -25. ,081 1.00 49. 56 H c

ATOM 7287 C GLY H 42 0. 422 11. 629 -25. 108 1.00 51.19 H c

ATOM 7288 0 GLY H 42 0. 553 12. 770 -25. ,570 1.00 54. 61 H 0

ATOM 7290 N GLN H 43 -0. 739 11. 168 -24. 637 1.00 48. 17 H N

ATOM 7291 CA GLN H 43 -1. 971 11. 970 -24. 663 1.00 43. 52 H c

ATOM 7293 CB GLN H 43 -3. 107 11. 147 -25. 249 1.00 47. 91 H c

ATOM 7296 CG GLN H 43 -2. 807 10. 646 -26. ,641 1.00 54. 23 H c

ATOM 7299 CD GLN H 43 -2. 197 11. 728 -27. ,493 1.00 61. 41 H c

ATOM 7300 OEl GLN H 43 -0. 988 11. 758 -27. ,695 1.00 65. 50 H 0 human fD_Fab

ATOM 7301 NE2 GLN H 43 -3. 025 12. ,658 -27. 957 1. 00 65. 88 H N

ATOM 7304 C GLN H 43 -2 . 324 12. 454 -23. ,269 1. 00 39. 74 H C

ATOM 7305 O GLN H 43 -1. 603 12. ,178 -22 . 322 1. 00 39. 98 H 0

ATOM 7307 N GLY H 44 -3. 415 13. ,200 -23. 142 1.00 35. 42 H N

ATOM 7308 CA GLY H 44 -3. 819 13. ,714 -21. ,854 1.00 34. ,85 H C

ATOM 7311 C GLY H 44 -4. 646 12. ,716 -21. ,063 1.00 34. ,31 H C

ATOM 7312 O GLY H 44 -4. 988 11. ,640 -21. ,557 1. 00 37. 19 H 0

ATOM 7314 N LEU H 45 -4. 964 13. ,100 -19. 826 1. 00 34. 18 H N

ATOM 7315 CA LEU H 45 -5. 808 12. ,312 -18. 921 1. 00 32. ,85 H c

ATOM 7317 CB LEU H 45 -5. 637 12. ,817 -17. ,487 1. 00 34. ,12 H c

ATOM 7320 CG LEU H 45 -4. 291 12. ,714 -16. 771 1. 00 33. 64 H c

ATOM 7322 CDl LEU H 45 -4. 379 13. ,432 -15. 423 1. 00 34. 35 H c

ATOM 7326 CD2 LEU H 45 -3. 853 11. 271 -16. 562 1. 00 36. 29 H c

ATOM 7330 C LEU H 45 -7. 292 12. 380 -19. 313 1.00 31. 68 H c

ATOM 7331 O LEU H 45 -7. 785 13. ,421 -19. 706 1.00 32. ,19 H 0

ATOM 7333 N GLU H 46 -7. 989 11. ,253 -19. ,177 1.00 35. ,41 H N

ATOM 7334 CA GLU H 46 -9. 391 11. ,116 -19. 540 1.00 35. ,81 H c

ATOM 7336 CB GLU H 46 -9. 554 10. ,252 -20. ,769 1.00 37. 73 H c

ATOM 7339 CG GLU H 46 -9. 007 10. 885 -22 . ,006 1. 00 43. ,61 H c

ATOM 7342 CD GLU H 46 -9. 023 9. 930 -23. ,159 1. 00 45. ,03 H c

ATOM 7343 OEl GLU H 46 -7. 937 9. ,384 -23. ,474 1. 00 50. ,98 H 0

ATOM 7344 OE2 GLU H 46 -10. 114 9. ,712 -23. 727 1. 00 46.27 H 0

ATOM 7345 C GLU H 46 -10. 149 10. 442 -18. 435 1. 00 35. 60 H c

ATOM 7346 0 GLU H 46 -9. 874 9. ,274 -18. ,126 1.00 31. 88 H 0

ATOM 7348 N TRP H 47 -11.102 11. ,193 -17. ,871 1. 00 32. ,10 H N

ATOM 7349 CA TRP H 47 -11. 984 10. ,729 -16. ,860 1. 00 34. ,63 H c

ATOM 7351 CB TRP H 47 -12. 703 11. 940 -16. ,219 1. 00 37. ,13 H c

ATOM 7354 CG TRP H 47 -13. 132 11. ,655 -14. 831 1.00 36. ,26 H c

ATOM 7355 CDl TRP H 47 -12. 384 11. 776 -13. 708 1.00 35. 96 H c

ATOM 7357 NEl TRP H 47 -13. 101 11. 383 -12. 621 1.00 35. ,97 H N

ATOM 7359 CE2 TRP H 47 -14. 339 10. 968 -13. 039 1. 00 34. , 00 H c

ATOM 7360 CD2 TRP H 47 -14. 385 11. 120 -14. ,430 1. 00 33. ,29 H c

ATOM 7361 CE3 TRP H 47 -15. 562 10. 787 -15. 115 1. 00 36. ,82 H c

ATOM 7363 CZ3 TRP H 47 -16. 628 10. 326 -14. ,407 1. 00 36. ,76 H c

ATOM 7365 CH2 TRP H 47 -16. 552 10. ,180 -13. ,005 1. 00 38. ,30 H c

ATOM 7367 CZ2 TRP H 47 -15. 412 10. ,493 -12. 313 1. 00 35. ,51 H c

ATOM 7369 C TRP H 47 -12. 998 9. ,743 -17. ,475 1. 00 36. ,24 H c

ATOM 7370 0 TRP H 47 -13. 868 10. ,118 -18. ,265 1. 00 35. ,47 H 0

ATOM 7372 N MET H 48 -12. 883 8 . ,477 -17. ,116 1. 00 33. ,60 H N

ATOM 7373 CA MET H 48 -13. 699 7. ,437 -17. ,743 1. 00 36. ,97 H c

ATOM 7375 CB MET H 48 -12. 994 6. 080 -17. ,639 1. 00 36. ,09 H c

ATOM 7378 CG MET H 48 -11.743 6. ,010 -18. ,455 1. 00 37. ,06 H c

ATOM 7381 SD MET H 48 -10. 894 4. ,444 -18. ,220 1.00 38. ,14 H s

ATOM 7382 CE MET H 48 -12. 035 3. ,348 -19. ,051 1.00 32. ,38 H c

ATOM 7386 C MET H 48 -15. 064 7. ,306 -17. ,100 1.00 37. ,72 H c

ATOM 7387 0 MET H 48 -16. 097 7. ,131 -17. ,785 1.00 39. ,03 H 0

ATOM 7389 N GLY H 49 -15. 052 7. ,333 -15. ,777 1.00 37. ,51 H N

ATOM 7390 CA GLY H 49 -16. 256 7. ,129 -15. ,007 1.00 39. ,63 H c

ATOM 7393 C GLY H 49 -15. 994 6. ,916 -13. ,528 1. 00 38. ,13 H c

ATOM 7394 0 GLY H 49 -14. 855 6. ,938 -13. ,085 1.00 37. ,98 H 0

ATOM 7396 N TRP H 50 -17. 085 6. ,742 -12. ,784 1. 00 38. ,96 H N

ATOM 7397 CA TRP H 50 -17. 083 6. ,476 -11.354 1. 00 39. ,32 H c

ATOM 7399 CB TRP H 50 -17. 660 7. ,734 -10. ,655 1.00 40. ,19 H c

ATOM 7402 CG TRP H 50 -18. 758 7. ,566 -9. ,643 1. 00 36.03 H c

ATOM 7403 CDl TRP H 50 -20. 037 7. ,212 -9. ,882 1. 00 36. ,96 H c

ATOM 7405 NEl TRP H 50 -20. 752 7. ,178 -8 . ,701 1. 00 36. ,57 H N

ATOM 7407 CE2 TRP H 50 -19. 929 7. ,539 -7. ,672 1. 00 34. ,53 H c

ATOM 7408 CD2 TRP H 50 -18. 664 7. ,804 -8. ,224 1. 00 35. ,85 H c

ATOM 7409 CE3 TRP H 50 -17. 621 8 . ,178 -7. ,368 1. 00 36. ,68 H c

ATOM 7411 CZ3 TRP H 50 -17. 877 8. ,304 -6. ,023 1. 00 36. ,79 H c

ATOM 7413 CH2 TRP H 50 -19. 147 8. ,033 -5. ,495 1.00 37. ,80 H c

ATOM 7415 CZ2 TRP H 50 -20. 189 7. ,658 -6. ,305 1. 00 39. ,26 H c

ATOM 7417 C TRP H 50 -17. 912 5. .214 -11.050 1.00 39. .23 H c

ATOM 7418 0 TRP H 50 -18. 866 4. ,912 -11. ,765 1.00 35, .89 H 0

ATOM 7420 N ILE H 51 -17. 498 4. ,458 -10. ,027 1. 00 37, .83 H N

ATOM 7421 CA ILE H 51 -18. 346 3. ,431 -9, ,438 1. 00 38. 80 H c

ATOM 7423 CB ILE H 51 -17. 781 1. 991 -9. ,645 1.00 40. .46 H c

ATOM 7425 CGl ILE H 51 -18. 849 0. 935 -9. ,250 1. 00 40.79 H c human fD_Fab

ATOM 7428 CDl ILE H 51 -18. 888 -0. 324 -10. 148 1.00 39. 97 H C

ATOM 7432 CG2 ILE H 51 -16. 478 1. 826 -8. 878 1.00 34. 34 H C

ATOM 7436 C ILE H 51 -18. 558 3. 715 -7. 946 1.00 38. 29 H c

ATOM 7437 O ILE H 51 -17. 622 3. 918 -7. 198 1.00 36. 10 H 0

ATOM 7439 N ASN H 52 -19. 815 3. 750 -7. 529 1.00 38. ,79 H N

ATOM 7440 CA ASN H 52 -20. 145 3. 912 -6. 122 1.00 36. 28 H c

ATOM 7442 CB ASN H 52 -21. 585 4. 396 -5. 980 1.00 33. 26 H c

ATOM 7445 CG ASN H 52 -21. 943 4. 749 -4. 565 1.00 35. 45 H c

ATOM 7446 ODl ASN H 52 -21.675 3. 994 -3. 632 1.00 35. 68 H 0

ATOM 7447 ND2 ASN H 52 -22. 579 5. 892 -4. 394 1.00 33. 30 H N

ATOM 7450 C ASN H 52 -19. 929 2. 573 -5. 432 1.00 35. 39 H c

ATOM 7451 O ASN H 52 -20. 619 1. 623 -5. 733 1.00 31. 82 H 0

ATOM 7453 N THR H 53 -18. 952 2. 514 -4. 523 1.00 38. 91 H N

ATOM 7454 CA THR H 53 -18. 562 1. 264 -3. 858 1.00 37. 86 H c

ATOM 7456 CB THR H 53 -17. 205 1. 426 -3. 213 1.00 35. 94 H c

ATOM 7458 OGl THR H 53 -17. 259 2. 561 -2. 347 1.00 37. 41 H 0

ATOM 7460 CG2 THR H 53 -16. 151 1. 637 -4. 270 1.00 38. 55 H c

ATOM 7464 C THR H 53 -19. 512 0. 827 -2. 752 1.00 38. 34 H c

ATOM 7465 O THR H 53 -19. 355 -0. 272 -2. 198 1.00 39. 70 H 0

ATOM 7467 N TYR H 54 -20. 434 1. 715 -2. 377 1.00 38. 18 H N

ATOM 7468 CA TYR H 54 -21. 450 1. 423 -1. 356 1.00 36. 73 H c

ATOM 7470 CB TYR H 54 -21. 900 2. 695 -0. 615 1.00 37. ,16 H c

ATOM 7473 CG TYR H 54 -22. 821 2. 452 0. 575 1.00 36. ,13 H c

ATOM 7474 CDl TYR H 54 -22. 395 2. 720 1. 874 1.00 37. 48 H c

ATOM 7476 CEl TYR H 54 -23. 233 2. 515 2. 979 1.00 36. 84 H c

ATOM 7478 CZ TYR H 54 -24. 515 2. 023 2. 795 1.00 37. 51 H c

ATOM 7479 OH TYR H 54 -25. 336 1. 799 3. 895 1.00 36. 82 H 0

ATOM 7481 CE2 TYR H 54 -24. 969 1. 747 1. 508 1.00 36. 73 H c

ATOM 7483 CD2 TYR H 54 -24. 116 1. 963 0. 406 1.00 38. 87 H c

ATOM 7485 C TYR H 54 -22. 674 0. 820 -2. 046 1.00 40. ,64 H c

ATOM 7486 O TYR H 54 -23. 216 -0. 193 -1. 606 1.00 41. 79 H 0

ATOM 7488 N THR H 55 -23. 106 1. 475 -3. 128 1.00 41. 00 H N

ATOM 7489 CA THR H 55 -24. 347 1. 132 -3. 814 1.00 39. 47 H c

ATOM 7491 CB THR H 55 -25. 219 2. 353 -4. 178 1.00 41. 85 H c

ATOM 7493 OGl THR H 55 -24. 547 3. 137 -5. 179 1.00 47. 24 H 0

ATOM 7495 CG2 THR H 55 -25. 520 3. 196 -2. 951 1.00 38. 40 H c

ATOM 7499 C THR H 55 -24. 128 0. 369 -5. 123 1.00 41. 26 H c

ATOM 7500 O THR H 55 -25. 051 -0. 249 -5. 634 1.00 43. ,37 H 0

ATOM 7502 N GLY H 56 -22. 929 0. 432 -5. 695 1.00 40. 36 H N

ATOM 7503 CA GLY H 56 -22. 648 -0. 288 -6. 935 1.00 38. ,27 H c

ATOM 7506 C GLY H 56 -23. 104 0. 435 -8. 179 1.00 39. 84 H c

ATOM 7507 O GLY H 56 -22. 891 -0. 067 -9. 277 1.00 42. 42 H 0

ATOM 7509 N GLU H 57 -23. 731 1. 605 -8. 020 1.00 40. 68 H N

ATOM 7510 CA GLU H 57 -24. 110 2. 440 -9. 145 1.00 40. 64 H c

ATOM 7512 CB GLU H 57 -24. 850 3. 707 -8. 703 1.00 45. 68 H c

ATOM 7515 CG GLU H 57 -26. 209 3. 510 -8. 059 1.00 49. 60 H c

ATOM 7518 CD GLU H 57 -26. 622 4. 723 -7. 233 1.00 53. ,37 H c

ATOM 7519 OEl GLU H 57 -26. 283 4. 748 -6. 024 1.00 58. ,46 H 0

ATOM 7520 OE2 GLU H 57 -27. 250 5. 653 -7. 791 1.00 54. 24 H 0

ATOM 7521 C GLU H 57 -22. 850 2. 895 -9. 848 1.00 40. ,80 H c

ATOM 7522 O GLU H 57 -21. 774 2. 989 -9. 230 1.00 37. 28 H 0

ATOM 7524 N THR H 58 -23. 022 3. 233 -11. 125 1.00 40. ,14 H N

ATOM 7525 CA THR H 58 -21. 928 3. 623 -12. 004 1.00 39. ,91 H c

ATOM 7527 CB THR H 58 -21. 513 2. 460 -12. 948 1.00 39. ,54 H c

ATOM 7529 OGl THR H 58 -22. 618 2. 082 -13. 797 1.00 37. ,19 H 0

ATOM 7531 CG2 THR H 58 -21. 034 1. 230 -12. 122 1.00 32. ,89 H c

ATOM 7535 C THR H 58 -22. 320 4. 823 -12. 843 1.00 42. ,95 H c

ATOM 7536 O THR H 58 -23. 486 4. 991 -13. 209 1.00 40. ,76 H 0

ATOM 7538 N THR H 59 -21.340 5. 670 -13. 155 1.00 43. ,98 H N

ATOM 7539 CA THR H 59 -21. 551 6. 746 -14. 110 1.00 40. ,17 H c

ATOM 7541 CB THR H 59 -21. 780 8. 100 -13. 446 1.00 43. ,00 H c

ATOM 7543 OGl THR H 59 -22. 850 7. 994 -12. 495 1.00 48. ,02 H 0

ATOM 7545 CG2 THR H 59 -22. 155 9. ,137 -14. ,505 1.00 40, ,84 H c

ATOM 7549 C THR H 59 -20. 362 6. 844 -15. ,047 1.00 42. ,75 H c

ATOM 7550 O THR H 59 -19. 200 6. 909 -14. ,617 1.00 44. ,86 H 0

ATOM 7552 N TYR H 60 -20. 670 6. 883 -16. ,336 1.00 42. ,67 H N

ATOM 7553 CA TYR H 60 -19. 669 6. 815 -17. ,376 1.00 41. ,64 H c

ATOM 7555 CB TYR H 60 -20. 005 5. 669 -18. 335 1.00 40. ,97 H c human fD_Fab

ATOM 7558 CG TYR H 60 -19.934 4. 312 -17. 691 1.00 39.33 H C

ATOM 7559 CDl TYR H 60 -18.714 3 . 625 -17. 607 1.00 41.14 H C

ATOM 7561 CEl TYR H 60 -18.616 2. 365 -16. 993 1. 00 37.37 H c

ATOM 7563 cz TYR H 60 -19.748 1. 768 -16. 474 1.00 39.80 H c

ATOM 7564 OH TYR H 60 -19.630 0. ,527 -15. 880 1. 00 37.17 H 0

ATOM 7566 CE2 TYR H 60 -20.990 2. 430 -16. 542 1.00 40.30 H c

ATOM 7568 CD2 TYR H 60 -21.070 3 . 705 -17. 156 1.00 41.49 H c

ATOM 7570 C TYR H 60 -19.649 8 . 114 -18. 135 1.00 43.51 H c

ATOM 7571 O TYR H 60 -20.724 8. 630 -18. 455 1.00 48.72 H 0

ATOM 7573 N ALA H 61 -18.453 8 . 663 -18. 394 1.00 39.52 H N

ATOM 7574 CA ALA H 61 -18.314 9. 770 -19. 367 1. 00 43.93 H c

ATOM 7576 CB ALA H 61 -16.870 10. ,281 -19. 472 1.00 30.30 H c

ATOM 7580 C ALA H 61 -18.799 9. 292 -20. 732 1.00 43.44 H c

ATOM 7581 O ALA H 61 -18.673 8 . 109 -21. 046 1. 00 42.24 H 0

ATOM 7583 N ASP H 62 -19.316 10. 219 -21. 542 1.00 47.04 H N

ATOM 7584 CA ASP H 62 -20.018 9. 892 -22. 795 1.00 49.58 H c

ATOM 7586 CB ASP H 62 -20.350 11. 153 -23. 600 1.00 54.89 H c

ATOM 7589 CG ASP H 62 -21.487 11. 955 -23. 016 1. 00 62.22 H c

ATOM 7590 ODl ASP H 62 -21.716 13. 061 -23. 548 1.00 65.69 H 0

ATOM 7591 OD2 ASP H 62 -22.150 11. 504 -22. 045 1.00 68.12 H 0

ATOM 7592 C ASP H 62 -19.240 8 . 987 -23. 722 1.00 50.77 H c

ATOM 7593 0 ASP H 62 -19.819 8 . 128 -24. 385 1.00 52.70 H 0

ATOM 7595 N ASP H 63 -17.941 9. 229 -23. 832 1.00 53.52 H N

ATOM 7596 CA ASP H 63 -17.090 8 . 339 -24. 587 1. 00 54.70 H c

ATOM 7598 CB ASP H 63 -15.623 8 . 795 -24. 534 1.00 59.08 H c

ATOM 7601 CG ASP H 63 -15.343 9. 977 -25. 457 1.00 65.05 H c

ATOM 7602 ODl ASP H 63 -14.409 9. 864 -26. 285 1.00 71.29 H 0

ATOM 7603 OD2 ASP H 63 -16.051 11.008 -25. 374 1.00 64.78 H 0

ATOM 7604 C ASP H 63 -17.336 6. 992 -23. 936 1.00 55.97 H c

ATOM 7605 0 ASP H 63 -18.417 6. 438 -24. 059 1.00 65.01 H 0

ATOM 7607 N PHE H 64 -16.371 6. 456 -23. 242 1.00 53.68 H N

ATOM 7608 CA PHE H 64 -16.541 5. 266 -22. 378 1.00 49.07 H C

ATOM 7610 CB PHE H 64 -15.792 5. 621 -21. 101 1. 00 43.07 H C

ATOM 7613 CG PHE H 64 -14.468 6. 256 -21. 408 1.00 39.83 H C

ATOM 7614 CDl PHE H 64 -13.487 5. 512 -22. 020 1.00 40.89 H c

ATOM 7616 CEl PHE H 64 -12.283 6. 082 -22. 363 1.00 41.59 H c

ATOM 7618 CZ PHE H 64 -12.064 7. 403 -22. 127 1.00 39.53 H c

ATOM 7620 CE2 PHE H 64 -13.055 8 . 168 -21. 556 1.00 41.42 H c

ATOM 7622 CD2 PHE H 64 -14.257 7. 607 -21.231 1.00 36.13 H c

ATOM 7624 C PHE H 64 -17. 888 4. 559 -22. 095 1.00 45.03 H c

ATOM 7625 0 PHE H 64 -17.949 3 . 712 -21. 215 1.00 42.22 H 0

ATOM 7627 N LYS H 65 -18.939 4. ,835 -22. 860 1.00 49.40 H N

ATOM 7628 CA LYS H 65 -20.220 4. ,127 -22. 704 1. 00 52.43 H c

ATOM 7630 CB LYS H 65 -21.396 5. 089 -22. 988 1.00 51.77 H c

ATOM 7633 CG LYS H 65 -21.591 6. 146 -21. 892 1. 00 52.27 H c

ATOM 7636 CD LYS H 65 -22.718 7. 135 -22. 234 1.00 52.59 H c

ATOM 7639 CE LYS H 65 -23.069 8 . 028 -21. 039 1.00 53.37 H c

ATOM 7642 NZ LYS H 65 -24.035 9. 149 -21. 372 1.00 56.07 H N

ATOM 7646 C LYS H 65 -20.284 2. ,865 -23. 595 1.00 51.32 H c

ATOM 7647 0 LYS H 65 -20.014 2. ,911 -24. 783 1.00 57.14 H 0

ATOM 7649 N GLY H 66 -20.622 1. ,729 -23. 015 1.00 52.70 H N

ATOM 7650 CA GLY H 66 -20.807 0. ,515 -23. 811 1. 00 52.02 H c

ATOM 7653 C GLY H 66 -19.810 -0. ,583 -23. 496 1. 00 49.51 H c

ATOM 7654 0 GLY H 66 -20.147 -1. 535 -22. 765 1. 00 49.25 H 0

ATOM 7656 N ARG H 67 -18.593 -0. 449 -24. 045 1. 00 48.43 H N

ATOM 7657 CA ARG H 67 -17.540 -1. ,471 -23. 922 1.00 45.13 H c

ATOM 7659 CB ARG H 67 -16.489 -1. ,243 -25. ,010 1.00 49.01 H c

ATOM 7662 CG ARG H 67 -17.027 -1. ,252 -26. ,425 1.00 50.37 H c

ATOM 7665 CD ARG H 67 -15.939 -1. ,428 -27. 496 1.00 47.48 H c

ATOM 7668 NE ARG H 67 -15.063 -0. ,259 -27. 624 1.00 46.18 H N

ATOM 7670 CZ ARG H 67 -13.796 -0. ,196 -27. 208 1.00 46.87 H c

ATOM 7671 NHl ARG H 67 -13.216 -1. 239 -26. 610 1. 00 47.13 H N

ATOM 7674 NH2 ARG H 67 -13.097 0. 918 -27. 396 1. 00 42.78 H N

ATOM 7677 C ARG H 67 -16.811 -1. ,484 -22. ,574 1.00 43.46 H C

ATOM 7678 0 ARG H 67 -15.995 -2. 384 -22. ,298 1. 00 43.15 H 0

ATOM 7680 N PHE H 68 -17.082 -0 . 485 -21. ,738 1.00 42.22 H N

ATOM 7681 CA PHE H 68 -16.359 -0. 320 -20. ,482 1.00 41.30 H C

ATOM 7683 CB PHE H 68 -15.761 1. 079 -20. 397 1.00 41.99 H C human fD_Fab

ATOM 7686 CG PHE H 68 -14. 911 1. 433 -21. 581 1.00 39. 74 H C

ATOM 7687 CDl PHE H 68 -13. 546 1. 311 -21. 529 1.00 43. 32 H C

ATOM 7689 CE1 PHE H 68 -12. 764 1. 641 -22. 634 1.00 44. 51 H C

ATOM 7691 CZ PHE H 68 -13. ,360 2. 090 -23. 803 1.00 41. 12 H C

ATOM 7693 CE2 PHE H 68 -14. .719 2. 217 -23. 859 1.00 42. 21 H c

ATOM 7695 CD2 PHE H 68 -15. 491 1. 887 -22. 753 1.00 41.06 H c

ATOM 7697 C PHE H 68 -17. 298 -0. 550 -19. 318 1.00 39. 49 H c

ATOM 7698 O PHE H 68 -18. 277 0. 165 -19. 185 1.00 40. 01 H 0

ATOM 7700 N VAL H 69 -16. ,978 -1. 527 -18. 474 1.00 34. 21 H N

ATOM 7701 CA VAL H 69 -17. ,807 -1. 869 -17. 346 1.00 34. 50 H c

ATOM 7703 CB VAL H 69 -18. 503 -3. 230 -17. 575 1.00 36. 75 H c

ATOM 7705 CGI VAL H 69 -19. 407 -3. 592 -16. 386 1.00 32. 54 H c

ATOM 7709 CG2 VAL H 69 -19. ,298 -3. 202 -18. 886 1.00 32. 85 H c

ATOM 7713 C VAL H 69 -17. ,030 -1. 875 -16. 003 1.00 36. 79 H c

ATOM 7714 O VAL H 69 -16. ,013 -2. 564 -15. 864 1.00 38. 02 H 0

ATOM 7716 N PHE H 70 -17. ,514 -1. 098 -15. 028 1.00 38. 27 H N

ATOM 7717 CA PHE H 70 -16. 940 -1. 110 -13. 684 1.00 36. 89 H c

ATOM 7719 CB PHE H 70 -16. 991 0. 273 -13. 014 1.00 37. 97 H c

ATOM 7722 CG PHE H 70 -16. 513 1. 413 -13. 883 1.00 37. 49 H c

ATOM 7723 CDl PHE H 70 -15. 379 1. 295 -14. 683 1.00 37. 10 H c

ATOM 7725 CEl PHE H 70 -14. 965 2. 340 -15. 475 1.00 34. 60 H c

ATOM 7727 CZ PHE H 70 -15. ,654 3. 518 -15. 461 1.00 38. 72 H c

ATOM 7729 CE2 PHE H 70 -16. ,773 3. 669 -14. 657 1.00 38. 62 H c

ATOM 7731 CD2 PHE H 70 -17. ,195 2. 616 -13. 877 1.00 38. 59 H c

ATOM 7733 C PHE H 70 -17. 687 -2. 121 -12. 810 1.00 39. 44 H c

ATOM 7734 O PHE H 70 -18. 894 -2. 287 -12. 939 1.00 43. 06 H 0

ATOM 7736 N SER H 71 -16. 959 -2. 785 -11. 911 1.00 40. 67 H N

ATOM 7737 CA SER H 71 -17. 557 -3. 732 -10. 970 1.00 38. 04 H c

ATOM 7739 CB SER H 71 -17. 685 -5. 118 -11. 605 1.00 36. 07 H c

ATOM 7742 OG SER H 71 -16. ,426 -5. 692 -11.912 1.00 42. 12 H 0

ATOM 7744 C SER H 71 -16. ,757 -3. 763 -9. 666 1.00 39. 17 H c

ATOM 7745 O SER H 71 -15. 708 -3. 092 -9. 530 1.00 37. 28 H 0

ATOM 7747 N LEU H 72 -17. 295 -4. 502 -8. 699 1.00 38. 22 H N

ATOM 7748 CA LEU H 72 -16. 768 -4. 551 -7. 346 1.00 41. 56 H c

ATOM 7750 CB LEU H 72 -17. 707 -3. 818 -6. 364 1.00 36. 01 H c

ATOM 7753 CG LEU H 72 -18. 133 -2. 370 -6. 637 1.00 38. 72 H c

ATOM 7755 CDl LEU H 72 -19. 197 -1. 915 -5. 658 1.00 33. 87 H c

ATOM 7759 CD2 LEU H 72 -16. 933 -1. 434 -6. 565 1.00 42. 67 H c

ATOM 7763 C LEU H 72 -16. 674 -5. 987 -6. 878 1.00 44. 49 H c

ATOM 7764 O LEU H 72 -17. 483 -6. 830 -7. 290 1.00 43. 02 H 0

ATOM 7766 N ASP H 73 -15. 690 -6. 247 -6. 019 1.00 44. 88 H N

ATOM 7767 CA ASP H 73 -15. 768 -7. 342 -5. 070 1.00 47. 36 H C

ATOM 7769 CB ASP H 73 -14. 851 -8. 519 -5. 423 1.00 47. 09 H c

ATOM 7772 CG ASP H 73 -15. 079 -9. 719 -4. 515 1.00 45. 19 H c

ATOM 7773 ODl ASP H 73 -15. 889 -9. 635 -3. 574 1.00 47. 55 H 0

ATOM 7774 OD2 ASP H 73 -14. ,453 - -10. 755 -4. 732 1.00 51. 84 H 0

ATOM 7775 C ASP H 73 -15. ,424 -6. 778 -3. 687 1.00 47. ,48 H c

ATOM 7776 O ASP H 73 -14. 252 -6. 682 -3. 284 1.00 45. ,49 H 0

ATOM 7778 N THR H 74 -16. 480 -6. 404 -2. 982 1.00 48. ,74 H N

ATOM 7779 CA THR H 74 -16. 418 -5. 804 -1. 663 1.00 50. 41 H c

ATOM 7781 CB THR H 74 -17. 869 -5. 492 -1. 227 1.00 50. 35 H c

ATOM 7783 OGl THR H 74 -18. 374 -4. 445 -2. 070 1.00 52. 92 H 0

ATOM 7785 CG2 THR H 74 -17. 941 -5. 063 0. 211 1.00 53. 62 H c

ATOM 7789 C THR H 74 -15. 732 -6. 668 -0. 602 1.00 54. ,47 H c

ATOM 7790 O THR H 74 -15. 102 -6. 146 0. 330 1.00 55. ,52 H 0

ATOM 7792 N SER H 75 -15. 854 -7. 983 -0. 756 1.00 55. ,70 H N

ATOM 7793 CA SER H 75 -15. 243 -8. 942 0. 164 1.00 54. ,19 H c

ATOM 7795 CB SER H 75 -15. 761 - -10. 359 -0. 146 1.00 55. ,37 H c

ATOM 7798 OG SER H 75 -15. 314 - -10. 810 -1. 411 1.00 50. 62 H 0

ATOM 7800 C SER H 75 -13. 702 -8. 879 0. 166 1.00 53. 11 H c

ATOM 7801 O SER H 75 -13. 074 -9. 078 1. 210 1.00 55. 62 H 0

ATOM 7803 N VAL H 76 -13. 112 -8. 570 -0. 994 1.00 53. 20 H N

ATOM 7804 CA VAL H 76 -11. 653 -8. 381 -1. 147 1.00 49. ,54 H c

ATOM 7806 CB VAL H 76 -11. 104 -9. 248 -2. 321 1.00 50. ,89 H c

ATOM 7808 CGI VAL H 76 -11. 159 - -10. 737 -1. 956 1.00 53. ,64 H c

ATOM 7812 CG2 VAL H 76 -11. 850 -8. 964 -3. 624 1.00 42. 57 H c

ATOM 7816 C VAL H 76 -11. 279 -6. 903 -1. 371 1.00 50. 15 H c

ATOM 7817 O VAL H 76 -10. 124 -6. 590 -1. 700 1.00 48. ,48 H 0 human fD_Fab

ATOM 7819 N SER H 77 -12. 265 -6. 014 -1. 171 1.00 48. 22 H N

ATOM 7820 CA SER H 77 -12. 145 -4. 561 -1. 355 1.00 42. 63 H C

ATOM 7822 CB SER H 77 -11. ,592 -3. 908 -0. 077 1.00 45. 66 H C

ATOM 7825 OG SER H 77 -10. 193 -3. 784 -0. 118 1.00 53. 93 H 0

ATOM 7827 C SER H 77 -11. ,402 -4. 179 -2. 666 1.00 38. 13 H C

ATOM 7828 O SER H 77 -10. ,471 -3. 362 -2. 684 1.00 33. 76 H 0

ATOM 7830 N THR H 78 -11. 857 -4. 794 -3. 763 1.00 36. 24 H N

ATOM 7831 CA THR H 78 -11.273 -4. 623 -5. 096 1.00 36. 51 H C

ATOM 7833 CB THR H 78 -10. 782 -5. 978 -5. 670 1.00 36. 43 H c

ATOM 7835 OGl THR H 78 -9. 825 -6. 550 -4. 774 1.00 41. 05 H 0

ATOM 7837 CG2 THR H 78 -10. 163 -5. 826 -7. 081 1.00 35. 83 H c

ATOM 7841 C THR H 78 -12. 321 -4. 058 -6. 036 1.00 35. 31 H c

ATOM 7842 O THR H 78 -13. 494 -4. 427 -5. 957 1.00 36. 20 H 0

ATOM 7844 N ALA H 79 -11. 882 -3. 145 -6. 901 1.00 35. 17 H N

ATOM 7845 CA ALA H 79 -12. 700 -2. 614 -7. 988 1.00 35. 93 H c

ATOM 7847 CB ALA H 79 -12. 774 -1. 118 -7. 934 1.00 33. 61 H c

ATOM 7851 C ALA H 79 -12. 087 -3. 082 -9. 298 1.00 35. 83 H c

ATOM 7852 O ALA H 79 -10. 890 -3. 310 -9. 370 1.00 34. 53 H 0

ATOM 7854 N TYR H 80 -12. 924 -3. 262 -10. 317 1.00 38. 14 H N

ATOM 7855 CA TYR H 80 -12. 489 -3. 829 -11. 590 1.00 37. 74 H c

ATOM 7857 CB TYR H 80 -13. 080 -5. 225 -11.780 1.00 40. 28 H c

ATOM 7860 CG TYR H 80 -12. 695 -6. 207 -10. 713 1.00 40. 76 H c

ATOM 7861 CDl TYR H 80 -11.510 -6. 967 -10. 822 1.00 41. 81 H c

ATOM 7863 CEl TYR H 80 -11. 146 -7. 878 -9. 835 1.00 37. 71 H c

ATOM 7865 CZ TYR H 80 -11. 975 -8. 043 -8. 732 1.00 42. 30 H c

ATOM 7866 OH TYR H 80 -11. 643 -8. 940 -7. 746 1.00 46. 15 H 0

ATOM 7868 CE2 TYR H 80 -13. 145 -7. 305 -8. 601 1.00 40. 06 H c

ATOM 7870 CD2 TYR H 80 -13. 502 -6. 395 -9. 599 1.00 40. 44 H c

ATOM 7872 C TYR H 80 -12. 946 -2. 982 -12. 746 1.00 36. 55 H c

ATOM 7873 O TYR H 80 -14. 025 -2. 403 -12. 703 1.00 39. 92 H 0

ATOM 7875 N LEU H 81 -12. 128 -2. 917 -13. 787 1.00 41.55 H N

ATOM 7876 CA LEU H 81 -12. 525 -2. 308 -15. 048 1.00 41. 25 H c

ATOM 7878 CB LEU H 81 -11. 556 -1. 186 -15. 432 1.00 43. 83 H c

ATOM 7881 CG LEU H 81 -11.650 -0. 664 -16. 872 1.00 41. 73 H c

ATOM 7883 CDl LEU H 81 -13. 006 -0. 019 -17. 115 1.00 34. 95 H c

ATOM 7887 CD2 LEU H 81 -10. 498 0. 305 -17. 130 1.00 40. 26 H c

ATOM 7891 C LEU H 81 -12. 486 -3. 396 -16. 097 1.00 42. 34 H c

ATOM 7892 O LEU H 81 -11. 446 -3. 966 -16. 336 1.00 41. 26 H 0

ATOM 7894 N GLN H 82 -13. 622 -3. 669 -16. 718 1.00 49. ,16 H N

ATOM 7895 CA GLN H 82 -13. 727 -4. 631 -17. 801 1.00 44. 88 H c

ATOM 7897 CB GLN H 82 -14. 975 -5. 478 -17. 591 1.00 51. 09 H c

ATOM 7900 CG GLN H 82 -15. 328 -6. 451 -18. 728 1.00 59. 70 H c

ATOM 7903 CD GLN H 82 -14. 912 -7. 872 -18. 435 1.00 64. 09 H c

ATOM 7904 OEl GLN H 82 -14. 027 -8. 420 -19. 103 1.00 70. 68 H 0

ATOM 7905 NE2 GLN H 82 -15. 529 -8. 473 -17. 417 1.00 63. 38 H N

ATOM 7908 C GLN H 82 -13. 853 -3. 827 -19. 077 1.00 41. 52 H C

ATOM 7909 O GLN H 82 -14. 709 -2. 947 -19. 157 1.00 41. ,03 H 0

ATOM 7911 N ILE H 83 -12. 983 -4. 106 -20. ,051 1.00 38. 81 H N

ATOM 7912 CA ILE H 83 -13. 063 -3. 525 -21. ,386 1.00 42. ,49 H C

ATOM 7914 CB ILE H 83 -11. 791 -2. 770 -21. ,770 1.00 39. 06 H C

ATOM 7916 CGI ILE H 83 -11. 323 -1. 899 -20. 594 1.00 37. ,92 H c

ATOM 7919 CDl ILE H 83 -10. 135 -0. 972 -20. 910 1.00 38. ,49 H c

ATOM 7923 CG2 ILE H 83 -12. 021 -1. 953 -23. 083 1.00 35. 20 H c

ATOM 7927 C ILE H 83 -13. 236 -4. 657 -22. 367 1.00 44. 98 H c

ATOM 7928 0 ILE H 83 -12. 481 -5. 633 -22. 317 1.00 46. ,70 H 0

ATOM 7930 N SER H 84 -14. 224 -4. 538 -23. ,250 1.00 47. ,83 H N

ATOM 7931 CA SER H 84 -14. 556 -5. 611 -24. ,194 1.00 50. ,12 H c

ATOM 7933 CB SER H 84 -15. 977 -6. 108 -23. ,943 1.00 55. ,64 H c

ATOM 7936 OG SER H 84 -16. 017 -6. 907 -22. ,770 1.00 61.42 H 0

ATOM 7938 C SER H 84 -14. 411 -5. 135 -25. ,627 1.00 49. ,84 H c

ATOM 7939 0 SER H 84 -14. 407 -3. 940 -25. 874 1.00 48. ,77 H 0

ATOM 7941 N SER H 85 -14. 289 -6. 081 -26. ,556 1.00 52. 28 H N

ATOM 7942 CA SER H 85 -14. 102 -5. 796 -27. 994 1.00 50. ,70 H c

ATOM 7944 CB SER H 85 -15. 393 -5. 301 -28. 637 1.00 50. ,51 H c

ATOM 7947 OG SER H 85 -16. ,312 -6. 368 -28. ,751 1.00 53. ,98 H 0

ATOM 7949 C SER H 85 -12. 923 -4. 836 -28. ,231 1.00 50. ,77 H c

ATOM 7950 0 SER H 85 -13. 018 -3. 828 -28. ,952 1.00 46. ,20 H 0

ATOM 7952 N LEU H 86 -11. 805 -5. 194 -27. ,610 1.00 50. ,77 H N human fD_Fab

ATOM 7953 CA LEU H 86 -10. 610 -4 363 -27. 557 1 00 47. 00 H C

ATOM 7955 CB LEU H 86 -9. 494 -5 130 -26. 799 1 00 45.31 H C

ATOM 7958 CG LEU H 86 -9. 113 -4 883 -25. 325 1 00 46.04 H C

ATOM 7960 CDl LEU H 86 -10. 143 -4 165 -24. 507 1 00 42.57 H C

ATOM 7964 CD2 LEU H 86 -8. 709 -6 161 -24. 609 1 00 47.45 H C

ATOM 7968 C LEU H 86 -10. 135 -3 962 -28. 969 1 00 48.89 H C

ATOM 7969 O LEU H 86 -10. 151 -4 774 -29. 892 1 00 50.16 H 0

ATOM 7971 N LYS H 87 -9. 729 -2 708 -29. 134 1 00 51.06 H N

ATOM 7972 CA LYS H 87 -9. 119 -2 253 -30. 375 1 00 52.45 H C

ATOM 7974 CB LYS H 87 -10. 035 -1 357 -31. 222 1 00 56.18 H C

ATOM 7977 CG LYS H 87 -10. 922 -0 375 -30. 486 1 00 58.96 H C

ATOM 7980 CD LYS H 87 -11. 916 0 209 -31. 472 1 00 61.55 H C

ATOM 7983 CE LYS H 87 -12. 812 1 290 -30. 877 1 00 66.30 H c

ATOM 7986 NZ LYS H 87 -14. 279 1 051 -31. 184 1 00 68.38 H N

ATOM 7990 C LYS H 87 -7. 795 -1 582 -30. 055 1 00 53.66 H c

ATOM 7991 O LYS H 87 -7. 499 -1 294 -28. 889 1 00 50.30 H 0

ATOM 7993 N ALA H 88 -7. 005 -1 366 -31.108 1 00 50.15 H N

ATOM 7994 CA ALA H 88 -5. 665 -0 786 -31. 007 1 00 48.90 H C

ATOM 7996 CB ALA H 88 -5. 118 -0 492 -32. 395 1 00 45.66 H C

ATOM 8000 C ALA H 88 -5. 648 0 488 -30. 185 1 00 48.76 H C

ATOM 8001 0 ALA H 88 -4. 756 0 699 -29. 364 1 00 50.77 H 0

ATOM 8003 N GLU H 89 -6. 652 1 329 -30. 419 1 00 48.32 H N

ATOM 8004 CA GLU H 89 -6. 749 2 638 -29. 785 1 00 46.73 H C

ATOM 8006 CB GLU H 89 -7. 817 3 530 -30. 452 1 00 55.88 H c

ATOM 8009 CG GLU H 89 -8. 823 2 838 -31.392 1 00 63.79 H c

ATOM 8012 CD GLU H 89 -8. 219 2 456 -32. 744 1 00 68.91 H c

ATOM 8013 OEl GLU H 89 -7. 574 3 328 -33. 379 1 00 70.31 H 0

ATOM 8014 OE2 GLU H 89 -8. 390 1 281 -33. 162 1 00 69.81 H 0

ATOM 8015 C GLU H 89 -6. 973 2 580 -28. 265 1 00 44.87 H c

ATOM 8016 0 GLU H 89 -6. 871 3 611 -27. 611 1 00 47.72 H 0

ATOM 8018 N ASP H 90 -7. 265 1 393 -27. 720 1 00 40.09 H N

ATOM 8019 CA ASP H 90 -7. 509 1 192 -26. 286 1 00 40.19 H c

ATOM 8021 CB ASP H 90 -8. 375 -0 057 -26. 039 1 00 36.37 H c

ATOM 8024 CG ASP H 90 -9. 807 0 141 -26. 443 1 00 40.71 H c

ATOM 8025 ODl ASP H 90 -10. 372 1 209 -26. 132 1 00 45.67 H 0

ATOM 8026 OD2 ASP H 90 -10. 392 -0 773 -27. 054 1 00 44.51 H 0

ATOM 8027 C ASP H 90 -6. 210 0 995 -25. 541 1 00 36.02 H c

ATOM 8028 0 ASP H 90 -6. 185 0 830 -24. 327 1 00 37.09 H 0

ATOM 8030 N THR H 91 -5. 132 0 912 -26. 284 1 00 37.59 H N

ATOM 8031 CA THR H 91 -3. 804 0 835 -25. 698 1 00 40.36 H c

ATOM 8033 CB THR H 91 -2. 707 0 681 -26. 806 1 00 42.84 H c

ATOM 8035 OG1 THR H 91 -2. 882 -0 584 -27. 484 1 00 40.04 H 0

ATOM 8037 CG2 THR H 91 -1. 284 0 803 -26 200 1 00 39.40 H c

ATOM 8041 C THR H 91 -3. 569 2 110 -24 872 1 00 41.02 H c

ATOM 8042 0 THR H 91 -3. 520 3 223 -25. 395 1 00 37.75 H 0

ATOM 8044 N ALA H 92 -3. 442 1 932 -23. 566 1 00 39.46 H N

ATOM 8045 CA ALA H 92 -3. 367 3 058 -22. 641 1 00 37.53 H c

ATOM 8047 CB ALA H 92 -4. 744 3 799 -22. 532 1 00 30.87 H c

ATOM 8051 C ALA H 92 -2. 975 2 550 -21. 282 1 00 38.57 H c

ATOM 8052 0 ALA H 92 -3. 007 1 349 -21. 009 1 00 42.27 H 0

ATOM 8054 N VAL H 93 -2. 601 3 485 -20. 424 1 00 42.81 H N

ATOM 8055 CA VAL H 93 -2. 492 3 219 -19 000 1 00 35.25 H c

ATOM 8057 CB VAL H 93 -1. 382 4 063 -18 343 1 00 34.09 H c

ATOM 8059 CGI VAL H 93 -1. 413 3 947 -16 789 1 00 28.67 H c

ATOM 8063 CG2 VAL H 93 -0. 014 3 650 -18 906 1 00 33.91 H c

ATOM 8067 C VAL H 93 -3. 838 3 549 -18 381 1 00 36.37 H c

ATOM 8068 0 VAL H 93 -4. 437 4 582 -18 669 1 00 37.24 H 0

ATOM 8070 N TYR H 94 -4. 312 2 652 -17 532 1 00 37.50 H N

ATOM 8071 CA TYR H 94 -5. 567 2 821 -16. 841 1 00 34.60 H c

ATOM 8073 CB TYR H 94 -6. 471 1 623 -17. 113 1 00 34.12 H c

ATOM 8076 CG TYR H 94 -6. 862 1 559 -18. 551 1 00 32.16 H c

ATOM 8077 CDl TYR H 94 -7. 962 2 248 -19 Oil 1 00 33.50 H c

ATOM 8079 CEl TYR H 94 -8. 327 2 196 -20 371 1 00 36.31 H c

ATOM 8081 CZ TYR H 94 -7. 561 1 464 -21 258 1 00 34.70 H c

ATOM 8082 OH TYR H 94 -7. 906 1 423 -22 595 1 00 36.69 H 0

ATOM 8084 CE2 TYR H 94 -6. 457 0 781 -20 812 1 00 30.57 H c

ATOM 8086 CD2 TYR H 94 -6. 103 0 842 -19 469 1 00 33.34 H c

ATOM 8088 C TYR H 94 -5. 281 2 926 -15 372 1 00 36.11 H c human fD_Fab

ATOM 8089 O TYR H 94 -4. ,601 2. 053 -14. 802 1.00 34. 38 H 0

ATOM 8091 N TYR H 95 -5. 786 4. 005 -14. 768 1.00 36. 22 H N

ATOM 8092 CA TYR H 95 -5. 649 4. 233 -13. 338 1.00 35. 02 H C

ATOM 8094 CB TYR H 95 -5. 144 5. 634 -13. 005 1.00 39. 99 H C

ATOM 8097 CG TYR H 95 -3. 834 6. 046 -13. 614 1.00 43. 50 H c

ATOM 8098 CDl TYR H 95 -2. 643 5. 807 -12. 951 1.00 43. 38 H c

ATOM 8100 CEl TYR H 95 -1. ,430 6. 209 -13. 495 1.00 41.50 H c

ATOM 8102 CZ TYR H 95 -1. 409 6. 853 -14. 711 1.00 41. 89 H c

ATOM 8103 OH TYR H 95 -0. 207 7. 245 -15. 227 1.00 44. 03 H 0

ATOM 8105 CE2 TYR H 95 -2. 584 7. 123 -15. 395 1.00 41. 94 H c

ATOM 8107 CD2 TYR H 95 -3. 789 6. 729 -14. 842 1.00 41. 79 H c

ATOM 8109 C TYR H 95 -6. 996 4. 109 -12. 654 1.00 34. 71 H c

ATOM 8110 O TYR H 95 -8. 035 4. 423 -13. 222 1.00 31. 25 H 0

ATOM 8112 N CYS H 96 -6. 951 3. 656 -11. 414 1.00 39. 13 H N

ATOM 8113 CA CYS H 96 -8. 030 3. 871 -10. 484 1.00 37. 29 H c

ATOM 8115 CB CYS H 96 -8. 329 2. 600 -9. 663 1.00 41.25 H c

ATOM 8118 SG CYS H 96 -7. 036 2. 010 -8. 498 1.00 43. 16 H s

ATOM 8120 C CYS H 96 -7. 578 5. 051 -9. 608 1.00 36. 44 H c

ATOM 8121 O CYS H 96 -6. 381 5. 211 -9. 333 1.00 34. 39 H 0

ATOM 8123 N GLU H 97 -8. 527 5. 922 -9. 274 1.00 35. 66 H N

ATOM 8124 CA GLU H 97 -8. 325 6. 997 -8. 313 1.00 34. 76 H c

ATOM 8126 CB GLU H 97 -8. 390 8. 365 -8. 990 1.00 35. 14 H C

ATOM 8129 CG GLU H 97 -8. 242 9. 545 -8. 002 1.00 37. 35 H C

ATOM 8132 CD GLU H 97 -8. 775 10. 884 -8. 537 1.00 40. 55 H C

ATOM 8133 OEl GLU H 97 -9. 769 10. 893 -9. 313 1.00 39. 27 H 0

ATOM 8134 OE2 GLU H 97 -8. 194 11.931 -8. 155 1.00 44. 29 H 0

ATOM 8135 C GLU H 97 -9. 448 6. 909 -7. 293 1.00 29. 71 H c

ATOM 8136 O GLU H 97 -10. 605 6. 921 -7. 689 1.00 30. 33 H 0

ATOM 8138 N ARG H 98 -9. 114 6. 830 -6. 001 1.00 27. 30 H N

ATOM 8139 CA ARG H 98 -10. 153 6. 873 -4. 940 1.00 31.99 H c

ATOM 8141 CB ARG H 98 -9. 667 6. 437 -3. 566 1.00 29. 04 H c

ATOM 8144 CG ARG H 98 -10. 707 6. 636 -2. 439 1.00 32. 88 H c

ATOM 8147 CD ARG H 98 -10. 160 6. 311 -1. 033 1.00 30. 87 H c

ATOM 8150 NE ARG H 98 -9. 391 7. 423 -0. 493 1.00 33. 11 H N

ATOM 8152 CZ ARG H 98 -9. 104 7. 606 0. 799 1.00 34. 99 H c

ATOM 8153 NHl ARG H 98 -9. 497 6. ,745 1. 712 1.00 42. 49 H N

ATOM 8156 NH2 ARG H 98 -8. 408 8. 659 1. 189 1.00 33. ,95 H N

ATOM 8159 C ARG H 98 -10. 720 8. 268 -4. 823 1.00 33. 05 H C

ATOM 8160 O ARG H 98 -10. 002 9. 273 -4. 833 1.00 32. 74 H 0

ATOM 8162 N GLU H 99 -12. 023 8. 323 -4. 667 1.00 35. 20 H N

ATOM 8163 CA GLU H 99 -12. 697 9. 593 -4. 714 1.00 36. 56 H C

ATOM 8165 CB GLU H 99 -13. 919 9. 449 -5. 638 1.00 33. 51 H C

ATOM 8168 CG GLU H 99 -14. 874 10. 610 -5. 658 1.00 35. 26 H c

ATOM 8171 CD GLU H 99 -14. 242 11. ,892 -6. ,173 1.00 38. ,27 H c

ATOM 8172 OEl GLU H 99 -13. 218 11. ,816 -6. 926 1.00 33. ,31 H 0

ATOM 8173 OE2 GLU H 99 -14. 782 12. ,970 -5. ,808 1.00 31. 39 H 0

ATOM 8174 C GLU H 99 -13. 193 10. 253 -3. ,439 1.00 40. ,17 H c

ATOM 8175 O GLU H 99 -14. 000 9. ,666 -2. ,711 1.00 47. ,04 H 0

ATOM 8177 N GLY H 100 -12. 576 11. ,375 -3. ,070 1.00 43. ,96 H N

ATOM 8178 CA GLY H 100 -12. 404 11. ,810 -1. ,711 1.00 41. ,52 H c

ATOM 8181 C GLY H 100 -11. 291 11. ,566 -0. 767 1.00 41. ,90 H c

ATOM 8182 0 GLY H 100 -10. 654 10. 542 -0. 780 1.00 47. ,55 H 0

ATOM 8184 N GLY H 101 -11. 136 12. ,538 0. ,124 1.00 40. ,92 H N

ATOM 8185 CA GLY H 101 -10. ,151 12. ,495 1. ,172 1.00 38. ,85 H c

ATOM 8188 C GLY H 101 -8. 811 12. ,874 0. ,585 1.00 40. ,15 H c

ATOM 8189 O GLY H 101 -8. ,740 13. ,476 -0. ,510 1.00 37. ,79 H 0

ATOM 8191 N VAL H 108 -7. 766 12. ,489 1. 322 1.00 36. ,77 H N

ATOM 8192 CA VAL H 108 -6. 403 12. ,589 0. ,892 1.00 33. ,64 H c

ATOM 8194 CB VAL H 108 -5. 476 12. ,042 2. ,002 1.00 33. ,69 H c

ATOM 8196 CGl VAL H 108 -4. 054 12. ,298 1. ,689 1.00 35. ,24 H c

ATOM 8200 CG2 VAL H 108 -5. 796 12. ,750 3. ,325 1.00 35. ,01 H c

ATOM 8204 C VAL H 108 -6. ,415 11. ,800 -0. ,405 1.00 32. ,82 H c

ATOM 8205 O VAL H 108 -6. ,894 10. ,659 -0. ,459 1.00 35. ,08 H 0

ATOM 8207 N ASN H 109 -5. 947 12. ,446 -1. ,465 1.00 32. ,62 H N

ATOM 8208 CA ASN H 109 -6. 112 11. ,919 -2. ,796 1.00 33. ,42 H c

ATOM 8210 CB ASN H 109 -6. ,000 13. 038 -3. ,815 1.00 36. ,24 H c

ATOM 8213 CG ASN H 109 -6. ,444 12. 619 -5. ,186 1.00 38. ,29 H c

ATOM 8214 ODl ASN H 109 -7. 599 12. 199 -5. ,399 1.00 45. ,32 H 0 human fD_Fab

ATOM 8215 ND2 ASN H 109 -5. 528 12. 713 -6. 132 1.00 36. 40 H N

ATOM 8218 C ASN H 109 -5. 106 10. 817 -3. 063 1.00 35. 11 H C

ATOM 8219 O ASN H 109 -3. 896 10. 996 -2. 878 1.00 30. 04 H 0

ATOM 8221 N ASN H 110 -5. 634 9. 668 -3. 490 1.00 38. 32 H N

ATOM 8222 CA ASN H 110 -4. 836 8. 475 -3. 709 1.00 36. 09 H C

ATOM 8224 CB ASN H 110 -5. 108 7. 444 -2. 596 1.00 36. 91 H C

ATOM 8227 CG ASN H 110 -4. 205 7. 617 -1. 398 1.00 38. 56 H C

ATOM 8228 OD1 ASN H 110 -3. 148 6. 971 -1. 298 1.00 44. 77 H 0

ATOM 8229 ND2 ASN H 110 -4. 616 8. 473 -0. 470 1.00 36. 28 H N

ATOM 8232 C ASN H 110 -5. 154 7. 853 -5. 060 1.00 34. 88 H C

ATOM 8233 O ASN H 110 -6. 316 7. 730 -5. 431 1.00 36. 48 H 0

ATOM 8235 N TRP H 111 -4. 100 7. 434 -5. 752 1.00 35. 16 H N

ATOM 8236 CA TRP H 111 -4. 175 6. 806 -7. 050 1.00 34. 91 H C

ATOM 8238 CB TRP H 111 -3. 408 7. 657 -8. 067 1.00 34. 76 H c

ATOM 8241 CG TRP H 111 -4. 151 8. 860 -8. 463 1.00 35. 84 H c

ATOM 8242 CDl TRP H 111 -4. 529 9. 894 -7. 656 1.00 36. 17 H c

ATOM 8244 NEl TRP H 111 -5. 229 10. 822 -8. 378 1.00 35. 97 H N

ATOM 8246 CE2 TRP H 111 -5. 338 10. 385 -9. 677 1.00 36. 89 H c

ATOM 8247 CD2 TRP H 111 -4. 664 9. 155 -9. 766 1.00 34. 84 H c

ATOM 8248 CE3 TRP H 111 -4. 605 8. 508 -10. 997 1.00 38. 25 H c

ATOM 8250 CZ3 TRP H 111 -5. 209 9. 105 -12. 095 1.00 36. 65 H c

ATOM 8252 CH2 TRP H 111 -5. 871 10. 331 -11. 977 1.00 36. 07 H c

ATOM 8254 CZ2 TRP H 111 -5. 942 10. 989 -10. 783 1.00 35. 02 H c

ATOM 8256 C TRP H 111 -3. 524 5. 447 -6. 967 1.00 37. 71 H c

ATOM 8257 O TRP H 111 -2. 569 5. 240 -6. 179 1.00 31.90 H 0

ATOM 8259 N GLY H 112 -4. 033 4. 518 -7. 783 1.00 35. 70 H N

ATOM 8260 CA GLY H 112 -3. 269 3. 329 -8. 120 1.00 37. 62 H c

ATOM 8263 C GLY H 112 -2. 118 3. 684 -9. 027 1.00 38. 02 H c

ATOM 8264 O GLY H 112 -2. 054 4. 802 -9. 564 1.00 36. 55 H 0

ATOM 8266 N GLN H 113 -1. 226 2. 717 -9. 228 1.00 36. 06 H N

ATOM 8267 CA GLN H 113 0. 019 2. 961 -9. 946 1.00 33. 03 H c

ATOM 8269 CB GLN H 113 1. 135 2. 026 -9. 391 1.00 33. 37 H c

ATOM 8272 CG GLN H 113 1. 136 0. 570 -9. 836 1.00 36. 35 H c

ATOM 8275 CD GLN H 113 0. 078 -0. 335 -9. 172 1.00 35. 12 H c

ATOM 8276 OEl GLN H 113 -0. 846 0. 119 -8. 485 1.00 37. 69 H 0

ATOM 8277 NE2 GLN H 113 0. 213 -1. 628 -9. 409 1.00 30. 39 H N

ATOM 8280 C GLN H 113 -0. 172 2. 933 -11. 474 1.00 36. 45 H c

ATOM 8281 O GLN H 113 0. 694 3. 424 -12. 231 1.00 36. 80 H 0

ATOM 8283 N GLY H 114 -1. 331 2. 446 -11. 927 1.00 37. 39 H N

ATOM 8284 CA GLY H 114 -1. 606 2. 306 -13. 365 1.00 36. 71 H c

ATOM 8287 C GLY H 114 -1. 391 0. 897 -13. 899 1.00 39. 39 H C

ATOM 8288 O GLY H 114 -0. 622 0. 119 -13. 338 1.00 39. 14 H 0

ATOM 8290 N THR H 115 -2. 100 0. 577 -14. 976 1.00 35. 67 H N

ATOM 8291 CA THR H 115 -1. 999 -0. 701 -15. 657 1.00 37. 44 H C

ATOM 8293 CB THR H 115 -3. 229 -1. 627 -15. 327 1.00 34. 83 H C

ATOM 8295 OGl THR H 115 -3. 320 -1. 829 -13. 899 1.00 32. 32 H 0

ATOM 8297 CG2 THR H 115 -3. 109 -2. 969 -16. 031 1.00 31. 86 H C

ATOM 8301 C THR H 115 -1. 925 -0. 390 -17. 135 1.00 35. 26 H C

ATOM 8302 O THR H 115 -2. 832 0. 227 -17. 672 1.00 34. 11 H 0

ATOM 8304 N LEU H 116 -0. 822 -0. 767 -17. 782 1.00 40. 12 H N

ATOM 8305 CA LEU H 116 -0. 690 -0. 566 -19. 221 1.00 39. 95 H C

ATOM 8307 CB LEU H 116 0. 782 -0. 439 -19. 614 1.00 39. 97 H c

ATOM 8310 CG LEU H 116 1. 105 -0. 280 -21.106 1.00 41.28 H c

ATOM 8312 CDl LEU H 116 0. 268 0. 775 -21. 802 1.00 40. 18 H c

ATOM 8316 CD2 LEU H 116 2. 556 0. 058 -21. 235 1.00 46. 77 H c

ATOM 8320 C LEU H 116 -1. 346 -1. 760 -19. 877 1.00 41.81 H c

ATOM 8321 O LEU H 116 -0. 940 -2. 891 -19. 640 1.00 45. 01 H 0

ATOM 8323 N VAL H 117 -2. 384 -1. 509 -20. 666 1.00 44. 17 H N

ATOM 8324 CA VAL H 117 -2. 965 -2. 537 -21. 506 1.00 39. 99 H c

ATOM 8326 CB VAL H 117 -4. 492 -2. 599 -21. 315 1.00 41. 79 H c

ATOM 8328 CGI VAL H 117 -5. 138 -3. 464 -22. 398 1.00 36. 30 H c

ATOM 8332 CG2 VAL H 117 -4. 854 -3. 086 -19. 833 1.00 31. 57 H c

ATOM 8336 C VAL H 117 -2. 536 -2. 201 -22. 935 1.00 41. 57 H c

ATOM 8337 O VAL H 117 -2. 779 -1. 104 -23. 388 1.00 42. 32 H 0

ATOM 8339 N THR H 118 -1. 828 -3. 132 -23. 601 1.00 44. 82 H N

ATOM 8340 CA THR H 118 -1. 490 -3. 034 -25. 032 1.00 44. 05 H c

ATOM 8342 CB THR H 118 -0. 007 -3. 448 -25. 271 1.00 43. 87 H c

ATOM 8344 OGl THR H 118 0. 845 -2. 767 -24. 339 1.00 41. 97 H 0 human fD_Fab

ATOM 8346 CG2 THR H 118 0. 449 -3. 132 -26. ,676 1.00 41. ,90 H C

ATOM 8350 C THR H 118 -2. 444 -3. 922 -25. ,844 1.00 43. 78 H C

ATOM 8351 O THR H 118 -2. 684 -5. 047 -25. ,466 1.00 42. 54 H 0

ATOM 8353 N VAL H 119 -3. 021 -3. 398 -26. ,929 1.00 48. 16 H N

ATOM 8354 CA VAL H 119 -3. 911 -4. 193 -27. ,788 1.00 47. 41 H C

ATOM 8356 CB VAL H 119 -5. 288 -3. 547 -28. ,035 1.00 44. 41 H C

ATOM 8358 CGI VAL H 119 -6. ,124 -4. 491 -28. ,891 1.00 41. ,97 H c

ATOM 8362 CG2 VAL H 119 -6. 000 -3. 210 -26. ,716 1.00 35. ,77 H c

ATOM 8366 C VAL H 119 -3. 245 -4. 413 -29. ,131 1.00 47. 62 H c

ATOM 8367 0 VAL H 119 -3. 167 -3. 486 -29. ,909 1.00 46. ,52 H 0

ATOM 8369 N SER H 120 -2. 797 -5. 649 -29. ,382 1.00 49. 23 H N

ATOM 8370 CA SER H 120 -2. 001 -5. 995 -30. ,571 1.00 49. ,64 H c

ATOM 8372 CB SER H 120 -0. 531 -5. 663 -30. ,314 1.00 52. ,13 H c

ATOM 8375 OG SER H 120 0. 264 -5. 865 -31. ,475 1.00 56. ,16 H 0

ATOM 8377 C SER H 120 -2. 103 -7. 476 -30. ,947 1.00 46. 46 H c

ATOM 8378 O SER H 120 -2. 204 -8. 329 -30. ,073 1.00 46. 52 H 0

ATOM 8380 N SER H 121 -2. 061 -7. 766 -32. ,251 1.00 49. 63 H N

ATOM 8381 CA SER H 121 -1. 971 -9. ,149 -32. ,751 1.00 50. ,00 H c

ATOM 8383 CB SER H 121 -2. 407 -9. 223 -34. ,224 1.00 51. ,79 H c

ATOM 8386 OG SER H 121 -1. 549 -8. 449 -35. 060 1.00 57. ,61 H 0

ATOM 8388 C SER H 121 -0. 544 -9. 747 -32. ,568 1.00 46. ,41 H c

ATOM 8389 0 SER H 121 -0. 348 -10. 953 -32. 669 1.00 45. ,92 H 0

ATOM 8391 N ALA H 122 0. 440 -8. 892 -32. 291 1.00 46. ,62 H N

ATOM 8392 CA ALA H 122 1. 810 -9. 339 -32. ,085 1.00 45. ,86 H c

ATOM 8394 CB ALA H 122 2. 786 -8. 140 -32. ,185 1.00 44. ,27 H c

ATOM 8398 C ALA H 122 1. 943 -10. 060 -30. ,752 1.00 48. ,21 H c

ATOM 8399 O ALA H 122 1. 237 -9. 748 -29. ,811 1.00 51. 02 H 0

ATOM 8401 N SER H 123 2. 851 -11. 035 -30. ,682 1.00 48. 89 H N

ATOM 8402 CA SER H 123 3. 001 -11. 866 -29. ,494 1.00 47. ,49 H C

ATOM 8404 CB SER H 123 3. 209 -13. 331 -29. 890 1.00 53. 26 H C

ATOM 8407 OG SER H 123 4. 498 -13. 556 -30. ,387 1.00 53. ,60 H 0

ATOM 8409 C SER H 123 4. 108 -11. ,378 -28. ,556 1.00 48. ,02 H c

ATOM 8410 O SER H 123 4. 996 -10. 593 -28. ,955 1.00 46. 30 H 0

ATOM 8412 N THR H 124 4. Oil -11.825 -27. 296 1.00 45. ,73 H N

ATOM 8413 CA THR H 124 4. 950 -11. 460 -26. ,226 1.00 45. ,97 H c

ATOM 8415 CB THR H 124 4. 468 -12. 039 -24. ,868 1.00 45. 36 H c

ATOM 8417 OGl THR H 124 3. 178 -11. 490 -24. ,557 1.00 54. ,73 H 0

ATOM 8419 CG2 THR H 124 5. 435 -11.693 -23. ,749 1.00 44. ,63 H c

ATOM 8423 C THR H 124 6. 399 -11. 921 -26. ,493 1.00 46. ,03 H c

ATOM 8424 O THR H 124 6. 634 -13. ,079 -26. ,815 1.00 43. ,24 H 0

ATOM 8426 N LYS H 125 7. 354 -10. 998 -26. ,356 1.00 46. ,51 H N

ATOM 8427 CA LYS H 125 8. 780 -11. ,312 -26. ,419 1.00 44. .43 H c

ATOM 8429 CB LYS H 125 9. 362 -10. ,869 -27. ,773 1.00 47. ,29 H c

ATOM 8432 CG LYS H 125 10. 867 -11. ,145 -27. ,978 1.00 46. .78 H c

ATOM 8435 CD LYS H 125 11. 217 -12. 644 -27. ,970 1.00 47. ,36 H c

ATOM 8438 CE LYS H 125 12. 719 -12. 886 -27. ,845 1.00 46. ,96 H c

ATOM 8441 NZ LYS H 125 13. 225 -12. ,815 -26. ,402 1.00 44. ,86 H N

ATOM 8445 C LYS H 125 9. 516 -10. ,605 -25. ,280 1.00 42. ,72 H c

ATOM 8446 0 LYS H 125 9. 400 -9. 395 -25. ,104 1.00 42. ,10 H 0

ATOM 8448 N GLY H 126 10. 288 -11. ,364 -24. ,519 1.00 42. .29 H N

ATOM 8449 CA GLY H 126 11. 110 -10. ,801 -23. ,468 1.00 41. .31 H C

ATOM 8452 C GLY H 126 12. 338 -10. ,134 -24. ,062 1.00 39. .53 H C

ATOM 8453 O GLY H 126 12. 746 -10. ,466 -25. ,161 1.00 40. .73 H 0

ATOM 8455 N PRO H 127 12. 952 -9. ,202 -23. ,322 1.00 38. ,71 H N

ATOM 8456 CA PRO H 127 14. 101 -8. ,476 -23. ,849 1.00 40. ,86 H C

ATOM 8458 CB PRO H 127 14. 183 -7. ,258 -22. ,930 1.00 38. .60 H c

ATOM 8461 CG PRO H 127 13. 730 -7. ,777 -21. ,610 1.00 36. ,71 H c

ATOM 8464 CD PRO H 127 12. 633 -8. ,781 -21. ,947 1.00 40. ,01 H c

ATOM 8467 C PRO H 127 15. 395 -9. 273 -23. ,748 1.00 43. ,32 H c

ATOM 8468 O PRO H 127 15. 507 -10. ,181 -22. .902 1.00 45. ,48 H 0

ATOM 8469 N SER H 128 16. 339 -8. ,943 -24. ,626 1.00 43. .60 H N

ATOM 8470 CA SER H 128 17. 725 -9. ,373 -24. ,497 1.00 44. ,17 H c

ATOM 8472 CB SER H 128 18. 271 -9. ,767 -25. .860 1.00 43. .32 H c

ATOM 8475 OG SER H 128 17. 281 -10. ,482 -26. ,568 1.00 43. .03 H 0

ATOM 8477 C SER H 128 18. 495 -8. ,194 -23. ,933 1.00 42, .72 H c

ATOM 8478 O SER H 128 18. 327 -7. ,084 -24. ,402 1.00 45, ,87 H 0

ATOM 8480 N VAL H 129 19. 299 -8. ,428 -22. ,906 1.00 44. .34 H N

ATOM 8481 CA VAL H 129 19. 958 -7. ,348 -22. ,180 1.00 44. .40 H c human fD_Fab

ATOM 8483 CB VAL H 129 19. 663 -7. 403 -20. 677 1.00 40. 33 H C

ATOM 8485 CGI VAL H 129 20. ,239 -6. ,174 -19. ,980 1.00 37. ,67 H C

ATOM 8489 CG2 VAL H 129 18. ,158 -7. ,555 -20. ,434 1.00 30. ,14 H C

ATOM 8493 C VAL H 129 21. 453 -7. 442 -22. ,434 1. 00 47. ,64 H C

ATOM 8494 O VAL H 129 22. 057 -8. 495 -22. ,249 1.00 54. ,01 H 0

ATOM 8496 N PHE H 130 22. 028 -6. 326 -22. 881 1. 00 47. 33 H N

ATOM 8497 CA PHE H 130 23. 420 -6. 243 -23. 308 1.00 43. 32 H C

ATOM 8499 CB PHE H 130 23. 520 -5. 986 -24. 820 1.00 37. 55 H C

ATOM 8502 CG PHE H 130 22. ,906 -7. ,071 -25. ,668 1. 00 38. ,88 H c

ATOM 8503 CDl PHE H 130 23. 451 -8. 333 -25. ,703 1.00 39. ,93 H c

ATOM 8505 CEl PHE H 130 22. 877 -9. 322 -26. ,472 1. 00 37. ,55 H c

ATOM 8507 CZ PHE H 130 21. 774 -9. 057 -27. 207 1.00 34. ,12 H c

ATOM 8509 CE2 PHE H 130 21. 242 -7. 807 -27. 213 1. 00 35. 71 H c

ATOM 8511 CD2 PHE H 130 21. 802 -6. 821 -26. 448 1.00 37. 91 H c

ATOM 8513 C PHE H 130 24. 106 -5. 099 -22. 591 1.00 44. 96 H c

ATOM 8514 O PHE H 130 23. 546 -4. 012 -22. ,460 1.00 45. ,58 H 0

ATOM 8516 N PRO H 131 25. 342 -5. 323 -22. ,146 1. 00 46. ,34 H N

ATOM 8517 CA PRO H 131 26. 021 -4. 258 -21. 416 1.00 45. 99 H c

ATOM 8519 CB PRO H 131 27. 213 -4. 973 -20. 802 1.00 47. ,36 H c

ATOM 8522 CG PRO H 131 27. 525 -6. 074 -21. 804 1.00 49. 65 H c

ATOM 8525 CD PRO H 131 26. 184 -6. 521 -22. 320 1. 00 45. 87 H c

ATOM 8528 C PRO H 131 26. 505 -3. 158 -22. 359 1.00 46. 06 H c

ATOM 8529 O PRO H 131 26. 911 -3. 437 -23. ,483 1.00 50. ,40 H 0

ATOM 8530 N LEU H 132 26. 407 -1. 915 -21. ,904 1.00 43. 52 H N

ATOM 8531 CA LEU H 132 27. 095 -0. 801 -22. 530 1. 00 42. 28 H c

ATOM 8533 CB LEU H 132 26. 149 0. 374 -22. 738 1.00 38. 65 H c

ATOM 8536 CG LEU H 132 24. 992 0. 189 -23. 730 1. 00 34. 97 H c

ATOM 8538 CDl LEU H 132 23. 957 1. 305 -23. 531 1.00 35. 43 H c

ATOM 8542 CD2 LEU H 132 25. 509 0. 214 -25. 148 1.00 31. 92 H c

ATOM 8546 C LEU H 132 28. 260 -0. 457 -21. 592 1.00 42. 78 H c

ATOM 8547 O LEU H 132 28. 139 0. 368 -20. ,676 1.00 44. 18 H 0

ATOM 8549 N ALA H 133 29. 373 -1. 147 -21. ,816 1.00 47. 75 H N

ATOM 8550 CA ALA H 133 30. 551 -1. 102 -20. 947 1.00 48. 53 H c

ATOM 8552 CB ALA H 133 31.662 -2. 066 -21.488 1. 00 44. 30 H c

ATOM 8556 C ALA H 133 31. 131 0. 299 -20. 825 1.00 47. 84 H c

ATOM 8557 0 ALA H 133 31. 058 1. 087 -21.761 1. 00 49. 21 H 0

ATOM 8559 N PRO H 134 31. 731 0. 610 -19. 672 1.00 51. 22 H N

ATOM 8560 CA PRO H 134 32. 427 1. 878 -19. ,579 1.00 56. ,12 H c

ATOM 8562 CB PRO H 134 32. 648 2. 040 -18. ,081 1.00 55. ,78 H c

ATOM 8565 CG PRO H 134 32. 788 0. 634 -17. ,576 1. 00 54. ,55 H c

ATOM 8568 CD PRO H 134 31. 852 -0. 185 -18. ,436 1.00 54. 64 H c

ATOM 8571 C PRO H 134 33. 761 1. 730 -20. 287 1. 00 61. 07 H c

ATOM 8572 0 PRO H 134 34. 434 0. 704 -20. 149 1.00 64. 73 H 0

ATOM 8573 N SER H 135 34. 145 2. 730 -21.055 1. 00 65. 21 H N

ATOM 8574 CA SER H 135 35. 445 2. 700 -21. 705 1.00 69. ,82 H C

ATOM 8576 CB SER H 135 35. 296 2. 247 -23. ,169 1. 00 75. ,57 H C

ATOM 8579 OG SER H 135 34. 097 2. 724 -23. 774 1. 00 78. ,77 H 0

ATOM 8581 C SER H 135 36. 092 4. 064 -21. 621 1. 00 73. ,31 H C

ATOM 8582 0 SER H 135 35. 507 5. 007 -21. 076 1. 00 72. ,91 H 0

ATOM 8584 N SER H 136 37. 306 4. 174 -22. 154 1.00 78. 87 H N

ATOM 8585 CA SER H 136 37. 909 5. 496 -22. ,395 1. 00 78. 82 H C

ATOM 8587 CB SER H 136 39. 328 5. 370 -22. ,948 1.00 80. 85 H c

ATOM 8590 OG SER H 136 39. 795 6. ,632 -23. ,402 1. 00 83. 33 H 0

ATOM 8592 C SER H 136 37. 030 6. 324 -23. 363 1. 00 81. 81 H c

ATOM 8593 0 SER H 136 36. 948 7. 558 -23. ,243 1.00 83. 39 H 0

ATOM 8595 N LYS H 137 36. 360 5. 629 -24. ,294 1. 00 81. 77 H N

ATOM 8596 CA LYS H 137 35. 405 6. 253 -25. 227 1.00 80. 20 H c

ATOM 8598 CB LYS H 137 35. 084 5. 305 -26. ,405 1.00 79. ,96 H c

ATOM 8601 CG LYS H 137 36. 273 4. 671 -27. ,130 1.00 78. ,99 H c

ATOM 8604 CD LYS H 137 37. 098 5. ,680 -27. ,907 1.00 80. ,23 H c

ATOM 8607 CE LYS H 137 38. 059 4. ,978 -28. ,896 1. 00 80. 65 H c

ATOM 8610 NZ LYS H 137 39. 106 4. 112 -28. ,249 1. 00 78. ,44 H N

ATOM 8614 C LYS H 137 34. 091 6. 638 -24. ,517 1. 00 77. ,67 H c

ATOM 8615 0 LYS H 137 33. 136 7. 112 -25. ,167 1. 00 70. 96 H 0

ATOM 8617 N SER H 138 34. 049 6. 396 -23. ,201 1. 00 79. 02 H N

ATOM 8618 CA SER H 138 32. 908 6. 725 -22. ,347 1.00 79. ,60 H c

ATOM 8620 CB SER H 138 32. 045 5. ,475 -22. ,144 1. 00 77. ,51 H c

ATOM 8623 OG SER H 138 31. 867 5. ,192 -20. ,768 1. 00 77. ,09 H 0 human fD_Fab

ATOM 8625 C SER H 138 33.294 7. 337 -20. 976 1.00 80. ,08 H C

ATOM 8626 O SER H 138 32.448 7. 436 -20. 072 1.00 77. ,53 H 0

ATOM 8628 N THR H 139 34.559 7. 741 -20. 825 1.00 81. ,86 H N

ATOM 8629 CA THR H 139 35.013 8. 479 -19. 633 1.00 83. 05 H C

ATOM 8631 CB THR H 139 36.479 8. 060 -19. 175 1.00 83. ,13 H C

ATOM 8633 OG1 THR H 139 36.527 6. 653 -18. 864 1.00 79. 56 H 0

ATOM 8635 CG2 THR H 139 36.958 8. 872 -17. 945 1.00 79. ,07 H c

ATOM 8639 C THR H 139 34.913 9. 993 -19. 934 1.00 84. ,14 H c

ATOM 8640 O THR H 139 34.933 10. 412 -21. 105 1.00 84. 01 H 0

ATOM 8642 N SER H 140 34.768 10. 790 -18. 876 1.00 83. 65 H N

ATOM 8643 CA SER H 140 34.610 12. 232 -18. 997 1.00 84. ,11 H c

ATOM 8645 CB SER H 140 33.116 12. 566 -19. 119 1.00 87. ,28 H c

ATOM 8648 OG SER H 140 32.318 11. 706 -18. 329 1.00 91. ,86 H 0

ATOM 8650 C SER H 140 35.230 12. 957 -17. 795 1.00 83. ,42 H c

ATOM 8651 O SER H 140 34.544 13. 233 -16. 807 1.00 81. ,47 H 0

ATOM 8653 N GLY H 141 36.521 13. 281 -17. 903 1.00 84. ,14 H N

ATOM 8654 CA GLY H 141 37.309 13. 723 -16. 750 1.00 83. 18 H c

ATOM 8657 C GLY H 141 37.385 12. 602 -15. 714 1.00 84. 46 H c

ATOM 8658 O GLY H 141 38.023 11. 561 -15. 943 1.00 87. ,72 H 0

ATOM 8660 N GLY H 142 36.719 12. 803 -14. 579 1.00 79. ,83 H N

ATOM 8661 CA GLY H 142 36.615 11. 767 -13. 560 1.00 76. ,15 H c

ATOM 8664 C GLY H 142 35.314 10. 983 -13. 638 1.00 73. ,07 H c

ATOM 8665 O GLY H 142 35.081 10. 122 -12. 796 1.00 72. ,55 H 0

ATOM 8667 N THR H 143 34.486 11.268 -14. 648 1.00 70. 20 H N

ATOM 8668 CA THR H 143 33.156 10. 670 -14. 798 1.00 67. 07 H c

ATOM 8670 CB THR H 143 32.133 11. 781 -15. 066 1.00 70. ,83 H c

ATOM 8672 OGl THR H 143 32.306 12. 814 -14. 087 1.00 73. 93 H 0

ATOM 8674 CG2 THR H 143 30.697 11. 250 -15. 005 1.00 71. ,41 H c

ATOM 8678 C THR H 143 33.106 9. 630 -15. 934 1.00 64. ,83 H c

ATOM 8679 O THR H 143 33.472 9. 927 -17. 073 1.00 65. 33 H 0

ATOM 8681 N ALA H 144 32.664 8. 410 -15. 626 1.00 61. ,30 H N

ATOM 8682 CA ALA H 144 32.466 7. 373 -16. 650 1.00 56.92 H c

ATOM 8684 CB ALA H 144 33.199 6. 095 -16. 270 1.00 54. 56 H c

ATOM 8688 C ALA H 144 30.988 7. 089 -16. 870 1.00 54. ,17 H c

ATOM 8689 O ALA H 144 30.242 6. 964 -15. 909 1.00 55. ,41 H 0

ATOM 8691 N ALA H 145 30.575 6. 999 -18. 134 1.00 50. ,55 H N

ATOM 8692 CA ALA H 145 29.219 6. 600 -18. 499 1.00 47. ,56 H c

ATOM 8694 CB ALA H 145 28.753 7. 367 -19. 741 1.00 43. ,41 H c

ATOM 8698 C ALA H 145 29.157 5. 098 -18. 777 1.00 48. 05 H c

ATOM 8699 O ALA H 145 30.030 4. 562 -19. 459 1.00 48. 66 H 0

ATOM 8701 N LEU H 146 28.112 4. 432 -18. 270 1.00 46. 22 H N

ATOM 8702 CA LEU H 146 27.830 3. 025 -18. 616 1.00 45. ,39 H c

ATOM 8704 CB LEU H 146 28.468 2. 049 -17. 614 1.00 49. ,59 H c

ATOM 8707 CG LEU H 146 28.201 2. 235 -16. 118 1.00 50. 31 H c

ATOM 8709 CDl LEU H 146 26.969 1. 451 -15. 666 1.00 52. ,95 H c

ATOM 8713 CD2 LEU H 146 29.415 1. ,805 -15. 313 1.00 49. ,61 H c

ATOM 8717 C LEU H 146 26.344 2. 790 -18. 709 1.00 43. ,31 H c

ATOM 8718 O LEU H 146 25.557 3. 650 -18. 315 1.00 44. ,23 H 0

ATOM 8720 N GLY H 147 25.953 1. 630 -19. 232 1.00 44. ,00 H N

ATOM 8721 CA GLY H 147 24.533 1. ,302 -19. ,337 1.00 43. ,01 H c

ATOM 8724 C GLY H 147 24.156 -0. ,120 -19. 697 1.00 41. ,62 H c

ATOM 8725 O GLY H 147 24.953 -1. 068 -19. 563 1.00 36. ,99 H 0

ATOM 8727 N CYS H 148 22.906 -0. 256 -20. 130 1.00 44. ,05 H N

ATOM 8728 CA CYS H 148 22.369 -1. 522 -20. ,620 1.00 42. ,28 H c

ATOM 8730 CB CYS H 148 21.615 -2. ,286 -19. 515 1.00 44. ,19 H c

ATOM 8733 SG CYS H 148 22.726 -3. 180 -18. 379 1.00 49. ,43 H s

ATOM 8735 C CYS H 148 21.455 -1. ,267 -21. ,814 1.00 39. ,10 H c

ATOM 8736 O CYS H 148 20.625 -0. 369 -21. ,788 1.00 39. ,14 H 0

ATOM 8738 N LEU H 149 21.629 -2. 063 -22. ,857 1.00 36. ,07 H N

ATOM 8739 CA LEU H 149 20.707 -2. 102 -23. 987 1.00 36. ,55 H c

ATOM 8741 CB LEU H 149 21.466 -2. 405 -25. 273 1.00 36. ,46 H c

ATOM 8744 CG LEU H 149 20.749 -2. 461 -26. 630 1.00 37. ,06 H c

ATOM 8746 CDl LEU H 149 19.956 -1. 182 -26. 990 1.00 34. ,85 H c

ATOM 8750 CD2 LEU H 149 21.799 -2. 789 -27. 691 1.00 36. ,54 H c

ATOM 8754 C LEU H 149 19.661 -3. ,172 -23. 747 1.00 40. ,19 H c

ATOM 8755 O LEU H 149 19.979 -4. 358 -23. 643 1.00 37, .51 H 0

ATOM 8757 N VAL H 150 18.411 -2. 731 -23. 604 1.00 39. ,59 H N

ATOM 8758 CA VAL H 150 17.303 -3. 616 -23. 381 1.00 36. ,69 H c human fD_Fab

ATOM 8760 CB VAL H 150 16 393 -3. 069 -22 319 1.00 33 37 H C

ATOM 8762 CGI VAL H 150 15 295 -4. 062 -22 067 1.00 30 88 H C

ATOM 8766 CG2 VAL H 150 17 218 -2. 785 -21 079 1.00 30 65 H C

ATOM 8770 C VAL H 150 16 580 -3. 716 -24 694 1.00 37. 50 H c

ATOM 8771 O VAL H 150 15 776 -2. 851 -25 030 1.00 38. 91 H 0

ATOM 8773 N LYS H 151 16 833 -4. 809 -25 408 1.00 39. 40 H N

ATOM 8774 CA LYS H 151 16 505 -4. 885 -26 811 1.00 40. 07 H c

ATOM 8776 CB LYS H 151 17 772 -5. 131 -27 621 1.00 43. 23 H c

ATOM 8779 CG LYS H 151 17 649 -4. 749 -29 080 1.00 43. 04 H c

ATOM 8782 CD LYS H 151 18 899 -5. 106 -29 856 1.00 42 51 H c

ATOM 8785 CE LYS H 151 18 853 -4. 519 -31 259 1.00 43 56 H c

ATOM 8788 NZ LYS H 151 17 923 -5. 259 -32 133 1.00 44 67 H N

ATOM 8792 C LYS H 151 15 503 -5. 969 -27 139 1.00 42 33 H c

ATOM 8793 O LYS H 151 15 492 -7. 033 -26 507 1.00 43. 20 H 0

ATOM 8795 N ASP H 152 14 668 -5. 676 -28 138 1.00 42. 41 H N

ATOM 8796 CA ASP H 152 13 758 -6. 642 -28 781 1.00 42. 14 H c

ATOM 8798 CB ASP H 152 14 532 -7. 741 -29 510 1.00 40. 87 H c

ATOM 8801 CG ASP H 152 15 351 -7. 230 -30 688 1.00 43. 71 H c

ATOM 8802 ODl ASP H 152 14 901 -6. 322 -31 435 1.00 39. 56 H 0

ATOM 8803 OD2 ASP H 152 16 454 -7. 784 -30 879 1.00 43. 05 H 0

ATOM 8804 C ASP H 152 12 749 -7. 287 -27 826 1.00 41. 35 H c

ATOM 8805 O ASP H 152 12 753 -8. 485 -27 649 1.00 45 45 H 0

ATOM 8807 N TYR H 153 11 887 -6. 475 -27 226 1.00 42 13 H N

ATOM 8808 CA TYR H 153 10 839 -6. 973 -26 366 1.00 42. 23 H c

ATOM 8810 CB TYR H 153 11 161 -6. 629 -24 909 1.00 40. 02 H c

ATOM 8813 CG TYR H 153 11 066 -5. 176 -24 622 1.00 41. 06 H c

ATOM 8814 CDl TYR H 153 9 833 -4. 598 -24 254 1.00 39. 43 H c

ATOM 8816 CEl TYR H 153 9 721 -3. 244 -24 000 1.00 38. 17 H c

ATOM 8818 CZ TYR H 153 10 842 -2. 437 -24 132 1.00 39. 34 H c

ATOM 8819 OH TYR H 153 10 736 -1. 102 -23 893 1.00 38. 42 H 0

ATOM 8821 CE2 TYR H 153 12 070 -2. 977 -24 518 1.00 41. 11 H c

ATOM 8823 CD2 TYR H 153 12 174 -4. 348 -24 767 1.00 40. 86 H c

ATOM 8825 C TYR H 153 9 458 -6. 413 -26 769 1.00 45. 11 H c

ATOM 8826 O TYR H 153 9 343 -5. 359 -27 390 1.00 42 90 H 0

ATOM 8828 N PHE H 154 8 416 -7. 161 -26 422 1.00 46 57 H N

ATOM 8829 CA PHE H 154 7 059 -6. 739 -26 645 1.00 44. 01 H c

ATOM 8831 CB PHE H 154 6 580 -7. 103 -28 050 1.00 44. 53 H c

ATOM 8834 CG PHE H 154 5 293 -6. 417 -28 444 1.00 44. 85 H c

ATOM 8835 CDl PHE H 154 5 298 -5. 108 -28 903 1.00 44. 81 H c

ATOM 8837 CEl PHE H 154 4 108 -4. 452 -29 259 1.00 42. 87 H c

ATOM 8839 CZ PHE H 154 2 911 -5. 129 -29 153 1.00 44. 19 H c

ATOM 8841 CE2 PHE H 154 2 896 -6. 443 -28 691 1.00 46. 54 H c

ATOM 8843 CD2 PHE H 154 4 074 -7. 077 -28 329 1.00 47. 24 H c

ATOM 8845 C PHE H 154 6 185 -7. 395 -25 578 1.00 41. 15 H c

ATOM 8846 O PHE H 154 6 453 -8. 521 -25 175 1.00 43. 67 H 0

ATOM 8848 N PRO H 155 5 169 -6. 672 -25 071 1.00 39 86 H N

ATOM 8849 CA PRO H 155 4 829 -5. 284 -25 307 1.00 39 89 H c

ATOM 8851 CB PRO H 155 3 336 -5. 263 -24 989 1.00 38 85 H c

ATOM 8854 CG PRO H 155 3 261 -6. 165 -23 792 1.00 40 53 H c

ATOM 8857 CD PRO H 155 4 243 -7. 277 -24 101 1.00 41 11 H c

ATOM 8860 C PRO H 155 5 601 -4. 412 -24 317 1.00 40 95 H c

ATOM 8861 0 PRO H 155 6 530 -4. 884 -23 667 1.00 38 89 H 0

ATOM 8862 N GLU H 156 5 224 -3. 147 -24 206 1.00 44. 59 H N

ATOM 8863 CA GLU H 156 5 706 -2. 303 -23 110 1.00 41. 40 H c

ATOM 8865 CB GLU H 156 5 499 -0. 842 -23 490 1.00 48. 94 H c

ATOM 8868 CG GLU H 156 6 214 0. 195 -22 657 1.00 55. 98 H c

ATOM 8871 CD GLU H 156 7 643 0. 473 -23 087 1.00 52. 84 H c

ATOM 8872 OEl GLU H 156 7 790 1. 339 -23 956 1.00 53 29 H 0

ATOM 8873 OE2 GLU H 156 8 599 -0. 105 -22 516 1.00 47 55 H 0

ATOM 8874 C GLU H 156 4 896 -2. 734 -21 886 1.00 39 49 H c

ATOM 8875 0 GLU H 156 3 831 -3. 308 -22 035 1.00 41 52 H 0

ATOM 8877 N PRO H 157 5 389 -2. 491 -20 660 1.00 40 48 H N

ATOM 8878 CA PRO H 157 6 632 -1. 843 -20 264 1.00 38 35 H c

ATOM 8880 CB PRO H 157 6 186 -1. 001 -19 063 1.00 37 61 H c

ATOM 8883 CG PRO H 157 5 210 -1. 941 -18 335 1.00 36. 52 H c

ATOM 8886 CD PRO H 157 4 587 -2. 828 -19 461 1.00 37. 65 H c

ATOM 8889 C PRO H 157 7. 714 -2. 809 -19 806 1.00 38 06 H c

ATOM 8890 0 PRO H 157 7. 461 -4. 005 -19 626 1.00 40. 68 H 0 human fD_Fab

ATOM 8891 N VAL H 158 8 . ,921 -2. 260 -19. 689 1.00 38. ,70 H N

ATOM 8892 CA VAL H 158 10, ,007 -2. 834 -18. 918 1.00 42. ,29 H C

ATOM 8894 CB VAL H 158 11, ,300 -3. 148 -19. 759 1.00 41. ,19 H C

ATOM 8896 CGl VAL H 158 11.055 -4. 309 -20. 747 1.00 39. ,02 H C

ATOM 8900 CG2 VAL H 158 11. ,861 -1. 889 -20. 460 1.00 39. ,14 H c

ATOM 8904 C VAL H 158 10. ,352 -1. 802 -17. 877 1.00 44. ,51 H C

ATOM 8905 O VAL H 158 10. ,153 -0. 625 -18. 116 1.00 46. ,95 H 0

ATOM 8907 N THR H 159 10. ,802 -2. 237 -16. 706 1.00 46. ,32 H N

ATOM 8908 CA THR H 159 11. ,435 -1. 315 -15. 758 1.00 45. ,55 H C

ATOM 8910 CB THR H 159 10. ,856 -1. 384 -14. 322 1.00 44. ,23 H C

ATOM 8912 OGl THR H 159 11. ,374 -2. 531 -13. 644 1.00 43. ,43 H 0

ATOM 8914 CG2 THR H 159 9. ,352 -1. 406 -14. 349 1.00 41. 58 H C

ATOM 8918 C THR H 159 12. ,925 -1. 610 -15. 706 1.00 45. ,43 H C

ATOM 8919 O THR H 159 13. ,355 -2. 747 -15. 876 1.00 44. ,87 H 0

ATOM 8921 N VAL H 160 13. ,710 -0. 567 -15. 482 1.00 44. ,82 H N

ATOM 8922 CA VAL H 160 15. ,134 -0. 706 -15. 325 1.00 43. ,74 H c

ATOM 8924 CB VAL H 160 15. ,913 -0. 076 -16. 540 1.00 43. ,89 H c

ATOM 8926 CGl VAL H 160 17. ,390 -0. 428 -16. 503 1.00 38. ,34 H c

ATOM 8930 CG2 VAL H 160 15. ,294 -0. 483 -17. 885 1.00 42. ,75 H c

ATOM 8934 C VAL H 160 15. ,508 0. 017 -14. 036 1.00 44. ,74 H c

ATOM 8935 O VAL H 160 15. ,156 1. 170 -13. 863 1.00 47. ,18 H 0

ATOM 8937 N SER H 161 16. 163 -0. 681 -13. 111 1.00 44. ,54 H N

ATOM 8938 CA SER H 161 16. ,804 -0. 027 -11. 966 1.00 45. ,20 H c

ATOM 8940 CB SER H 161 16. ,206 -0. 499 -10. 626 1.00 43. ,42 H C

ATOM 8943 OG SER H 161 16. ,262 -1. 908 -10. 497 1.00 48. ,40 H 0

ATOM 8945 C SER H 161 18. ,288 -0. 314 -12. 016 1.00 43. ,57 H C

ATOM 8946 O SER H 161 18. ,729 -1. 165 -12. 780 1.00 45. .02 H 0

ATOM 8948 N TRP H 162 19. ,052 0. 391 -11. 186 1.00 45. ,13 H N

ATOM 8949 CA TRP H 162 20. ,488 0. 132 -11. 037 1.00 47. ,55 H c

ATOM 8951 CB TRP H 162 21. ,336 1. 336 -11. 514 1.00 43. 28 H c

ATOM 8954 CG TRP H 162 21. ,367 1. 455 -13. 016 1.00 41. 03 H c

ATOM 8955 CDl TRP H 162 20. ,460 2. 114 -13. 822 1.00 40. ,11 H c

ATOM 8957 NEl TRP H 162 20. ,807 1. 960 -15. 140 1.00 41. 72 H N

ATOM 8959 CE2 TRP H 162 21.945 1. 192 -15. 213 1.00 42. 07 H c

ATOM 8960 CD2 TRP H 162 22. ,317 0. 849 -13. 897 1.00 41. ,55 H c

ATOM 8961 CE3 TRP H 162 23. ,454 0. 054 -13. 700 1.00 41.40 H c

ATOM 8963 CZ3 TRP H 162 24. ,161 -0. 366 -14. 782 1.00 40. ,81 H c

ATOM 8965 CH2 TRP H 162 23. ,776 -0. 007 -16. 084 1.00 43. 08 H c

ATOM 8967 CZ2 TRP H 162 22. ,673 0. 768 -16. 319 1.00 42. 01 H c

ATOM 8969 C TRP H 162 20. ,815 -0. 236 -9. 593 1.00 49. ,43 H c

ATOM 8970 O TRP H 162 20. ,354 0. 425 -8. 666 1.00 51. ,30 H 0

ATOM 8972 N ASN H 163 21. ,606 -1. 292 -9. 409 1.00 52. ,91 H N

ATOM 8973 CA ASN H 163 21. ,951 -1. 789 -8. 069 1.00 54. ,41 H c

ATOM 8975 CB ASN H 163 22. ,992 -0. 874 -7. 409 1.00 55. ,25 H c

ATOM 8978 CG ASN H 163 24. ,327 -0. 902 -8. 119 1.00 55. ,62 H c

ATOM 8979 ODl ASN H 163 25. ,024 0. 109 -8. 180 1.00 51. ,67 H 0

ATOM 8980 ND2 ASN H 163 24. ,700 -2. 065 -8 . 648 1.00 56. ,38 H N

ATOM 8983 C ASN H 163 20. ,704 -1. 912 -7. 195 1.00 56. .37 H c

ATOM 8984 O ASN H 163 20. ,650 -1. 375 -6. 096 1.00 58. ,93 H 0

ATOM 8986 N SER H 164 19. ,692 -2. 577 -7. 750 1.00 59. ,97 H N

ATOM 8987 CA SER H 164 18. ,417 -2. 855 -7. 093 1.00 56. ,55 H c

ATOM 8989 CB SER H 164 18. ,620 -3. 923 -6. 027 1.00 51. .98 H c

ATOM 8992 OG SER H 164 19. ,212 -5. 060 -6. 608 1.00 46. ,71 H 0

ATOM 8994 C SER H 164 17. ,710 -1. 644 -6. 514 1.00 57. ,67 H c

ATOM 8995 O SER H 164 17. ,012 -1. 769 -5. 507 1.00 59. .77 H 0

ATOM 8997 N GLY H 165 17. ,866 -0. ,489 -7. 170 1.00 58. .76 H N

ATOM 8998 CA GLY H 165 17. ,275 0. ,782 -6. 706 1.00 56. ,36 H c

ATOM 9001 C GLY H 165 18, ,196 1. 647 -5. 849 1.00 54. .63 H c

ATOM 9002 O GLY H 165 17. ,861 2. 792 -5. 546 1.00 54. .68 H 0

ATOM 9004 N ALA H 166 19. ,346 1. 100 -5. 457 1.00 53. .47 H N

ATOM 9005 CA ALA H 166 20. ,345 1. 837 -4. 682 1.00 55. ,29 H c

ATOM 9007 CB ALA H 166 21. ,490 0. 897 -4. 284 1.00 54. .60 H c

ATOM 9011 C ALA H 166 20. ,915 3. 036 -5. 438 1.00 56. ,04 H c

ATOM 9012 O ALA H 166 21. 043 4. 117 -4. 878 1.00 57. ,31 H 0

ATOM 9014 N LEU H 167 21. 278 2. 821 -6. 703 1.00 56. ,51 H N

ATOM 9015 CA LEU H 167 21. 842 3. 864 -7. 561 1.00 52. ,29 H c

ATOM 9017 CB LEU H 167 22. ,909 3. 278 -8 . 490 1.00 53. ,38 H c

ATOM 9020 CG LEU H 167 23. ,654 4. 226 -9. 458 1.00 53. ,24 H c human fD_Fab

ATOM 9022 CDl LEU H 167 24, .351 5. ,373 -8. ,695 1.00 48, .05 H C

ATOM 9026 CD2 LEU H 167 24, .654 3, ,463 -10. ,341 1.00 48, ,18 H C

ATOM 9030 C LEU H 167 20, .743 4. ,539 -8. ,375 1.00 52, .47 H c

ATOM 9031 O LEU H 167 20 .195 3, ,960 -9. ,307 1.00 53. ,99 H 0

ATOM 9033 N THR H 168 20, .420 5. ,771 -8. ,007 1.00 53. .50 H N

ATOM 9034 CA THR H 168 19, .399 6. ,554 -8. ,692 1.00 53. ,76 H c

ATOM 9036 CB THR H 168 18, .317 6. ,980 -7. ,672 1.00 56. .47 H c

ATOM 9038 OGl THR H 168 17, .022 6. ,617 -8. ,167 1.00 60. ,03 H 0

ATOM 9040 CG2 THR H 168 18, .374 8. ,494 -7. ,355 1.00 58. ,05 H c

ATOM 9044 C THR H 168 20, ,003 7. ,791 -9. ,396 1.00 54. ,76 H c

ATOM 9045 O THR H 168 19, .522 8. 222 -10. ,448 1.00 52. ,82 H 0

ATOM 9047 N SER H 169 21, ,066 8. ,339 -8. ,809 1.00 56. ,67 H N

ATOM 9048 CA SER H 169 21, .665 9. ,591 -9. ,259 1.00 55, ,97 H c

ATOM 9050 CB SER H 169 22, ,621 10. ,104 -8. ,172 1.00 58. ,30 H c

ATOM 9053 OG SER H 169 23. .468 11.132 -8. ,644 1.00 59. ,09 H 0

ATOM 9055 C SER H 169 22. .437 9. ,436 -10. ,570 1.00 57. ,31 H c

ATOM 9056 O SER H 169 23. .321 8. ,586 -10. ,683 1.00 60. ,22 H 0

ATOM 9058 N GLY H 170 22. .118 10. ,280 -11. ,546 1.00 53. ,53 H N

ATOM 9059 CA GLY H 170 22. .802 10. ,257 -12. ,836 1.00 50. ,50 H c

ATOM 9062 C GLY H 170 22. ,194 9. ,314 -13. ,867 1.00 48. ,82 H c

ATOM 9063 O GLY H 170 22. ,663 9. ,271 -15. ,009 1.00 47. ,19 H 0

ATOM 9065 N VAL H 171 21. ,143 8. ,584 -13. ,474 1.00 49. ,42 H N

ATOM 9066 CA VAL H 171 20. ,503 7. ,593 -14. ,338 1.00 43. ,12 H c

ATOM 9068 CB VAL H 171 19. ,736 6. ,539 -13. ,517 1.00 37. ,13 H c

ATOM 9070 CGl VAL H 171 18. ,953 5. ,595 -14. ,427 1.00 36. ,43 H c

ATOM 9074 CG2 VAL H 171 20. ,698 5. ,755 -12. ,663 1.00 34. ,37 H c

ATOM 9078 C VAL H 171 19. ,569 8. ,255 -15. ,339 1.00 42. ,58 H c

ATOM 9079 0 VAL H 171 18. ,771 9. ,114 -14. ,981 1.00 42. 12 H 0

ATOM 9081 N HIS H 172 19. ,700 7. 856 -16. ,602 1.00 42. ,66 H N

ATOM 9082 CA HIS H 172 18. ,796 8. 264 -17. ,674 1.00 40. ,49 H c

ATOM 9084 CB HIS H 172 19. ,514 9. 126 -18. 723 1.00 42. ,19 H c

ATOM 9087 CG HIS H 172 20. 048 10. 412 -18. 185 1.00 44. 33 H c

ATOM 9088 NDl HIS H 172 19. 265 11. 317 -17. 502 1.00 47. ,16 H N

ATOM 9090 CEl HIS H 172 19. 996 12. 359 -17. 153 1.00 43. ,46 H c

ATOM 9092 NE2 HIS H 172 21.228 12. 158 -17. 577 1.00 48. ,54 H N

ATOM 9094 CD2 HIS H 172 21. 289 10. 943 -18. 220 1.00 45. ,85 H C

ATOM 9096 C HIS H 172 18. 343 7. 001 -18. 333 1.00 39. 00 H C

ATOM 9097 0 HIS H 172 19. 148 6. 307 -18. 962 1.00 45. 19 H 0

ATOM 9099 N THR H 173 17. 070 6. 684 -18. 178 1.00 40. ,10 H N

ATOM 9100 CA THR H 173 16. 470 5. 520 -18. 828 1.00 39. ,09 H C

ATOM 9102 CB THR H 173 15. 689 4. 676 -17. 841 1.00 35. ,21 H C

ATOM 9104 OGl THR H 173 16. 626 4. Oil -16. 986 1.00 38. 93 H 0

ATOM 9106 CG2 THR H 173 14. 834 3. 661 -18. 558 1.00 30. ,16 H C

ATOM 9110 C THR H 173 15. 583 6. 039 -19. 937 1.00 39. ,08 H C

ATOM 9111 0 THR H 173 14. 601 6. 738 -19. 692 1.00 40. ,91 H 0

ATOM 9113 N PHE H 174 15. ,959 5. 727 -21. 170 1.00 40. ,19 H N

ATOM 9114 CA PHE H 174 15. 352 6. 379 -22. 321 1.00 39. 23 H C

ATOM 9116 CB PHE H 174 16. 277 6. 320 -23. 536 1.00 36. 98 H c

ATOM 9119 CG PHE H 174 17. 543 7. 115 -23. 366 1.00 37. 32 H c

ATOM 9120 CDl PHE H 174 17. 546 8. 486 -23. 572 1.00 41. ,02 H c

ATOM 9122 CEl PHE H 174 18. ,689 9. 214 -23. 413 1.00 36. ,21 H c

ATOM 9124 CZ PHE H 174 19. 858 8. 584 -23. 044 1.00 35. 93 H c

ATOM 9126 CE2 PHE H 174 19. 874 7. 215 -22. 847 1.00 37. ,04 H c

ATOM 9128 CD2 PHE H 174 18. 728 6. 496 -22. 997 1.00 37. ,31 H c

ATOM 9130 C PHE H 174 14. 013 5. 757 -22. 643 1.00 39. ,98 H c

ATOM 9131 0 PHE H 174 13. ,828 4. 574 -22. 444 1.00 42. 53 H 0

ATOM 9133 N PRO H 175 13. 067 6. 572 -23. 139 1.00 41. ,12 H N

ATOM 9134 CA PRO H 175 11.824 6. 008 -23. 617 1.00 40. ,00 H c

ATOM 9136 CB PRO H 175 11. 083 7. 230 -24. 181 1.00 39. 62 H c

ATOM 9139 CG PRO H 175 11.625 8. 371 -23. 437 1.00 42. 28 H c

ATOM 9142 CD PRO H 175 13. 073 8. 043 -23. 273 1.00 45. 24 H c

ATOM 9145 C PRO H 175 12. 067 4. 967 -24. 708 1.00 42. 55 H c

ATOM 9146 0 PRO H 175 12. 945 5. 146 -25. 575 1.00 44. 24 H 0

ATOM 9147 N ALA H 176 11. 258 3. 914 -24. 673 1.00 41.96 H N

ATOM 9148 CA ALA H 176 11. 309 2. 854 -25. 659 1.00 41.92 H c

ATOM 9150 CB ALA H 176 10. 317 1. 779 -25. 289 1.00 42. 76 H c

ATOM 9154 C ALA H 176 10. 976 3. 377 -27. 038 1.00 43. 59 H c

ATOM 9155 0 ALA H 176 10. 102 4. 228 -27. 172 1.00 43. 47 H 0 human fD_Fab

ATOM 9157 N VAL H 177 11 661 2 851 -28. 054 1 00 45 84 H N

ATOM 9158 CA VAL H 177 11.301 3 112 -29. 440 1 00 43 47 H C

ATOM 9160 CB VAL H 177 12. 415 3 821 -30. 256 1 00 48 12 H C

ATOM 9162 CGI VAL H 177 11. 998 3 931 -31. 733 1 00 45 24 H c

ATOM 9166 CG2 VAL H 177 12. 705 5 217 -29. 678 1 00 49 52 H c

ATOM 9170 C VAL H 177 10 918 1 815 -30 137 1 00 44 50 H c

ATOM 9171 O VAL H 177 11 522 0 780 -29 920 1 00 48 47 H 0

ATOM 9173 N LEU H 178 9 907 1 897 -30 990 1 00 47 73 H N

ATOM 9174 CA LEU H 178 9 437 0 760 -31. 747 1 00 46 99 H c

ATOM 9176 CB LEU H 178 7 973 0 963 -32. 156 1 00 50 11 H c

ATOM 9179 CG LEU H 178 7. 167 -0 265 -32. 622 1 00 51.37 H c

ATOM 9181 CDl LEU H 178 7. 151 -1 406 -31.572 1 00 48 44 H c

ATOM 9185 CD2 LEU H 178 5. 735 0 154 -32. 974 1 00 49 05 H c

ATOM 9189 C LEU H 178 10. 299 0 592 -32. 985 1 00 49 30 H c

ATOM 9190 O LEU H 178 10 285 1 432 -33 877 1 00 52 49 H 0

ATOM 9192 N GLN H 179 11 050 -0 501 -33 035 1 00 49 34 H N

ATOM 9193 CA GLN H 179 11 889 -0 817 -34 164 1 00 47 35 H c

ATOM 9195 CB GLN H 179 12. 837 -1 950 -33. 786 1 00 47 18 H c

ATOM 9198 CG GLN H 179 13. 808 -1 532 -32. 707 1 00 49 69 H c

ATOM 9201 CD GLN H 179 14. 519 -2 689 -32. 093 1 00 53 67 H c

ATOM 9202 OEl GLN H 179 13. 891 -3 589 -31.531 1 00 59 36 H 0

ATOM 9203 NE2 GLN H 179 15. 845 -2 674 -32. 170 1 00 55 87 H N

ATOM 9206 C GLN H 179 11. 017 -1 229 -35. 331 1 00 46 64 H c

ATOM 9207 O GLN H 179 9. 828 -1 472 -35. 163 1. 00 48 17 H 0

ATOM 9209 N SER H 180 11 614 -1 329 -36 511 1 00 48 88 H N

ATOM 9210 CA SER H 180 10. 881 -1 727 -37 712 1 00 51 20 H c

ATOM 9212 CB SER H 180 11. 781 -1 636 -38 947 1 00 53 59 H c

ATOM 9215 OG SER H 180 12. 870 -2 527 -38. 817 1 00 57 94 H 0

ATOM 9217 C SER H 180 10. 320 -3 136 -37. 591 1 00 51.63 H c

ATOM 9218 O SER H 180 9. 391 -3 508 -38. 301 1 00 49 96 H 0

ATOM 9220 N SER H 181 10. 890 -3 914 -36. 681 1 00 53 44 H N

ATOM 9221 CA SER H 181 10. 468 -5 290 -36. 432 1 00 51 01 H c

ATOM 9223 CB SER H 181 11. 593 -6 014 -35. 697 1 00 52 96 H c

ATOM 9226 OG SER H 181 12 047 -5 237 -34 602 1 00 53 95 H 0

ATOM 9228 C SER H 181 9 185 -5 407 -35 602 1 00 52 52 H c

ATOM 9229 O SER H 181 8. 630 -6 499 -35 445 1 00 52 47 H 0

ATOM 9231 N GLY H 182 8. 707 -4 295 -35 056 1 00 52 16 H N

ATOM 9232 CA GLY H 182 7. 573 -4 344 -34 144 1 00 49 10 H c

ATOM 9235 C GLY H 182 7. 976 -4 779 -32 742 1 00 47 72 H c

ATOM 9236 O GLY H 182 7. 132 -5 197 -31. 943 1 00 50 01 H 0

ATOM 9238 N LEU H 183 9. 265 -4 687 -32. 443 1 00 45 04 H N

ATOM 9239 CA LEU H 183 9. 790 -5 012 -31. 117 1 00 47 46 H c

ATOM 9241 CB LEU H 183 10 926 -6 051 -31 195 1 00 45 78 H c

ATOM 9244 CG LEU H 183 10 637 -7 435 -31 772 1 00 45 87 H c

ATOM 9246 CDl LEU H 183 11 929 -8 234 -31 858 1 00 44 77 H c

ATOM 9250 CD2 LEU H 183 9 610 -8 160 -30 930 1 00 42 52 H c

ATOM 9254 C LEU H 183 10. 347 -3 717 -30 523 1 00 47 06 H c

ATOM 9255 O LEU H 183 10. 954 -2 923 -31.243 1 00 46 04 H 0

ATOM 9257 N TYR H 184 10. 175 -3 528 -29 221 1 00 43 71 H N

ATOM 9258 CA TYR H 184 10. 705 -2 330 -28 570 1 00 43 44 H c

ATOM 9260 CB TYR H 184 9. 903 -1 963 -27 328 1 00 45 32 H c

ATOM 9263 CG TYR H 184 8. 517 -1 462 -27 631 1 00 45 63 H c

ATOM 9264 CDl TYR H 184 8 291 -0 114 -27 932 1 00 47 91 H c

ATOM 9266 CEl TYR H 184 7 027 0 357 -28 206 1 00 46 89 H c

ATOM 9268 cz TYR H 184 5 963 -0 518 -28 168 1 00 46 18 H c

ATOM 9269 OH TYR H 184 4 696 -0 077 -28 434 1 00 45 93 H 0

ATOM 9271 CE2 TYR H 184 6 160 -1 853 -27 860 1 00 47 38 H c

ATOM 9273 CD2 TYR H 184 7. 431 -2 320 -27 597 1 00 44 51 H c

ATOM 9275 C TYR H 184 12. 169 -2 468 -28 183 1 00 40 25 H c

ATOM 9276 O TYR H 184 12. 660 -3 565 -27 907 1 00 39 41 H 0

ATOM 9278 N SER H 185 12. 855 -1 335 -28 146 1 00 39 04 H N

ATOM 9279 CA SER H 185 14 213 -1 307 -27 670 1 00 42 98 H c

ATOM 9281 CB SER H 185 15 179 -1 452 -28 863 1 00 45 82 H c

ATOM 9284 OG SER H 185 16 516 -1 399 -28 427 1 00 47 49 H 0

ATOM 9286 C SER H 185 14 476 -0 023 -26 915 1 00 41 19 H c

ATOM 9287 O SER H 185 13 913 1 021 -27 229 1 00 42 25 H 0

ATOM 9289 N LEU H 186 15 326 -0 111 -25 906 1 00 43 63 H N

ATOM 9290 CA LEU H 186 15. 695 1 050 -25 096 1 00 43 06 H c human fD_Fab

ATOM 9292 CB LEU H 186 14, .644 1, ,391 -24, .043 1.00 42, .69 H C

ATOM 9295 CG LEU H 186 14. .528 0. ,577 -22. .765 1.00 42, .26 H C

ATOM 9297 CDl LEU H 186 15, ,661 0 , ,850 -21. ,783 1.00 33, .31 H C

ATOM 9301 CD2 LEU H 186 13. .166 0. ,945 -22. .148 1.00 44, .38 H c

ATOM 9305 C LEU H 186 17, ,030 0. ,801 -24. ,442 1.00 44. .39 H c

ATOM 9306 O LEU H 186 17. .462 -0. ,346 -24, ,311 1.00 43, .04 H 0

ATOM 9308 N SER H 187 17, ,677 1. ,896 -24. ,056 1.00 46. .61 H N

ATOM 9309 CA SER H 187 18. ,906 1. ,870 -23. ,302 1.00 39. ,45 H c

ATOM 9311 CB SER H 187 20. ,036 2. ,502 -24. ,118 1. 00 43. ,73 H c

ATOM 9314 OG SER H 187 20. ,602 1. ,597 -25, ,064 1.00 42. ,54 H 0

ATOM 9316 C SER H 187 18. ,701 2. ,640 -22. ,006 1.00 37. ,79 H c

ATOM 9317 O SER H 187 17, ,951 3. ,612 -21. ,941 1.00 36. ,72 H 0

ATOM 9319 N SER H 188 19. ,339 2. ,171 -20. ,955 1.00 39. ,93 H N

ATOM 9320 CA SER H 188 19. ,397 2. ,897 -19. ,707 1.00 40. ,27 H c

ATOM 9322 CB SER H 188 18. ,879 2. ,036 -18. ,555 1.00 37. ,81 H c

ATOM 9325 OG SER H 188 18. ,694 2. ,839 -17. ,413 1.00 38. ,20 H 0

ATOM 9327 C SER H 188 20. 853 3. ,212 -19. 525 1.00 39. ,95 H c

ATOM 9328 O SER H 188 21.683 2. ,340 -19. 736 1.00 39. ,14 H 0

ATOM 9330 N VAL H 189 21. 180 4. 455 -19. 188 1.00 42. ,77 H N

ATOM 9331 CA VAL H 189 22. 586 4. ,815 -18. 908 1.00 43. ,87 H c

ATOM 9333 CB VAL H 189 23. 210 5. 709 -20. 023 1.00 43. ,83 H c

ATOM 9335 CGl VAL H 189 23. ,155 4. 992 -21. ,377 1.00 41. ,98 H c

ATOM 9339 CG2 VAL H 189 22. 514 7. 058 -20. 099 1.00 35. ,58 H c

ATOM 9343 C VAL H 189 22. 717 5. 488 -17. ,546 1.00 45. ,13 H c

ATOM 9344 O VAL H 189 21. 737 5. 980 -16. 993 1.00 46. ,37 H 0

ATOM 9346 N VAL H 190 23. 921 5. 440 -16. 999 1.00 44. ,81 H N

ATOM 9347 CA VAL H 190 24. ,267 6. 137 -15. ,773 1.00 46. ,26 H C

ATOM 9349 CB VAL H 190 24. 152 5. 226 -14. 553 1.00 43. ,18 H C

ATOM 9351 CGl VAL H 190 24. 975 3. 946 -14. 754 1.00 39. 28 H c

ATOM 9355 CG2 VAL H 190 24. 580 5. 986 -13. 300 1.00 41. ,41 H c

ATOM 9359 C VAL H 190 25. 724 6. 653 -15. 877 1.00 48. ,98 H c

ATOM 9360 O VAL H 190 26. 622 5. 940 -16. 352 1.00 46. ,58 H 0

ATOM 9362 N THR H 191 25. 939 7- 898 -15. 461 1.00 49. ,75 H N

ATOM 9363 CA THR H 191 27. 282 8. 458 -15. 341 1.00 51. ,45 H c

ATOM 9365 CB THR H 191 27. 342 9. 924 -15. 836 1.00 50. ,75 H c

ATOM 9367 OGl THR H 191 26. 065 10. 549 -15. 648 1.00 56. ,96 H 0

ATOM 9369 CG2 THR H 191 27. 674 9. 974 -17. 332 1.00 52. ,88 H c

ATOM 9373 C THR H 191 27. 740 8. 324 -13. 882 1.00 51. ,60 H c

ATOM 9374 O THR H 191 27. 030 8. 714 -12. 960 1.00 52. ,06 H 0

ATOM 9376 N VAL H 192 28. 925 7. 750 -13. 699 1.00 54. ,85 H N

ATOM 9377 CA VAL H 192 29. 520 7. 486 -12. 386 1.00 57. 62 H c

ATOM 9379 CB VAL H 192 29. 578 5. 962 -12. 131 1.00 54. ,49 H c

ATOM 9381 CGl VAL H 192 30. 349 5. 260 -13. 229 1.00 56. ,43 H c

ATOM 9385 CG2 VAL H 192 30. 226 5. 669 -10. 798 1.00 57. ,27 H c

ATOM 9389 C VAL H 192 30. 960 8. 076 -12. 318 1.00 62. 03 H c

ATOM 9390 O VAL H 192 31. 556 8. 341 -13. 354 1.00 62. ,24 H 0

ATOM 9392 N PRO H 193 31.498 8 . 351 -11. 103 1.00 66. 85 H N

ATOM 9393 CA PRO H 193 32. 956 8. 515 -10. 994 1.00 65. 53 H c

ATOM 9395 CB PRO H 193 33. 201 8 . 615 -9. 478 1.00 66. 15 H c

ATOM 9398 CG PRO H 193 31.878 8. 391 -8 . 815 1.00 66. 24 H c

ATOM 9401 CD PRO H 193 30. 826 8. 664 -9. 828 1.00 66. 54 H c

ATOM 9404 C PRO H 193 33. 776 7. 359 -11. 597 1.00 67. 53 H c

ATOM 9405 O PRO H 193 33. 376 6. 196 -11. 505 1.00 65. 84 H 0

ATOM 9406 N SER H 194 34. 915 7. 690 -12. 203 1.00 69. 86 H N

ATOM 9407 CA SER H 194 35. 774 6. 690 -12. 846 1.00 70. 78 H c

ATOM 9409 CB SER H 194 36. 784 7. 361 -13. 782 1.00 70. 20 H c

ATOM 9412 OG SER H 194 36. 152 7. 874 -14. 941 1.00 71.59 H 0

ATOM 9414 C SER H 194 36. 511 5. 828 -11. 822 1.00 71. 77 H c

ATOM 9415 O SER H 194 36. 640 4. 618 -11. 996 1.00 68. 40 H 0

ATOM 9417 N SER H 195 37. 002 6. 464 -10. 762 1.00 74. 61 H N

ATOM 9418 CA SER H 195 37. 690 5. 763 -9. 676 1.00 76. 05 H c

ATOM 9420 CB SER H 195 38. 089 6. 757 -8. 579 1.00 77. 52 H c

ATOM 9423 OG SER H 195 36. 975 7. 532 -8. 155 1.00 78. 25 H 0

ATOM 9425 C SER H 195 36. 836 4. 634 -9. 084 1.00 77. 66 H c

ATOM 9426 O SER H 195 37. 374 3. 620 -8 . 623 1.00 76. 66 H 0

ATOM 9428 N SER H 196 35. 514 4. 818 -9. 115 1.00 78. 30 H N

ATOM 9429 CA SER H 196 34. 553 3. 850 -8 . 578 1.00 78. 76 H c

ATOM 9431 CB SER H 196 33. 144 4. 438 -8. 630 1.00 83. 25 H c human fD_Fab

ATOM 9434 OG SER H 196 32. ,188 3. 464 -8. 261 1.00 86. 36 H 0

ATOM 9436 C SER H 196 34. 538 2. 498 -9. 290 1.00 78. ,25 H C

ATOM 9437 O SER H 196 34. 191 1. 485 -8. 683 1.00 77. 35 H 0

ATOM 9439 N LEU H 197 34. 899 2. 487 -10. 572 1.00 78. 82 H N

ATOM 9440 CA LEU H 197 34. 935 1. 247 -11.363 1.00 79. 00 H C

ATOM 9442 CB LEU H 197 35. 247 1. 545 -12. 835 1.00 77. 46 H C

ATOM 9445 CG LEU H 197 34. 137 2. 087 -13. 742 1.00 76. ,25 H c

ATOM 9447 CDl LEU H 197 33. 429 3. 270 -13. 133 1.00 76. ,60 H c

ATOM 9451 CD2 LEU H 197 34. 726 2. 470 -15. 102 1.00 78. 68 H c

ATOM 9455 C LEU H 197 35. 977 0. 285 -10. 795 1.00 80. ,70 H c

ATOM 9456 O LEU H 197 36. 875 0. 701 -10. 057 1.00 83. ,00 H 0

ATOM 9458 N GLY H 198 35. 844 -1. 000 -11. 115 1.00 81.01 H N

ATOM 9459 CA GLY H 198 36. ,741 -2. 028 -10. 571 1.00 82. ,81 H c

ATOM 9462 C GLY H 198 36. 483 -2. 423 -9. 116 1.00 84. 82 H c

ATOM 9463 O GLY H 198 36. 642 -3. 598 -8. 758 1.00 84. 22 H 0

ATOM 9465 N THR H 199 36. 110 -1. 448 -8. 276 1.00 84. 80 H N

ATOM 9466 CA THR H 199 35. 787 -1. 686 -6. 863 1.00 83. 33 H c

ATOM 9468 CB THR H 199 36. 358 -0. 577 -5. 975 1.00 86. ,44 H c

ATOM 9470 OGl THR H 199 37. 775 -0. 490 -6. 172 1.00 89. ,54 H 0

ATOM 9472 CG2 THR H 199 36. 052 -0. 849 -4. 495 1.00 86. 08 H c

ATOM 9476 C THR H 199 34. 274 -1. 809 -6. 625 1.00 83. ,43 H c

ATOM 9477 O THR H 199 33. 800 -2. 864 -6. 210 1.00 84. 75 H 0

ATOM 9479 N GLN H 200 33. 530 -0. 732 -6. 881 1.00 80. ,48 H N

ATOM 9480 CA GLN H 200 32. 060 -0. 749 -6. 812 1.00 77. 33 H c

ATOM 9482 CB GLN H 200 31. 512 0. 681 -6. 677 1.00 79. 01 H c

ATOM 9485 CG GLN H 200 30. 042 0. 885 -7. 059 1.00 79. 89 H c

ATOM 9488 CD GLN H 200 29. 078 0. 587 -5. 921 1.00 81.86 H c

ATOM 9489 OEl GLN H 200 28. 549 -0. 525 -5. 812 1.00 81. 90 H 0

ATOM 9490 NE2 GLN H 200 28. 838 1. 587 -5. 071 1.00 78. ,91 H N

ATOM 9493 C GLN H 200 31. 488 -1. 431 -8. 062 1.00 75. 24 H c

ATOM 9494 O GLN H 200 31. 795 -1. 027 -9. 184 1.00 74. 83 H 0

ATOM 9496 N THR H 201 30. 650 -2. 449 -7. 861 1.00 72. 53 H N

ATOM 9497 CA THR H 201 30. 041 -3. 175 -8. 977 1.00 70. ,91 H c

ATOM 9499 CB THR H 201 29. 934 -4. 693 -8. 685 1.00 74. ,12 H c

ATOM 9501 OGl THR H 201 30. 058 -5. 425 -9. 914 1.00 78. 67 H 0

ATOM 9503 CG2 THR H 201 28. 627 -5. 046 -7. 979 1.00 74. ,72 H c

ATOM 9507 C THR H 201 28. 696 -2. 540 -9. 381 1.00 69. ,53 H c

ATOM 9508 O THR H 201 27. 993 -1. 969 -8. 538 1.00 68. 84 H 0

ATOM 9510 N TYR H 202 28. 379 -2. 625 -10. 679 1.00 65. ,85 H N

ATOM 9511 CA TYR H 202 27. 205 -1. 974 -11. 290 1.00 60. ,67 H c

ATOM 9513 CB TYR H 202 27. 660 -0. 909 -12. 283 1.00 61. ,49 H C

ATOM 9516 CG TYR H 202 28. 338 0. 234 -11. 608 1.00 62. ,94 H C

ATOM 9517 CDl TYR H 202 27. 607 1. 139 -10. 851 1.00 61. ,94 H c

ATOM 9519 CEl TYR H 202 28. 226 2. 179 -10. 206 1.00 62. ,61 H c

ATOM 9521 CZ TYR H 202 29. 595 2. 325 -10. 313 1.00 61. ,00 H c

ATOM 9522 OH TYR H 202 30. 208 3. 360 -9. 671 1.00 64. ,17 H 0

ATOM 9524 CE2 TYR H 202 30. 342 1. 449 -11. 053 1.00 60. ,00 H c

ATOM 9526 CD2 TYR H 202 29. 716 0. 403 -11. 694 1.00 62. ,36 H c

ATOM 9528 C TYR H 202 26. 339 -2. 963 -12. 049 1.00 56. ,01 H c

ATOM 9529 O TYR H 202 26. 779 -3. 544 -13. 037 1.00 50. ,08 H 0

ATOM 9531 N ILE H 203 25. 100 -3. ,131 -11. 592 1.00 56. ,23 H N

ATOM 9532 CA ILE H 203 24. 170 -4. 079 -12. ,195 1.00 55. ,56 H c

ATOM 9534 CB ILE H 203 23. 821 -5. 243 -11. 247 1.00 56. ,28 H c

ATOM 9536 CGI ILE H 203 25. 095 -5. 868 -10. 663 1.00 55. ,50 H c

ATOM 9539 CDl ILE H 203 24. 865 -6. 586 -9. 358 1.00 55. ,61 H c

ATOM 9543 CG2 ILE H 203 23. 013 -6. 309 -11. 982 1.00 52. ,74 H c

ATOM 9547 C ILE H 203 22. 917 -3. 324 -12. 604 1.00 51. ,64 H c

ATOM 9548 O ILE H 203 22. 441 -2. 451 -11.885 1.00 49. ,15 H 0

ATOM 9550 N CYS H 204 22. 422 -3. 640 -13. 795 1.00 50. ,38 H N

ATOM 9551 CA CYS H 204 21.134 -3. 149 -14. 259 1.00 48. ,93 H c

ATOM 9553 CB CYS H 204 21. 231 -2. ,699 -15. ,733 1.00 48. 68 H c

ATOM 9556 SG CYS H 204 21. 530 -4. ,012 -16. 959 1.00 52. ,72 H S

ATOM 9558 C CYS H 204 20. 102 -4. ,266 -14. 052 1.00 45. ,45 H c

ATOM 9559 O CYS H 204 20. 310 -5. ,414 -14. 467 1.00 40. ,75 H 0

ATOM 9561 N ASN H 205 19. 019 -3. 925 -13. ,367 1.00 43. ,41 H N

ATOM 9562 CA ASN H 205 17. 948 -4. ,862 -13. ,078 1.00 44. ,04 H c

ATOM 9564 CB ASN H 205 17. 548 -4. 745 -11. ,618 1.00 39. ,09 H c

ATOM 9567 CG ASN H 205 18. 747 -4. 584 -10. 722 1.00 41. ,87 H c human fD_Fab

ATOM 9568 ODl ASN H 205 18 .994 -3, .502 -10. ,201 1.00 40, .79 H 0

ATOM 9569 ND2 ASN H 205 19 .548 -5, .642 -10. ,599 1.00 39, .97 H N

ATOM 9572 C ASN H 205 16, .792 -4, .556 -14. ,013 1.00 41, .64 H C

ATOM 9573 O ASN H 205 16, .123 -3, .528 -13. ,905 1.00 41. ,30 H 0

ATOM 9575 N VAL H 206 16, .579 -5. .459 -14. ,948 1.00 39, ,92 H N

ATOM 9576 CA VAL H 206 15, .583 -5, .281 -15. ,977 1.00 40, ,33 H C

ATOM 9578 CB VAL H 206 16, .212 -5. .520 -17. ,365 1.00 36, ,78 H C

ATOM 9580 CGl VAL H 206 15, .165 -5. ,404 -18. ,497 1.00 33, .62 H C

ATOM 9584 CG2 VAL H 206 17, .371 -4, ,542 -17. ,580 1.00 40, ,68 H c

ATOM 9588 C VAL H 206 14, .450 -6. ,268 -15. ,703 1.00 39, ,13 H c

ATOM 9589 O VAL H 206 14, .700 -7. ,466 -15. ,570 1.00 36, ,96 H 0

ATOM 9591 N ASN H 207 13, .228 -5. ,737 -15. ,582 1.00 40, ,08 H N

ATOM 9592 CA ASN H 207 12, .049 -6. ,532 -15. ,371 1.00 41, .51 H c

ATOM 9594 CB ASN H 207 11.435 -6, ,196 -14. ,009 1.00 41. .52 H c

ATOM 9597 CG ASN H 207 10, .395 -7. ,204 -13. ,572 1.00 40. ,87 H c

ATOM 9598 ODl ASN H 207 10, ,618 -8. ,398 -13. 626 1.00 46, ,27 H 0

ATOM 9599 ND2 ASN H 207 9, .252 -6. ,719 -13. ,144 1.00 48, ,80 H N

ATOM 9602 C ASN H 207 11.066 -6. ,291 -16. 512 1.00 43. ,64 H c

ATOM 9603 O ASN H 207 10, .805 -5. ,151 -16. 879 1.00 42, ,50 H 0

ATOM 9605 N HIS H 208 10, .558 -7. 383 -17. 084 1.00 43, ,58 H N

ATOM 9606 CA HIS H 208 9, ,588 -7. ,330 -18. 148 1.00 40. ,01 H c

ATOM 9608 CB HIS H 208 10, ,257 -7. ,710 -19. 462 1.00 36, ,58 H c

ATOM 9611 CG HIS H 208 9. ,329 -7. ,744 -20. 633 1.00 38, ,15 H c

ATOM 9612 NDl HIS H 208 8, .715 -6. ,614 -21. 136 1.00 38. ,16 H N

ATOM 9614 CEl HIS H 208 7. .974 -6. 952 -22. 176 1.00 37. ,26 H c

ATOM 9616 NE2 HIS H 208 8. ,098 -8. 252 -22. 376 1.00 36, ,08 H N

ATOM 9618 CD2 HIS H 208 8. ,929 -8. ,770 -21. 416 1.00 32. ,56 H c

ATOM 9620 C HIS H 208 8. ,479 -8. ,304 -17. 784 1.00 39, ,63 H c

ATOM 9621 O HIS H 208 8, ,565 -9. ,479 -18. 123 1.00 42, ,51 H 0

ATOM 9623 N LYS H 209 7, ,440 -7. 785 -17. 116 1.00 39. ,40 H N

ATOM 9624 CA LYS H 209 6, ,361 -8. ,577 -16. 536 1.00 42. ,78 H c

ATOM 9626 CB LYS H 209 5. ,412 -7. ,677 -15. 725 1.00 44. ,50 H c

ATOM 9629 CG LYS H 209 6. ,011 -7. ,148 -14. 461 1.00 48. ,65 H c

ATOM 9632 CD LYS H 209 5, ,077 -6. ,149 -13. 773 1.00 50. 95 H c

ATOM 9635 CE LYS H 209 5. ,577 -5. ,740 -12. 388 1.00 52. ,83 H c

ATOM 9638 NZ LYS H 209 4. ,864 -4. 517 -11.892 1.00 55. ,49 H N

ATOM 9642 C LYS H 209 5. ,547 -9. 372 -17. 548 1.00 43. 59 H c

ATOM 9643 0 LYS H 209 5. ,163 -10. 508 -17. 268 1.00 44. 62 H 0

ATOM 9645 N PRO H 210 5. ,232 -8. 767 -18. 703 1.00 43. ,11 H N

ATOM 9646 CA PRO H 210 4. ,460 -9. 512 -19. 692 1.00 44. ,51 H c

ATOM 9648 CB PRO H 210 4. ,472 -8. 591 -20. 902 1.00 47. 73 H c

ATOM 9651 CG PRO H 210 4. 584 -7. 217 -20. 303 1.00 46. ,77 H c

ATOM 9654 CD PRO H 210 5. 513 -7. 387 -19. 149 1.00 43. ,15 H c

ATOM 9657 C PRO H 210 5. 060 -10. 854 -20. 061 1.00 45. 26 H c

ATOM 9658 O PRO H 210 4. 308 -11. 791 -20.321 1.00 47. ,05 H 0

ATOM 9659 N SER H 211 6. ,386 -10. 964 -20. 067 1.00 46. 02 H N

ATOM 9660 CA SER H 211 7. 047 -12. 245 -20. 388 1.00 45. 93 H c

ATOM 9662 CB SER H 211 8. 191 -12. 008 -21. 377 1.00 42. 90 H c

ATOM 9665 OG SER H 211 9. 380 -11. 542 -20. 733 1.00 33. 39 H 0

ATOM 9667 C SER H 211 7. 587 -12. 969 -19. 160 1.00 44. 32 H c

ATOM 9668 O SER H 211 8. ,271 -13. 973 -19. 290 1.00 43. ,74 H 0

ATOM 9670 N ASN H 212 7. 292 -12. 434 -17. 980 1.00 47. 88 H N

ATOM 9671 CA ASN H 212 7. 905 -12. 870 -16. 707 1.00 49. 36 H c

ATOM 9673 CB ASN H 212 7. 342 -14. 224 -16. 264 1.00 50. 79 H c

ATOM 9676 CG ASN H 212 5. 844 -14. 265 -16. 323 1.00 52. 28 H c

ATOM 9677 ODl ASN H 212 5. ,159 -13. 496 -15. 638 1.00 47. 66 H 0

ATOM 9678 ND2 ASN H 212 5. 317 -15. 147 -17. 163 1.00 55. 13 H N

ATOM 9681 C ASN H 212 9. 418 -12. 971 -16. 746 1.00 49. 44 H c

ATOM 9682 O ASN H 212 9. 985 -13. 870 -16. 132 1.00 50. 09 H 0

ATOM 9684 N THR H 213 10. 065 -12. 057 -17. 463 1.00 50. ,19 H N

ATOM 9685 CA THR H 213 11. ,524 -12. 068 -17. 595 1.00 50. 92 H C

ATOM 9687 CB THR H 213 11. 973 -11. 913 -19. 046 1.00 47. 24 H c

ATOM 9689 OGl THR H 213 11.348 -12. 929 -19. 846 1.00 47. 32 H 0

ATOM 9691 CG2 THR H 213 13. 473 -12. 068 -19. 131 1.00 45. 56 H c

ATOM 9695 C THR H 213 12. 201 -11. 007 -16. 718 1.00 50. ,20 H c

ATOM 9696 O THR H 213 11.944 -9. 797 -16. 849 1.00 48. 21 H 0

ATOM 9698 N LYS H 214 13. 066 -11.482 -15. 820 1.00 54. 79 H N

ATOM 9699 CA LYS H 214 13. 887 -10. 606 -14. 970 1.00 54. 47 H c human fD_Fab

ATOM 9701 CB LYS H 214 13. 558 -10, ,755 -13. ,487 1.00 54. ,14 H C

ATOM 9704 CG LYS H 214 14. 215 -9. .686 -12. 617 1.00 58. ,38 H C

ATOM 9707 CD LYS H 214 14. 077 -9. ,966 -11.116 1.00 61. ,54 H c

ATOM 9710 CE LYS H 214 12. 627 -9. ,846 -10. 630 1.00 66. ,20 H c

ATOM 9713 NZ LYS H 214 12. 510 -9. ,965 -9. 124 1.00 65. ,86 H N

ATOM 9717 C LYS H 214 15. 371 -10. ,898 -15. 198 1.00 54. ,93 H c

ATOM 9718 O LYS H 214 15. 832 -12. ,019 -15. 015 1.00 55. ,62 H 0

ATOM 9720 N VAL H 215 16. 108 -9. ,873 -15. 604 1.00 54. ,51 H N

ATOM 9721 CA VAL H 215 17. 529 -9. ,995 -15. 871 1.00 52. ,81 H c

ATOM 9723 CB VAL H 215 17. 888 -9. ,630 -17. 346 1.00 47. ,64 H c

ATOM 9725 CGI VAL H 215 19. 366 -9. ,822 -17. 606 1.00 45. 37 H c

ATOM 9729 CG2 VAL H 215 17. 071 -10. ,448 -18. 336 1.00 44. ,93 H c

ATOM 9733 C VAL H 215 18. 298 -9. ,071 -14. 943 1.00 53. ,03 H c

ATOM 9734 O VAL H 215 17. 914 -7. .926 -14. 726 1.00 52. ,97 H 0

ATOM 9736 N ASP H 216 19. 375 -9. ,585 -14. 367 1.00 53. ,61 H N

ATOM 9737 CA ASP H 216 20. 311 -8. ,754 -13. 612 1.00 55. ,12 H c

ATOM 9739 CB ASP H 216 20. 410 -9. ,195 -12. 148 1.00 53. ,31 H c

ATOM 9742 CG ASP H 216 19. 064 -9. ,253 -11.474 1.00 54. ,40 H c

ATOM 9743 ODl ASP H 216 18. 418 -8. ,192 -11. 360 1.00 54. ,45 H 0

ATOM 9744 OD2 ASP H 216 18. 648 -10. ,363 -11. 072 1.00 59. ,35 H 0

ATOM 9745 C ASP H 216 21. 657 -8. ,873 -14. 311 1.00 54. 36 H c

ATOM 9746 O ASP H 216 22. 263 -9. ,941 -14. 335 1.00 55. 93 H 0

ATOM 9748 N LYS H 217 22. 118 -7. ,783 -14. 900 1.00 52. ,86 H N

ATOM 9749 CA LYS H 217 23. 320 -7. ,835 -15. 709 1.00 53. 23 H c

ATOM 9751 CB LYS H 217 23. 014 -7. ,527 -17. 171 1.00 52. ,88 H c

ATOM 9754 CG LYS H 217 24. 253 -7. ,483 -18. 065 1.00 54. ,51 H c

ATOM 9757 CD LYS H 217 23. 953 -7. ,938 -19. 477 1.00 57. ,52 H c

ATOM 9760 CE LYS H 217 24. 294 -9. ,414 -19. 678 1.00 60. ,10 H c

ATOM 9763 NZ LYS H 217 24. 012 -9. ,925 -21. 055 1.00 53. ,62 H N

ATOM 9767 C LYS H 217 24. 411 -6. ,928 -15. 153 1.00 51. ,61 H c

ATOM 9768 O LYS H 217 24. 243 -5, ,712 -15. 049 1.00 47. ,99 H 0

ATOM 9770 N LYS H 218 25. 523 -7. ,559 -14. 783 1.00 56. ,27 H N

ATOM 9771 CA LYS H 218 26. 703 -6. ,864 -14. 325 1.00 58. 26 H c

ATOM 9773 CB LYS H 218 27. 721 -7, ,860 -13. 742 1.00 61.31 H c

ATOM 9776 CG LYS H 218 27. 329 -8. ,418 -12. 364 1.00 64. ,90 H c

ATOM 9779 CD LYS H 218 28. 319 -9. ,460 -11. 792 1.00 64. ,68 H c

ATOM 9782 CE LYS H 218 27. 928 -10. ,912 -12. 122 1.00 69. 23 H c

ATOM 9785 NZ LYS H 218 28. 514 -11. ,428 -13. 423 1.00 69. ,44 H N

ATOM 9789 C LYS H 218 27. 291 -6. ,142 -15. 522 1.00 58. ,21 H c

ATOM 9790 O LYS H 218 27. 468 -6. ,740 -16. 587 1.00 58. 68 H 0

ATOM 9792 N VAL H 219 27. 551 -4. .848 -15. ,365 1.00 56. ,06 H N

ATOM 9793 CA VAL H 219 28. 163 -4, .062 -16. 435 1.00 56. ,27 H C

ATOM 9795 CB VAL H 219 27. 349 -2. ,797 -16. ,751 1.00 53. ,08 H C

ATOM 9797 CGI VAL H 219 27. 967 -2. .033 -17. 923 1.00 47, ,56 H C

ATOM 9801 CG2 VAL H 219 25. 918 -3. ,191 -17. ,052 1.00 49. ,45 H c

ATOM 9805 C VAL H 219 29. 595 -3. ,732 -16. ,042 1.00 55. ,86 H c

ATOM 9806 0 VAL H 219 29. 842 -2. ,826 -15. 252 1.00 55. ,73 H 0

ATOM 9808 N GLU H 220 30. 533 -4. ,493 -16. ,598 1.00 58. ,90 H N

ATOM 9809 CA GLU H 220 31. 946 -4. ,371 -16. ,255 1.00 62. ,62 H c

ATOM 9811 CB GLU H 220 32. 477 -5. ,739 -15. 809 1.00 62. ,94 H c

ATOM 9814 CG GLU H 220 32. 025 -6. ,148 -14. 403 1.00 67. ,00 H c

ATOM 9817 CD GLU H 220 31. 629 -7. ,618 -14. 273 1.00 68. ,23 H c

ATOM 9818 OEl GLU H 220 31. 359 -8. ,276 -15. 309 1.00 70. ,86 H 0

ATOM 9819 OE2 GLU H 220 31. 574 -8. ,112 -13. 118 1.00 69. ,06 H 0

ATOM 9820 C GLU H 220 32. 797 -3. .823 -17. ,414 1.00 62. ,91 H c

ATOM 9821 0 GLU H 220 32. 448 -4. .004 -18. ,586 1.00 60. ,46 H 0

ATOM 9823 N PRO H 221 33. 922 -3, .158 -17. ,083 1.00 63. .57 H N

ATOM 9824 CA PRO H 221 34. 861 -2. .644 -18. ,091 1.00 66. ,60 H c

ATOM 9826 CB PRO H 221 35. 911 -1, .894 -17. ,249 1.00 64. ,02 H c

ATOM 9829 CG PRO H 221 35. 805 -2, .450 -15. ,891 1.00 61. ,31 H c

ATOM 9832 CD PRO H 221 34. 379 -2. .868 -15. ,710 1.00 61.60 H c

ATOM 9835 C PRO H 221 35. 533 -3, .767 -18. 886 1.00 69. ,39 H c

ATOM 9836 0 PRO H 221 35. 711 -4. ,861 -18. ,352 1.00 69. ,87 H 0

ATOM 9837 N LYS H 222 35. 903 -3. .495 -20. ,137 1.00 73. ,22 H N

ATOM 9838 CA LYS H 222 36. 522 -4. .509 -21. ,008 1.00 74. ,12 H c

ATOM 9840 CB LYS H 222 35. 587 -4. ,848 -22. ,169 1.00 71. ,72 H c

ATOM 9843 CG LYS H 222 34. 283 -5. ,526 -21. ,709 1.00 72. ,65 H c

ATOM 9846 CD LYS H 222 34. 453 -7. .015 -21. ,398 1.00 72, .92 H c human fD_Fab

ATOM 9849 CE LYS H 222 33. .272 -7. 608 -20. ,606 1.00 72. 40 H C

ATOM 9852 NZ LYS H 222 33. .596 -7. 881 -19. ,158 1.00 70. 05 H N

ATOM 9856 C LYS H 222 37, .937 -4. 122 -21. ,494 1.00 74. 83 H C

ATOM 9857 O LYS H 222 38. .338 -2. 962 -21.393 1.00 75. ,55 H 0

ATOM 9859 N SER H 223 38, ,656 -5. 112 -22. ,039 1.00 72. 32 H N

ATOM 9860 CA SER H 223 40. .107 -5. 056 -22. 280 1.00 75. 20 H C

ATOM 9862 CB SER H 223 40, .685 -6. 467 -22. 313 1.00 73. 77 H c

ATOM 9865 OG SER H 223 40, .975 -6. 923 -21. 022 1.00 74. 25 H 0

ATOM 9867 C SER H 223 40. ,596 -4. 347 -23. ,545 1.00 80. ,84 H c

ATOM 9868 O SER H 223 41. ,116 -3. 228 -23. ,443 1.00 83. 26 H 0

ATOM 9870 N CYS H 224 40. ,499 -5. 036 -24. 699 1.00 83. 94 H N

ATOM 9871 CA CYS H 224 40. ,952 -4. 555 -26. 041 1.00 85. 60 H c

ATOM 9873 CB CYS H 224 41.338 -3. 080 -26. 037 1.00 90. 17 H c

ATOM 9876 SG CYS H 224 40. .032 -1. 982 -26. ,486 1.00 91. 75 H S

ATOM 9878 C CYS H 224 42. .122 -5. 313 -26. 691 1.00 87. 98 H c

ATOM 9879 O CYS H 224 43, .262 -5. 190 -26. 239 1.00 91. 43 H 0

ATOM 9881 OXT CYS H 224 41, .976 -5. 989 -27. ,720 1.00 82. 26 H 0

ATOM 9882 N ILE B 16 -75, .549 8. 158 -84. ,796 1.00 37. 34 B N

ATOM 9883 CA ILE B 16 -75. .602 6. 669 -84. ,844 1.00 41. 00 B c

ATOM 9885 CB ILE B 16 -77. ,028 6. 178 -85. 070 1.00 39. 70 B c

ATOM 9887 CGI ILE B 16 -77. .947 6. 671 -83. 941 1.00 40. 19 B c

ATOM 9890 CDl ILE B 16 -77. ,455 6. 377 -82. ,542 1.00 36. 48 B c

ATOM 9894 CG2 ILE B 16 -77. ,065 4. 659 -85. ,178 1.00 39. 69 B c

ATOM 9898 C ILE B 16 -74. ,712 6. 166 -85. 962 1.00 41. 64 B c

ATOM 9899 O ILE B 16 -74. ,984 6. 430 -87. 127 1.00 41.42 B 0

ATOM 9903 N LEU B 17 -73. ,655 5. 435 -85. 603 1.00 43. 95 B N

ATOM 9904 CA LEU B 17 -72. .668 4. 942 -86. ,576 1.00 43. 78 B c

ATOM 9906 CB LEU B 17 -71. ,245 5. 229 -86. ,082 1.00 45. 12 B c

ATOM 9909 CG LEU B 17 -70. ,038 4. 596 -86. ,790 1.00 46. 50 B c

ATOM 9911 CDl LEU B 17 -69. ,040 5. 655 -87. ,245 1.00 48. 07 B c

ATOM 9915 CD2 LEU B 17 -69. ,349 3. 570 -85. ,895 1.00 46. 80 B c

ATOM 9919 C LEU B 17 -72. ,908 3. 457 -86. ,854 1.00 43. 26 B c

ATOM 9920 O LEU B 17 -73. ,241 2. 697 -85. 940 1.00 40. ,13 B 0

ATOM 9922 N GLY B 18 -72. ,785 3. 064 -88. ,124 1.00 43. 20 B N

ATOM 9923 CA GLY B 18 -73. ,065 1. 691 -88. ,549 1.00 44. 81 B c

ATOM 9926 C GLY B 18 -74. ,523 1. 308 -88. ,351 1.00 46. 61 B c

ATOM 9927 O GLY B 18 -74. ,850 0. 141 -88. 122 1.00 47. 11 B 0

ATOM 9929 N GLY B 19 -75. ,399 2. 302 -88. ,424 1.00 49. 23 B N

ATOM 9930 CA GLY B 19 -76. ,828 2. 085 -88. 336 1.00 52. 43 B c

ATOM 9933 C GLY B 19 -77. .454 2. 382 -89. 682 1.00 55. 21 B c

ATOM 9934 O GLY B 19 -76. .766 2. 411 -90. ,711 1.00 52. 80 B 0

ATOM 9936 N ARG B 20 -78. .762 2. 612 -89. ,661 1.00 55. 61 B N

ATOM 9937 CA ARG B 20 -79. .516 2. 943 -90. ,859 1.00 58. 41 B c

ATOM 9939 CB ARG B 20 -80. .012 1. 664 -91.536 1.00 63. 68 B c

ATOM 9942 CG ARG B 20 -81.059 0. 892 -90. ,727 1.00 65. 31 B c

ATOM 9945 CD ARG B 20 -81. ,060 -0. 582 -91.095 1.00 67. 31 B c

ATOM 9948 NE ARG B 20 -82. ,372 -1. 205 -90. ,915 1.00 69. 03 B N

ATOM 9950 CZ ARG B 20 -82. ,742 -2. 371 -91.452 1.00 71. 67 B c

ATOM 9951 NHl ARG B 20 -81.906 -3. 076 -92. ,216 1.00 71. 24 B N

ATOM 9954 NH2 ARG B 20 -83. ,964 -2. 840 -91. ,224 1.00 71. 95 B N

ATOM 9957 C ARG B 20 -80. ,693 3. 828 -90. ,487 1.00 56. 18 B c

ATOM 9958 0 ARG B 20 -81. ,023 3. 971 -89. ,304 1.00 54. 73 B 0

ATOM 9960 N GLU B 21 -81. ,328 4. 401 -91. ,504 1.00 53. 63 B N

ATOM 9961 CA GLU B 21 -82, ,417 5. 344 -91. ,314 1.00 51. ,74 B c

ATOM 9963 CB GLU B 21 -82, .847 5. 908 -92. ,673 1.00 55. 95 B c

ATOM 9966 CG GLU B 21 -83. ,760 7. 140 -92. ,606 1.00 56. ,54 B c

ATOM 9969 CD GLU B 21 -84. .202 7. 619 -93. ,982 1.00 57. 26 B c

ATOM 9970 OEl GLU B 21 -83. ,761 7. 027 -95. ,000 1.00 55. 92 B 0

ATOM 9971 OE2 GLU B 21 -84. ,997 8. 586 -94. ,041 1.00 58. 76 B 0

ATOM 9972 C GLU B 21 -83. ,602 4. 688 -90. 612 1.00 49. 12 B c

ATOM 9973 0 GLU B 21 -83. ,997 3. 563 -90. 942 1.00 47. 99 B 0

ATOM 9975 N ALA B 22 -84, ,150 5. 400 -89. ,629 1.00 47. 34 B N

ATOM 9976 CA ALA B 22 -85. ,314 4. 933 -88. ,888 1.00 48. 37 B c

ATOM 9978 CB ALA B 22 -85. ,492 5. 766 -87. ,616 1.00 48. 29 B c

ATOM 9982 C ALA B 22 -86. ,560 5. 032 -89. ,758 1.00 50. 53 B c

ATOM 9983 0 ALA B 22 -86, .605 5. 833 -90. ,700 1.00 47. 19 B 0

ATOM 9985 N GLU B 23 -87. .565 4. 212 -89. ,450 1.00 52. ,59 B N

ATOM 9986 CA GLU B 23 -88, ,877 4. 349 -90. ,065 1.00 51. ,27 B C human fD_Fab

ATOM 9988 CB GLU B 23 -89. ,752 3. ,117 -89. 775 1. 00 54. ,81 B C

ATOM 9991 CG GLU B 23 -91. ,057 3. ,075 -90. 589 1. 00 56. ,64 B C

ATOM 9994 CD GLU B 23 -91. ,979 1. ,928 -90. 187 1. 00 58. ,75 B C

ATOM 9995 OEl GLU B 23 -91.473 0. 806 -89. 958 1. 00 59. 07 B 0

ATOM 9996 OE2 GLU B 23 -93. ,212 2. 152 -90. 111 1. 00 60. 34 B 0

ATOM 9997 C GLU B 23 -89. ,528 5. 599 -89. 488 1. 00 49. 54 B C

ATOM 9998 O GLU B 23 -89. ,700 5. 697 -88. 270 1. 00 49. 76 B 0

ATOM 10000 N ALA B 24 -89. ,900 6. ,539 -90. 361 1. 00 49. ,62 B N

ATOM 10001 CA ALA B 24 -90. ,451 7. ,826 -89. 938 1. 00 46. ,58 B C

ATOM 10003 CB ALA B 24 -91. ,029 8. ,571 -91. 121 1. 00 48. ,32 B C

ATOM 10007 C ALA B 24 -91. ,505 7. 635 -88. 853 1. 00 46. ,97 B C

ATOM 10008 O ALA B 24 -92. ,429 6. ,831 -89. 002 1. 00 50. 36 B 0

ATOM 10010 N HIS B 25 -91. ,317 8. 340 -87. 739 1. 00 49. ,89 B N

ATOM 10011 CA HI5 B 25 -92. ,310 8. ,438 -86. 655 1. 00 48. ,48 B C

ATOM 10013 CB HIS B 25 -93. ,559 9. 189 -87. 157 1. 00 52. ,90 B C

ATOM 10016 CG HIS B 25 -93. ,237 10. 434 -87. 931 1. 00 55. 68 B c

ATOM 10017 NDl HIS B 25 -93. 290 10. 496 -89. 310 1. 00 56. 69 B N

ATOM 10019 CEl HIS B 25 -92. ,937 11. 706 -89. 710 1. 00 55. 84 B c

ATOM 10021 NE2 HIS B 25 -92. ,648 12. 430 -88. 642 1. 00 56. 43 B N

ATOM 10023 CD2 HIS B 25 -92. 822 11. 656 -87. 518 1. 00 56. 72 B c

ATOM 10025 C HIS B 25 -92. ,690 7. ,096 -86. ,002 1. 00 47. ,84 B c

ATOM 10026 O HIS B 25 -93. ,665 7. ,024 -85. 257 1. 00 47. ,07 B 0

ATOM 10028 N ALA B 26 -91.896 6. ,051 -86. 248 1. 00 50. ,04 B N

ATOM 10029 CA ALA B 26 -92. 093 4. ,748 -85. 597 1. 00 49. 28 B C

ATOM 10031 CB ALA B 26 -91. ,314 3. 659 -86. 334 1. 00 49. ,81 B C

ATOM 10035 C ALA B 26 -91. 677 4. ,803 -84. 117 1. 00 49. 17 B c

ATOM 10036 O ALA B 26 -92. 022 3. 919 -83. 321 1. 00 46. ,71 B 0

ATOM 10038 N ARG B 27 -90. 922 5. 840 -83. 763 1. 00 50. 59 B N

ATOM 10039 CA ARG B 27 -90. 523 6. 083 -82. 387 1. 00 49. ,42 B c

ATOM 10041 CB ARG B 27 -88. 999 6. 045 -82. 283 1. 00 53. 55 B c

ATOM 10044 CG ARG B 27 -88. 464 4. 654 -82. 541 1. 00 53. 88 B c

ATOM 10047 CD ARG B 27 -86. 967 4. 605 -82. 670 1. 00 55. 25 B c

ATOM 10050 NE ARG B 27 -86. 563 3. 255 -83. 060 1. 00 56. 70 B N

ATOM 10052 CZ ARG B 27 -86. 253 2. ,871 -84. ,299 1. 00 58. ,45 B c

ATOM 10053 NHl ARG B 27 -86. ,289 3. ,722 -85. 322 1. 00 60. ,57 B N

ATOM 10056 NH2 ARG B 27 -85. ,901 1. ,609 -84. ,520 1. 00 58. ,55 B N

ATOM 10059 C ARG B 27 -91. 090 7. ,432 -81.975 1. 00 46. ,79 B C

ATOM 10060 O ARG B 27 -90. 395 8. ,448 -82. ,062 1. 00 46. 22 B 0

ATOM 10062 N PRO B 28 -92. ,371 7. ,447 -81.542 1. 00 47. ,35 B N

ATOM 10063 CA PRO B 28 -93. 064 8. 715 -81. 232 1. 00 47. ,41 B C

ATOM 10065 CB PRO B 28 -94. 502 8. 264 -80. 925 1. 00 49. ,25 B C

ATOM 10068 CG PRO B 28 -94. 372 6. ,827 -80. 484 1. 00 49. ,15 B c

ATOM 10071 CD PRO B 28 -93. 236 6. 269 -81.300 1. 00 48. ,76 B c

ATOM 10074 C PRO B 28 -92. 467 9. ,461 -80. 033 1. 00 47. 06 B c

ATOM 10075 O PRO B 28 -92. 647 10. ,676 -79. 898 1. 00 43. ,96 B 0

ATOM 10076 N TYR B 29 -91.753 8. ,723 -79. 184 1. 00 46. ,40 B N

ATOM 10077 CA TYR B 29 -91. ,088 9. ,282 -78. 001 1. 00 44. ,27 B c

ATOM 10079 CB TYR B 29 -90. ,760 8. ,166 -76. 997 1. 00 46. 88 B c

ATOM 10082 CG TYR B 29 -90. ,019 6. ,973 -77. 591 1. 00 48. ,48 B c

ATOM 10083 CDl TYR B 29 -88. ,663 7. ,057 -77. ,934 1. 00 49. ,49 B c

ATOM 10085 CEl TYR B 29 -87. ,989 5. ,970 -78. 484 1. 00 46. ,95 B c

ATOM 10087 CZ TYR B 29 -88. ,668 4. ,782 -78. ,687 1. 00 46. ,58 B c

ATOM 10088 OH TYR B 29 -88. ,010 3. ,704 -79. 226 1. 00 47. ,68 B 0

ATOM 10090 CE2 TYR B 29 -90. ,008 4. ,670 -78. 354 1. 00 46. ,77 B c

ATOM 10092 CD2 TYR B 29 -90. ,674 5. ,759 -77. 809 1. 00 47. ,54 B c

ATOM 10094 C TYR B 29 -89. ,814 10. ,075 -78. 300 1. 00 45. ,14 B c

ATOM 10095 O TYR B 29 -89. 290 10. ,744 -77. 413 1. 00 45. ,79 B 0

ATOM 10097 N MET B 30 -89. 330 10. ,017 -79. 538 1. 00 42. ,89 B N

ATOM 10098 CA MET B 30 -88. ,046 10. ,617 -79. .888 1. 00 43. ,21 B c

ATOM 10100 CB MET B 30 -87. ,559 10. ,049 -81. ,226 1. 00 42. ,69 B c

ATOM 10103 CG MET B 30 -86. ,117 10. ,405 -81. ,568 1. 00 43. ,55 B c

ATOM 10106 SD MET B 30 -84. ,894 9. ,565 -80. 533 1. 00 40. ,52 B S

ATOM 10107 CE MET B 30 -83. ,643 10. ,856 -80. ,480 1. 00 37. ,23 B c

ATOM 10111 C MET B 30 -88. ,103 12. ,145 -79. ,976 1. 00 44. .00 B c

ATOM 10112 0 MET B 30 -88. ,913 12. ,698 -80. ,719 1. 00 51. ,80 B 0

ATOM 10114 N ALA B 31 -87. 222 12. ,814 -79. 233 1. 00 42. ,85 B N

ATOM 10115 CA ALA B 31 -87. ,137 14. ,277 -79. ,227 1. 00 39. ,34 B c

ATOM 10117 CB ALA B 31 -87. ,389 14. ,805 -77. 833 1. 00 34. ,87 B c human fD_Fab

ATOM 10121 C ALA B 31 -85. 774 14. ,750 -79. ,718 1.00 38. ,47 B C

ATOM 10122 O ALA B 31 -84. 766 14. ,049 -79. ,556 1.00 41.02 B 0

ATOM 10124 N SER B 32 -85. 743 15. 933 -80. ,326 1.00 39. ,32 B N

ATOM 10125 CA SER B 32 -84. 485 16. 616 -80. ,617 1.00 40. ,35 B C

ATOM 10127 CB SER B 32 -84. 397 17. 060 -82. ,081 1.00 41. ,78 B C

ATOM 10130 OG SER B 32 -83. 143 17. 691 -82. ,329 1.00 44. ,67 B 0

ATOM 10132 C SER B 32 -84. 334 17. 823 -79. ,699 1.00 41. ,54 B C

ATOM 10133 O SER B 32 -85. 059 18. 815 -79. ,818 1.00 43. ,57 B 0

ATOM 10135 N VAL B 33 -83. 394 17. 741 -78. ,773 1.00 43. 38 B N

ATOM 10136 CA VAL B 33 -83. 100 18. 882 -77. ,928 1.00 43. ,16 B c

ATOM 10138 CB VAL B 33 -82. 443 18. 456 -76. ,631 1.00 38. 83 B c

ATOM 10140 CGI VAL B 33 -82. 029 19. 681 -75. ,840 1.00 40. 64 B c

ATOM 10144 CG2 VAL B 33 -83. 408 17. 584 -75. ,850 1.00 37. ,04 B c

ATOM 10148 C VAL B 33 -82. 200 19. 839 -78. ,720 1.00 44. ,86 B c

ATOM 10149 O VAL B 33 -81. 082 19. 466 -79. ,131 1.00 39. 83 B 0

ATOM 10151 N GLN B 34 -82. 701 21. 064 -78. ,928 1.00 48. 41 B N

ATOM 10152 CA GLN B 34 -82. 047 22. 050 -79. ,801 1.00 48. ,40 B C

ATOM 10154 CB GLN B 34 -83. 009 22. 484 -80. ,918 1.00 50. 36 B C

ATOM 10157 CG GLN B 34 -82. 985 21. 515 -82. ,091 1.00 52. ,82 B c

ATOM 10160 CD GLN B 34 -84. 000 21. 826 -83. 174 1.00 53. ,90 B c

ATOM 10161 OEl GLN B 34 -84. 379 22. 983 -83. ,391 1.00 58. 91 B 0

ATOM 10162 NE2 GLN B 34 -84. 432 20. 783 -83. ,884 1.00 54. 63 B N

ATOM 10165 C GLN B 34 -81. 492 23. 282 -79. ,075 1.00 45. 48 B C

ATOM 10166 O GLN B 34 -82. 034 23. 716 -78. ,056 1.00 41. 29 B 0

ATOM 10168 N LEU B 35 -80. 385 23. 804 -79. ,607 1.00 48. 46 B N

ATOM 10169 CA LEU B 35 -79. 781 25. 065 -79. 160 1.00 48. 29 B C

ATOM 10171 CB LEU B 35 -78. 368 24. 820 -78. ,616 1.00 49. ,90 B C

ATOM 10174 CG LEU B 35 -77. 504 26. 038 -78. 243 1.00 49. 38 B C

ATOM 10176 CDl LEU B 35 -77. 975 26. 665 -76. 926 1.00 48. ,13 B c

ATOM 10180 CD2 LEU B 35 -76. 025 25. 661 -78. 173 1.00 45. ,28 B c

ATOM 10184 C LEU B 35 -79. 704 26. 019 -80. 352 1.00 50. ,97 B c

ATOM 10185 O LEU B 35 -78. 909 25. 807 -81.268 1.00 49. 29 B 0

ATOM 10187 N ASN B 36 -80. 529 27. 065 -80. ,331 1.00 52. ,77 B N

ATOM 10188 CA ASN B 36 -80. 609 28. 046 -81. ,425 1.00 52. 86 B c

ATOM 10190 CB ASN B 36 -79. 304 28. 861 -81. ,535 1.00 55. ,15 B c

ATOM 10193 CG ASN B 36 -78. 935 29. 587 -80. ,231 1.00 56. ,84 B c

ATOM 10194 ODl ASN B 36 -79. 801 30. 010 -79. ,461 1.00 57. ,57 B 0

ATOM 10195 ND2 ASN B 36 -77. 640 29. 744 -79. ,996 1.00 56. 03 B N

ATOM 10198 C ASN B 36 -80. 976 27. 400 -82. ,776 1.00 53. ,97 B C

ATOM 10199 O ASN B 36 -80. 361 27. 685 -83. ,812 1.00 52. ,73 B 0

ATOM 10201 N GLY B 37 -81. 983 26. ,527 -82. ,754 1.00 54. ,32 B N

ATOM 10202 CA GLY B 37 -82. 469 25. 864 -83. .968 1.00 52. ,72 B C

ATOM 10205 C GLY B 37 -81. 535 24. ,816 -84. ,563 1.00 52. ,53 B C

ATOM 10206 O GLY B 37 -81. 720 24. 410 -85. ,707 1.00 54. ,84 B 0

ATOM 10208 N ALA B 38 -80. 545 24. ,367 -83. ,795 1.00 51. ,74 B N

ATOM 10209 CA ALA B 38 -79. 574 23. 372 -84. ,255 1.00 50. ,90 B c

ATOM 10211 CB ALA B 38 -78. 168 23. ,984 -84. ,268 1.00 50. ,03 B c

ATOM 10215 C ALA B 38 -79. 612 22. 161 -83. 325 1.00 50. ,69 B c

ATOM 10216 O ALA B 38 -79. 582 22. 319 -82. ,099 1.00 49. .28 B 0

ATOM 10218 N HIS B 39 -79. 692 20. 959 -83. ,901 1.00 47. .66 B N

ATOM 10219 CA HIS B 39 -79. 728 19. 725 -83. ,107 1.00 45. ,72 B c

ATOM 10221 CB HIS B 39 -79. 743 18. 486 -84. ,007 1.00 48. ,76 B c

ATOM 10224 CG HIS B 39 -79. 523 17. 203 -83. ,265 1.00 51. ,31 B c

ATOM 10225 NDl HIS B 39 -80. 423 16. 710 -82. ,342 1.00 52. ,79 B N

ATOM 10227 CEl HIS B 39 -79. 961 15. ,575 -81. ,845 1.00 52. .42 B c

ATOM 10229 NE2 HIS B 39 -78. 796 15. ,311 -82. ,414 1.00 51. .75 B N

ATOM 10231 CD2 HIS B 39 -78. 498 16. ,314 -83. ,304 1.00 52. .11 B C

ATOM 10233 C HIS B 39 -78. 533 19. ,660 -82. ,172 1.00 42. .52 B C

ATOM 10234 0 HIS B 39 -77. 382 19. ,735 -82. ,611 1.00 42. .94 B 0

ATOM 10236 N LEU B 40 -78. 809 19. ,527 -80. ,878 1.00 42. .05 B N

ATOM 10237 CA LEU B 40 -77. 756 19. ,422 -79. ,879 1.00 42. ,81 B C

ATOM 10239 CB LEU B 40 -78. 004 20. ,414 -78. ,747 1.00 42. .75 B c

ATOM 10242 CG LEU B 40 -76. 780 20. ,725 -77. ,890 1.00 45. ,06 B c

ATOM 10244 CDl LEU B 40 -75. 822 21. ,649 -78. ,644 1.00 46. .76 B c

ATOM 10248 CD2 LEU B 40 -77. 211 21. 337 -76. ,567 1.00 45. ,00 B c

ATOM 10252 C LEU B 40 -77. 685 18. ,007 -79. ,316 1.00 40. ,85 B c

ATOM 10253 0 LEU B 40 -76. 605 17. 397 -79. ,266 1.00 38. ,41 B 0

ATOM 10255 N CYS B 41 -78. 837 17. ,493 -78. ,885 1.00 40. .75 B N human fD_Fab

ATOM 10256 CA CYS B 41 -78, .904 16, .201 -78, .200 1.00 41 .79 B C

ATOM 10258 CB CYS B 41 -78, .809 16, .410 -76, .699 1.00 47 .25 B C

ATOM 10261 SG CYS B 41 -77, .158 16, .739 -76, .149 1.00 57 .13 B S

ATOM 10263 C CYS B 41 -80, .188 15, .462 -78, ,481 1.00 39 .20 B C

ATOM 10264 0 CYS B 41 -81.196 16, .059 -78, .878 1.00 36 .48 B 0

ATOM 10266 N GLY B 42 -80, .137 14, .152 -78, .271 1.00 37, .42 B N

ATOM 10267 CA GLY B 42 -81, .326 13, .316 -78, .292 1.00 36, .78 B c

ATOM 10270 C GLY B 42 -82, .087 13, .500 -76, ,994 1.00 36, .21 B c

ATOM 10271 0 GLY B 42 -81, .603 14, .120 -76, .050 1.00 36, .19 B 0

ATOM 10273 N GLY B 43 -83, .294 12, .961 -76, ,962 1.00 33, .76 B N

ATOM 10274 CA GLY B 43 -84, .178 13, .103 -75, .814 1.00 36, .52 B c

ATOM 10277 C GLY B 43 -85, .320 12. .117 -75. ,937 1.00 37, .04 B c

ATOM 10278 0 GLY B 43 -85, .591 11. .594 -77. ,035 1.00 33, .64 B 0

ATOM 10280 N VAL B 44 -85, .982 11. .844 -74. ,819 1.00 40, .39 B N

ATOM 10281 CA VAL B 44 -87, .075 10. ,871 -74, ,813 1.00 42, .74 B c

ATOM 10283 CB VAL B 44 -86, .616 9. ,453 -74. .304 1.00 43, .97 B c

ATOM 10285 CGI VAL B 44 -85. .746 9. ,550 -73. ,070 1.00 46, .45 B c

ATOM 10289 CG2 VAL B 44 -87. .813 8. ,557 -74. ,028 1.00 43, .73 B c

ATOM 10293 C VAL B 44 -88. .249 11. ,420 -74. ,010 1.00 43, .45 B c

ATOM 10294 0 VAL B 44 -88. .136 11.654 -72. ,801 1.00 45, .29 B 0

ATOM 10296 N LEU B 45 -89. .357 11. .668 -74, ,706 1.00 44, ,44 B N

ATOM 10297 CA LEU B 45 -90. ,601 12. ,082 -74. ,059 1.00 44, ,85 B c

ATOM 10299 CB LEU B 45 -91. ,713 12. ,333 -75. ,090 1.00 45, ,62 B c

ATOM 10302 CG LEU B 45 -92. ,981 13. ,025 -74. ,570 1.00 45, .74 B c

ATOM 10304 CDl LEU B 45 -92. ,812 14. ,537 -74. ,598 1.00 45, ,10 B c

ATOM 10308 CD2 LEU B 45 -94. ,217 12. ,623 -75. ,368 1.00 43, .32 B c

ATOM 10312 C LEU B 45 -90. ,992 10. ,950 -73. ,114 1.00 44, ,24 B c

ATOM 10313 0 LEU B 45 -91. .144 9. ,806 -73. 545 1.00 43, .68 B 0

ATOM 10315 N VAL B 46 -91. ,075 11. ,268 -71. ,824 1.00 46, .07 B N

ATOM 10316 CA VAL B 46 -91. ,443 10. ,294 -70. ,787 1.00 47. .91 B c

ATOM 10318 CB VAL B 46 -90. ,314 10. 129 -69. 707 1.00 45. .43 B c

ATOM 10320 CGI VAL B 46 -89. ,095 9. ,434 -70. ,309 1.00 40. ,42 B c

ATOM 10324 CG2 VAL B 46 -89. ,926 11.470 -69. 092 1.00 43. ,89 B c

ATOM 10328 C VAL B 46 -92. ,775 10. ,637 -70. 115 1.00 51.26 B c

ATOM 10329 0 VAL B 46 -93. ,393 9. ,783 -69. 479 1.00 50. ,88 B 0

ATOM 10331 N ALA B 47 -93. 200 11. 892 -70. 243 1.00 52. ,58 B N

ATOM 10332 CA ALA B 47 -94. ,534 12. ,319 -69. 825 1.00 52. ,29 B c

ATOM 10334 CB ALA B 47 -94. ,502 12. ,914 -68. ,407 1.00 52. ,96 B c

ATOM 10338 C ALA B 47 -95. ,073 13. 328 -70. 834 1.00 55. ,08 B c

ATOM 10339 0 ALA B 47 -94. 381 13. ,710 -71.780 1.00 53. ,02 B 0

ATOM 10341 N GLU B 48 -96. ,311 13. ,757 -70. 618 1.00 58. ,78 B N

ATOM 10342 CA GLU B 48 -97. ,014 14. 639 -71.552 1.00 57. ,45 B c

ATOM 10344 CB GLU B 48 -98. ,443 14. ,896 -71. ,054 1.00 60. ,48 B c

ATOM 10347 CG GLU B 48 -99. ,492 15. ,106 -72. 153 1.00 60. ,99 B c

ATOM 10350 CD GLU B 48 -100. 913 15. ,222 -71. 593 1.00 62. ,65 B c

ATOM 10351 OEl GLU B 48 -101. 840 15. 568 -72. 356 1.00 67. ,63 B 0

ATOM 10352 OE2 GLU B 48 -101. ,115 14. ,958 -70. 388 1.00 63. ,24 B 0

ATOM 10353 C GLU B 48 -96. ,266 15. ,960 -71. ,794 1.00 53. ,57 B c

ATOM 10354 0 GLU B 48 -96. 218 16. ,436 -72. 928 1.00 49. ,62 B 0

ATOM 10356 N GLN B 49 -95. 668 16. ,541 -70. ,754 1.00 53. ,32 B N

ATOM 10357 CA GLN B 49 -94. 899 17. ,778 -70. 937 1.00 53. ,42 B c

ATOM 10359 CB GLN B 49 -95. 657 18. 989 -70. 363 1.00 54. ,59 B c

ATOM 10362 CG GLN B 49 -95. 779 19. 089 -68. 850 1.00 56. ,37 B c

ATOM 10365 CD GLN B 49 -96. 721 20. 226 -68. 427 1.00 55. ,46 B c

ATOM 10366 OEl GLN B 49 -97. 263 20. 954 -69. 268 1.00 52. ,57 B 0

ATOM 10367 NE2 GLN B 49 -96. 909 20. 380 -67. 121 1.00 55. ,21 B N

ATOM 10370 C GLN B 49 -93. 472 17. 711 -70. 413 1.00 49. ,44 B c

ATOM 10371 0 GLN B 49 -92. 874 18. 752 -70. 150 1.00 44. ,95 B 0

ATOM 10373 N TRP B 50 -92. 923 16. 496 -70. 312 1.00 49. ,78 B N

ATOM 10374 CA TRP B 50 -91. 547 16. 268 -69. 810 1.00 49. ,37 B C

ATOM 10376 CB TRP B 50 -91. 563 15. 629 -68. 414 1.00 52. 02 B C

ATOM 10379 CG TRP B 50 -91. 925 16. 565 -67. 298 1.00 53. 16 B c

ATOM 10380 CDl TRP B 50 -93. 166 16. 751 -66. 758 1.00 52. ,93 B c

ATOM 10382 NEl TRP B 50 -93. 109 17. 685 -65. 755 1.00 53. 46 B N

ATOM 10384 CE2 TRP B 50 -91. 816 18. 124 -65. 623 1.00 54. ,14 B c

ATOM 10385 CD2 TRP B 50 -91. 039 17. 438 -66. 581 1.00 53. ,45 B c

ATOM 10386 CE3 TRP B 50 -89. 667 17. 713 -66. 658 1.00 53. 18 B c

ATOM 10388 CZ3 TRP B 50 -89. 121 18. 649 -65. 781 1.00 52. 84 B c human fD_Fab

ATOM 10390 CH2 TRP B 50 -89. 918 19. 310 -64. ,837 1.00 52. 47 B C

ATOM 10392 CZ2 TRP B 50 -91.263 19. 065 -64. ,742 1.00 53. 06 B c

ATOM 10394 C TRP B 50 -90. 724 15. 367 -70. ,736 1.00 44. 89 B c

ATOM 10395 O TRP B 50 -91. 117 14. 241 -71. 022 1.00 42. 00 B 0

ATOM 10397 N VAL B 51 -89. 562 15. 861 -71. 158 1.00 44. 99 B N

ATOM 10398 CA VAL B 51 -88. 601 15. 077 -71. 945 1.00 45. 43 B c

ATOM 10400 CB VAL B 51 -88. 218 15. 815 -73. 241 1.00 48. 19 B C

ATOM 10402 CGI VAL B 51 -86. 896 15. 268 -73. 805 1.00 49. 93 B c

ATOM 10406 CG2 VAL B 51 -89. 352 15. 710 -74. 261 1.00 47. 33 B c

ATOM 10410 C VAL B 51 -87. 330 14. 763 -71. 130 1.00 42. 56 B c

ATOM 10411 O VAL B 51 -86. 783 15. 642 -70. 475 1.00 44. 96 B 0

ATOM 10413 N LEU B 52 -86. 874 13. 510 -71. 175 1.00 40. 64 B N

ATOM 10414 CA LEU B 52 -85. 622 13. 106 -70. 512 1.00 39. 74 B C

ATOM 10416 CB LEU B 52 -85. 716 11. 676 -69. 946 1.00 40. 61 B C

ATOM 10419 CG LEU B 52 -84. 542 11. 139 -69. 105 1.00 38. 29 B C

ATOM 10421 CDl LEU B 52 -84. 124 12. 113 -68. 024 1.00 40. 09 B c

ATOM 10425 CD2 LEU B 52 -84. 880 9. 808 -68. 470 1.00 34. 66 B c

ATOM 10429 C LEU B 52 -84. 460 13. 192 -71. 494 1.00 39. 41 B c

ATOM 10430 O LEU B 52 -84. 582 12. 771 -72. 644 1.00 38. 70 B 0

ATOM 10432 N SER B 53 -83. 349 13. 758 -71. 040 1.00 38. 98 B N

ATOM 10433 CA SER B 53 -82. 136 13. 871 -71. 851 1.00 36. 98 B c

ATOM 10435 CB SER B 53 -82. 148 15. 190 -72. 643 1.00 38. 97 B c

ATOM 10438 OG SER B 53 -81.188 15. 188 -73. 693 1.00 38. 82 B 0

ATOM 10440 C SER B 53 -80. 929 13. 761 -70. 915 1.00 33. 00 B c

ATOM 10441 O SER B 53 -81. 052 13. 221 -69. 813 1.00 28. 94 B 0

ATOM 10443 N ALA B 54 -79. 775 14. 259 -71.352 1.00 36. 11 B N

ATOM 10444 CA ALA B 54 -78. 562 14. 227 -70. 552 1.00 36. 23 B c

ATOM 10446 CB ALA B 54 -77. 418 13. 636 -71. 361 1.00 38. 05 B c

ATOM 10450 C ALA B 54 -78. 207 15. 630 -70. 062 1.00 36. 56 B c

ATOM 10451 0 ALA B 54 -78. 401 16. 602 -70. 778 1.00 36. 22 B 0

ATOM 10453 N ALA B 55 -77. 666 15. 710 -68. 847 1.00 40. 47 B N

ATOM 10454 CA ALA B 55 -77. 331 16. 975 -68. 191 1.00 42. 13 B c

ATOM 10456 CB ALA B 55 -76. 909 16. 715 -66. 744 1.00 37. 66 B c

ATOM 10460 C ALA B 55 -76. 250 17. 781 -68. 915 1.00 44. 24 B c

ATOM 10461 0 ALA B 55 -76. 427 18. 967 -69. 167 1.00 47. 85 B 0

ATOM 10463 N HIS B 56 -75. 135 17. 149 -69. 265 1.00 47. 71 B N

ATOM 10464 CA HIS B 56 -74. 037 17. 880 -69. 918 1.00 52. 79 B c

ATOM 10466 CB HIS B 56 -72. 716 17. 100 -69. 862 1.00 63. 14 B c

ATOM 10469 CG HIS B 56 -72. 805 15. 713 -70. 403 1.00 69. 54 B c

ATOM 10470 NDl HIS B 56 -73. 581 15. 390 -71. 497 1.00 72. 32 B N

ATOM 10472 CEl HIS B 56 -73. 462 14. 099 -71. ,754 1.00 72. 69 B c

ATOM 10474 NE2 HIS B 56 -72. 627 13. 575 -70. 873 1.00 75. 40 B N

ATOM 10476 CD2 HIS B 56 -72. 202 14. 563 -70. ,016 1.00 73. 79 B c

ATOM 10478 C HIS B 56 -74. 345 18. 338 -71. 356 1.00 51. 53 B c

ATOM 10479 0 HIS B 56 -73. 509 18. 981 -71. 999 1.00 47. 24 B 0

ATOM 10481 N CYS B 57 -75. 535 18. 013 -71. ,856 1.00 52. 60 B N

ATOM 10482 CA CYS B 57 -76. 032 18. 602 -73. ,096 1.00 57. 47 B c

ATOM 10484 CB CYS B 57 -77. 391 18. 015 -73. ,477 1.00 57. 83 B c

ATOM 10487 SG CYS B 57 -77. 259 16. 377 -74. ,157 1.00 58. 53 B S

ATOM 10489 C CYS B 57 -76. 185 20. 108 -72. 976 1.00 59. 71 B c

ATOM 10490 0 CYS B 57 -76. 081 20. 826 -73. ,970 1.00 59. 61 B 0

ATOM 10492 N LEU B 58 -76. 456 20. 580 -71.763 1.00 63. 29 B N

ATOM 10493 CA LEU B 58 -76. 716 21. 998 -71. 539 1.00 66. 80 B C

ATOM 10495 CB LEU B 58 -77. 932 22. 164 -70. 613 1.00 67. 56 B C

ATOM 10498 CG LEU B 58 -79. 276 22. 321 -71. 345 1.00 66. 67 B c

ATOM 10500 CDl LEU B 58 -79. 515 21. 208 -72. ,360 1.00 65. 43 B c

ATOM 10504 CD2 LEU B 58 -80. 429 22. ,395 -70. ,345 1.00 67. 49 B c

ATOM 10508 C LEU B 58 -75. 503 22. ,781 -71. ,013 1.00 70. 20 B c

ATOM 10509 0 LEU B 58 -75. 606 23. ,986 -70. ,773 1.00 69. 71 B 0

ATOM 10511 N GLU B 59 -74. 351 22. ,122 -70. ,884 1.00 75. 48 B N

ATOM 10512 CA GLU B 59 -73. 207 22. ,706 -70. ,153 1.00 79. 97 B C

ATOM 10514 CB GLU B 59 -72. 061 21. ,694 -70. ,005 1.00 80. 07 B C

ATOM 10517 CG GLU B 59 -72. 004 21. ,065 -68. ,629 1.00 81. 66 B c

ATOM 10520 CD GLU B 59 -71. 054 19. ,889 -68. ,547 1.00 82. 00 B c

ATOM 10521 OEl GLU B 59 -70. 073 19. 837 -69. ,325 1.00 82. 21 B 0

ATOM 10522 OE2 GLU B 59 -71. 298 19. 012 -67. ,692 1.00 82. 80 B 0

ATOM 10523 C GLU B 59 -72. 659 24. 025 -70. ,712 1.00 84. 72 B c

ATOM 10524 0 GLU B 59 -72. 497 24. 990 -69. ,961 1.00 86. 66 B 0 human fD_Fab

ATOM 10526 N ASP B 60 -72. 361 24. 070 -72. ,008 1.00 87. ,60 B N

ATOM 10527 CA ASP B 60 -71. 862 25. 309 -72. ,630 1.00 87. 93 B C

ATOM 10529 CB ASP B 60 -70. ,439 25. 150 -73. ,216 1.00 90. 38 B C

ATOM 10532 CG ASP B 60 -70. 191 23. 788 -73. 869 1.00 91. 47 B C

ATOM 10533 ODl ASP B 60 -71. ,125 22. 962 -73. 968 1.00 92. 21 B 0

ATOM 10534 OD2 ASP B 60 -69. ,035 23. 546 -74. ,281 1.00 91. ,46 B 0

ATOM 10535 C ASP B 60 -72. ,867 25. 853 -73. 652 1.00 87. ,61 B c

ATOM 10536 O ASP B 60 -72. ,519 26. ,142 -74. ,797 1.00 86. ,75 B 0

ATOM 10538 N ALA B 61 -74. ,118 25. 998 -73. 214 1.00 88. 06 B N

ATOM 10539 CA ALA B 61 -75. ,204 26. 508 -74. 070 1.00 89. 30 B c

ATOM 10541 CB ALA B 61 -76. ,425 25. 601 -73. 977 1.00 89. ,72 B c

ATOM 10545 C ALA B 61 -75. 551 27. 929 -73. 625 1.00 91. 55 B c

ATOM 10546 O ALA B 61 -75. ,618 28. 868 -74. 430 1.00 90. 83 B 0

ATOM 10548 N ALA B 62 -75. 801 28. 007 -72. 304 1.00 93. 94 B N

ATOM 10549 CA ALA B 62 -75. 671 29. 227 -71. 471 1.00 94. 09 B c

ATOM 10551 CB ALA B 62 -74. 145 29. ,570 -71. 242 1.00 93. 99 B c

ATOM 10555 C ALA B 62 -76. ,426 30. ,448 -71. ,976 1.00 93. ,47 B c

ATOM 10556 O ALA B 62 -77. ,502 30. 768 -71. ,472 1.00 92. 48 B 0

ATOM 10558 N ASP B 63 -75. ,852 31. ,138 -72. ,954 1.00 93. ,70 B N

ATOM 10559 CA ASP B 63 -76. ,489 32. ,317 -73. ,514 1.00 93. ,17 B c

ATOM 10561 CB ASP B 63 -75. 493 33. 485 -73. ,605 1.00 93. ,55 B c

ATOM 10564 CG ASP B 63 -76. ,166 34. 846 -73. ,451 1.00 93. ,56 B c

ATOM 10565 ODl ASP B 63 -77. 141 35. 123 -74. 186 1.00 92. 99 B 0

ATOM 10566 OD2 ASP B 63 -75. 715 35. 640 -72. 594 1.00 91. 79 B 0

ATOM 10567 C ASP B 63 -77. 068 31. 914 -74. 870 1.00 93. ,18 B c

ATOM 10568 O ASP B 63 -76. 612 32. 365 -75. 924 1.00 94. 31 B 0

ATOM 10570 N GLY B 64 -78. ,068 31. 036 -74. 824 1.00 89. 93 B N

ATOM 10571 CA GLY B 64 -78. ,677 30. ,495 -76. ,035 1.00 85. 63 B c

ATOM 10574 C GLY B 64 -80. ,085 29. 972 -75. ,834 1.00 81. ,26 B c

ATOM 10575 O GLY B 64 -80. 497 29. 657 -74. ,716 1.00 81.08 B 0

ATOM 10577 N LYS B 65 -80. 807 29. 867 -76. 945 1.00 77. ,68 B N

ATOM 10578 CA LYS B 65 -82. 216 29. 478 -76. ,961 1.00 77. 23 B c

ATOM 10580 CB LYS B 65 -82. 885 30. ,073 -78. 205 1.00 76. ,65 B c

ATOM 10583 CG LYS B 65 -84. 372 29. 785 -78. ,359 1.00 77. ,19 B c

ATOM 10586 CD LYS B 65 -85. 201 31. Oil -78. ,046 1.00 76. 86 B c

ATOM 10589 CE LYS B 65 -86. 670 30. 721 -78. 172 1.00 76. ,82 B c

ATOM 10592 NZ LYS B 65 -87. 471 31. 786 -77. 514 1.00 77. 36 B N

ATOM 10596 C LYS B 65 -82. 342 27. 962 -77. 005 1.00 76. ,03 B c

ATOM 10597 0 LYS B 65 -82. ,005 27. ,346 -78. ,014 1.00 76. ,97 B 0

ATOM 10599 N VAL B 66 -82. ,838 27. ,365 -75. ,922 1.00 73. ,30 B N

ATOM 10600 CA VAL B 66 -82. ,993 25. ,912 -75. ,851 1.00 70.60 B c

ATOM 10602 CB VAL B 66 -82. ,549 25. ,354 -74. ,474 1.00 70. ,48 B c

ATOM 10604 CGI VAL B 66 -82. ,499 23. ,826 -74. ,510 1.00 69. ,36 B c

ATOM 10608 CG2 VAL B 66 -81. 188 25. 932 -74. ,068 1.00 68. ,20 B c

ATOM 10612 C VAL B 66 -84. ,442 25. 504 -76. ,133 1.00 68. ,74 B c

ATOM 10613 0 VAL B 66 -85. 364 26. 008 -75. ,500 1.00 69. ,27 B 0

ATOM 10615 N GLN B 67 -84. 619 24. ,583 -77. 083 1.00 64. ,72 B N

ATOM 10616 CA GLN B 67 -85. 940 24. ,090 -77. ,496 1.00 61. ,06 B c

ATOM 10618 CB GLN B 67 -86. 358 24. ,750 -78. 816 1.00 62. ,47 B c

ATOM 10621 CG GLN B 67 -86. 316 26. ,274 -78. ,820 1.00 62. ,64 B c

ATOM 10624 CD GLN B 67 -86. ,944 26. 853 -80. ,075 1.00 63. ,74 B c

ATOM 10625 OEl GLN B 67 -86. ,310 26. .912 -81. ,137 1.00 63, ,70 B 0

ATOM 10626 NE2 GLN B 67 -88. ,206 27. ,279 -79. ,961 1.00 65. ,31 B N

ATOM 10629 C GLN B 67 -85. ,948 22. ,569 -77. 691 1.00 57, ,56 B c

ATOM 10630 0 GLN B 67 -84. ,899 21. ,961 -77. 932 1.00 55. ,58 B 0

ATOM 10632 N VAL B 68 -87. ,134 21.963 -77. 597 1.00 54. ,63 B N

ATOM 10633 CA VAL B 68 -87. ,313 20. ,523 -77. 855 1.00 51. ,29 B c

ATOM 10635 CB VAL B 68 -87. 897 19. ,779 -76. ,620 1.00 50. ,83 B c

ATOM 10637 CGI VAL B 68 -88. ,257 18. ,335 -76. 978 1.00 50. ,08 B c

ATOM 10641 CG2 VAL B 68 . -86. ,924 19. ,832 -75. 443 1.00 45. ,22 B c

ATOM 10645 C VAL B 68 -88. 263 20. ,313 -79. ,024 1.00 48. ,09 B c

ATOM 10646 0 VAL B 68 -89. ,373 20. ,821 -79. ,009 1.00 47. .07 B 0

ATOM 10648 N LEU B 69 -87. ,826 19. ,549 -80. ,018 1.00 45. ,01 B N

ATOM 10649 CA LEU B 69 -88. ,612 19. ,302 -81. ,228 1.00 44. ,58 B c

ATOM 10651 CB LEU B 69 -87. ,730 19. ,529 -82. ,464 1.00 46. ,79 B c

ATOM 10654 CG LEU B 69 -88. ,305 19. ,230 -83. ,846 1.00 44. ,96 B c

ATOM 10656 CDl LEU B 69 -89. ,453 20. ,182 -84. ,153 1.00 45. ,17 B c

ATOM 10660 CD2 LEU B 69 -87. ,197 19. ,339 -84. ,891 1.00 45. ,01 B c human fD_Fab

ATOM 10664 C LEU B 69 -89, .189 17, .877 -81. .238 1.00 44, .66 B C

ATOM 10665 0 LEU B 69 -88, .447 16. ,887 -81, ,370 1.00 41, .12 B 0

ATOM 10667 N LEU B 70 -90, .511 17. .785 -81. ,122 1.00 44, ,63 B N

ATOM 10668 CA LEU B 70 -91, .223 16. .500 -81.126 1.00 44, ,29 B C

ATOM 10670 CB LEU B 70 -92, .319 16. .509 -80. ,053 1.00 45, ,97 B C

ATOM 10673 CG LEU B 70 -91, .874 16. ,094 -78. ,647 1.00 46, .22 B C

ATOM 10675 CDl LEU B 70 -92, .427 17. ,037 -77. ,576 1.00 43, ,62 B c

ATOM 10679 CD 2 LEU B 70 -92, .269 14. ,636 -78. ,373 1.00 45, .99 B c

ATOM 10683 C LEU B 70 -91, .839 16. ,157 -82. ,494 1.00 44, ,84 B c

ATOM 10684 0 LEU B 70 -91.997 17, ,032 -83. ,358 1.00 44, ,19 B 0

ATOM 10686 N GLY B 71 -92, .170 14. ,873 -82. ,671 1.00 45, .19 B N

ATOM 10687 CA GLY B 71 -92, ,788 14. ,351 -83. ,892 1.00 43. .99 B c

ATOM 10690 C GLY B 71 -91, .944 14. ,459 -85. ,151 1.00 47, .61 B c

ATOM 10691 0 GLY B 71 -92, .466 14. ,357 -86. ,266 1.00 52. .66 B 0

ATOM 10693 N ALA B 72 -90. .640 14. ,657 -84. ,994 1.00 48. ,99 B N

ATOM 10694 CA ALA B 72 -89. .775 14. ,884 -86. ,150 1.00 45. ,51 B c

ATOM 10696 CB ALA B 72 -88. ,653 15. ,884 -85. ,817 1.00 42. ,58 B c

ATOM 10700 C ALA B 72 -89. ,197 13. ,583 -86. ,685 1.00 43, ,65 B c

ATOM 10701 0 ALA B 72 -89. ,023 12. ,598 -85. ,956 1.00 43. ,64 B 0

ATOM 10703 N HIS B 73 -88. ,935 13. 582 -87. 982 1.00 42, ,84 B N

ATOM 10704 CA HIS B 73 -88. ,101 12. ,565 -88. ,601 1.00 44. ,68 B c

ATOM 10706 CB HIS B 73 -88. ,895 11. ,735 -89. ,610 1.00 47, ,97 B c

ATOM 10709 CG HIS B 73 -88, ,151 10. ,540 -90. ,115 1.00 50. ,40 B c

ATOM 10710 NDl HIS B 73 -87. ,449 9. ,701 -89. ,279 1.00 52. ,16 B N

ATOM 10712 CEl HIS B 73 -86. .890 8. ,740 -89. 992 1.00 51. ,61 B c

ATOM 10714 NE2 HIS B 73 -87. ,209 8. ,920 -91. ,260 1.00 52, ,75 B N

ATOM 10716 CD 2 HIS B 73 -88. ,003 10. ,037 -91. ,364 1.00 54. ,54 B C

ATOM 10718 C HIS B 73 -86. ,922 13. ,281 -89. 262 1.00 44. ,82 B c

ATOM 10719 0 HIS B 73 -85. 760 13. ,001 -88. 944 1.00 41. ,94 B 0

ATOM 10721 N SER B 74 -87. 232 14. 213 -90. 165 1.00 44. ,47 B N

ATOM 10722 CA SER B 74 -86. 231 15. 093 -90. 773 1.00 43. ,35 B c

ATOM 10724 CB SER B 74 -86. 654 15. 478 -92. 199 1.00 47. ,59 B c

ATOM 10727 OG SER B 74 -85. 695 16. 321 -92. 824 1.00 49. ,46 B 0

ATOM 10729 C SER B 74 -86. 083 16. 354 -89. 926 1.00 43. ,36 B c

ATOM 10730 0 SER B 74 -87. ,073 16. 904 -89. ,446 1.00 43. ,42 B 0

ATOM 10732 N LEU B 75 -84. 848 16. 814 -89. 745 1.00 44. ,98 B N

ATOM 10733 CA LEU B 75 -84. 594 18. 047 -88. 993 1.00 45. 22 B c

ATOM 10735 CB LEU B 75 -83. 130 18. 126 -88. 549 1.00 47. ,78 B c

ATOM 10738 CG LEU B 75 -82. 804 17. 495 -87. 194 1.00 46. ,82 B c

ATOM 10740 CDl LEU B 75 -81. 301 17. 323 -87. 040 1.00 46. ,65 B c

ATOM 10744 CD2 LEU B 75 -83. 381 18. 338 -86. 075 1.00 46. ,00 B c

ATOM 10748 C LEU B 75 -84. 953 19. 312 -89. 779 1.00 46. ,72 B c

ATOM 10749 0 LEU B 75 -85. 489 20. 263 -89. 206 1.00 47. ,71 B 0

ATOM 10751 N SER B 76 -84. 659 19. ,317 -91. 081 1.00 47. ,72 B N

ATOM 10752 CA SER B 76 -84. 805 20. 515 -91. 923 1.00 47. ,68 B c

ATOM 10754 CB SER B 76 -83. 716 20. 545 -92. 998 1.00 49. ,41 B c

ATOM 10757 OG SER B 76 -83. 799 19. 401 -93. 832 1.00 50. ,45 B 0

ATOM 10759 C SER B 76 -86. 168 20. 602 -92. 604 1.00 49. ,40 B c

ATOM 10760 0 SER B 76 -86. 724 21. 696 -92. 770 1.00 45. 92 B 0

ATOM 10762 N GLN B 77 -86. 705 19. 451 -93. 006 1.00 52. ,99 B N

ATOM 10763 CA GLN B 77 -87. 902 19. 430 -93. 852 1.00 53. ,19 B c

ATOM 10765 CB GLN B 77 -87. 980 18. 145 -94. 692 1.00 57. ,76 B c

ATOM 10768 CG GLN B 77 -87. 907 18. 370 -96. 202 1.00 61. ,99 B c

ATOM 10771 CD GLN B 77 -86. 522 18. 768 -96. 685 1.00 64. ,19 B c

ATOM 10772 OEl GLN B 77 -86. 060 18. 279 -97. 713 1.00 65. ,90 B 0

ATOM 10773 NE2 GLN B 77 -85. 854 19. 657 -95. 950 1.00 63. ,59 B N

ATOM 10776 C GLN B 77 -89. 173 19. 582 -93. 028 1.00 53. ,90 B c

ATOM 10777 0 GLN B 77 -89. 234 19. 111 -91. 887 1.00 50. ,34 B 0

ATOM 10779 N PRO B 78 -90. 198 20. 242 -93. 610 1.00 56. ,71 B N

ATOM 10780 CA PRO B 78 -91.476 20. 345 -92. 918 1.00 56. ,73 B C

ATOM 10782 CB PRO B 78 -92. 244 21.397 -93. 733 1.00 59. ,59 B C

ATOM 10785 CG PRO B 78 -91. 652 21. 336 -95. 104 1.00 59. ,70 B C

ATOM 10788 CD PRO B 78 -90. 217 20. 920 -94. 926 1.00 58. ,18 B C

ATOM 10791 C PRO B 78 -92. 230 19. 017 -92. 909 1.00 55. 23 B c

ATOM 10792 0 PRO B 78 -92. 250 18. 295 -93. 912 1.00 50. ,24 B 0

ATOM 10793 N GLU B 79 -92. 829 18. 712 -91. 760 1.00 55. 38 B N

ATOM 10794 CA GLU B 79 -93. 652 17. 520 -91. 575 1.00 55. ,00 B c

ATOM 10796 CB GLU B 79 -92. 838 16. 426 -90. 890 1.00 57. ,94 B c human fD_Fab

ATOM 10799 CG GLU B 79 -91, .471 16, .189 -91.511 1.00 58, .05 B C

ATOM 10802 CD GLU B 79 -90, .740 15, ,021 -90, .881 1.00 59, .64 B C

ATOM 10803 OEl GLU B 79 -91, .110 14. .624 -89, .746 1.00 59, .59 B 0

ATOM 10804 OE2 GLU B 79 -89, .788 14. ,516 -91, .525 1.00 59, .88 B 0

ATOM 10805 C GLU B 79 -94, .858 17. .905 -90, .711 1.00 56, .30 B C

ATOM 10806 O GLU B 79 -94, .756 18. .820 -89, .883 1.00 55. .14 B 0

ATOM 10808 N PRO B 80 -95, .999 17. ,207 -90, ,886 1.00 56. ,51 B N

ATOM 10809 CA PRO B 80 -97, .227 17. ,616 -90, .180 1.00 55. .47 B C

ATOM 10811 CB PRO B 80 -98, .321 16. ,729 -90, ,799 1.00 55. ,76 B C

ATOM 10814 CG PRO B 80 -97, ,618 15. ,578 -91, .411 1.00 56. ,15 B C

ATOM 10817 CD PRO B 80 -96, .197 15. ,995 -91.705 1.00 57. ,02 B c

ATOM 10820 C PRO B 80 -97, ,129 17. ,417 -88, ,662 1.00 54. ,97 B c

ATOM 10821 O PRO B 80 -97, .624 18. ,251 -87, .903 1.00 53. ,17 B 0

ATOM 10822 N SER B 81 -96, .483 16. ,330 -88, ,239 1.00 55. ,10 B N

ATOM 10823 CA SER B 81 -96, ,278 16. ,027 -86, ,806 1.00 52. ,08 B c

ATOM 10825 CB SER B 81 -95. ,875 14. ,555 -86, ,619 1.00 52. ,18 B c

ATOM 10828 OG SER B 81 -95. ,329 14. ,015 -87. ,823 1.00 52. ,84 B 0

ATOM 10830 C SER B 81 -95. .242 16. ,938 -86. ,131 1.00 50. ,19 B c

ATOM 10831 O SER B 81 -95. ,315 17. ,189 -84. .925 1.00 47. ,91 B 0

ATOM 10833 N LYS B 82 -94. ,296 17. ,430 -86. ,930 1.00 48. ,85 B N

ATOM 10834 CA LYS B 82 -93. ,168 18. ,238 -86. .461 1.00 48. ,69 B c

ATOM 10836 CB LYS B 82 -92. ,269 18. ,614 -87. ,666 1.00 49. ,45 B c

ATOM 10839 CG LYS B 82 -90. ,777 18. ,351 -87. ,472 1.00 48. ,84 B c

ATOM 10842 CD LYS B 82 -89. ,951 18. ,678 -88. ,731 1.00 48. ,36 B c

ATOM 10845 CE LYS B 82 -89, ,259 20. 053 -88. ,636 1.00 49. 09 B c

ATOM 10848 NZ LYS B 82 -88. ,200 20. ,270 -89. ,680 1.00 47. ,71 B N

ATOM 10852 C LYS B 82 -93. ,612 19. 515 -85. ,748 1.00 50. 32 B c

ATOM 10853 O LYS B 82 -94. 167 20. ,413 -86. ,378 1.00 56. ,26 B 0

ATOM 10855 N ARG B 83 -93. 367 19. 593 -84. ,443 1.00 51. 92 B N

ATOM 10856 CA ARG B 83 -93. ,568 20. ,837 -83. ,701 1.00 51.51 B c

ATOM 10858 CB ARG B 83 -94. 888 20. 809 -82. ,929 1.00 55. 50 B c

ATOM 10861 CG ARG B 83 -95. 176 22. 130 -82. ,226 1.00 56. 36 B c

ATOM 10864 CD ARG B 83 -96. 571 22. 221 -81. ,634 1.00 56. 39 B c

ATOM 10867 NE ARG B 83 -96. 568 23. 192 -80. ,541 1.00 58. 22 B N

ATOM 10869 CZ ARG B 83 -97. ,559 23. 378 -79. ,671 1.00 59. 21 B c

ATOM 10870 NHl ARG B 83 -98. 685 22. 666 -79. ,749 1.00 57. 85 B N

ATOM 10873 NH2 ARG B 83 -97. 416 24. 291 -78. ,710 1.00 58. 24 B N

ATOM 10876 C ARG B 83 -92. 389 21. 148 -82. ,766 1.00 50. 83 B C

ATOM 10877 O ARG B 83 -91. 919 20. 274 -82. 028 1.00 47. 03 B 0

ATOM 10879 N LEU B 84 -91. 925 22. 399 -82. ,825 1.00 50. 29 B N

ATOM 10880 CA LEU B 84 -90. 818 22. 907 -82. 004 1.00 51.40 B c

ATOM 10882 CB LEU B 84 -90. 004 23. 917 -82. 834 1.00 52. 15 B c

ATOM 10885 CG LEU B 84 -88. 729 24. 584 -82. 294 1.00 51. 96 B c

ATOM 10887 CDl LEU B 84 -87. 567 23. 596 -82. 161 1.00 48. 49 B c

ATOM 10891 CD2 LEU B 84 -88. 342 25. 746 -83. ,220 1.00 51.60 B c

ATOM 10895 C LEU B 84 -91.380 23. 573 -80. 743 1.00 52. 61 B c

ATOM 10896 O LEU B 84 -92. 144 24. 534 -80. 843 1.00 52. 90 B 0

ATOM 10898 N TYR B 85 -91.008 23. 060 -79. 568 1.00 52. 62 B N

ATOM 10899 CA TYR B 85 -91. 532 23. 559 -78. 280 1.00 53. 35 B c

ATOM 10901 CB TYR B 85 -92. 008 22. 405 -77. 389 1.00 52. 50 B c

ATOM 10904 CG TYR B 85 -93. 171 21.602 -77. 927 1.00 51. 32 B c

ATOM 10905 CDl TYR B 85 -94. 395 21. 580 -77. 261 1.00 52. 24 B c

ATOM 10907 CEl TYR B 85 -95. 462 20. 831 -77. 740 1.00 52. 75 B c

ATOM 10909 CZ TYR B 85 -95. 309 20. 095 -78. 903 1.00 53. 14 B c

ATOM 10910 OH TYR B 85 -96. 361 19. 354 -79. 401 1.00 52. 53 B 0

ATOM 10912 CE2 TYR B 85 -94. 100 20. 101 -79. 575 1.00 52. 39 B c

ATOM 10914 CD2 TYR B 85 -93. 042 20. 849 -79. 085 1.00 50. 34 B c

ATOM 10916 C TYR B 85 -90. 465 24. 326 -77. 515 1.00 55. 13 B c

ATOM 10917 0 TYR B 85 -89. 303 23. 910 -77. 481 1.00 57. 61 B 0

ATOM 10919 N ASP B 86 -90. 861 25. 428 -76. ,884 1.00 57. 16 B N

ATOM 10920 CA ASP B 86 -89. 970 26. 145 -75. 965 1.00 58. 44 B c

ATOM 10922 CB ASP B 86 -90. 426 27. 594 -75. 766 1.00 63. 08 B c

ATOM 10925 CG ASP B 86 -89. 868 28. 522 -76. 823 1.00 65. 70 B c

ATOM 10926 ODl ASP B 86 -90. 413 28. 557 -77. 952 1.00 63. 76 B 0

ATOM 10927 OD2 ASP B 86 -88. 867 29. 208 -76. ,512 1.00 67. 49 B 0

ATOM 10928 C ASP B 86 -89. 907 25. 417 -74. 623 1.00 56. 72 B c

ATOM 10929 0 ASP B 86 -90. 754 24. 561 -74. 331 1.00 52. 66 B 0

ATOM 10931 N VAL B 87 -88. 899 25. 751 -73. 821 1.00 54. 97 B N human fD_Fab

ATOM 10932 CA VAL B 87 -88 .651 25. .049 -72, .565 1. ,00 58, .25 B C

ATOM 10934 CB VAL B 87 -87, .177 24. ,529 -72, .492 1. ,00 57, .28 B C

ATOM 10936 CGI VAL B 87 -86, .849 24. .004 -71, .105 1. ,00 56, .39 B C

ATOM 10940 CG2 VAL B 87 -86, .936 23. ,444 -73, ,541 1. ,00 55, .90 B C

ATOM 10944 C VAL B 87 -88, .967 25. .942 -71, .365 1. ,00 59, .58 B C

ATOM 10945 O VAL B 87 -88, .310 26. .967 -71, .151 1. ,00 58, .95 B 0

ATOM 10947 N LEU B 88 -89, .966 25. ,532 -70, .584 1. ,00 61.74 B N

ATOM 10948 CA LEU B 88 -90, .378 26. ,268 -69, .385 1. ,00 61, .68 B c

ATOM 10950 CB LEU B 88 -91, .826 25. ,922 -69, ,009 1. ,00 63, .99 B c

ATOM 10953 CG LEU B 88 -92, .401 26. ,568 -67, .739 1. ,00 64. .77 B c

ATOM 10955 CDl LEU B 88 -92, .224 28. ,091 -67, .765 1. ,00 64. ,30 B c

ATOM 10959 CD2 LEU B 88 -93, .873 26. ,178 -67. .542 1. ,00 63. .20 B c

ATOM 10963 C LEU B 88 -89, .458 26. ,024 -68. ,186 1. ,00 61.02 B c

ATOM 10964 0 LEU B 88 -89, .323 26. ,901 -67. .331 1. ,00 60. ,87 B 0

ATOM 10966 N ARG B 89 -88, .838 24. ,842 -68. .117 1. ,00 62. ,37 B N

ATOM 10967 CA ARG B 89 -87, .984 24. ,481 -66. .973 1. ,00 61.62 B c

ATOM 10969 CB ARG B 89 -88, .855 23. 958 -65. .823 1. ,00 63. ,06 B c

ATOM 10972 CG ARG B 89 -88, .522 24. ,554 -64. ,462 1. 00 65. ,03 B c

ATOM 10975 CD ARG B 89 -89. ,480 24. ,048 -63. ,379 1. 00 65. ,42 B c

ATOM 10978 NE ARG B 89 -88. .859 23. ,058 -62. ,491 1. 00 65. ,61 B N

ATOM 10980 CZ ARG B 89 -89. .520 22. ,128 -61. ,799 1. 00 65. ,03 B c

ATOM 10981 NHl ARG B 89 -90. .843 22. 019 -61. ,881 1. 00 64. ,97 B N

ATOM 10984 NH2 ARG B 89 -88. ,849 21.286 -61. ,021 1. 00 65. ,29 B N

ATOM 10987 C ARG B 89 -86. ,949 23. 416 -67. ,333 1. 00 58. ,80 B c

ATOM 10988 0 ARG B 89 -87. ,290 22. ,417 -67. ,964 1. 00 56. ,55 B 0

ATOM 10990 N ALA B 90 -85. ,698 23. 627 -66. ,918 1. 00 57. ,48 B N

ATOM 10991 CA ALA B 90 -84. ,624 22. 625 -67. ,080 1. 00 55. ,53 B C

ATOM 10993 CB ALA B 90 -83. ,466 23. 213 -67. ,869 1. 00 58. ,54 B C

ATOM 10997 C ALA B 90 -84. ,124 22. 101 -65. ,730 1. 00 52. ,58 B c

ATOM 10998 0 ALA B 90 -83. ,453 22. 822 -64. ,986 1. 00 49. ,36 B 0

ATOM 11000 N VAL B 91 -84. ,439 20. 842 -65. ,427 1. 00 52. ,61 B N

ATOM 11001 CA VAL B 91 -84. ,057 20. ,227 -64. ,148 1. 00 51. ,47 B c

ATOM 11003 CB VAL B 91 -85. ,271 19. 607 -63. ,419 1. 00 50. ,48 B c

ATOM 11005 CGI VAL B 91 -84. ,842 19. 050 -62. ,050 1. 00 49. ,03 B c

ATOM 11009 CG2 VAL B 91 -86. ,365 20. 639 -63. ,245 1. 00 52. ,98 B c

ATOM 11013 C VAL B 91 -82. ,984 19. 133 -64. ,302 1. 00 48. ,93 B c

ATOM 11014 0 VAL B 91 -83. ,315 17. 953 -64. ,446 1. 00 48. ,49 B 0

ATOM 11016 N PRO B 92 -81. ,690 19. 512 -64. ,277 1. 00 47. ,45 B N

ATOM 11017 CA PRO B 92 -80. ,677 18. 459 -64. ,201 1. 00 48. ,88 B c

ATOM 11019 CB PRO B 92 -79. ,348 19. 220 -64. ,349 1. 00 49. ,37 B c

ATOM 11022 CG PRO B 92 -79. ,649 20. 605 -63. ,938 1. 00 50. ,41 B c

ATOM 11025 CD PRO B 92 -81. ,078 20. 853 -64. ,349 1. 00 50. ,15 B c

ATOM 11028 C PRO B 92 -80. ,702 17. 718 -62. ,874 1. 00 50. ,45 B c

ATOM 11029 0 PRO B 92 -81.141 18. 270 -61. ,862 1. 00 53. ,12 B 0

ATOM 11030 N HIS B 93 -80. 225 16. 475 -62. ,881 1. 00 48. 33 B N

ATOM 11031 CA HIS B 93 -80. ,074 15. 713 -61. ,640 1. 00 47. ,34 B c

ATOM 11033 CB HIS B 93 -79. ,428 14. 343 -61. ,909 1. 00 42. ,80 B c

ATOM 11036 CG HIS B 93 -79. ,419 13. 425 -60. ,719 1. 00 42. ,60 B c

ATOM 11037 NDl HIS B 93 -78. ,470 13. 503 -59. ,720 1. 00 38. ,99 B N

ATOM 11039 CEl HIS B 93 -78. ,713 12. 575 -58. ,810 1. 00 38. 06 B c

ATOM 11041 NE2 HIS B 93 -79. ,784 11. 896 -59. ,179 1. 00 34. 18 B N

ATOM 11043 CD2 HIS B 93 -80. ,241 12. 404 -60. 373 1. 00 38. 75 B C

ATOM 11045 C HIS B 93 -79. ,218 16. 551 -60. ,684 1. 00 47. 62 B C

ATOM 11046 0 HIS B 93 -78. ,200 17. 095 -61. ,105 1. 00 45. 35 B 0

ATOM 11048 N PRO B 94 -79. ,640 16. 676 -59. ,404 1. 00 51.76 B N

ATOM 11049 CA PRO B 94 -78. ,928 17. 561 -58. ,467 1. 00 51. 47 B c

ATOM 11051 CB PRO B 94 -79. 632 17. 306 -57. ,120 1. 00 52. 26 B c

ATOM 11054 CG PRO B 94 -80. 406 16. 050 -57. ,297 1. 00 54. 13 B c

ATOM 11057 CD PRO B 94 -80. 784 16. 018 -58. ,748 1. 00 52. 39 B c

ATOM 11060 C PRO B 94 -77. 435 17. 259 -58. ,344 1. 00 51.09 B c

ATOM 11061 0 PRO B 94 -76. 629 18. 185 -58. 198 1. 00 52. 18 B 0

ATOM 11062 N ASP B 95 -77. 082 15. 974 -58. ,407 1. 00 48. 72 B N

ATOM 11063 CA ASP B 95 -75. 693 15. 525 -58. 231 1. 00 50. 35 B c

ATOM 11065 CB ASP B 95 -75. 650 14. 126 -57. 606 1. 00 48. 55 B c

ATOM 11068 CG ASP B 95 -76. 159 14. 112 -56. 193 1. 00 50. 54 B c

ATOM 11069 ODl ASP B 95 -75. 421 14. 597 -55. 312 1. 00 51.54 B 0

ATOM 11070 OD2 ASP B 95 -77. 291 13. 628 -55. 962 1. 00 51. 71 B 0

ATOM 11071 C ASP B 95 -74. 890 15. 482 -59. 533 1. 00 50. 98 B c human fD_Fab

ATOM 11072 O ASP B 95 -73. ,707 15. 118 -59. ,528 1. 00 50. ,32 B 0

ATOM 11074 N SER B 96 -75. 519 15. 835 -60. ,652 1. 00 50. ,35 B N

ATOM 11075 CA SER B 96 -74. ,784 15. 901 -61.922 1. 00 53. ,75 B C

ATOM 11077 CB SER B 96 -75. ,725 15. 935 -63. ,139 1. 00 52. ,88 B C

ATOM 11080 OG SER B 96 -76. ,268 17. 220 -63. ,372 1. 00 54. ,36 B 0

ATOM 11082 C SER B 96 -73. 853 17. 109 -61. ,930 1. 00 55. 31 B c

ATOM 11083 O SER B 96 -74. ,104 18. 119 -61. ,260 1. 00 50. 72 B 0

ATOM 11085 N GLN B 97 -72. 771 17. 004 -62. ,687 1. 00 60. 60 B N

ATOM 11086 CA GLN B 97 -71. 782 18. 067 -62. ,717 1. 00 64. 11 B c

ATOM 11088 CB GLN B 97 -71. 061 18. 134 -61. ,353 1. 00 67. 47 B C

ATOM 11091 CG GLN B 97 -69. 681 17. 496 -61. ,293 1. 00 68. 83 B C

ATOM 11094 CD GLN B 97 -69. 143 17. 453 -59. ,876 1. 00 70. 75 B C

ATOM 11095 OEl GLN B 97 -68. 367 18. 321 -59. ,471 1. 00 74. ,81 B 0

ATOM 11096 NE2 GLN B 97 -69. 567 16. 454 -59. ,107 1. 00 70. ,54 B N

ATOM 11099 C GLN B 97 -70. ,775 17. 871 -63. ,854 1. 00 64. ,92 B c

ATOM 11100 O GLN B 97 -70. 645 16. 764 -64. ,363 1. 00 66. 22 B 0

ATOM 11102 N PRO B 98 -70. 042 18. 942 -64. ,227 1. 00 65. 76 B N

ATOM 11103 CA PRO B 98 -69. 207 19. 000 -65. ,438 1. 00 67. 03 B c

ATOM 11105 CB PRO B 98 -68. 620 20. 418 -65. ,391 1. 00 69. 03 B c

ATOM 11108 CG PRO B 98 -69. 529 21. 182 -64. ,510 1. 00 69. 86 B c

ATOM 11111 CD PRO B 98 -69. 959 20. 205 -63. ,473 1. 00 68. 91 B c

ATOM 11114 C PRO B 98 -68. 068 17. 972 -65. ,569 1. 00 68. 85 B c

ATOM 11115 O PRO B 98 -67. 731 17. 590 -66. ,688 1. 00 69. 69 B 0

ATOM 11116 N ASP B 99 -67. 479 17. 543 -64. ,453 1. 00 67. 50 B N

ATOM 11117 CA ASP B 99 -66. 301 16. 661 -64. ,488 1. 00 67. 34 B c

ATOM 11119 CB ASP B 99 -65. 188 17. 201 -63. ,573 1. 00 71. 82 B c

ATOM 11122 CG ASP B 99 -64. 911 18. 674 -63. ,787 1. 00 77. ,57 B c

ATOM 11123 ODl ASP B 99 -63. 755 19. 015 -64. ,129 1. 00 80. ,43 B 0

ATOM 11124 002 ASP B 99 -65. 844 19. 491 -63. ,609 1. 00 79. 27 B 0

ATOM 11125 C ASP B 99 -66. 594 15. 213 -64. ,071 1. 00 66. 28 B c

ATOM 11126 0 ASP B 99 -65. 716 14. 538 -63. ,517 1. 00 65. 18 B 0

ATOM 11128 N THR B 100 -67. 818 14. 746 -64. ,316 1. 00 63. 79 B N

ATOM 11129 CA THR B 100 -68. 205 13. 363 -64. ,019 1. 00 61. 55 B c

ATOM 11131 CB THR B 100 -68. 750 13. 150 -62. ,580 1. 00 62. 00 B c

ATOM 11133 OGl THR B 100 -69. 912 13. 965 -62. ,356 1. 00 63. 14 B 0

ATOM 11135 CG2 THR B 100 -67. 686 13. 446 -61. ,524 1. 00 62. 61 B c

ATOM 11139 C THR B 100 -69. 285 12. 937 -64. ,993 1. 00 59. 09 B c

ATOM 11140 0 THR B 100 -70. 160 13. 734 -65. ,350 1. 00 61. 10 B 0

ATOM 11142 N ILE B 101 -69. 236 11. 679 -65. ,411 1. 00 57. 50 B N

ATOM 11143 CA ILE B 101 -70. 316 11. 102 -66. ,218 1. 00 56. 65 B c

ATOM 11145 CB ILE B 101 -69. 812 10. 018 -67. ,223 1. 00 57. ,53 B c

ATOM 11147 CGl ILE B 101 -69. 033 8. 898 -66. ,521 1. 00 55. ,34 B c

ATOM 11150 CDl ILE B 101 -68. 848 7. 676 -67. ,389 1. 00 54. 69 B c

ATOM 11154 CG2 ILE B 101 -68. 962 10. 658 -68. ,324 1. 00 57. 41 B c

ATOM 11158 C ILE B 101 -71. 454 10. 548 -65. ,345 1. 00 54. ,12 B c

ATOM 11159 0 ILE B 101 -72. 443 10. 020 -65. ,854 1. 00 55. 10 B 0

ATOM 11161 N ASP B 102 -71. 323 10. 709 -64, ,034 1. 00 53. 33 B N

ATOM 11162 CA ASP B 102 -72. 312 10. 228 -63. ,095 1. 00 50. 87 B c

ATOM 11164 CB ASP B 102 -71. 624 10. 016 -61. ,747 1. 00 48. ,15 B c

ATOM 11167 CG ASP B 102 -70. 392 9. 160 -61.880 1. 00 44. 88 B c

ATOM 11168 ODl ASP B 102 -70. 502 8. 067 -62. ,453 1. 00 44. 48 B 0

ATOM 11169 002 ASP B 102 -69. 306 9. 589 -61, ,457 1. 00 49. 04 B 0

ATOM 11170 C ASP B 102 -73. 533 11. 158 -63. .030 1. 00 47. 91 B c

ATOM 11171 0 ASP B 102 -73. 415 12. 385 -63. ,188 1. 00 45. ,45 B 0

ATOM 11173 N HIS B 103 -74. 700 10. 536 -62. ,842 1. 00 45. ,74 B N

ATOM 11174 CA HIS B 103 -75. 986 11. 231 -62. ,664 1. 00 44. ,61 B c

ATOM 11176 CB HIS B 103 -75. 937 11.982 -61. ,336 1. 00 42. ,70 B c

ATOM 11179 CG HIS B 103 -75. 035 11. 326 -60. .339 1. 00 38. ,07 B c

ATOM 11180 NDl HIS B 103 -75. 187 10. 012 -59. .963 1. 00 37. ,88 B N

ATOM 11182 CEl HIS B 103 -74. 245 9. 694 -59, ,094 1. 00 41. ,34 B c

ATOM 11184 NE2 HIS B 103 -73. 469 10. 748 -58. .918 1. 00 40. ,14 B N

ATOM 11186 CD2 HIS B 103 -73. 935 11. 778 -59. .695 1. 00 38. 29 B C

ATOM 11188 C HIS B 103 -76. 340 12. 139 -63. ,841 1. 00 43. ,08 B C

ATOM 11189 0 HIS B 103 -76. 933 13. ,189 -63. ,671 1. 00 40. ,28 B 0

ATOM 11191 N ASP B 104 -76. 003 11. 688 -65. ,045 1. 00 44. ,63 B N

ATOM 11192 CA ASP B 104 -76. 053 12. 523 -66 , ,249 1. 00 42. ,78 B c

ATOM 11194 CB ASP B 104 -74. 973 12. 062 -67, ,243 1. 00 41. ,39 B c

ATOM 11197 CG ASP B 104 -74. 974 12. ,852 -68, .543 1. 00 43. ,53 B c human fD _Fab

ATOM 11198 ODl ASP B 104 -75. .396 14. 025 -68. 563 1.00 43.50 B 0

ATOM 11199 OD2 ASP B 104 -74. .554 12. 279 -69. ,564 1.00 45.73 B 0

ATOM 11200 C ASP B 104 -77. .453 12. 496 -66. ,878 1.00 43.12 B C

ATOM 11201 O ASP B 104 -77. ,645 12. 092 -68. 031 1.00 41.90 B 0

ATOM 11203 N LEU B 105 -78. ,427 12. 947 -66.096 1.00 42.61 B N

ATOM 11204 CA LEU B 105 -79. ,803 12. 983 -66. 516 1.00 43.80 B C

ATOM 11206 CB LEU B 105 -80. .637 12. 043 -65. 644 1.00 39.70 B c

ATOM 11209 CG LEU B 105 -80. .528 10. 540 -65. ,891 1.00 37.49 B c

ATOM 11211 CDl LEU B 105 -81.518 9. 803 -64. ,981 1.00 35.22 B c

ATOM 11215 CD2 LEU B 105 -80. .769 10. 179 -67. ,371 1.00 34.03 B c

ATOM 11219 C LEU B 105 -80. ,342 14. 408 -66. ,418 1.00 45.53 B c

ATOM 11220 O LEU B 105 -79. .954 15. 177 -65. ,549 1.00 47.30 B 0

ATOM 11222 N LEU B 106 -81.245 14. 751 -67. 323 1.00 49.04 B N

ATOM 11223 CA LEU B 106 -81. .839 16. 077 -67. 355 1.00 48.75 B c

ATOM 11225 CB LEU B 106 -81.082 16. 971 -68. 340 1.00 51.49 B c

ATOM 11228 CG LEU B 106 -81. ,481 18. 441 -68. 511 1.00 50.81 B c

ATOM 11230 CDl LEU B 106 -81.600 19. 133 -67. 176 1.00 49.67 B c

ATOM 11234 CD2 LEU B 106 -80. ,445 19. 150 -69. 380 1.00 51.33 B c

ATOM 11238 C LEU B 106 -83. ,283 15. 950 -67. 777 1.00 47.63 B c

ATOM 11239 O LEU B 106 -83. ,586 15. 302 -68. 780 1.00 42.64 B 0

ATOM 11241 N LEU B 107 -84. .165 16. 573 -67. ,001 1.00 48.66 B N

ATOM 11242 CA LEU B 107 -85. ,600 16. 536 -67. 250 1.00 50.21 B c

ATOM 11244 CB LEU B 107 -86. ,296 16. 091 -65. ,947 1.00 49.03 B c

ATOM 11247 CG LEU B 107 -87. .279 14. 903 -65. ,896 1.00 47.89 B c

ATOM 11249 CDl LEU B 107 -86. ,986 14. 056 -64. 650 1.00 40.79 B c

ATOM 11253 CD2 LEU B 107 -87. ,276 14. 022 -67. 152 1.00 46.84 B c

ATOM 11257 C LEU B 107 -86. ,066 17. 930 -67. 732 1.00 50.02 B c

ATOM 11258 O LEU B 107 -85. ,934 18. 920 -67. 012 1.00 51.00 B 0

ATOM 11260 N LEU B 108 -86. ,573 18. 000 -68. 963 1.00 51.22 B N

ATOM 11261 CA LEU B 108 -87. ,039 19. 261 -69. 571 1.00 51.41 B c

ATOM 11263 CB LEU B 108 -86. ,643 19. 335 -71. 062 1.00 46.27 B c

ATOM 11266 CG LEU B 108 -85. ,237 19. 687 -71. 566 1.00 39.43 B c

ATOM 11268 CDl LEU B 108 -84. ,421 20. 422 -70. 505 1.00 34.88 B c

ATOM 11272 CD2 LEU B 108 -84. ,530 18. 442 -72. 067 1.00 37.66 B c

ATOM 11276 C LEU B 108 -88. ,565 19. 383 -69. 503 1.00 51.91 B c

ATOM 11277 O LEU B 108 -89. ,273 18. 494 -69. 982 1.00 47.90 B 0

ATOM 11279 N GLN B 109 -89. ,070 20. 489 -68. 955 1.00 54.25 B N

ATOM 11280 CA GLN B 109 -90. ,517 20. 757 -68. ,955 1.00 55.79 B C

ATOM 11282 CB GLN B 109 -90. ,969 21. 425 -67. ,651 1.00 56.88 B C

ATOM 11285 CG GLN B 109 -92. ,500 21. 547 -67. 521 1.00 57.05 B c

ATOM 11288 CD GLN B 109 -92. ,971 21. 961 -66. 126 1.00 55.71 B c

ATOM 11289 OEl GLN B 109 -92, ,328 22. 761 -65. 441 1.00 57.79 B 0

ATOM 11290 NE2 GLN B 109 -94. ,112 21. 420 -65. 709 1.00 52.33 B N

ATOM 11293 C GLN B 109 -90. ,895 21. 632 -70. 149 1.00 57.11 B c

ATOM 11294 0 GLN B 109 -90. ,407 22. 755 -70. 286 1.00 55.49 B 0

ATOM 11296 N LEU B 110 -91.771 21. 116 -71. 006 1.00 59.11 B N

ATOM 11297 CA LEU B 110 -92. ,167 21. 818 -72. ,227 1.00 61.02 B c

ATOM 11299 CB LEU B 110 -92. .901 20. 862 -73. ,179 1.00 58.76 B c

ATOM 11302 CG LEU B 110 -92, ,141 19. 612 -73. ,633 1.00 56.58 B c

ATOM 11304 CDl LEU B 110 -93. ,068 18. 660 -74. ,371 1.00 54.86 B c

ATOM 11308 CD2 LEU B 110 -90, ,946 19. 989 -74. ,494 1.00 54.48 B c

ATOM 11312 C LEU B 110 -93. .061 23. 016 -71. ,902 1.00 63.40 B c

ATOM 11313 0 LEU B 110 -93. ,645 23. 091 -70. ,805 1.00 62.47 B 0

ATOM 11315 N SE B 111 -93. ,171 23. 934 -72. ,870 1.00 64.59 B N

ATOM 11316 CA SER B 111 -93. ,943 25. 179 -72. 712 1.00 63.42 B c

ATOM 11318 CB SER B 111 -93, ,911 26. 014 -74. ,008 1.00 63.47 B c

ATOM 11321 OG SER B 111 -94. ,280 25. 252 -75. ,147 1.00 62.00 B 0

ATOM 11323 C SER B 111 -95. ,387 24. 893 -72. ,288 1.00 62.76 B c

ATOM 11324 0 SER B 111 -95. ,979 25. 631 -71. ,495 1.00 63.38 B 0

ATOM 11326 N GLU B 112 -95. .935 23. ,812 -72. ,832 1.00 61.49 B N

ATOM 11327 CA GLU B 112 -97, ,228 23. 282 -72. ,417 1.00 62.27 B c

ATOM 11329 CB GLU B 112 -98, .367 23. ,958 -73. ,193 1.00 64.09 B c

ATOM 11332 CG GLU B 112 -98, .189 23. 930 -74. ,717 1.00 65.12 B c

ATOM 11335 CD GLU B 112 -99, ,502 23. ,798 -75. ,464 1.00 64.38 B c

ATOM 11336 OEl GLU B 112 -100, .447 24. ,544 -75. ,138 1.00 65.16 B 0

ATOM 11337 OE2 GLU B 112 -99. .582 22. ,946 -76. ,374 1.00 63.64 B 0

ATOM 11338 C GLU B 112 -97. .211 21. 775 -72. ,684 1.00 58.81 B c

ATOM 11339 0 GLU B 112 -96. ,255 21. 263 -73. ,265 1.00 55.46 B 0 human fD _Fab

ATOM 11341 N LYS B 113 -98, ,265 21. 070 -72. 282 1.00 59.73 B N

ATOM 11342 CA LYS B 113 -98. .382 19. 650 -72. 606 1.00 61.54 B C

ATOM 11344 CB LYS B 113 -99. ,754 19. 086 -72. 200 1.00 64.42 B C

ATOM 11347 CG LYS B 113 -100. ,944 19. 590 -73. 039 1.00 66.84 B c

ATOM 11350 CD LYS B 113 -102. ,111 18. 608 -73. 007 1.00 67.03 B c

ATOM 11353 CE LYS B 113 -103. ,259 19. 027 -73. 925 1.00 66.41 B c

ATOM 11356 NZ LYS B 113 -103. ,014 18. 636 -75. 343 1.00 65.62 B N

ATOM 11360 C LYS B 113 -98. ,143 19. 427 -74. ,100 1.00 61.42 B C

ATOM 11361 O LYS B 113 -98. ,523 20. 258 -74. 934 1.00 61.38 B 0

ATOM 11363 N ALA B 114 -97. ,510 18. 306 -74. 432 1.00 61.36 B N

ATOM 11364 CA ALA B 114 -97. ,228 17. 974 -75. 821 1.00 59.71 B C

ATOM 11366 CB ALA B 114 -96. ,151 16. 892 -75. 915 1.00 60.31 B C

ATOM 11370 C ALA B 114 -98. ,495 17. 508 -76. 526 1.00 57.52 B C

ATOM 11371 O ALA B 114 -99. ,247 16. 680 -76. 002 1.00 57.41 B 0

ATOM 11373 N THR B 115 -98. ,723 18. 054 -77. 717 1.00 56.62 B N

ATOM 11374 CA THR B 115 -99. ,827 17. 628 -78. 570 1.00 57.39 B c

ATOM 11376 CB THR B 115 -99. ,973 18. 547 -79. 837 1.00 55.99 B c

ATOM 11378 OGl THR B 115 -100. ,245 19. 900 -79. 438 1.00 51.25 B 0

ATOM 11380 CG2 THR B 115 -101. ,092 18. 055 -80. 764 1.00 55.21 B c

ATOM 11384 C THR B 115 -99. ,557 16. 182 -78. 980 1.00 59.05 B c

ATOM 11385 O THR B 115 -98. ,685 15. 918 -79. 815 1.00 58.37 B 0

ATOM 11387 N LEU B 116 -100. ,291 15. 257 -78. 360 1.00 58.81 B N

ATOM 11388 CA LEU B 116 -100. ,137 13. 828 -78. 617 1.00 57.77 B c

ATOM 11390 CB LEU B 116 -100. ,797 12. 998 -77. 498 1.00 58.91 B c

ATOM 11393 CG LEU B 116 -100. ,047 12. 855 -76. 167 1.00 57.12 B c

ATOM 11395 CDl LEU B 116 -100. ,877 12. 093 -75. 132 1.00 56.49 B c

ATOM 11399 CD2 LEU B 116 -98. ,732 12. 153 -76.399 1.00 56.46 B c

ATOM 11403 C LEU B 116 -100. ,748 13. 455 -79. 959 1.00 56.47 B c

ATOM 11404 O LEU B 116 -101. ,627 14. 155 -80. 467 1.00 57.53 B 0

ATOM 11406 N GLY B 117 -100. ,287 12. 339 -80. 516 1.00 57.78 B N

ATOM 11407 CA GLY B 117 -100. ,760 11. 856 -81. 814 1.00 58.80 B C

ATOM 11410 C GLY B 117 -100. ,096 10. 537 -82. 182 1.00 60.62 B C

ATOM 11411 O GLY B 117 -99. ,468 9. 901 -81. 327 1.00 62.17 B 0

ATOM 11413 N PRO B 118 -100. ,223 10. 111 -83. 455 1.00 60.62 B N

ATOM 11414 CA PRO B 118 -99. ,566 8. 860 -83. ,873 1.00 60.67 B C

ATOM 11416 CB PRO B 118 -100. ,104 8. 635 -85. ,298 1.00 60.75 B C

ATOM 11419 CG PRO B 118 -100. ,485 9. 985 -85. ,781 1.00 60.79 B C

ATOM 11422 CD PRO B 118 -100. ,956 10. 745 -84. 567 1.00 60.78 B c

ATOM 11425 C PRO B 118 -98. ,031 8. 953 -83. 883 1.00 59.33 B c

ATOM 11426 0 PRO B 118 -97. ,352 7. 938 -83. 703 1.00 55.34 B 0

ATOM 11427 N ALA B 119 -97. ,517 10. 170 -84. 088 1.00 60.31 B N

ATOM 11428 CA ALA B 119 -96. ,078 10. 437 -84. 194 1.00 57.34 B c

ATOM 11430 CB ALA B 119 -95. ,806 11. 299 -85. ,432 1.00 58.97 B c

ATOM 11434 C ALA B 119 -95. ,467 11.107 -82. ,949 1.00 55.03 B c

ATOM 11435 0 ALA B 119 -94, ,265 11. ,389 -82. 936 1.00 57.39 B 0

ATOM 11437 N VAL B 120 -96. ,282 11.365 -81. 922 1.00 52.91 B N

ATOM 11438 CA VAL B 120 -95, ,817 12. 014 -80. 680 1.00 55.41 B c

ATOM 11440 CB VAL B 120 -96. ,171 13. 523 -80. 662 1.00 56.63 B c

ATOM 11442 CGI VAL B 120 -96. ,160 14. 075 -79. 236 1.00 56.92 B c

ATOM 11446 CG2 VAL B 120 -95, ,209 14. 303 -81. ,548 1.00 58.85 B c

ATOM 11450 C VAL B 120 -96. .440 11. 342 -79. ,457 1.00 57.68 B c

ATOM 11451 0 VAL B 120 -97, .658 11. 373 -79. ,287 1.00 59.55 B 0

ATOM 11453 N ARG B 121 -95. .603 10. 748 -78. ,603 1.00 61.68 B N

ATOM 11454 CA ARG B 121 -96. .095 9. ,929 -77. ,492 1.00 62.38 B c

ATOM 11456 CB ARG B 121 -96. .642 8. ,629 -78. ,053 1.00 68.95 B c

ATOM 11459 CG ARG B 121 -97. ,544 7. ,927 -77. ,105 1.00 73.56 B c

ATOM 11462 CD ARG B 121 -97. ,496 6. 466 -77. ,327 1.00 78.28 B c

ATOM 11465 NE ARG B 121 -98. ,721 5. 861 -76. ,849 1.00 80.78 B N

ATOM 11467 CZ ARG B 121 -98. ,909 4. 556 -76. ,726 1.00 82.60 B c

ATOM 11468 NHl ARG B 121 -97. ,958 3. 677 -77. ,040 1.00 82.61 B N

ATOM 11471 NH2 ARG B 121 -100. .071 4. ,128 -76. ,301 1.00 83.06 B N

ATOM 11474 C ARG B 121 -95. .021 9. 568 -76. ,452 1.00 60.97 B C

ATOM 11475 0 ARG B 121 -93. ,903 9. 215 -76. ,827 1.00 59.73 B 0

ATOM 11477 N PRO B 122 -95. ,364 9. 622 -75. ,143 1.00 60.19 B N

ATOM 11478 CA PRO B 122 -94. ,394 9. ,206 -74. ,127 1.00 57.80 B C

ATOM 11480 CB PRO B 122 -95. ,136 9. 467 -72. 807 1.00 59.14 B C

ATOM 11483 CG PRO B 122 -96. ,572 9. ,450 -73. 167 1.00 60.35 B c

ATOM 11486 CD PRO B 122 -96. ,619 10. ,087 -74. 518 1.00 61.00 B c human fD_Fab

ATOM 11489 C PRO ^" B 122 -93 .988 7. ,731 -74, .209 1.00 55. ,47 B C

ATOM 11490 O PRO B 122 -94, .762 6. ,906 -74, .706 1.00 53. .86 B 0

ATOM 11491 N LEU B 123 -92. .780 7. ,426 -73, .724 1.00 53. ,68 B N

ATOM 11492 CA LEU B 123 -92, .264 6, ,055 -73, .605 1.00 54. ,97 B C

ATOM 11494 CB LEU B 123 -90, .839 5. ,976 -74, .165 1.00 55. ,02 B C

ATOM 11497 CG LEU B 123 -90, .263 4. ,657 -74, .703 1.00 55. ,12 B c

ATOM 11499 CDl LEU B 123 -88, .832 4. ,885 -75, .191 1.00 54. ,67 B c

ATOM 11503 CD 2 LEU B 123 -90, .279 3. ,541 -73, .678 1.00 53. ,89 B c

ATOM 11507 C LEU B 123 -92, .248 5. ,644 -72, .123 1.00 54. ,69 B c

ATOM 11508 O LEU B 123 -91, .752 6. ,395 -71.276 1.00 56. ,50 B 0

ATOM 11510 N PRO B 124 -92. .804 4. ,462 -71.797 1.00 53. ,24 B N

ATOM 11511 CA PRO B 124 -92. .632 3. ,954 -70, .437 1.00 53. ,16 B c

ATOM 11513 CB PRO B 124 -93. .514 2. ,693 -70, .404 1.00 52. ,35 B c

ATOM 11516 CG PRO B 124 -94. ,389 2. ,774 -71. .597 1.00 52. ,61 B c

ATOM 11519 CD PRO B 124 -93. ,631 3. ,556 -72, .617 1.00 53. 93 B c

ATOM 11522 C PRO B 124 -91. ,160 3. ,626 -70. .121 1.00 50. ,91 B c

ATOM 11523 O PRO B 124 -90. ,443 3. ,064 -70, .958 1.00 45. 58 B 0

ATOM 11524 N TRP B 125 -90. ,723 3. 980 -68. .919 1.00 49. ,61 B N

ATOM 11525 CA TRP B 125 -89. ,331 3. ,808 -68. .526 1.00 50. ,18 B c

ATOM 11527 CB TRP B 125 -88. ,714 5. ,143 -68. .099 1.00 50. 09 B c

ATOM 11530 CG TRP B 125 -89. ,436 5. ,897 -67. ,005 1.00 50. 06 B c

ATOM 11531 CDl TRP B 125 -90. ,404 6. ,856 -67. ,163 1.00 51. ,41 B c

ATOM 11533 NEl TRP B 125 -90. ,799 7. 342 -65. ,931 1.00 51. ,08 B N

ATOM 11535 CE2 TRP B 125 -90. ,080 6. ,704 -64. ,954 1.00 48. 96 B c

ATOM 11536 CD2 TRP B 125 -89. ,209 5. 790 -65. ,592 1.00 49. 59 B c

ATOM 11537 CE3 TRP B 125 -88. ,360 5. ,005 -64. ,804 1.00 50. 78 B c

ATOM 11539 CZ3 TRP B 125 -88. ,405 5. ,151 -63. ,416 1.00 50. 64 B c

ATOM 11541 CH2 TRP B 125 -89. ,287 6. 066 -62. ,815 1.00 50. 32 B c

ATOM 11543 CZ2 TRP B 125 -90. ,130 6. 847 -63. ,565 1.00 49. 16 B c

ATOM 11545 c TRP B 125 -89. ,207 2. 773 -67. ,418 1.00 48. 81 B c

ATOM 11546 0 TRP B 125 -90. ,137 2. 593 -66. ,625 1.00 51.59 B 0

ATOM 11548 N GLN B 126 -88. ,062 2. 089 -67. ,386 1.00 48. 29 B N

ATOM 11549 CA GLN B 126 -87. ,846 0. 952 -66. ,487 1.00 50. 80 B c

ATOM 11551 CB GLN B 126 -86. ,544 0. 217 -66. ,857 1.00 50. 70 B c

ATOM 11554 CG GLN B 126 -86. ,187 -0. 978 -65. ,962 1.00 51. 68 B c

ATOM 11557 CD GLN B 126 -87. ,258 -2. 058 -65. ,942 1.00 53. 58 B c

ATOM 11558 OEl GLN B 126 -87. ,751 -2. 430 -64. ,876 1.00 52. 35 B 0

ATOM 11559 NE2 GLN B 126 -87. ,625 -2. 565 -67. ,123 1.00 53. 10 B N

ATOM 11562 C GLN B 126 -87. 818 1. 392 -65. ,028 1.00 50. 85 B c

ATOM 11563 0 GLN B 126 -87. 001 2. 217 -64. ,631 1.00 48. 11 B 0

ATOM 11565 N ARG B 127 -88. 719 0. 827 -64. ,235 1.00 54. 38 B N

ATOM 11566 CA ARG B 127 -88. 881 1. 214 -62. ,837 1.00 56. 27 B c

ATOM 11568 CB ARG B 127 -90. 374 1. 261 -62. ,477 1.00 58. 94 B c

ATOM 11571 CG ARG B 127 -90. 674 1. 829 -61. ,082 1.00 58. 79 B c

ATOM 11574 CD ARG B 127 -92. 167 2. 107 -60. ,877 1.00 57. 48 B c

ATOM 11577 NE ARG B 127 -92. 718 2. 966 -61. ,926 1.00 57. 14 B N

ATOM 11579 cz ARG B 127 -92. 583 4. 291 -61. ,993 1.00 55. 70 B c

ATOM 11580 NHl ARG B 127 -91. 907 4. 961 -61. ,065 1.00 53. 14 B N

ATOM 11583 NH2 ARG B 127 -93. 134 4. 955 -63. ,008 1.00 55. 80 B N

ATOM 11586 C ARG B 127 -88. 154 0. 255 -61. ,907 1.00 56. 08 B C

ATOM 11587 0 ARG B 127 -87. 722 0. 652 -60. ,819 1.00 57. 18 B 0

ATOM 11589 N VAL B 128 -88. 034 -1. 003 -62. ,331 1.00 55. 64 B N

ATOM 11590 CA VAL B 128 -87. 405 -2. 039 -61. ,516 1.00 55. 43 B C

ATOM 11592 CB VAL B 128 -87. 945 -3. 455 -61. ,835 1.00 57. 03 B C

ATOM 11594 CGI VAL B 128 -87. 310 -4. 496 -60. ,909 1.00 54. 72 B C

ATOM 11598 CG2 VAL B 128 -89. 466 -3. 485 -61. ,717 1.00 57. 50 B c

ATOM 11602 C VAL B 128 -85. 894 -1. 994 -61. ,727 1.00 57. 44 B C

ATOM 11603 0 VAL B 128 -85. 403 -2. 075 -62. ,859 1.00 54. 36 B 0

ATOM 11605 N ASP B 129 -85. 173 -1. 869 -60. 618 1.00 57. 78 B N

ATOM 11606 CA ASP B 129 -83. 736 -1. 660 -60. 643 1.00 56. 51 B c

ATOM 11608 CB ASP B 129 -83. 291 -0. 817 -59. 425 1.00 57. 96 B c

ATOM 11611 CG ASP B 129 -81. 811 -0. 373 -59. 490 1.00 57. 89 B c

ATOM 11612 001 ASP B 129 -80. 968 -1. 050 -60. 116 1.00 54. 48 B 0

ATOM 11613 OD2 ASP B 129 -81. 486 0. 662 -58. 877 1.00 58. 16 B 0

ATOM 11614 C ASP B 129 -83. 041 -3. 016 -60. 679 1.00 55. 29 B c

ATOM 11615 0 ASP B 129 -82. 609 -3. 545 -59. 653 1.00 48. 83 B 0

ATOM 11617 N ARG B 130 -82. 966 -3. 585 -61. 875 1.00 57. 48 B N

ATOM 11618 CA ARG B 130 -82. 086 -4. 713 -62. 112 1.00 58. 30 B c human fD_Fab

ATOM 11620 CB ARG B 130 -82. ,792 -6. 038 -61. 729 1.00 66. 44 B C

ATOM 11623 CG ARG B 130 -83. 060 -7. 071 -62. 824 1.00 74. 66 B C

ATOM 11626 CD ARG B 130 -84. 101 -6. 631 -63. 859 1.00 82. 57 B C

ATOM 11629 NE ARG B 130 -85. 480 -6. 679 -63. 369 1.00 85. 90 B N

ATOM 11631 CZ ARG B 130 -86. 218 -7. 785 -63. 258 1.00 86. 98 B C

ATOM 11632 NHl ARG B 130 -85. 722 -8. 983 -63. 582 1.00 87. 05 B N

ATOM 11635 NH2 ARG B 130 -87. 466 -7. 689 -62. 804 1.00 86. 72 B N

ATOM 11638 C ARG B 130 -81. ,558 -4. 646 -63. 547 1.00 54. 92 B C

ATOM 11639 0 ARG B 130 -82. 189 -4. 056 -64. 433 1.00 50. 70 B 0

ATOM 11641 N ASP B 131 -80. 365 -5. 197 -63. 745 1.00 50. 54 B N

ATOM 11642 CA ASP B 131 -79. 663 -5. 081 -65. 014 1.00 48. 70 B C

ATOM 11644 CB ASP B 131 -78. 289 -5. 764 -64. 926 1.00 47. 57 B C

ATOM 11647 CG ASP B 131 -77. 264 -4. 963 -64. 129 1.00 46. 61 B C

ATOM 11648 ODl ASP B 131 -77. 381 -3. 718 -64. 043 1.00 45. 17 B 0

ATOM 11649 OD2 ASP B 131 -76. 321 -5. 598 -63. 603 1.00 42. 10 B 0

ATOM 11650 C ASP B 131 -80. 432 -5. 713 -66. 168 1.00 44. 79 B c

ATOM 11651 0 ASP B 131 -81. 080 -6. 741 -66. 008 1.00 48. 07 B 0

ATOM 11653 N VAL B 132 -80. 336 -5. 088 -67. 334 1.00 42. 65 B N

ATOM 11654 CA VAL B 132 -80. 650 -5. 763 -68. 575 1.00 40. 34 B c

ATOM 11656 CB VAL B 132 -80. 680 -4. 784 -69. 768 1.00 34. 67 B c

ATOM 11658 CGI VAL B 132 -80. 910 -5. 526 -71. 096 1.00 32. 86 B c

ATOM 11662 CG2 VAL B 132 -81. 754 -3. 726 -69. 553 1.00 31. 43 B c

ATOM 11666 C VAL B 132 -79. 597 -6. 856 -68. 771 1.00 41. 76 B c

ATOM 11667 0 VAL B 132 -78. 398 -6. 627 -68. 615 1.00 43. 96 B 0

ATOM 11669 N ALA B 133 -80. 063 -8. 057 -69. 080 1.00 45. 13 B N

ATOM 11670 CA ALA B 133 -79. 200 -9. 212 -69. 240 1.00 41. 07 B c

ATOM 11672 CB ALA B 133 -80. 053 -10. 457 -69. 535 1.00 41. 02 B c

ATOM 11676 C ALA B 133 -78. 178 -8. 970 -70. 356 1.00 38. 15 B c

ATOM 11677 0 ALA B 133 -78. 505 -8. 327 -71. 358 1.00 38. 44 B 0

ATOM 11679 N PRO B 134 -76. 935 -9. 463 -70. 173 1.00 36. 48 B N

ATOM 11680 CA PRO B 134 -75. 892 -9. 434 -71. 210 1.00 37. 35 B C

ATOM 11682 CB PRO B 134 -74. 762 -10. 258 -70. 594 1.00 37. 67 B C

ATOM 11685 CG PRO B 134 -74. 976 -10. 156 -69. 118 1.00 38. 52 B c

ATOM 11688 CD PRO B 134 -76. 454 -10. 072 -68. 921 1.00 36. 70 B c

ATOM 11691 C PRO B 134 -76. 365 -10.098 -72. 505 1.00 41. 04 B c

ATOM 11692 0 PRO B 134 -77. 054 -11. 122 -72. 459 1.00 44. 48 B 0

ATOM 11693 N GLY B 135 -76. 014 -9. 514 -73. 645 1.00 39. 63 B N

ATOM 11694 CA GLY B 135 -76. 446 -10. 037 -74. 929 1.00 38. 19 B c

ATOM 11697 C GLY B 135 -77. 808 -9. 554 -75. ,389 1.00 39. ,74 B c

ATOM 11698 0 GLY B 135 -78. 109 -9. 636 -76. 584 1.00 40. 99 B 0

ATOM 11700 N THR B 136 -78. 637 -9. 050 -74. ,464 1.00 38. ,18 B N

ATOM 11701 CA THR B 136 -79. 969 -8. 539 -74. 809 1.00 39. ,24 B c

ATOM 11703 CB THR B 136 -80. 704 -8. 017 -73. ,570 1.00 38. ,20 B c

ATOM 11705 OGl THR B 136 -80. 808 -9. 073 -72. 606 1.00 39. ,12 B 0

ATOM 11707 CG2 THR B 136 -82. 099 -7. 509 -73. ,929 1.00 35. 94 B c

ATOM 11711 C THR B 136 -79. 842 -7. 443 -75. 856 1.00 39. ,86 B c

ATOM 11712 0 THR B 136 -78. 976 -6. 590 -75. 755 1.00 43. 99 B 0

ATOM 11714 N LEU B 137 -80. 693 -7. 486 -76. 872 1.00 42. ,83 B N

ATOM 11715 CA LEU B 137 -80. 529 -6. 638 -78. 052 1.00 43. ,42 B c

ATOM 11717 CB LEU B 137 -80. ,874 -7. 443 -79. ,314 1.00 45. ,20 B c

ATOM 11720 CG LEU B 137 -80. ,150 -7. ,128 -80. ,628 1.00 45. ,64 B c

ATOM 11722 CDl LEU B 137 -78. 629 -7. 071 -80. ,473 1.00 44. ,27 B c

ATOM 11726 CD2 LEU B 137 -80. 536 -8. 171 -81. ,675 1.00 44. ,43 B c

ATOM 11730 C LEU B 137 -81.431 -5. 415 -77. ,878 1.00 44. ,16 B c

ATOM 11731 0 LEU B 137 -82. 640 -5. 556 -77. ,722 1.00 45. ,91 B 0

ATOM 11733 N CYS B 138 -80. 820 -4. 227 -77. ,863 1.00 41. ,36 B N

ATOM 11734 CA CYS B 138 -81. 506 -2. 968 -77. ,568 1.00 37. ,98 B c

ATOM 11736 CB CYS B 138 -80. 903 -2. 329 -76. ,329 1.00 35. ,02 B c

ATOM 11739 SG CYS B 138 -80. 915 -3. 414 -74. ,934 1.00 38. ,12 B s

ATOM 11741 C CYS B 138 -81. 399 -1. 968 -78. ,697 1.00 35. ,71 B c

ATOM 11742 0 CYS B 138 -80. ,466 -1. ,998 -79. ,479 1.00 32. ,54 B 0

ATOM 11744 N ASP B 139 -82. 339 -1. ,036 -78. ,729 1.00 39. ,31 B N

ATOM 11745 CA ASP B 139 -82. 448 -0. ,094 -79. ,827 1.00 38. ,89 B c

ATOM 11747 CB ASP B 139 -83. ,877 -0. 119 -80. ,360 1.00 38. ,98 B c

ATOM 11750 CG ASP B 139 -84. 032 0. ,648 -81.647 1.00 38. ,99 B c

ATOM 11751 ODl ASP B 139 -83. 330 0. 318 -82. 619 1.00 41. ,91 B 0

ATOM 11752 OD2 ASP B 139 -84. 862 1. 578 -81. ,683 1.00 34. ,77 B 0

ATOM 11753 C ASP B 139 -82. 092 1. 300 -79. ,347 1.00 37. ,72 B c human fD_Fab

ATOM 11754 O ASP B 139 -82. 741 1. ,813 -78. 433 1. 00 36. 18 B 0

ATOM 11756 N VAL B 140 -81.049 1. ,894 -79. 932 1. 00 36. 52 B N

ATOM 11757 CA VAL B 140 -80. 733 3. ,310 -79. 705 1. 00 36. 92 B C

ATOM 11759 CB VAL B 140 -79. 309 3. ,533 -79. 104 1. 00 37. 70 B C

ATOM 11761 CGl VAL B 140 -78. 212 3. ,055 -80. 060 1. 00 36. 88 B c

ATOM 11765 CG2 VAL B 140 -79. 110 5. ,006 -78. 756 1. 00 37. 68 B c

ATOM 11769 C VAL B 140 -80. 921 4. 104 -81.007 1. 00 35. 48 B c

ATOM 11770 O VAL B 140 -80. 501 3. 665 -82. 083 1. 00 30. 92 B 0

ATOM 11772 N ALA B 141 -81. 580 5. 260 -80. 897 1. 00 37. 70 B N

ATOM 11773 CA ALA B 141 -81.850 6. 127 -82. 047 1. 00 37. 88 B c

ATOM 11775 CB ALA B 141 -83. 327 6. 171 -82. 338 1. 00 38. 39 B c

ATOM 11779 C ALA B 141 -81. 323 7. 532 -81. 796 1. 00 38. 12 B c

ATOM 11780 O ALA B 141 -81. 138 7. ,941 -80. 640 1. 00 33. 18 B 0

ATOM 11782 N GLY B 142 -81. 071 8. ,265 -82. 882 1. 00 38. 25 B N

ATOM 11783 CA GLY B 142 -80. 536 9. ,626 -82. 764 1. 00 39. 96 B c

ATOM 11786 C GLY B 142 -80. 104 10. ,298 -84. 056 1. 00 40. 04 B c

ATOM 11787 O GLY B 142 -79. 979 9. ,650 -85. 103 1. 00 34. 84 B 0

ATOM 11789 N TRP B 143 -79. 863 11. 609 -83. 955 1. 00 41. 03 B N

ATOM 11790 CA TRP B 143 -79. 400 12. 444 -85. 076 1. 00 40. 97 B C

ATOM 11792 CB TRP B 143 -80. 182 13. 766 -85. 134 1. 00 47. 60 B C

ATOM 11795 CG TRP B 143 -81. 582 13. 693 -85. 639 1. 00 48. 60 B C

ATOM 11796 CDl TRP B 143 -81. 988 13. 740 -86. 945 1. 00 49. 15 B C

ATOM 11798 NEl TRP B 143 -83. 357 13. 676 -87. 015 1. 00 49. 21 B N

ATOM 11800 CE2 TRP B 143 -83. 866 13. 605 -85. 744 1. 00 48. 62 B C

ATOM 11801 CD2 TRP B 143 -82. 771 13. 625 -84. 849 1. 00 48. 55 B C

ATOM 11802 CE3 TRP B 143 -83. 018 13. 565 -83. 470 1. 00 48. 19 B C

ATOM 11804 CZ3 TRP B 143 -84. 335 13. ,485 -83. 032 1. 00 49. 03 B C

ATOM 11806 CH2 TRP B 143 -85. 409 13. 466 -83. 948 1. 00 49. 31 B C

ATOM 11808 CZ2 TRP B 143 -85. 194 13. 526 -85. 305 1. 00 48. 96 B c

ATOM 11810 C TRP B 143 -77. 917 12. 799 -84. 916 1. 00 37. 57 B c

ATOM 11811 O TRP B 143 -77. 460 13. 834 -85. 413 1. 00 37. 74 B 0

ATOM 11813 N GLY B 144 -77. 172 11. 953 -84. 207 1. 00 39. 23 B N

ATOM 11814 CA GLY B 144 -75. 749 12. 183 -83. 990 1. 00 39. 27 B c

ATOM 11817 C GLY B 144 -74. 954 11. 759 -85. 202 1. 00 39. 01 B c

ATOM 11818 0 GLY B 144 -75. 513 11. 189 -86. 145 1. 00 37. 19 B 0

ATOM 11820 N ILE B 145 -73. 646 12. 015 -85. 174 1. 00 42. 40 B N

ATOM 11821 CA ILE B 145 -72. 803 11. 750 -86. 339 1. 00 42. 46 B c

ATOM 11823 CB ILE B 145 -71. 339 12. 242 -86. 152 1. 00 46. 02 B c

ATOM 11825 CGl ILE B 145 -70. 606 11. 437 -85. 075 1. 00 47. 50 B c

ATOM 11828 CDl ILE B 145 -69. 234 12. 010 -84. 691 1. 00 46. 45 B c

ATOM 11832 CG2 ILE B 145 -71. 320 13. ,746 -85. 822 1. 00 46. 04 B c

ATOM 11836 C ILE B 145 -72. 878 10. ,277 -86. 734 1. 00 41. 61 B c

ATOM 11837 0 ILE B 145 -73. 111 9. ,407 -85. 891 1. 00 39. 28 B 0

ATOM 11839 N VAL B 146 -72. 726 10. 033 -88. 036 1. 00 43. 82 B N

ATOM 11840 CA VAL B 146 -72. 927 8. ,715 -88. 663 1. 00 41. 36 B c

ATOM 11842 CB VAL B 146 -74. 039 8. ,811 -89. 719 1. 00 41. 29 B c

ATOM 11844 CGl VAL B 146 -75. 374 9. ,091 -89. 050 1. 00 40. 86 B c

ATOM 11848 CG2 VAL B 146 -73. 725 9. 908 -90. 740 1. 00 42. 13 B c

ATOM 11852 C VAL B 146 -71. 637 8. 152 -89. 298 1. 00 44. 20 B c

ATOM 11853 0 VAL B 146 -71. 643 7. 040 -89. 863 1. 00 40. 61 B 0

ATOM 11855 N ASN B 147 -70. 545 8. 918 -89. 185 1. 00 42. 75 B N

ATOM 11856 CA ASN B 147 -69. 217 8. 482 -89. 615 1. 00 45. 26 B c

ATOM 11858 CB ASN B 147 -69. 083 8. 591 -91. 134 1. 00 48. 77 B C

ATOM 11861 CG ASN B 147 -69. 250 10. 019 -91. 650 1. 00 50. 62 B c

ATOM 11862 ODl ASN B 147 -68. 492 10. ,929 -91. 291 1. 00 54. 60 B 0

ATOM 11863 ND2 ASN B 147 -70. 224 10. ,208 -92. 525 1. 00 46. 39 B N

ATOM 11866 C ASN B 147 -68. 113 9. ,280 -88. 908 1. 00 47. 04 B c

ATOM 11867 0 ASN B 147 -68. 392 10. ,290 -88. 258 1. 00 48. 73 B 0

ATOM 11869 N HIS B 148 -66. 865 8. ,835 -89. 045 1. 00 48. 71 B N

ATOM 11870 CA HIS B 148 -65. 732 9. ,484 -88. 360 1. 00 50. 38 B c

ATOM 11872 CB HIS B 148 -64. 497 8. ,582 -88. 348 1. 00 57. 68 B c

ATOM 11875 CG HIS B 148 -64. 676 7. ,340 -87. 542 1. 00 62. 31 B c

ATOM 11876 NDl HIS B 148 -65. 735 7. ,166 -86. 677 1. 00 64. 15 B N

ATOM 11878 CEl HIS B 148 -65. 640 5. ,981 -86. 104 1. 00 66. 50 B c

ATOM 11880 NE2 HIS B 148 -64. 548 5. 386 -86. 554 1. 00 68. 58 B N

ATOM 11882 CD2 HIS B 148 -63. 925 6. 217 -87. 453 1. 00 66. 66 B c

ATOM 11884 C HIS B 148 -65. 339 10. 839 -88. 935 1. 00 49. 41 B c

ATOM 11885 0 HIS B 148 -64. 560 11.567 -88. 321 1. 00 50. 94 B 0 human fD_Fab

ATOM 11887 N ALA B 149 -65. ,861 11. ,168 -90. ,112 1.00 48. ,74 B N

ATOM 11888 CA ALA B 149 -65. 680 12. ,492 -90. ,706 1.00 51. ,20 B C

ATOM 11890 CB ALA B 149 -65. 922 12. 422 -92. 223 1.00 52. ,48 B C

ATOM 11894 C ALA B 149 -66. 612 13. ,532 -90. ,069 1.00 54. ,00 B C

ATOM 11895 0 ALA B 149 -66. 578 14. ,706 -90. ,441 1.00 56. ,94 B 0

ATOM 11897 N GLY B 150 -67. 444 13. ,091 -89. ,123 1.00 55. ,74 B

ATOM 11898 CA GLY B 150 -68. 348 13. 967 -88. ,402 1.00 55. 65 B C

ATOM 11901 C GLY B 150 -69. ,509 14. 508 -89. 223 1.00 55. ,01 B C

ATOM 11902 0 GLY B 150 -69. 939 15. ,643 -88. 976 1.00 52. ,53 B 0

ATOM 11904 N ARG B 151 -70. 042 13. 723 -90. 172 1.00 57. 39 B N

ATOM 11905 CA ARG B 151 -71. ,304 14. ,109 -90. ,850 1.00 58. ,49 B c

ATOM 11907 CB ARG B 151 -71. ,643 13. ,128 -91. ,987 1.00 61.07 B c

ATOM 11910 CG ARG B 151 -72. ,592 13. ,737 -93. ,019 1.00 63. ,83 B c

ATOM 11913 CD ARG B 151 -72. 192 13. ,397 -94. ,455 1.00 68. ,13 B c

ATOM 11916 NE ARG B 151 -72. 318 11. 969 -94. ,746 1.00 70. ,83 B N

ATOM 11918 CZ ARG B 151 -73. ,475 11. 310 -94. ,855 1.00 71.35 B c

ATOM 11919 NHl ARG B 151 -74. 649 11. 929 -94. 685 1.00 69. ,11 B N

ATOM 11922 NH2 ARG B 151 -73. 459 10. 006 -95. 121 1.00 71. 36 B N

ATOM 11925 C ARG B 151 -72. 277 13. 933 -89. 663 1.00 57. ,96 B c

ATOM 11926 0 ARG B 151 -71.816 14. 531 -88. 426 1.00 60. ,24 B 0

ATOM 11928 N ARG B 152 -73. 584 13. 721 -89. 870 1.00 59. 61 B N

ATOM 11929 CA ARG B 152 -74. ,684 14. 639 -89. ,516 1.00 57. ,17 B c

ATOM 11931 CB ARG B 152 -74. ,407 16. ,163 -89. ,692 1.00 64. ,82 B c

ATOM 11934 CG ARG B 152 -73. ,521 16. 927 -88. 655 1.00 70. ,05 B c

ATOM 11937 CD ARG B 152 -73. 696 16. ,541 -87. 139 1.00 73. 03 B c

ATOM 11940 NE ARG B 152 -73. 119 17. ,564 -86. ,251 1.00 72. ,57 B N

ATOM 11942 CZ ARG B 152 -73. 103 17. 497 -84. 912 1.00 74. 97 B c

ATOM 11943 NHl ARG B 152 -73. 627 16. 450 -84. 272 1.00 75. 90 B N

ATOM 11946 NH2 ARG B 152 -72. 554 18. 483 -84. 201 1.00 75. 10 B N

ATOM 11949 C ARG B 152 -75. 877 14. 247 -90. 345 1.00 50. 51 B C

ATOM 11950 0 ARG B 152 -76. 043 14. 765 -91.436 1.00 49. 42 B 0

ATOM 11952 N PRO B 153 -76. 718 13. 334 -89. 843 1.00 48. 76 B N

ATOM 11953 CA PRO B 153 -77. 798 12. 879 -90. 701 1.00 47. 73 B C

ATOM 11955 CB PRO B 153 -78. 277 11. ,609 -90. ,005 1.00 46. ,95 B C

ATOM 11958 CG PRO B 153 -78. 060 11. 895 -88. ,585 1.00 48. 52 B c

ATOM 11961 CD PRO B 153 -76. 790 12. 718 -88. ,510 1.00 48. ,79 B c

ATOM 11964 C PRO B 153 -78. 893 13. 939 -90. ,716 1.00 47. ,42 B c

ATOM 11965 0 PRO B 153 -78. 991 14. 731 -89. ,769 1.00 48. 35 B 0

ATOM 11966 N ASP B 154 -79. 697 13. ,964 -91. ,778 1.00 45. ,83 B N

ATOM 11967 CA ASP B 154 -80. 826 14. 883 -91. ,835 1.00 44. ,80 B c

ATOM 11969 CB ASP B 154 -81. 108 15. 315 -93. 287 1.00 49. 25 B c

ATOM 11972 CG ASP B 154 -82. 199 16. 397 -93. 395 1.00 50. ,99 B c

ATOM 11973 ODl ASP B 154 -81. 966 17. 537 -92. 929 1.00 55. ,17 B 0

ATOM 11974 OD2 ASP B 154 -83. 283 16. 108 -93. ,966 1.00 46. ,51 B 0

ATOM 11975 C ASP B 154 -82. 038 14. ,219 -91. ,174 1.00 40. ,61 B c

ATOM 11976 0 ASP B 154 -82. 765 14. ,880 -90. ,427 1.00 37. ,13 B 0

ATOM 11978 N SER B 155 -82. 241 12. ,919 -91.425 1.00 41. ,53 B N

ATOM 11979 CA SER B 155 -83. 307 12. 150 -90. ,742 1.00 42. ,92 B c

ATOM 11981 CB SER B 155 -84. 191 11. ,404 -91.751 1.00 46. ,15 B c

ATOM 11984 OG SER B 155 -83. 450 10. ,418 -92. ,456 1.00 52. ,19 B 0

ATOM 11986 C SER B 155 -82. 777 11. 177 -89. ,648 1.00 43. ,65 B c

ATOM 11987 0 SER B 155 -81. 594 10. ,811 -89. ,616 1.00 41. ,62 B 0

ATOM 11989 N LEU B 156 -83. 686 10. 778 -88. ,758 1.00 42. ,02 B N

ATOM 11990 CA LEU B 156 -83. 351 9. 974 -87. ,578 1.00 43. ,01 B c

ATOM 11992 CB LEU B 156 -84. 564 9. 844 -86. ,647 1.00 45. ,42 B c

ATOM 11995 CG LEU B 156 -84. 272 9. 318 -85. 235 1.00 44. 68 B c

ATOM 11997 CDl LEU B 156 -83. 617 10. 393 -84. ,387 1.00 45. ,15 B c

ATOM 12001 CD2 LEU B 156 -85. ,547 8. ,818 -84. ,574 1.00 46. ,20 B c

ATOM 12005 C LEU B 156 -82. 850 8. ,589 -87. ,944 1.00 42. ,37 B c

ATOM 12006 0 LEU B 156 -83. 426 7. ,905 -88. ,800 1.00 38. ,46 B 0

ATOM 12008 N GLN B 157 -81. 776 8. 181 -87. ,270 1.00 44. ,21 B N

ATOM 12009 CA GLN B 157 -81. 138 6. 881 -87. ,498 1.00 44. ,83 B C

ATOM 12011 CB GLN B 157 -79. 666 7. 048 -87. ,887 1.00 47. ,81 B C

ATOM 12014 CG GLN B 157 -79. 441 8. 104 -88. ,978 1.00 53. ,12 B c

ATOM 12017 CD GLN B 157 -78. 661 7. ,610 -90. ,187 1.00 55. ,07 B c

ATOM 12018 OEl GLN B 157 -77. 961 6. 598 -90. ,139 1.00 58. ,56 B 0

ATOM 12019 NE2 GLN B 157 -78. 784 8. 339 -91. ,289 1.00 55. ,29 B N

ATOM 12022 C GLN B 157 -81. 275 6. 018 -86. ,249 1.00 42. ,99 B C human fD_Fab

ATOM 12023 O GLN B 157 -81. .669 6. ,509 -85. 182 1.00 42. ,15 B 0

ATOM 12025 N HIS B 158 -80. ,986 4. ,727 -86. 399 1.00 42. ,24 B N

ATOM 12026 CA HIS B 158 -81. .019 3. ,806 -85. ,271 1.00 45. ,10 B C

ATOM 12028 CB HIS B 158 -82. ,449 3. ,290 -85. 020 1.00 49. .81 B C

ATOM 12031 CG HIS B 158 -82. ,883 2. ,190 -85. 942 1.00 54. .85 B c

ATOM 12032 NDl HIS B 158 -83. ,287 2. ,418 -87. 241 1.00 56. .07 B N

ATOM 12034 CEl HIS B 158 -83. ,624 1. ,269 -87. 802 1.00 57. ,01 B c

ATOM 12036 NE2 HIS B 158 -83. ,461 0. 305 -86. 913 1.00 57. ,46 B N

ATOM 12038 CD2 HIS B 158 -83. ,003 0. ,854 -85. 740 1.00 57. 24 B c

ATOM 12040 C HIS B 158 -80. ,021 2. 655 -85. 434 1.00 45. 61 B c

ATOM 12041 O HIS B 158 -79. ,444 2. 463 -86. 511 1.00 46. ,12 B 0

ATOM 12043 N VAL B 159 -79. ,797 1. ,918 -84. ,346 1.00 43. ,34 B N

ATOM 12044 CA VAL B 159 -78. .960 0. ,725 -84. ,389 1.00 44. .38 B C

ATOM 12046 CB VAL B 159 -77. ,474 1. ,102 -84. 334 1.00 44. ,03 B C

ATOM 12048 CGI VAL B 159 -77. ,162 1. ,884 -83. 071 1.00 45. ,24 B C

ATOM 12052 CG2 VAL B 159 -76. 617 -0. ,135 -84. 428 1.00 46. ,69 B C

ATOM 12056 C VAL B 159 -79. ,309 -0. ,244 -83. 258 1.00 43. 23 B c

ATOM 12057 O VAL B 159 -79. 563 0. ,172 -82. 134 1.00 39. ,03 B 0

ATOM 12059 N LEU B 160 -79. 360 -1. ,537 -83. ,572 1.00 45. ,88 B N

ATOM 12060 CA LEU B 160 -79. 568 -2. ,565 -82. 546 1.00 47. ,19 B c

ATOM 12062 CB LEU B 160 -80. ,317 -3. 781 -83. 102 1.00 47. ,10 B c

ATOM 12065 CG LEU B 160 -81. ,770 -3. 929 -82. 647 1.00 48. ,50 B c

ATOM 12067 CDl LEU B 160 -82. 596 -2. 712 -83. 056 1.00 51. ,12 B c

ATOM 12071 CD2 LEU B 160 -82. 373 -5. 214 -83. 216 1.00 48. ,62 B c

ATOM 12075 C LEU B 160 -78. ,216 -2. 973 -81. 957 1.00 45. ,51 B c

ATOM 12076 O LEU B 160 -77. ,284 -3. 307 -82. 693 1.00 45. ,25 B 0

ATOM 12078 N LEU B 161 -78. ,118 -2. ,929 -80. ,630 1.00 43. ,05 B N

ATOM 12079 CA LEU B 161 -76. ,847 -3. ,128 -79. 937 1.00 43. ,33 B C

ATOM 12081 CB LEU B 161 -76. 320 -1. 797 -79. 370 1.00 40. ,66 B c

ATOM 12084 CG LEU B 161 -76. ,007 -0. 670 -80. 372 1.00 39. 23 B c

ATOM 12086 CDl LEU B 161 -75. ,485 0. 597 -79. 698 1.00 35. 33 B c

ATOM 12090 CD2 LEU B 161 -75. ,021 -1. ,134 -81. 426 1.00 41. ,94 B c

ATOM 12094 C LEU B 161 -77. ,040 -4. ,137 -78. ,815 1.00 43. ,38 B c

ATOM 12095 O LEU B 161 -78. ,004 -4. 039 -78. 060 1.00 44. ,08 B 0

ATOM 12097 N PRO B 162 -76. 134 -5. ,122 -78. 706 1.00 42. ,97 B N

ATOM 12098 CA PRO B 162 -76. 227 -6. 044 -77. 577 1.00 40. ,30 B c

ATOM 12100 CB PRO B 162 -75. 410 -7. ,252 -78. 043 1.00 42. ,85 B c

ATOM 12103 CG PRO B 162 -74. ,385 -6. 667 -78. 982 1.00 43. ,26 B c

ATOM 12106 CD PRO B 162 -74. ,999 -5. 433 -79. 596 1.00 42. ,14 B c

ATOM 12109 C PRO B 162 -75. ,636 -5. ,434 -76. 303 1.00 40. ,85 B c

ATOM 12110 0 PRO B 162 -74. ,555 -4. ,822 -76. 345 1.00 36. ,46 B 0

ATOM 12111 N VAL B 163 -76. ,356 -5. ,585 -75. 189 1.00 40. 16 B N

ATOM 12112 CA VAL B 163 -75. ,858 -5. ,159 -73. ,888 1.00 39. ,15 B c

ATOM 12114 CB VAL B 163 -76. ,860 -5. ,429 -72. ,758 1.00 39. ,42 B c

ATOM 12116 CGI VAL B 163 -76. ,280 -4. ,992 -71.401 1.00 35. ,30 B c

ATOM 12120 CG2 VAL B 163 -78. ,167 -4. ,704 -73. ,029 1.00 39. ,06 B c

ATOM 12124 C VAL B 163 -74. ,595 -5. ,924 -73. ,596 1.00 42. 05 B c

ATOM 12125 0 VAL B 163 -74. ,504 -7. ,120 -73. ,889 1.00 42. ,50 B 0

ATOM 12127 N LEU B 164 -73. ,611 -5. ,211 -73. ,045 1.00 41. 87 B N

ATOM 12128 CA LEU B 164 -72. ,334 -5. ,778 -72. ,648 1.00 37. 07 B c

ATOM 12130 CB LEU B 164 -71. ,194 -4. ,940 -73. ,221 1.00 36. ,93 B c

ATOM 12133 CG LEU B 164 -69. ,805 -5. ,511 -73. ,007 1.00 39. 92 B c

ATOM 12135 CDl LEU B 164 -69. ,614 -6. ,697 -73. ,952 1.00 42. ,50 B c

ATOM 12139 CD2 LEU B 164 -68. ,710 -4. ,443 -73. ,208 1.00 40. 56 B c

ATOM 12143 C LEU B 164 -72. .292 -5. ,755 -71. ,130 1.00 37. ,23 B c

ATOM 12144 0 LEU B 164 -72. .620 -4. ,734 -70. ,525 1.00 38. ,87 B 0

ATOM 12146 N ASP B 165 -71. .882 -6. ,868 -70. ,517 1.00 38. ,23 B N

ATOM 12147 CA ASP B 165 -71. ,871 -6. ,977 -69. ,050 1.00 34. ,02 B c

ATOM 12149 CB ASP B 165 -71. ,655 -8. ,412 -68. ,570 1.00 36. .03 B c

ATOM 12152 CG ASP B 165 -70. 252 -8. .923 -68. ,842 1.00 38. ,19 B c

ATOM 12153 ODl ASP B 165 -70. ,009 -9. ,394 -69. ,978 1.00 43. ,23 B 0

ATOM 12154 OD2 ASP B 165 -69. ,406 -8. ,881 -67. ,918 1.00 36. ,82 B 0

ATOM 12155 C ASP B 165 -70. ,842 -6. ,063 -68. ,410 1.00 32. ,69 B c

ATOM 12156 0 ASP B 165 -69. ,835 -5. ,723 -69. ,015 1.00 32. 25 B 0

ATOM 12158 N ARG B 166 -71. ,108 -5. ,686 -67. ,166 1.00 29. ,30 B N

ATOM 12159 CA ARG B 166 -70. ,377 -4. ,605 -66. ,513 1.00 30. 62 B c

ATOM 12161 CB ARG B 166 -71. ,082 -4. ,180 -65. ,219 1.00 30. ,40 B c

ATOM 12164 CG ARG B 166 -70. ,631 -2. ,810 -64. ,728 1.00 29. ,09 B c human fD_Fab

ATOM 12167 CD ARG B 166 -71. 502 -2. 282 -63. 605 1. 00 27. 01 B C

ATOM 12170 NE ARG B 166 -72. ,804 -1. 876 -64. ,113 1. 00 29. 92 B N

ATOM 12172 CZ ARG B 166 -73. 944 -2. 557 -63. ,947 1. 00 26. 47 B C

ATOM 12173 NHl ARG B 166 -73. 976 -3. 695 -63. ,266 1. 00 20. 42 B N

ATOM 12176 NH2 ARG B 166 -75. 066 -2. 083 -64. ,473 1. 00 24. 25 B N

ATOM 12179 C ARG B 166 -68. ,922 -4. 944 -66. .250 1. 00 32. 38 B C

ATOM 12180 O ARG B 166 -68. ,064 -4. 085 -66. 363 1. 00 33. 39 B 0

ATOM 12182 N ALA B 167 -68. 663 -6. 206 -65. ,933 1. 00 30. 31 B N

ATOM 12183 CA ALA B 167 -67. 320 -6. 674 -65. ,663 1. 00 29. 49 B C

ATOM 12185 CB ALA B 167 -67. ,355 -8. 078 -65. ,107 1. 00 26. 57 B C

ATOM 12189 C ALA B 167 -66. 424 -6. 583 -66. ,907 1. 00 30. 01 B C

ATOM 12190 O ALA B 167 -65. 313 -6. 035 -66. ,824 1. 00 35. 75 B 0

ATOM 12192 N THR B 168 -66. 896 -7. 090 -68. ,050 1. 00 30. 19 B N

ATOM 12193 CA THR B 168 -66. 171 -6. 890 -69. ,304 1. 00 32. 88 B C

ATOM 12195 CB THR B 168 -66. 893 -7. 539 -70. ,486 1. 00 33. 39 B C

ATOM 12197 OGl THR B 168 -67. ,160 -8. 911 -70. ,175 1. 00 38. 53 B 0

ATOM 12199 CG2 THR B 168 -66. 028 -7. 446 -71. ,746 1. 00 29. 37 B C

ATOM 12203 C THR B 168 -65. 985 -5. 396 -69. ,606 1. 00 35. 71 B C

ATOM 12204 O THR B 168 -64. 930 -4. 978 -70. ,062 1. 00 35. 55 B 0

ATOM 12206 N CYS B 169 -67. 024 -4. 605 -69. ,358 1. 00 36. 56 B N

ATOM 12207 CA CYS B 169 -66. 978 -3. 182 -69. ,645 1. 00 35. 15 B C

ATOM 12209 CB CYS B 169 -68. 378 -2. 581 -69. ,532 1. 00 29. 17 B C

ATOM 12212 SG CYS B 169 -68. 513 -1. 096 -70. ,505 1. 00 32. 36 B s

ATOM 12214 C CYS B 169 -65. 974 -2. 435 -68. ,744 1. 00 36. 04 B C

ATOM 12215 0 CYS B 169 -65. 404 -1. 421 -69. ,143 1. 00 35. 14 B 0

ATOM 12217 N ASN B 170 -65. 748 -2. 967 -67. ,549 1. 00 36. 17 B N

ATOM 12218 CA ASN B 170 -64. 801 -2. 405 -66. ,590 1. 00 35. 74 B c

ATOM 12220 CB ASN B 170 -65. 352 -2. 584 -65. ,164 1. 00 31.91 B c

ATOM 12223 CG ASN B 170 -66. 241 -1. 419 -64. ,733 1. 00 28. 26 B c

ATOM 12224 ODl ASN B 170 -66. 150 -0. 340 -65. 293 1. 00 27. 73 B 0

ATOM 12225 ND2 ASN B 170 -67. 082 -1. 632 -63. ,726 1. 00 23. 93 B N

ATOM 12228 C ASN B 170 -63. 356 -2. 945 -66. ,689 1. 00 37. 03 B c

ATOM 12229 0 ASN B 170 -62. 489 -2. 523 -65. ,918 1. 00 36. 38 B 0

ATOM 12231 N ARG B 171 -63. 078 -3. 829 -67. ,647 1. 00 33. 09 B N

ATOM 12232 CA ARG B 171 -61.693 -4. 221 -67. ,921 1. 00 35. 21 B c

ATOM 12234 CB ARG B 171 -61. 600 -5. 254 -69. ,034 1. 00 33. 47 B c

ATOM 12237 CG ARG B 171 -62. 351 -6. 543 -68. ,747 1. 00 33. 92 B c

ATOM 12240 CD ARG B 171 -61. 746 -7. 768 -69. 389 1. 00 36. 43 B c

ATOM 12243 NE ARG B 171 -60. 897 -7. 483 -70. 547 1. 00 37. 04 B N

ATOM 12245 CZ ARG B 171 -61. 125 -7. 865 -71. ,798 1. 00 40. 52 B c

ATOM 12246 NHl ARG B 171 -60. 245 -7. 545 -72. ,738 1. 00 43. 31 B N

ATOM 12249 NH2 ARG B 171 -62. 206 -8. 562 -72. ,129 1. 00 44. 51 B N

ATOM 12252 C ARG B 171 -60. ,871 -2. 991 -68. ,273 1. 00 35. 84 B c

ATOM 12253 0 ARG B 171 -61. 411 -1. 974 -68. ,715 1. 00 33. 94 B 0

ATOM 12255 N ARG B 172 -59. 566 -3. 087 -68. ,070 1. 00 35. 33 B N

ATOM 12256 CA ARG B 172 -58. ,676 -1. 943 -68. ,261 1. 00 34. 55 B C

ATOM 12258 CB ARG B 172 -57. 303 -2. 264 -67. ,668 1. 00 33. 46 B c

ATOM 12261 CG ARG B 172 -56. ,541 -3. 397 -68. ,347 1. 00 29. 86 B c

ATOM 12264 CD ARG B 172 -55. 317 -3. 712 -67. ,563 1. 00 30. 99 B c

ATOM 12267 NE ARG B 172 -55. 619 -4. 506 -66. ,377 1. 00 33. 73 B N

ATOM 12269 CZ ARG B 172 -54. 825 -4. 628 -65. ,318 1. 00 28. 79 B c

ATOM 12270 NHl ARG B 172 -53. 668 -3. 979 -65. ,246 1. 00 33. 93 B N

ATOM 12273 NH2 ARG B 172 -55. ,199 -5. 395 -64. ,313 1. 00 27. ,90 B N

ATOM 12276 C ARG B 172 -58. ,625 -1. 510 -69. ,729 1. 00 34. 80 B C

ATOM 12277 0 ARG B 172 -58. 479 -0. 333 -70. ,026 1. 00 32. 28 B 0

ATOM 12279 N THR B 173 -58. ,811 -2. 479 -70. ,620 1. 00 34. ,58 B N

ATOM 12280 CA THR B 173 -58. 883 -2. 293 -72. ,069 1. 00 32. ,42 B C

ATOM 12282 CB THR B 173 -59. ,075 -3. 679 -72. ,716 1. 00 29. ,64 B C

ATOM 12284 OGl THR B 173 -58. 385 -4. 666 -71.932 1. 00 30. ,92 B 0

ATOM 12286 CG2 THR B 173 -58. 582 -3. 717 -74. ,148 1. 00 24. ,42 B C

ATOM 12290 C THR B 173 -60. 044 -1. 417 -72. ,500 1. 00 36. 72 B C

ATOM 12291 0 THR B 173 -59. ,983 -0. ,763 -73. .543 1. 00 39. ,83 B 0

ATOM 12293 N HIS B 174 -61. ,086 -1. 422 -71, ,675 1. 00 38. ,61 B N

ATOM 12294 CA HIS B 174 -62. 339 -0. 734 -71. ,941 1. 00 34. ,67 B c

ATOM 12296 CB HIS B 174 -63. 501 -1. 735 -71. .806 1. 00 37. ,11 B c

ATOM 12299 CG HIS B 174 -63. ,311 -2. 970 -72, ,635 1. 00 34. 36 B c

ATOM 12300 NDl HIS B 174 -63. 763 -4. 210 -72, .245 1. 00 36. ,67 B N

ATOM 12302 CEl HIS B 174 -63. ,442 -5. 107 -73. .162 1. 00 36. ,45 B c human fD_Fab

ATOM 12304 NE2 HIS B 174 -62. .773 -4. 495 -74. 124 1.00 37. .93 B N

ATOM 12306 CD2 HIS B 174 -62. ,677 -3. 159 -73. 816 1.00 36. ,88 B C

ATOM 12308 C HIS B 174 -62. .464 0. 493 -71. 046 1.00 33. 22 B C

ATOM 12309 0 HIS B 174 -61.731 1. 450 -71. 273 1.00 38. ,91 B 0

ATOM 12311 N HIS B 175 -63. ,347 0. 487 -70. 042 1.00 36. 22 B N

ATOM 12312 CA HIS B 175 -63. 592 1. 705 -69. 223 1.00 34. ,60 B C

ATOM 12314 CB HIS B 175 -65. ,073 2. 038 -69. 202 1.00 31. ,00 B C

ATOM 12317 CG HIS B 175 -65. 608 2. 356 -70. 553 1.00 25. ,30 B c

ATOM 12318 NDl HIS B 175 -65. 108 3. 387 -71. 315 1.00 19. 59 B N

ATOM 12320 CEl HIS B 175 -65. ,731 3. 412 -72. 474 1.00 25. ,74 B C

ATOM 12322 NE2 HIS B 175 -66. 609 2. 423 -72. 496 1.00 27. ,94 B N

ATOM 12324 CD2 HIS B 175 -66. ,542 1. 743 -71.307 1.00 25. 09 B C

ATOM 12326 C HIS B 175 -63. ,025 1. 679 -67. 806 1.00 35. ,94 B C

ATOM 12327 O HIS B 175 -63. ,238 2. 617 -67. 010 1.00 30. ,61 B 0

ATOM 12329 N ASP B 176 -62. ,303 0. 598 -67. 514 1.00 35. ,25 B N

ATOM 12330 CA ASP B 176 -61. ,358 0. 550 -66. 407 1.00 36. ,94 B C

ATOM 12332 CB ASP B 176 -60. ,179 1. 447 -66. 760 1.00 33. ,23 B c

ATOM 12335 CG ASP B 176 -58. ,987 1. 238 -65. 863 1.00 34. ,84 B c

ATOM 12336 ODl ASP B 176 -58. ,915 0. 242 -65. 108 1.00 26. ,67 B 0

ATOM 12337 OD2 ASP B 176 -58. ,109 2. 108 -65. 924 1.00 36. ,62 B 0

ATOM 12338 C ASP B 176 -61. ,961 0. 937 -65. 035 1.00 38. ,13 B c

ATOM 12339 O ASP B 176 -61. ,390 1. 746 -64. 292 1.00 33. ,59 B 0

ATOM 12341 N GLY B 177 -63. ,101 0. 337 -64. 698 1.00 35. ,01 B N

ATOM 12342 CA GLY B 177 -63. 747 0. 562 -63. 404 1.00 33. 82 B c

ATOM 12345 C GLY B 177 -64. 709 1. 746 -63. 345 1.00 34. 35 B c

ATOM 12346 O GLY B 177 -65. 380 1. 969 -62. 335 1.00 35. 17 B 0

ATOM 12348 N ALA B 178 -64. ,791 2. 504 -64. 439 1.00 34. ,01 B N

ATOM 12349 CA ALA B 178 -65. ,620 3. 705 -64. 484 1.00 33. ,05 B c

ATOM 12351 CB ALA B 178 -65. 215 4. 573 -65. 645 1.00 26. ,36 B c

ATOM 12355 C ALA B 178 -67. ,125 3. 403 -64. 562 1.00 34. ,79 B c

ATOM 12356 O ALA B 178 -67. ,948 4. 294 -64. 348 1.00 34. ,67 B 0

ATOM 12358 N ILE B 179 -67. ,470 2. 152 -64. 873 1.00 34. ,11 B N

ATOM 12359 CA ILE B 179 -68. ,863 1. 748 -65. 050 1.00 33. ,19 B c

ATOM 12361 CB ILE B 179 -69. 059 0. 654 -66. 173 1.00 29. ,54 B c

ATOM 12363 CGI ILE B 179 -68. 203 0. 952 -67. 420 1.00 27. ,31 B c

ATOM 12366 CDl ILE B 179 -68. 634 2. 192 -68. 236 1.00 20. ,12 B c

ATOM 12370 CG2 ILE B 179 -70. 539 0. 538 -66. 562 1.00 20. ,08 B c

ATOM 12374 C ILE B 179 -69. 457 1. 288 -63. 707 1.00 31. ,94 B c

ATOM 12375 O ILE B 179 -69. 128 0. 226 -63. 187 1.00 30. ,77 B 0

ATOM 12377 N THR B 180 -70. 314 2. 139 -63. 153 1.00 31.52 B N

ATOM 12378 CA THR B 180 -70. ,964 1. 894 -61. 871 1.00 35. ,50 B C

ATOM 12380 CB THR B 180 -71. 390 3. 219 -61. 160 1.00 32. 61 B C

ATOM 12382 OGl THR B 180 -72. 426 3. 853 -61. 920 1.00 35. ,70 B 0

ATOM 12384 CG2 THR B 180 -70. 196 4. 198 -60. 944 1.00 26. 05 B C

ATOM 12388 C THR B 180 -72. 234 1. 067 -62. 054 1.00 40. 34 B c

ATOM 12389 O THR B 180 -72. ,652 0. 754 -63. 183 1.00 38. 49 B 0

ATOM 12391 N GLU B 181 -72. 883 0. 759 -60. 944 1.00 42. 21 B N

ATOM 12392 CA GLU B 181 -74. 161 0. 066 -61. 004 1.00 45. 87 B c

ATOM 12394 CB GLU B 181 -74. 551 -0. 452 -59. 619 1.00 48. 59 B c

ATOM 12397 CG GLU B 181 -73. 815 -1. 751 -59. 260 1.00 56. 25 B c

ATOM 12400 CD GLU B 181 -74. 201 -2. 332 -57. 893 1.00 58. ,77 B c

ATOM 12401 OEl GLU B 181 -73. 776 -1. 754 -56. 857 1.00 58. 59 B 0

ATOM 12402 OE2 GLU B 181 -74. 905 -3. 383 -57. 868 1.00 61. 60 B 0

ATOM 12403 C GLU B 181 -75. 289 0. 902 -61. 634 1.00 42. ,30 B c

ATOM 12404 O GLU B 181 -76. 330 0. 350 -61. 965 1.00 39. .41 B 0

ATOM 12406 N ARG B 182 -75. 062 2. 200 -61. 858 1.00 41. ,47 B N

ATOM 12407 CA ARG B 182 -76. ,084 3. 091 -62. 431 1.00 42. .72 B c

ATOM 12409 CB ARG B 182 -76. 196 4. 405 -61. 633 1.00 43. 22 B c

ATOM 12412 CG ARG B 182 -75. ,718 4. 301 -60. 199 1.00 47. ,49 B c

ATOM 12415 CD ARG B 182 -76. 538 5. 084 -59. 184 1.00 54. .41 B c

ATOM 12418 NE ARG B 182 -76. ,541 4. 375 -57. 893 1.00 61. .75 B N

ATOM 12420 CZ ARG B 182 -75. 492 4. 257 -57. 061 1.00 63. ,81 B c

ATOM 12421 NHl ARG B 182 -74. 309 4. 810 -57. 342 1.00 63. .67 B N

ATOM 12424 NH2 ARG B 182 -75. 622 3. 575 -55. 922 1.00 62. 00 B N

ATOM 12427 C ARG B 182 -75. 800 3. 401 -63. 897 1.00 35. ,89 B C

ATOM 12428 O ARG B 182 -76. 465 4. 234 -64. 499 1.00 36. ,81 B 0

ATOM 12430 N LEU B 183 -74. 784 2. 745 -64. 450 1.00 35. ,25 B N

ATOM 12431 CA LEU B 183 -74. ,434 2. 866 -65. .861 1.00 37. ,01 B C human fD_Fab

ATOM 12433 CB LEU B 183 -72 .997 3. ,407 -66, .035 1.00 31, .27 B C

ATOM 12436 CG LEU B 183 -72, .694 4. ,858 -65, .628 1.00 29, .14 B C

ATOM 12438 CDl LEU B 183 -71, .184 5. ,119 -65, .671 1.00 28, .88 B c

ATOM 12442 CD2 LEU B 183 -73. .426 5. ,859 -66, .510 1.00 24, .19 B C

ATOM 12446 C LEU B 183 -74, .525 1. ,468 -66, .453 1.00 35, .75 B C

ATOM 12447 O LEU B 183 -74, .328 0. ,489 -65, .745 1.00 38, .90 B 0

ATOM 12449 N MET B 184 -74, .832 1. ,382 -67, .739 1.00 35, .46 B N

ATOM 12450 CA MET B 184 -74, .805 0. ,115 -68, .457 1.00 36, .84 B c

ATOM 12452 CB MET B 184 -76, .225 -0. ,394 -68. ,745 1.00 36, .86 B c

ATOM 12455 CG MET B 184 -77, ,106 0. 569 -69, .526 1.00 35, .89 B c

ATOM 12458 SD MET B 184 -78. ,784 -0. ,044 -69. ,803 1.00 36, .03 B S

ATOM 12459 CE MET B 184 -78. ,511 -1. ,456 -70. .877 1.00 33, .32 B c

ATOM 12463 C MET B 184 -74, ,020 0. ,308 -69. ,741 1.00 32, .53 B c

ATOM 12464 O MET B 184 -73. .827 1. 423 -70. .194 1.00 32. .30 B 0

ATOM 12466 N CYS B 185 -73. ,568 -0. 791 -70. ,316 1.00 33. .26 B N

ATOM 12467 CA CYS B 185 -72. ,748 -0. 748 -71. ,518 1.00 36. ,64 B c

ATOM 12469 CB CYS B 185 -71.367 -1. 357 -71. ,235 1.00 38. .17 B c

ATOM 12472 SG CYS B 185 -70. ,348 -0. 403 -70. ,093 1.00 36. ,22 B S

ATOM 12474 C CYS B 185 -73. ,400 -1. 505 -72. ,666 1.00 35. ,20 B c

ATOM 12475 O CYS B 185 -74. ,161 -2. 452 -72. ,447 1.00 35. ,95 B 0

ATOM 12477 N ALA B 186 -73. ,100 -1. 069 -73. ,885 1.00 34. ,74 B N

ATOM 12478 CA ALA B 186 -73. .452 -1. 821 -75. ,083 1.00 37. ,51 B c

ATOM 12480 CB ALA B 186 -74. ,584 -1. 148 -75. ,844 1.00 38. ,12 B c

ATOM 12484 C ALA B 186 -72. ,216 -1. 936 -75. ,961 1.00 40. ,78 B c

ATOM 12485 O ALA B 186 -71. ,304 -1. 117 -75. ,875 1.00 43. ,21 B 0

ATOM 12487 N GLU B 187 -72. ,182 -2. 964 -76. ,800 1.00 41. ,62 B N

ATOM 12488 CA GLU B 187 -71.062 -3. 155 -77. ,712 1.00 44. ,40 B c

ATOM 12490 CB GLU B 187 -71. ,150 -4. 506 -78. ,442 1.00 47. ,65 B c

ATOM 12493 CG GLU B 187 -70. 680 -5. 694 -77. ,577 1.00 50. ,81 B c

ATOM 12496 CD GLU B 187 -70. ,902 -7. 060 -78. 223 1.00 51. ,21 B c

ATOM 12497 OEl GLU B 187 -70. ,622 -7. 203 -79. ,437 1.00 55. ,99 B 0

ATOM 12498 OE2 GLU B 187 -71. ,355 -7. 990 -77. ,508 1.00 49. ,28 B 0

ATOM 12499 C GLU B 187 -70. ,961 -1. 997 -78. ,698 1.00 43. ,03 B c

ATOM 12500 O GLU B 187 -71. 956 -1. 332 -79. ,015 1.00 39. ,30 B 0

ATOM 12502 N SER B 188 -69. 748 -1. 758 -79. ,173 1.00 43. ,50 B N

ATOM 12503 CA SER B 188 -69. ,471 -0. 595 -79. ,987 1.00 43. ,24 B c

ATOM 12505 CB SER B 188 -68. 762 0. 458 -79. ,137 1.00 37. ,43 B c

ATOM 12508 OG SER B 188 -67. 499 -0. 013 -78. ,729 1.00 35. ,54 B 0

ATOM 12510 C SER B 188 -68. 637 -0. 904 -81. ,228 1.00 45. ,04 B c

ATOM 12511 O SER B 188 -68. 133 0. 022 -81. ,852 1.00 47. ,84 B 0

ATOM 12513 N ASN B 189 -68. 488 -2. 176 -81. ,604 1.00 47. ,53 B N

ATOM 12514 CA ASN B 189 -67. 661 -2. 522 -82. ,766 1.00 49. ,22 B c

ATOM 12516 CB ASN B 189 -67. 366 -4. 026 -82. ,827 1.00 47. ,70 B c

ATOM 12519 CG ASN B 189 -66. 282 -4. 376 -83. ,852 1.00 47. 91 B c

ATOM 12520 ODl ASN B 189 -65. 480 -3. 533 -84. ,260 1.00 44. ,43 B 0

ATOM 12521 ND2 ASN B 189 -66. 257 -5. 632 -84. ,262 1.00 53. ,53 B N

ATOM 12524 C ASN B 189 -68. 309 -2. 044 -84. ,071 1.00 49. ,58 B c

ATOM 12525 O ASN B 189 -69. 210 -2. 697 -84. ,610 1.00 45. ,38 B 0

ATOM 12527 N ARG B 190 -67. 854 -0. 878 -84. ,539 1.00 51. 66 B N

ATOM 12528 CA ARG B 190 -68. 330 -0. 238 -85. ,781 1.00 58. ,55 B c

ATOM 12530 CB ARG B 190 -67. 776 -0. 979 -87. ,000 1.00 64. ,58 B c

ATOM 12533 CG ARG B 190 -66. 236 -1. 136 -86. ,973 1.00 68. ,80 B c

ATOM 12536 CD ARG B 190 -65. 720 -2. 046 -88. ,090 1.00 70. ,00 B c

ATOM 12539 NE ARG B 190 -66. 510 -3. 277 -88. ,216 1.00 73. 59 B N

ATOM 12541 cz ARG B 190 -66. 270 -4. 241 -89. ,104 1.00 73. ,84 B c

ATOM 12542 NHl ARG B 190 -65. 239 -4. 148 -89. ,944 1.00 75. ,21 B N

ATOM 12545 NH2 ARG B 190 -67. 059 -5. 316 -89. ,139 1.00 72. ,16 B N

ATOM 12548 C ARG B 190 -69. 867 -0. 043 -85. ,867 1.00 56. ,85 B C

ATOM 12549 O ARG B 190 -70. 430 0. 141 -86. ,948 1.00 56. 83 B 0

ATOM 12551 N ARG B 191 -70. 515 -0. 070 -84. ,705 1.00 55. ,94 B N

ATOM 12552 CA ARG B 191 -71. 942 0. 179 -84. 555 1.00 56. 94 B c

ATOM 12554 CB ARG B 191 -72. 722 -1. 131 -84. 599 1.00 63. 10 B c

ATOM 12557 CG ARG B 191 -72. 895 -1. 741 -85. 984 1.00 68. ,85 B c

ATOM 12560 CD ARG B 191 -72. 805 -3. 252 -85. 899 1.00 73. ,46 B c

ATOM 12563 NE ARG B 191 -73. 602 -3. 933 -86. 913 1.00 78. 73 B N

ATOM 12565 CZ ARG B 191 -73. 714 -5. 258 -87. 007 1.00 80. 89 B c

ATOM 12566 NHl ARG B 191 -73. 074 -6. 058 -86. 150 1.00 80. ,31 B N

ATOM 12569 NH2 ARG B 191 -74. 469 -5. 790 -87. 965 1.00 80. 66 B N human fD_Fab

ATOM 12572 C ARG B 191 -72. .101 0. ,804 -83. ,178 1. 00 51.03 B C

ATOM 12573 0 ARG B 191 -71. ,781 0. 154 -82. ,179 1. 00 53.18 B 0

ATOM 12575 N ASP B 192 -72. ,573 2. 046 -83. 095 1. 00 45.22 B N

ATOM 12576 CA ASP B 192 -72. ,477 2. 760 -81. 823 1. 00 44.57 B C

ATOM 12578 CB ASP B 192 -70. 997 3. 124 -81.584 1. 00 43.63 B c

ATOM 12581 CG ASP B 192 -70. ,655 3. 415 -80. 108 1. 00 43.13 B c

ATOM 12582 ODl ASP B 192 -71. ,399 3. 023 -79. 157 1. 00 35.38 B 0

ATOM 12583 0D2 ASP B 192 -69. ,586 4. 043 -79. ,925 1. 00 42.83 B 0

ATOM 12584 C ASP B 192 -73. ,338 4. 024 -81. 708 1. 00 41.14 B c

ATOM 12585 0 ASP B 192 -73. ,794 4. 595 -82. 715 1. 00 38.25 B 0

ATOM 12587 N SER B 193 -73. ,568 4. 416 -80. ,451 1. 00 41.64 B N

ATOM 12588 CA SER B 193 -73. ,946 5. 786 -80. 082 1. 00 44.01 B c

ATOM 12590 CB SER B 193 -74. ,255 5. 908 -78. ,581 1. 00 46.21 B c

ATOM 12593 OG SER B 193 -75. ,577 5. 501 -78. 287 1. 00 50.05 B 0

ATOM 12595 C SER B 193 -72. ,771 6. 682 -80. 380 1. 00 47.25 B c

ATOM 12596 0 SER B 193 -71. ,624 6. 248 -80. 374 1. 00 47.84 B 0

ATOM 12598 N CYS B 194 -73. ,037 7. 952 -80. 596 1. 00 52.09 B N

ATOM 12599 CA CYS B 194 -72. ,009 8. 805 -81.132 1. 00 54.41 B c

ATOM 12601 CB CYS B 194 -71. ,965 8. 594 -82. 646 1. 00 58.20 B c

ATOM 12604 SG CYS B 194 -70. ,337 8. 642 -83. 371 1. 00 60.60 B s

ATOM 12606 C CYS B 194 -72. ,296 10. 259 -80. ,772 1. 00 53.73 B c

ATOM 12607 0 CYS B 194 -73. ,331 10. 563 -80. ,179 1. 00 53.47 B 0

ATOM 12609 N LYS B 195 -71.373 11. ,146 -81. ,128 1. 00 54.45 B N

ATOM 12610 CA LYS B 195 -71. ,512 12. 573 -80. 853 1. 00 51.86 B c

ATOM 12612 CB LYS B 195 -70. ,304 13. 338 -81. ,417 1. 00 53.44 B c

ATOM 12615 CG LYS B 195 -70. ,128 14. 760 -80. 867 1. 00 56.86 B c

ATOM 12618 CD LYS B 195 -68. ,651 15. 092 -80. 586 1. 00 59.99 B c

ATOM 12621 CE LYS B 195 -68. ,206 14. 729 -79. 134 1. 00 64.78 B c

ATOM 12624 NZ LYS B 195 -68. ,449 13. 303 -78. 703 1. 00 65.86 B N

ATOM 12628 C LYS B 195 -72. ,829 13. 120 -81. 432 1. 00 46.35 B C

ATOM 12629 0 LYS B 195 -73. 071 13. 051 -82. 636 1. 00 42.38 B 0

ATOM 12631 N GLY B 196 -73. ,684 13. 651 -80. 564 1. 00 41.90 B N

ATOM 12632 CA GLY B 196 -74. 995 14. 128 -80. 979 1. 00 38.15 B c

ATOM 12635 C GLY B 196 -76. ,130 13. 172 -80. ,663 1. 00 35.92 B c

ATOM 12636 0 GLY B 196 -77. ,305 13. ,543 -80. ,828 1. 00 34.70 B 0

ATOM 12638 N ASP B 197 -75. ,802 11. 955 -80. ,214 1. 00 32.69 B N

ATOM 12639 CA ASP B 197 -76. ,820 10. 978 -79. ,787 1. 00 35.79 B c

ATOM 12641 CB ASP B 197 -76. 453 9. 571 -80. ,256 1. 00 39.54 B c

ATOM 12644 CG ASP B 197 -76. 266 9. 480 -81. ,776 1. 00 42.63 B c

ATOM 12645 ODl ASP B 197 -77. 212 9. 823 -82. ,515 1. 00 40.35 B 0

ATOM 12646 OD2 ASP B 197 -75. 175 9. 057 -82. ,230 1. 00 43.94 B 0

ATOM 12647 C ASP B 197 -77. ,051 11. 018 -78. ,261 1. 00 32.06 B c

ATOM 12648 0 ASP B 197 -78. 002 10. 419 -77. 759 1. 00 31.68 B 0

ATOM 12650 N SER B 198 -76. ,204 11. 753 -77. ,543 1. 00 31.56 B N

ATOM 12651 CA SER B 198 -76. ,363 11.980 -76. 096 1. 00 34.61 B c

ATOM 12653 CB SER B 198 -75. ,455 13. 115 -75. ,637 1. 00 33.79 B c

ATOM 12656 OG SER B 198 -74. ,147 12. ,957 -76. ,139 1. 00 41.73 B 0

ATOM 12658 C SER B 198 -77. ,777 12. ,376 -75. ,728 1. 00 34.86 B c

ATOM 12659 0 SER B 198 -78. ,417 13. ,126 -76. ,454 1. 00 36.24 B 0

ATOM 12661 N GLY B 199 -78. 261 11. ,893 -74. ,591 1. 00 37.18 B N

ATOM 12662 CA GLY B 199 -79. ,613 12. ,207 -74. ,147 1. 00 36.50 B c

ATOM 12665 C GLY B 199 -80. ,656 11. ,287 -74. ,738 1. 00 34.86 B c

ATOM 12666 0 GLY B 199 -81.738 11. ,146 -74. ,173 1. 00 33.48 B 0

ATOM 12668 N GLY B 200 -80. 339 10. 653 -75. ,866 1. 00 36.89 B N

ATOM 12669 CA GLY B 200 -81. 287 9. ,800 -76. ,578 1. 00 35.23 B c

ATOM 12672 C GLY B 200 -81. ,527 8. ,471 -75. ,884 1. 00 38.06 B c

ATOM 12673 0 GLY B 200 -80. ,829 8. ,142 -74. ,924 1. 00 38.35 B 0

ATOM 12675 N PRO B 201 -82. ,503 7. ,685 -76. ,382 1. 00 39.31 B N

ATOM 12676 CA PRO B 201 -82. ,981 6. ,468 -75. ,732 1. 00 37.22 B c

ATOM 12678 CB PRO B 201 -84. ,413 6. ,379 -76. ,227 1. 00 38.30 B c

ATOM 12681 CG PRO B 201 -84. ,343 6. ,919 -77. ,609 1. 00 39.39 B c

ATOM 12684 CD PRO B 201 -83. ,224 7. ,925 -77. ,645 1. 00 38.86 B c

ATOM 12687 C PRO B 201 -82. ,245 5. ,171 -76. ,117 1. 00 33.96 B c

ATOM 12688 0 PRO B 201 -81.924 4. 956 -77. ,286 1. 00 31.96 B 0

ATOM 12689 N LEU B 202 -81. 958 4. 343 -75. ,115 1. 00 32.44 B N

ATOM 12690 CA LEU B 202 -81. ,652 2. 942 -75. .330 1. 00 34.89 B c

ATOM 12692 CB LEU B 202 -80. ,398 2. ,502 -74. ,568 1. 00 33.21 B c

ATOM 12695 CG LEU B 202 -79. ,889 1. ,081 -74. ,836 1. 00 31.27 B c human fD_Fab

ATOM 12697 CDl LEU B 202 -79. ,192 0. 991 -76. 188 1.00 29. ,13 B C

ATOM 12701 CD2 LEU B 202 -78. ,956 0. 639 -73. 727 1.00 32. 36 B C

ATOM 12705 C LEU B 202 -82. 880 2. 174 -74. 860 1.00 34. ,34 B C

ATOM 12706 O LEU B 202 -83. 219 2. 188 -73. 673 1.00 31. ,58 B 0

ATOM 12708 N VAL B 203 -83. 541 1. 513 -75. 810 1.00 38. ,47 B N

ATOM 12709 CA VAL B 203 -84. 815 0. 853 -75. 585 1.00 37. 22 B C

ATOM 12711 CB VAL B 203 -85. 822 1. 299 -76. 667 1.00 36. 35 B C

ATOM 12713 CGI VAL B 203 -87. 144 0. 508 -76. 577 1.00 31. 97 B C

ATOM 12717 CG2 VAL B 203 -86. 048 2. 798 -76. ,581 1.00 32. ,51 B c

ATOM 12721 C VAL B 203 -84. 609 -0. 650 -75. 685 1.00 38. ,44 B c

ATOM 12722 O VAL B 203 -84. 228 -1. 142 -76. 753 1.00 39. 33 B 0

ATOM 12724 N CYS B 204 -84. 843 -1. 371 -74. 586 1.00 41. ,39 B N

ATOM 12725 CA CYS B 204 -84. 751 -2. 841 -74. 586 1.00 45. 36 B c

ATOM 12727 CB CYS B 204 -83. 666 -3. 353 -73. 620 1.00 45. ,09 B c

ATOM 12730 SG CYS B 204 -82. 105 -2. 433 -73. 624 1.00 39. ,44 B S

ATOM 12732 C CYS B 204 -86. 090 -3. 479 -74. 223 1.00 48. 72 B c

ATOM 12733 O CYS B 204 -86. 550 -3. 363 -73. 073 1.00 48. ,17 B 0

ATOM 12735 N GLY B 205 -86. 687 -4. 160 -75. 210 1.00 50. 48 B N

ATOM 12736 CA GLY B 205 -87. 989 -4. 807 -75. 065 1.00 51. 77 B c

ATOM 12739 C GLY B 205 -89. 138 -3. 824 -74. 940 1.00 53. 16 B c

ATOM 12740 O GLY B 205 -90. 004 -3. 980 -74. 067 1.00 51. 62 B 0

ATOM 12742 N GLY B 206 -89. 130 -2. 799 -75. ,794 1.00 53. ,35 B N

ATOM 12743 CA GLY B 206 -90. 185 -1. 776 -75. 794 1.00 51. 89 B c

ATOM 12746 C GLY B 206 -90. 209 -0. 785 -74. 633 1.00 51. ,08 B C

ATOM 12747 O GLY B 206 -91. 023 0. 148 -74. 649 1.00 49. ,75 B 0

ATOM 12749 N VAL B 207 -89. 334 -0. 974 -73. 639 1.00 50. ,58 B N

ATOM 12750 CA VAL B 207 -89. 191 -0. 052 -72. 501 1.00 48. ,25 B C

ATOM 12752 CB VAL B 207 -89. 258 -0. 812 -71. 153 1.00 49. ,39 B c

ATOM 12754 CGI VAL B 207 -89. 030 0. 141 -69. 974 1.00 46. ,80 B c

ATOM 12758 CG2 VAL B 207 -90. 589 -1. 540 -71. 017 1.00 48. ,67 B c

ATOM 12762 C VAL B 207 -87. 853 0. 687 -72. 584 1.00 45. ,96 B c

ATOM 12763 O VAL B 207 -86. 867 0. 116 -73. 031 1.00 44. ,17 B 0

ATOM 12765 N LEU B 208 -87. 842 1. 954 -72. 164 1.00 42. 89 B N

ATOM 12766 CA LEU B 208 -86. 608 2. 738 -72. ,004 1.00 41. ,47 B c

ATOM 12768 CB LEU B 208 -86. 940 4. 203 -71. ,727 1.00 39. ,60 B C

ATOM 12771 CG LEU B 208 -85. 789 5. 202 -71. ,618 1.00 38. ,74 B C

ATOM 12773 CDl LEU B 208 -85. 295 5. 668 -72. 982 1.00 36. ,12 B C

ATOM 12777 CD2 LEU B 208 -86. 246 6. 386 -70. ,793 1.00 40. ,17 B c

ATOM 12781 C LEU B 208 -85. 796 2. 179 -70. ,840 1.00 43. ,99 B c

ATOM 12782 O LEU B 208 -86. 299 2. 073 -69. 716 1.00 46. ,50 B 0

ATOM 12784 N GLU B 209 -84. 544 1. 818 -71.119 1.00 41.65 B N

ATOM 12785 CA GLU B 209 -83. 639 1. 279 -70. 105 1.00 39. ,77 B c

ATOM 12787 CB GLU B 209 -83. 127 -0. 095 -70. 544 1.00 41. ,67 B c

ATOM 12790 CG GLU B 209 -84. 181 -1. 205 -70. 491 1.00 43. ,10 B c

ATOM 12793 CD GLU B 209 -84. 478 -1. 705 -69. 082 1.00 43. ,79 B c

ATOM 12794 OEl GLU B 209 -83. 726 -1. 385 -68. ,141 1.00 38. .71 B 0

ATOM 12795 OE2 GLU B 209 -85. 470 -2. 444 -68. ,919 1.00 49. ,82 B 0

ATOM 12796 C GLU B 209 -82. 455 2. 206 -69. ,808 1.00 39. ,44 B c

ATOM 12797 O GLU B 209 -81. 933 2. 203 -68. ,689 1.00 37. ,61 B 0

ATOM 12799 N GLY B 210 -82. 033 2. 976 -70. ,807 1.00 38. ,68 B N

ATOM 12800 CA GLY B 210 -80. 891 3. 860 -70. ,663 1.00 38. ,23 B c

ATOM 12803 C GLY B 210 -80. 969 5. 120 -71. ,501 1.00 35. ,44 B c

ATOM 12804 O GLY B 210 -81. 697 5. 190 -72. ,494 1.00 35. ,18 B 0

ATOM 12806 N VAL B 211 -80. 214 6. 123 -71. ,066 1.00 36. ,90 B N

ATOM 12807 CA VAL B 211 -80. 085 7. 396 -71. ,766 1.00 35. ,87 B c

ATOM 12809 CB VAL B 211 -80. 488 8. 624 -70. ,867 1.00 31. ,92 B c

ATOM 12811 CGI VAL B 211 -80. 375 9. 929 -71. 633 1.00 26. ,28 B c

ATOM 12815 CG2 VAL B 211 -81. 921 8. 463 -70. ,311 1.00 27. .99 B c

ATOM 12819 C VAL B 211 -78. ,627 7. 468 -72. ,200 1.00 34. .38 B c

ATOM 12820 O VAL B 211 -77. ,718 7. 281 -71. ,390 1.00 31. .06 B 0

ATOM 12822 N VAL B 212 -78. 410 7. 677 -73. ,492 1.00 36. .38 B N

ATOM 12823 CA VAL B 212 -77. 068 7. 769 -74. ,018 1.00 41. .41 B c

ATOM 12825 CB VAL B 212 -77. 051 8. 196 -75. ,506 1.00 37. ,24 B c

ATOM 12827 CGI VAL B 212 -75. 629 8. 415 -75. ,977 1.00 36. ,89 B c

ATOM 12831 CG2 VAL B 212 -77. 749 7. 155 -76. ,368 1.00 33. ,32 B c

ATOM 12835 C VAL B 212 -76. 352 8. 789 -73. ,169 1.00 46. ,37 B c

ATOM 12836 0 VAL B 212 -76. 777 9. 948 -73. ,095 1.00 43. ,48 B 0

ATOM 12838 N TH B 213 -75. 299 8. 337 -72. ,486 1.00 55. ,38 B N human fD_Fab

ATOM 12839 CA THR B 213 -74. 458 9. 227 -71. ,700 1. 00 61. 39 B C

ATOM 12841 CB THR B 213 -73. 608 8. 469 -70. ,652 1. 00 58. 03 B C

ATOM 12843 OGl THR B 213 -74. 434 7. 548 -69. ,938 1. 00 57. 21 B 0

ATOM 12845 CG2 THR B 213 -72. 980 9. 452 -69. ,670 1. 00 57. 86 B C

ATOM 12849 C THR B 213 -73. 613 9. 920 -72. ,739 1. 00 68. 39 B C

ATOM 12850 O THR B 213 -74. ,175 10. 569 -73. ,624 1.00 73. ,70 B 0

ATOM 12852 N SER B 214 -72. 293 9. 784 -72. ,693 1. 00 72. ,34 B N

ATOM 12853 CA SER B 214 -71.483 10. 490 -73. ,655 1.00 76. ,63 B C

ATOM 12855 CB SER B 214 -72. 244 11. 782 -74. 120 1.00 82. 45 B C

ATOM 12858 OG SER B 214 -71.557 12. 491 -75. ,146 1.00 86. 44 B 0

ATOM 12860 C SER B 214 -70. 196 11. 003 -73. 065 1. 00 80. 05 B c

ATOM 12861 O SER B 214 -69. 688 10. 526 -72. 048 1.00 82. 25 B 0

ATOM 12863 N GLY B 215 -69. 711 12. 035 -73. 739 1. 00 77. 92 B N

ATOM 12864 CA GLY B 215 -68. 498 12. 706 -73. 383 1. 00 76. 82 B c

ATOM 12867 C GLY B 215 -67. 669 12. 774 -74. 638 1. 00 75. 08 B c

ATOM 12868 O GLY B 215 -68. 188 12. 971 -75. ,748 1. 00 77. 37 B 0

ATOM 12870 N SER B 216 -66. 373 12. 584 -74. ,457 1.00 72. 90 B N

ATOM 12871 CA SER B 216 -65. 425 12. 634 -75. ,553 1.00 70. 77 B c

ATOM 12873 CB SER B 216 -64. 291 13. 622 -75. ,219 1.00 73. 92 B c

ATOM 12876 OG SER B 216 -64. 763 14. 969 -75. ,215 1. 00 74. 90 B 0

ATOM 12878 C SER B 216 -64. 890 11. 223 -75. ,808 1.00 68. 84 B C

ATOM 12879 O SER B 216 -63. 722 11. 039 -76. ,167 1. 00 69. 50 B 0

ATOM 12881 N ARG B 217 -65. 754 10. 227 -75. ,615 1.00 65. 27 B N

ATOM 12882 CA ARG B 217 -65. 435 8. 852 -75. ,959 1. 00 63. 16 B C

ATOM 12884 CB ARG B 217 -66. 431 7. 887 -75. 295 1. 00 63. 89 B C

ATOM 12887 CG ARG B 217 -66. 066 6. 399 -75. ,421 1. 00 62. 52 B c

ATOM 12890 CD ARG B 217 -67. 191 5. 462 -74. ,945 1.00 60. 25 B c

ATOM 12893 NE ARG B 217 -68. 497 5. 742 -75. ,562 1.00 58. ,67 B N

ATOM 12895 CZ ARG B 217 -68. 845 5. 448 -76. ,817 1.00 55. 55 B c

ATOM 12896 NHl ARG B 217 -67. 991 4. 862 -77. ,648 1.00 52. 91 B N

ATOM 12899 NH2 ARG B 217 -70. 066 5. 752 -77. ,247 1.00 57. 97 B N

ATOM 12902 C ARG B 217 -65. 472 8. 709 -77. ,482 1.00 60. 60 B c

ATOM 12903 0 ARG B 217 -66. 413 9. 166 -78. ,136 1. 00 56. 15 B 0

ATOM 12905 N VAL B 218 -64. 435 8. 087 -78. ,036 1.00 61.06 B N

ATOM 12906 CA VAL B 218 -64. 349 7. 836 -79. ,476 1. 00 60. 42 B c

ATOM 12908 CB VAL B 218 -62. 934 7. 291 -79. ,876 1.00 65. 50 B c

ATOM 12910 CGl VAL B 218 -62. 784 7. 218 -81. ,410 1. 00 68. 16 B c

ATOM 12914 CG2 VAL B 218 -62. 646 5. 925 -79. ,216 1.00 64. 49 B c

ATOM 12918 C VAL B 218 -65. 463 6. 870 -79, ,915 1.00 59. 72 B c

ATOM 12919 0 VAL B 218 -65. 848 5. 961 -79. ,169 1.00 60. ,55 B 0

ATOM 12921 N CYS B 219 -65. 962 7. 076 -81, ,130 1. 00 54. 52 B N

ATOM 12922 CA CYS B 219 -67. 122 6. 357 -81. ,644 1.00 53. 57 B c

ATOM 12924 CB CYS B 219 -67. 877 7. 308 -82, ,569 1. 00 55. 06 B c

ATOM 12927 SG CYS B 219 -69. 526 6. 823 -83. ,034 1.00 52. 70 B s

ATOM 12929 C CYS B 219 -66. 726 5. 099 -82. ,427 1.00 49. 52 B c

ATOM 12930 0 CYS B 219 -65. 750 5. 115 -83. ,172 1.00 48. 13 B 0

ATOM 12932 N GLY B 220 -67. 488 4. 019 -82. ,255 1.00 45. 27 B N

ATOM 12933 CA GLY B 220 -67. 331 2. 828 -83. ,085 1.00 48. 11 B c

ATOM 12936 C GLY B 220 -66. 055 2. 020 -82. ,879 1. 00 48. 36 B c

ATOM 12937 0 GLY B 220 -65. 661 1. 240 -83. ,748 1.00 47. 32 B 0

ATOM 12939 N ASN B 221 -65. 416 2. 204 -81, ,732 1.00 49. ,30 B N

ATOM 12940 CA ASN B 221 -64. 217 1. 456 -81.351 1. 00 49. ,61 B c

ATOM 12942 CB ASN B 221 -63. 203 2. 411 -80. ,679 1.00 45. ,94 B c

ATOM 12945 CG ASN B 221 -61. 979 1. 696 -80, ,064 1. 00 49. ,67 B c

ATOM 12946 ODl ASN B 221 -61. 742 0. 503 -80, ,268 1. 00 49. ,93 B 0

ATOM 12947 ND2 ASN B 221 -61. 198 2. 450 -79. ,295 1. 00 50. ,61 B N

ATOM 12950 C ASN B 221 -64. 637 0. 346 -80, ,400 1. 00 49. 23 B c

ATOM 12951 0 ASN B 221 -65. 138 0. 628 -79. ,314 1.00 9, 31 B 0

ATOM 12953 N ARG B 222 -64. 448 -0. 908 -80, ,814 1. 00 50. 87 B N

ATOM 12954 CA ARG B 222 -64. 813 -2. 073 -79, ,999 1. 00 49. 94 B c

ATOM 12956 CB ARG B 222 -64. 489 - 3 . 377 -80. .762 1.00 53. 20 B c

ATOM 12959 CG ARG B 222 -63. 073 - 3 . 915 -80, ,557 1.00 55. ,82 B c

ATOM 12962 CD ARG B 222 -62. 410 -4. 395 -81, ,839 1.00 57. ,98 B c

ATOM 12965 NE ARG B 222 -60. 972 -4. 136 -81. .757 1.00 61.66 B N

ATOM 12967 CZ ARG B 222 -60. 062 -4. 963 -81.238 1. 00 62. ,48 B c

ATOM 12968 NHl ARG B 222 -58. 792 -4. 584 -81.209 1. 00 62. ,89 B N

ATOM 12971 NH2 ARG B 222 -60. 399 -6. 156 -80. ,750 1.00 62. ,25 B N

ATOM 12974 C ARG B 222 -64. 160 -2. 068 -78, ,601 1. 00 45. ,12 B c human fD_Fab

ATOM 12975 O ARG B 222 -64. ,676 -2. 704 -77. ,679 1.00 40. 80 B 0

ATOM 12977 N LYS B 223 -63. ,029 -1. 361 -78. ,465 1.00 42. ,16 B N

ATOM 12978 CA LYS B 223 -62. 320 -1. 249 -77. ,192 1.00 40. ,82 B C

ATOM 12980 CB LYS B 223 -60. 809 -1. 058 -77. ,410 1.00 39. 58 B C

ATOM 12983 CG LYS B 223 -60. ,081 -2. 368 -77. ,780 1.00 34. 94 B C

ATOM 12986 CD LYS B 223 -58. ,572 -2. 195 -77. ,815 1.00 36. 15 B c

ATOM 12989 CE LYS B 223 -57. ,839 -3. 531 -77. ,993 1.00 34. 11 B c

ATOM 12992 NZ LYS B 223 -56. ,421 -3. 359 -78. ,404 1.00 27. ,07 B N

ATOM 12996 C LYS B 223 -62. 895 -0. 189 -76. ,260 1.00 41. ,35 B C

ATOM 12997 O LYS B 223 -62. ,513 -0. 137 -75. ,104 1.00 42. 47 B 0

ATOM 12999 N LYS B 224 -63. ,817 0. 643 -76. ,740 1.00 39. ,50 B N

ATOM 13000 CA LYS B 224 -64. ,518 1. 588 -75. ,871 1.00 38. 20 B C

ATOM 13002 CB LYS B 224 -64. ,052 3. 006 -76. 162 1.00 39. 50 B C

ATOM 13005 CG LYS B 224 -62. ,607 3. 232 -75. 776 1.00 42. 74 B c

ATOM 13008 CD LYS B 224 -62. ,433 3. 245 -74. ,258 1.00 42. 38 B c

ATOM 13011 CE LYS B 224 -60. ,990 3. 159 -73. 860 1.00 41.95 B c

ATOM 13014 NZ LYS B 224 -60. 519 1. 794 -74. 075 1.00 44. 97 B N

ATOM 13018 C LYS B 224 -66. ,032 1. 466 -76. Oil 1.00 36. 56 B c

ATOM 13019 O LYS B 224 -66. ,646 2. 232 -76. ,754 1.00 36. 70 B 0

ATOM 13021 N PRO B 225 -66. ,632 0. 490 -75. 301 1.00 34. ,97 B N

ATOM 13022 CA PRO B 225 -68. ,070 0. 254 -75. 349 1.00 36. ,47 B C

ATOM 13024 CB PRO B 225 -68. 280 -0. 845 -74. ,295 1.00 34. 18 B C

ATOM 13027 CG PRO B 225 -66. ,974 -1. 568 -74. 231 1.00 30. 19 B c

ATOM 13030 CD PRO B 225 -65. ,959 -0. 482 -74. ,417 1.00 31.91 B c

ATOM 13033 C PRO B 225 -68. 900 1. 492 -75. 022 1.00 36. 92 B c

ATOM 13034 O PRO B 225 -68. 424 2. 401 -74. 350 1.00 36. 87 B 0

ATOM 13035 N GLY B 226 -70. 124 1. 527 -75. 519 1.00 36. 70 B N

ATOM 13036 CA GLY B 226 -70. 974 2. 683 -75. 334 1.00 35. 53 B c

ATOM 13039 C GLY B 226 -71. ,490 2. 676 -73. ,921 1.00 31. 50 B c

ATOM 13040 O GLY B 226 -71. ,677 1. 615 -73. ,351 1.00 29. ,72 B 0

ATOM 13042 N ILE B 227 -71. 721 3. 866 -73. ,368 1.00 33. 86 B N

ATOM 13043 CA ILE B 227 -72. ,140 4. 026 -71. 979 1.00 34. 42 B c

ATOM 13045 CB ILE B 227 -71. ,107 4. 860 -71. ,184 1.00 29. 67 B c

ATOM 13047 CGI ILE B 227 -69. 721 4. 186 -71. 265 1.00 31. 36 B c

ATOM 13050 CDl ILE B 227 -68. 536 5. 101 -70. ,921 1.00 33. 46 B c

ATOM 13054 CG2 ILE B 227 -71. 554 5. 003 -69. 751 1.00 23. 84 B c

ATOM 13058 C ILE B 227 -73. 532 4. 666 -71. ,958 1.00 31.46 B c

ATOM 13059 O ILE B 227 -73. 799 5. 587 -72. 718 1.00 27. 65 B 0

ATOM 13061 N TYR B 228 -74. ,418 4. 131 -71. ,117 1.00 32. 62 B N

ATOM 13062 CA TYR B 228 -75. ,823 4. 576 -71. ,030 1.00 33. ,43 B c

ATOM 13064 CB TYR B 228 -76. 752 3. 618 -71. ,797 1.00 27. ,94 B c

ATOM 13067 CG TYR B 228 -76. ,270 3. 417 -73. ,204 1.00 27. ,28 B c

ATOM 13068 CDl TYR B 228 -76. ,741 4. 215 -74. ,251 1.00 26. ,87 B c

ATOM 13070 CEl TYR B 228 -76. 265 4. 056 -75. ,541 1.00 27. ,97 B c

ATOM 13072 CZ TYR B 228 -75. 290 3. 096 -75. ,788 1.00 29. ,27 B c

ATOM 13073 OH TYR B 228 -74. 781 2. 908 -77. ,043 1.00 28. 97 B 0

ATOM 13075 CE2 TYR B 228 -74. 807 2. 307 -74. ,765 1.00 27. 69 B c

ATOM 13077 CD2 TYR B 228 -75. 293 2. 474 -73. ,482 1.00 26. 53 B c

ATOM 13079 C TYR B 228 -76. 224 4. 648 -69. ,574 1.00 31. ,93 B c

ATOM 13080 0 TYR B 228 -75. 890 3. 756 -68. ,792 1.00 30. 88 B 0

ATOM 13082 N THR B 229 -76. 926 5. 721 -69. ,210 1.00 35. ,61 B N

ATOM 13083 CA THR B 229 -77. ,360 5. 918 -67. ,827 1.00 36. ,15 B c

ATOM 13085 CB THR B 229 -77. ,662 7. 393 -67. 541 1.00 33. ,39 B c

ATOM 13087 OGl THR B 229 -76. 569 8. 202 -68. 001 1.00 31. ,14 B 0

ATOM 13089 CG2 THR B 229 -77. ,891 7. 614 -66. 055 1.00 30. ,27 B c

ATOM 13093 C THR B 229 -78. ,615 5. 097 -67. ,605 1.00 36. ,51 B c

ATOM 13094 0 THR B 229 -79. 566 5. 247 -68. ,351 1.00 33. ,82 B 0

ATOM 13096 N ARG B 230 -78. 596 4. 225 -66. ,599 1.00 37. ,66 B N

ATOM 13097 CA ARG B 230 -79. ,714 3. 349 -66. ,297 1.00 38. ,32 B c

ATOM 13099 CB ARG B 230 -79. ,260 2. 205 -65. .388 1.00 36. .19 B c

ATOM 13102 CG ARG B 230 -78. 283 1. 262 -66. ,042 1.00 34. ,29 B c

ATOM 13105 CD ARG B 230 -77. ,791 0. 203 -65. ,078 1.00 38. ,80 B c

ATOM 13108 NE ARG B 230 -78. ,856 -0. 710 -64. ,675 1.00 40. ,83 B N

ATOM 13110 CZ ARG B 230 -79. ,497 -0. 689 -63. ,506 1.00 45. ,89 B c

ATOM 13111 NHl ARG B 230 -79. ,202 0. 205 -62. ,560 1.00 47. 53 B N

ATOM 13114 NH2 ARG B 230 -80. ,455 -1. 579 -63. 282 1.00 44. ,32 B N

ATOM 13117 C ARG B 230 -80. 828 4. 129 -65. ,616 1.00 38. ,52 B C

ATOM 13118 0 ARG B 230 -80. 672 4. 576 -64. ,493 1.00 41. ,67 B 0 human fD_Fab

ATOM 13120 N VAL B 231 -81. 959 4. 270 -66. 297 1.00 41. 98 B N

ATOM 13121 CA VAL B 231 -83. 085 5. 042 -65. ,770 1.00 39. 40 B C

ATOM 13123 CB VAL B 231 -84. 194 5. 220 -66. 832 1.00 40. 62 B C

ATOM 13125 CGl VAL B 231 -83. 638 5. 962 -68. 057 1.00 37. 57 B c

ATOM 13129 CG2 VAL B 231 -84. 813 3. 875 -67. 223 1.00 38. 48 B c

ATOM 13133 C VAL B 231 -83. 658 4. 456 -64. ,467 1.00 40. 57 B c

ATOM 13134 O VAL B 231 -84. ,074 5. 203 -63. ,577 1.00 44. 36 B 0

ATOM 13136 N ALA B 232 -83. ,638 3. 130 -64. ,344 1.00 44. 24 B N

ATOM 13137 CA ALA B 232 -84. ,155 2. 434 -63. ,156 1.00 41. 32 B c

ATOM 13139 CB ALA B 232 -84. ,119 0. 924 -63. 356 1.00 40. 64 B c

ATOM 13143 C ALA B 232 -83. 410 2. 817 -61. 889 1.00 41. 33 B c

ATOM 13144 O ALA B 232 -83. 996 2. 810 -60. 808 1.00 42. 63 B 0

ATOM 13146 N SER B 233 -82. 122 3. 140 -62. 021 1.00 41. 75 B N

ATOM 13147 CA SER B 233 -81. 321 3. 668 -60. 894 1.00 39. 46 B C

ATOM 13149 CB SER B 233 -79. 830 3. 742 -61. 232 1.00 36. 50 B C

ATOM 13152 OG ASER B 233 -79. 133 2. 647 -60. 669 0.70 39. 88 B 0

ATOM 13153 OG BSER B 233 -79. ,132 2. 635 -60. ,691 0.30 38. 56 B 0

ATOM 13156 C SER B 233 -81. ,767 5. 034 -60. ,384 1.00 39. 11 B c

ATOM 13157 O SER B 233 -81. 417 5. 400 -59. 272 1.00 38. 58 B 0

ATOM 13159 N TYR B 234 -82. 525 5. 775 -61. ,193 1.00 41. 57 B N

ATOM 13160 CA TYR B 234 -82. 943 7. 133 -60. 851 1.00 42. 46 B c

ATOM 13162 CB TYR B 234 -82. 348 8. 109 -61. 880 1.00 38. 68 B c

ATOM 13165 CG TYR B 234 -80. 826 8. 128 -61.873 1.00 38. 28 B c

ATOM 13166 CDl TYR B 234 -80. 130 9. Oil -61. 067 1.00 36. 79 B c

ATOM 13168 CEl TYR B 234 -78. 735 9. 025 -61. 049 1.00 37. 79 B c

ATOM 13170 CZ TYR B 234 -78. 028 8. 147 -61. 842 1.00 35. 06 B c

ATOM 13171 OH TYR B 234 -76. 655 8. 171 -61. 801 1.00 38. 15 B 0

ATOM 13173 CE2 TYR B 234 -78. 693 7. 244 -62. 642 1.00 34. 31 B c

ATOM 13175 CD2 TYR B 234 -80. 085 7. 239 -62. ,655 1.00 39. 08 B c

ATOM 13177 C TYR B 234 -84. 471 7. 255 -60. 756 1.00 44. 56 B c

ATOM 13178 O TYR B 234 -85. 027 8. 339 -60. ,927 1.00 41. 78 B 0

ATOM 13180 N ALA B 235 -85. 121 6. 131 -60. ,444 1.00 46. 08 B N

ATOM 13181 CA ALA B 235 -86. 575 6. 008 -60. 342 1.00 46. 01 B c

ATOM 13183 CB ALA B 235 -86. 916 4. 599 -59. 817 1.00 44. 15 B c

ATOM 13187 C ALA B 235 -87. 228 7. 061 -59. 442 1.00 46. 98 B c

ATOM 13188 O ALA B 235 -88. 151 7. 776 -59. 859 1.00 46. 99 B 0

ATOM 13190 N ALA B 236 -86. 742 7. 129 -58. 206 1.00 47. 65 B N

ATOM 13191 CA ALA B 236 -87. 254 8. 054 -57. 191 1.00 50. 20 B c

ATOM 13193 CB ALA B 236 -86. 527 7. 829 -55. ,847 1.00 46. 90 B c

ATOM 13197 C ALA B 236 -87. 125 9. 523 -57. ,599 1.00 52. 72 B c

ATOM 13198 O ALA B 236 -88. 024 10. 332 -57. 331 1.00 58. 18 B 0

ATOM 13200 N TRP B 237 -86. 005 9. 861 -58. 233 1.00 51. 02 B N

ATOM 13201 CA TRP B 237 -85. 726 11. 232 -58. 653 1.00 51. 73 B c

ATOM 13203 CB TRP B 237 -84. 242 11. 382 -59. 020 1.00 52. 99 B c

ATOM 13206 CG TRP B 237 -83. 917 12. 692 -59. 647 1.00 52. 33 B c

ATOM 13207 CDl TRP B 237 -83. 765 13. 873 -59. Oil 1.00 52. 89 B c

ATOM 13209 NEl TRP B 237 -83. 479 14. 865 -59. ,917 1.00 54. 15 B N

ATOM 13211 CE2 TRP B 237 -83. 436 14. 327 -61. 174 1.00 53. 31 B C

ATOM 13212 CD2 TRP B 237 -83. 705 12. 954 -61. 046 1.00 53. 76 B C

ATOM 13213 CE3 TRP B 237 -83. 713 12. 158 -62. 200 1.00 53. 52 B C

ATOM 13215 CZ3 TRP B 237 -83. 459 12. 761 -63. ,431 1.00 53. 04 B C

ATOM 13217 CH2 TRP B 237 -83. 194 14. 133 -63. ,524 1.00 52. 83 B c

ATOM 13219 CZ2 TRP B 237 -83. 182 14. 934 -62. ,411 1.00 53. 82 B c

ATOM 13221 C TRP B 237 -86. 625 11.666 -59. 815 1.00 54. 03 B c

ATOM 13222 O TRP B 237 -87. 186 12. 770 -59. 799 1.00 57. 03 B 0

ATOM 13224 N ILE B 238 -86. 779 10. 800 -60. ,814 1.00 52. 58 B N

ATOM 13225 CA ILE B 238 -87. 666 11.098 -61. ,941 1.00 53. 75 B c

ATOM 13227 CB ILE B 238 -87. 643 9. 979 -63. ,003 1.00 52. 14 B c

ATOM 13229 CGl ILE B 238 -86. 257 9. 879 -63. ,647 1.00 53. 14 B c

ATOM 13232 CDl ILE B 238 -86. 079 8. 648 -64. 509 1.00 53. 17 B c

ATOM 13236 CG2 ILE B 238 -88. 675 10. 241 -64. ,080 1.00 49. 65 B c

ATOM 13240 C ILE B 238 -89. 096 11. ,300 -61. ,451 1.00 56. 70 B c

ATOM 13241 O ILE B 238 -89. 802 12. ,194 -61. ,923 1.00 58. 39 B 0

ATOM 13243 N ASP B 239 -89. 517 10. 466 -60. ,503 1.00 58. 64 ^• B N

ATOM 13244 CA ASP B 239 -90. 854 10. 561 -59. ,923 1.00 57. 64 B c

ATOM 13246 CB ASP B 239 -91. 081 9. 411 -58. ,926 1.00 57. 34 B c

ATOM 13249 CG ASP B 239 -91. 491 8. 107 -59. ,613 1.00 54. 89 B c

ATOM 13250 ODl ASP B 239 -91. 906 8. 149 -60. ,796 1.00 52. 51 B 0 human fD_Fab

ATOM 13251 OD2 ASP B 239 -91. .414 7. ,043 -58, .959 1.00 51. ,93 B 0

ATOM 13252 C ASP B 239 -91. .086 11. ,911 -59, .250 1.00 58. ,18 B C

ATOM 13253 O ASP B 239 -92, .120 12. ,538 -59, .465 1.00 59. ,19 B 0

ATOM 13255 N SER B 240 -90. .112 12. ,357 -58, .459 1.00 58. ,62 B N

ATOM 13256 CA SER B 240 -90, .224 13. ,628 -57, .734 1.00 59. ,18 B C

ATOM 13258 CB SER B 240 -89, .015 13. ,858 -56, .812 1.00 55. ,78 B C

ATOM 13261 OG ASER B 240 -87, .843 14. ,154 -57, .547 0.60 53. ,57 B 0

ATOM 13262 OG 1 BSER B 240 -87. .843 14. ,149 -57, ,550 0.40 54. ,58 B 0

ATOM 13265 C SER B 240 -90, ,418 14. ,820 -58, .679 1.00 60. ,50 B C

ATOM 13266 O SER B 240 -91. .229 15. ,713 -58, .400 1.00 63. ,56 B 0

ATOM 13268 N VAL B 241 -89. .709 14. ,812 -59, .805 1.00 60. ,37 B N

ATOM 13269 CA VAL B 241 -89. ,753 15. ,917 -60. .769 1.00 59. ,54 B c

ATOM 13271 CB VAL B 241 -88. ,488 15. 922 -61. ,671 1.00 59. 50 B c

ATOM 13273 CGl VAL B 241 -88. ,539 17. ,076 -62. .679 1.00 60. ,57 B c

ATOM 13277 CG2 VAL B 241 -87. ,221 16. ,007 -60. ,822 1.00 54. ,74 B c

ATOM 13281 C VAL B 241 -91. ,032 15. ,893 -61. .630 1.00 60. 33 B c

ATOM 13282 O VAL B 241 -91. ,592 16. ,951 -61.959 1.00 61. 50 B 0

ATOM 13284 N LEU B 242 -91. ,492 14. ,694 -61. ,988 1.00 61. 52 B N

ATOM 13285 CA LEU B 242 -92. ,744 14. ,538 -62. ,744 1.00 63. 46 B c

ATOM 13287 CB LEU B 242 -92. ,825 13. 139 -63. ,371 1.00 63. 84 B c

ATOM 13290 CG LEU B 242 -92. ,150 12. 962 -64. ,729 1.00 63. 72 B c

ATOM 13292 CDl LEU B 242 -90. ,643 13. 179 -64. ,620 1.00 64. 91 B c

ATOM 13296 CD2 LEU B 242 -92. ,472 11. 577 -65. ,277 1.00 63. 77 B c

ATOM 13300 C LEU B 242 -93. 991 14. 783 -61. ,884 1.00 67. 37 B c

ATOM 13301 O LEU B 242 -94. 967 15. 374 -62. ,358 1.00 69. 32 B 0

ATOM 13303 N ALA B 243 -93. 950 14. 315 -60. ,634 1.00 68. 78 B N

ATOM 13304 CA ALA B 243 -95. ,081 14. 410 -59. ,704 1.00 68. 22 B c

ATOM 13306 CB ALA B 243 -94. 708 13. 783 -58. ,360 1.00 67. 63 B c

ATOM 13310 C ALA B 243 -95. ,541 15. 850 -59. ,502 1.00 70. 99 B c

ATOM 13311 O ALA B 243 -96. 733 16. 144 -59. ,556 1.00 69. 68 B 0

ATOM 13313 OXT ALA B 243 -94. ,726 16. 742 -59. ,271 1.00 73. 33 B 0

ATOM 13314 N GLU E 1 -63. 843 1. 238 -48. ,702 1.00 44. 90 E N

ATOM 13315 CA GLU E 1 -62. 449 0. 911 -49. ,127 1.00 46. 44 E c

ATOM 13317 CB GLU E 1 -61. 505 1. 043 -47. ,911 1.00 44. 70 E c

ATOM 13320 CG GLU E 1 -60. 197 0. 243 -47. ,970 1.00 47. 83 E c

ATOM 13323 CD GLU E 1 -59. 516 0. 019 -46. ,595 1.00 51. 68 E c

ATOM 13324 OEl GLU E 1 -60. 216 -0. 105 -45. ,554 1.00 51. 25 E 0

ATOM 13325 OE2 GLU E 1 -58. 259 -0. 076 -46. ,569 1.00 54. 21 E 0

ATOM 13326 C GLU E 1 -62. 374 -0. 499 -49. ,694 1.00 46. 62 E c

ATOM 13327 O GLU E 1 -62. 901 -1. 433 -49. ,106 1.00 46. 85 E 0

ATOM 13331 N VAL E 2 -61. 715 -0. 643 -50. ,839 1.00 47. 91 E N

ATOM 13332 CA VAL E 2 -61. 594 -1. 936 -51. ,501 1.00 41. 46 E c

ATOM 13334 CB VAL E 2 -61. 124 -1. 770 -52. ,952 1.00 36. 19 E c

ATOM 13336 CGl VAL E 2 -60. 805 -3. 114 -53. ,567 1.00 32. 27 E c

ATOM 13340 CG2 VAL E 2 -62. 187 -1. Oil -53. ,752 1.00 32. 30 E c

ATOM 13344 C VAL E 2 -60. 598 -2. 820 -50. ,756 1.00 41. 16 E c

ATOM 13345 O VAL E 2 -59. 507 -2. 382 -50. ,382 1.00 37. 55 E 0

ATOM 13347 N GLN E 3 -60. 980 -4. 075 -50. ,546 1.00 40. 03 E N

ATOM 13348 CA GLN E 3 -60. 075 -5. 058 -49. ,972 1.00 40. 61 E c

ATOM 13350 CB GLN E 3 -60. 222 -5. 140 -48. ,442 1.00 45. 32 E c

ATOM 13353 CG GLN E 3 -59. 643 -3. 924 -47. ,712 1.00 49. 62 E c

ATOM 13356 CD GLN E 3 -59. 601 -4. 077 -46. 197 1.00 51. 05 E c

ATOM 13357 OEl GLN E 3 -60. 523 -3. 651 -45. 483 1.00 54. 26 E 0

ATOM 13358 NE2 GLN E 3 -58. 520 -4. 667 -45. 695 1.00 55. 82 E N

ATOM 13361 C GLN E 3 -60. 269 -6. 426 -50. 603 1.00 36. 70 E c

ATOM 13362 O GLN E 3 -61. 369 -6. 791 -50. 978 1.00 36. 67 E 0

ATOM 13364 N LEU E 4 -59. 158 -7. 133 -50. 774 1.00 33. 76 E N

ATOM 13365 CA LEU E 4 -59. 135 -8. 474 -51. 308 1.00 35. 75 E c

ATOM 13367 CB LEU E 4 -58. 460 -8. 488 -52. 683 1.00 34. 19 E c

ATOM 13370 CG LEU E 4 -59. 207 -7. 861 -53. 859 1.00 32. 83 E c

ATOM 13372 CDl LEU E 4 -58. 353 -7. 911 -55. 149 1.00 32. 18 E c

ATOM 13376 CD2 LEU E 4 -60. 540 -8. 553 -54. 048 1.00 36. 85 E c

ATOM 13380 C LEU E 4 -58. 309 -9. 301 -50. 340 1.00 33. 96 E c

ATOM 13381 O LEU E 4 -57. 135 -9. 071 -50. 219 1.00 34. 26 E 0

ATOM 13383 N VAL E 5 -58. 929 -10. 252 -49. 649 1.00 34. 28 E N

ATOM 13384 CA VAL E 5 -58. 248 -11. 046 -48. 618 1.00 34. 95 E c

ATOM 13386 CB VAL E 5 -58. 878 -10. 895 -47. 194 1.00 31. 02 E c

ATOM 13388 CGl VAL E 5 -58. 141 -11.768 -46. 200 1.00 28. 68 E c human fD_Fab

ATOM 13392 CG2 VAL E 5 -58. ,848 -9. ,454 -46. 720 1.00 31. 26 E C

ATOM 13396 C VAL E 5 -58. 296 -12. ,532 -48. ,995 1.00 37. 33 E C

ATOM 13397 O VAL E 5 -59. 363 -13. ,126 -49. ,091 1.00 38. 82 E 0

ATOM 13399 N GLN E 6 -57. 120 -13. ,114 -49. 184 1.00 37. 55 E N

ATOM 13400 CA GLN E 6 -56. 979 -14. ,507 -49. 558 1.00 39. 16 E C

ATOM 13402 CB GLN E 6 -55. ,794 -14. ,689 -50. 517 1.00 40. 52 E c

ATOM 13405 CG GLN E 6 -55. ,825 -13. ,787 -51.749 1.00 41. 74 E c

ATOM 13408 CD GLN E 6 -54. ,664 -14. ,036 -52. ,692 1.00 40. 20 E c

ATOM 13409 OEl GLN E 6 -53. ,956 -13. ,100 -53. ,082 1.00 39. 12 E 0

ATOM 13410 NE2 GLN E 6 -54. ,453 -15. ,297 -53. ,054 1.00 36. 14 E N

ATOM 13413 C GLN E 6 -56. 739 -15. ,407 -48. 352 1.00 41. 39 E c

ATOM 13414 O GLN E 6 -56. ,237 -14. ,962 -47. ,312 1.00 35. 75 E 0

ATOM 13416 N SER E 7 -57. ,082 -16. ,686 -48. 518 1.00 44. 52 E N

ATOM 13417 CA SER E 7 -56. 833 -17. ,711 -47. 493 1.00 41.39 E c

ATOM 13419 CB SER E 7 -57. ,489 -19. ,049 -47. 865 1.00 36. 37 E c

ATOM 13422 OG SER E 7 -57. ,061 -19. ,518 -49. ,132 1.00 37. 05 E 0

ATOM 13424 C SER E 7 -55. ,337 -17. ,929 -47. ,280 1.00 41. 57 E c

ATOM 13425 O SER E 7 -54. ,512 -17. ,532 -48. ,096 1.00 41. 69 E 0

ATOM 13427 N GLY E 8 -55. ,010 -18. ,576 -46. ,171 1.00 38. 39 E N

ATOM 13428 CA GLY E 8 -53. ,647 -18. ,675 -45. 703 1.00 39. 31 E c

ATOM 13431 C GLY E 8 -52. ,834 -19. ,710 -46. ,447 1.00 39. 41 E c

ATOM 13432 O GLY E 8 -53. 330 -20. ,357 -47. 353 1.00 39. 94 E 0

ATOM 13434 N PRO E 9 -51. 573 -19. ,902 -46. 033 1.00 39. 61 E N

ATOM 13435 CA PRO E 9 -50. 695 -20. ,808 -46. 752 1.00 41. 44 E c

ATOM 13437 CB PRO E 9 -49. ,338 -20. ,583 -46. ,088 1.00 37. 79 E e

ATOM 13440 CG PRO E 9 -49. ,683 -20. ,197 -44. ,697 1.00 36. 61 E c

ATOM 13443 CD PRO E 9 -50. ,914 -19. ,342 -44. 841 1.00 37. 92 E c

ATOM 13446 C PRO E 9 -51. 129 -22. ,240 -46. 553 1.00 44. 28 E c

ATOM 13447 O PRO E 9 -51. ,708 -22. ,582 -45. 515 1.00 45. 48 E 0

ATOM 13448 N GLU E 10 -50. 866 -23. ,081 -47. 533 1.00 45. 85 E N

ATOM 13449 CA GLU E 10 -51. 288 -24. ,456 -47. 429 1.00 47. 59 E c

ATOM 13451 CB GLU E 10 -52. 607 -24. ,647 -48. 194 1.00 52. 54 E c

ATOM 13454 CG GLU E 10 -53. 753 -25. ,246 -47. 332 1.00 51. 72 E c

ATOM 13457 CD GLU E 10 -55. ,122 -24. ,820 -47. 802 1.00 54. 66 E c

ATOM 13458 OEl GLU E 10 -55. 343 -23. ,607 -47. ,970 1.00 58. 66 E 0

ATOM 13459 OE2 GLU E 10 -55. 996 -25. ,693 -47. ,988 1.00 65. 00 E 0

ATOM 13460 C GLU E 10 -50. ,212 -25. ,413 -47. ,910 1.00 46. 47 E c

ATOM 13461 O GLU E 10 -49. ,461 -25. ,105 -48. ,811 1.00 47. 48 E 0

ATOM 13463 N LEU E 11 -50. 128 -26. ,565 -47. ,249 1.00 48. 51 E N

ATOM 13464 CA LEU E 11 -49. 214 -27. ,639 -47. 621 1.00 47. 17 E c

ATOM 13466 CB LEU E 11 -48. 386 -28. ,086 -46. ,421 1.00 45. 98 E c

ATOM 13469 CG LEU E 11 -47. 540 -29. ,361 -46. ,543 1.00 46. 65 E c

ATOM 13471 CDl LEU E 11 -46. ,432 -29. .228 -47. ,563 1.00 37. ,22 E c

ATOM 13475 CD2 LEU E 11 -46. 968 -29, ,750 -45. ,170 1.00 46. ,81 E c

ATOM 13479 C LEU E 11 -50. ,086 -28. .778 -48. ,101 1.00 46. ,40 E c

ATOM 13480 O LEU E 11 -51. ,034 -29. ,173 -47. ,408 1.00 41. 34 E 0

ATOM 13482 N LYS E 12 -49. ,797 -29. ,272 -49. ,303 1. 00 46. ,11 E N

ATOM 13483 CA LYS E 12 -50. ,527 -30. ,395 -49. ,880 1.00 45. 68 E c

ATOM 13485 CB LYS E 12 -51. ,424 -29. ,953 -51. ,050 1.00 46. ,97 E c

ATOM 13488 CG LYS E 12 -52. 568 -29. ,013 -50. ,695 1.00 47. 84 E c

ATOM 13491 CD LYS E 12 -53. ,666 -29. ,663 -49. ,862 1.00 45. 72 E c

ATOM 13494 CE LYS E 12 -54. ,431 -28, .600 -49. ,087 1.00 47. ,15 E c

ATOM 13497 NZ LYS E 12 -55. ,503 -29, .135 -48. ,165 1.00 47. 92 E N

ATOM 13501 C LYS E 12 -49. ,550 -31, .430 -50. ,398 1.00 44. 26 E c

ATOM 13502 O LYS E 12 -48. ,413 -31, .122 -50. ,716 1.00 41. 42 E 0

ATOM 13504 N LYS E 13 -50. ,013 -32, . 666 -50. ,504 1.00 46. 16 E N

ATOM 13505 CA LYS E 13 -49. ,193 -33. .737 -51. ,057 1.00 50. 28 E c

ATOM 13507 CB LYS E 13 -49. ,688 -35. .116 -50. ,586 1.00 55. 37 E c

ATOM 13510 CG LYS E 13 -49. ,123 -35. ,574 -49. ,256 1.00 56. ,41 E c

ATOM 13513 CD LYS E 13 -49. ,702 -36. ,917 -48. ,846 1.00 58. ,04 E c

ATOM 13516 CE LYS E 13 -49. ,045 -37, .453 -47. ,562 1.00 60. ,39 E c

ATOM 13519 NZ LYS E 13 -48. ,989 -36, .448 -46. ,447 1.00 61. ,47 E N

ATOM 13523 C LYS E 13 -49. ,260 -33 , .688 -52. ,568 1. 00 46. ,18 E c

ATOM 13524 0 LYS E 13 -50. ,227 -33 , ,162 -53. ,116 1.00 43. ,96 E 0

ATOM 13526 N PRO E 14 -48. ,240 -34, .247 -53. ,254 1.00 47. ,11 E N

ATOM 13527 CA PRO E 14 -48. ,357 -34, .377 -54. ,698 1.00 49. ,79 E c

ATOM 13529 CB PRO E 14 -47. ,088 -35. .128 -55. ,100 1.00 48. ,49 E c

ATOM 13532 CG PRO E 14 -46. ,150 -34 .899 -53. ,985 1.00 48. ,39 E c human fD_Fab

ATOM 13535 CD PRO E 14 -46. 969 -34. ,798 -52, ,764 1.00 47. ,34 E C

ATOM 13538 C PRO E 14 -49. 570 -35. ,217 -55. ,046 1.00 51. ,77 E C

ATOM 13539 O PRO E 14 -49. 924 -36. ,134 -54. ,304 1.00 52. ,60 E 0

ATOM 13540 N GLY E 15 -50. 229 -34. ,880 -56. ,146 1.00 51. ,94 E N

ATOM 13541 CA GLY E 15 -51. 422 -35. ,599 -56. ,567 1.00 49. ,18 E C

ATOM 13544 C GLY E 15 -52. 693 -35. ,054 -55. ,952 1.00 46. ,49 E C

ATOM 13545 O GLY E 15 -53. 762 -35. ,240 -56. ,524 1.00 51.61 E 0

ATOM 13547 N ALA E 16 -52. 596 -34. 382 -54. ,805 1.00 43. ,60 E N

ATOM 13548 CA ALA E 16 -53. 766 -33. ,793 -54. ,152 1.00 44. ,63 E C

ATOM 13550 CB ALA E 16 -53. ,444 -33. ,465 -52. ,693 1.00 43. ,14 E C

ATOM 13554 C ALA E 16 -54. 255 -32. ,550 -54, ,896 1.00 43. ,69 E c

ATOM 13555 O ALA E 16 -53. 785 -32. ,248 -55, ,995 1.00 45. ,77 E 0

ATOM 13557 N SER E 17 -55. 217 -31.855 -54. ,298 1.00 42. ,60 E N

ATOM 13558 CA SER E 17 -55. 806 -30. 656 -54. ,877 1.00 46. ,80 E c

ATOM 13560 CB SER E 17 -57. 174 -30. ,975 -55. ,480 1.00 49. ,34 E c

ATOM 13563 OG SER E 17 -58. 176 -30. 943 -54. ,484 1.00 50. ,37 E 0

ATOM 13565 C SER E 17 -55. 960 -29. 585 -53. ,801 1.00 47. ,19 E c

ATOM 13566 O SER E 17 -56. 084 -29. ,894 -52. 606 1.00 44. ,07 E 0

ATOM 13568 N VAL E 18 -55. 975 -28. ,327 -54. 227 1.00 45. 21 E N

ATOM 13569 CA VAL E 18 -56. 062 -27. ,215 -53. 292 1.00 45. ,32 E c

ATOM 13571 CB VAL E 18 -54. 651 -26. ,593 -53. 050 1.00 38. ,35 E c

ATOM 13573 CGI VAL E 18 -54. 118 -25. ,861 -54. ,299 1.00 32. ,99 E c

ATOM 13577 CG2 VAL E 18 -54. ,664 -25. ,706 -51, ,834 1.00 44. ,01 E c

ATOM 13581 C VAL E 18 -57. ,083 -26. ,192 -53. ,792 1.00 46. ,11 E c

ATOM 13582 O VAL E 18 -57. 322 -26. ,082 -54. ,995 1.00 38. ,85 E 0

ATOM 13584 N LYS E 19 -57. ,708 -25. ,491 -52. ,849 1.00 50. ,11 E N

ATOM 13585 CA LYS E 19 -58. ,702 -24. ,478 -53. ,157 1.00 47. ,77 E C

ATOM 13587 CB LYS E 19 -60. ,083 -25. ,022 -52. ,796 1.00 53. 98 E C

ATOM 13590 CG LYS E 19 -61. 285 -24. ,318 -53. 432 1.00 55. 16 E c

ATOM 13593 CD LYS E 19 -62. ,047 -23. ,499 -52. ,394 1.00 62. ,22 E c

ATOM 13596 CE LYS E 19 -62. ,644 -24. ,338 -51.235 1.00 64. 40 E c

ATOM 13599 NZ LYS E 19 -62. ,332 -23. ,735 -49. 892 1.00 64. 90 E N

ATOM 13603 C LYS E 19 -58. 367 -23. ,188 -52. ,397 1.00 44. 25 E c

ATOM 13604 O LYS E 19 -58. 426 -23. ,141 -51. ,173 1.00 43. 85 E 0

ATOM 13606 N VAL E 20 -57. ,974 -22. ,162 -53. ,149 1.00 43. ,55 E N

ATOM 13607 CA VAL E 20 -57. ,590 -20. ,853 -52. ,607 1.00 42. 50 E c

ATOM 13609 CB VAL E 20 -56. ,334 -20. ,287 -53. ,381 1.00 38. 25 E c

ATOM 13611 CGI VAL E 20 -55. ,985 -18. ,853 -52. ,946 1.00 37. 69 E c

ATOM 13615 CG2 VAL E 20 -55. ,131 -21.222 -53. ,201 1.00 36. 25 E c

ATOM 13619 C VAL E 20 -58. ,785 -19. ,908 -52. ,734 1.00 41. 32 E c

ATOM 13620 O VAL E 20 -59. ,469 -19. ,902 -53. ,746 1.00 41. 59 E 0

ATOM 13622 N SER E 21 -59. ,031 -19. ,125 -51. ,695 1.00 43. 17 E N

ATOM 13623 CA SER E 21 -60. ,142 -18. ,201 -51. ,670 1.00 41. 18 E c

ATOM 13625 CB SER E 21 -60. ,872 -18. ,351 -50. ,342 1.00 45. 86 E c

ATOM 13628 OG SER E 21 -60. 096 -17. ,787 -49. 293 1.00 51. 53 E 0

ATOM 13630 C SER E 21 -59. 642 -16. ,766 -51. ,803 1.00 42. 70 E c

ATOM 13631 O SER E 21 -58. ,568 -16. ,428 -51.317 1.00 40. 78 E 0

ATOM 13633 N CYS E 22 -60. ,439 -15. ,934 -52. ,466 1.00 42. 67 E N

ATOM 13634 CA CYS E 22 -60. ,185 -14. ,507 -52. ,559 1.00 40. 27 E c

ATOM 13636 CB CYS E 22 -59. ,581 -14. ,147 -53. ,932 1.00 38. 82 E c

ATOM 13639 SG CYS E 22 -59. 393 -12. 382 -54. ,222 1.00 36. 53 E S

ATOM 13641 C CYS E 22 -61. 505 -13. ,783 -52. ,274 1.00 37. 98 E c

ATOM 13642 0 CYS E 22 -62. 374 -13. ,661 -53. ,144 1.00 37. 54 E 0

ATOM 13644 N LYS E 23 -61. 657 -13. ,365 -51. ,025 1.00 40. 50 E N

ATOM 13645 CA LYS E 23 -62. ,840 -12. ,658 -50. 559 1.00 43. 95 E c

ATOM 13647 CB LYS E 23 -63. 102 -12. ,950 -49. 074 1.00 47. 50 E C

ATOM 13650 CG LYS E 23 -64. 177 -12. ,066 -48. 464 1.00 46. 67 E C

ATOM 13653 CD LYS E 23 -65. 039 -12. 794 -47. 461 1.00 50. 56 E c

ATOM 13656 CE LYS E 23 -66. 204 -11. 895 -47. 003 1.00 52. 57 E c

ATOM 13659 NZ LYS E 23 -67. ,430 -12. ,089 -47. ,848 1.00 53. 40 E N

ATOM 13663 C LYS E 23 -62. ,693 -11. ,158 -50. 790 1.00 41. 62 E c

ATOM 13664 0 LYS E 23 -61. ,756 -10. ,536 -50. 291 1.00 41. 16 E 0

ATOM 13666 N ALA E 24 -63. 658 -10. 598 -51.516 1.00 39. 43 E N

ATOM 13667 CA ALA E 24 -63. 675 -9. 200 -51. 891 1.00 37. 97 E c

ATOM 13669 CB ALA E 24 -64. 116 -9. 069 -53. 341 1.00 34. 62 E c

ATOM 13673 C ALA E 24 -64. 624 -8. 411 -51. 000 1.00 37. 99 E c

ATOM 13674 0 ALA E 24 -65. 722 -8. 866 -50. 693 1.00 36. 02 E 0

ATOM 13676 N SER E 25 -64. 212 -7. 207 -50. 625 1.00 41. 15 E N

60£££0/0l0£Sil/13d Η0/.£0/Π0Ζ ΟΛ\ human fD_Fab

ATOM 13677 CA SER E 25 -65. ,062 -6. 290 -49. 878 1.00 40. ,65 E C

ATOM 13679 CB SER E 25 -64. ,798 -6. 446 -48. 380 1.00 44. 29 E C

ATOM 13682 OG SER E 25 -63. ,579 -5. 834 -47. 993 1.00 48. ,10 E 0

ATOM 13684 C SER E 25 -64. ,824 -4. 832 -50. ,302 1.00 39. 08 E C

ATOM 13685 O SER E 25 -63. ,750 -4. 501 -50. 832 1.00 36. 29 E 0

ATOM 13687 N GLY E 26 -65. ,840 -3. 984 -50. ,082 1.00 39. ,38 E N

ATOM 13688 CA GLY E 26 -65. ,745 -2. 548 -50. ,318 1.00 38. ,43 E c

ATOM 13691 C GLY E 26 -66. .167 -2. 099 -51. 693 1.00 39. ,54 E c

ATOM 13692 O GLY E 26 -65. ,964 -0. 938 -52. 041 1.00 43. ,17 E 0

ATOM 13694 N TYR E 27 -66.772 -3. 000 -52. 468 1.00 36. 40 E N

ATOM 13695 CA TYR E 27 -67. 205 -2. 681 -53. 822 1.00 35. ,01 E c

ATOM 13697 CB TYR E 27 -65. ,956 -2. 575 -54. ,714 1.00 25. ,41 E c

ATOM 13700 CG TYR E 27 -65. ,252 -3. 887 -55. ,019 1.00 24. ,34 E c

ATOM 13701 CDl TYR E 27 -65. ,558 -4. 589 -56. ,175 1.00 20. ,77 E c

ATOM 13703 CEl TYR E 27 -64. ,948 -5. 761 -56. ,489 1.00 17. ,10 E c

ATOM 13705 cz TYR E 27 -64. ,000 -6. 287 -55. 671 1.00 23. ,27 E c

ATOM 13706 OH TYR E 27 -63. ,441 -7. 492 -56. 061 1.00 24. ,75 E 0

ATOM 13708 CE2 TYR E 27 -63. ,627 -5. 616 -54. 496 1.00 26. ,15 E c

ATOM 13710 CD2 TYR E 27 -64. 267 -4. 410 -54. 177 1.00 27. ,15 E c

ATOM 13712 C TYR E 27 -68. ,187 -3. 757 -54. 273 1.00 34. 60 E c

ATOM 13713 O TYR E 27 -68. ,331 -4. 753 -53. ,585 1.00 31. ,39 E 0

ATOM 13715 N THR E 28 -68. ,871 -3. 545 -55. ,398 1.00 38. ,91 E N

ATOM 13716 CA THR E 28 -69. ,801 -4. 516 -55. 936 1.00 37. ,01 E c

ATOM 13718 CB THR E 28 -70. ,799 -3. 829 -56. 830 1.00 39. ,03 E c

ATOM 13720 OGl THR E 28 -71. ,411 -2. 777 -56. 083 1.00 39. ,54 E 0

ATOM 13722 CG2 THR E 28 -71.879 -4. 823 -57. 334 1.00 36. ,14 E c

ATOM 13726 C THR E 28 -69. ,021 -5. 579 -56. 691 1.00 37. ,90 E c

ATOM 13727 O THR E 28 -68. ,485 -5. 349 -57. 774 1.00 38. ,21 E 0

ATOM 13729 N PHE E 29 -68. ,976 -6. 755 -56. 097 1.00 39. 24 E N

ATOM 13730 CA PHE E 29 -68. ,215 -7. 892 -56. ,598 1.00 38. ,41 E c

ATOM 13732 CB PHE E 29 -68. ,560 -9. 086 -55. ,702 1.00 39. 58 E c

ATOM 13735 CG PHE E 29 -67. ,725 - -10. 304 -55. ,940 1.00 38. 46 E c

ATOM 13736 CDl PHE E 29 -66. ,421 - -10. 344 -55. ,524 1.00 36. ,15 E c

ATOM 13738 CEl PHE E 29 -65. ,657 - -11. 467 -55. ,730 1.00 37. ,54 E c

ATOM 13740 CZ PHE E 29 -66. ,201 - -12. 571 -56. 348 1.00 38. 88 E c

ATOM 13742 CE2 PHE E 29 -67. ,517 - -12. 551 -56. 749 1.00 38. ,77 E c

ATOM 13744 CD2 PHE E 29 -68. ,270 - -11. 431 -56. 549 1.00 36. ,53 E c

ATOM 13746 C PHE E 29 -68. ,431 -8. 200 -58. ,096 1.00 38. ,36 E c

ATOM 13747 O PHE E 29 -67. ,487 -8. 553 -58. ,798 1.00 36. ,25 E 0

ATOM 13749 N THR E 30 -69. ,646 -8. 016 -58. ,585 1.00 38. ,97 E N

ATOM 13750 CA THR E 30 -70. Oil -8. 370 -59. ,961 1.00 36. ,89 E c

ATOM 13752 CB THR E 30 -71. ,480 -8. 813 -59. ,965 1.00 40. ,53 E c

ATOM 13754 OGl THR E 30 -71. 623 -9. 967 -59. ,115 1.00 35. ,48 E 0

ATOM 13756 CG2 THR E 30 -71. 937 -9. 180 -61. ,370 1.00 45. ,26 E c

ATOM 13760 C THR E 30 -69. ,721 -7. 275 -61. ,004 1.00 34. 69 E c

ATOM 13761 O THR E 30 -69. ,822 -7. 521 -62. ,201 1.00 37. ,13 E 0

ATOM 13763 N ASN E 31 -69. ,333 -6. ,084 -60. ,543 1.00 35. 68 E N

ATOM 13764 CA ASN E 31 -68. .880 -4. 977 -61. ,420 1.00 37. ,12 E C

ATOM 13766 CB ASN E 31 -68. ,801 -3. ,657 -60. ,636 1.00 39. ,22 E c

ATOM 13769 CG ASN E 31 -70. .170 -3. Oil -60. ,364 1.00 41. ,42 E c

ATOM 13770 ODl ASN E 31 -71. ,235 -3. ,544 -60. ,725 1.00 35. ,04 E 0

ATOM 13771 ND2 ASN E 31 -70. ,126 -1. 828 -59. ,716 1.00 34. ,94 E N

ATOM 13774 C ASN E 31 -67. ,485 -5. 161 -62. ,023 1.00 33. ,52 E C

ATOM 13775 O ASN E 31 -67. ,151 -4. 549 -63. ,025 1.00 32. ,44 E 0

ATOM 13777 N TYR E 32 -66. ,668 -5. ,981 -61. ,382 1.00 35. ,12 E N

ATOM 13778 CA TYR E 32 -65. ,281 -6. ,185 -61. ,779 1.00 35, ,69 E C

ATOM 13780 CB TYR E 32 -64. ,302 -5. ,585 -60. ,741 1.00 35. ,46 E C

ATOM 13783 CG TYR E 32 -64. ,455 -4. 113 -60. .437 1.00 35. ,64 E c

ATOM 13784 CDl TYR E 32 -63. ,585 -3. 172 -60. ,983 1.00 34. ,14 E c

ATOM 13786 CEl TYR E 32 -63. ,733 -1. 821 -60. ,700 1.00 34. ,43 E c

ATOM 13788 CZ TYR E 32 -64. ,758 -1. 403 -59. ,874 1.00 35. ,69 E c

ATOM 13789 OH TYR E 32 -64. ,915 -0. ,066 -59. ,579 1.00 36. ,30 E 0

ATOM 13791 CE2 TYR E 32 -65. ,631 -2. ,316 -59. ,326 1.00 35. ,97 E c

ATOM 13793 CD2 TYR E 32 -65. .466 -3. 662 -59. ,593 1.00 36, ,28 E c

ATOM 13795 C TYR E 32 -64. .983 -7. 662 -61.799 1.00 34. ,94 E c

ATOM 13796 0 TYR E 32 -65. ,315 -8. ,359 -60. ,834 1.00 35. ,31 E 0

ATOM 13798 N GLY E 33 -64. ,310 -8. ,134 -62. ,844 1.00 36. ,76 E N

ATOM 13799 CA GLY E 33 -63. ,832 -9. ,514 -62. ,868 1.00 33. ,85 E c human fD_Fab

ATOM 13802 C GLY E 33 -62, ,684 -9. ,738 -61.909 1.00 33. 55 E C

ATOM 13803 O GLY E 33 -62. ,289 -8. ,834 -61. ,185 1.00 35. 55 E 0

ATOM 13805 N MET E 34 -62. .146 -10. ,952 -61.901 1.00 31. 83 E N

ATOM 13806 CA MET E 34 -61. ,020 -11. ,293 -61. ,033 1.00 32. 44 E C

ATOM 13808 CB MET E 34 -61. ,472 -12. ,138 -59. ,836 1.00 29. 60 E C

ATOM 13811 CG MET E 34 -60. 467 -12. ,219 -58, ,665 1.00 29. 01 E c

ATOM 13814 SD MET E 34 -60. ,198 -10. ,681 -57. ,740 1.00 25. 71 E S

ATOM 13815 CE MET E 34 -61. 691 -10. ,621 -56. ,742 1.00 22. 59 E c

ATOM 13819 C MET E 34 -59. 957 -12. 026 -61. ,830 1.00 32. 14 E c

ATOM 13820 O MET E 34 -60. ,250 -13. ,050 -62. ,456 1.00 32. 73 E 0

ATOM 13822 N ASN E 35 -58. ,733 -11. 473 -61. ,826 1.00 29. 81 E N

ATOM 13823 CA ASN E 35 -57. ,575 -12. ,123 -62. ,455 1.00 30. 69 E c

ATOM 13825 CB ASN E 35 -56. ,557 -11. ,088 -62. .949 1.00 32. 42 E c

ATOM 13828 CG ASN E 35 -57. ,154 -10. ,075 -63. ,892 1.00 28. 96 E c

ATOM 13829 ODl ASN E 35 -58. 179 -10. 327 -64. .537 1.00 27. 19 E 0

ATOM 13830 ND2 ASN E 35 -56. 498 -8. 925 -64. ,004 1.00 20. 76 E N

ATOM 13833 C ASN E 35 -56. ,890 -13. 012 -61. ,449 1.00 28. 73 E c

ATOM 13834 O ASN E 35 -56. 956 -12. ,765 -60. ,258 1.00 29. 20 E 0

ATOM 13836 N TRP E 36 -56. 234 -14. 060 -61. ,926 1.00 33. 58 E N

ATOM 13837 CA TRP E 36 - 55 . ,384 -14. 908 -61. ,077 1.00 32. 08 E c

ATOM 13839 CB TRP E 36 -55. 909 -16. 347 -61.017 1.00 33. 67 E c

ATOM 13842 CG TRP E 36 -57. 120 -16. 447 -60. ,132 1.00 34. 71 E c

ATOM 13843 CD1 TRP E 36 -58. ,410 -16. ,360 -60. ,523 1.00 34. 27 E c

ATOM 13845 NEl TRP E 36 -59. 238 -16. 466 -59. ,447 1.00 35. 55 E N

ATOM 13847 CE2 TRP E 36 -58. 489 -16. 601 -58. ,310 1.00 36. 20 E c

ATOM 13848 CD2 TRP E 36 -57. 139 -16. 588 -58. ,703 1.00 35. 79 E c

ATOM 13849 CE3 TRP E 36 -56. ,144 -16. ,716 -57. ,721 1.00 35. 42 E c

ATOM 13851 CZ3 TRP E 36 -56. ,532 -16. ,854 -56. ,387 1.00 34. 73 E c

ATOM 13853 CH2 TRP E 36 -57. 897 -16. ,864 -56. ,021 1.00 36. 73 E c

ATOM 13855 CZ2 TRP E 36 -58. .888 -16. ,734 -56. ,965 1.00 35. 58 E c

ATOM 13857 C TRP E 36 -53. 969 -14. ,878 -61. ,607 1.00 31. 47 E c

ATOM 13858 O TRP E 36 -53. ,750 -15. 026 -62. ,802 1.00 33. 33 E 0

ATOM 13860 N VAL E 37 -53. 009 -14. 694 -60. ,705 1.00 35. 00 E N

ATOM 13861 CA VAL E 37 -51. 603 -14. ,617 -61. ,076 1.00 32. 67 E c

ATOM 13863 CB VAL E 37 -51. 080 -13. 168 -61.011 1.00 34. 65 E c

ATOM 13865 CGI VAL E 37 -49. 576 -13. 112 -61. ,283 1.00 23. 13 E c

ATOM 13869 CG2 VAL E 37 -51. 870 -12. 272 -62. ,000 1.00 31. 91 E c

ATOM 13873 C VAL E 37 -50. 790 -15. ,531 -60. ,172 1.00 34. 05 E c

ATOM 13874 O VAL E 37 -51. 061 -15. ,647 -58. ,990 1.00 31. 60 E 0

ATOM 13876 N ARG E 38 -49. 795 -16. 183 -60. ,762 1.00 35. 67 E N

ATOM 13877 CA ARG E 38 -48. ,882 -17. ,083 -60. ,062 1.00 35. 50 E c

ATOM 13879 CB ARG E 38 -48. ,797 -18. ,370 -60. ,829 1.00 39. 19 E c

ATOM 13882 CG ARG E 38 -48. 263 -19. ,496 -60. ,063 1.00 41. 34 E c

ATOM 13885 CD ARG E 38 -48. ,182 -20. ,692 -60. ,961 1.00 40. 57 E c

ATOM 13888 NE ARG E 38 -46. 834 -20. ,908 -61.413 1.00 42. 44 E N

ATOM 13890 cz ARG E 38 -46. ,381 -22. ,054 -61. ,911 1.00 51. 83 E c

ATOM 13891 NH1 ARG E 38 -47. ,211 -23. ,098 -62. ,053 1.00 54. 55 E N

ATOM 13894 NH2 ARG E 38 -45. ,089 -22. ,153 -62, ,272 1.00 48. 12 E N

ATOM 13897 C ARG E 38 -47. 479 -16. ,517 -60. ,043 1.00 33. 86 E C

ATOM 13898 0 ARG E 38 -47. ,053 -15. ,886 -61. ,014 1.00 29. 58 E 0

ATOM 13900 N GLN E 39 -46. 776 -16. ,753 -58. ,934 1.00 32. 55 E N

ATOM 13901 CA GLN E 39 -45. 352 -16. ,519 -58. ,852 1.00 33. 04 E C

ATOM 13903 CB GLN E 39 -45. 069 -15. ,167 -58. ,217 1.00 34. 40 E C

ATOM 13906 CG GLN E 39 -43. 617 -14. ,765 -58. ,296 1.00 30. 44 E c

ATOM 13909 CD GLN E 39 -43. ,397 -13. ,337 -57. ,918 1.00 28. 61 E c

ATOM 13910 OEl GLN E 39 -44. ,069 -12. ,829 -57. ,035 1.00 30. 50 E 0

ATOM 13911 NE2 GLN E 39 -42. ,457 -12. ,654 -58. ,611 1.00 27. 68 E N

ATOM 13914 C GLN E 39 -44. 621 -17. ,659 -58. ,109 1.00 36. 74 E c

ATOM 13915 0 GLN E 39 -44. 648 -17. ,766 -56. ,882 1.00 38. 72 E 0

ATOM 13917 N ALA E 40 -43. 961 -18. ,506 -58. ,891 1.00 38. 76 E N

ATOM 13918 CA ALA E 40 -43. 091 -19. ,528 -58, ,359 1.00 39. 86 E c

ATOM 13920 CB ALA E 40 -42. 646 -20. ,466 -59. ,490 1.00 37. 02 E c

ATOM 13924 C ALA E 40 -41. 883 -18. ,865 -57. ,696 1.00 43. 43 E c

ATOM 13925 0 ALA E 40 -41. 495 -17. ,746 -58. ,088 1.00 43. 41 E 0

ATOM 13927 N PRO E 41 -41. 271 -19. ,548 -56, ,701 1.00 44. 36 E N

ATOM 13928 CA PRO E 41 -40. 203 -18. ,925 -55, ,882 1.00 48. 11 E C

ATOM 13930 CB PRO E 41 -39. 744 -20. ,068 -54, ,956 1.00 44. 72 E C

ATOM 13933 CG PRO E 41 -40. 878 -21. ,027 -54. ,942 1.00 43. 71 E c human fD_Fab

ATOM 13936 CD PRO E 41 -41.529 -20. ,939 -56. ,289 1.00 43. ,43 E C

ATOM 13939 C PRO E 41 -39. .021 -18. 392 -56. ,701 1.00 47. ,21 E C

ATOM 13940 O PRO E 41 -38. .340 -19. ,161 -57. ,385 1.00 47. ,25 E 0

ATOM 13941 N GLY E 42 -38. ,800 -17. 082 -56. ,631 1.00 48. ,31 E N

ATOM 13942 CA GLY E 42 -37. ,699 -16. 448 -57. ,356 1.00 49. ,39 E C

ATOM 13945 C GLY E 42 -37. ,946 -16. 233 -58. ,841 1.00 51. ,01 E c

ATOM 13946 O GLY E 42 -37. .054 -15. ,788 -59. ,560 1.00 54. ,21 E 0

ATOM 13948 N GLN E 43 -39. ,154 -16. ,532 -59. ,308 1.00 48. ,15 E N

ATOM 13949 CA GLN E 43 -39. ,475 -16. 409 -60.720 1.00 43. ,81 E c

ATOM 13951 CB GLN E 43 -40. ,217 -17. 649 -61. 220 1.00 52. ,72 E c

ATOM 13954 CG GLN E 43 -39. ,607 -18. 984 -60. 817 1.00 59. ,84 E c

ATOM 13957 CD GLN E 43 -38. ,241 -19. 191 -61. 403 1.00 63. ,71 E c

ATOM 13958 OEl GLN E 43 -38. ,092 -19. 854 -62. ,427 1.00 71. ,25 E 0

ATOM 13959 NE2 GLN E 43 -37. ,229 -18. 612 -60. ,771 1.00 63. ,85 E N

ATOM 13962 C GLN E 43 -40. ,345 -15. 171 -60. ,945 1.00 40. ,18 E c

ATOM 13963 O GLN E 43 -40. ,694 -14. 446 -59. ,990 1.00 39. ,51 E 0

ATOM 13965 N GLY E 44 -40. ,702 -14. ,955 -62. ,209 1.00 34. 84 E N

ATOM 13966 CA GLY E 44 -41. ,557 -13. 858 -62. ,592 1.00 34. 89 E c

ATOM 13969 C GLY E 44 -43. ,035 -14. ,087 -62. 383 1.00 34. 33 E C

ATOM 13970 O GLY E 44 -43. ,468 -15. 183 -62. ,043 1.00 37. ,50 E 0

ATOM 13972 N LEU E 45 -43. ,808 -13. 030 -62. ,594 1.00 33 . 83 E N

ATOM 13973 CA LEU E 45 -45. ,251 -13. 091 -62. ,518 1.00 32. 37 E C

ATOM 13975 CB LEU E 45 -45. ,803 -11.672 -62. ,378 1.00 29. ,21 E C

ATOM 13978 CG LEU E 45 -45. ,415 -10. 876 -61. 111 1.00 28. ,09 E C

ATOM 13980 CDl LEU E 45 -45. ,797 -9. ,413 -61. ,285 1.00 22. ,70 E c

ATOM 13984 CD2 LEU E 45 -46. ,057 -11. ,451 -59. ,831 1.00 26. ,91 E c

ATOM 13988 C LEU E 45 -45. ,833 -13. 792 -63. ,771 1.00 31. ,87 E c

ATOM 13989 O LEU E 45 -45. ,308 -13. ,637 -64. ,875 1.00 32. 32 E 0

ATOM 13991 N GLU E 46 -46. , 888 -14. ,582 -63. ,577 1.00 35. 22 E N

ATOM 13992 CA GLU E 46 -47. ,545 -15. ,340 -64. ,656 1.00 35. ,71 E c

ATOM 13994 CB GLU E 46 -47. ,256 -16. 825 -64. ,570 1.00 36. ,76 E c

ATOM 13997 CG GLU E 46 -45. ,813 -17. 201 -64. ,505 1.00 45. , 66 E c

ATOM 14000 CD GLU E 46 -45. ,639 -18. 701 -64. ,351 1.00 46. ,79 E c

ATOM 14001 OEl GLU E 46 -45. ,417 -19. ,156 -63. ,208 1.00 47. , 33 E 0

ATOM 14002 OE2 GLU E 46 -45. ,757 -19. ,418 -65. ,369 1.00 51. ,41 E 0

ATOM 14003 C GLU E 46 -49. ,055 -15. 179 -64. ,572 1.00 34. ,79 E c

ATOM 14004 O GLU E 46 -49. ,676 -15. ,617 -63. ,610 1.00 31. ,02 E 0

ATOM 14006 N TRP E 47 -49. 625 -14. ,548 -65. ,593 1.00 31. ,92 E N

ATOM 14007 CA TRP E 47 -51.047 -14. ,326 -65. ,682 1.00 34. ,58 E c

ATOM 14009 CB TRP E 47 -51. 324 -13. ,261 -66. ,748 1.00 32. ,25 E c

ATOM 14012 CG TRP E 47 -52. 610 -12. ,501 -66. ,577 1.00 29. ,02 E c

ATOM 14013 CDl TRP E 47 -52. ,798 -11. ,361 -65. ,869 1.00 29. ,34 E c

ATOM 14015 NEl TRP E 47 -54. ,106 -10. ,964 -65. ,942 1.00 29. , 66 E N

ATOM 14017 CE2 TRP E 47 -54. ,794 -11.859 -66. ,713 1.00 31.39 E c

ATOM 14018 CD2 TRP E 47 -53. ,876 -12. ,843 -67. ,132 1.00 30. ,81 E c

ATOM 14019 CE3 TRP E 47 -54. ,327 -13. 886 -67. ,955 1.00 29. ,84 E c

ATOM 14021 CZ3 TRP E 47 -55. ,651 -13. 907 -68. ,330 1.00 30. ,31 E c

ATOM 14023 CH2 TRP E 47 -56. ,549 -12. 912 -67. ,904 1.00 29. ,93 E c

ATOM 14025 CZ2 TRP E 47 -56. ,142 -11. ,883 -67. ,090 1.00 32. ,54 E c

ATOM 14027 C TRP E 47 -51.729 -15. ,694 -65. ,991 1.00 35. ,86 E c

ATOM 14028 O TRP E 47 -51. ,517 -16. ,296 -67. ,042 1.00 34. ,65 E 0

ATOM 14030 N MET E 48 -52. ,501 -16. ,191 -65. .029 1.00 33. ,14 E N

ATOM 14031 CA MET E 48 -53. ,079 -17. ,528 -65. .124 1.00 36. ,95 E c

ATOM 14033 CB MET E 48 -53. ,347 -18. ,079 -63. ,727 1.00 38. ,46 E c

ATOM 14036 CG MET E 48 -52, ,102 -18. ,358 -62. ,904 1.00 37. ,63 E c

ATOM 14039 SD MET E 48 -52. ,536 -18. ,897 -61. ,248 1.00 37. ,21 E s

ATOM 14040 CE MET E 48 -53. ,515 -20. ,373 -61.557 1.00 37. ,28 E c

ATOM 14044 C MET E 48 -54. ,380 -17. ,529 -65. .924 1.00 37. ,69 E c

ATOM 14045 O MET E 48 -54. ,620 -18. ,399 -66. ,769 1.00 38. ,59 E 0

ATOM 14047 N GLY E 49 -55. ,232 -16. ,554 -65. ,631 1.00 37. ,63 E N

ATOM 14048 CA GLY E 49 -56. ,505 -16. ,436 -66 , .305 1.00 39. .08 E c

ATOM 14051 C GLY E 49 -57. ,382 -15. ,400 -65, .640 1.00 37. .95 E c

ATOM 14052 0 GLY E 49 -56. ,974 -14. ,766 -64, .670 1.00 37. .07 E 0

ATOM 14054 N TRP E 50 -58. ,595 -15. ,243 -66. .161 1.00 38. ,55 E N

ATOM 14055 CA TRP E 50 -59. ,601 -14. ,422 -65. .491 1.00 39. .15 E c

ATOM 14057 CB TRP E 50 -59, ,710 -13. ,054 -66. ,151 1.00 34. ,89 E c

ATOM 14060 CG TRP E 50 -60. ,967 -12. ,738 -66. .833 1.00 34. ,40 E c

ATOM 14061 CDl TRP E 50 -61. ,572 -13. ,464 -67. ,800 1.00 35. ,08 E c human fD_Fab

ATOM 14063 NEl TRP E 50 -62. ,717 -12. 835 -68. ,215 1.00 34. 51 E N

ATOM 14065 CE2 TRP E 50 -62. 860 -11. 659 -67. ,532 1.00 32. 07 E C

ATOM 14066 CD2 TRP E 50 -61.760 -11. 555 -66. ,657 1.00 32. 86 E C

ATOM 14067 CE3 TRP E 50 -61. ,651 -10. ,426 -65. ,841 1.00 33. ,83 E c

ATOM 14069 CZ3 TRP E 50 -62. ,641 -9. 443 -65. ,931 1.00 35. 21 E c

ATOM 14071 CH2 TRP E 50 -63. ,732 -9. 583 -66. ,814 1.00 33. ,73 E c

ATOM 14073 CZ2 TRP E 50 -63. 851 -10. 672 -67. ,627 1.00 31. 82 E c

ATOM 14075 C TRP E 50 -60. 950 -15. 152 -65. 355 1.00 38. 83 E c

ATOM 14076 0 TRP E 50 -61. 256 -16. 076 -66. 110 1.00 35. 65 E 0

ATOM 14078 N ILE E 51 -61. 719 -14. 771 -64. ,346 1.00 37. 21 E N

ATOM 14079 CA ILE E 51 -63. 109 -15. 194 -64. ,253 1.00 38. ,56 E c

ATOM 14081 CB ILE E 51 -63. ,431 -16. ,063 -62. ,978 1.00 36. ,74 E c

ATOM 14083 CGI ILE E 51 -64. ,901 -16. 524 -63. ,007 1.00 33. 01 E c

ATOM 14086 CDl ILE E 51 -65. ,224 -17. 695 -62. ,095 1.00 31. 78 E c

ATOM 14090 CG2 ILE E 51 -63. ,142 -15. 299 -61. ,684 1.00 34. 92 E c

ATOM 14094 C ILE E 51 -63. 990 -13. ,947 -64. ,291 1.00 38. 32 E c

ATOM 14095 0 ILE E 51 -63. ,770 -13. 008 -63. 523 1.00 35. 84 E 0

ATOM 14097 N ASN E 52 -64. 983 -13. 941 -65. ,181 1.00 38. 12 E N

ATOM 14098 CA ASN E 52 -65. 980 -12. 878 -65. ,179 1.00 35. 83 E c

ATOM 14100 CB ASN E 52 -66. 668 -12. 781 -66. ,541 1.00 29. 70 E c

ATOM 14103 CG ASN E 52 -67. ,566 -11. ,561 -66. ,667 1.00 27. ,49 E c

ATOM 14104 ODl ASN E 52 -68. ,252 -11. 190 -65. ,722 1.00 22. 69 E 0

ATOM 14105 ND2 ASN E 52 -67. ,604 -10. 966 -67. ,863 1.00 20. 79 E N

ATOM 14108 C ASN E 52 -66. 953 -13. ,160 -64. ,033 1.00 35. 19 E c

ATOM 14109 0 ASN E 52 -67. 612 -14. 181 -64. ,028 1.00 31.67 E 0

ATOM 14111 N THR E 53 -66. 992 -12. 259 -63. ,051 1.00 38. 64 E N

ATOM 14112 CA THR E 53 -67. 800 -12. 417 -61. ,827 1.00 37. ,57 E C

ATOM 14114 CB THR E 53 -67. 331 -11. 467 -60. ,694 1.00 36. 19 E C

ATOM 14116 OGl THR E 53 -67. 376 -10. 111 -61.158 1.00 33. 71 E 0

ATOM 14118 CG2 THR E 53 -65. ,930 -11. ,815 -60. ,219 1.00 34. ,51 E C

ATOM 14122 C THR E 53 -69. 279 -12. 120 -62. ,009 1.00 38. 16 E c

ATOM 14123 0 THR E 53 -70. 088 -12. 383 -61. ,115 1.00 39. 37 E 0

ATOM 14125 N TYR E 54 -69. 622 -11. ,558 -63. ,160 1.00 38. 22 E N

ATOM 14126 CA TYR E 54 -71. 004 -11. ,268 -63. ,516 1.00 36. 95 E c

ATOM 14128 CB TYR E 54 -70. 979 -10. 053 -64. ,449 1.00 32. 64 E C

ATOM 14131 CG TYR E 54 -72. 284 -9. 346 -64. ,620 1.00 30. 68 E c

ATOM 14132 CDl TYR E 54 -72. 566 -8. 180 -63. ,922 1.00 28. 96 E c

ATOM 14134 CEl TYR E 54 -73. ,763 -7. ,524 -64. ,090 1.00 32. 48 E c

ATOM 14136 CZ TYR E 54 -74. 698 -8. ,037 -64. ,970 1.00 34. ,50 E c

ATOM 14137 OH TYR E 54 -75. 895 -7. ,408 -65. ,164 1.00 32. 98 E 0

ATOM 14139 CE2 TYR E 54 -74. ,435 -9. 191 -65. ,674 1.00 33. 89 E c

ATOM 14141 CD2 TYR E 54 -73. 228 -9. 828 -65. ,505 1.00 31. 33 E c

ATOM 14143 C TYR E 54 -71.636 -12. ,491 -64. ,187 1.00 40. ,31 E c

ATOM 14144 0 TYR E 54 -72. 758 -12. ,895 -63. ,883 1.00 41.56 E 0

ATOM 14146 N THR E 55 -70. 843 -13. 096 -65. ,053 1.00 40. 75 E N

ATOM 14147 CA THR E 55 -71. 260 -14. ,030 -66. ,054 1.00 39. 42 E c

ATOM 14149 CB THR E 55 -70. ,686 -13. ,427 -67. ,349 1.00 37. ,28 E c

ATOM 14151 OGl THR E 55 -71. ,717 -12. ,662 -67. ,976 1.00 36. ,16 E 0

ATOM 14153 CG2 THR E 55 -70. ,105 -14. ,426 -68. ,269 1.00 37. ,74 E c

ATOM 14157 C THR E 55 -70. ,787 -15. ,458 -65. ,774 1.00 41. ,06 E c

ATOM 14158 0 THR E 55 -71. ,422 -16. ,415 -66. ,217 1.00 43. ,21 E 0

ATOM 14160 N GLY E 56 -69. 692 -15. ,594 -65. ,031 1.00 39. 93 E N

ATOM 14161 CA GLY E 56 -69. ,137 -16. ,896 -64. ,665 1.00 38. ,10 E c

ATOM 14164 C GLY E 56 -68. ,187 -17. ,446 -65. ,707 1.00 39. 53 E c

ATOM 14165 0 GLY E 56 -67. 524 -18. ,451 -65. ,475 1.00 41. ,84 E 0

ATOM 14167 N GLU E 57 -68. ,130 -16. ,786 -66. .861 1.00 40. ,67 E N

ATOM 14168 CA GLU E 57 -67. ,199 -17. ,125 -67. ,922 1.00 40. ,79 E c

ATOM 14170 CB GLU E 57 -67. ,318 -16. ,118 -69. .071 1.00 42. ,40 E c

ATOM 14173 CG GLU E 57 -68. ,354 -16. ,423 -70. ,128 1.00 47. ,09 E c

ATOM 14176 CD GLU E 57 -68. ,694 -15. ,208 -70. ,987 1.00 50. ,01 E c

ATOM 14177 OEl GLU E 57 -68. 335 -14. ,072 -70. ,595 1.00 53. ,87 E 0

ATOM 14178 OE2 GLU E 57 -69. ,343 -15. ,385 -72. ,045 1.00 54. ,80 E 0

ATOM 14179 C GLU E 57 -65. ,774 -17. ,050 -67. ,411 1.00 40. ,71 E c

ATOM 14180 0 GLU E 57 -65. ,450 -16. ,215 -66, .566 1.00 37. ,71 E 0

ATOM 14182 N THR E 58 -64. ,924 -17. ,894 -67, .978 1.00 40. ,47 E N

ATOM 14183 CA THR E 58 -63. ,537 -18. ,002 -67. ,579 1.00 40. ,12 E c

ATOM 14185 CB THR E 58 -63. ,311 -19. ,280 -66. ,757 1.00 38. ,93 E c

ATOM 14187 OGl THR E 58 -64. ,019 -20. ,356 -67. .382 1.00 40. ,84 E 0 human fD_Fab

ATOM 14189 CG2 THR E 58 -63. .813 -19. 100 -65. ,311 1.00 29. ,97 E C

ATOM 14193 C THR E 58 -62. 671 -18. 019 -68. ,823 1.00 42. ,78 E C

ATOM 14194 O THR E 58 -63. ,108 -18. 459 -69. ,890 1.00 40. ,66 E 0

ATOM 14196 N THR E 59 -61.456 -17. 495 -68. ,686 1.00 43. ,90 E N

ATOM 14197 CA THR E 59 -60. 461 -17. 536 -69. ,756 1.00 40. ,41 E C

ATOM 14199 CB THR E 59 -60. 464 -16. 216 -70. ,519 1.00 38. ,26 E C

ATOM 14201 OGl THR E 59 -61. 819 -15. 874 -70. ,846 1.00 36. 03 E 0

ATOM 14203 CG2 THR E 59 -59. 610 -16. 295 -71. ,791 1.00 35. 03 E c

ATOM 14207 C THR E 59 -59. 097 -17. 815 -69. ,137 1.00 42. 26 E c

ATOM 14208 O THR E 59 -58. 681 -17. 143 -68. ,207 1.00 44. ,61 E 0

ATOM 14210 N TYR E 60 -58. 430 -18. 835 -69. ,658 1.00 42. ,47 E N

ATOM 14211 CA TYR E 60 -57. 203 -19. ,340 -69. 106 1.00 41. 09 E c

ATOM 14213 CB TYR E 60 -57. 359 -20. 838 -68. ,858 1.00 32. ,73 E c

ATOM 14216 CG TYR E 60 -58. 420 -21. 158 -67. 841 1.00 31. ,44 E c

ATOM 14217 CDl TYR E 60 -58. 151 -21. 060 -66. ,484 1.00 26. ,72 E c

ATOM 14219 CEl TYR E 60 -59. 123 -21. 340 -65. ,539 1.00 29. 46 E c

ATOM 14221 cz TYR E 60 -60. 374 -21. 734 -65. ,942 1.00 29. 17 E c

ATOM 14222 OH TYR E 60 -61. 311 -21.995 -65. ,000 1.00 29. 82 E 0

ATOM 14224 CE2 TYR E 60 -60. 687 -21. 834 -67. ,290 1.00 31. 69 E c

ATOM 14226 CD2 TYR E 60 -59. 706 -21. 553 -68. 237 1.00 31. ,73 E c

ATOM 14228 C TYR E 60 -56. 075 -19. 097 -70. ,094 1.00 43. ,64 E c

ATOM 14229 O TYR E 60 -56. 258 -19. 299 -71. 303 1.00 48. 36 E 0

ATOM 14231 N ALA E 61 -54. 925 -18. 650 -69. ,581 1.00 39. 60 E N

ATOM 14232 CA ALA E 61 -53. 681 -18. 671 -70. ,338 1.00 44. 30 E c

ATOM 14234 CB ALA E 61 -52. 512 -18. 100 -69. ,495 1.00 41. ,20 E c

ATOM 14238 C ALA E 61 -53. 399 -20. 117 -70. ,740 1.00 43. 61 E c

ATOM 14239 O ALA E 61 -53. 798 -21. 023 -70. ,030 1.00 42. 09 E 0

ATOM 14241 N ASP E 62 -52. 707 -20. 312 -71. ,866 1.00 47. 34 E N

ATOM 14242 CA ASP E 62 -52. 482 -21. 646 -72. ,448 1.00 49. ,74 E c

ATOM 14244 CB ASP E 62 -51. 625 -21. ,567 -73. ,709 1.00 53. ,16 E c

ATOM 14247 CG ASP E 62 -52. 415 -21. 150 -74. ,930 1.00 59. 02 E c

ATOM 14248 ODl ASP E 62 -51. 779 -20. 679 -75. ,895 1.00 64. ,20 E 0

ATOM 14249 OD2 ASP E 62 -53. 660 -21. 293 -74. ,936 1.00 60. ,48 E 0

ATOM 14250 C ASP E 62 -51. 851 -22. 644 -71. ,510 1.00 50. ,69 E c

ATOM 14251 O ASP E 62 -52. 212 -23. 815 -71. ,543 1.00 52. ,81 E 0

ATOM 14253 N ASP E 63 -50. 884 -22. 215 -70. ,711 1.00 53. 39 E N

ATOM 14254 CA ASP E 63 -50. 312 -23. 122 -69. ,732 1.00 54. 48 E c

ATOM 14256 CB ASP E 63 -49. 120 -22. 491 -69. ,010 1.00 55. 86 E c

ATOM 14259 CG ASP E 63 -47. 946 -22. 247 -69. ,958 1.00 55. 86 E c

ATOM 14260 ODl ASP E 63 -47. 974 -22. 795 -71. ,083 1.00 55. ,72 E 0

ATOM 14261 OD2 ASP E 63 -47. 009 -21.503 -69. ,596 1.00 56. ,26 E 0

ATOM 14262 C ASP E 63 -51.476 -23. 576 -68. ,857 1.00 55. ,89 E c

ATOM 14263 O ASP E 63 -52. 170 -24. 493 -69. ,233 1.00 64. ,48 E 0

ATOM 14265 N PHE E 64 -51. 718 -22. 943 -67. ,730 1.00 53. ,80 E N

ATOM 14266 CA PHE E 64 -52. 923 -23. 141 -66. ,874 1.00 48. ,72 E c

ATOM 14268 CB PHE E 64 -53. 149 -21. ,830 -66. ,133 1.00 38. ,75 E c

ATOM 14271 CG PHE E 64 -51. 880 -21. 305 -65. ,554 1.00 39. ,65 E c

ATOM 14272 CDl PHE E 64 -51. 327 -21. 907 -64. ,435 1.00 37. ,56 E c

ATOM 14274 CEl PHE E 64 -50. 111 -21. ,469 -63. ,929 1.00 37. ,84 E c

ATOM 14276 CZ PHE E 64 -49. 418 -20. ,459 -64. ,568 1.00 36. ,18 E c

ATOM 14278 CE2 PHE E 64 -49. 933 -19. ,888 -65. ,717 1.00 38. ,04 E c

ATOM 14280 CD2 PHE E 64 -51. 146 -20. 323 -66. ,217 1.00 38. ,51 E c

ATOM 14282 C PHE E 64 -54. 266 -23. ,754 -67. ,371 1.00 45. ,07 E c

ATOM 14283 O PHE E 64 -55. 254 -23. 737 -66. ,645 1.00 42. 26 E 0

ATOM 14285 N LYS E 65 -54. 299 -24. 399 -68. ,527 1.00 49. ,62 E N

ATOM 14286 CA LYS E 65 -55. 527 -25. 082 -68. ,960 1.00 51. ,97 E c

ATOM 14288 CB LYS E 65 -55. 725 -24. 988 -70. ,468 1.00 49. ,49 E c

ATOM 14291 CG LYS E 65 -56. 444 -23. 726 -70. ,905 1.00 49. ,30 E c

ATOM 14294 CD LYS E 65 -56. 300 -23. ,511 -72. ,401 1.00 49. ,43 E c

ATOM 14297 CE LYS E 65 -57. 026 -22. 280 -72. ,878 1.00 46. ,67 E c

ATOM 14300 NZ LYS E 65 -56. 521 -21. 878 -74. ,223 1.00 48. ,59 E N

ATOM 14304 C LYS E 65 -55. ,516 -26. 533 -68. ,488 1.00 51. ,18 E c

ATOM 14305 O LYS E 65 -54. ,520 -27. ,231 -68. ,639 1.00 56. ,87 E 0

ATOM 14307 N GLY E 66 -56. 608 -26. 946 -67. ,857 1.00 52. ,46 E N

ATOM 14308 CA GLY E 66 -56. 788 -28. 316 -67. ,380 1.00 51. ,54 E c

ATOM 14311 C GLY E 66 -56. 946 -28. 418 -65. ,876 1.00 48. 89 E c

ATOM 14312 O GLY E 66 -58. 059 -28. ,451 -65. ,367 1.00 49. ,09 E 0

ATOM 14314 N ARG E 67 -55. 825 -28. 443 -65. ,160 1.00 48. ,62 E N human fD_Fab

ATOM 14315 CA ARG E 67 -55. ,827 -28. 650 -63. 697 1.00 45. ,09 E C

ATOM 14317 CB ARG E 67 -54. ,457 -29. 127 -63. ,230 1.00 46. ,41 E C

ATOM 14320 CG ARG E 67 -54. 029 -30. 436 -63. ,825 1.00 44. ,47 E C

ATOM 14323 CD ARG E 67 -52. 702 -30. 869 -63. ,271 1.00 44. ,22 E C

ATOM 14326 NE ARG E 67 -51. ,634 -29. 902 -63. ,531 1.00 44. ,76 E N

ATOM 14328 CZ ARG E 67 -50. ,983 -29. 191 -62. ,601 1.00 44. ,19 E C

ATOM 14329 NHl ARG E 67 -51. 275 -29. 298 -61. ,304 1.00 41. ,02 E N

ATOM 14332 NH2 ARG E 67 -50. 008 -28. 373 -62. ,981 1.00 41.64 E N

ATOM 14335 C ARG E 67 -56. 174 -27. 426 -62. ,874 1.00 43. ,05 E C

ATOM 14336 O ARG E 67 -56. 204 -27. 510 -61. ,650 1.00 43. ,25 E 0

ATOM 14338 N PHE E 68 -56. 405 -26. 290 -63. ,527 1.00 41. 98 E N

ATOM 14339 CA PHE E 68 -56. 648 -25. 027 -62. ,833 1.00 40. ,86 E C

ATOM 14341 CB PHE E 68 -55. ,608 -23. 982 -63. ,277 1.00 35. ,04 E C

ATOM 14344 CG PHE E 68 -54. ,187 -24. 378 -62. ,984 1.00 30. ,69 E C

ATOM 14345 CDl PHE E 68 -53. ,544 -23. 914 -61. ,831 1.00 32. 16 E C

ATOM 14347 CEl PHE E 68 -52. 240 -24. 285 -61. ,531 1.00 29. 16 E C

ATOM 14349 CZ PHE E 68 -51.546 -25. 121 -62. ,392 1.00 32. 20 E C

ATOM 14351 CE2 PHE E 68 -52. 163 -25. 586 -63. 562 1.00 32. ,90 E c

ATOM 14353 CD2 PHE E 68 -53. 491 -25. 213 -63. ,847 1.00 31. 07 E c

ATOM 14355 C PHE E 68 -58. 055 -24. 547 -63. ,136 1.00 39. 27 E c

ATOM 14356 O PHE E 68 -58. ,399 -24. 352 -64. ,288 1.00 39. ,32 E 0

ATOM 14358 N VAL E 69 -58. ,871 -24. 376 -62. ,099 1.00 34. ,48 E N

ATOM 14359 CA VAL E 69 -60. 259 -24. Oil -62. ,281 1.00 34. ,18 E c

ATOM 14361 CB VAL E 69 -61. 187 -25. 211 -61. ,968 1.00 32. ,10 E c

ATOM 14363 CGI VAL E 69 -62. 626 -24. 815 -62. 200 1.00 24. ,47 E c

ATOM 14367 CG2 VAL E 69 -60. 784 -26. 464 -62. ,801 1.00 25. ,73 E c

ATOM 14371 C VAL E 69 -60. 668 -22. 838 -61. 396 1.00 36. ,47 E c

ATOM 14372 O VAL E 69 -60. 450 -22. 851 -60. ,187 1.00 38. ,21 E 0

ATOM 14374 N PHE E 70 -61. 283 -21. 831 -62. ,010 1.00 38. ,60 E N

ATOM 14375 CA PHE E 70 -61. ,809 -20. 683 -61. ,286 1.00 36. ,75 E c

ATOM 14377 CB PHE E 70 -61.649 -19. 379 -62. ,089 1.00 35. ,31 E c

ATOM 14380 CG PHE E 70 -60. 245 -19. 114 -62. ,609 1.00 31.20 E c

ATOM 14381 CDl PHE E 70 -59. 123 -19. 412 -61. 852 1.00 33. ,19 E c

ATOM 14383 CEl PHE E 70 -57. 843 -19. 138 -62. 328 1.00 34. ,59 E c

ATOM 14385 CZ PHE E 70 -57. 685 -18. 554 -63. ,570 1.00 33. ,48 E c

ATOM 14387 CE2 PHE E 70 -58. 813 -18. 225 -64. ,318 1.00 35. ,51 E c

ATOM 14389 CD2 PHE E 70 -60. 074 -18. 503 -63. ,835 1.00 29. ,56 E c

ATOM 14391 C PHE E 70 -63. 284 -20. 898 -60. ,990 1.00 39. ,33 E c

ATOM 14392 O PHE E 70 -63. 991 -21. 532 -61. ,758 1.00 42. ,75 E 0

ATOM 14394 N SER E 71 -63. 737 -20. 364 -59. ,866 1.00 39. ,96 E N

ATOM 14395 CA SER E 71 -65. 135 -20. ,428 -59. ,496 1.00 38. ,42 E c

ATOM 14397 CB SER E 71 -65. 465 -21. 781 -58. ,831 1.00 38. ,63 E c

ATOM 14400 OG SER E 71 -64. 755 -22. 007 -57. ,614 1.00 39. ,81 E 0

ATOM 14402 C SER E 71 -65. 514 -19. 239 -58. ,587 1.00 38. ,93 E c

ATOM 14403 O SER E 71 -64. 659 -18. 480 -58. ,157 1.00 37. ,12 E 0

ATOM 14405 N LEU E 72 -66. 805 -19. 094 -58. ,334 1.00 38. ,05 E N

ATOM 14406 CA LEU E 72 -67. ,380 -17. ,956 -57. ,617 1.00 41. ,54 E C

ATOM 14408 CB LEU E 72 -68. 248 -17. 093 -58. ,559 1.00 39. ,23 E C

ATOM 14411 CG LEU E 72 -67. 686 -16. ,085 -59. ,570 1.00 40. ,33 E c

ATOM 14413 CDl LEU E 72 -66. 309 -16. 427 -60. ,036 1.00 36. ,90 E c

ATOM 14417 CD2 LEU E 72 -68. 625 -15. ,977 -60. ,774 1.00 39. ,55 E c

ATOM 14421 C LEU E 72 -68. 305 -18. ,464 -56. ,517 1.00 44. ,32 E c

ATOM 14422 O LEU E 72 -68. 911 -19. ,527 -56. ,638 1.00 43. ,50 E 0

ATOM 14424 N ASP E 73 -68. 416 -17. 687 -55. ,454 1.00 44. ,97 E N

ATOM 14425 CA ASP E 73 -69. 580 -17. ,718 -54. ,583 1.00 47. ,54 E c

ATOM 14427 CB ASP E 73 -69. 231 -18. ,359 -53. ,225 1.00 50. ,00 E c

ATOM 14430 CG ASP E 73 -70. ,442 -18. ,480 -52. ,280 1.00 48. .17 E c

ATOM 14431 ODl ASP E 73 -71. ,534 -17. ,959 -52. ,582 1.00 45. ,01 E 0

ATOM 14432 OD2 ASP E 73 -70. 297 -19. 111 -51.214 1.00 48. ,37 E 0

ATOM 14433 C ASP E 73 -70. 009 -16. ,264 -54. ,415 1.00 47. ,12 E c

ATOM 14434 O ASP E 73 -69. 557 -15. ,589 -53. ,492 1.00 45. ,12 E 0

ATOM 14436 N THR E 74 -70. 880 -15. ,795 -55. ,310 1.00 48. ,86 E N

ATOM 14437 CA THR E 74 -71. ,311 -14. ,384 -55, .321 1.00 50, .38 E c

ATOM 14439 CB THR E 74 -72. ,150 -14. ,030 -56. ,566 1.00 47. .36 E c

ATOM 14441 OGl THR E 74 -73. 352 -14. ,802 -56. ,581 1.00 49. .80 E 0

ATOM 14443 CG2 THR E 74 -71. 365 -14. ,302 -57. ,839 1.00 46. .79 E c

ATOM 14447 C THR E 74 -72. 052 -13. ,966 -54. .039 1.00 54. ,37 E c

ATOM 14448 O THR E 74 -71. 999 -12. ,798 -53. ,654 1.00 55. ,42 E 0 human fD_Fab

ATOM 14450 N SER E 75 -72. 707 -14. 921 -53. ,373 1.00 55. 61 E N

ATOM 14451 CA SER E 75 -73. ,390 -14. 668 -52. ,091 1.00 54. 10 E C

ATOM 14453 CB SER E 75 -74. 097 -15. 935 -51. ,597 1.00 55. 62 E C

ATOM 14456 OG SER E 75 -73. 156 -16. 860 -51. ,073 1.00 55. 54 E 0

ATOM 14458 C SER E 75 -72. 447 -14. 171 -50. ,983 1.00 53. 26 E C

ATOM 14459 O SER E 75 -72. 851 -13. 378 -50. ,132 1.00 55. 95 E 0

ATOM 14461 N VAL E 76 -71. 207 -14. 654 -50. ,982 1.00 52. 67 E N

ATOM 14462 CA VAL E 76 -70. 182 -14. ,194 -50. ,032 1.00 49. 63 E C

ATOM 14464 CB VAL E 76 -69. 563 -15. 382 -49. ,245 1.00 51. 83 E C

ATOM 14466 CGI VAL E 76 -70. 619 -16. 060 -48. ,371 1.00 52. 23 E c

ATOM 14470 CG2 VAL E 76 -68. 896 -16. 395 -50. ,193 1.00 50. 94 E c

ATOM 14474 C VAL E 76 -69. 060 -13. ,368 -50. ,724 1.00 50. 30 E c

ATOM 14475 O VAL E 76 -68. 001 -13. 110 -50. ,139 1.00 48. 02 E 0

ATOM 14477 N SER E 77 -69. 314 -12. 950 -51. ,966 1.00 48. 54 E N

ATOM 14478 CA SER E 77 -68. 359 -12. 172 -52. ,764 1.00 42. 48 E c

ATOM 14480 CB SER E 77 -68. 292 -10. 724 -52. ,254 1.00 43. 10 E c

ATOM 14483 OG SER E 77 -69. 557 -10. 077 -52. ,293 1.00 46. 06 E 0

ATOM 14485 C SER E 77 -66. 947 -12. ,772 -52. ,766 1.00 38. 18 E c

ATOM 14486 O SER E 77 -65. 948 -12. ,056 -52. ,580 1.00 33. 62 E 0

ATOM 14488 N THR E 78 -66. 852 -14. ,082 -52. ,984 1.00 36. 07 E N

ATOM 14489 CA THR E 78 -65. 541 -14. ,761 -52. ,958 1.00 36. 13 E c

ATOM 14491 CB THR E 78 -65. 421 -15. ,788 -51.817 1.00 31. 40 E c

ATOM 14493 OGl THR E 78 -65. 679 -15. 131 -50. ,569 1.00 29. 81 E 0

ATOM 14495 CG2 THR E 78 -64. 020 -16. 464 -51. ,784 1.00 28. 20 E c

ATOM 14499 C THR E 78 -65. 271 -15. 437 -54. ,274 1.00 35. 17 E c

ATOM 14500 O THR E 78 -66. 188 -15. 960 -54. ,888 1.00 37. 01 E 0

ATOM 14502 N ALA E 79 -64. 017 -15. 372 -54. ,721 1.00 34. 93 E N

ATOM 14503 CA ALA E 79 -63. 550 -16. 091 -55. 901 1.00 35. 73 E c

ATOM 14505 CB ALA E 79 -62. 847 -15. ,145 -56. ,872 1.00 34. 07 E c

ATOM 14509 C ALA E 79 -62. 596 -17. ,178 -55. ,450 1.00 35. 37 E c

ATOM 14510 O ALA E 79 -61. 887 -17. ,028 -54. ,444 1.00 33. 85 E 0

ATOM 14512 N TYR E 80 -62. 558 -18. 267 -56. ,208 1.00 37. 57 E N

ATOM 14513 CA TYR E 80 -61. 775 -19. 437 -55. 828 1.00 37. 96 E c

ATOM 14515 CB TYR E 80 -62. 702 -20. 604 -55. 421 1.00 39. 43 E c

ATOM 14518 CG TYR E 80 -63. 570 -20. 287 -54. ,224 1.00 39. 80 E c

ATOM 14519 CDl TYR E 80 -63. 094 -20. 454 -52. ,932 1.00 39. 74 E c

ATOM 14521 CEl TYR E 80 -63. 893 -20. 153 -51. ,832 1.00 41. 06 E c

ATOM 14523 CZ TYR E 80 -65. 164 -19. 662 -52. ,036 1.00 39. 50 E c

ATOM 14524 OH TYR E 80 -65. 959 -19. 339 -50. ,958 1.00 42. 12 E 0

ATOM 14526 CE2 TYR E 80 -65. 645 -19. ,484 -53. .309 1.00 36. 33 E c

ATOM 14528 CD2 TYR E 80 -64. 856 -19. 778 -54. ,386 1.00 35. 56 E c

ATOM 14530 C TYR E 80 -60. 866 -19. 889 -56. ,946 1.00 36. 32 E c

ATOM 14531 O TYR E 80 -61. 174 -19. 735 -58. ,117 1.00 39. 34 E 0

ATOM 14533 N LEU E 81 -59. 736 -20. 456 -56. ,570 1.00 41. 21 E N

ATOM 14534 CA LEU E 81 -58. 854 -21. 121 -57. ,525 1.00 41. 17 E c

ATOM 14536 CB LEU E 81 -57. 500 -20. 421 -57. ,593 1.00 40. 03 E c

ATOM 14539 CG LEU E 81 -56. 354 -21. 133 -58. ,314 1.00 42. 20 E c

ATOM 14541 CDl LEU E 81 -56. 746 -21. 493 -59. ,749 1.00 40. 83 E c

ATOM 14545 CD2 LEU E 81 -55. 106 -20. 248 -58. ,291 1.00 40. 29 E c

ATOM 14549 C LEU E 81 -58. 689 -22. ,541 -57. ,034 1.00 42. 62 E c

ATOM 14550 O LEU E 81 -58. 222 -22. ,757 -55. ,920 1.00 41. 20 E 0

ATOM 14552 N GLN E 82 -59. 110 -23. ,497 -57. ,857 1.00 49. 03 E N

ATOM 14553 CA GLN E 82 -58. 985 -24. ,917 -57. ,551 1.00 45. 41 E c

ATOM 14555 CB GLN E 82 -60. 336 -25. 634 -57. ,816 1.00 57. 07 E c

ATOM 14558 CG GLN E 82 -60. 311 -27. 087 -58. ,423 1.00 60. 15 E c

ATOM 14561 CD GLN E 82 -60. 228 -28. ,221 -57. ,392 1.00 66. 10 E c

ATOM 14562 OEl GLN E 82 -60. 321 -27. ,999 -56. ,175 1.00 67. 78 E 0

ATOM 14563 NE2 GLN E 82 -60. 052 -29. ,455 -57. ,890 1.00 64. 18 E N

ATOM 14566 C GLN E 82 -57. 858 -25. 447 -58. ,417 1.00 41. 20 E c

ATOM 14567 O GLN E 82 -57. 908 -25. ,298 -59. ,638 1.00 41.12 E 0

ATOM 14569 N ILE E 83 -56. 830 -26. ,015 -57. ,786 1.00 38. 48 E N

ATOM 14570 CA ILE E 83 -55. 720 -26. ,665 -58. ,509 1.00 43. 11 E C

ATOM 14572 CB ILE E 83 -54. 289 -26. ,113 -58. ,147 1.00 43. 13 E C

ATOM 14574 CGI ILE E 83 -54. 252 -24. ,585 -58. ,012 1.00 41. 96 E c

ATOM 14577 CDl ILE E 83 -52. 895 -24. ,067 -57. ,494 1.00 41. 44 E c

ATOM 14581 CG2 ILE E 83 -53. 263 -26. ,597 -59. ,183 1.00 38. 32 E c

ATOM 14585 C ILE E 83 -55. 732 -28. ,146 -58. ,154 1.00 44. 91 E c

ATOM 14586 O ILE E 83 -55. 727 -28. ,504 -56. ,972 1.00 46. 38 E 0 human fD_Fab

ATOM 14588 N SER E 84 -55. ,727 -29. 005 -59. 166 1.00 47. ,61 E N

ATOM 14589 CA SER E 84 -55. ,842 -30. 444 -58. 926 1.00 50. 09 E C

ATOM 14591 CB SER E 84 -57. ,138 -31. 007 -59. 544 1.00 52. 24 E C

ATOM 14594 OG SER E 84 -57. ,114 -31. 013 -60. 974 1.00 54. 10 E 0

ATOM 14596 C SER E 84 -54. ,611 -31.171 -59. 448 1.00 50. ,02 E c

ATOM 14597 O SER E 84 -53. ,852 -30. 628 -60. 250 1.00 48. ,72 E 0

ATOM 14599 N SER E 85 -54. ,409 -32. 400 -58. 973 1.00 52. ,61 E N

ATOM 14600 CA SER E 85 -53. ,263 -33. 213 -59. 385 1.00 50. 91 E c

ATOM 14602 CB SER E 85 -53. ,438 -33. 647 -60. 857 1.00 55. 63 E c

ATOM 14605 OG SER E 85 -52. ,234 -34. 121 -61. 439 1.00 62. 22 E 0

ATOM 14607 C SER E 85 -51. ,952 -32. 458 -59. 136 1.00 50. 28 E c

ATOM 146Q8 O SER E 85 -51. ,069 -32. 401 -59. 987 1.00 45. 42 E 0

ATOM 14610 N LEU E 86 -51. ,844 -31.912 -57. 926 1.00 50. 81 E N

ATOM 14611 CA LEU E 86 -50. ,721 -31. 063 -57. 523 1.00 46. 89 E c

ATOM 14613 CB LEU E 86 -50. ,865 -30. 697 -56. 037 1.00 44. 22 E c

ATOM 14616 CG LEU E 86 -51. ,415 -29. 317 -55. 674 1.00 44. 35 E c

ATOM 14618 CDl LEU E 86 -52. ,055 -28. 588 -56. 842 1.00 41. 59 E c

ATOM 14622 CD2 LEU E 86 -52. ,350 -29. 381 -54. 478 1.00 42. 03 E c

ATOM 14626 C LEU E 86 -49. ,355 -31. 705 -57. 773 1.00 48. 62 E c

ATOM 14627 O LEU E 86 -49. ,159 -32. 892 -57. 513 1.00 49. 33 E 0

ATOM 14629 N LYS E 87 -48. ,424 -30. 892 -58. 281 1.00 51. 22 E N

ATOM 14630 CA LYS E 87 -47. ,028 -31.277 -58. 475 1.00 52. ,55 E c

ATOM 14632 CB LYS E 87 -46. 669 -31. 317 -59. 970 1.00 52. 12 E c

ATOM 14635 CG LYS E 87 -47. ,865 -31. 471 -60. 892 1.00 54. 13 E c

ATOM 14638 CD LYS E 87 -47. 483 -31. 696 -62. 353 1.00 54. 32 E c

ATOM 14641 CE LYS E 87 -48. 699 -32. 178 -63. 179 1.00 57. 56 E c

ATOM 14644 NZ LYS E 87 -49. 545 -33. 242 -62. 493 1.00 55. 90 E N

ATOM 14648 C LYS E 87 -46. 117 -30. 274 -57. 770 1.00 53. 53 E c

ATOM 14649 0 LYS E 87 -46. 536 -29. 150 -57. 476 1.00 50. 55 E 0

ATOM 14651 N ALA E 88 -44. ,881 -30. 704 -57. 512 1.00 49. 97 E N

ATOM 14652 CA ALA E 88 -43. ,857 -29. 922 -56. 814 1.00 48. 83 E c

ATOM 14654 CB ALA E 88 -42. ,521 -30. 679 -56. 845 1.00 45. 57 E c

ATOM 14658 C ALA E 88 -43. 683 -28. 549 -57. 433 1.00 48. 67 E c

ATOM 14659 O ALA E 88 -43. ,478 -27. 561 -56. 724 1.00 50. 91 E 0

ATOM 14661 N GLU E 89 -43. 782 -28. 505 -58. 759 1.00 47. 99 E N

ATOM 14662 CA GLU E 89 -43. 601 -27. 280 -59. 541 1.00 46. 76 E c

ATOM 14664 CB GLU E 89 -43. 358 -27. 645 -61. Oil 1.00 53. 20 E c

ATOM 14667 CG GLU E 89 -42. ,012 -28. 393 -61. 288 1.00 62. 65 E c

ATOM 14670 CD GLU E 89 -42. ,033 -29. 929 -61. 027 1.00 66. 49 E c

ATOM 14671 OEl GLU E 89 -43. ,075 -30. 591 -61.252 1.00 68. 00 E 0

ATOM 14672 OE2 GLU E 89 -40. ,983 -30. 477 -60. 610 1.00 68. 43 E 0

ATOM 14673 C GLU E 89 -44. ,761 -26. 265 -59. 433 1.00 44. 50 E c

ATOM 14674 O GLU E 89 -44. ,672 -25. 163 -59. 970 1.00 47. 36 E 0

ATOM 14676 N ASP E 90 -45. ,837 -26. 642 -58. 746 1.00 39. 67 E N

ATOM 14677 CA ASP E 90 -46. 972 -25. 760 -58. 506 1.00 40. 34 E c

ATOM 14679 CB ASP E 90 -48. 284 -26. 562 -58. 459 1.00 38. 92 E c

ATOM 14682 CG ASP E 90 -48. ,674 -27. 121 -59. 799 1.00 39. ,21 E c

ATOM 14683 ODl ASP E 90 -48. ,430 -26. 455 -60. 823 1.00 46. 00 E 0

ATOM 14684 OD2 ASP E 90 -49. ,261 -28. 218 -59. 830 1.00 39. 91 E 0

ATOM 14685 C ASP E 90 -46. ,808 -24. 969 -57. 217 1.00 35. 89 E c

ATOM 14686 O ASP E 90 -47. ,631 -24. 111 -56. 931 1.00 36. 06 E 0

ATOM 14688 N THR E 91 -45. ,768 -25. 298 -56. 448 1.00 36. 99 E N

ATOM 14689 CA THR E 91 -45. ,336 -24. 519 -55. 290 1.00 40. 24 E c

ATOM 14691 CB THR E 91 -44. ,064 -25. 173 -54. 623 1.00 41.15 E c

ATOM 14693 OGl THR E 91 -44. ,406 -26. 470 -54. 098 1.00 37. ,34 E 0

ATOM 14695 CG2 THR E 91 -43. ,472 -24. 283 -53. 510 1.00 33. ,61 E c

ATOM 14699 C THR E 91 -45. 054 -23. 070 -55. 739 1.00 40. ,83 E c

ATOM 14700 O THR E 91 -44. ,135 -22. 815 -56. 530 1.00 37. ,31 E 0

ATOM 14702 N ALA E 92 -45. 874 -22. 145 -55. 251 1.00 38. 52 E N

ATOM 14703 CA ALA E 92 -45. 863 -20. 797 -55. 740 1.00 37. ,15 E c

ATOM 14705 CB ALA E 92 -46. 258 -20. 788 -57. 221 1.00 32. 36 E c

ATOM 14709 C ALA E 92 -46. 815 -19. 960 -54. 907 1.00 38. 29 E c

ATOM 14710 O ALA E 92 -47. ,651 -20. 503 -54. 184 1.00 41.95 E 0

ATOM 14712 N VAL E 93 -46. ,663 -18. 639 -54. ,974 1.00 42. ,19 E N

ATOM 14713 CA VAL E 93 -47. 653 -17. 723 -54. 400 1.00 35. ,38 E c

ATOM 14715 CB VAL E 93 -47. 033 -16. 387 -53. 965 1.00 30. ,41 E c

ATOM 14717 CGI VAL E 93 -48. ,129 -15. 376 -53. 512 1.00 24. ,07 E c

ATOM 14721 CG2 VAL E 93 -46. ,006 -16. 631 -52. 841 1.00 25. ,96 E c human fD_Fab

ATOM 14725 C VAL E 93 -48. 704 -17. ,509 -55. ,474 1.00 36. ,78 E C

ATOM 14726 O VAL E 93 -48. 374 -17. ,304 -56. ,647 1.00 37. 05 E 0

ATOM 14728 N TYR E 94 -49. 967 -17. ,573 -55. ,067 1.00 37. 05 E N

ATOM 14729 CA TYR E 94 -51. 064 -17. ,297 -55. ,953 1.00 34. 57 E C

ATOM 14731 CB TYR E 94 -52. 018 -18. ,515 -56. ,044 1.00 32. 33 E C

ATOM 14734 CG TYR E 94 -51. 368 -19. ,719 -56. ,650 1.00 26. 57 E C

ATOM 14735 CDl TYR E 94 -51. 471 -19. 987 -58. ,013 1.00 31. 40 E c

ATOM 14737 CEl TYR E 94 -50. 837 -21.097 -58. ,578 1.00 30. ,94 E c

ATOM 14739 CZ TYR E 94 -50. 096 -21. ,935 -57. ,762 1.00 28. 98 E c

ATOM 14740 OH TYR E 94 -49. 454 -23. ,037 -58. ,266 1.00 32. ,20 E 0

ATOM 14742 CE2 TYR E 94 -49. 983 -21. ,674 -56. ,419 1.00 27. 72 E c

ATOM 14744 CD2 TYR E 94 -50. 621 -20. ,574 -55. 876 1.00 26. 74 E c

ATOM 14746 C TYR E 94 -51. 788 -16. ,047 -55. 468 1.00 35. 47 E c

ATOM 14747 O TYR E 94 -52. 208 -15. ,974 -54. 322 1.00 33. 58 E 0

ATOM 14749 N TYR E 95 -51. 938 -15. ,088 -56. 377 1.00 35. 87 E N

ATOM 14750 CA TYR E 95 -52. 624 -13. ,842 -56. ,123 1.00 34. 70 E c

ATOM 14752 CB TYR E 95 -51. 774 -12. ,655 -56. 634 1.00 34. 79 E c

ATOM 14755 CG TYR E 95 -50. 404 -12. ,515 -55. 989 1.00 31. 59 E c

ATOM 14756 CDl TYR E 95 -50. 232 -11.788 -54. 820 1.00 33. 27 E c

ATOM 14758 CEl TYR E 95 -48. 992 -11. 663 -54. 231 1.00 35. 33 E c

ATOM 14760 CZ TYR E 95 -47. 894 -12. ,271 -54. ,818 1.00 35. ,34 E c

ATOM 14761 OH TYR E 95 -46. 640 -12. ,157 -54. ,251 1.00 34. 91 E 0

ATOM 14763 CE2 TYR E 95 -48. 041 -12. ,970 -55. ,985 1.00 34. ,39 E c

ATOM 14765 CD2 TYR E 95 -49. 287 -13. ,094 -56. ,560 1.00 34. 44 E c

ATOM 14767 C TYR E 95 -53. 926 -13. ,818 -56. ,867 1.00 34. 24 E c

ATOM 14768 O TYR E 95 -54. 034 -14. 379 -57. ,935 1.00 30. 86 E 0

ATOM 14770 N CYS E 96 -54. 915 -13. ,136 -56. ,297 1.00 39. 15 E N

ATOM 14771 CA CYS E 96 -56. 054 -12. 634 -57. ,056 1.00 36. 84 E c

ATOM 14773 CB CYS E 96 -57. 347 -12. ,894 -56. 305 1.00 34. 36 E c

ATOM 14776 SG CYS E 96 -57. 469 -12. ,112 -54. ,703 1.00 30. 90 E s

ATOM 14778 C CYS E 96 -55. 837 -11. ,149 -57. 270 1.00 35. 76 E c

ATOM 14779 O CYS E 96 -55. 327 -10. 474 -56. ,398 1.00 34. 26 E 0

ATOM 14781 N GLU E 97 -56. 168 -10. 665 -58. ,458 1.00 35. 16 E N

ATOM 14782 CA GLU E 97 -56. 138 -9. 248 -58. ,776 1.00 34. 01 E c

ATOM 14784 CB GLU E 97 -55. 032 -8. ,931 -59. ,782 1.00 32. ,55 E c

ATOM 14787 CG GLU E 97 -54. 969 -7. 472 -60. ,235 1.00 28. ,75 E c

ATOM 14790 CD GLU E 97 -54. 193 -7. 272 -61. ,526 1.00 30. ,95 E c

ATOM 14791 OEl GLU E 97 -54. 283 -8. ,124 -62. ,413 1.00 33. ,45 E 0

ATOM 14792 OE2 GLU E 97 -53. 493 -6. 249 -61. ,670 1.00 35. 22 E 0

ATOM 14793 C GLU E 97 -57. 473 -8. ,895 -59. ,371 1.00 29. 38 E c

ATOM 14794 O GLU E 97 -57. 901 -9. ,511 -60. ,344 1.00 30. 20 E 0

ATOM 14796 N ARG E 98 -58. 135 -7. ,920 -58. ,775 1.00 26. 13 E N

ATOM 14797 CA ARG E 98 -59. 344 -7. ,367 -59. 325 1.00 31.32 E c

ATOM 14799 CB ARG E 98 -59. 960 -6. ,473 -58. ,255 1.00 29. 42 E c

ATOM 14802 CG ARG E 98 -61. 218 -5. ,720 -58. ,636 1.00 25. 79 E c

ATOM 14805 CD ARG E 98 -60. 959 -4. ,254 -58. ,396 1.00 30. 55 E c

ATOM 14808 NE ARG E 98 -62. 023 -3. ,624 -57. ,670 1.00 31. 90 E N

ATOM 14810 CZ ARG E 98 -62. 065 -2. ,347 -57. ,321 1.00 29. ,65 E c

ATOM 14811 NHl ARG E 98 -61. 076 -1. ,501 -57. ,612 1.00 29. 20 E N

ATOM 14814 NH2 ARG E 98 -63. 132 -1. ,927 -56. ,669 1.00 30. ,50 E N

ATOM 14817 C ARG E 98 -59. 061 -6. ,591 -60. ,630 1.00 32. ,85 E c

ATOM 14818 O ARG E 98 -58. 128 -5. ,762 -60. ,698 1.00 32. ,22 E 0

ATOM 14820 N GLU E 99 -59. 879 -6. ,869 -61. ,652 1.00 35. ,14 E N

ATOM 14821 CA GLU E 99 -59. 702 -6. ,335 -63. ,021 1.00 36. 06 E c

ATOM 14823 CB GLU E 99 -60. 130 -7. ,399 -64. ,035 1.00 30. ,28 E c

ATOM 14826 CG GLU E 99 -60. 001 -6. ,984 -65. ,476 1.00 27. ,31 E c

ATOM 14829 CD GLU E 99 -58. 652 -6. ,394 -65. ,796 1.00 26. ,54 E c

ATOM 14830 OEl GLU E 99 -57. 632 -6. ,732 -65. ,126 1.00 31. ,02 E 0

ATOM 14831 OE2 GLU E 99 -58. 608 -5. ,606 -66. ,744 1.00 24. ,43 E 0

ATOM 14832 C GLU E 99 -60. 561 -5. ,078 -63. Oil 1.00 39. ,92 E c

ATOM 14833 O GLU E 99 -61. 768 -5. ,129 -63. ,258 1.00 46. ,26 E 0

ATOM 14835 N GLY E 100 -59. 897 -3. ,931 -62. ,880 1.00 44. ,00 E N

ATOM 14836 CA GLY E 100 -60. 090 -2. ,709 -63. ,615 1.00 41. ,67 E c

ATOM 14839 C GLY E 100 -60. 326 -1. ,775 -62. ,401 1.00 42. 26 E c

ATOM 14840 O GLY E 100 -60. 464 -2. ,226 -61. ,251 1.00 47. ,60 E 0

ATOM 14842 N GLY E 101 -60. 355 -0. ,475 -62. ,620 1.00 40. ,74 E N

ATOM 14843 CA GLY E 101 -60. 479 0. ,469 -61. ,512 1.00 38. ,89 E c

ATOM 14846 C GLY E 101 -59. 158 0. ,669 -60. ,789 1.00 39. ,72 E c human fD_Fab

ATOM 14847 O GLY E 101 -58. ,113 0. 242 -61.282 1. 00 37. 01 E 0

ATOM 14849 N VAL E 108 -59. ,217 1. 339 -59. 629 1. 00 36. 57 E N

ATOM 14850 CA VAL E 108 -58. ,059 1. 498 -58. ,762 1. 00 33. 15 E C

ATOM 14852 CB VAL E 108 -58. ,370 2. 226 -57. ,395 1. 00 27. 55 E C

ATOM 14854 CGI VAL E 108 -57. 192 2. 078 -56. ,380 1. 00 24. 81 E C

ATOM 14858 CG2 VAL E 108 -58. ,635 3. 681 -57. ,606 1. 00 25. 71 E c

ATOM 14862 C VAL E 108 -57. ,524 0. 106 -58. ,493 1. 00 32. 43 E c

ATOM 14863 O VAL E 108 -58. ,220 -0. 745 -57. ,970 1. 00 35. 21 E 0

ATOM 14865 N ASN E 109 -56. ,284 -0. 126 -58. ,872 1. 00 32. 21 E N

ATOM 14866 CA ASN E 109 -55. ,751 -1. 498 -58. ,991 1. 00 33. 12 E c

ATOM 14868 CB ASN E 109 -54. ,472 -1. 489 -59. ,830 1. 00 21. 29 E c

ATOM 14871 CG ASN E 109 -54. ,026 -2. 864 -60. ,237 1. 00 25. 00 E c

ATOM 14872 OOl ASN E 109 -54. 638 -3. 485 -61. ,107 1. 00 29. 36 E 0

ATOM 14873 ND2 ASN E 109 -52. 944 -3. 353 -59. 632 1. 00 17. 36 E N

ATOM 14876 C ASN E 109 -55. 493 -2. 157 -57. ,636 1. 00 34. 60 E c

ATOM 14877 0 ASN E 109 -54. 688 -1. 689 -56. ,863 1. 00 28. 84 E 0

ATOM 14879 N ASN E 110 -56. ,200 -3. 252 -57. ,367 1. 00 37. 92 E N

ATOM 14880 CA ASN E 110 -56. ,147 -3. 904 -56. ,082 1. 00 35. 37 E c

ATOM 14882 CB ASN E 110 -57. ,473 -3. 754 -55. 345 1. 00 36. 56 E c

ATOM 14885 CG ASN E 110 -57. 565 -2. 459 -54. 565 1. 00 32. 82 E c

ATOM 14886 ODl ASN E 110 -57. 090 -2. 377 -53. ,443 1. 00 34. 22 E 0

ATOM 14887 ND2 ASN E 110 -58. 187 -1. 445 -55. ,157 1. 00 30. 04 E N

ATOM 14890 C ASN E 110 -55. 785 -5. 372 -56. 212 1. 00 34. 33 E c

ATOM 14891 0 ASN E 110 -56. 334 -6. 074 -57. 033 1. 00 35. 55 E 0

ATOM 14893 N TRP E 111 -54. 862 -5. 804 -55. 353 1. 00 34. 26 E N

ATOM 14894 CA TRP E 111 -54. 376 -7. 168 -55. 287 1. 00 34. 54 E c

ATOM 14896 CB TRP E 111 -52. 862 -7. 231 -55. ,499 1. 00 27. 98 E c

ATOM 14899 CG TRP E 111 -52. 417 -7. 018 -56. ,901 1. 00 25. 99 E c

ATOM 14900 CDl TRP E 111 -52. 573 -5. 892 -57. ,646 1. 00 25. 54 E c

ATOM 14902 NEl TRP E 111 -52. ,048 -6. 073 -58. ,889 1. 00 25. 21 E N

ATOM 14904 CE2 TRP E 111 -51. ,527 -7. 331 -58. ,971 1. 00 20. 53 E c

ATOM 14905 CD2 TRP E 111 -51. 740 -7. 955 -57. ,729 1. 00 25. 45 E c

ATOM 14906 CE3 TRP E 111 -51.304 -9. 275 -57. ,548 1. 00 22. 78 E c

ATOM 14908 CZ3 TRP E 111 -50. 674 -9. 898 -58. 582 1. 00 24. 49 E c

ATOM 14910 CH2 TRP E 111 -50. 472 -9. 242 -59. 820 1. 00 25. 46 E c

ATOM 14912 CZ2 TRP E 111 -50. 894 -7. 966 -60. 026 1. 00 22. 46 E c

ATOM 14914 C TRP E 111 -54. 674 -7. 753 -53. ,910 1. 00 37. 06 E c

ATOM 14915 0 TRP E 111 -54. 642 -7. 042 -52. ,894 1. 00 31. 60 E 0

ATOM 14917 N GLY E 112 -54. ,994 -9. 042 -53. ,896 1. 00 35. 05 E N

ATOM 14918 CA GLY E 112 -54. ,944 -9. 828 -52. ,674 1. 00 37. 99 E c

ATOM 14921 C GLY E 112 -53. ,503 -9. 972 -52. ,194 1. 00 37. 92 E c

ATOM 14922 0 GLY E 112 -52. ,560 -9. 660 -52. ,924 1. 00 36. ,55 E 0

ATOM 14924 N GLN E 113 -53. ,330 -10. 439 -50. ,963 1. 00 35. ,53 E N

ATOM 14925 CA GLN E 113 -52. ,000 -10. 499 -50. ,354 1. 00 33. 00 E c

ATOM 14927 CB GLN E 113 -52. 082 -10. 474 -48. ,813 1. 00 32. 94 E c

ATOM 14930 CG GLN E 113 -52. 224 -11. 851 -48. ,078 1. 00 32. 86 E c

ATOM 14933 CD GLN E 113 -53. 648 -12. 373 -48. ,036 1. 00 31.15 E c

ATOM 14934 OEl GLN E 113 -54. 494 -11.960 -48. ,813 1. 00 31. 61 E 0

ATOM 14935 NE2 GLN E 113 -53. 917 -13. 290 -47. ,115 1. 00 33. 20 E N

ATOM 14938 C GLN E 113 -51. 161 -11.707 -50. ,826 1. 00 36. 26 E c

ATOM 14939 0 GLN E 113 -49. ,972 -11. ,802 -50. ,536 1. 00 35. ,38 E 0

ATOM 14941 N GLY E 114 -51. ,791 -12. ,642 -51. ,529 1. 00 37. ,44 E N

ATOM 14942 CA GLY E 114 -51. ,108 -13. ,856 -51. ,940 1. 00 36. ,56 E c

ATOM 14945 C GLY E 114 -51. ,358 -15. ,040 -50. ,996 1. 00 39. ,49 E c

ATOM 14946 0 GLY E 114 -51. ,578 -14. 865 -49. ,783 1. 00 38. ,63 E 0

ATOM 14948 N THR E 115 -51. ,341 -16. ,242 -51. ,580 1. 00 35. ,01 E N

ATOM 14949 CA THR E 115 -51. ,414 -17. ,502 -50. ,854 1. 00 37. 30 E c

ATOM 14951 CB THR E 115 -52. ,741 -18. ,266 -51. ,171 1. 00 35. ,88 E c

ATOM 14953 OGl THR E 115 -53. 867 -17. ,469 -50. ,784 1. 00 40. ,55 E 0

ATOM 14955 CG2 THR E 115 -52. 808 -19. 623 -50. ,456 1. 00 29. ,52 E c

ATOM 14959 C THR E 115 -50. 210 -18. 366 -51. ,273 1. 00 35. ,14 E c

ATOM 14960 0 THR E 115 -50. 033 -18. ,655 -52. ,454 1. 00 34. ,05 E 0

ATOM 14962 N LEU E 116 -49. ,362 -18. ,765 -50. ,331 1. 00 39. ,33 E N

ATOM 14963 CA LEU E 116 -48. 267 -19. 693 -50. ,679 1. 00 39. ,29 E c

ATOM 14965 CB LEU E 116 -47. 018 -19. ,524 -49, ,797 1. 00 35. ,73 E c

ATOM 14968 CG LEU E 116 -45. 782 -20. 438 -50. .008 1. 00 35. ,92 E c

ATOM 14970 CDl LEU E 116 -45. 211 -20. ,456 -51. ,438 1. 00 31. ,15 E c

ATOM 14974 CD2 LEU E 116 -44. 677 -20. ,010 -49. ,046 1. 00 34. ,91 E c human fD_Fab

ATOM 14978 C LEU E 116 -48. 789 -21. ,108 -50. ,569 1.00 41. ,42 E C

ATOM 14979 0 LEU E 116 -49. 171 -21. ,546 -49. ,501 1.00 44. ,68 E 0

ATOM 14981 N VAL E 117 -48. 827 -21. ,814 -51.690 1.00 43. ,77 E N

ATOM 14982 CA VAL E 117 -49. 128 -23. 225 -51. ,684 1.00 39. ,78 E C

ATOM 14984 CB VAL E 117 -50. 098 -23. ,629 -52. 833 1.00 39. ,32 E C

ATOM 14986 CGl VAL E 117 -50. 198 -25. ,160 -52. 973 1.00 35. ,09 E c

ATOM 14990 CG2 VAL E 117 -51. 476 -23. ,029 -52. 612 1.00 33. ,99 E c

ATOM 14994 C VAL E 117 -47. 813 -23. ,950 -51. 847 1.00 41. ,25 E c

ATOM 14995 0 VAL E 117 -47. 117 -23. ,733 -52. 822 1.00 41. ,92 E 0

ATOM 14997 N THR E 118 -47. ,452 -24. ,781 -50. 872 1.00 44. ,17 E N

ATOM 14998 CA THR E 118 -46. ,302 -25. ,690 -51. 014 1.00 43. ,92 E c

ATOM 15000 CB THR E 118 -45. ,457 -25. ,744 -49. 743 1.00 39. ,82 E C

ATOM 15002 OGl THR E 118 -45. 150 -24. ,411 -49. 347 1.00 41. ,89 E 0

ATOM 15004 CG2 THR E 118 -44. ,171 -26. ,519 -49. 979 1.00 34. ,11 E C

ATOM 15008 C THR E 118 -46. 765 -27. ,122 -51. 327 1.00 44. ,43 E c

ATOM 15009 0 THR E 118 -47. 655 -27. ,657 -50. 661 1.00 41. ,73 E 0

ATOM 15011 N VAL E 119 -46. 139 -27. ,739 -52. 334 1.00 47, ,80 E N

ATOM 15012 CA VAL E 119 -46. 458 -29. ,110 -52. 703 1.00 47. ,06 E c

ATOM 15014 CB VAL E 119 -46. 756 -29. ,236 -54. 222 1.00 45. ,63 E c

ATOM 15016 CGl VAL E 119 -46. 876 -30. ,691 -54. 640 1.00 44. ,86 E c

ATOM 15020 CG2 VAL E 119 -48. 033 -28. ,496 -54. 577 1.00 47. ,38 E c

ATOM 15024 C VAL E 119 -45. 305 -30. ,042 -52. 316 1.00 47. ,73 E c

ATOM 15025 0 VAL E 119 -44. 262 -30. ,054 -52. 969 1.00 46. ,38 E 0

ATOM 15027 N SER E 120 -45. 506 -30. ,821 -51. 251 1.00 49. ,15 E N

ATOM 15028 CA SER E 120 -44. 473 -31. ,728 -50. 733 1.00 49. ,42 E c

ATOM 15030 CB SER E 120 -43. 504 -30. ,984 -49. 784 1.00 47. ,54 E c

ATOM 15033 OG SER E 120 -42. 550 -31. ,865 -49. 174 1.00 41. ,99 E 0

ATOM 15035 C SER E 120 -45. 060 -32. ,940 -50. 009 1.00 46. ,37 E c

ATOM 15036 0 SER E 120 -46. 167 -32. ,891 -49. 462 1.00 46. ,44 E 0

ATOM 15038 N SER E 121 -44. 291 -34. ,027 -49. 998 1.00 49. ,64 E N

ATOM 15039 CA SER E 121 -44. 607 -35. ,191 -49. 150 1.00 49. ,71 E c

ATOM 15041 CB SER E 121 -44. 002 -36. ,486 -49. 716 1.00 51. ,18 E c

ATOM 15044 OG SER E 121 -42. 582 -36. ,461 -49. 741 1.00 49. ,64 E 0

ATOM 15046 C SER E 121 -44. 177 -34. ,991 -47. ,694 1.00 46. ,18 E c

ATOM 15047 0 SER E 121 -44. 596 -35. ,747 -46. ,842 1.00 46. 66 E 0

ATOM 15049 N ALA E 122 -43. 373 -33. ,969 -47. ,395 1.00 46. ,06 E N

ATOM 15050 CA ALA E 122 -42. 976 -33. ,700 -46. ,013 1.00 45. ,55 E c

ATOM 15052 CB ALA E 122 -41. 806 -32. 751 -45. ,971 1.00 38. ,99 E c

ATOM 15056 C ALA E 122 -44. 136 -33. 148 -45. 163 1.00 48. ,52 E c

ATOM 15057 0 ALA E 122 -45. 089 -32. ,520 -45. 672 1.00 50. ,81 E 0

ATOM 15059 N SER E 123 -44. 033 -33. 365 -43. 857 1.00 48. ,54 E N

ATOM 15060 CA SER E 123 -45. 051 -32. ,914 -42. 923 1.00 47. ,58 E c

ATOM 15062 CB SER E 123 -45. 196 -33. ,925 -41. 763 1.00 52. ,59 E c

ATOM 15065 OG SER E 123 -45. 569 -35. ,217 -42. 225 1.00 51. ,67 E 0

ATOM 15067 C SER E 123 -44. 767 -31. ,533 -42. 325 1.00 47. ,84 E c

ATOM 15068 0 SER E 123 -43. 621 -31. ,073 -42. ,292 1.00 46, .20 E 0

ATOM 15070 N THR E 124 -45. 834 -30. ,903 -41. ,831 1.00 45, ,49 E N

ATOM 15071 CA THR E 124 -45. 761 -29. ,639 -41. ,104 1.00 45. .71 E c

ATOM 15073 CB THR E 124 -47. 157 -29. ,117 -40. ,701 1.00 44, ,96 E c

ATOM 15075 OGl THR E 124 -47. 999 -29. ,013 -41. ,854 1.00 51. .69 E 0

ATOM 15077 CG2 THR E 124 -47. 046 -27. ,762 -40. ,045 1.00 46, ,06 E c

ATOM 15081 C THR E 124 -44. 978 -29. ,758 -39. ,793 1.00 45. ,90 E c

ATOM 15082 0 THR E 124 -45. 248 -30. ,642 -38. 979 1.00 42. ,71 E 0

ATOM 15084 N LYS E 125 -44. 043 -28. ,831 -39. ,594 1.00 46.29 E N

ATOM 15085 CA LYS E 125 -43. 340 -28. ,668 -38. 336 1.00 44. ,38 E c

ATOM 15087 CB LYS E 125 -41. 917 -29. ,252 -38. ,421 1.00 50. ,21 E c

ATOM 15090 CG LYS E 125 -41. 441 -29. ,922 -37. ,114 1.00 53. ,82 E c

ATOM 15093 CD LYS E 125 -39. 992 -29. ,555 -36. ,714 1.00 53, .81 E c

ATOM 15096 CE LYS E 125 -39. 871 -29. ,173 -35. 209 1.00 55, ,45 E c

ATOM 15099 NZ LYS E 125 -38. 860 -28. ,081 -34. ,950 1.00 53, .92 E N

ATOM 15103 C LYS E 125 -43. 274 -27. ,179 -38. 001 1.00 42, ,78 E c

ATOM 15104 0 LYS E 125 -42. 865 -26. ,360 -38. 836 1.00 42, .26 E 0

ATOM 15106 N GLY E 126 -43. 681 -26. ,838 -36. 779 1.00 42, .44 E N

ATOM 15107 CA GLY E 126 -43. 591 -25. ,479 -36. 272 1.00 41, ,40 E c

ATOM 15110 C GLY E 126 -42. 166 -25. ,155 -35. ,848 1.00 39, .81 E c

ATOM 15111 0 GLY E 126 -41. 406 -26. ,042 -35. 465 1.00 41, ,35 E 0

ATOM 15113 N PRO E 127 -41. 794 -23. ,876 -35. 900 1.00 39, .16 E N

ATOM 15114 CA PRO E 127 -40. 442 -23. ,466 -35. 596 1.00 40, .96 E c human fD_Fab

ATOM 15116 CB PRO E 127 -40. 413 -22. 044 -36. ,133 1.00 37. ,18 E C

ATOM 15119 CG PRO E 127 -41. 748 -21. 562 -35. 901 1.00 35. ,16 E C

ATOM 15122 CD PRO E 127 -42. 639 -22. 717 -36. 221 1.00 39. ,03 E c

ATOM 15125 C PRO E 127 -40. 157 -23. ,434 -34. ,105 1.00 43. ,12 E c

ATOM 15126 O PRO E 127 -41. 058 -23. ,203 -33. 315 1.00 45. 66 E 0

ATOM 15127 N SER E 128 -38. 897 -23. 638 -33. 741 1.00 44. 39 E N

ATOM 15128 CA SER E 128 -38. 395 -23. 296 -32. 411 1.00 43. 86 E c

ATOM 15130 CB SER E 128 -37. 286 -24. 242 -31.939 1.00 47. 47 E c

ATOM 15133 OG SER E 128 -37. 761 -25. 541 -31. 642 1.00 51. 43 E 0

ATOM 15135 C SER E 128 -37. 822 -21. 893 -32. 541 1.00 42. 79 E c

ATOM 15136 O SER E 128 -37. 161 -21. ,585 -33. 534 1.00 46. ,06 E 0

ATOM 15138 N VAL E 129 -38. 063 -21. ,049 -31. ,540 1.00 44. ,43 E N

ATOM 15139 CA VAL E 129 -37. 590 -19. ,664 -31. ,561 1.00 44. ,41 E c

ATOM 15141 CB VAL E 129 -38. 762 -18. ,649 -31. ,434 1.00 39. 90 E c

ATOM 15143 CGI VAL E 129 -38. 262 -17. 237 -31. 682 1.00 36. ,35 E c

ATOM 15147 CG2 VAL E 129 -39. 852 -18. 986 -32. 421 1.00 33. ,72 E c

ATOM 15151 C VAL E 129 -36. 551 -19. 453 -30. 460 1.00 47. 66 E c

ATOM 15152 O VAL E 129 -36. 792 -19. 801 -29. 296 1.00 54. 26 E 0

ATOM 15154 N PHE E 130 -35. 385 -18. ,931 -30. ,843 1.00 47. ,05 E N

ATOM 15155 CA PHE E 130 -34. 258 -18. ,772 -29. ,928 1.00 43. ,47 E c

ATOM 15157 CB PHE E 130 -33. 126 -19. ,752 -30. ,261 1.00 40. ,82 E c

ATOM 15160 CG PHE E 130 -33. 563 -21. ,179 -30. ,267 1.00 41. ,74 E c

ATOM 15161 CDl PHE E 130 -34. 246 -21.708 -29. 172 1.00 40. ,97 E c

ATOM 15163 CEl PHE E 130 -34. 681 -23. 020 -29. 171 1.00 39. ,80 E c

ATOM 15165 CZ PHE E 130 -34. 430 -23. 820 -30. 277 1.00 41. 73 E c

ATOM 15167 CE2 PHE E 130 -33. 763 -23. ,294 -31. ,389 1.00 39. ,75 E c

ATOM 15169 CD 2 PHE E 130 -33. 328 -21. ,989 -31. 373 1.00 41. ,27 E c

ATOM 15171 C PHE E 130 -33. 757 -17. ,355 -30. Oil 1.00 44. ,94 E c

ATOM 15172 O PHE E 130 -33. 666 -16. ,805 -31. ,105 1.00 45. ,85 E 0

ATOM 15174 N PRO E 131 -33. 425 -16. 752 -28. ,858 1.00 46. ,44 E N

ATOM 15175 CA PRO E 131 -32. 928 -15. 392 -28. 922 1.00 45. ,89 E c

ATOM 15177 CB PRO E 131 -32. 941 -14. ,944 -27. 462 1.00 46. 30 E c

ATOM 15180 CG PRO E 131 -32. 762 -16. 187 -26. 697 1.00 45. 97 E c

ATOM 15183 CD PRO E 131 -33. 497 -17. ,241 -27. ,469 1.00 47. ,14 E c

ATOM 15186 C PRO E 131 -31. 524 -15. ,309 -29. 468 1.00 45. ,70 E c

ATOM 15187 O PRO E 131 -30. 707 -16. 190 -29. 213 1.00 50. 59 E 0

ATOM 15188 N LEU E 132 -31. 266 -14. 251 -30. 223 1.00 42. 84 E N

ATOM 15189 CA LEU E 132 -29. 920 -13. ,833 -30. ,540 1.00 42. 31 E c

ATOM 15191 CB LEU E 132 -29. 808 -13. 438 -32. 015 1.00 40. 68 E c

ATOM 15194 CG LEU E 132 -29. 990 -14. 520 -33. 073 1.00 37. ,84 E c

ATOM 15196 CDl LEU E 132 -30. 056 -13. ,861 -34. ,416 1.00 37. ,81 E c

ATOM 15200 CD2 LEU E 132 -28. 858 -15. ,538 -33. ,022 1.00 39. 85 E c

ATOM 15204 C LEU E 132 -29. 647 -12. ,636 -29. ,647 1.00 42. 83 E c

ATOM 15205 O LEU E 132 -29. 867 -11. ,507 -30.050 1.00 44. ,11 E 0

ATOM 15207 N ALA E 133 -29. 172 -12. 889 -28. ,425 1.00 48. ,49 E N

ATOM 15208 CA ALA E 133 -29. 076 -11.830 -27. 396 1.00 48. ,74 E c

ATOM 15210 CB ALA E 133 -28. 726 -12. ,416 -26. ,042 1.00 49. 33 E c

ATOM 15214 C ALA E 133 -28. 070 -10. ,771 -27. ,797 1.00 47. ,53 E c

ATOM 15215 O ALA E 133 -27. 074 -11. ,080 -28. ,430 1.00 49. ,29 E 0

ATOM 15217 N PRO E 134 -28. 343 -9. ,509 -27. ,458 1.00 50. ,85 E N

ATOM 15218 CA PRO E 134 -27. 299 -8. ,491 -27. ,644 1.00 56. ,04 E c

ATOM 15220 CB PRO E 134 -28. 057 -7. ,172 -27. ,473 1.00 50. ,36 E c

ATOM 15223 CG PRO E 134 -29. 269 -7. ,525 -26. ,655 1.00 49. ,31 E c

ATOM 15226 CD PRO E 134 -29. 601 -8. ,952 -26. ,922 1.00 46. ,01 E c

ATOM 15229 C PRO E 134 -26. 146 -8. ,653 -26. ,630 1.00 60. ,89 E c

ATOM 15230 0 PRO E 134 -26. 395 -8. ,896 -25. ,449 1.00 64. ,77 E 0

ATOM 15231 N SER E 135 -24. 905 -8. ,562 -27. ,104 1.00 65. ,06 E N

ATOM 15232 CA SER E 135 -23. 722 -8. ,676 -26. ,245 1.00 69. ,53 E c

ATOM 15234 CB SER E 135 -23. 103 -10. ,084 -26. ,356 1.00 72. ,75 E c

ATOM 15237 OG SER E 135 -22. 746 -10. ,426 -27. ,694 1.00 71. ,54 E 0

ATOM 15239 C SER E 135 -22. 706 -7. ,608 -26. ,625 1.00 73. ,24 E c

ATOM 15240 0 SER E 135 -22. 943 -6. ,810 -27. ,538 1.00 72. ,72 E 0

ATOM 15242 N SER E 136 -21. 581 -7. ,585 -25. ,915 1.00 78. ,71 E N

ATOM 15243 CA SER E 136 -20. 420 -6. .791 -26. ,322 1.00 78, ,29 E c

ATOM 15245 CB SER E 136 -19. 301 -6. .917 -25. ,282 1.00 74. ,84 E c

ATOM 15248 OG SER E 136 -18. 845 -8. ,252 -25. ,153 1.00 65. ,34 E 0

ATOM 15250 C SER E 136 -19. 914 -7. ,237 -27. ,695 1.00 81. ,40 E c

ATOM 15251 0 SER E 136 -19. 412 -6. ,428 -28. ,472 1.00 83. ,26 E 0 human fD_Fab

ATOM 15253 N LYS E 137 -20. 056 -8. 529 -27. ,986 1.00 81. ,50 E N

ATOM 15254 CA LYS E 137 -19. 713 -9. 075 -29. 306 1.00 79. ,99 E C

ATOM 15256 CB LYS E 137 -19. 438 -10. 587 -29. 231 1.00 77. ,51 E C

ATOM 15259 CG LYS E 137 -18. 103 -10. 967 -28. 583 1.00 75. ,44 E C

ATOM 15262 CD LYS E 137 -16. 902 -10. 609 -29. ,459 1.00 76. ,29 E C

ATOM 15265 CE LYS E 137 -15. 562 -10. 983 -28. ,784 1.00 77. ,03 E C

ATOM 15268 NZ LYS E 137 -15. 238 -10. 202 -27. ,549 1.00 80. ,28 E N

ATOM 15272 C LYS E 137 -20. 792 -8. 768 -30. ,362 1.00 77. ,56 E C

ATOM 15273 0 LYS E 137 -20. 709 -9. 251 -31. ,484 1.00 70. ,92 E 0

ATOM 15275 N SER E 138 -21. 798 -7. 970 -29. 995 1.00 78. ,95 E N

ATOM 15276 CA SER E 138 -22. 789 -7. 457 -30. 957 1.00 79. ,48 E C

ATOM 15278 CB SER E 138 -24. 072 -8. 307 -30. 937 1.00 75. ,67 E C

ATOM 15281 OG SER E 138 -25. 002 -7. 849 -29. 969 1.00 73. ,04 E 0

ATOM 15283 C SER E 138 -23. 117 -5. 956 -30. 777 1.00 79. ,89 E c

ATOM 15284 0 SER E 138 -24. 074 -5. 462 -31. ,361 1.00 77. ,34 E 0

ATOM 15286 N THR E 139 -22. 322 -5. 239 -29. ,982 1.00 81. ,72 E N

ATOM 15287 CA THR E 139 -22. 452 -3. 789 -29. ,861 1.00 82. ,85 E c

ATOM 15289 CB THR E 139 -22. 123 -3. 308 -28. 432 1.00 81. ,69 E c

ATOM 15291 OGl THR E 139 -23. 089 -3. 857 -27. 527 1.00 77. 64 E 0

ATOM 15293 CG2 THR E 139 -22. 154 -1. 773 -28. 328 1.00 80. ,18 E c

ATOM 15297 C THR E 139 -21.544 -3. 132 -30. 902 1.00 83. ,85 E c

ATOM 15298 0 THR E 139 -20. 576 -3. 737 -31. 352 1.00 83. ,96 E 0

ATOM 15300 N SER E 140 -21. 885 -1. 913 -31.309 1.00 83. ,58 E N

ATOM 15301 CA SER E 140 -21. 084 -1. 160 -32. ,284 1.00 83. ,87 E c

ATOM 15303 CB SER E 140 -21. 441 -1. 521 -33. ,717 1.00 85. ,00 E c

ATOM 15306 OG SER E 140 -20. 587 -0. 840 -34. ,617 1.00 84. ,84 E 0

ATOM 15308 C SER E 140 -21. 238 0. 342 -32. ,070 1.00 83. 43 E c

ATOM 15309 0 SER E 140 -22. 184 0. 965 -32. ,556 1.00 81. ,43 E 0

ATOM 15311 N GLY E 141 -20. 284 0. 913 -31. ,341 1.00 84. ,21 E N

ATOM 15312 CA GLY E 141 -20. 394 2. 280 -30. 862 1.00 82. ,92 E c

ATOM 15315 C GLY E 141 -21. 543 2. 348 -29. 872 1.00 84. ,25 E c

ATOM 15316 0 GLY E 141 -21. 506 1. 701 -28. 812 1.00 87. ,79 E 0

ATOM 15318 N GLY E 142 -22. 569 3. 116 -30. 236 1.00 79. ,54 E N

ATOM 15319 CA GLY E 142 -23. 799 3. 216 -29. ,456 1.00 76. ,02 E C

ATOM 15322 C GLY E 142 -24. 920 2. 316 -29. ,962 1.00 73. ,04 E C

ATOM 15323 0 GLY E 142 -26. 035 2. 383 -29. ,451 1.00 72. ,54 E 0

ATOM 15325 N THR E 143 -24. 616 1. 456 -30. ,940 1.00 70. ,21 E N

ATOM 15326 CA THR E 143 -25. 605 0. 558 -31. ,575 1.00 67. ,06 E C

ATOM 15328 CB THR E 143 -25. 472 0. 577 -33. ,126 1.00 68. ,59 E c

ATOM 15330 OGl THR E 143 -25. 777 1. 880 -33. ,639 1.00 69. ,29 E 0

ATOM 15332 CG2 THR E 143 -26. 396 -0. 439 -33. ,760 1.00 69. ,57 E c

ATOM 15336 C THR E 143 -25. 426 -0. 907 -31. ,179 1.00 64. ,60 E c

ATOM 15337 0 THR E 143 -24. 351 -1. 461 -31. ,371 1.00 65. ,39 E 0

ATOM 15339 N ALA E 144 -26. 476 -1. 538 -30. ,655 1.00 61. ,00 E N

ATOM 15340 CA ALA E 144 -26. 475 -2. 985 -30. ,397 1.00 56. ,86 E c

ATOM 15342 CB ALA E 144 -27. 022 -3. 269 -29. ,009 1.00 53. ,02 E c

ATOM 15346 C ALA E 144 -27. 306 -3. 747 -31. ,446 1.00 54. ,46 E c

ATOM 15347 0 ALA E 144 -28. 407 -3. 326 -31.800 1.00 55. ,06 E 0

ATOM 15349 N ALA E 145 -26. 791 -4. 877 -31. ,929 1.00 50. ,81 E N

ATOM 15350 CA ALA E 145 -27. 599 -5. 789 -32. ,745 1.00 47. ,46 E c

ATOM 15352 CB ALA E 145 -26. 782 -6. 382 -33. ,889 1.00 43. ,01 E c

ATOM 15356 C ALA E 145 -28. 187 -6. 903 -31. ,879 1.00 48. ,05 E c

ATOM 15357 0 ALA E 145 -27. 512 -7. 424 -30. ,992 1.00 49, .14 E 0

ATOM 15359 N LEU E 146 -29. 444 -7. 267 -32. ,144 1.00 45, .85 E N

ATOM 15360 CA LEU E 146 -30. 081 -8. 423 -31. ,503 1.00 45. .13 E c

ATOM 15362 CB LEU E 146 -30. 861 -7. 989 -30, ,253 1.00 44. .95 E c

ATOM 15365 CG LEU E 146 -31. 945 -6. 916 -30. ,478 1.00 46. ,29 E c

ATOM 15367 CDl LEU E 146 -33. 361 -7. 538 -30. ,463 1.00 45. .25 E c

ATOM 15371 CD2 LEU E 146 -31. 844 -5. 784 -29. ,464 1.00 47, ,71 E c

ATOM 15375 C LEU E 146 -31. 028 -9. 073 -32. ,504 1.00 43, .61 E c

ATOM 15376 0 LEU E 146 -31. 269 -8. 522 -33. ,567 1.00 43. .98 E 0

ATOM 15378 N GLY E 147 -31. 572 -10. 240 -32. ,170 1.00 44. ,19 E N

ATOM 15379 CA GLY E 147 -32. 478 -10. 909 -33. ,084 1.00 42, .51 E c

ATOM 15382 C GLY E 147 -33. 207 -12. 113 -32. ,536 1.00 41, .50 E c

ATOM 15383 0 GLY E 147 -33. 342 -12. 260 -31. ,333 1.00 37, ,47 E 0

ATOM 15385 N CYS E 148 -33. 690 -12. 957 -33. ,453 1.00 44, .40 E N

ATOM 15386 CA CYS E 148 -34. 356 -14. 235 -33. ,147 1.00 42, .56 E c

ATOM 15388 CB CYS E 148 -35. 874 -14. 038 -33. ,051 1.00 50, .28 E c human fD_Fab

ATOM 15391 SG CYS E 148 -36. .481 -13. 383 -31.472 1.00 55. 64 E S

ATOM 15393 C CYS E 148 -34. 056 -15. 262 -34. ,255 1.00 39. 89 E C

ATOM 15394 O CYS E 148 -34. ,200 -14. 954 -35. ,436 1.00 39. 62 E 0

ATOM 15396 N LEU E 149 -33. ,610 -16. 453 -33. 868 1.00 36. 49 E N

ATOM 15397 CA LEU E 149 -33. ,436 -17. 541 -34. 784 1.00 36. 54 E c

ATOM 15399 CB LEU E 149 -32. ,252 -18. 410 -34. ,334 1.00 39. 13 E c

ATOM 15402 CG LEU E 149 -31. ,945 -19. 675 -35. ,139 1.00 37. 71 E c

ATOM 15404 CDl LEU E 149 -31. ,556 -19. 344 -36. ,572 1.00 34. 43 E c

ATOM 15408 CD2 LEU E 149 -30. ,851 -20. 497 -34. ,450 1.00 39. 33 E c

ATOM 15412 C LEU E 149 -34. ,745 -18. 344 -34. 796 1.00 40. 43 E c

ATOM 15413 O LEU E 149 -35. ,142 -18. 935 -33. ,763 1.00 37. 84 E 0

ATOM 15415 N VAL E 150 -35. ,404 -18. 368 -35. ,962 1.00 39. 08 E N

ATOM 15416 CA VAL E 150 -36. ,653 -19. 125 -36. ,167 1.00 36. 48 E c

ATOM 15418 CB VAL E 150 -37. ,765 -18. 335 -36. 953 1.00 35. 71 E c

ATOM 15420 CGl VAL E 150 -39. 095 -19. 108 -36. 914 1.00 27. 11 E c

ATOM 15424 CG2 VAL E 150 -37. ,945 -16. 898 -36. 411 1.00 23. 78 E c

ATOM 15428 C VAL E 150 -36. ,274 -20. 360 -36. ,940 1.00 37. 23 E c

ATOM 15429 O VAL E 150 -35. ,995 -20. 304 -38. ,130 1.00 38. 84 E 0

ATOM 15431 N LYS E 151 -36. ,226 -21. 472 -36. 230 1.00 39. 70 E N

ATOM 15432 CA LYS E 151 -35. ,446 -22. 622 -36. ,629 1.00 40. 10 E c

ATOM 15434 CB LYS E 151 -34. ,339 -22. 752 -35. ,565 1.00 41. 90 E c

ATOM 15437 CG LYS E 151 -33. ,622 -24. 064 -35. 399 1.00 41. 48 E c

ATOM 15440 CD LYS E 151 -32. ,480 -24. 211 -36. ,315 1.00 41. 11 E c

ATOM 15443 CE LYS E 151 -31. ,499 -25. 198 -35. ,756 1.00 40. 01 E c

ATOM 15446 NZ LYS E 151 -30. ,737 -25. 814 -36. ,841 1.00 40. 23 E N

ATOM 15450 C LYS E 151 -36. ,345 -23. 867 -36.783 1.00 42. 38 E c

ATOM 15451 O LYS E 151 -37. 292 -24. 077 -36. 023 1.00 42. 48 E 0

ATOM 15453 N ASP E 152 -36. ,068 -24. 645 -37. ,830 1.00 42. 90 E N

ATOM 15454 CA ASP E 152 -36. ,657 -25. 963 -38. ,027 1.00 42. 45 E c

ATOM 15456 CB ASP E 152 -36. ,269 -26. 876 -36. 865 1.00 46. 08 E c

ATOM 15459 CG ASP E 152 -34. 838 -27. 268 -36. 915 1.00 44. 31 E c

ATOM 15460 ODl ASP E 152 -34. ,277 -27. 234 -38. ,032 1.00 44. 66 E 0

ATOM 15461 OD2 ASP E 152 -34. 292 -27. 628 -35. 849 1.00 48. 26 E 0

ATOM 15462 C ASP E 152 -38. 156 -25. 990 -38. 211 1.00 41. 34 E c

ATOM 15463 O ASP E 152 -38. 855 -26. 656 -37. 463 1.00 45. 48 E 0

ATOM 15465 N TYR E 153 -38. 639 -25. 291 -39. 231 1.00 42. 31 E N

ATOM 15466 CA TYR E 153 -40. 063 -25. 291 -39. ,561 1.00 42. 33 E c

ATOM 15468 CB TYR E 153 -40. 697 -23. 916 -39. 333 1.00 35. 78 E c

ATOM 15471 CG TYR E 153 -40. ,133 -22. 805 -40. ,204 1.00 36. 28 E c

ATOM 15472 CDl TYR E 153 -40. ,695 -22. 510 -41. ,442 1.00 35. 52 E c

ATOM 15474 CEl TYR E 153 -40. ,193 -21. 495 -42. 224 1.00 35. 55 E c

ATOM 15476 CZ TYR E 153 -39. ,108 -20. 740 -41. ,773 1.00 35. 22 E c

ATOM 15477 OH TYR E 153 -38. ,593 -19. 716 -42. ,549 1.00 34. 94 E 0

ATOM 15479 CE2 TYR E 153 -38. ,546 -21. 004 -40. 552 1.00 32. 65 E c

ATOM 15481 CD2 TYR E 153 -39. 053 -22. 033 -39. ,774 1.00 36. 08 E c

ATOM 15483 C TYR E 153 -40. 308 -25. 728 -40. ,997 1.00 44. 98 E c

ATOM 15484 O TYR E 153 -39. 433 -25. 614 -41. ,862 1.00 42. 97 E 0

ATOM 15486 N PHE E 154 -41. ,516 -26. 227 -41. ,234 1.00 46. 39 E N

ATOM 15487 CA PHE E 154 -41. 933 -26. 599 -42. 565 1.00 44. 10 E c

ATOM 15489 CB PHE E 154 -41. 472 -28. 027 -42. ,878 1.00 44. 72 E c

ATOM 15492 CG PHE E 154 -41.554 -28. 374 -44. ,334 1.00 45. ,45 E c

ATOM 15493 CDl PHE E 154 -40. ,665 -27. 813 -45. ,242 1.00 44. 39 E c

ATOM 15495 CEl PHE E 154 -40. ,749 -28. 109 -46. ,588 1.00 45. 60 E c

ATOM 15497 CZ PHE E 154 -41. ,731 -28. 974 -47. ,052 1.00 43. 70 E c

ATOM 15499 CE2 PHE E 154 -42. ,619 -29. 537 -46. ,165 1.00 45. 70 E c

ATOM 15501 CD2 PHE E 154 -42. ,533 -29. 231 -44. ,806 1.00 45. 80 E c

ATOM 15503 C PHE E 154 -43. ,434 -26. 492 -42. ,632 1.00 40. 75 E c

ATOM 15504 O PHE E 154 -44. ,083 -26. 826 -41. ,675 1.00 43. 98 E 0

ATOM 15506 N PRO E 155 -43. ,994 -25. 974 -43. ,740 1.00 40. 44 E N

ATOM 15507 CA PRO E 155 -43. ,353 -25. 371 -44. ,906 1.00 39. 76 E c

ATOM 15509 CB PRO E 155 -44. ,367 -25. 641 -46. ,018 1.00 35. 25 E c

ATOM 15512 CG PRO E 155 -45. ,684 -25. 505 -45. ,323 1.00 35. ,78 E c

ATOM 15515 CD PRO E 155 -45. ,464 -25. ,978 -43. ,893 1.00 41. ,17 E c

ATOM 15518 C PRO E 155 -43. ,163 -23. 878 -44. ,673 1.00 40. ,84 E c

ATOM 15519 O PRO E 155 -43. ,330 -23. ,416 -43. ,558 1.00 38. ,73 E 0

ATOM 15520 N GLU E 156 -42. ,798 -23. 133 -45. ,710 1.00 44. 32 E N

ATOM 15521 CA GLU E 156 -42. ,853 -21. ,687 -45. ,655 1.00 41. ,10 E c

ATOM 15523 CB GLU E 156 -42. ,109 -21. 096 -46. ,846 1.00 40. 35 E c human fD_Fab

ATOM 15526 CG GLU E 156 -40. ,612 -21. 136 -46. 753 1.00 40. ,17 E C

ATOM 15529 CD GLU E 156 -40. ,029 -19. 842 -46. 202 1.00 45. 92 E C

ATOM 15530 OEl GLU E 156 -40. ,206 -19. 548 -44. 971 1.00 37. ,91 E 0

ATOM 15531 OE2 GLU E 156 -39. ,397 -19. 120 -47. 020 1.00 45. ,84 E 0

ATOM 15532 C GLU E 156 -44. ,338 -21. 308 -45. 708 1.00 39. ,25 E C

ATOM 15533 0 GLU E 156 -45. ,146 -22. 096 -46. 174 1.00 40. ,68 E 0

ATOM 15535 N PRO E 157 -44. 704 -20. 092 -45. 264 1.00 39. ,96 E N

ATOM 15536 CA PRO E 157 -43. 912 -19. 039 -44. 673 1.00 38. ,16 E C

ATOM 15538 CB PRO E 157 -44. 522 -17. 798 -45. 325 1.00 36. ,51 E C

ATOM 15541 CG PRO E 157 -45. ,966 -18. 131 -45. ,495 1.00 35. ,12 E c

ATOM 15544 CD PRO E 157 -46. ,091 -19. 632 -45. ,463 1.00 37. ,74 E c

ATOM 15547 C PRO E 157 -44. 027 -18. 936 -43. ,149 1.00 38. ,17 E c

ATOM 15548 0 PRO E 157 -44. 887 -19. 598 -42. ,533 1.00 40. ,68 E 0

ATOM 15549 N VAL E 158 -43. ,136 -18. 130 -42. 566 1.00 38. ,69 E N

ATOM 15550 CA VAL E 158 -43. 309 -17. 544 -41. 231 1.00 42. ,27 E c

ATOM 15552 CB VAL E 158 -42. 185 -17. 911 -40. 195 1.00 38. ,54 E c

ATOM 15554 CGI VAL E 158 -42. 262 -19. 359 -39. 782 1.00 37. ,42 E c

ATOM 15558 CG2 VAL E 158 -40. 820 -17. 588 -40. 734 1.00 36. ,49 E c

ATOM 15562 C VAL E 158 -43. 274 -16. 038 -41. 409 1.00 44. ,56 E c

ATOM 15563 0 VAL E 158 -42. 601 -15. 548 -42. 307 1.00 46. ,50 E 0

ATOM 15565 N THR E 159 -43. 988 -15. 321 -40. 545 1.00 46. ,33 E N

ATOM 15566 CA THR E 159 -43. 831 -13. 875 -40. ,416 1.00 45. ,55 E c

ATOM 15568 CB THR E 159 -45. 183 -13. 155 -40. ,477 1.00 47. ,59 E c

ATOM 15570 OGl THR E 159 -46. 057 -13. 693 -39. ,477 1.00 50. ,73 E 0

ATOM 15572 CG2 THR E 159 -45. ,811 -13. 329 -41. 845 1.00 44. ,74 E c

ATOM 15576 C THR E 159 -43. 140 -13. 540 -39. ,096 1.00 45. ,28 E c

ATOM 15577 0 THR E 159 -43. 339 -14. 231 -38. 098 1.00 44. ,13 E 0

ATOM 15579 N VAL E 160 -42. 292 -12. 511 -39. 125 1.00 44. ,66 E N

ATOM 15580 CA VAL E 160 -41. 637 -12. 015 -37. 930 1.00 43. ,72 E c

ATOM 15582 CB VAL E 160 -40. 124 -12. 213 -37. 931 1.00 43. ,08 E c

ATOM 15584 CGI VAL E 160 -39. 578 -11. 839 -36. 547 1.00 35. ,94 E c

ATOM 15588 CG2 VAL E 160 -39. 764 -13. 667 -38. 322 1.00 41. ,76 E c

ATOM 15592 C VAL E 160 -41. 902 -10. 531 -37. 812 1.00 44. ,86 E c

ATOM 15593 0 VAL E 160 -41. 585 -9. 768 -38. ,724 1.00 47. ,59 E 0

ATOM 15595 N 5ER E 161 -42. ,479 -10. 116 -36. ,690 1.00 43. ,97 E N

ATOM 15596 CA SER E 161 -42. ,518 -8. 702 -36. ,367 1.00 45. ,11 E c

ATOM 15598 CB SER E 161 -43. 960 -8. 143 -36. ,352 1.00 41.96 E c

ATOM 15601 OG SER E 161 -44. ,757 -8. 675 -35. ,311 1.00 41. 78 E 0

ATOM 15603 C SER E 161 -41.755 -8. 459 -35. ,067 1.00 43. 65 E c

ATOM 15604 0 SER E 161 -41. 366 -9. 405 -34. ,373 1.00 44. 94 E 0

ATOM 15606 N TRP E 162 -41. 470 -7. 189 -34. ,804 1.00 45. 22 E N

ATOM 15607 CA TRP E 162 -40. 768 -6. 775 -33. ,603 1.00 47. 80 E c

ATOM 15609 CB TRP E 162 -39. 457 -6. 118 -34. ,005 1.00 45. ,82 E C

ATOM 15612 CG TRP E 162 -38. 440 -7. 130 -34. ,396 1.00 44. ,18 E C

ATOM 15613 CDl TRP E 162 -38. 133 -7. 556 -35. 659 1.00 44. 68 E C

ATOM 15615 NEl TRP E 162 -37. 150 -8. 517 -35. ,606 1.00 44. ,58 E N

ATOM 15617 CE2 TRP E 162 -36. ,807 -8. 724 -34. 295 1.00 43. .42 E c

ATOM 15618 CD2 TRP E 162 -37. ,607 -7. 868 -33. 507 1.00 44. ,16 E c

ATOM 15619 CE3 TRP E 162 -37. ,458 -7. 891 -32. ,116 1.00 43. ,69 E c

ATOM 15621 CZ3 TRP E 162 -36. 541 -8. 753 -31. 562 1.00 45. ,12 E c

ATOM 15623 CH2 TRP E 162 -35. ,751 -9. 589 -32. 370 1.00 45. ,12 E c

ATOM 15625 CZ2 TRP E 162 -35. 873 -9. 589 -33. 737 1.00 43. ,92 E c

ATOM 15627 C TRP E 162 -41. ,660 -5. 835 -32. 798 1.00 49. ,68 E c

ATOM 15628 0 TRP E 162 -42. 232 -4. 892 -33. 349 1.00 51. ,16 E 0

ATOM 15630 N ASN E 163 -41.801 -6. 106 -31. 500 1.00 53. ,01 E N

ATOM 15631 CA ASN E 163 -42. 675 -5. 297 -30. ,648 1.00 53. ,97 E c

ATOM 15633 CB ASN E 163 -42. 037 -3. 937 -30. 313 1.00 51. ,87 E c

ATOM 15636 CG ASN E 163 -40. ,787 -4. 071 -29. ,460 1.00 49. ,18 E c

ATOM 15637 ODl ASN E 163 -40. ,501 -5. 142 -28. ,916 1.00 49. ,55 E 0

ATOM 15638 ND2 ASN E 163 -40. ,035 -2. 984 -29. ,338 1.00 49. ,41 E N

ATOM 15641 C ASN E 163 -44. ,014 -5. 087 -31. ,336 1.00 56. ,38 E c

ATOM 15642 0 ASN E 163 -44. 478 -3. 964 -31.499 1.00 58. ,81 E 0

ATOM 15644 N SER E 164 -44. 600 -6. 199 -31. ,771 1.00 60. ,40 E N

ATOM 15645 CA SER E 164 -45. 935 -6. 243 -32. 373 1.00 56. .68 E c

ATOM 15647 CB SER E 164 -46. 989 -5. 994 -31.290 1.00 58. ,39 E c

ATOM 15650 OG SER E 164 -46. 728 -6. 806 -30. ,158 1.00 58. .46 E 0

ATOM 15652 C SER E 164 -46. 127 -5. 266 -33. 533 1.00 57. ,53 E c

ATOM 15653 0 SER E 164 -47. 212 -4. 734 -33. ,722 1.00 59. .61 E 0 human fD_Fab

ATOM 15655 N GLY E 165 -45. 072 -5. 040 -34. 309 1.00 58. ,86 E N

ATOM 15656 CA GLY E 165 -45. ,126 -4. 115 -35. 442 1.00 56. ,23 E C

ATOM 15659 C GLY E 165 -44. .628 -2. 717 -35. 134 1.00 54. ,50 E C

ATOM 15660 O GLY E 165 -44. ,381 -1. 941 -36. 053 1.00 54. ,64 E 0

ATOM 15662 N ALA E 166 -44. ,469 -2. 395 -33. 850 1.00 54. ,00 E N

ATOM 15663 CA ALA E 166 -44. ,033 -1. 054 -33. 417 1.00 55. ,32 E C

ATOM 15665 CB ALA E 166 -44. ,158 -0. 915 -31. 905 1.00 53. 26 E c

ATOM 15669 C ALA E 166 -42. ,604 -0. 720 -33. 868 1.00 56. 02 E c

ATOM 15670 O ALA E 166 -42. ,345 0. 385 -34. 319 1.00 56. 90 E 0

ATOM 15672 N LEU E 167 -41. 693 -1. 689 -33. 746 1.00 56. ,61 E N

ATOM 15673 CA LEU E 167 -40. ,311 -1. 537 -34. 176 1.00 52. ,46 E c

ATOM 15675 CB LEU E 167 -39. ,376 -2. 311 -33. 246 1.00 52. ,74 E c

ATOM 15678 CG LEU E 167 -37. ,891 -2. 313 -33. 620 1.00 53. ,74 E c

ATOM 15680 CDl LEU E 167 -37. ,341 -0. 893 -33. 643 1.00 53. ,52 E c

ATOM 15684 CD2 LEU E 167 -37. ,094 -3. 190 -32. 669 1.00 51. ,10 E c

ATOM 15688 C LEU E 167 -40. ,172 -2. 060 -35. 593 1.00 52. 53 E c

ATOM 15689 O LEU E 167 -40. ,277 -3. 262 -35. 826 1.00 54. ,01 E 0

ATOM 15691 N THR E 168 -39. 932 -1. 151 -36. 533 1.00 53. ,19 E N

ATOM 15692 CA THR E 168 -39. 698 -1. 514 -37. 933 1.00 53. 39 E c

ATOM 15694 CB THR E 168 -40. 872 -1. 021 -38. 868 1.00 52. ,69 E c

ATOM 15696 OGl THR E 168 -41.050 0. 396 -38. 765 1.00 47. ,07 E 0

ATOM 15698 CG2 THR E 168 -42. ,206 -1. 726 -38. 511 1.00 49. ,67 E c

ATOM 15702 C THR E 168 -38. ,335 -1. 028 -38. 453 1.00 54. ,70 E c

ATOM 15703 O THR E 168 -37. ,783 -1. 609 -39. 387 1.00 52. ,98 E 0

ATOM 15705 N SER E 169 -37. ,774 0. 013 -37. 833 1.00 56. ,76 E N

ATOM 15706 CA SER E 169 -36. ,515 0. 593 -38. 299 1.00 56. ,00 E C

ATOM 15708 CB SER E 169 -36. 395 2. 039 -37. 839 1.00 58. ,97 E C

ATOM 15711 OG SER E 169 -35. 263 2. 649 -38. 431 1.00 60. ,57 E 0

ATOM 15713 C SER E 169 -35. ,297 -0. 214 -37. 833 1.00 57. ,29 E C

ATOM 15714 O SER E 169 -35. ,180 -0. 543 -36. 650 1.00 60. ,54 E 0

ATOM 15716 N GLY E 170 -34. 406 -0. 534 -38. 775 1.00 53. ,64 E N

ATOM 15717 CA GLY E 170 -33. ,215 -1. 352 -38. 505 1.00 50. ,32 E c

ATOM 15720 C GLY E 170 -33. 398 -2. 848 -38. 708 1.00 48. ,46 E c

ATOM 15721 O GLY E 170 -32. 427 -3. 590 -38. 679 1.00 47. ,40 E 0

ATOM 15723 N VAL E 171 -34. 636 -3. 291 -38. 928 1.00 49. ,17 E N

ATOM 15724 CA VAL E 171 -34. 965 -4. 718 -38. 990 1.00 43. ,48 E c

ATOM 15726 CB VAL E 171 -36. 486 -4. 970 -38. 781 1.00 41. ,83 E c

ATOM 15728 CGI VAL E 171 -36. 825 -6. 445 -39. 002 1.00 36. ,93 E c

ATOM 15732 CG2 VAL E 171 -36. ,955 -4. 502 -37. 395 1.00 38, ,07 E c

ATOM 15736 C VAL E 171 -34. ,551 -5. 353 -40. 325 1.00 42. ,91 E c

ATOM 15737 O VAL E 171 -34. 893 -4. 848 -41. 393 1.00 41. ,82 E 0

ATOM 15739 N HIS E 172 -33. ,806 -6. 456 -40. 239 1.00 42. ,78 E N

ATOM 15740 CA HIS E 172 -33. ,438 -7. 271 -41. 385 1.00 40.35 E c

ATOM 15742 CB HIS E 172 -31. 935 -7. 251 -41. 622 1.00 41. 85 E c

ATOM 15745 CG HIS E 172 -31. ,412 -5. 939 -42. 123 1.00 45. ,68 E c

ATOM 15746 NDl HIS E 172 -31. 881 -5. 333 -43. 272 1.00 45. 82 E N

ATOM 15748 CEl HIS E 172 -31. ,214 -4. 207 -43. 475 1.00 48. ,77 E c

ATOM 15750 NE2 HIS E 172 -30. ,332 -4. 058 -42. 500 1.00 44. ,13 E N

ATOM 15752 CD2 HIS E 172 -30. ,433 -5. 131 -41.646 1.00 47. .57 E c

ATOM 15754 C HIS E 172 -33. ,892 -8. 685 -41. 083 1.00 39. ,09 E c

ATOM 15755 O HIS E 172 -33. ,325 -9. 353 -40. 222 1.00 45. ,19 E 0

ATOM 15757 N THR E 173 -34. ,951 -9. 117 -41. 762 1.00 40. ,29 E N

ATOM 15758 CA THR E 173 -35. ,514 -10. 456 -41. 619 1.00 38. ,82 E c

ATOM 15760 CB THR E 173 -37. ,050 -10. 404 -41. 556 1.00 41. ,76 E c

ATOM 15762 OGl THR E 173 -37. ,459 -9. 839 -40. 299 1.00 46. ,80 E 0

ATOM 15764 CG2 THR E 173 -37. ,696 -11. 803 -41. ,743 1.00 34. ,32 E c

ATOM 15768 C THR E 173 -35. ,050 -11. 200 -42. ,842 1.00 38. ,84 E c

ATOM 15769 O THR E 173 -35. ,458 -10. 862 -43. ,945 1.00 40. ,60 E 0

ATOM 15771 N PHE E 174 -34. ,168 -12. 178 -42. ,638 1.00 39. ,82 E N

ATOM 15772 CA PHE E 174 -33. ,458 -12. 837 -43. ,722 1.00 38. ,87 E c

ATOM 15774 CB PHE E 174 -32. ,173 -13. 464 -43. 188 1.00 38. ,65 E c

ATOM 15777 CG PHE E 174 -31. ,150 -12. 445 -42. 842 1.00 39. ,32 E c

ATOM 15778 CDl PHE E 174 -30. 379 -11.885 -43. 829 1.00 38. ,16 E c

ATOM 15780 CEl PHE E 174 -29. ,469 -10. 917 -43. 540 1.00 38. ,52 E c

ATOM 15782 CZ PHE E 174 -29. ,343 -10. 456 -42. 253 1.00 39, .61 E c

ATOM 15784 CE2 PHE E 174 -30. ,111 -10. 997 -41. ,248 1.00 40, ,02 E c

ATOM 15786 CD2 PHE E 174 -31. 025 -11. 975 -41. ,548 1.00 40. ,75 E c

ATOM 15788 C PHE E 174 -34. 306 -13. 867 -44. ,422 1.00 40. ,16 E c human fD_Fab

ATOM 15789 O PHE E 174 -35. ,165 -14. 509 -43. 786 1.00 43. ,48 E 0

ATOM 15791 N PRO E 175 -34. ,094 -14. 024 -45. 740 1.00 40. ,39 E N

ATOM 15792 CA PRO E 175 -34. ,791 -15. 104 -46. 452 1.00 39. ,78 E C

ATOM 15794 CB PRO E 175 -34. 222 -15. 037 -47. 890 1.00 34. 25 E C

ATOM 15797 CG PRO E 175 -33. 398 -13. 791 -47. 981 1.00 30. 23 E C

ATOM 15800 CD PRO E 175 -33. 228 -13. 203 -46. 614 1.00 33. 76 E C

ATOM 15803 C PRO E 175 -34. 513 -16. 476 -45. 824 1.00 42. 09 E c

ATOM 15804 O PRO E 175 -33. 398 -16. 735 -45. 372 1.00 43. 99 E 0

ATOM 15805 N ALA E 176 -35. 532 -17. 329 -45. 776 1.00 41.68 E N

ATOM 15806 CA ALA E 176 -35. 382 -18. 667 -45. 247 1.00 41. 93 E C

ATOM 15808 CB ALA E 176 -36. 738 -19. 366 -45. 191 1.00 44. ,98 E C

ATOM 15812 C ALA E 176 -34. 419 -19. 471 -46. 097 1.00 43. ,76 E c

ATOM 15813 O ALA E 176 -34. 403 -19. 334 -47. 333 1.00 43. 53 E 0

ATOM 15815 N VAL E 177 -33. 608 -20. 304 -45. 435 1.00 46. 19 E N

ATOM 15816 CA VAL E 177 -32. 763 -21. 290 -46. 119 1.00 43. ,01 E c

ATOM 15818 CB VAL E 177 -31. 275 -21. 215 -45. 699 1.00 44. ,44 E c

ATOM 15820 CGl VAL E 177 -30. 623 -19. 933 -46. 169 1.00 44. 14 E c

ATOM 15824 CG2 VAL E 177 -31. 108 -21. 385 -44. 186 1.00 49. 71 E c

ATOM 15828 C VAL E 177 -33. 271 -22. 661 -45. 770 1.00 44. ,43 E c

ATOM 15829 O VAL E 177 -33. 632 -22. 915 -44. 623 1.00 47. ,79 E 0

ATOM 15831 N LEU E 178 -33. 295 -23. 546 -46. 761 1.00 47. ,70 E N

ATOM 15832 CA LEU E 178 -33. 649 -24. 945 -46. 552 1.00 46. ,87 E c

ATOM 15834 CB LEU E 178 -34. 227 -25. 525 -47. 838 1.00 45. ,36 E c

ATOM 15837 CG LEU E 178 -34. 770 -26. 943 -47. 750 1.00 43. ,40 E c

ATOM 15839 CDl LEU E 178 -35. 871 -27. 046 -46. 732 1.00 40. ,87 E c

ATOM 15843 CD2 LEU E 178 -35. 239 -27. 326 -49. 145 1.00 46. 66 E c

ATOM 15847 C LEU E 178 -32. 421 -25. 748 -46. 091 1.00 49. 24 E c

ATOM 15848 O LEU E 178 -31. 450 -25. 941 -46. 842 1.00 51. 73 E 0

ATOM 15850 N GLN E 179 -32. 491 -26. 238 -44. 854 1.00 49. ,44 E N

ATOM 15851 CA GLN E 179 -31. 408 -27. 019 -44. 270 1.00 47. ,40 E c

ATOM 15853 CB GLN E 179 -31.574 -27. 118 -42. 751 1.00 50. ,25 E c

ATOM 15856 CG GLN E 179 -31. 584 -25. 753 -42. 017 1.00 52. ,28 E c

ATOM 15859 CD GLN E 179 -32. 158 -25. 846 -40. 598 1.00 52. ,34 E c

ATOM 15860 OEl GLN E 179 -33. 296 -26. 283 -40. 394 1.00 50. ,09 E 0

ATOM 15861 NE2 GLN E 179 -31. 369 -25. 433 -39. 621 1.00 54. ,31 E N

ATOM 15864 C GLN E 179 -31. 393 -28. 398 -44. 880 1.00 46. ,38 E c

ATOM 15865 O GLN E 179 -32. 368 -28. 818 -45. 500 1.00 47. ,93 E 0

ATOM 15867 N SER E 180 -30. 303 -29. 126 -44. 668 1.00 48. ,62 E N

ATOM 15868 CA SER E 180 -30. 142 -30. 469 -45. 239 1.00 51. ,02 E c

ATOM 15870 CB SER E 180 -28. 714 -30. 985 -45. 008 1.00 52. ,13 E c

ATOM 15873 OG SER E 180 -28. 365 -30. 989 -43. 633 1.00 54. ,71 E 0

ATOM 15875 C SER E 180 -31. 189 -31. 467 -44. 703 1.00 51. ,80 E c

ATOM 15876 0 SER E 180 -31.413 -32. 532 -45. ,298 1.00 49. 23 E 0

ATOM 15878 N SER E 181 -31. 845 -31. 088 -43. 603 1.00 53. ,37 E N

ATOM 15879 CA SER E 181 -32. 919 -31. 872 -42. 997 1.00 50. ,93 E c

ATOM 15881 CB SER E 181 -32. 994 -31. 555 -41.500 1.00 47. ,21 E c

ATOM 15884 OG SER E 181 -33. 195 -30. 164 -41. 288 1.00 44. ,29 E 0

ATOM 15886 C SER E 181 -34. 285 -31. 647 -43. 656 1.00 52. ,16 E c

ATOM 15887 0 SER E 181 -35. ,248 -32. ,311 -43. 292 1.00 51. ,44 E 0

ATOM 15889 N GLY E 182 -34. ,364 -30. 728 -44. 624 1.00 51. ,77 E N

ATOM 15890 CA GLY E 182 -35. 631 -30. 409 -45. 279 1.00 49. 13 E c

ATOM 15893 C GLY E 182 -36. ,536 -29. 552 -44. ,410 1.00 47. ,59 E c

ATOM 15894 0 GLY E 182 -37. ,755 -29. 536 -44. ,606 1.00 49. ,30 E 0

ATOM 15896 N LEU E 183 -35. 923 -28. 853 -43. ,449 1.00 45. ,18 E N

ATOM 15897 CA LEU E 183 -36. 621 -27. 918 -42. ,557 1.00 46. 88 E c

ATOM 15899 CB LEU E 183 -36. 479 -28. 319 -41. ,089 1.00 45. .17 E c

ATOM 15902 CG LEU E 183 -37. 085 -29. 671 -40. 660 1.00 43. .52 E c

ATOM 15904 CDl LEU E 183 -36. 721 -30. 030 -39. ,216 1.00 39. ,13 E c

ATOM 15908 CD 2 LEU E 183 -38. ,601 -29. 688 -40. ,867 1.00 37. .65 E c

ATOM 15912 C LEU E 183 -36. ,035 -26. ,543 -42. ,763 1.00 46. .90 E c

ATOM 15913 0 LEU E 183 -34. ,821 -26. 396 -42. ,924 1.00 45. .66 E 0

ATOM 15915 N TYR E 184 -36. 907 -25. 535 -42. ,776 1.00 44. .10 E N

ATOM 15916 CA TYR E 184 -36. 476 -24. ,155 -42. ,975 1.00 43. ,11 E c

ATOM 15918 CB TYR E 184 -37. 623 -23. ,310 -43. ,518 1.00 39. .07 E c

ATOM 15921 CG TYR E 184 -37. 931 -23. 663 -44. ,935 1.00 39. .14 E c

ATOM 15922 CDl TYR E 184 -37. ,152 -23. 164 -45. ,970 1.00 39. ,59 E c

ATOM 15924 CEl TYR E 184 -37. 405 -23. 498 -47. ,274 1.00 40. ,25 E c

ATOM 15926 CZ TYR E 184 -38. 451 -24. 355 -47. ,559 1.00 42. .02 E c human fD_Fab

ATOM 15927 OH TYR E 184 -38.720 -24. 689 -48. ,864 1.00 43. 93 E 0

ATOM 15929 CE2 TYR E 184 -39.234 -24. 868 -46. ,550 1.00 39. 10 E C

ATOM 15931 CD2 TYR E 184 -38.963 -24. 527 -45. ,241 1.00 37. 79 E C

ATOM 15933 C TYR E 184 -35.907 -23. 518 -41. ,718 1.00 39. 68 E c

ATOM 15934 O TYR E 184 -36.291 -23. 841 -40. ,606 1.00 38. 41 E 0

ATOM 15936 N SER E 185 -34.976 -22. 598 -41. 922 1.00 39. 51 E N

ATOM 15937 CA SER E 185 -34.478 -21. 788 -40. ,840 1.00 42. 68 E c

ATOM 15939 CB SER E 185 -33.253 -22. 414 -40. ,194 1.00 38. 93 E c

ATOM 15942 OG SER E 185 -32.982 -21.775 -38. ,967 1.00 44. 46 E 0

ATOM 15944 C SER E 185 -34.203 -20. 368 -41. ,304 1.00 41. 56 E c

ATOM 15945 O SER E 185 -33.850 -20. 112 -42. ,457 1.00 42. 36 E 0

ATOM 15947 N LEU E 186 -34.387 -19. 442 -40. ,374 1.00 43. 89 E N

ATOM 15948 CA LEU E 186 -34.361 -18. 025 -40. ,670 1.00 43. 11 E c

ATOM 15950 CB LEU E 186 -35.764 -17. 637 -41. ,194 1.00 42. 80 E c

ATOM 15953 CG LEU E 186 -36.299 -16. 192 -41. ,271 1.00 45. 18 E c

ATOM 15955 CDl LEU E 186 -37.274 -16. 048 -42. ,436 1.00 46. 65 E c

ATOM 15959 CD2 LEU E 186 -36.976 -15. 717 -39. ,997 1.00 39. 14 E c

ATOM 15963 C LEU E 186 -34.024 -17. 224 -39. ,419 1.00 44. 26 E c

ATOM 15964 O LEU E 186 -34.491 -17. 543 -38. ,340 1.00 43. 11 E 0

ATOM 15966 N SER E 187 -33.205 -16. 189 -39. 580 1.00 46. 72 E N

ATOM 15967 CA SER E 187 -32.925 -15. 242 -38. 518 1.00 40. 15 E c

ATOM 15969 CB SER E 187 -31.421 -15. 137 -38. 335 1.00 45. 47 E c

ATOM 15972 OG SER E 187 -30.939 -16. 321 -37. 706 1. 00 49. 51 E 0

ATOM 15974 C SER E 187 -33.539 -13. 877 -38. 850 1.00 38. 06 E c

ATOM 15975 O SER E 187 -33.574 -13. 470 -40. 008 1.00 36. 45 E 0

ATOM 15977 N SER E 188 -34.081 -13. 213 -37. ,834 1.00 40. 03 E N

ATOM 15978 CA SER E 188 -34.499 -11. 815 -37. 936 1.00 40. 19 E C

ATOM 15980 CB SER E 188 -35.993 -11. 647 -37. ,621 1.00 41. 28 E C

ATOM 15983 OG SER E 188 -36.536 -10. 428 -38. 156 1.00 42. 04 E 0

ATOM 15985 C SER E 188 -33.648 -11. 004 -36. ,958 1.00 40. 33 E C

ATOM 15986 O SER E 188 -33.587 -11. 335 -35. ,778 1.00 39. 03 E 0

ATOM 15988 N VAL E 189 -32.964 -9. 972 -37. ,456 1.00 42. 77 E N

ATOM 15989 CA VAL E 189 -32.134 -9. 120 -36. 604 1.00 43. 52 E c

ATOM 15991 CB VAL E 189 -30.670 -9. 174 -36. ,993 1.00 40. 39 E c

ATOM 15993 CGl VAL E 189 -30.158 -10. 626 -36. ,973 1.00 37. 95 E c

ATOM 15997 CG2 VAL E 189 -30.458 -8. 498 -38. ,349 1.00 43. 37 E c

ATOM 16001 C VAL E 189 -32.585 -7. 661 -36. ,641 1.00 45. 29 E c

ATOM 16002 O VAL E 189 -33.235 -7. 209 -37. ,582 1.00 46. 21 E 0

ATOM 16004 N VAL E 190 -32.246 -6. 937 -35. ,586 1.00 45. 19 E N

ATOM 16005 CA VAL E 190 -32.530 -5. 508 -35. ,496 1.00 46. 38 E c

ATOM 16007 CB VAL E 190 -33.926 -5. 248 -34. ,826 1.00 46. 10 E c

ATOM 16009 CGl VAL E 190 -33.939 -5. ,677 -33. ,376 1.00 39. ,76 E c

ATOM 16013 CG2 VAL E 190 -34.338 -3. ,789 -34. ,954 1.00 46. 87 E c

ATOM 16017 C VAL E 190 -31.373 -4. 828 -34. ,745 1. 00 48. 83 E c

ATOM 16018 O VAL E 190 -30.897 - 5 . 322 -33. ,719 1.00 46. 31 E 0

ATOM 16020 N THR E 191 -30.874 -3. 739 -35. ,313 1.00 49. 89 E N

ATOM 16021 CA THR E 191 -29.853 -2. 922 -34. ,679 1.00 51. 57 E c

ATOM 16023 CB THR E 191 -28.869 -2. 396 -35. ,744 1.00 53. 79 E c

ATOM 16025 OGl THR E 191 -29.600 -1. 788 -36. ,825 1.00 57. ,97 E 0

ATOM 16027 CG2 THR E 191 -28.016 -3. ,546 -36. ,284 1.00 45. ,86 E c

ATOM 16031 C THR E 191 -30.537 -1. ,774 -33. ,932 1.00 51. 33 E c

ATOM 16032 O THR E 191 -31.350 -1. ,072 -34. ,514 1.00 51. ,93 E 0

ATOM 16034 N VAL E 192 -30.230 -1. 615 -32. ,643 1.00 54. ,56 E N

ATOM 16035 CA VAL E 192 -30.857 -0. 591 -31. ,775 1.00 57. ,53 E c

ATOM 16037 CB VAL E 192 -31.825 -1. 216 -30. 732 1.00 53. ,04 E c

ATOM 16039 CGl VAL E 192 -33.122 -1. 700 -31.387 1.00 49. ,92 E c

ATOM 16043 CG2 VAL E 192 -31.140 -2. ,346 -29. ,983 1.00 51.65 E c

ATOM 16047 C VAL E 192 -29.774 0. ,211 -31.029 1.00 62. ,01 E c

ATOM 16048 O VAL E 192 -28.611 -0. 184 -31. ,030 1.00 62. ,45 E 0

ATOM 16050 N PRO E 193 -30.143 1. 352 -30. ,405 1.00 66. ,85 E N

ATOM 16051 CA PRO E 193 -29.224 2. 010 -29. ,461 1.00 65. ,53 E c

ATOM 16053 CB PRO E 193 -30.010 3. 258 -29. ,013 1.00 68. , 00 E c

ATOM 16056 CG PRO E 193 -31.041 3. 482 -30. ,076 1.00 68. ,49 E c

ATOM 16059 CD PRO E 193 -31.406 2. ,107 -30. ,547 1.00 69. ,60 E c

ATOM 16062 C PRO E 193 -28.879 1. ,121 -28. ,247 1.00 67. ,49 E c

ATOM 16063 O PRO E 193 -29.729 0. ,358 -27. ,768 1.00 65. ,45 E 0

ATOM 16064 N SER E 194 -27.642 1. 223 -27. ,760 1.00 69. ,91 E N

ATOM 16065 CA SER E 194 -27.185 0. ,409 -26. ,628 1.00 70. ,98 E c human fD_Fab

ATOM 16067 CB SER E 194 -25. 655 0 480 -26 481 1. 00 72 74 E C

ATOM 16070 OG SER E 194 -24. 975 0 064 -27 660 1.00 71 73 E 0

ATOM 16072 C SER E 194 -27. 862 0 865 -25 328 1. 00 71 93 E C

ATOM 16073 O SER E 194 -28. 322 0 039 -24 528 1. 00 68 54 E 0

ATOM 16075 N SER E 195 -27. 935 2 184 -25 134 1.00 74 66 E N

ATOM 16076 CA SER E 195 -28. 593 2 775 -23 951 1.00 76 11 E c

ATOM 16078 CB SER E 195 -28. 617 4 306 -24 059 1.00 76 98 E c

ATOM 16081 OG SER E 195 -29. 537 4 743 -25 050 1.00 75 27 E 0

ATOM 16083 C SER E 195 -30. 026 2 257 -23 739 1.00 77 62 E c

ATOM 16084 O SER E 195 -30. 494 2 145 -22 598 1.00 76 58 E 0

ATOM 16086 N SER E 196 -30. 701 1 937 -24 846 1. 00 78 37 E N

ATOM 16087 CA SER E 196 -32. 089 1 459 -24 828 1.00 78 61 E c

ATOM 16089 CB SER E 196 -32. 638 1 370 -26 254 1.00 80 46 E c

ATOM 16092 OG SER E 196 -32. 214 0 172 -26 891 1.00 82 63 E 0

ATOM 16094 C SER E 196 -32. 283 0 101 -24 141 1.00 78 18 E c

ATOM 16095 O SER E 196 -33. 376 -0 186 -23 644 1. 00 77 20 E 0

ATOM 16097 N LEU E 197 -31. 239 -0 730 -24 132 1.00 78 71 E N

ATOM 16098 CA LEU E 197 -31.301 -2 048 -23 490 1.00 78 92 E c

ATOM 16100 CB LEU E 197 -30. 001 -2 824 -23 708 1.00 76 86 E c

ATOM 16103 CG LEU E 197 -29. 780 -3 441 -25 094 1. 00 77 79 E c

ATOM 16105 CDl LEU E 197 -29. 481 -2 386 -26 139 1.00 77 33 E c

ATOM 16109 CD2 LEU E 197 -28. 648 -4 452 -25 044 1.00 78 58 E c

ATOM 16113 C LEU E 197 -31. 572 -1 895 -22 000 1.00 80 77 E c

ATOM 16114 O LEU E 197 -31.360 -0 817 -21 430 1.00 83 03 E 0

ATOM 16116 N GLY E 198 -32. 061 -2 958 -21 367 1.00 81 03 E N

ATOM 16117 CA GLY E 198 -32. 360 -2 915 -19 931 1.00 82 88 E c

ATOM 16120 C GLY E 198 -33. 615 -2 131 -19 551 1.00 84 83 E c

ATOM 16121 O GLY E 198 -34. 313 -2 505 -18 601 1.00 84 21 E 0

ATOM 16123 N THR E 199 -33. 888 -1 041 -20 279 1. 00 84 86 E N

ATOM 16124 CA THR E 199 -35. 095 -0 220 -20 095 1.00 83 16 E c

ATOM 16126 CB THR E 199 -34. 777 1 302 -20 297 1.00 82 11 E c

ATOM 16128 OGl THR E 199 -34. 628 1 605 -21 694 1.00 76 53 E 0

ATOM 16130 CG2 THR E 199 -33. 497 1 698 -19 560 1.00 83 04 E c

ATOM 16134 C THR E 199 -36. 213 -0 634 -21 071 1.00 83 45 E c

ATOM 16135 O THR E 199 -37. 265 -1 130 -20 651 1. 00 84 58 E 0

ATOM 16137 N GLN E 200 -35. 965 -0 408 -22 368 1.00 80 52 E N

ATOM 16138 CA GLN E 200 -36. 880 -0 777 -23 460 1. 00 77 13 E c

ATOM 16140 CB GLN E 200 -36. 551 0 058 -24 708 1.00 76 07 E c

ATOM 16143 CG GLN E 200 -37. 165 -0 401 -26 036 1. 00 76 05 E c

ATOM 16146 CD GLN E 200 -38. 647 -0 089 -26 163 1.00 72 58 E c

ATOM 16147 OEl GLN E 200 -39. 493 -0 854 -25 702 1. 00 69 01 E 0

ATOM 16148 NE2 GLN E 200 -38. 967 1 028 -26 821 1.00 69 57 E N

ATOM 16151 C GLN E 200 -36. 801 -2 273 -23 786 1.00 75 12 E c

ATOM 16152 O GLN E 200 -35. 738 -2 781 -24 131 1.00 74 83 E 0

ATOM 16154 N THR E 201 -37. 942 -2 954 -23 690 1. 00 72 40 E N

ATOM 16155 CA THR E 201 -38. 069 -4 391 -23 949 1.00 70 94 E C

ATOM 16157 CB THR E 201 -39. 354 -4 925 -23 246 1. 00 71 08 E c

ATOM 16159 OGl TH E 201 -39. 103 -5 082 -21 842 1.00 72 73 E 0

ATOM 16161 CG2 THR E 201 -39. 829 -6 253 -23 840 1. 00 70 44 E c

ATOM 16165 C THR E 201 -38. 169 -4 717 -25 452 1.00 69 66 E c

ATOM 16166 O THR E 201 -38. 828 -3 992 -26 198 1.00 68 68 E 0

ATOM 16168 N TYR E 202 -37. 528 -5 812 -25 883 1. 00 65 91 E N

ATOM 16169 CA TYR E 202 -37. 556 -6 234 -27 297 1.00 60 83 E c

ATOM 16171 CB TYR E 202 -36. 177 -6 133 -27 953 1. 00 60 60 E c

ATOM 16174 CG TYR E 202 -35. 683 -4 707 -28 135 1.00 59 45 E c

ATOM 16175 CDl TYR E 202 -36. 281 -3 856 -29 058 1.00 59 31 E c

ATOM 16177 CEl TYR E 202 -35. 832 -2 534 -29 221 1. 00 62 00 E c

ATOM 16179 CZ TYR E 202 -34. 770 -2 064 -28 450 1.00 61 79 E c

ATOM 16180 OH TYR E 202 -34. 321 -0 771 -28 607 1.00 59 24 E 0

ATOM 16182 CE2 TYR E 202 -34. 162 -2 896 -27 525 1. 00 60 21 E c

ATOM 16184 CD2 TYR E 202 -34. 618 -4 209 -27 372 1.00 61 08 E c

ATOM 16186 C TYR E 202 -38. 100 -7 652 -27 429 1. 00 56 05 E c

ATOM 16187 0 TYR E 202 -37. 538 -8 589 -26 869 1. 00 50 90 E 0

ATOM 16189 N ILE E 203 -39. 214 -7 781 -28 156 1.00 56 20 E N

ATOM 16190 CA ILE E 203 -39. 892 -9 059 -28 392 1.00 55 87 E c

ATOM 16192 CB ILE E 203 -41. 372 -9 064 -27 859 1.00 59 63 E c

ATOM 16194 CGI ILE E 203 -41. 508 -8 365 -26 500 1.00 62 86 E c

ATOM 16197 CDl ILE E 203 -42. 108 -6 947 -26 602 1. 00 64 93 E c human fD_Fab

ATOM 16201 CG2 ILE E 203 -41. .935 -10. 484 -27. 806 1.00 55. 53 E C

ATOM 16205 C ILE E 203 -39. ,999 -9. 326 -29. 900 1.00 52. 16 E C

ATOM 16206 O ILE E 203 -40. .398 -8. 435 -30. 668 1.00 49. 44 E 0

ATOM 16208 N CYS E 204 -39. ,673 -10. 546 -30. 326 1.00 50. 57 E N

ATOM 16209 CA CYS E 204 -39. .965 -10. 955 -31. ,701 1.00 48. 79 E C

ATOM 16211 CB CYS E 204 -38. .837 -11. 783 -32. 340 1.00 49. 89 E c

ATOM 16214 SG CYS E 204 -38. .492 -13. 348 -31. 588 1.00 49. 68 E s

ATOM 16216 C CYS E 204 -41. .274 -11. 716 -31.708 1.00 45. 55 E c

ATOM 16217 O CYS E 204 -41. .485 -12. 621 -30. 899 1.00 41.41 E 0

ATOM 16219 N ASN E 205 -42. ,168 -11. 331 -32. 617 1.00 43. 33 E N

ATOM 16220 CA ASN E 205 -43. ,442 -12. 024 -32. 761 1.00 44. 35 E c

ATOM 16222 CB ASN E 205 -44. ,637 -11. 047 -32. 844 1.00 47. 83 E c

ATOM 16225 CG ASN E 205 -44, .422 -9. 783 -32. ,041 1.00 44. 26 E c

ATOM 16226 ODl ASN E 205 -44. .085 -8. 736 -32. ,593 1.00 40. 27 E 0

ATOM 16227 ND2 ASN E 205 -44, .582 -9. 883 -30. ,735 1.00 40. 14 E N

ATOM 16230 C ASN E 205 -43. .394 -12. 892 -34. 014 1.00 41.52 E c

ATOM 16231 O ASN E 205 -43. ,392 -12. 391 -35. 130 1.00 40. 35 E 0

ATOM 16233 N VAL E 206 -43. ,331 -14. 194 -33. 800 1.00 39. 78 E N

ATOM 16234 CA VAL E 206 -43. ,178 -15. 156 -34. 862 1.00 40. 15 E c

ATOM 16236 CB VAL E 206 -42. ,091 -16. 196 -34. 499 1.00 38. 34 E c

ATOM 16238 CGI VAL E 206 -41, ,990 -17. 283 -35. ,578 1.00 31. 39 E c

ATOM 16242 CG2 VAL E 206 -40, .737 -15. 480 -34. ,241 1.00 36. 57 E c

ATOM 16246 C VAL E 206 -44, ,507 -15. 852 -35. 054 1.00 38. 50 E c

ATOM 16247 O VAL E 206 -45, .077 -16. 360 -34. ,100 1.00 37. 28 E 0

ATOM 16249 N ASN E 207 -45. ,017 -15. 851 -36. 279 1.00 40. 09 E N

ATOM 16250 CA ASN E 207 -46. ,214 -16. 636 -36. 613 1.00 41. 76 E c

ATOM 16252 CB ASN E 207 -47. ,436 -15. 776 -37. 009 1.00 44. 52 E c

ATOM 16255 CG ASN E 207 -48. ,762 -16. 591 -37. 020 1.00 46. 51 E c

ATOM 16256 ODl ASN E 207 -48. ,834 -17. 719 -36. 515 1.00 50. 24 E 0

ATOM 16257 ND2 ASN E 207 -49, ,802 -16. 013 -37. ,596 1.00 46. 55 E N

ATOM 16260 C ASN E 207 -45, .911 -17. 617 -37. ,729 1.00 43. 47 E c

ATOM 16261 O ASN E 207 -45. ,300 -17. 273 -38. 739 1.00 42. 50 E 0

ATOM 16263 N HIS E 208 -46. ,349 -18. 849 -37. 528 1.00 43. 40 E N

ATOM 16264 CA HIS E 208 -46.232 -19. 889 -38. 536 1.00 40. 37 E c

ATOM 16266 CB HIS E 208 -45. ,188 -20. 930 -38. 113 1.00 39. 47 E c

ATOM 16269 CG HIS E 208 -45. ,003 -22. 041 -39,098 1.00 40. 52 E c

ATOM 16270 NDl HIS E 208 -44. ,390 -21. 862 -40. 316 1.00 41. 16 E N

ATOM 16272 CEl HIS E 208 -44, .367 -23. 010 -40. 968 1.00 36. 57 E c

ATOM 16274 NE2 HIS E 208 -44, .930 -23. 931 -40. ,214 1.00 33. 68 E N

ATOM 16276 CD2 HIS E 208 -45. ,346 -23. 347 -39. ,044 1.00 41. 03 E c

ATOM 16278 C HIS E 208 -47. ,609 -20. 515 -38. ,716 1.00 39. 74 E c

ATOM 16279 O HIS E 208 -47. ,991 -21. 429 -37. 996 1.00 42. 76 E 0

ATOM 16281 N LYS E 209 -48. ,358 -20. 015 -39. ,689 1.00 39. 37 E N

ATOM 16282 CA LYS E 209 -49. ,765 -20. 406 -39. 846 1.00 42. 63 E c

ATOM 16284 CB LYS E 209 -50. ,439 -19. 573 -40. 932 1.00 43. 39 E c

ATOM 16287 CG LYS E 209 -50, .328 -18. 071 -40. 697 1.00 47. 27 E c

ATOM 16290 CD LYS E 209 -51. .673 -17. 402 -40. ,541 1.00 50. 06 E c

ATOM 16293 CE LYS E 209 -51. .626 -15. 965 -41. ,075 1.00 51. 31 E c

ATOM 16296 NZ LYS E 209 -51. ,447 -15. 931 -42. 558 1.00 51. 12 E N

ATOM 16300 C LYS E 209 -49. .991 -21. 878 -40. ,159 1.00 43. 44 E c

ATOM 16301 O LYS E 209 -50. ,961 -22. 464 -39. ,665 1.00 44. 93 E 0

ATOM 16303 N PRO E 210 -49. ,137 -22. 482 -41. ,010 1.00 43. 10 E N

ATOM 16304 CA PRO E 210 -49. ,374 -23. 891 -41. ,314 1.00 44. 49 E c

ATOM 16306 CB PRO E 210 -48. ,209 -24. 267 -42. ,230 1.00 43. 18 E c

ATOM 16309 CG PRO E 210 -47. .727 -22. 996 -42. ,777 1.00 44. 11 E c

ATOM 16312 CD PRO E 210 -47, .966 -21. 966 -41.737 1.00 43. 79 E c

ATOM 16315 C PRO E 210 -49, .401 -24. 800 -40. 078 1.00 45. 33 E c

ATOM 16316 O PRO E 210 -50, .112 -25. 792 -40. ,098 1.00 46. 92 E 0

ATOM 16317 N SER E 211 -48, .643 -24. 473 -39. 024 1.00 46. 26 E N

ATOM 16318 CA SER E 211 -48. ,668 -25. 271 -37. 798 1.00 45. 86 E c

ATOM 16320 CB SER E 211 -47. ,253 -25. 568 -37. ,312 1.00 49. 88 E c

ATOM 16323 OG SER E 211 -46, ,699 -24. 479 -36. ,585 1.00 53. 17 E 0

ATOM 16325 C SER E 211 -49, .470 -24. 620 -36. ,672 1.00 44. 90 E c

ATOM 16326 0 SER E 211 -49, ,497 -25. 148 -35. ,557 1.00 44. 62 E 0

ATOM 16328 N ASN E 212 -50, ,137 -23. 503 -36. ,972 1.00 47. 88 E N

ATOM 16329 CA ASN E 212 -50, .809 -22. 683 -35. ,976 1.00 49. 47 E c

ATOM 16331 CB ASN E 212 -52. ,078 -23. 389 -35. ,491 1.00 57. 80 E c

ATOM 16334 CG ASN E 212 -52. ,992 -23. 807 -36. ,638 1.00 62. 14 E c human fo_Fab

ATOM 16335 ODl ASN E 212 -53. ,684 -22. 975 -37. 226 1.00 64. 96 E 0

ATOM 16336 ND2 ASN E 212 -52. ,998 -25. 103 -36. 958 1.00 62. 35 E N

ATOM 16339 C ASN E 212 -49. ,890 -22. 337 -34. 797 1.00 49. 53 E C

ATOM 16340 O ASN E 212 -50. ,338 -22. 283 -33. 649 1.00 50. ,43 E 0

ATOM 16342 N THR E 213 -48. 609 -22. 095 -35. 095 1.00 50. ,21 E N

ATOM 16343 CA THR E 213 -47. 600 -21. 745 -34. 083 1.00 51. ,40 E C

ATOM 16345 CB THR E 213 -46. 205 -22. 356 -34. 426 1.00 52. 68 E C

ATOM 16347 OGl THR E 213 -46. ,203 -23. 771 -34. 195 1.00 53. 98 E 0

ATOM 16349 CG2 THR E 213 -45. 095 -21. 711 -33. 591 1.00 50. 79 E c

ATOM 16353 C THR E 213 -47. 407 -20. 245 -33. 990 1.00 49. 98 E c

ATOM 16354 O THR E 213 -47. 065 -19. 618 -34. 971 1.00 48. 94 E 0

ATOM 16356 N LYS E 214 -47. 626 -19. 682 -32. 808 1.00 54. ,80 E N

ATOM 16357 CA LYS E 214 -47. ,356 -18. 274 -32. 532 1.00 54. ,83 E c

ATOM 16359 CB LYS E 214 -48. ,678 -17. 561 -32. 265 1.00 53. ,80 E c

ATOM 16362 CG LYS E 214 -48. ,602 -16. 069 -32. 290 1.00 58. ,18 E c

ATOM 16365 CD LYS E 214 -50. ,006 -15. 461 -32. 405 1.00 63. ,88 E c

ATOM 16368 CE LYS E 214 -50. 526 -15. 438 -33. 849 1.00 68. 16 E c

ATOM 16371 NZ LYS E 214 -49. ,784 -14. 462 -34. 723 1.00 71. 33 E N

ATOM 16375 C LYS E 214 -46. 436 -18. 179 -31. 313 1.00 55. 18 E c

ATOM 16376 0 LYS E 214 -46. 785 -18. 643 -30. 230 1.00 56. 04 E 0

ATOM 16378 N VAL E 215 -45. ,251 -17. 607 -31. 494 1.00 54. ,83 E N

ATOM 16379 CA VAL E 215 -44. ,337 -17. 439 -30. 385 1.00 53. ,31 E c

ATOM 16381 CB VAL E 215 -43. ,073 -18. 283 -30. 563 1.00 54. ,42 E c

ATOM 16383 CGI VAL E 215 -42. ,072 -18. 002 -29. 440 1.00 55. ,46 E c

ATOM 16387 CG2 VAL E 215 -43. ,445 -19. 763 -30. 591 1.00 54. 22 E c

ATOM 16391 C VAL E 215 -44. ,007 -15. 975 -30. 249 1.00 53. 37 E c

ATOM 16392 O VAL E 215 -43. ,828 -15. 286 -31. 257 1.00 53. 02 E 0

ATOM 16394 N ASP E 216 -43. 968 -15. 509 -28. 997 1.00 53. 54 E N

ATOM 16395 CA ASP E 216 -43. 490 -14. 169 -28. 668 1.00 55. 24 E c

ATOM 16397 CB ASP E 216 -44. ,598 -13. 347 -27. 993 1.00 58. ,70 E c

ATOM 16400 CG ASP E 216 -45. ,693 -12. ,928 -28. 965 1.00 58. 52 E c

ATOM 16401 ODl ASP E 216 -45. ,387 -12. ,168 -29. 912 1.00 52. 67 E 0

ATOM 16402 OD2 ASP E 216 -46. ,856 -13. 359 -28. 776 1.00 62. 66 E 0

ATOM 16403 C ASP E 216 -42. ,301 -14. 358 -27. 749 1.00 54. ,53 E c

ATOM 16404 O ASP E 216 -42. ,455 -14. 920 -26. 669 1.00 56. 17 E 0

ATOM 16406 N LYS E 217 -41. ,118 -13. 925 -28. 182 1.00 52. 83 E N

ATOM 16407 CA LYS E 217 -39. ,896 -14. 209 -27. 446 1.00 53. 38 E c

ATOM 16409 CB LYS E 217 -38. ,953 -15. ,050 -28. 317 1.00 56. 80 E c

ATOM 16412 CG LYS E 217 -37. 964 -15. ,905 -27. 551 1.00 59. ,81 E c

ATOM 16415 CD LYS E 217 -38. 686 -16. ,959 -26. 695 1.00 65. ,55 E c

ATOM 16418 CE LYS E 217 -37. 793 -18. ,168 -26. 439 1.00 64. ,97 E c

ATOM 16421 NZ LYS E 217 -38. 280 -19. ,024 -25. 323 1.00 65. ,51 E N

ATOM 16425 C LYS E 217 -39. 232 -12. ,914 -27. 037 1.00 51. ,71 E c

ATOM 16426 0 LYS E 217 -38. ,926 -12. ,076 -27. 885 1.00 48. ,71 E 0

ATOM 16428 N LYS E 218 -39. 021 -12. ,732 -25. 736 1.00 56. ,70 E N

ATOM 16429 CA LYS E 218 -38. ,284 -11. ,561 -25. 249 1.00 58. ,32 E c

ATOM 16431 CB LYS E 218 -38. ,607 -11. ,243 -23. 785 1.00 61. ,97 E c

ATOM 16434 CG LYS E 218 -38. ,118 -9. ,846 -23. ,324 1.00 62. ,61 E c

ATOM 16437 CD LYS E 218 -38. ,562 -9. 553 -21. ,889 1.00 63. ,90 E c

ATOM 16440 CE LYS E 218 -37. 693 -8. 507 -21. ,193 1.00 64. ,46 E c

ATOM 16443 NZ LYS E 218 -38. 039 -8. 363 -19. ,732 1.00 62. ,97 E N

ATOM 16447 C LYS E 218 -36. 798 -11. 812 -25. 449 1.00 58. ,16 E c

ATOM 16448 0 LYS E 218 -36. ,280 -12. ,867 -25. ,073 1.00 58. ,94 E 0

ATOM 16450 N VAL E 219 -36. ,129 -10. ,851 -26. 077 1.00 55. ,99 E N

ATOM 16451 CA VAL E 219 -34. ,708 -10. ,953 -26. 355 1.00 56. ,34 E c

ATOM 16453 CB VAL E 219 -34. ,356 -10. ,486 -27. ,816 1.00 51.58 E c

ATOM 16455 CGI VAL E 219 -32. ,854 -10. ,553 -28. ,048 1.00 40. ,20 E c

ATOM 16459 CG2 VAL E 219 -35. ,088 -11. ,316 -28. ,849 1.00 47. ,73 E c

ATOM 16463 C VAL E 219 -33. ,972 -10. ,057 -25. ,373 1.00 56. ,23 E c

ATOM 16464 0 VAL E 219 -33. ,918 -8. ,843 -25. ,567 1.00 55. ,92 E 0

ATOM 16466 N GLU E 220 -33. ,392 -10. ,651 -24. 332 1.00 59. ,40 E N

ATOM 16467 CA GLU E 220 -32. ,670 -9. ,869 -23. ,330 1.00 62. ,60 E c

ATOM 16469 CB GLU E 220 -33. ,336 -9. ,938 -21. ,954 1.00 65. ,31 E c

ATOM 16472 CG GLU E 220 -33. ,886 -11. ,279 -21. ,507 1.00 65. ,62 E c

ATOM 16475 CD GLU E 220 -34. ,891 -11. ,093 -20. ,411 1.00 67. ,44 E c

ATOM 16476 OEl GLU E 220 -34. ,886 -9, ,998 -19. 824 1.00 70. ,23 E 0

ATOM 16477 OE2 GLU E 220 -35. ,700 -12. ,009 -20. ,145 1.00 71. ,88 E 0

ATOM 16478 C GLU E 220 -31. ,186 -10. ,221 -23. 251 1.00 63. ,25 E c human fD _Fab

ATOM 16479 O GLU E 220 -30. .800 -11. 372 -23. ,521 1.00 60.83 E 0

ATOM 16481 N PRO E 221 -30. .351 -9. 226 -22. ,877 1.00 63.87 E N

ATOM 16482 CA PRO E 221 -28. .906 -9. 430 -22. ,677 1.00 66.31 E C

ATOM 16484 CB PRO E 221 -28. .395 -8. 062 -22. ,229 1.00 64.87 E C

ATOM 16487 CG PRO E 221 -29. ,495 -7. 088 -22. ,497 1.00 65.30 E c

ATOM 16490 CD PRO E 221 -30. .775 -7. 836 -22. ,619 1.00 62.83 E c

ATOM 16493 C PRO E 221 -28, .574 -10. 494 -21. 622 1.00 69.59 E c

ATOM 16494 O PRO E 221 -29. .358 -10. 708 -20. ,688 1.00 69.89 E 0

ATOM 16495 N LYS E 222 -27. .411 -11. 139 -21. 783 1.00 73.55 E N

ATOM 16496 CA LYS E 222 -26. .940 -12. 216 -20. 885 1.00 74.71 E c

ATOM 16498 CB LYS E 222 -26. .621 -13. 494 -21. 693 1.00 78.51 E c

ATOM 16501 CG LYS E 222 -27. .563 -13. 761 -22. 882 1.00 79.79 E c

ATOM 16504 CD LYS E 222 -27. ,561 -15. 240 -23. ,313 1.00 78.90 E c

ATOM 16507 CE LYS E 222 -28. ,829 -15. 619 -24. ,108 1.00 78.37 E c

ATOM 16510 NZ LYS E 222 -29. ,402 -16. 937 -23. 669 1.00 75.74 E N

ATOM 16514 C LYS E 222 -25, .684 -11. 786 -20. 125 1.00 75.22 E C

ATOM 16515 O LYS E 222 -24. .893 -10. 970 -20. ,624 1.00 76.21 E 0

ATOM 16518 CA ASP D 1 -52. .112 -16. 021 -76. ,658 1.00 45.76 D c

ATOM 16520 CB ASP D 1 -51. .455 -16. 830 -75. ,535 1.00 48.98 D c

ATOM 16523 CG ASP D 1 -52. ,464 -17. 516 -74. 635 1.00 52.75 D c

ATOM 16524 ODl ASP D 1 -53. ,589 -17. 792 -75. ,119 1.00 54.18 D 0

ATOM 16525 002 ASP D 1 -52. ,118 -17. 788 -73. 452 1.00 51.71 D 0

ATOM 16526 C ASP D 1 -51. ,066 -15. 048 -77. ,219 1.00 44.89 D c

ATOM 16527 0 ASP D 1 -50. ,159 -15. 449 -77. 931 1.00 49.36 D 0

ATOM 16528 N ILE D 2 -51. .172 -13. 777 -76. ,854 1.00 42.94 D N

ATOM 16529 CA ILE D 2 -50. .150 -12. 776 -77. ,194 1.00 41.01 D c

ATOM 16531 CB ILE D 2 -50. .684 -11. 337 -76. ,998 1.00 35.46 D c

ATOM 16533 CGI ILE D 2 -51. ,889 -11. 091 -77. ,920 1.00 35.57 D c

ATOM 16536 CDl ILE D 2 -52. ,607 -9. 743 -77. ,701 1.00 34.85 D c

ATOM 16540 CG2 ILE D 2 -49. ,596 -10. 327 -77. ,255 1.00 32.35 D c

ATOM 16544 C ILE D 2 -48. ,857 -12. 958 -76. ,377 1.00 43.16 D c

ATOM 16545 0 ILE D 2 -48. ,893 -13. 222 -75. ,170 1.00 46.09 D 0

ATOM 16547 N GLN D 3 -47. ,718 -12. 824 -77. ,057 1.00 46.33 D N

ATOM 16548 CA GLN D 3 -46. .406 -13. 005 -76.436 1.00 45.44 D c

ATOM 16550 CB GLN D 3 -45. .416 -13. 787 -77. ,321 1.00 52.61 D c

ATOM 16553 CG GLN D 3 -45. .999 -14. 633 -78. ,437 1.00 59.09 D c

ATOM 16556 CD GLN D 3 -46. .833 -15. 749 -77. ,923 1.00 60.95 D c

ATOM 16557 OEl GLN D 3 -46. .544 -16. 310 -76.865 1.00 63.22 D 0

ATOM 16558 NE2 GLN D 3 -47. ,884 -16. 091 -78. ,664 1.00 63.18 D N

ATOM 16561 C GLN D 3 -45. ,802 -11. 641 -76. ,206 1.00 41.99 D c

ATOM 16562 0 GLN D 3 -46. ,034 -10. 729 -76. ,977 1.00 40.91 D 0

ATOM 16564 N VAL D 4 -45. ,005 -11. 527 -75. ,153 1.00 41.30 D N

ATOM 16565 CA VAL D 4 -44. .338 -10. ,287 -74. ,812 1.00 41.54 D c

ATOM 16567 CB VAL D 4 -44. .961 -9. ,611 -73, ,560 1.00 39.07 D C

ATOM 16569 CGI VAL D 4 -44, .385 -8. ,227 -73. ,376 1.00 33.94 D c

ATOM 16573 CG2 VAL D 4 -46. .482 -9. ,547 -73, ,668 1.00 42.19 D c

ATOM 16577 C VAL D 4 -42. .926 -10. ,664 -74. ,491 1.00 39.69 D c

ATOM 16578 0 VAL D 4 -42. .695 -11.703 -73. .888 1.00 39.55 D 0

ATOM 16580 N THR D 5 -41. .984 -9. 829 -74. ,915 1.00 39.77 D N

ATOM 16581 CA THR D 5 -40. .581 -10. 070 -74. ,660 1.00 39.61 D c

ATOM 16583 CB THR D 5 -39. ,833 -10. 517 -75. ,954 1.00 40.46 D c

ATOM 16585 OGl THR D 5 -38. .467 -10. ,807 -75. ,637 1.00 49.32 D 0

ATOM 16587 CG2 THR D 5 -39. .895 -9. ,478 -77. ,027 1.00 41.92 D c

ATOM 16591 C THR D 5 -40, ,013 -8. ,828 -73. ,989 1.00 34.02 D c

ATOM 16592 0 THR D 5 -39, .915 -7. ,773 -74. ,604 1.00 28.83 D 0

ATOM 16594 N GLN D 6 -39, .680 -8. ,975 -72. ,701 1.00 33.46 D N

ATOM 16595 CA GLN D 6 -39. .178 -7. ,876 -71. .866 1.00 33.72 D c

ATOM 16597 CB GLN D 6 -39. .677 -7. ,988 -70. ,405 1.00 28.74 D c

ATOM 16600 CG GLN D 6 -39. .311 -6. ,776 -69. ,554 1.00 31.16 D c

ATOM 16603 CD GLN D 6 -40. .178 -6. ,547 -68. ,315 1.00 26.09 D c

ATOM 16604 OEl GLN D 6 -41. .232 -7. ,129 -68. .159 1.00 23.29 D 0

ATOM 16605 NE2 GLN D 6 -39. .720 -5. ,671 -67. .438 1.00 24.43 D N

ATOM 16608 C GLN D 6 -37. .660 -7. ,876 -71. .879 1.00 34.70 D c

ATOM 16609 0 GLN D 6 -37. .037 -8. 927 -71.909 1.00 34.47 D 0

ATOM 16611 N SER D 7 -37, .079 -6. 684 -71.813 1.00 33.82 D N

ATOM 16612 CA SER D 7 -35, .626 -6. 536 -71. ,804 1.00 32.43 D c

ATOM 16614 CB SER D 7 -35, .120 -6. ,593 -73. ,250 1.00 35.43 D c

ATOM 16617 OG SER D 7 -33, .718 -6. ,445 -73. ,326 1.00 40.13 D 0 human fD_Fab

ATOM 16619 C SER D 7 -35. 208 - 5 . ,220 -71. ,106 1.00 31. ,31 D C

ATOM 16620 O SER D 7 -35. ,920 -4. ,226 -71. ,154 1.00 34. ,38 D 0

ATOM 16622 N PRO D 8 -34. 066 - 5 . ,221 -70. ,415 1.00 31.16 D N

ATOM 16623 CA PRO D 8 -33 . ,188 -6. ,355 -70. ,147 1.00 33 . ,46 D C

ATOM 16625 CB PRO D 8 -31.872 - 5 . ,677 -69. ,740 1.00 32. ,48 D C

ATOM 16628 CG PRO D 8 -32. ,309 -4. ,388 -69. ,103 1.00 23. ,95 D C

ATOM 16631 CD PRO D 8 -33. ,572 -3. .979 -69. .792 1.00 28. , 00 D c

ATOM 16634 C PRO D 8 -33. ,727 -7. ,227 -69. ,007 1.00 32. ,19 D c

ATOM 16635 O PRO D 8 -34. ,779 -6. ,950 -68. ,432 1.00 36. ,14 D 0

ATOM 16636 N SER D 9 -32. 991 -8. ,265 -68. ,669 1.00 35. ,24 D N

ATOM 16637 CA SER D 9 -33. 374 -9. ,106 -67. ,556 1.00 33. ,15 D c

ATOM 16639 CB SER D 9 -32. 801 -10. ,497 -67. 747 1.00 37. ,14 D c

ATOM 16642 OG SER D 9 -31. ,449 -10. ,492 -67. ,439 1.00 46. , 99 D 0

ATOM 16644 C SER D 9 -32. 966 -8. ,503 -66. ,204 1.00 31. ,51 D c

ATOM 16645 O SER D 9 -33. , 666 -8. ,678 -65. ,184 1.00 29. ,10 D 0

ATOM 16647 N SER D 10 -31. ,838 -7. ,790 -66. ,193 1.00 33. ,95 D N

ATOM 16648 CA SER D 10 -31. 394 -7. ,045 -65. ,018 1.00 30. ,90 0 c

ATOM 16650 CB SER D 10 -30. ,657 -7. .939 -64. ,008 1.00 36. ,72 D c

ATOM 16653 OG SER D 10 -29. ,499 -8. ,551 -64. ,560 1.00 39. ,79 D 0

ATOM 16655 C SER D 10 -30. 500 - 5 . ,908 -65. ,444 1.00 34. ,81 D c

ATOM 16656 O SER D 10 -29. ,937 - 5 . ,909 -66. ,546 1.00 38. 94 D 0

ATOM 16658 N LEU D 11 -30. ,420 -4. ,911 -64. ,576 1.00 36. 91 D N

ATOM 16659 CA LEU D 11 -29. ,573 -3. ,768 -64. ,789 1.00 34. ,54 D c

ATOM 16661 CB LEU D 11 -30. ,264 -2. ,719 -65. ,693 1.00 36. ,11 D c

ATOM 16664 CG LEU D 11 -31. ,416 -1. ,836 -65. ,164 1.00 31. ,73 D c

ATOM 16666 CDl LEU D 11 -30. 954 -0. ,630 -64. ,365 1.00 26. ,78 D c

ATOM 16670 CD2 LEU D 11 -32. 314 -1. ,361 -66. ,322 1.00 22. ,55 D c

ATOM 16674 C LEU D 11 -29. 209 -3. ,152 -63. ,451 1.00 33. ,59 D c

ATOM 16675 O LEU D 11 -29. ,850 -3. ,416 -62. ,448 1.00 30.13 D 0

ATOM 16677 N SER D 12 -28. ,189 -2. ,308 -63. ,478 1.00 36. 30 D N

ATOM 16678 CA SER D 12 -27. ,687 -1. ,602 -62. ,313 1.00 37. ,59 D c

ATOM 16680 CB SER D 12 -26. ,418 -2, ,289 -61. ,802 1.00 41. ,83 D c

ATOM 16683 OG SER D 12 -25. ,822 -1. ,555 -60. ,763 1.00 48. ,18 D 0

ATOM 16685 C SER D 12 -27. ,386 -0. ,171 -62. ,724 1.00 36. ,59 D c

ATOM 16686 O SER D 12 -26. ,781 0. ,067 -63. ,755 1.00 38. ,68 D 0

ATOM 16688 N ALA D 13 -27. 831 0, ,784 -61.928 1.00 35. ,81 D N

ATOM 16689 CA ALA D 13 -27. 606 2. ,180 -62. ,231 1.00 35. ,53 D c

ATOM 16691 CB ALA D 13 -28. 742 2, ,725 -63. ,098 1.00 36. ,06 D c

ATOM 16695 C ALA D 13 -27. ,491 2, .968 -60. ,938 1.00 36. 27 D c

ATOM 16696 O ALA D 13 -27. ,801 2, .454 -59. ,868 1.00 40. ,65 D 0

ATOM 16698 N SER D 14 -27. ,060 4, .217 -61. ,042 1.00 37. ,59 D N

ATOM 16699 CA SER D 14 -26. ,875 5 . ,084 -59. ,876 1.00 38. ,04 D c

ATOM 16701 CB SER D 14 -25. ,645 5 . .999 -60. ,083 1.00 42. ,14 D c

ATOM 16704 OG SER D 14 -24. ,562 5. ,260 -60. ,614 1.00 47. ,41 D 0

ATOM 16706 C SER D 14 -28. ,083 5 . .971 -59. ,583 1.00 38. ,35 D c

ATOM 16707 O SER D 14 -28. ,859 6 , ,313 -60. ,474 1.00 36. ,85 D 0

ATOM 16709 N VAL D 15 -28. ,182 6. ,416 -58. ,340 1.00 37. ,69 D N

ATOM 16710 CA VAL D 15 -29. ,196 7. ,398 -57. ,977 1.00 37. ,29 D C

ATOM 16712 CB VAL D 15 -29. 042 7. ,888 -56. ,535 1.00 32. ,29 D C

ATOM 16714 CGI VAL D 15 -30. ,064 8 , .977 -56. ,225 1.00 26. ,98 D c

ATOM 16718 CG2 VAL D 15 -29. ,190 6 , .719 - 55 . ,579 1.00 35. ,14 D c

ATOM 16722 C VAL D 15 -29. 094 8. .575 -58. .907 1.00 38. ,60 D c

ATOM 16723 O VAL D 15 -28. ,002 9 , ,118 -59. ,116 1.00 42. ,18 D 0

ATOM 16725 N GLY D 16 -30. 223 8 , .951 -59. ,494 1.00 40. ,11 D N

ATOM 16726 CA GLY D 16 -30. 285 10, .090 -60. ,411 1.00 38. ,90 D c

ATOM 16729 C GLY D 16 -30. 241 9. ,690 -61. ,866 1.00 37. ,21 D c

ATOM 16730 O GLY D 16 -30. 608 10. .474 -62, ,719 1.00 40. ,27 D 0

ATOM 16732 N ASP D 17 -29. ,784 8. ,479 -62, ,159 1.00 39. ,98 D N

ATOM 16733 CA ASP D 17 -29. ,714 7. .990 -63. ,537 1.00 40. ,64 D C

ATOM 16735 CB ASP D 17 -28. ,886 6. .710 -63. .615 1.00 46. ,54 D C

ATOM 16738 CG ASP D 17 -27. ,397 6 , .948 -63. .409 1.00 50. ,99 D C

ATOM 16739 ODl ASP D 17 -26. ,895 8 , .050 -63. .747 1.00 55 . ,50 D 0

ATOM 16740 OD2 ASP D 17 -26. ,724 6 , .002 -62. .937 1.00 46. ,59 D 0

ATOM 16741 C ASP D 17 -31. ,090 7, ,698 -64. ,146 1.00 44. ,06 D c

ATOM 16742 O ASP D 17 -32. ,088 7, .510 -63. ,428 1.00 43. ,56 D 0

ATOM 16744 N ARG D 18 -31. ,117 7, .635 -65. ,475 1.00 40. ,59 D N

ATOM 16745 CA ARG D 18 -32. ,311 7, .277 -66. ,202 1.00 39. ,07 D c

ATOM 16747 CB ARG D 18 -32. ,433 8 , ,071 -67. ,480 1.00 40. ,84 D c human fD_Fab

ATOM 16750 CG ARG D 18 -33. 500 7. ,518 -68. 398 1.00 41. 87 D C

ATOM 16753 CD ARG D 18 -33. 730 8. ,409 -69. 541 1.00 42. 69 D C

ATOM 16756 NE ARG D 18 -34. 020 9. ,763 -69. 115 1.00 41. 66 D N

ATOM 16758 CZ ARG D 18 -34. 224 10. ,759 -69. 960 1.00 42. ,99 D C

ATOM 16759 NHl ARG D 18 -34. ,174 10. ,539 -71.266 1.00 44. ,44 D N

ATOM 16762 NH2 ARG D 18 -34. 484 11.968 -69. 494 1.00 43. ,84 D N

ATOM 16765 C ARG D 18 -32. 284 5. ,808 -66. 554 1.00 41. 80 D C

ATOM 16766 O ARG D 18 -31.356 5. ,351 -67. 222 1.00 43. 13 D 0

ATOM 16768 N VAL D 19 -33. 339 5. ,096 -66. 148 1.00 41. ,89 D N

ATOM 16769 CA VAL D 19 -33. 504 3. ,671 -66. 420 1.00 37. ,52 D C

ATOM 16771 CB VAL D 19 -33. 984 2. ,960 -65. 168 1.00 32. 80 D C

ATOM 16773 CGI VAL D 19 -34. 429 1. 534 -65. 461 1.00 26. ,89 D C

ATOM 16777 CG2 VAL D 19 -32. 882 3. ,007 -64. 106 1.00 28. ,37 D C

ATOM 16781 C VAL D 19 -34. 505 3. ,486 -67. 541 1.00 37. ,40 D C

ATOM 16782 0 VAL D 19 -35. 558 4. ,120 -67. 542 1.00 43. ,15 D 0

ATOM 16784 N THR D 20 -34. 164 2. 625 -68. 496 1.00 37. ,47 D N

ATOM 16785 CA THR D 20 -34. 985 2. 385 -69. 665 1.00 36. ,22 D C

ATOM 16787 CB THR D 20 -34. 352 3. 032 -70. 925 1.00 39. 26 D C

ATOM 16789 OGl THR D 20 -34. 152 4. ,432 -70. 705 1.00 36. ,42 D 0

ATOM 16791 CG2 THR D 20 -35. 257 2. ,844 -72. 170 1.00 39. ,50 D C

ATOM 16795 C THR D 20 -35. 184 0. 879 -69. 875 1.00 37. ,81 D C

ATOM 16796 O THR D 20 -34. 229 0. ,142 -70. 084 1.00 38. ,10 D 0

ATOM 16798 N ILE D 21 -36. 447 0. ,457 -69. 839 1.00 36. ,44 D N

ATOM 16799 CA ILE D 21 -36. 858 -0. 935 -69. 951 1.00 35. ,58 D c

ATOM 16801 CB ILE D 21 -37. 529 -1. ,380 -68. 636 1.00 35. ,26 D c

ATOM 16803 CGI ILE D 21 -36. 546 -1. ,265 -67. 473 1.00 32. ,63 D c

ATOM 16806 CDl ILE D 21 -37. 226 -1. ,263 -66. 124 1.00 35. ,70 D c

ATOM 16810 CG2 ILE D 21 -38. 091 -2. 800 -68. 743 1.00 36. ,28 D c

ATOM 16814 C ILE D 21 -37. 861 -1. 049 -71. 105 1.00 32. ,56 D c

ATOM 16815 O ILE D 21 -38. 755 -0. ,221 -71. 236 1.00 31. ,36 D 0

ATOM 16817 N THR D 22 -37. 726 -2. ,078 -71. 928 1.00 32. ,64 D N

ATOM 16818 CA THR D 22 -38. 580 -2. 222 -73. 103 1.00 39. 99 D c

ATOM 16820 CB THR D 22 -37. 784 -2. ,031 -74. 465 1.00 40. 12 D c

ATOM 16822 OGl THR D 22 -36. 723 -2. ,981 -74. 568 1.00 41. ,12 D 0

ATOM 16824 CG2 THR D 22 -37. 208 -0. ,639 -74. 578 1.00 40. 07 D c

ATOM 16828 C THR D 22 -39. 345 -3. ,543 -73. 124 1.00 40. ,51 D c

ATOM 16829 O THR D 22 -38. 843 -4. 554 -72. 638 1.00 41. ,06 D 0

ATOM 16831 N CYS D 23 -40. 560 -3. ,499 -73. 687 1.00 43. ,14 D N

ATOM 16832 CA CYS D 23 -41. 371 -4. ,694 -73. ,996 1.00 42. ,54 D c

ATOM 16834 CB CYS D 23 -42. 593 -4. ,811 -73. 079 1.00 41. ,73 D c

ATOM 16837 SG CYS D 23 -42. 105 -5. ,668 -71.602 1.00 49. ,84 D S

ATOM 16839 C CYS D 23 -41. 822 -4. ,668 -75. 433 1.00 39. 03 D c

ATOM 16840 O CYS D 23 -42. 260 -3. ,645 -75. 921 1.00 38. ,84 D 0

ATOM 16842 N ILE D 24 -41. 702 -5. ,804 -76. 106 1.00 39. ,91 D N

ATOM 16843 CA ILE D 24 -42. 093 -5. ,919 -77. 500 1.00 42. ,16 D c

ATOM 16845 CB ILE D 24 -40. 862 -6. ,119 -78. ,414 1.00 41. ,46 D c

ATOM 16847 CGI ILE D 24 -39. 856 -4. ,983 -78. ,192 1.00 41. ,31 D c

ATOM 16850 CDl ILE D 24 -38. 471 -5. ,304 -78. ,647 1.00 43. ,89 D c

ATOM 16854 CG2 ILE D 24 -41. 293 -6. ,145 -79. ,873 1.00 41. ,33 D c

ATOM 16858 C ILE D 24 -43. 104 -7. ,063 -77. 622 1.00 43. ,17 D c

ATOM 16859 O ILE D 24 -42. 843 -8. 178 -77. ,187 1.00 41. ,39 D 0

ATOM 16861 N THR D 25 -44. 269 -6. ,755 -78. 187 1.00 44. ,58 D N

ATOM 16862 CA THR D 25 -45. 370 -7. ,716 -78. 297 1.00 40. ,51 D c

ATOM 16864 CB THR D 25 -46. 763 -7. ,039 -78. ,017 1.00 39. ,20 D c

ATOM 16866 OGl THR D 25 -46. 990 -5. ,950 -78. 928 1.00 35. ,42 D 0

ATOM 16868 CG2 THR D 25 -46. 837 -6. ,510 -76. ,579 1.00 34. ,65 D c

ATOM 16872 C THR D 25 -45. 353 -8. ,405 -79. 663 1.00 37, ,04 D c

ATOM 16873 O THR D 25 -44. 762 -7. ,903 -80. 616 1.00 35. ,11 D 0

ATOM 16875 N SER D 26 -45. 994 -9. ,567 -79. 734 1.00 41, ,69 D N

ATOM 16876 CA SER D 26 -46. 031 -10. ,392 -80. ,950 1.00 43. ,80 D C

ATOM 16878 CB SER D 26 -46. 441 -11. ,809 -80. ,579 1.00 39. ,47 D C

ATOM 16881 OG SER D 26 -47. 677 -11. ,771 -79. ,890 1.00 37. ,43 D 0

ATOM 16883 C SER D 26 -47. 018 -9. ,884 -81.987 1.00 46. ,46 D C

ATOM 16884 O SER D 26 -47. 036 -10. ,345 -83. ,120 1.00 48. ,60 D 0

ATOM 16886 N THR D 27 -47. 868 -8. ,960 -81. ,576 1.00 47, ,41 D N

ATOM 16887 CA THR D 27 -48. 888 -8. ,409 -82. ,441 1.00 45, ,05 D c

ATOM 16889 CB THR D 27 -50. 197 -9. ,187 -82. 336 1.00 44. ,82 D c

ATOM 16891 OGl THR D 27 -51. 134 -8. ,662 -83. ,285 1.00 44, ,14 D 0 human fD_Fab

ATOM 16893 CG2 THR D 27 -50. .786 -9. 102 -80. ,907 1.00 42. 26 D C

ATOM 16897 C THR D 27 -49. ,150 -6. 981 -82. ,049 1.00 44. 63 D C

ATOM 16898 O THR D 27 -48. ,829 -6. 568 -80. ,953 1.00 47. 84 D 0

ATOM 16900 N ASP D 28 -49. ,716 -6. 219 -82. ,969 1.00 47. 67 D N

ATOM 16901 CA ASP D 28 -50. ,107 -4. 848 -82. ,692 1.00 47. 49 D C

ATOM 16903 CB ASP D 28 -50.684 -4. 200 -83. ,952 1.00 44. 80 D C

ATOM 16906 CG ASP D 28 -51. ,179 -2. 801 -83. ,711 1.00 46. 92 D C

ATOM 16907 ODl ASP D 28 -50. ,358 -1. 873 -83. ,696 1.00 49. 51 D 0

ATOM 16908 OD2 ASP D 28 -52. ,401 -2. 618 -83. ,544 1.00 54. 29 D 0

ATOM 16909 C ASP D 28 -51. ,152 -4. 863 -81. ,570 1.00 46. 18 D C

ATOM 16910 O ASP D 28 -52. .211 -5. 494 -81. ,722 1.00 47. 34 D 0

ATOM 16912 N ILE D 29 -50. ,851 -4. 193 -80. ,454 1.00 41. 93 D N

ATOM 16913 CA ILE D 29 -51. ,779 -4. 145 -79. ,304 1.00 41. 67 D C

ATOM 16915 CB ILE D 29 -51.200 -4. 702 -77. ,969 1.00 34. 63 D C

ATOM 16917 CGI ILE D 29 -49. ,934 -3. 955 -77. ,543 1.00 38. 01 D c

ATOM 16920 CDl ILE D 29 -49. ,771 -3. 861 -76. ,024 1.00 37. 63 D c

ATOM 16924 CG2 ILE D 29 -51. ,007 -6. 186 -78. 053 1.00 27. 55 D c

ATOM 16928 C ILE D 29 -52. .296 -2. 736 -79. ,018 1.00 39. 51 D c

ATOM 16929 O ILE D 29 -52. ,732 -2. 447 -77. 902 1.00 39. 60 D 0

ATOM 16931 N ASP D 30 -52. ,239 -1. 861 -80. ,014 1.00 39. 32 D N

ATOM 16932 CA ASP D 30 -52. ,558 -0. 457 -79. ,822 1.00 41. 42 D c

ATOM 16934 CB ASP D 30 -54. ,078 -0. 246 -79. ,588 1.00 40. 38 D c

ATOM 16937 CG ASP D 30 -54. ,934 -0. 671 -80. .786 1.00 42. 75 D c

ATOM 16938 ODl ASP D 30 -54. ,669 -0. 174 -81. ,910 1.00 41. 44 D 0

ATOM 16939 OD2 ASP D 30 -55. .886 -1. 478 -80. ,594 1.00 41. 57 D 0

ATOM 16940 C ASP D 30 -51. ,728 0. 130 -78. ,675 1.00 40. 15 D c

ATOM 16941 O ASP D 30 -50. ,503 0. 135 -78. ,728 1.00 41.22 D 0

ATOM 16943 N ASP D 31 -52. ,400 0. 600 -77. ,634 1.00 43. 42 D N

ATOM 16944 CA ASP D 31 -51. ,728 1. 279 -76. ,527 1.00 41. 01 D c

ATOM 16946 CB ASP D 31 -52. ,088 2. 766 -76. ,468 1.00 45. 24 D c

ATOM 16949 CG ASP D 31 -53. ,571 3. 022 -76. ,352 1.00 49. 62 D c

ATOM 16950 ODl ASP D 31 -54. ,375 2. 061 -76. ,377 1.00 57. 10 D 0

ATOM 16951 OD2 ASP D 31 -53. ,928 4. 215 -76. ,248 1.00 48. 01 D 0

ATOM 16952 C ASP D 31 -51. ,988 0. 558 -75. ,207 1.00 36. 28 D c

ATOM 16953 O ASP D 31 -51. ,739 1. 101 -74. ,154 1.00 32. 60 D 0

ATOM 16955 N ASP D 32 -52. ,415 -0. 703 -75. ,283 1.00 34. 95 D N

ATOM 16956 CA ASP D 32 -52. ,873 -1. 451 -74. ,103 1.00 38. 03 D c

ATOM 16958 CB ASP D 32 -53. ,997 -2. 410 -74. ,493 1.00 38. 41 D c

ATOM 16961 CG ASP D 32 -55, ,248 -1. 675 -74. ,976 1.00 38. 53 D c

ATOM 16962 ODl ASP D 32 -55. ,770 -0. 830 -74. ,225 1.00 37. 63 D 0

ATOM 16963 OD2 ASP D 32 -55. ,703 -1. 932 -76. ,110 1.00 42. 67 D 0

ATOM 16964 C ASP D 32 -51. ,733 -2. 183 -73. ,408 1.00 36. 60 D c

ATOM 16965 O ASP D 32 -51. ,759 -3. 394 -73. ,234 1.00 34. 38 D 0

ATOM 16967 N MET D 33 -50. ,726 -1. 399 -73. ,026 1.00 34. 54 D N

ATOM 16968 CA MET D 33 -49. ,574 -1. 868 -72. ,279 1.00 33. 73 D c

ATOM 16970 CB MET D 33 -48. .299 -1. 398 -72. ,969 1.00 35. 54 D c

ATOM 16973 CG MET D 33 -47. ,024 -1. 894 -72. ,316 1.00 35. 05 D c

ATOM 16976 SD MET D 33 -47. ,103 -3. 637 -72. ,053 1.00 32. 83 D s

ATOM 16977 CE MET D 33 -46. ,752 -4. 307 -73. ,684 1.00 34. 79 D c

ATOM 16981 C MET D 33 -49. ,599 -1. 323 -70. ,858 1.00 35. 06 D c

ATOM 16982 O MET D 33 -49. ,919 -0. 163 -70. ,635 1.00 34. 55 D 0

ATOM 16984 N ASN D 34 -49. ,256 -2. 175 -69, ,900 1.00 37. 22 D N

ATOM 16985 CA ASN D 34 -49. ,210 -1. 791 -68. ,498 1.00 34. 26 D c

ATOM 16987 CB ASN D 34 -50. .226 -2. 594 -67, .675 1.00 30. 41 D c

ATOM 16990 CG ASN D 34 -51. ,609 -2. 559 -68. .246 1.00 26. 95 D c

ATOM 16991 ODl ASN D 34 -52. ,438 -1. 753 -67. .832 1.00 28. 43 D 0

ATOM 16992 ND2 ASN D 34 -51.876 -3. 440 -69. .204 1.00 25. ,17 D N

ATOM 16995 C ASN D 34 -47. ,832 -2. 061 -67. ,937 1.00 31. 22 D C

ATOM 16996 O ASN D 34 -47. ,124 -2. 937 -68. ,419 1.00 31.75 D 0

ATOM 16998 N TRP D 35 -47. ,479 -1. 330 -66. ,887 1.00 30. 31 D N

ATOM 16999 CA TRP D 35 -46. ,231 -1. 576 -66. ,166 1.00 30. 31 D C

ATOM 17001 CB TRP D 35 -45. ,226 -0. 434 -66, .400 1.00 27. 99 D C

ATOM 17004 CG TRP D 35 -44. .787 -0. 331 -67, .795 1.00 23. 87 D c

ATOM 17005 CDl TRP D 35 -45. ,316 0. 473 -68, .777 1.00 27. ,48 D c

ATOM 17007 NEl TRP D 35 -44. ,647 0. 275 -69, .957 1.00 28. 03 D N

ATOM 17009 CE2 TRP D 35 -43. ,670 -0. 667 -69. .752 1.00 25. 79 D c

ATOM 17010 CD2 TRP D 35 -43. ,739 -1. 072 -68. ,403 1.00 22. 90 D c

ATOM 17011 CE3 TRP D 35 -42. ,835 -2. 034 -67. ,934 1.00 26. 25 D c human fD_Fab

ATOM 17013 CZ3 TRP D 35 -41. ,935 -2. 550 -68. ,791 1.00 27. 80 D C

ATOM 17015 CH2 TRP D 35 -41. 881 -2. 126 -70. ,136 1.00 26. 87 D C

ATOM 17017 CZ2 TRP D 35 -42. ,745 -1. 191 -70. 628 1.00 26. 43 D C

ATOM 17019 C TRP D 35 -46. 490 -1. 735 -64. 688 1.00 29. 47 D C

ATOM 17020 O TRP D 35 -47. 255 -0. 972 -64. 116 1.00 27. 85 D 0

ATOM 17022 N TYR D 36 -45. 827 -2. 722 -64. 084 1.00 33. 75 D N

ATOM 17023 CA TYR D 36 -45. ,935 -3. 014 -62. ,663 1.00 32. ,31 D C

ATOM 17025 CB TYR D 36 -46. ,441 -4. 436 -62. ,437 1.00 32. .68 D c

ATOM 17028 CG TYR D 36 -47. ,883 -4. 710 -62. ,756 1.00 31. ,85 D c

ATOM 17029 CDl TYR D 36 -48. 869 -4. 561 -61. ,785 1.00 32. 56 D c

ATOM 17031 CEl TYR D 36 -50. 190 -4. 854 -62. 063 1.00 31.43 D c

ATOM 17033 CZ TYR D 36 -50. 537 -5. 325 -63. 317 1.00 31. 13 D c

ATOM 17034 OH TYR D 36 -51. 839 -5. 615 -63. 591 1.00 31. 78 D 0

ATOM 17036 CE2 TYR D 36 -49. 578 -5. 499 -64. 298 1.00 32. 62 D c

ATOM 17038 CD2 TYR D 36 -48. 257 -5. 199 -64. 010 1.00 33. 48 D c

ATOM 17040 C TYR D 36 -44. 582 -2. 942 -61. ,986 1.00 33. ,48 D c

ATOM 17041 O TYR D 36 -43. 559 -3. 209 -62. ,599 1.00 31. ,99 D 0

ATOM 17043 N GLN D 37 -44. 609 -2. 636 -60. ,692 1.00 33. ,21 D N

ATOM 17044 CA GLN D 37 -43. 426 -2. 663 -59. ,843 1.00 35. ,05 D c

ATOM 17046 CB GLN D 37 -43. 157 -1. 268 -59. 274 1.00 28. ,05 D c

ATOM 17049 CG GLN D 37 -41. 974 -1. 162 -58. 293 1.00 28. 49 D c

ATOM 17052 CD GLN D 37 -41. 958 0. 176 -57. 562 1.00 35. 08 D c

ATOM 17053 OEl GLN D 37 -41. 051 1. 025 -57. 748 1.00 35. 60 D 0

ATOM 17054 NE2 GLN D 37 -42. 982 0. 391 -56. 747 1.00 30. 68 D N

ATOM 17057 C GLN D 37 -43. 643 -3. 676 -58. ,718 1.00 36. ,19 D c

ATOM 17058 O GLN D 37 -44. 680 -3. 660 -58. ,065 1.00 35. ,65 D 0

ATOM 17060 N GLN D 38 -42. 666 -4. 551 -58. 494 1.00 38. ,65 D N

ATOM 17061 CA GLN D 38 -42. 695 -5. 429 -57. 333 1.00 40. ,45 D c

ATOM 17063 CB GLN D 38 -42. 903 -6. 871 -57. 738 1.00 40. ,55 D c

ATOM 17066 CG GLN D 38 -43. 346 -7. 719 -56. 574 1.00 36. ,60 D c

ATOM 17069 CD GLN D 38 -43. 530 -9. 124 -56. 960 1.00 38. ,22 D c

ATOM 17070 OEl GLN D 38 -42. 947 -9. 574 -57. 954 1.00 38. 62 D 0

ATOM 17071 NE2 GLN D 38 -44. 330 -9. 863 -56. 176 1.00 33. 38 D N

ATOM 17074 C GLN D 38 -41.437 -5. 360 -56. ,478 1.00 40. ,74 D c

ATOM 17075 O GLN D 38 -40. 358 -5. 761 -56. ,910 1.00 40. 11 D 0

ATOM 17077 N LYS D 39 -41. 611 -4. 902 -55. ,239 1.00 45. ,57 D N

ATOM 17078 CA LYS D 39 -40. 513 -4. 847 -54. ,277 1.00 49. 68 D c

ATOM 17080 CB LYS D 39 -40. 688 -3. 674 -53. 298 1.00 48. ,49 D c

ATOM 17083 CG LYS D 39 -40. 313 -2. 320 -53. 902 1.00 49. 06 D c

ATOM 17086 CD LYS D 39 -40. 700 -1. 111 -53. 036 1.00 50. 81 D c

ATOM 17089 CE LYS D 39 -40. 925 0. 153 -53. 901 1.00 51. 33 D c

ATOM 17092 NZ LYS D 39 -41. 271 1. 446 -53. 170 1.00 48. ,14 D N

ATOM 17096 C LYS D 39 -40. ,414 -6. 189 -53. ,551 1.00 55. ,21 D c

ATOM 17097 O LYS D 39 -41. ,406 -6. 931 -53. ,475 1.00 56. ,26 D 0

ATOM 17099 N PRO D 40 -39. ,211 -6. 522 -53. ,038 1.00 62. ,05 D N

ATOM 17100 CA PRO D 40 -38. 889 -7. 775 -52. ,360 1.00 62. ,70 D C

ATOM 17102 CB PRO D 40 -37. 899 -7. 320 -51. ,274 1.00 68. ,80 D C

ATOM 17105 CG PRO D 40 -37. 405 -5. 912 -51.724 1.00 68. 23 D c

ATOM 17108 CD PRO D 40 -38. 009 -5. 667 -53. ,075 1.00 66. ,28 D c

ATOM 17111 C PRO D 40 -40. 049 -8. 603 -51. ,754 1.00 64. 72 D c

ATOM 17112 0 PRO D 40 -40. 291 -9. 716 -52. ,216 1.00 67. ,84 D 0

ATOM 17113 N GLY D 41 -40. ,743 -8. ,099 -50. ,736 1.00 60. ,81 D N

ATOM 17114 CA GLY D 41 -41. ,824 -8. ,880 -50. ,104 1.00 61. ,13 D c

ATOM 17117 C GLY D 41 -43. 178 -8. ,202 -50. ,190 1.00 62. ,86 D c

ATOM 17118 0 GLY D 41 -43. 844 -8. ,018 -49. ,177 1.00 62. ,55 D 0

ATOM 17120 N LYS D 42 -43. 580 -7. 824 -51.405 1.00 59. ,84 D N

ATOM 17121 CA LYS D 42 -44. 774 -7. 003 -51. ,602 1.00 54. ,31 D c

ATOM 17123 CB LYS D 42 -44. 346 -5. 550 -51.857 1.00 59. ,34 D c

ATOM 17126 CG LYS D 42 -43. 352 -4. 965 -50. ,832 1.00 64. ,55 D c

ATOM 17129 CD LYS D 42 -44. 031 -4. 101 -49. ,771 1.00 68. ,76 D c

ATOM 17132 CE LYS D 42 -44. ,077 -2. ,621 -50. ,192 1.00 71. ,41 D c

ATOM 17135 NZ LYS D 42 -45. ,084 -1. ,787 -49. ,438 1.00 69. ,98 D N

ATOM 17139 C LYS D 42 -45. ,647 -7. ,499 -52. ,759 1.00 46. ,47 D c

ATOM 17140 0 LYS D 42 -45. ,206 -8. ,274 -53. ,607 1.00 43. ,15 D 0

ATOM 17142 N VAL D 43 -46. ,906 -7. ,070 -52. ,762 1.00 46. ,91 D N

ATOM 17143 CA VAL D 43 -47. 781 -7. ,313 -53. ,907 1.00 45. ,27 D c

ATOM 17145 CB VAL D 43 -49. 290 -7. ,118 -53. 587 1.00 42. ,88 D c

ATOM 17147 CGI VAL D 43 -49. 777 -8. 226 -52. 666 1.00 47. ,92 D c human fD_Fab

ATOM 17151 CG2 VAL D 43 -49. 566 -5. 763 -52.964 1.00 38. 10 D C

ATOM 17155 C VAL D 43 -47. 322 -6. 400 -55.055 1.00 40. 73 D C

ATOM 17156 O VAL D 43 -46. ,735 -5. 325 -54.826 1.00 36. ,31 D 0

ATOM 17158 N PRO D 44 -47. 506 -6. 857 -56.302 1.00 37. 70 D N

ATOM 17159 CA PRO D 44 -47. 237 -5. 917 -57.373 1.00 37. 73 D C

ATOM 17161 CB PRO D 44 -47. 387 -6. 767 -58.636 1.00 35. 99 D C

ATOM 17164 CG PRO D 44 -47. 226 -8. 170 -58.167 1.00 35. 89 D C

ATOM 17167 CD PRO D 44 -47. 856 -8. 187 -56.826 1.00 37. 78 D c

ATOM 17170 C PRO D 44 -48. 145 -4. 658 -57.350 1.00 33. 22 D c

ATOM 17171 O PRO D 44 -49. 252 -4. 671 -56.807 1.00 30. 46 D 0

ATOM 17172 N LYS D 45 -47. 577 -3. 586 -57.908 1.00 36. 13 D N

ATOM 17173 CA LYS D 45 -48. 092 -2. 245 -57.903 1.00 34. 90 D c

ATOM 17175 CB LYS D 45 -47. 117 -1. 387 -57.087 1.00 33. 30 D c

ATOM 17178 CG LYS D 45 -47. 384 0. 103 -57.071 1.00 34. 78 D c

ATOM 17181 CD LYS D 45 -48. 734 0. 424 -56.457 1.00 35. 10 D c

ATOM 17184 CE LYS D 45 -49. 129 1. 883 -56.720 1.00 36. 17 D c

ATOM 17187 NZ LYS D 45 -50. 562 2. 127 -56.397 1.00 33. 12 D N

ATOM 17191 C LYS D 45 -48. 148 -1. 778 -59.351 1.00 32. 75 D c

ATOM 17192 O LYS D 45 -47. 126 -1. 711 -60.021 1.00 31. 69 D 0

ATOM 17194 N LEU D 46 -49. 342 -1. 473 -59.831 1.00 33. 92 D N

ATOM 17195 CA LEU D 46 -49. 527 -0. 944 -61.167 1.00 31.60 D c

ATOM 17197 CB LEU D 46 -50. 995 -1. 056 -61.563 1.00 25. 10 D c

ATOM 17200 CG LEU D 46 -51. 328 -0. 684 -62.995 1.00 26. 28 D c

ATOM 17202 CDl LEU D 46 -50. 766 -1. 744 -63.983 1.00 19. 78 D c

ATOM 17206 CD2 LEU D 46 -52. 828 -0. 530 -63.083 1.00 20. 73 D c

ATOM 17210 C LEU D 46 -49. 080 0. 501 -61.201 1.00 34. 09 D c

ATOM 17211 O LEU D 46 -49. 657 1. 352 -60.495 1.00 34. 55 D 0

ATOM 17213 N LEU D 47 -48. 051 0. 770 -62.017 1.00 34. 89 D N

ATOM 17214 CA LEU D 47 -47. 491 2. 129 -62.185 1.00 34. 06 D C

ATOM 17216 CB LEU D 47 -45. 982 2. 056 -62.405 1.00 33. 90 D c

ATOM 17219 CG LEU D 47 -45. 112 1. 325 -61.375 1.00 31. 98 D C

ATOM 17221 CDl LEU D 47 -43. 731 1. 209 -61.924 1.00 30. 26 D c

ATOM 17225 CD2 LEU D 47 -45. 099 2. 023 -60.017 1.00 27. 87 D c

ATOM 17229 C LEU D 47 -48. 105 2. 882 -63.362 1.00 33. 92 D c

ATOM 17230 O LEU D 47 -48. 419 4. 055 -63.246 1.00 34. 67 D 0

ATOM 17232 N ILE D 48 -48. 264 2. 188 -64.486 1.00 33. 43 D N

ATOM 17233 CA ILE D 48 -48. 694 2. 778 -65.757 1.00 34. 40 D c

ATOM 17235 CB ILE D 48 -47. 514 2. 969 -66.751 1.00 31. 56 D c

ATOM 17237 CGI ILE D 48 -46. 427 3. 911 -66.179 1.00 31. ,94 D c

ATOM 17240 CDl ILE D 48 -46. 760 5. 404 -66.289 1.00 32. 59 D c

ATOM 17244 CG2 ILE D 48 -48. 027 3. 483 -68.086 1.00 27. 10 D c

ATOM 17248 C ILE D 48 -49. 716 1. 848 -66.418 1.00 36. 17 D c

ATOM 17249 O ILE D 48 -49. 492 0. 639 -66.489 1.00 29. 66 D 0

ATOM 17251 N SER D 49 -50. 841 2. 419 -66.864 1.00 37. 17 D N

ATOM 17252 CA SER D 49 -51.838 1. 663 -67.603 1.00 39. 71 D c

ATOM 17254 CB SER D 49 -53. 217 1. 703 -66.928 1.00 35. 81 D c

ATOM 17257 OG SER D 49 -53. 808 2. 994 -66.925 1.00 34. 88 D 0

ATOM 17259 C SER D 49 -51. 880 2. 173 -69.023 1.00 40. ,18 D c

ATOM 17260 O SER D 49 -51. 267 3. 182 -69.327 1.00 39. ,63 D 0

ATOM 17262 N GLY D 50 -52. 590 1. 444 -69.877 1.00 47. 29 D N

ATOM 17263 CA GLY D 50 -52. 633 1. 693 -71.297 1.00 50. 45 D c

ATOM 17266 C GLY D 50 -52. 791 3. 147 -71.633 1.00 56. ,73 D c

ATOM 17267 O GLY D 50 -53. 459 3. 888 -70.915 1.00 64. 25 D 0

ATOM 17269 N GLY D 51 -52. 168 3. 559 -72.728 1.00 57. 11 D N

ATOM 17270 CA GLY D 51 -52. 112 4. 974 -73.092 1.00 56. 80 D c

ATOM 17273 C GLY D 51 -50. 997 5. 690 -72.347 1.00 59. ,03 D c

ATOM 17274 O GLY D 51 -50. 876 6. 924 -72.424 1.00 60. ,10 D 0

ATOM 17276 N ASN D 52 -50. 183 4. 902 -71.634 1.00 54. ,22 D N

ATOM 17277 CA ASN D 52 -49. 074 5. 404 -70.833 1.00 50. ,11 D c

ATOM 17279 CB ASN D 52 -47. 993 5. 894 -71.772 1.00 49. ,44 D c

ATOM 17282 CG ASN D 52 -47. 510 4. 764 -72.684 1.00 51. ,75 D c

ATOM 17283 ODl ASN D 52 -47. 080 3. 710 -72.186 1.00 42. ,13 D 0

ATOM 17284 ND2 ASN D 52 -47. 634 4. ,947 -74.016 1.00 49. ,68 D N

ATOM 17287 C ASN D 52 -49. 545 6. 410 -69.792 1.00 44. 27 D c

ATOM 17288 O ASN D 52 -49. 001 7. 500 -69.617 1.00 39. ,54 D 0

ATOM 17290 N THR D 53 -50. 598 5. 986 -69.105 1.00 43. ,15 D N

ATOM 17291 CA THR D 53 -51. 260 6. 784 -68.097 1.00 43. ,77 D c

ATOM 17293 CB THR D 53 -52. 777 6. 495 -68.073 1.00 41. ,11 D c human fD_Fab

ATOM 17295 OGl THR D 53 -53.299 6. 630 -69.396 1.00 39. 66 D 0

ATOM 17297 CG2 THR D 53 -53.519 7. 442 -67.109 1.00 34. 90 D C

ATOM 17301 C THR D 53 -50.672 6. 450 -66.742 1.00 39. 58 D C

ATOM 17302 O THR D 53 -50.795 5. 328 -66.255 1.00 38. 47 D 0

ATOM 17304 N LEU D 54 -50.036 7. 443 -66.139 1.00 40. 49 D N

ATOM 17305 CA LEU D 54 -49.534 7. 325 -64.795 1.00 41. 11 D C

ATOM 17307 CB LEU D 54 -48.761 8. 584 -64.437 1.00 36. 74 D c

ATOM 17310 CG LEU D 54 -47.930 8. 611 -63.163 1.00 35. 52 D c

ATOM 17312 CDl LEU D 54 -46.904 7. 506 -63.167 1.00 31. 70 D c

ATOM 17316 CD2 LEU D 54 -47.269 9. 997 -63.050 1.00 36. 39 D c

ATOM 17320 C LEU D 54 -50.706 7. 126 -63.850 1.00 44. 45 D c

ATOM 17321 O LEU D 54 -51.739 7. 791 -63.981 1.00 45. 88 D 0

ATOM 17323 N ARG D 55 -50.545 6. 215 -62.898 1.00 45. 28 D N

ATOM 17324 CA ARG D 55 -51.611 5. 899 -61.951 1.00 43. 82 D c

ATOM 17326 CB ARG D 55 -51.563 4. 436 -61.518 1.00 38. 35 D c

ATOM 17329 CG ARG D 55 -51.536 3. 461 -62.675 1.00 36. 89 D c

ATOM 17332 CD ARG D 55 -52.819 3. 536 -63.488 1.00 35. 01 D c

ATOM 17335 NE ARG D 55 -53.909 2. 894 -62.769 1.00 32. 16 D N

ATOM 17337 cz ARG D 55 -55.043 2. 518 -63.332 1.00 30. 74 D c

ATOM 17338 NHl ARG D 55 -55.227 2. 742 -64.611 1.00 30. 81 D N

ATOM 17341 NH2 ARG D 55 -55.987 1. 916 -62.613 1.00 29. 27 D N

ATOM 17344 c ARG D 55 -51.531 6. 778 -60.729 1.00 46. 70 D c

ATOM 17345 0 ARG D 55 -50.476 7. 326 -60.431 1.00 47. 48 D 0

ATOM 17347 N PRO D 56 -52.672 6. 958 -60.046 1.00 51. 21 D N

ATOM 17348 CA PRO D 56 -52.758 7. 650 -58.764 1.00 50. 30 D C

ATOM 17350 CB PRO D 56 -54.130 7. 221 -58.255 1.00 53. 21 D c

ATOM 17353 CG PRO D 56 -54.944 7. 156 -59.506 1.00 52. 73 D c

ATOM 17356 CD PRO D 56 -54.011 6. 547 -60.523 1.00 49. 72 D c

ATOM 17359 C PRO D 56 -51.649 7. 313 -57.761 1.00 51.06 D c

ATOM 17360 O PRO D 56 -51.457 6. 150 -57.403 1.00 49. 12 D 0

ATOM 17361 N GLY D 57 -50.915 8. 350 -57.350 1.00 51. 01 D N

ATOM 17362 CA GLY D 57 -49.930 8. 250 -56.279 1.00 49. 74 D c

ATOM 17365 C GLY D 57 -48.654 7. 557 -56.691 1.00 48. 20 D c

ATOM 17366 O GLY D 57 -47.962 6. 954 -55.852 1.00 50. 72 D 0

ATOM 17368 N VAL D 58 -48.359 7. 621 -57.985 1.00 44. 93 D N

ATOM 17369 CA VAL D 58 -47.138 7. 053 -58.524 1.00 45. 49 D c

ATOM 17371 CB VAL D 58 -47.456 6. 088 -59.729 1.00 42. 99 D c

ATOM 17373 CGI VAL D 58 -46.186 5. 499 -60.332 1.00 40. 31 D c

ATOM 17377 CG2 VAL D 58 -48.396 4. 937 -59.281 1.00 39. 31 D c

ATOM 17381 C VAL D 58 -46.296 8. 274 -58.906 1.00 43. 15 D c

ATOM 17382 O VAL D 58 -46.792 9. 155 -59.598 1.00 47. 44 D 0

ATOM 17384 N PRO D 59 -45.045 8. 359 -58.423 1.00 42. 17 D N

ATOM 17385 CA PRO D 59 -44.238 9. 532 -58.770 1.00 44. 09 D c

ATOM 17387 CB PRO D 59 -42.874 9. 232 -58.143 1.00 38. 38 D c

ATOM 17390 CG PRO D 59 -43.130 8. 245 -57.085 1.00 39. 16 D c

ATOM 17393 CD PRO D 59 -44.309 7. 429 -57.547 1.00 42. 40 D c

ATOM 17396 C PRO D 59 -44.117 9. 758 -60.284 1.00 47. 18 D c

ATOM 17397 O PRO D 59 -44.098 8. 804 -61.072 1.00 46. 90 D 0

ATOM 17398 N SER D 60 -44.050 11.030 -60.667 1.00 49. 68 D N

ATOM 17399 CA SER D 60 -43.988 11. 441 -62.066 1.00 46. 46 D c

ATOM 17401 CB SER D 60 -44.247 12. 938 -62.154 1.00 43. 76 D c

ATOM 17404 OG SER D 60 -43.384 13. 605 -61.248 1.00 50. 04 D 0

ATOM 17406 C SER D 60 -42.653 11. 096 -62.739 1.00 44. 56 D c

ATOM 17407 0 SER D 60 -42.542 11. 207 -63.956 1.00 40. 72 D 0

ATOM 17409 N ARG D 61 -41.652 10. 680 -61.953 1.00 44. 17 D N

ATOM 17410 CA ARG D 61 -40.384 10.166 -62.499 1.00 40. 43 D c

ATOM 17412 CB ARG D 61 -39.329 9. 997 -61.387 1.00 38. ,02 D c

ATOM 17415 CG ARG D 61 -39.632 8. 969 -60.306 1.00 39. 70 D c

ATOM 17418 CD ARG D 61 -38.426 8. 708 -59.378 1.00 39. 65 D c

ATOM 17421 NE ARG D 61 -38.745 7. 742 -58.320 1.00 38. 21 D N

ATOM 17423 CZ ARG D 61 -39.349 8. 062 -57.171 1.00 41. 51 D c

ATOM 17424 NHl ARG D 61 -39.727 9. 315 -56.917 1.00 44. 27 D N

ATOM 17427 NH2 ARG D 61 -39.606 7. 127 -56.262 1.00 38. 54 D N

ATOM 17430 C ARG D 61 -40.587 8. ,872 -63.326 1.00 39. ,80 D C

ATOM 17431 0 ARG D 61 -39.771 8. 541 -64.184 1.00 37. 69 D 0

ATOM 17433 N PHE D 62 -41.695 8. 170 -63.075 1.00 39. 86 D N

ATOM 17434 CA PHE D 62 -42.136 7. 057 -63.903 1.00 35. 79 D C

ATOM 17436 CB PHE D 62 -42.968 6. 089 -63.075 1.00 28. 77 D c human fD_Fab

ATOM 17439 CG PHE D 62 -42. 208 5. 447 -61. 962 1.00 27. ,76 D C

ATOM 17440 CDl PHE D 62 -41. 388 4. 349 -62. 210 1.00 26. ,83 D C

ATOM 17442 CEl PHE D 62 -40. ,655 3. 767 -61. 180 1.00 25. ,90 D C

ATOM 17444 CZ PHE D 62 -40. ,748 4. 265 -59. ,904 1.00 24. ,27 D C

ATOM 17446 CE2 PHE D 62 -41. ,568 5. 343 -59. 640 1.00 26. ,74 D C

ATOM 17448 CD2 PHE D 62 -42. ,288 5. 940 -60. 666 1.00 26. ,76 D C

ATOM 17450 C PHE D 62 -42. ,977 7. 542 -65. 090 1.00 38. ,99 D C

ATOM 17451 O PHE D 62 -43. ,862 8. 384 -64. 935 1.00 40. ,31 D 0

ATOM 17453 N SER D 63 -42. 686 7. 007 -66. 273 1.00 39. ,17 D N

ATOM 17454 CA SER D 63 -43. 438 7. 317 -67. 474 1.00 36. ,38 D C

ATOM 17456 CB SER D 63 -42. 955 8. 630 -68. 093 1.00 36. 88 D c

ATOM 17459 OG SER D 63 -41. ,639 8. 510 -68. 580 1.00 40. ,53 D 0

ATOM 17461 C SER D 63 -43. ,348 6. 199 -68. 498 1.00 35. ,84 D c

ATOM 17462 O SER D 63 -42. 360 5. 502 -68. 584 1.00 35. ,92 D 0

ATOM 17464 N GLY D 64 -44. 401 6. 040 -69. 283 1.00 38. ,54 D N

ATOM 17465 CA GLY D 64 -44. 443 5. 041 -70. 344 1.00 36. ,67 D c

ATOM 17468 C GLY D 64 -44. 557 5. 685 -71. 714 1.00 38. ,04 D c

ATOM 17469 O GLY D 64 -44. 996 6. 821 -71. 849 1.00 38. ,33 D 0

ATOM 17471 N SER D 65 -44. 150 4. 943 -72. 732 1.00 38. ,46 D N

ATOM 17472 CA SER D 65 -44. 244 5. 401 -74. 104 1.00 38. 82 D c

ATOM 17474 CB SER D 65 -43. ,104 6. 372 -74. 438 1.00 40. ,82 D c

ATOM 17477 OG SER D 65 -41. ,835 5. 803 -74. 180 1.00 45. ,84 D 0

ATOM 17479 C SER D 65 -44. ,263 4. 207 -75. 057 1.00 41. ,29 D c

ATOM 17480 O SER D 65 -43. 881 3. 091 -74. 688 1.00 37. .98 D 0

ATOM 17482 N GLY D 66 -44. 717 4. 462 -76. 278 1.00 43. ,31 D N

ATOM 17483 CA GLY D 66 -44. 832 3. 435 -77. 289 1.00 41. ,05 D c

ATOM 17486 C GLY D 66 -46. 264 3. 125 -77. 632 1.00 41.45 D c

ATOM 17487 O GLY D 66 -47. 178 3. 485 -76. 915 1.00 42. 06 D 0

ATOM 17489 N SER D 67 -46. 446 2. 456 -78. 757 1.00 42. ,39 D N

ATOM 17490 CA SER D 67 -47. ,760 2. 131 -79. 270 1.00 42. ,75 D c

ATOM 17492 CB SER D 67 -48. ,488 3. 376 -79. 766 1.00 43. ,07 D c

ATOM 17495 OG SER D 67 -49. 648 2. 999 -80. 473 1.00 45. ,00 D 0

ATOM 17497 C SER D 67 -47. 571 1. 157 -80. 408 1.00 43. ,19 D c

ATOM 17498 O SER D 67 -46. 577 1. 224 -81. 124 1.00 48. ,13 D 0

ATOM 17500 N GLY D 68 -48. 519 0. 241 -80. 556 1.00 44. ,00 D N

ATOM 17501 CA GLY D 68 -48. 408 -0. 842 -81. 519 1.00 41. ,75 D c

ATOM 17504 C GLY D 68 -47. 724 -2. 055 -80. 913 1.00 44. ,43 D c

ATOM 17505 O GLY D 68 -48. 373 -2. 868 -80. 259 1.00 42. ,18 D 0

ATOM 17507 N THR D 69 -46. ,409 -2. ,165 -81. 105 1.00 43. ,95 D N

ATOM 17508 CA THR D 69 -45. ,671 -3. 358 -80. 674 1.00 40. ,40 D c

ATOM 17510 CB THR D 69 -45. 160 -4. 222 -81.859 1.00 41. ,35 D c

ATOM 17512 OGl THR D 69 -44. 059 -3. 580 -82. 504 1.00 42. ,22 D 0

ATOM 17514 CG2 THR D 69 -46. 267 -4. 495 -82. 882 1.00 42. ,62 D c

ATOM 17518 C THR D 69 -44. 506 -3. 078 -79. 720 1.00 36. ,97 D c

ATOM 17519 O THR D 69 -44. 123 -3. 974 -78. 980 1.00 38. ,90 D 0

ATOM 17521 N ASP D 70 -44. 004 -1. 838 -79. 694 1.00 35. ,57 D N

ATOM 17522 CA ASP D 70 -42. ,734 -1. ,474 -79. 052 1.00 37. ,06 D c

ATOM 17524 CB ASP D 70 -41. 826 -0. ,755 -80. ,068 1.00 38. .45 D c

ATOM 17527 CG ASP D 70 -41. 124 -1. ,705 -81. ,060 1.00 43. .59 D c

ATOM 17528 ODl ASP D 70 -41.464 -2. 912 -81. ,207 1.00 40. .00 D 0

ATOM 17529 OD2 ASP D 70 -40. 185 -1. 201 -81. ,713 1.00 48. ,32 D 0

ATOM 17530 C ASP D 70 -42. 964 -0. ,511 -77. 878 1.00 36. ,49 D c

ATOM 17531 O ASP D 70 -43. 244 0. ,654 -78. 097 1.00 37. ,09 D 0

ATOM 17533 N PHE D 71 -42. 787 -0. ,981 -76. 641 1.00 38. ,41 D N

ATOM 17534 CA PHE D 71 -43. 106 -0. ,183 -75. 446 1.00 35. ,81 D c

ATOM 17536 CB PHE D 71 -44. ,277 -0. ,818 -74. ,677 1.00 30, .00 D c

ATOM 17539 CG PHE D 71 -45. ,506 -0. ,954 -75. ,503 1.00 25. .69 D c

ATOM 17540 CDl PHE D 71 -46. ,491 -0. ,001 -75. 456 1.00 23. .97 D c

ATOM 17542 CEl PHE D 71 -47. 602 -0. 103 -76. 240 1.00 24. .56 D c

ATOM 17544 CZ PHE D 71 -47. ,734 -1. ,151 -77. 101 1.00 23. .65 D c

ATOM 17546 CE2 PHE D 71 -46. ,767 -2. ,098 -77. 169 1.00 23. .88 D c

ATOM 17548 CD2 PHE D 71 -45. 641 -2. ,002 -76. 384 1.00 27. ,39 D c

ATOM 17550 C PHE D 71 -41.928 0. ,013 -74. ,513 1.00 35. ,56 D c

ATOM 17551 O PHE D 71 -41. 070 -0. ,861 -74. 377 1.00 37. .95 D 0

ATOM 17553 N THR D 72 -41. ,903 1. ,174 -73. ,873 1.00 33, .23 D N

ATOM 17554 CA THR D 72 -40. ,794 1. ,571 -73. ,021 1.00 37, .46 D c

ATOM 17556 CB THR D 72 -39. ,918 2. ,640 -73. ,741 1.00 34, .53 D c

ATOM 17558 OGl THR D 72 -39. ,376 2. ,072 -74. ,941 1.00 37, .40 D 0 human fD_Fab

ATOM 17560 CG2 THR D 72 -38. 785 3. 119 -72. 865 1.00 27. ,41 D C

ATOM 17564 C THR D 72 -41. ,271 2. 146 -71. 688 1.00 36. ,64 D C

ATOM 17565 O THR D 72 -42. ,141 3. 018 -71. 665 1.00 37. ,03 D 0

ATOM 17567 N LEU D 73 -40. 681 1. 653 -70. 597 1.00 33. ,05 D N

ATOM 17568 CA LEU D 73 -40. 833 2. 256 -69. 269 1.00 34. ,80 D c

ATOM 17570 CB LEU D 73 -41. ,049 1. 180 -68. 194 1.00 30. ,43 D c

ATOM 17573 CG LEU D 73 -40. 999 1. 635 -66. 732 1.00 30. ,48 D c

ATOM 17575 CDl LEU D 73 -42. 244 2. 474 -66. 347 1.00 28. ,28 D c

ATOM 17579 CD2 LEU D 73 -40. 783 0. 466 -65. 780 1.00 21. ,69 D c

ATOM 17583 C LEU D 73 -39. 557 3. 028 -68. 941 1.00 39. ,42 D c

ATOM 17584 O LEU D 73 -38. 456 2. 469 -69. 035 1.00 41. ,38 D 0

ATOM 17586 N THR D 74 -39. 710 4. 284 -68. 523 1.00 36. ,43 D N

ATOM 17587 CA THR D 74 -38. 579 5. 137 -68. 172 1.00 35. ,96 D c

ATOM 17589 CB THR D 74 -38. ,465 6. 375 -69. ,114 1.00 35. ,05 D c

ATOM 17591 OGl THR D 74 -38. ,371 5. 952 -70. 494 1.00 32. ,33 D 0

ATOM 17593 CG2 THR D 74 -37. 261 7. 219 -68. 744 1.00 26. ,80 D c

ATOM 17597 C THR D 74 -38. 728 5. 622 -66. 736 1.00 39. ,64 D c

ATOM 17598 O THR D 74 -39. 755 6. 205 -66. 393 1.00 36. ,35 D 0

ATOM 17600 N ILE D 75 -37. 707 5. 364 -65. 909 1.00 38. ,18 D N

ATOM 17601 CA ILE D 75 -37. 559 6. 021 -64. 609 1.00 38. ,32 D c

ATOM 17603 CB ILE D 75 -37. 103 5. 037 -63. 505 1.00 37. ,96 D c

ATOM 17605 CGI ILE D 75 -37. ,964 3. 764 -63. 519 1.00 35. .94 D c

ATOM 17608 CDl ILE D 75 -37. ,345 2. 571 -62. 825 1.00 35. ,28 D c

ATOM 17612 CG2 ILE D 75 -37. 150 5. 720 -62. 126 1.00 36. ,47 D c

ATOM 17616 C ILE D 75 -36. ,524 7. 133 -64. 796 1.00 39. ,92 D c

ATOM 17617 O ILE D 75 -35. 360 6. 853 -65. 023 1.00 40. ,12 D 0

ATOM 17619 N SER D 76 -36. 952 8. 389 -64. 719 1.00 43. 39 D N

ATOM 17620 CA SER D 76 -36. 146 9. 522 -65. 198 1.00 45. ,47 D C

ATOM 17622 CB SER D 76 -37. 017 10. 766 -65. 415 1.00 44. ,14 D c

ATOM 17625 OG SER D 76 -37. ,332 11. 406 -64. ,173 1.00 46. ,89 D 0

ATOM 17627 C SER D 76 -35. ,006 9. 880 -64. ,263 1.00 48. ,55 D c

ATOM 17628 O SER D 76 -33. ,958 10. 380 -64. 700 1.00 53. ,87 D 0

ATOM 17630 N SER D 77 -35. ,220 9. 651 -62. 978 1.00 45. ,31 D N

ATOM 17631 CA SER D 77 -34. 213 9. 981 -61. 986 1.00 44. ,77 D c

ATOM 17633 CB SER D 77 -34. 418 11. 423 -61. 500 1.00 45. ,28 D c

ATOM 17636 OG SER D 77 -33. 721 11. 656 -60. 291 1.00 53. ,02 D 0

ATOM 17638 C SER D 77 -34. 289 8. 948 -60. 856 1.00 43. ,15 D c

ATOM 17639 O SER D 77 -34. ,973 9. ,157 -59. ,859 1.00 46. ,57 D 0

ATOM 17641 N LEU D 78 -33. ,571 7. ,845 -61. ,044 1.00 36. ,02 D N

ATOM 17642 CA LEU D 78 -33. 629 6. ,693 -60. ,164 1.00 37. ,92 D c

ATOM 17644 CB LEU D 78 -32. 617 5. 643 -60. 635 1.00 36. ,50 D c

ATOM 17647 CG LEU D 78 -32. 696 4. 278 -59. ,969 1.00 38. ,22 D c

ATOM 17649 CDl LEU D 78 -34. 033 3. 613 -60. 305 1.00 39. ,21 D c

ATOM 17653 CD2 LEU D 78 -31. 508 3. 413 -60. 386 1.00 38. ,71 D c

ATOM 17657 C LEU D 78 -33. 386 7. 016 -58. 688 1.00 35. ,46 D c

ATOM 17658 O LEU D 78 -32. ,422 7. ,680 -58. ,334 1.00 37, .47 D 0

ATOM 17660 N GLN D 79 -34. 283 6. ,537 -57. ,831 1.00 38, .02 D N

ATOM 17661 CA GLN D 79 -34. ,200 6. 765 -56. ,391 1.00 39, .42 D c

ATOM 17663 CB GLN D 79 -35. ,502 7. ,401 -55. 855 1.00 35. .52 D c

ATOM 17666 CG GLN D 79 -35. ,782 8. 814 -56. ,314 1.00 31. .66 D c

ATOM 17669 CD GLN D 79 -34. 670 9. 778 -55. 963 1.00 36. .40 D c

ATOM 17670 OEl GLN D 79 -34. 027 10. ,372 -56. ,853 1.00 41. .81 D 0

ATOM 17671 NE2 GLN D 79 -34. 408 9. ,923 -54. ,670 1.00 38. ,07 D N

ATOM 17674 C GLN D 79 -33. ,965 5. ,458 -55. ,674 1.00 37, ,58 D C

ATOM 17675 O GLN D 79 -34. ,302 4. ,417 -56. ,201 1.00 38, .75 D 0

ATOM 17677 N PRO D 80 -33. ,387 5. 503 -54. ,457 1.00 40, .59 D N

ATOM 17678 CA PRO D 80 -33. ,161 4. 259 -53. 695 1.00 41.83 D c

ATOM 17680 CB PRO D 80 -32. ,679 4. ,767 -52. ,332 1.00 40, .95 D c

ATOM 17683 CG PRO D 80 -32. ,063 6. ,098 -52. ,644 1.00 40, ,25 D c

ATOM 17686 CD PRO D 80 -32. ,895 6. ,688 -53. ,721 1.00 38, .34 D c

ATOM 17689 C PRO D 80 -34. 401 3. ,360 -53. ,531 1.00 41, .58 D c

ATOM 17690 O PRO D 80 -34. ,303 2. ,137 -53. ,690 1.00 40, .30 D 0

ATOM 17691 N GLU D 81 -35. ,551 3. ,957 -53. ,235 1.00 40, .96 D N

ATOM 17692 CA GLU D 81 -36. ,799 3. ,192 -53. ,083 1.00 41, .06 D c

ATOM 17694 CB GLU D 81 -37. ,913 4. ,070 -52. ,493 1.00 42, .37 D c

ATOM 17697 CG GLU D 81 -38. ,345 5. ,257 -53. ,347 1.00 43, .97 D c

ATOM 17700 CD GLU D 81 -37. ,804 6. ,588 -52. ,833 1.00 52, .48 D c

ATOM 17701 OEl GLU D 81 -36. ,571 6. ,707 -52. ,607 1.00 50, .07 D 0 human fD_Fab

ATOM 17702 OE2 GLU D 81 -38. 628 7. ,519 -52. 653 1.00 57. ,71 D 0

ATOM 17703 C GLU D 81 -37. 315 2. ,504 -54. 367 1.00 40. 11 D C

ATOM 17704 O GLU D 81 -38. 235 1. ,691 -54. 297 1.00 39. 57 D 0

ATOM 17706 N ASP D 82 -36. 714 2. 812 -55. 513 1.00 40. 13 D N

ATOM 17707 CA ASP D 82 -37. 126 2. ,264 -56. ,799 1.00 40. ,22 D C

ATOM 17709 CB ASP D 82 -36. 738 3. 234 -57. 933 1.00 40. ,59 D C

ATOM 17712 CG ASP D 82 -37. 456 4. 560 -57. 832 1.00 36. ,67 D c

ATOM 17713 ODl ASP D 82 -38. 498 4. 622 -57. 144 1.00 39. ,80 D 0

ATOM 17714 OD2 ASP D 82 -36. 992 5. 529 -58. 440 1.00 32. 08 D 0

ATOM 17715 C ASP D 82 -36. 538 0. 903 -57. 094 1.00 41. 61 D c

ATOM 17716 O ASP D 82 -36. 848 0. 323 -58. 146 1.00 44. 42 D 0

ATOM 17718 N VAL D 83 -35. 687 0. 399 -56. 197 1.00 38. 81 D N

ATOM 17719 CA VAL D 83 -35. 130 -0. ,944 -56. 344 1.00 38. 29 D c

ATOM 17721 CB VAL D 83 -33. 970 -1. 218 -55. 325 1.00 37. ,45 D c

ATOM 17723 CGI VAL D 83 -34. 451 -1. ,158 -53. 905 1.00 41. 14 D c

ATOM 17727 CG2 VAL D 83 -33. 340 -2. 563 -55. 577 1.00 40. 26 D c

ATOM 17731 C VAL D 83 -36. 278 -1. ,970 -56. 213 1.00 41. 19 D c

ATOM 17732 O VAL D 83 -37. 025 -1. 983 -55. 239 1.00 43. 73 D 0

ATOM 17734 N ALA D 84 -36. 421 -2. 813 -57. 230 1.00 38. 64 D N

ATOM 17735 CA ALA D 84 -37. 630 -3. 613 -57. 422 1.00 35. 15 D c

ATOM 17737 CB ALA D 84 -38. 859 -2. ,653 -57. 648 1.00 28. 02 D c

ATOM 17741 C ALA D 84 -37. 417 -4. ,471 -58. ,649 1.00 35. 36 D c

ATOM 17742 O ALA D 84 -36. 434 -4. ,268 -59. 357 1.00 32. 60 D 0

ATOM 17744 N THR D 85 -38. 314 -5. ,431 -58. 907 1.00 34. 15 D N

ATOM 17745 CA THR D 85 -38. 426 -6. ,035 -60. 247 1.00 33. 32 D c

ATOM 17747 CB THR D 85 -38. 403 -7. 572 -60. 208 1.00 36. 97 D c

ATOM 17749 OGl THR D 85 -37. 199 -8. 031 -59. 557 1.00 32. 91 D 0

ATOM 17751 CG2 THR D 85 -38. 463 -8. 165 -61. 617 1.00 30. 74 D c

ATOM 17755 C THR D 85 -39. 682 -5. 453 -60. 950 1.00 35. 11 D c

ATOM 17756 O THR D 85 -40. 745 -5. ,311 -60. 353 1.00 36. ,71 D 0

ATOM 17758 N TYR D 86 -39. 510 -5. 060 -62. 208 1.00 38. ,15 D N

ATOM 17759 CA TYR D 86 -40. 526 -4. ,370 -62. 989 1.00 35. 18 D c

ATOM 17761 CB TYR D 86 -39. 919 -3. ,105 -63. 609 1.00 32. 82 D c

ATOM 17764 CG TYR D 86 -39. 692 -2. ,030 -62. 579 1.00 32. 79 D c

ATOM 17765 CDl TYR D 86 -40. 714 -1. 165 -62. 215 1.00 33. 11 D c

ATOM 17767 CEl TYR D 86 -40. 503 -0. 195 -61. 263 1.00 33. 29 D c

ATOM 17769 CZ TYR D 86 -39. 276 -0. 105 -60. 652 1.00 29. 81 D c

ATOM 17770 OH TYR D 86 -39. 062 0. ,846 -59. ,693 1.00 31. ,53 D 0

ATOM 17772 CE2 TYR D 86 -38. 271 -0. ,960 -60. ,987 1.00 26. ,87 D c

ATOM 17774 CD2 TYR D 86 -38. 474 -1. ,908 -61. ,936 1.00 29. ,53 D c

ATOM 17776 C TYR D 86 -41. 036 -5. 288 -64. ,078 1.00 34. 53 D c

ATOM 17777 O TYR D 86 -40. 257 -6. 027 -64. ,682 1.00 32. 46 D 0

ATOM 17779 N TYR D 87 -42. 339 -5. 253 -64. 310 1.00 33. 76 D N

ATOM 17780 CA TYR D 87 -43. 017 -6. ,174 -65. 244 1.00 31. 51 D c

ATOM 17782 CB TYR D 87 -43. 875 -7. ,181 -64. 475 1.00 27. 78 D c

ATOM 17785 CG TYR D 87 -43. 073 -8. 116 -63. 593 1.00 30. 93 D c

ATOM 17786 CDl TYR D 87 -42. 448 -9. ,219 -64. ,130 1.00 25. ,34 D c

ATOM 17788 CEl TYR D 87 -41. 732 -10. ,075 -63. ,359 1.00 26. ,90 D c

ATOM 17790 CZ TYR D 87 -41. 620 -9. ,857 -62. ,021 1.00 28. 52 D c

ATOM 17791 OH TYR D 87 -40. 878 -10. ,744 -61. 273 1.00 30. 59 D 0

ATOM 17793 CE2 TYR D 87 -42. 232 -8. ,773 -61. ,434 1.00 28. 56 D c

ATOM 17795 CD2 TYR D 87 -42. 955 -7. ,898 -62. 222 1.00 31. 15 D c

ATOM 17797 C TYR D 87 -43. 942 -5. ,398 -66. ,148 1.00 31. 19 D c

ATOM 17798 O TYR D 87 -44. 720 -4. ,579 -65. 665 1.00 33. 53 D 0

ATOM 17800 N CYS D 88 -43. 855 -5. ,645 -67. ,449 1.00 30. ,54 D N

ATOM 17801 CA CYS D 88 -44. 883 -5. ,163 -68. ,363 1.00 30. ,46 D c

ATOM 17803 CB CYS D 88 -44. 325 -4. 886 -69. ,755 1.00 28. ,22 D c

ATOM 17806 SG CYS D 88 -43. 797 -6. ,342 -70. ,731 1.00 31. ,02 D S

ATOM 17808 C CYS D 88 -46. 022 -6. ,193 -68. 426 1.00 32. ,46 D c

ATOM 17809 0 CYS D 88 -45. 843 -7. ,373 -68. ,118 1.00 31. 88 D 0

ATOM 17811 N LEU D 89 -47. 205 -5. ,715 -68. ,784 1.00 33. 52 D N

ATOM 17812 CA LEU D 89 -48. 341 -6. ,583 -69. ,029 1.00 33. ,01 D c

ATOM 17814 CB LEU D 89 -49. 236 -6. ,736 -67. ,782 1.00 30. ,63 D c

ATOM 17817 CG LEU D 89 -50. 594 -7. ,460 -67. ,971 1.00 27. ,69 D c

ATOM 17819 CDl LEU D 89 -50. 563 -8. .889 -67. ,528 1.00 20. ,55 D c

ATOM 17823 CD2 LEU D 89 -51. 700 -6. ,729 -67. 232 1.00 25. ,06 D c

ATOM 17827 C LEU D 89 -49. 139 -6. ,000 -70. ,168 1.00 32. ,58 D c

ATOM 17828 0 LEU D 89 -49. 558 -4. ,857 -70. ,096 1.00 29. ,29 D 0 human fD_Fab

ATOM 17830 N GLN D 90 -49. ,354 -6. 819 -71. 194 1.00 31. ,94 D N

ATOM 17831 CA GLN D 90 -50. 220 -6. 480 -72. 311 1.00 36. ,73 D C

ATOM 17833 CB GLN D 90 -49. 793 -7. ,176 -73. 616 1.00 31. ,28 D C

ATOM 17836 CG GLN D 90 -50. ,019 -8. ,669 -73. 703 1.00 29. 06 D C

ATOM 17839 CD GLN D 90 -51.428 -9. 090 -74. 095 1.00 24. 98 D c

ATOM 17840 OEl GLN D 90 -52. ,190 -8. ,334 -74. 702 1.00 26. ,11 D 0

ATOM 17841 NE2 GLN D 90 -51. ,774 -10. 317 -73. 745 1.00 21. 58 D N

ATOM 17844 C GLN D 90 -51. ,654 -6. 834 -71. 950 1.00 38. ,76 D c

ATOM 17845 O GLN D 90 -51.932 -7. 922 -71.446 1.00 33. ,01 D 0

ATOM 17847 N SER D 91 -52. ,561 -5. 896 -72. 204 1.00 41. ,17 D N

ATOM 17848 CA SER D 91 -53. ,978 -6. ,118 -71. 958 1.00 38. ,70 D c

ATOM 17850 CB SER D 91 -54. ,413 -5. ,404 -70. 672 1.00 32. ,95 D C

ATOM 17853 OG SER D 91 -54. ,149 -4. ,033 -70. 731 1.00 28. ,88 D 0

ATOM 17855 C SER D 91 -54. ,826 -5. ,734 -73. 171 1.00 38. ,54 D C

ATOM 17856 O SER D 91 -55. ,880 -5. ,126 -73. 048 1.00 39. ,53 D 0

ATOM 17858 N ASP D 92 -54. 347 -6. ,135 -74. 342 1.00 32. ,72 D N

ATOM 17859 CA ASP D 92 -55. 089 -5. 998 -75. 582 1.00 36. ,91 D c

ATOM 17861 CB ASP D 92 -54. ,201 -6. ,433 -76. ,750 1.00 35. ,09 D c

ATOM 17864 CG ASP D 92 -54. ,934 -6. ,422 -78. 059 1.00 28. 98 D c

ATOM 17865 ODl ASP D 92 -54. ,958 -5. ,370 -78. ,719 1.00 28. ,13 D 0

ATOM 17866 OD2 ASP D 92 -55. ,544 -7. ,448 -78. ,384 1.00 28. ,04 D 0

ATOM 17867 C ASP D 92 -56. ,366 -6. ,831 -75. 579 1.00 35. ,48 D c

ATOM 17868 O ASP D 92 -57. ,387 -6. ,408 -76. 067 1.00 37. ,44 D 0

ATOM 17870 N SER D 93 -56. 278 -8. ,023 -75. 027 1.00 40. ,76 D N

ATOM 17871 CA SER D 93 -57. 373 -8. 965 -75. 006 1.00 37. 36 D c

ATOM 17873 CB SER D 93 -57. ,637 -9. ,530 -76. ,409 1.00 36.63 D c

ATOM 17876 OG SER D 93 -56. ,416 -9. ,851 -77. ,070 1.00 34. ,50 D 0

ATOM 17878 C SER D 93 -56. 996 -10. ,076 -74. ,034 1.00 36. ,66 D c

ATOM 17879 O SER D 93 -55. ,848 -10. 183 -73. ,624 1.00 35. ,06 D 0

ATOM 17881 N LEU D 94 -57. ,977 -10. 900 -73. 682 1.00 36. ,84 D N

ATOM 17882 CA LEU D 94 -57.774 -12. Oil -72. 781 1.00 35. ,34 D c

ATOM 17884 CB LEU D 94 -59. 092 -12. 376 -72. 096 1.00 32. ,60 D c

ATOM 17887 CG LEU D 94 -59. 780 -11. ,257 -71.291 1.00 30. ,67 D c

ATOM 17889 CDl LEU D 94 -61.289 -11. ,530 -71. ,090 1.00 21. ,35 D c

ATOM 17893 CD2 LEU D 94 -59. ,091 -11. ,016 -69. 948 1.00 28. ,99 D c

ATOM 17897 C LEU D 94 -57. ,217 -13. ,190 -73. 589 1.00 36. 56 D c

ATOM 17898 O LEU D 94 -57. 611 -13. 392 -74. 729. 1.00 42. 67 D 0

ATOM 17900 N PRO D 95 -56. ,265 -13. ,952 -73. ,018 1.00 34. ,71 D N

ATOM 17901 CA PRO D 95 -55. ,605 -13. ,730 -71. 736 1.00 33. 38 D c

ATOM 17903 CB PRO D 95 -54. 955 -15. ,079 -71. ,455 1.00 30. ,17 D c

ATOM 17906 CG PRO D 95 -54. 650 -15. ,601 -72. ,772 1.00 30. ,63 D c

ATOM 17909 CD PRO D 95 -55. ,773 -15. ,177 -73. 667 1.00 30. ,19 D c

ATOM 17912 C PRO D 95 -54. ,531 -12. ,631 -71.811 1.00 34. ,64 D c

ATOM 17913 0 PRO D 95 -53. ,859 -12. ,491 -72. ,836 1.00 32. ,89 D 0

ATOM 17914 N TYR D 96 -54. ,392 -11. ,856 -70. ,735 1.00 32. ,70 D N

ATOM 17915 CA TYR D 96 -53. ,305 -10. ,903 -70. 626 1.00 31.75 D c

ATOM 17917 CB TYR D 96 -53. ,503 -9. ,971 -69. ,448 1.00 24. 26 D c

ATOM 17920 CG TYR D 96 -54. ,779 -9. ,143 -69. ,402 1.00 21.12 D c

ATOM 17921 CDl TYR D 96 -55. ,599 -8. ,942 -70. ,530 1.00 20. ,34 D c

ATOM 17923 CEl TYR D 96 -56. ,768 -8. ,124 -70. ,436 1.00 21.35 D c

ATOM 17925 cz TYR D 96 -57. ,086 -7. ,517 -69. ,200 1.00 23. ,00 D c

ATOM 17926 OH TYR D 96 -58. ,197 -6. ,705 -69. ,008 1.00 16. ,83 D 0

ATOM 17928 CE2 TYR D 96 -56. ,264 -7. ,720 -68. ,101 1.00 20. ,25 D c

ATOM 17930 CD2 TYR D 96 -55. ,131 -8. ,511 -68. ,209 1.00 18. ,13 D c

ATOM 17932 C TYR D 96 -51. ,970 -11. ,642 -70. ,451 1.00 32. ,27 D c

ATOM 17933 0 TYR D 96 -51. ,941 -12. ,846 -70. ,125 1.00 33. ,17 D 0

ATOM 17935 N THR D 97 -50. ,867 -10. .923 -70. ,667 1.00 31. .46 D N

ATOM 17936 CA THR D 97 -49. ,525 -11.533 -70. ,637 1.00 32. ,27 D c

ATOM 17938 CB THR D 97 -48. ,998 -11. ,845 -72. ,075 1.00 30. ,08 D c

ATOM 17940 OGl THR D 97 -50. ,069 -12. ,318 -72. ,895 1.00 30, ,94 D 0

ATOM 17942 CG2 THR D 97 -47. 830 -12, ,895 -72. ,037 1.00 27, ,91 D c

ATOM 17946 C THR D 97 -48. ,480 -10. ,624 -70. ,016 1.00 33. ,38 D c

ATOM 17947 0 THR D 97 -48. ,275 -9. ,505 -70. ,461 1.00 33. ,71 D 0

ATOM 17949 N PHE D 98 -47. ,785 -11. ,146 -69. ,018 1.00 34. ,96 D N

ATOM 17950 CA PHE D 98 -46. ,668 -10. ,468 -68, .390 1.00 34, .31 D c

ATOM 17952 CB PHE D 98 -46. ,383 -11. .075 -67, ,010 1.00 28, .87 D c

ATOM 17955 CG PHE D 98 -47. ,278 -10. .576 -65, ,921 1.00 29, ,73 D c

ATOM 17956 CDl PHE D 98 -47. ,133 -9. ,299 -65. ,420 1.00 29. .49 D c human fD_Fab

ATOM 17958 CEl PHE D 98 -47. 932 -8. 851 -64. ,394 1. 00 28. 57 D C

ATOM 17960 CZ PHE D 98 -48. 907 -9. 682 -63. ,865 1. 00 29. 03 D C

ATOM 17962 CE2 PHE D 98 -49. ,052 -10. 951 -64. ,351 1. 00 28. ,72 D C

ATOM 17964 CD2 PHE D 98 -48. ,228 -11. 403 -65. ,359 1. 00 29. ,83 D C

ATOM 17966 C PHE D 98 -45. ,389 -10. 601 -69. ,218 1. 00 35. 66 D C

ATOM 17967 O PHE D 98 -45. ,166 -11. 628 -69. 895 1. 00 34. 09 D 0

ATOM 17969 N GLY D 99 -44. ,541 -9. 570 -69. ,116 1. 00 35. 28 D N

ATOM 17970 CA GLY D 99 -43. 143 -9. 667 -69. ,487 1. 00 34. 03 D C

ATOM 17973 C GLY D 99 -42. 382 -10. 526 -68. ,492 1. 00 37. 03 D C

ATOM 17974 O GLY D 99 -42. ,886 -10. 846 -67. ,411 1. 00 35. ,75 D 0

ATOM 17976 N GLN D 100 -41. 169 -10. 908 -68. ,876 1. 00 36. 51 D N

ATOM 17977 CA GLN D 100 -40. 307 -11. 783 -68. ,072 1. 00 32. 76 D C

ATOM 17979 CB GLN D 100 -39. 147 -12. 289 -68. 940 1. 00 31. 39 D c

ATOM 17982 CG GLN D 100 -39. 593 -13. 169 -70. ,114 1. 00 34. 37 D c

ATOM 17985 CD GLN D 100 -39. 682 -12. 449 -71.471 1. 00 36. 27 D c

ATOM 17986 OEl GLN D 100 -40. 168 -11. 323 -71. ,581 1. 00 28. 09 D 0

ATOM 17987 NE2 GLN D 100 -39. 214 -13. 129 -72. ,519 1. 00 43. 08 D N

ATOM 17990 C GLN D 100 -39. 760 -11.114 -66. ,803 1. 00 34. 65 D c

ATOM 17991 O GLN D 100 -39. 328 -11. 791 -65. ,867 1. 00 39. 07 D 0

ATOM 17993 N GLY D 101 -39. 802 -9. 791 -66. ,771 1. 00 34. 98 D N

ATOM 17994 CA GLY D 101 -39. 353 -9. 009 -65. ,619 1. 00 33. 87 D c

ATOM 17997 C GLY D 101 -37. 988 -8. 377 -65. ,854 1. 00 32. 21 D c

ATOM 17998 O GLY D 101 -37. 188 -8. 891 -66. ,641 1. 00 32. 54 D 0

ATOM 18000 N THR D 102 -37. 737 -7. 256 -65. ,184 1. 00 32. 75 D N

ATOM 18001 CA THR D 102 -36. 412 -6. 627 -65. ,170 1. 00 31. 77 D c

ATOM 18003 CB THR D 102 -36. 327 -5. 351 -66. .068 1. 00 33. 86 D c

ATOM 18005 OGl THR D 102 -36. 593 -5. 663 -67. ,451 1. 00 29. 07 D 0

ATOM 18007 CG2 THR D 102 -34. 936 -4. 671 -65. ,943 1. 00 32. 97 D c

ATOM 18011 C THR D 102 -36. 054 -6. 227 -63. ,746 1. 00 32. 02 D c

ATOM 18012 O THR D 102 -36. 702 -5. 363 -63. ,158 1. 00 25. 82 D 0

ATOM 18014 N LYS D 103 -34. 995 -6. 842 -63. ,217 1. 00 31. 03 D N

ATOM 18015 CA LYS D 103 -34. 499 -6. 551 -61.894 1. 00 33. 08 D c

ATOM 18017 CB LYS D 103 -33. 695 -7. 744 -61. ,368 1. 00 36. 67 D c

ATOM 18020 CG LYS D 103 -33. 619 -7. 783 -59. ,847 1. 00 39. 34 D c

ATOM 18023 CD LYS D 103 -32. 527 -8. 675 -59. ,296 1. 00 41. 54 D c

ATOM 18026 CE LYS D 103 -32. 491 -8. 588 -57. ,748 1. 00 43. 89 D c

ATOM 18029 NZ LYS D 103 -31. 550 -9. 577 -57. ,114 1. 00 42. 75 D N

ATOM 18033 C LYS D 103 -33. 624 -5. 299 -61.944 1. 00 35. 12 D c

ATOM 18034 O LYS D 103 -32. 657 -5. 249 -62. 700 1. 00 36. 75 D 0

ATOM 18036 N VAL D 104 -33. 967 -4. 295 -61.136 1. 00 36. 46 D N

ATOM 18037 CA VAL D 104 -33. 277 -3. 024 -61. ,132 1. 00 32. 87 D c

ATOM 18039 CB VAL D 104 -34. 245 -1. ,859 -61.408 1. 00 31. ,34 D c

ATOM 18041 CGI VAL D 104 -33. 612 -0. ,545 -61. .003 1. 00 30. ,67 D c

ATOM 18045 CG2 VAL D 104 -34. 620 -1. ,821 -62. ,883 1. 00 20. 53 D c

ATOM 18049 C VAL D 104 -32. 564 -2. 837 -59. ,802 1. 00 39. 68 D c

ATOM 18050 O VAL D 104 -33. 194 -2. 840 -58. ,750 1. 00 37. 34 D 0

ATOM 18052 N GLU D 105 -31. 240 -2. 716 -59. ,862 1. 00 41. 34 D N

ATOM 18053 CA GLU D 105 -30. 411 -2. 529 -58. ,678 1. 00 45. 28 D C

ATOM 18055 CB GLU D 105 -29. 322 -3. 603 -58. ,615 1. 00 50. 44 D C

ATOM 18058 CG GLU D 105 -29. 835 -5. ,009 -58. ,870 1. 00 55. 09 D c

ATOM 18061 CD GLU D 105 -28. 871 -6. ,094 -58. ,380 1. 00 54. ,73 D c

ATOM 18062 OEl GLU D 105 -27. 698 -6. 104 -58. ,848 1. 00 56. ,90 D 0

ATOM 18063 OE2 GLU D 105 -29. 293 -6. 916 -57. ,520 1. 00 51. ,30 D 0

ATOM 18064 C GLU D 105 -29. 753 -1. ,152 -58. ,700 1. 00 43. ,14 D c

ATOM 18065 0 GLU D 105 -29. 573 -0. 557 -59. ,763 1. 00 37. 69 D 0

ATOM 18067 N ILE D 106 -29. 407 -0. 657 -57. ,516 1. 00 45. 95 D N

ATOM 18068 CA ILE D 106 -28. 734 0. 634 -57. ,372 1. 00 48. 69 D c

ATOM 18070 CB ILE D 106 -29. 322 1. ,447 -56. .202 1. 00 47. ,63 D c

ATOM 18072 CGl ILE D 106 -30. 695 2. ,016 -56. ,587 1. 00 50. ,17 D c

ATOM 18075 CDl ILE D 106 -30. 645 3. ,279 -57. .424 1. 00 50. ,66 D c

ATOM 18079 CG2 ILE D 106 -28. 368 2. ,543 -55. .786 1. 00 46. 30 D c

ATOM 18083 C ILE D 106 -27. 226 0. ,473 -57. ,157 1. 00 48. ,62 D c

ATOM 18084 0 ILE D 106 -26. 786 -0. 232 -56. .247 1. 00 44. ,17 D 0

ATOM 18086 N LYS D 107 -26. 449 1. ,132 -58. .015 1. 00 50. ,60 D N

ATOM 18087 CA LYS D 107 -25. 018 1. 283 -57. ,797 1. 00 52. ,54 D c

ATOM 18089 CB LYS D 107 -24. ,266 1. ,605 -59. .091 1. 00 54. ,87 D c

ATOM 18092 CG LYS D 107 -23. 287 0. ,537 -59. ,522 1. 00 60. ,07 D c

ATOM 18095 CD LYS D 107 -22. 245 1. ,091 -60. ,485 1. 00 62. ,78 D c human fD_Fab

ATOM 18098 CE LYS D 107 -21. 148 1. 894 -59. 765 1.00 65. ,59 D C

ATOM 18101 NZ LYS D 107 -20. 462 2. 871 -60. 680 1.00 61. 80 D N

ATOM 18105 C LYS D 107 -24. 787 2. 403 -56. 813 1.00 50. ,49 D C

ATOM 18106 O LYS D 107 -25. 221 3. 526 -57. 027 1.00 49. ,64 D 0

ATOM 18108 N ARG D 108 -24. 102 2. 094 -55. 727 1.00 49. ,37 D N

ATOM 18109 CA ARG D 108 -23. 777 3. 101 -54. 744 1.00 48. ,28 D C

ATOM 18111 CB ARG D 108 -24. 739 2. 987 -53. 549 1.00 44. ,17 D c

ATOM 18114 CG ARG D 108 -24. 816 1. 605 -52. 886 1.00 46. ,31 D c

ATOM 18117 CD ARG D 108 -24. 885 1. 710 -51. 352 1.00 46. ,78 D c

ATOM 18120 NE ARG D 108 -23. 745 2. 484 -50. 847 1.00 48. ,96 D N

ATOM 18122 CZ ARG D 108 -23. 669 3. 109 -49. 674 1.00 48. ,45 D c

ATOM 18123 NHl ARG D 108 -24. 671 3. 090 -48. 804 1.00 48. ,84 D N

ATOM 18126 NH2 ARG D 108 -22. 560 3. 771 -49. 379 1.00 48. ,31 D N

ATOM 18129 C ARG D 108 -22. 290 3. 003 -54. 346 1.00 48. ,47 D C

ATOM 18130 O ARG D 108 -21. 537 2. 171 -54. 859 1.00 47. 58 D 0

ATOM 18132 N THR D 109 -21. 867 3. 904 -53. 478 1.00 48. ,75 D N

ATOM 18133 CA THR D 109 -20. 532 3. 877 -52. 910 1.00 48. ,78 D C

ATOM 18135 CB THR D 109 -20. 405 5. 041 -51. 909 1.00 53. ,11 D c

ATOM 18137 OGl THR D 109 -19. 901 6. 194 -52. 596 1.00 54. ,13 D 0

ATOM 18139 CG2 THR D 109 -19. 482 4. 683 -50. 755 1.00 61.93 D c

ATOM 18143 C THR D 109 -20. 264 2. 581 -52. 170 1.00 48. ,97 D c

ATOM 18144 O THR D 109 -21. 175 2. 003 -51. 593 1.00 52. ,57 D 0

ATOM 18146 N VAL D 110 -19. 012 2. 129 -52. 169 1.00 49. ,80 D N

ATOM 18147 CA VAL D 110 -18. 607 0. 933 -51. 408 1.00 46. ,02 D c

ATOM 18149 CB VAL D 110 -17. 157 0. 527 -51. 754 1.00 47. ,49 D c

ATOM 18151 CGI VAL D 110 -17. 119 -0. 032 -53. 174 1.00 43. 94 D c

ATOM 18155 CG2 VAL D 110 -16. 591 -0. 477 -50. 746 1.00 47. 26 D c

ATOM 18159 C VAL D 110 -18. 750 1. 179 -49. 918 1.00 42. 35 D c

ATOM 18160 0 VAL D 110 -18. 277 2. 179 -49. 422 1.00 41.48 D 0

ATOM 18162 N ALA D 111 -19. 468 0. 296 -49. 225 1.00 45. 68 D N

ATOM 18163 CA ALA D 111 -19. 663 0. 399 -47. 786 1.00 44. 70 D c

ATOM 18165 CB ALA D 111 -21. 127 0. 599 -47. 459 1.00 32. ,24 D c

ATOM 18169 C ALA D 111 -19. 154 -0. 895 -47. 170 1.00 43. ,74 D c

ATOM 18170 0 ALA D 111 -19. 479 -1. 977 -47. 657 1.00 42. ,08 D 0

ATOM 18172 N ALA D 112 -18. 368 -0. 786 -46. 100 1.00 49. ,41 D N

ATOM 18173 CA ALA D 112 -17. 835 -1. 974 -45. 413 1.00 50. ,30 D c

ATOM 18175 CB ALA D 112 -16. 550 -1. 628 -44. 641 1.00 51. ,84 D c

ATOM 18179 C ALA D 112 -18. 902 -2. 510 -44. 465 1.00 49. ,43 D c

ATOM 18180 0 ALA D 112 -19. 675 -1. 740 -43. 920 1.00 52. ,03 D 0

ATOM 18182 N PRO D 113 -18. 959 -3. 834 -44. 279 1.00 49. ,18 D N

ATOM 18183 CA PRO D 113 -19. 959 -4. 400 -43. 387 1.00 48. ,41 D c

ATOM 18185 CB PRO D 113 -19. 947 -5. 892 -43. 753 1.00 48. ,78 D c

ATOM 18188 CG PRO D 113 -18. 611 -6. ,151 -44. 238 1.00 48, ,96 D c

ATOM 18191 CD PRO D 113 -18. 119 -4. 881 -44. ,890 1.00 49. .88 D c

ATOM 18194 C PRO D 113 -19. 562 -4. 226 -41. 939 1.00 47. ,38 D c

ATOM 18195 0 PRO D 113 -18. 385 -4. 316 -41.620 1.00 45. .70 D 0

ATOM 18196 N SER D 114 -20. 547 -4. 003 -41. 075 1.00 46. ,93 D N

ATOM 18197 CA SER D 114 -20. 328 -3. 989 -39. 654 1.00 46. ,41 D c

ATOM 18199 CB SER D 114 -21.238 -2. 957 -38. 988 1.00 52. ,60 D c

ATOM 18202 OG SER D 114 -22. 451 -3. 535 -38. 562 1.00 59. ,87 D 0

ATOM 18204 C SER D 114 -20. 625 -5. 418 -39. 237 1.00 47. ,10 D c

ATOM 18205 0 SER D 114 -21. 660 -5. ,957 -39. ,607 1.00 51. ,52 D 0

ATOM 18207 N VAL D 115 -19. 707 -6. ,060 -38. ,518 1.00 47. .05 D N

ATOM 18208 CA VAL D 115 -19. 800 -7. ,507 -38. ,302 1.00 44. .95 D c

ATOM 18210 CB VAL D 115 -18. 518 -8. ,194 -38. ,727 1.00 46. ,17 D c

ATOM 18212 CGI VAL D 115 -18. 702 -9. 728 -38. ,716 1.00 47. .07 D c

ATOM 18216 CG2 VAL D 115 -18. 120 -7. 676 -40. ,068 1.00 38. ,56 D c

ATOM 18220 C VAL D 115 -20. 071 -7. 872 -36. 867 1.00 43. ,13 D c

ATOM 18221 0 VAL D 115 -19. 444 -7. 330 -35. 965 1.00 43. ,68 D 0

ATOM 18223 N PHE D 116 -20. 996 -8. 807 -36. 667 1.00 44. ,64 D N

ATOM 18224 CA PHE D 116 -21. 436 -9. ,221 -35. 327 1.00 45. .30 D c

ATOM 18226 CB PHE D 116 -22. 807 -8. ,641 -35. ,007 1.00 51, .57 D c

ATOM 18229 CG PHE D 116 -22. 935 -7. ,166 -35. ,281 1.00 53, .39 D c

ATOM 18230 CDl PHE D 116 -22. 229 -6. 246 -34. ,526 1.00 56, .67 D c

ATOM 18232 CEl PHE D 116 -22. 362 -4. 881 -34. ,765 1.00 55. .24 D c

ATOM 18234 CZ PHE D 116 -23. 220 -4. 427 -35. ,750 1.00 53, ,16 D c

ATOM 18236 CE2 PHE D 116 -23. 934 -5. ,334 -36. ,510 1.00 52, ,45 D c

ATOM 18238 CD2 PHE D 116 -23. 787 -6. 695 -36. ,278 1.00 54. .45 D c human fD_Fab

ATOM 18240 C PHE D 116 -21. 520 -10. ,738 -35. ,217 1. 00 44. ,71 D C

ATOM 18241 O PHE D 116 -21.739 -11.441 -36. ,215 1. 00 44. ,01 D 0

ATOM 18243 N ILE D 117 -21. 341 -11. ,243 -34. ,002 1. 00 43. ,17 D N

ATOM 18244 CA ILE D 117 -21. 350 -12, .688 -33. .760 1. 00 44. ,64 D C

ATOM 18246 CB ILE D 117 -19. 911 -13. ,247 -33. ,512 1. 00 49. .99 D C

ATOM 18248 CGI ILE D 117 -19. 922 -14. .788 -33. ,443 1. 00 49. ,76 D c

ATOM 18251 CDl ILE D 117 -18. 608 -15. ,426 -33. ,893 1. 00 51. ,14 D c

ATOM 18255 CG2 ILE D 117 -19. 297 -12. ,629 -32. ,237 1. 00 42. ,81 D c

ATOM 18259 C ILE D 117 -22. 249 -12. ,971 -32. ,573 1. 00 42. ,52 D c

ATOM 18260 O ILE D 117 -22. 230 -12. ,227 -31.608 1. 00 42. ,09 D 0

ATOM 18262 N PHE D 118 -23. 047 -14. ,031 -32. ,672 1. 00 41. ,68 D N

ATOM 18263 CA PHE D 118 -23. 944 -14. .438 -31.595 1. 00 42. ,95 D c

ATOM 18265 CB PHE D 118 -25. 411 -14, .269 -31. ,972 1. 00 45. ,61 D c

ATOM 18268 CG PHE D 118 -25. 798 -12. ,870 -32. ,353 1. 00 43. ,69 D c

ATOM 18269 CDl PHE D 118 -26. 339 -12. .019 -31. ,418 1. 00 40. ,42 D c

ATOM 18271 CEl PHE D 118 -26. 713 -10. ,758 -31. .748 1. 00 40. ,90 D c

ATOM 18273 CZ PHE D 118 -26. 569 -10. ,319 -33. ,032 1. 00 45. ,60 D c

ATOM 18275 CE2 PHE D 118 -26. 042 -11. ,161 -33. ,992 1. 00 46. ,95 D c

ATOM 18277 CD2 PHE D 118 -25. 670 -12. ,436 -33. ,653 1. 00 41. ,44 D c

ATOM 18279 C PHE D 118 -23. 746 -15. ,912 -31. ,256 1. 00 47. ,23 D c

ATOM 18280 O PHE D 118 -23. 940 -16, .773 -32. ,121 1. 00 44. ,40 D 0

ATOM 18282 N PRO D 119 -23. 334 -16, .217 -30. ,008 1. 00 48. ,90 D N

ATOM 18283 CA PRO D 119 -23. 277 -17. .624 -29. ,607 1. 00 47. ,56 D c

ATOM 18285 CB PRO D 119 -22. 695 -17. .587 -28. ,182 1. 00 48. ,79 D c

ATOM 18288 CG PRO D 119 -22. 681 -16. ,177 -27. ,765 1. 00 48. ,20 D c

ATOM 18291 CD PRO D 119 -22. 810 -15. ,314 -28. ,968 1. 00 50. ,04 D c

ATOM 18294 C PRO D 119 -24. 628 -18. ,299 -29. ,562 1. 00 47. ,18 D c

ATOM 18295 0 PRO D 119 -25. 655 -17. ,635 -29. ,538 1. 00 50. ,01 D 0

ATOM 18296 N PRO D 120 -24. 634 -19. ,634 -29. ,484 1. 00 47. ,40 D N

ATOM 18297 CA PRO D 120 -25. 898 -20, .298 -29. ,229 1. 00 49. ,07 D c

ATOM 18299 CB PRO D 120 -25. 516 -21, ,778 -29. ,117 1. 00 50. ,47 D c

ATOM 18302 CG PRO D 120 -24. 184 -21, .900 -29. ,718 1. 00 49. ,75 D c

ATOM 18305 CD PRO D 120 -23. 517 -20. .578 -29. ,597 1. 00 44. .98 D c

ATOM 18308 C PRO D 120 -26. 508 -19. ,829 -27. ,912 1. 00 52. ,79 D c

ATOM 18309 0 PRO D 120 -25. 783 -19. ,536 -26. ,962 1. 00 54. ,40 D 0

ATOM 18310 N SER D 121 -27. 832 -19. ,762 -27. ,876 1. 00 54. ,95 D N

ATOM 18311 CA SER D 121 -28. 583 -19. ,459 -26. ,662 1. 00 52. 08 D c

ATOM 18313 CB SER D 121 -30. 037 -19, .101 -27. ,020 1. 00 52. ,06 D c

ATOM 18316 OG SER D 121 -30. 788 -20, .264 -27. ,399 1. 00 51. ,54 D 0

ATOM 18318 C SER D 121 -28. 569 -20, .675 -25. ,734 1. 00 54. .84 D c

ATOM 18319 0 SER D 121 -28. 492 -21, .828 -26. ,197 1. 00 55. ,38 D 0

ATOM 18321 N ASP D 122 -28. 653 -20, .412 -24, ,430 1. 00 55. ,31 D N

ATOM 18322 CA ASP D 122 -28. 676 -21, .476 -23. ,431 1. 00 57. ,41 D c

ATOM 18324 CB ASP D 122 -28. 797 -20. .899 -22. ,005 1. 00 64. ,12 D c

ATOM 18327 CG ASP D 122 -27. 613 -20, .013 -21. ,611 1. 00 68. ,20 D c

ATOM 18328 ODl ASP D 122 -26. 453 -20. .407 -21.863 1. 00 67. ,83 D 0

ATOM 18329 OD2 ASP D 122 -27. 850 -18, .917 -21, .049 1. 00 71, ,94 D 0

ATOM 18330 C ASP D 122 -29. ,840 -22, .412 -23, ,690 1. 00 55. .89 D c

ATOM 18331 0 ASP D 122 -29. 729 -23, .624 -23, .490 1. 00 56. ,44 D 0

ATOM 18333 N GLU D 123 -30. 962 -21, .842 -24, .119 1. 00 55. .62 D N

ATOM 18334 CA GLU D 123 -32. 163 -22, .639 -24. .365 1. 00 58. .19 D c

ATOM 18336 CB GLU D 123 -33. 426 -21.778 -24, .324 1. 00 62. .28 D c

ATOM 18339 CG GLU D 123 -33. 600 -20, .844 -25. .453 1. 00 64. ,70 D c

ATOM 18342 CD GLU D 123 -34. 523 -19, .708 -25. .097 1. 00 66. ,14 D c

ATOM 18343 OEl GLU D 123 -34. 026 -18, .682 -24, .558 1. 00 65, .09 D 0

ATOM 18344 OE2 GLU D 123 -35. ,738 -19, .850 -25, ,372 1. 00 68, .76 D 0

ATOM 18345 C GLU D 123 -32. ,103 -23, .514 -25, .624 1. 00 55, ,92 D c

ATOM 18346 0 GLU D 123 -32. ,788 -24, .541 -25, ,681 1. 00 57, ,81 D 0

ATOM 18348 N GLN D 124 -31. 273 -23, .151 -26, ,607 1. 00 53, ,51 D N

ATOM 18349 CA GLN D 124 -31. 107 -24, .016 -27, .783 1. 00 53, ,71 D c

ATOM 18351 CB GLN D 124 -30. 524 -23, .284 -28, .991 1. 00 53. ,16 D c

ATOM 18354 CG GLN D 124 -30. 644 -24, .108 -30, .262 1. 00 48, ,06 D c

ATOM 18357 CD GLN D 124 -29. 780 -23, .623 -31, .405 1. 00 48, ,64 D c

ATOM 18358 OEl GLN D 124 -29. ,041 -22, .624 -31, .292 1. 00 46, .14 D 0

ATOM 18359 NE2 GLN D 124 -29. ,850 -24, .351 -32, .529 1. 00 42, .72 D N

ATOM 18362 C GLN D 124 -30. 231 -25, .201 -27, .456 1. 00 54, .06 D c

ATOM 18363 0 GLN D 124 -30. 529 -26, .316 -27, .879 1. 00 54, .95 D 0

ATOM 18365 N LEU D 125 -29. 141 -24, .956 -26, .727 1. 00 59, .84 D N human fD _Fab

ATOM 18366 CA LEU D 125 -28.277 -26. 037 -26. 226 1. 00 61.75 D C

ATOM 18368 CB LEU D 125 -27.276 -25. 478 -25. 222 1. 00 62. 46 D C

ATOM 18371 CG LEU D 125 -26.009 -24. 805 -25. 753 1. 00 64. 31 D C

ATOM 18373 CDl LEU D 125 -25.866 -24. 893 -27. 275 1. 00 63. 47 D C

ATOM 18377 CD2 LEU D 125 -25.958 -23. 360 -25. 256 1. 00 61. 72 D C

ATOM 18381 C LEU D 125 -29.097 -27. 150 -25. 568 1. 00 62. 59 D C

ATOM 18382 O LEU D 125 -28.865 -28. 325 -25. 823 1. 00 61.70 D 0

ATOM 18384 N LYS D 126 -30.062 -26. 771 -24. 736 1. 00 67. 78 D N

ATOM 18385 CA LYS D 126 -30.997 -27. 730 -24. 118 1. 00 72. 70 D C

ATOM 18387 CB LYS D 126 -32.175 -26. 997 -23. 449 1. 00 77. 92 D C

ATOM 18390 CG LYS D 126 -32.220 -27. 117 -21. 924 1. 00 80. 68 D c

ATOM 18393 CD LYS D 126 -33.156 -26. 084 -21.280 1. 00 81. 68 D c

ATOM 18396 CE LYS D 126 -32.459 -24. 729 -21. 062 1. 00 85. 53 D c

ATOM 18399 NZ LYS D 126 -31.336 -24. 777 -20. 062 1. 00 85. 48 D N

ATOM 18403 C LYS D 126 -31.537 -28. 755 -25. 124 1. 00 74. 92 D c

ATOM 18404 0 LYS D 126 -31.523 -29. 959 -24. 864 1. 00 75. 64 D 0

ATOM 18406 N SER D 127 -31.988 -28. 261 -26. 278 1. 00 75. 06 D N

ATOM 18407 CA SER D 127 -32. 573 -29. 093 -27. 336 1. 00 70. 35 D c

ATOM 18409 CB SER D 127 -33.183 -28. 194 -28. 428 1. 00 72. 55 D C

ATOM 18412 OG SER D 127 -33.792 -27. 027 -27. 894 1. 00 71. 46 D 0

ATOM 18414 C SER D 127 -31. 582 -30. 066 -28. 010 1. 00 69. 14 D c

ATOM 18415 0 SER D 127 -32.003 -30. 979 -28. 718 1. 00 68. 81 D 0

ATOM 18417 N GLY D 128 -30.280 -29. 854 -27. 829 1. 00 67. 21 D N

ATOM 18418 CA GLY D 128 -29.263 -30. 745 -28. 383 1. 00 65. 51 D C

ATOM 18421 C GLY D 128 -28. 547 -30. 227 -29. 627 1. 00 66. 52 D c

ATOM 18422 0 GLY D 128 -27.847 -31. 000 -30. , 314 1. 00 63. 87 D 0

ATOM 18424 N THR D 129 -28.686 -28. 930 -29. 919 1. 00 66. 07 D N

ATOM 18425 CA THR D 129 -28.019 -28. 341 -31.089 1. 00 62. 22 D c

ATOM 18427 CB THR D 129 -28.942 -28. 387 -32. 324 1. 00 65. 78 D c

ATOM 18429 OGl THR D 129 -28.163 -28. 160 -33. 503 1. 00 66. 93 D 0

ATOM 18431 CG2 THR D 129 -30.062 -27. 336 -32. 220 1. 00 68. 68 D c

ATOM 18435 C THR D 129 -27. 514 -26. 908 -30. 816 1. 00 56. 03 D c

ATOM 18436 0 THR D 129 -28.041 -26. 224 -29. 945 1. 00 54. 82 D 0

ATOM 18438 N ALA D 130 -26.474 -26. 485 -31. 540 1. 00 53. 04 D N

ATOM 18439 CA ALA D 130 -25.919 -25. 121 -31. 421 1. 00 50. 06 D c

ATOM 18441 CB ALA D 130 -24. 541 -25. 140 -30. 790 1. 00 47. 66 D c

ATOM 18445 C ALA D 130 -25.828 -24. 416 -32. 769 1. 00 48. 89 D c

ATOM 18446 0 ALA D 130 -25.081 -24. 853 -33. 647 1. 00 50. 81 D 0

ATOM 18448 N SER D 131 -26. 574 -23. 317 -32. 921 1. 00 47. 18 D N

ATOM 18449 CA SER D 131 -26.402 -22. 410 -34. 064 1. 00 44. 34 D c

ATOM 18451 CB SER D 131 -27.751 -22. 025 -34. 701 1. 00 43. 12 0 c

ATOM 18454 OG SER D 131 -28. 591 -23. 163 -34. 940 1. 00 40. 64 D 0

ATOM 18456 C SER D 131 -25.603 -21.159 -33. , 648 1. 00 38. 56 D c

ATOM 18457 0 SER D 131 -25.992 -20. 429 -32. , 749 1. 00 40. 05 D 0

ATOM 18459 N VAL D 132 -24.468 -20. 943 -34. 296 1. 00 39. 66 D N

ATOM 18460 CA VAL D 132 -23.684 -19. 717 -34. 138 1. 00 41. 65 D c

ATOM 18462 CB VAL D 132 -22.184 -20. 018 -34. 032 1. 00 43. 51 D c

ATOM 18464 CGI VAL D 132 -21.472 -18. 849 -33. 387 1. 00 41.74 D c

ATOM 18468 CG2 VAL D 132 -21.953 -21. , 300 -33. , 245 1. 00 39. 53 D c

ATOM 18472 C VAL D 132 -23.954 -18. 808 -35. , 355 1. 00 43. 34 D c

ATOM 18473 0 VAL D 132 -23.757 -19. 223 -36. ,495 1. 00 38. 74 D 0

ATOM 18475 N VAL D 133 -24.427 -17. 586 -35. , 106 1. 00 43. 53 D N

ATOM 18476 CA VAL D 133 -24.842 -16. , 683 -36. , 172 1. 00 41. 20 D c

ATOM 18478 CB VAL D 133 -26.276 -16. 117 -35. , 905 1. 00 42. 10 D c

ATOM 18480 CGI VAL D 133 -26.630 -14. 981 -36. , 875 1. 00 34. 42 D c

ATOM 18484 CG2 VAL D 133 -27.351 -17. 243 -35. 979 1. 00 40. 63 D c

ATOM 18488 C VAL D 133 -23.823 -15. , 549 -36. , 346 1. 00 44. 08 D c

ATOM 18489 0 VAL D 133 -23.421 -14. , 892 -35. , 373 1. 00 41. , 37 D 0

ATOM 18491 N CYS D 134 -23.404 -15. , 334 -37. , 590 1. 00 46. , 73 D N

ATOM 18492 CA CYS D 134 -22. 563 -14. , 197 -37. , 955 1. 00 43. , 71 D c

ATOM 18494 CB CYS D 134 -21.352 -14. , 687 -38. , 731 1. 00 44. 38 D c

ATOM 18497 SG CYS D 134 -20.072 -13. ,455 -38. , 867 1. 00 55. 55 D S

ATOM 18499 C CYS D 134 -23.377 -13. 200 -38. , 803 1. 00 42. 93 D c

ATOM 18500 0 CYS D 134 -23.896 -13. , 558 -39. , 852 1. 00 41. 41 D 0

ATOM 18502 N LEU D 135 -23.491 -11. , 962 -38. , 337 1. 00 40. 84 D N

ATOM 18503 CA LEU D 135 -24.225 -10. 945 -39. 041 1. 00 40. , 98 D c

ATOM 18505 CB LEU D 135 -25.187 -10. 232 -38. 087 1. 00 44. , 17 D c

ATOM 18508 CG LEU D 135 -26.031 -9. 075 -38. , 641 1. 00 42. , 85 D c human fD_Fab

ATOM 18510 CDl LEU D 135 -26. .989 -9. 570 -39. 752 1. 00 41. ,49 D C

ATOM 18514 CD2 LEU D 135 -26. ,799 -8. 362 -37. 518 1. 00 43. ,06 D C

ATOM 18518 C LEU D 135 -23. ,262 -9. 948 -39. 679 1. 00 43. ,79 D C

ATOM 18519 O LEU D 135 -22. ,476 -9. 326 -38. 983 1. 00 41. ,25 D 0

ATOM 18521 N LEU D 136 -23. .344 -9. 826 -41. 012 1. 00 45. ,29 D N

ATOM 18522 CA LEU D 136 -22. ,710 -8. 758 -41. 773 1. 00 40. ,38 D C

ATOM 18524 CB LEU D 136 -22. ,117 -9. 311 -43. 072 1. 00 36. ,77 D C

ATOM 18527 CG LEU D 136 -20. ,806 -10. 113 -43. 047 1. 00 40. ,06 D c

ATOM 18529 CDl LEU D 136 -20. ,878 -11.399 -42. 268 1. 00 39. ,49 D c

ATOM 18533 CD2 LEU D 136 -20. ,367 -10. 417 -44. 494 1. 00 40. ,98 D c

ATOM 18537 C LEU D 136 -23. ,771 -7. 725 -42. 114 1. 00 42. 80 D c

ATOM 18538 O LEU D 136 -24. ,605 -7. 964 -42. 980 1. 00 44. ,75 D 0

ATOM 18540 N ASN D 137 -23. ,720 -6. 561 -41. 484 1. 00 43. ,51 D N

ATOM 18541 CA ASN D 137 -24. ,801 -5. 588 -41. 585 1. 00 41. ,88 D c

ATOM 18543 CB ASN D 137 -25. ,182 -5. 126 -40. 176 1. 00 47. ,84 D c

ATOM 18546 CG ASN D 137 -26. ,648 -4. 704 -40. 052 1. 00 51. ,40 D c

ATOM 18547 OOl ASN D 137 -27. ,550 -5. 363 -40. 562 1. 00 51. 20 D 0

ATOM 18548 ND2 ASN D 137 -26. ,882 -3. 616 -39. 329 1. 00 56. 40 D N

ATOM 18551 C ASN D 137 -24. ,480 -4. 372 -42. 475 1. 00 43. ,45 D c

ATOM 18552 0 ASN D 137 -23. ,418 -3. 773 -42. 372 1. 00 43. 05 D 0

ATOM 18554 N ASN D 138 -25. ,420 -4. 025 -43. 354 1. 00 45. ,14 D N

ATOM 18555 CA ASN D 138 -25. ,376 -2. 794 -44. 161 1. 00 43. 22 D c

ATOM 18557 CB ASN D 138 -25. ,681 -1. 574 -43. 286 1. 00 48. ,14 D c

ATOM 18560 CG ASN D 138 -27. ,124 -1. 544 -42. 820 1. 00 52. 82 D c

ATOM 18561 OOl ASN D 138 -27. 667 -2. 552 -42. 370 1. 00 54. 37 D 0

ATOM 18562 ND2 ASN D 138 -27. 761 -0. 387 -42. 955 1. 00 56. 21 D N

ATOM 18565 C ASN D 138 -24. ,104 -2. 565 -44. 987 1. 00 42. ,34 D c

ATOM 18566 0 ASN D 138 -23. ,429 -1. 561 -44. 813 1. 00 43. ,45 D 0

ATOM 18568 N PHE D 139 -23. 816 -3. 488 -45. 908 1. 00 40. ,13 D N

ATOM 18569 CA PHE D 139 -22. ,653 -3. 388 -46. 810 1. 00 41. ,60 D C

ATOM 18571 CB PHE D 139 -21. ,668 -4. 566 -46. 578 1. 00 39. 86 D C

ATOM 18574 CG PHE D 139 -22. 255 -5. 921 -46. 871 1. 00 39. 31 D c

ATOM 18575 CDl PHE D 139 -22. 184 -6. 459 -48. 151 1. 00 41. 64 D c

ATOM 18577 CEl PHE D 139 -22. ,759 -7. 695 -48. 444 1. 00 40. 93 D c

ATOM 18579 CZ PHE D 139 -23. 393 -8. 412 -47. 445 1. 00 38. ,97 D c

ATOM 18581 CE2 PHE D 139 -23. ,472 -7. 887 -46. 171 1. 00 40. ,10 D c

ATOM 18583 CD2 PHE D 139 -22. 910 -6. 644 -45. 886 1. 00 39. ,21 D c

ATOM 18585 C PHE D 139 -23. ,047 -3. 296 -48. 308 1. 00 42. ,78 D c

ATOM 18586 0 PHE D 139 -24. ,157 -3. 678 -48. 709 1. 00 42. ,60 D 0

ATOM 18588 N TYR D 140 -22. 119 -2. 767 -49. 111 1. 00 44. ,31 D N

ATOM 18589 CA TYR D 140 -22. ,228 -2. 727 -50. 572 1. 00 41. ,48 D c

ATOM 18591 CB TYR D 140 -22. ,944 -1. 452 -51. 067 1. 00 46. ,96 D c

ATOM 18594 CG TYR D 140 -23. ,182 -1. 492 -52. 574 1. 00 47. ,48 D c

ATOM 18595 CDl TYR D 140 -24. ,348 -2. 042 -53. 094 1. 00 45. ,73 D c

ATOM 18597 CEl TYR D 140 -24. ,562 -2. 126 -54. 452 1. 00 46. ,82 D c

ATOM 18599 CZ TYR D 140 -23. ,597 -1. 685 -55. 331 1. 00 48. ,00 D c

ATOM 18600 OH TYR D 140 -23. ,833 -1. 786 -56. 678 1. 00 44. ,85 D 0

ATOM 18602 CE2 TYR D 140 -22. 410 -1. 143 -54. 853 1. 00 49. ,95 D c

ATOM 18604 CD2 TYR D 140 -22. ,210 -1. 048 -53. ,473 1. 00 49. ,47 D c

ATOM 18606 C TYR D 140 -20. ,808 -2. 770 -51. ,149 1. 00 40. .36 D c

ATOM 18607 0 TYR D 140 -19. ,950 -2. 040 -50. 700 1. 00 42. .57 D 0

ATOM 18609 N PRO D 141 -20. ,559 -3. 583 -52. 181 1. 00 44. 53 D N

ATOM 18610 CA PRO D 141 -21. ,454 -4. 444 -52. 977 1. 00 47. ,71 D c

ATOM 18612 CB PRO D 141 -20. ,633 -4. 700 -54. 260 1. 00 48. 83 D c

ATOM 18615 CG PRO D 141 -19. ,224 -4. 647 -53. 819 1. 00 47. 07 D c

ATOM 18618 CD PRO D 141 -19. ,175 -3. 628 -52. ,691 1. 00 47. ,42 D c

ATOM 18621 C PRO D 141 -21. ,861 -5. 784 -52. 332 1. 00 45. .07 D c

ATOM 18622 0 PRO D 141 -21. ,411 -6. 119 -51. ,241 1. 00 45. ,77 D 0

ATOM 18623 N ARG D 142 -22. ,712 -6. 515 -53. ,047 1. 00 49. .42 D N

ATOM 18624 CA ARG D 142 -23. ,379 -7. 746 -52. ,597 1. 00 50. .28 D c

ATOM 18626 CB ARG D 142 -24. ,373 -8. 167 -53. 715 1. 00 56.97 D c

ATOM 18629 CG ARG D 142 -24. ,939 -9. 597 -53. 755 1. 00 59. ,47 D c

ATOM 18632 CD ARG D 142 -26. .047 -9. 829 -52. ,742 1. 00 65. .69 D c

ATOM 18635 NE ARG D 142 -26. ,970 -10. ,899 -53. ,149 1. 00 68. ,78 D N

ATOM 18637 CZ ARG D 142 -26. 727 -12. 212 -53. ,054 1. 00 72. ,51 D c

ATOM 18638 NHl ARG D 142 -25. ,568 -12. 664 -52. ,573 1. 00 73. ,78 D N

ATOM 18641 NH2 ARG D 142 -27. ,651 -13. 088 -53. ,450 1. 00 70. ,41 D N

ATOM 18644 C ARG D 142 -22. ,389 -8. 867 -52. ,286 1. ,00 50. ,69 D C human fD_Fab

ATOM 18645 O ARG D 142 -22. ,636 -9. ,712 -51.433 1.00 50. ,73 D 0

ATOM 18647 N GLU D 143 -21. ,268 -8. ,876 -52. 988 1.00 52. ,06 D N

ATOM 18648 CA GLU D 143 -20. 314 -9. ,975 -52. 898 1.00 50. 85 D C

ATOM 18650 CB GLU D 143 -19. 337 -9. ,949 -54. 081 1.00 57. ,73 D C

ATOM 18653 CG GLU D 143 -20. 005 -9. ,965 -55. 479 1.00 61. ,88 D c

ATOM 18656 CD GLU D 143 -20. 471 -8. ,583 -55. 969 1.00 62. ,73 D c

ATOM 18657 OEl GLU D 143 -19. 688 -7. ,601 -55. 900 1.00 63. 86 D 0

ATOM 18658 OE2 GLU D 143 -21. 622 -8. ,497 -56. 442 1.00 62. ,25 D 0

ATOM 18659 C GLU D 143 -19. 529 -9. ,875 -51.604 1.00 48. , 88 D c

ATOM 18660 O GLU D 143 -18. 828 -8. ,878 -51. 382 1.00 47. , 99 D 0

ATOM 18662 N ALA D 144 -19. 671 -10.903 -50. 763 1.00 45. ,40 D N

ATOM 18663 CA ALA D 144 -18. 956 -11. ,025 -49. 483 1.00 46. ,71 D c

ATOM 18665 CB ALA D 144 -19. 837 -10. ,551 -48. 306 1.00 37. ,77 D c

ATOM 18669 C ALA D 144 -18. 511 -12. ,488 -49. 272 1.00 45. ,16 D c

ATOM 18670 O ALA D 144 -19. 118 -13. ,406 -49. 799 1.00 46. ,90 D 0

ATOM 18672 N LYS D 145 -17. 443 -12. ,691 -48. 507 1.00 49. ,41 D N

ATOM 18673 CA LYS D 145 -16. 943 -14. ,041 -48. 187 1.00 51.18 D c

ATOM 18675 CB LYS D 145 -15. 498 -14. ,176 -48. 691 1.00 57. ,21 D c

ATOM 18678 CG LYS D 145 -15. 133 -15. 510 -49. 355 1.00 62. ,87 D c

ATOM 18681 CD LYS D 145 -14. 411 -16. ,491 -48. 395 1.00 63. ,09 D c

ATOM 18684 CE LYS D 145 -13. 286 -17. ,248 -49. 098 1.00 61. ,79 D c

ATOM 18687 NZ LYS D 145 -12. 479 -18. ,082 -48. 156 1.00 64. ,44 D N

ATOM 18691 C LYS D 145 -16. 975 -14. ,222 -46. 675 1.00 47. ,70 D c

ATOM 18692 O LYS D 145 -16. 409 -13. ,416 -45. 956 1.00 43. 19 D 0

ATOM 18694 N VAL D 146 -17. 658 -15. ,251 -46. 188 1.00 51.30 D N

ATOM 18695 CA VAL D 146 -17. 648 -15. ,560 -44. 764 1.00 52. 74 D c

ATOM 18697 CB VAL D 146 -19. 064 -15. ,526 -44. 184 1.00 53. 80 D c

ATOM 18699 CGl VAL D 146 -19. 071 -16. ,005 -42. 735 1.00 51. ,44 D c

ATOM 18703 CG2 VAL D 146 -19. 634 -14. ,106 -44. 300 1.00 53. 70 D c

ATOM 18707 C VAL D 146 -16. 983 -16. ,915 -44. 567 1.00 53. ,07 D c

ATOM 18708 O VAL D 146 -17. 305 -17. ,876 -45. 261 1.00 55. ,41 D 0

ATOM 18710 N GLN D 147 -16. 014 -16. ,974 -43. 661 1.00 55. ,53 D N

ATOM 18711 CA GLN D 147 -15. 268 -18. ,212 -43. 396 1.00 56. ,67 D c

ATOM 18713 CB GLN D 147 -13. 817 -18. ,102 -43. 900 1.00 64. ,74 D c

ATOM 18716 CG GLN D 147 -12. 950 -19. ,384 -43. 735 1.00 67. ,54 D c

ATOM 18719 CD GLN D 147 -13. 414 -20. ,569 -44. 600 1.00 73. 92 D c

ATOM 18720 OEl GLN D 147 -13. 352 -20. ,521 -45. 844 1.00 74. ,05 D 0

ATOM 18721 NE2 GLN D 147 -13. 872 -21.643 -43. 938 1.00 72. ,53 D N

ATOM 18724 C GLN D 147 -15. 297 -18. ,464 -41.901 1.00 55. ,49 D c

ATOM 18725 0 GLN D 147 -14. 991 -17. ,563 -41. 112 1.00 53. ,56 D 0

ATOM 18727 N TRP D 148 -15. 692 -19. ,684 -41.519 1.00 53. ,63 D N

ATOM 18728 CA TRP D 148 -15. 818 -20. ,032 -40. 109 1.00 52. ,80 D c

ATOM 18730 CB TRP D 148 -17. 052 -20. ,888 -39. 875 1.00 48. ,18 D c

ATOM 18733 CG TRP D 148 -18. 302 -20. ,103 -39. 801 1.00 47. ,98 D c

ATOM 18734 CDl TRP D 148 -19. 218 -19. ,910 -40. ,803 1.00 46. ,02 D c

ATOM 18736 NEl TRP D 148 -20. 243 -19. ,143 -40. ,356 1.00 43. ,61 D N

ATOM 18738 CE2 TRP D 148 -20. 024 -18. ,813 -39. ,048 1.00 45. ,62 D c

ATOM 18739 CD2 TRP D 148 -18. 802 -19. ,415 -38. ,663 1.00 45. ,98 D c

ATOM 18740 CE3 TRP D 148 -18. 342 -19, ,238 -37. ,357 1.00 45. , 11 D c

ATOM 18742 CZ3 TRP D 148 -19. 121 -18. ,485 -36. ,478 1.00 47. ,04 D c

ATOM 18744 CH2 TRP D 148 -20. 334 -17, ,902 -36. 896 1.00 46. ,95 D c

ATOM 18746 CZ2 TRP D 148 -20. 802 -18. ,061 -38. ,168 1.00 45. ,51 D c

ATOM 18748 C TRP D 148 -14. 589 -20, .776 -39. 619 1.00 50. ,48 D c

ATOM 18749 0 TRP D 148 -14. 020 -21. ,585 -40. 339 1.00 48. ,22 D 0

ATOM 18751 N LYS D 149 -14. 202 -20. ,499 -38. ,379 1.00 53. ,84 D N

ATOM 18752 CA LYS D 149 -13. 105 -21.204 -37. 732 1.00 56, ,32 D c

ATOM 18754 CB LYS D 149 -11. 838 -20. ,337 -37. ,753 1.00 60. ,90 D c

ATOM 18757 CG LYS D 149 -11. 353 -20. ,055 -39. 189 1.00 62. , 88 D c

ATOM 18760 CD LYS D 149 -9. 906 -19. ,550 -39. 281 1.00 63, ,82 D c

ATOM 18763 CE LYS D 149 -9. 805 -18. .067 -39. ,674 1.00 68, ,35 D c

ATOM 18766 NZ LYS D 149 -8. 661 -17. .812 -40. ,616 1.00 66. .35 D N

ATOM 18770 C LYS D 149 -13. 509 -21.604 -36. 312 1.00 54, .28 D c

ATOM 18771 0 LYS D 149 -14. Oil -20. .781 -35. 532 1.00 52, ,00 D 0

ATOM 18773 N VAL D 150 -13. 343 -22. , 888 -36. ,010 1.00 54. .95 D N

ATOM 18774 CA VAL D 150 -13. 563 -23. ,428 -34. ,652 1.00 55. ,83 D c

ATOM 18776 CB VAL D 150 -14. 598 -24. ,606 -34. ,618 1.00 54, ,86 D c

ATOM 18778 CGl VAL D 150 -14. 974 -24. .951 -33. ,172 1.00 46, .52 D c

ATOM 18782 CG2 VAL D 150 -15. 839 -24, ,264 -35. ,445 1.00 53, .42 D c human fD_Fab

ATOM 18786 C VAL D 150 -12. 203 -23. ,904 -34. 139 1. 00 55. 57 D C

ATOM 18787 O VAL D 150 -11.554 -24. ,753 -34. 779 1. 00 54. 79 D 0

ATOM 18789 N ASP D 151 -11. ,780 -23, .333 -33. 008 1. 00 57. 22 D N

ATOM 18790 CA ASP D 151 -10. ,409 -23, .459 -32. 510 1. 00 58. 24 D C

ATOM 18792 CB ASP D 151 -10. ,261 -24. .754 -31. 685 1. 00 58. 39 D C

ATOM 18795 CG ASP D 151 -10. ,844 -24. .615 -30. 277 1. 00 58. 50 D C

ATOM 18796 ODl ASP D 151 -10. ,806 -23. .505 -29. 723 1. 00 55. 69 D 0

ATOM 18797 002 ASP D 151 -11. 342 -25. .608 -29. 715 1. 00 60. 39 D 0

ATOM 18798 C ASP D 151 -9. 376 -23. ,337 -33. 652 1. 00 57. 72 D c

ATOM 18799 0 ASP D 151 -8. 420 -24. ,110 -33. 743 1. 00 57. 00 D 0

ATOM 18801 N ASN D 152 -9. 595 -22. ,347 -34. 514 1. 00 58. 08 D N

ATOM 18802 CA ASN D 152 -8. ,743 -22, .069 -35. 684 1. 00 59. 47 D c

ATOM 18804 CB ASN D 152 -7. ,334 -21, .656 -35. 253 1. 00 64. 36 D c

ATOM 18807 CG ASN D 152 -7. ,304 -20. .272 -34. 654 1. 00 69. 46 D c

ATOM 18808 ODl ASN D 152 -7. 246 -19. .282 -35. 377 1. 00 75. 92 D 0

ATOM 18809 ND2 ASN D 152 -7. ,350 -20. ,192 -33. 325 1. 00 69. 67 D N

ATOM 18812 C ASN D 152 -8. 689 -23. ,156 -36. 772 1. 00 59. 21 D c

ATOM 18813 0 ASN D 152 -7. 855 -23. ,085 -37. 684 1. 00 60. 62 D 0

ATOM 18815 N ALA D 153 -9. 600 -24, .126 -36. 699 1. 00 58. 73 D N

ATOM 18816 CA ALA D 153 -9. 778 -25, ,115 -37. 762 1. 00 59. 76 D c

ATOM 18818 CB ALA D 153 -10. ,150 -26, .478 -37. 164 1. 00 59. 10 D c

ATOM 18822 C ALA D 153 -10. ,869 -24, .644 -38. 736 1. 00 60. 84 D c

ATOM 18823 0 ALA D 153 -12. ,047 -24, .545 -38. 373 1. 00 61. 02 D 0

ATOM 18825 N LEU D 154 -10. 466 -24, ,360 -39. 967 1. 00 57. 81 D N

ATOM 18826 CA LEU D 154 -11.378 -23. ,861 -40. 996 1. 00 57. 44 D c

ATOM 18828 CB LEU D 154 -10. 613 -23. ,599 -42. 302 1. 00 56. 66 D c

ATOM 18831 CG LEU D 154 -9. 761 -22. ,330 -42. 347 1. 00 61. 68 D c

ATOM 18833 CDl LEU D 154 -8. 809 -22. ,210 -41. 166 1. 00 65. 30 D c

ATOM 18837 CD 2 LEU D 154 -8. 978 -22. .288 -43. 636 1. 00 61. 70 D c

ATOM 18841 C LEU D 154 -12. ,505 -24, .860 -41.247 1. 00 58. 16 D c

ATOM 18842 0 LEU D 154 -12. ,250 -26, ,067 -41. 409 1. 00 55. 49 D 0

ATOM 18844 N GLN D 155 -13. 741 -24. .352 -41.277 1. 00 54. 65 D N

ATOM 18845 CA GLN D 155 -14. 906 -25. ,214 -41. 415 1. 00 50. 14 D c

ATOM 18847 CB GLN D 155 -16. 046 -24. ,733 -40. 523 1. 00 51. 74 D c

ATOM 18850 CG GLN D 155 -15. 693 -24, ,547 -39. 048 1. 00 51. 82 D c

ATOM 18853 CD GLN D 155 -15. 400 -25. ,858 -38. 325 1. 00 50. 83 D c

ATOM 18854 OEl GLN D 155 -16. 174 -26. ,818 -38. 399 1. 00 41. 87 D 0

ATOM 18855 NE2 GLN D 155 -14. 285 -25. .891 -37. 601 1. 00 47. 16 D N

ATOM 18858 C GLN D 155 -15. ,355 -25, .251 -42. 868 1. 00 48. 57 D c

ATOM 18859 0 GLN D 155 -15. 130 -24, .309 -43. 629 1. 00 53. 52 D 0

ATOM 18861 N SER D 156 -15. 975 -26, .357 -43. 258 1. 00 48. 45 D N

ATOM 18862 CA SER D 156 -16. 676 -26, .422 -44. 531 1. 00 51. 38 D c

ATOM 18864 CB SER D 156 -15. 746 -26, .913 -45. 652 1. 00 58. 09 D c

ATOM 18867 OG SER D 156 -15. 795 -28. .326 -45. 783 1. 00 57. 14 D 0

ATOM 18869 C SER D 156 -17. 828 -27, .383 -44. 376 1. 00 48. 54 D c

ATOM 18870 0 SER D 156 -17. 717 -28. .367 -43. 634 1. 00 48. 71 D 0

ATOM 18872 N GLY D 157 -18. ,936 -27, .088 -45. 052 1. 00 47. 45 D N

ATOM 18873 CA GLY D 157 -20. ,062 -28, .011 -45. 103 1. 00 47. 24 D c

ATOM 18876 C GLY D 157 -21. ,076 -27, .909 -43. 984 1. 00 46. 48 D c

ATOM 18877 0 GLY D 157 -22. ,109 -28, ,564 -44. 067 1. 00 48. 81 D 0

ATOM 18879 N ASN D 158 -20. 796 -27, .094 -42. 963 1. 00 45. 16 D N

ATOM 18880 CA ASN D 158 -21. ,683 -26, .926 -41. 806 1. 00 46. 36 D c

ATOM 18882 CB ASN D 158 -20. 993 -27, .464 -40. 552 1. 00 44. 54 D c

ATOM 18885 CG ASN D 158 -19. 619 -26, .900 -40. 358 1. 00 46. 00 D c

ATOM 18886 ODl ASN D 158 -19. 200 -25, .973 -41. 062 1. 00 47. 38 D 0

ATOM 18887 ND2 ASN D 158 -18. ,886 -27, .467 -39. 405 1. 00 51. ,53 D N

ATOM 18890 C ASN D 158 -22. ,167 -25, .475 -41. 563 1. 00 46. 81 D c

ATOM 18891 0 ASN D 158 -22. ,442 -25, .071 -40. 423 1. 00 44. 23 D 0

ATOM 18893 N SER D 159 -22. ,270 -24, .700 -42. 643 1. 00 47. 57 D N

ATOM 18894 CA SER D 159 -22. ,762 -23, .331 -42. 566 1. 00 45. 03 D c

ATOM 18896 CB SER D 159 -21. 596 -22, .360 -42. 516 1. 00 48. 33 D c

ATOM 18899 OG SER D 159 -20. 827 -22, .446 -43. 700 1. 00 50. 56 D 0

ATOM 18901 C SER D 159 -23. 646 -23, .030 -43. 768 1. 00 45. 67 D c

ATOM 18902 0 SER D 159 -23. 559 -23, .712 -44. 792 1. 00 45. 41 D 0

ATOM 18904 N GLN D 160 -24. ,500 -22, .023 -43. 625 1. 00 43. 83 D N

ATOM 18905 CA GLN D 160 -25. ,405 -21, .587 -44. 681 1. 00 45. ,25 D C

ATOM 18907 CB GLN D 160 -26. 787 -22, .243 -44. 535 1. 00 47. ,55 D C

ATOM 18910 CG GLN D 160 -26. 920 -23, .577 -45. 234 1. 00 47. ,68 D C human fD_Fab

ATOM 18913 CD GLN D 160 -28. ,257 -24. 247 -45. 008 1. 00 48. 64 D C

ATOM 18914 OEl GLN D 160 -28. 668 -24. 481 -43. 869 1. 00 52. 49 D 0

ATOM 18915 NE2 GLN D 160 -28. ,931 -24. 593 -46. 096 1. 00 51.36 D N

ATOM 18918 C GLN D 160 -25. ,550 -20. 088 -44. ,548 1. 00 43. ,66 D C

ATOM 18919 O GLN D 160 -25. ,561 -19. 576 -43. ,432 1. 00 43. ,63 D 0

ATOM 18921 N GLU D 161 -25. ,669 -19. 407 -45. ,688 1. 00 45. 29 D N

ATOM 18922 CA GLU D 161 -25. ,770 -17. 957 -45. 755 1. 00 47. 10 D C

ATOM 18924 CB GLU D 161 -24. ,738 -17. 393 -46. 714 1. 00 48. 86 D C

ATOM 18927 CG GLU D 161 -23. ,327 -17. 548 -46. 258 1. 00 57. 49 D c

ATOM 18930 CD GLU D 161 -22. ,361 -16. 773 -47. 124 1. 00 60. 18 D c

ATOM 18931 OEl GLU D 161 -22. ,771 -16.353 -48. 229 1. 00 69. 35 D 0

ATOM 18932 OE2 GLU D 161 -21. ,196 -16. 581 -46. 704 1. 00 68. 61 D 0

ATOM 18933 C GLU D 161 -27. ,109 -17. 539 -46. 297 1. 00 46. ,24 D c

ATOM 18934 O GLU D 161 -27. 756 -18. 301 -47. ,024 1. 00 43. 08 D 0

ATOM 18936 N SER D 162 -27. 490 -16. 303 -45. ,973 1. 00 45. 28 D N

ATOM 18937 CA SER D 162 -28. 727 -15. 716 -46. 451 1. 00 44. 97 D c

ATOM 18939 CB SER D 162 -29. ,885 -16. 103 -45. 532 1. 00 47. 99 D c

ATOM 18942 OG SER D 162 -31. 080 -15. 486 -45. 933 1. 00 46. 17 D 0

ATOM 18944 C SER D 162 -28. 540 -14. 214 -46. 503 1. 00 43. 72 D c

ATOM 18945 O SER D 162 -28. ,093 -13. 621 -45. 532 1. 00 46. 06 D 0

ATOM 18947 N VAL D 163 -28. ,868 -13. 618 -47. ,647 1. 00 43. 09 D N

ATOM 18948 CA VAL D 163 -28. ,624 -12. 206 -47. ,902 1. 00 41.80 D C

ATOM 18950 CB VAL D 163 -27. ,732 -12. 023 -49. ,160 1. 00 37. 55 D C

ATOM 18952 CGI VAL D 163 -27. ,075 -10. 676 -49. ,157 1. 00 33. 72 D c

ATOM 18956 CG2 VAL D 163 -26. ,679 -13. 097 -49. 230 1. 00 45. 17 D c

ATOM 18960 C VAL D 163 -29. 962 -11. 506 -48. 101 1. 00 42. 11 D c

ATOM 18961 O VAL D 163 -30. ,854 -12. 045 -48. 745 1. 00 44. 53 D 0

ATOM 18963 N THR D 164 -30. 110 -10. 313 -47. 539 1. 00 44. 66 D N

ATOM 18964 CA THR D 164 -31. 319 -9. 523 -47. 759 1. 00 44. 74 D c

ATOM 18966 CB THR D 164 -31. ,414 -8. 383 -46. ,757 1. 00 42. ,95 D c

ATOM 18968 OGl THR D 164 -30. 129 -7. 751 -46. 652 1. 00 44. 32 D 0

ATOM 18970 CG2 THR D 164 -31. ,854 -8. 891 -45. 406 1. 00 39. 07 D c

ATOM 18974 C THR D 164 -31. ,303 -8. 908 -49. ,148 1. 00 47. 82 D c

ATOM 18975 O THR D 164 -30. ,303 -8. 968 -49. 866 1. 00 50. 83 D 0

ATOM 18977 N GLU D 165 -32. ,424 -8. 309 -49. 521 1. 00 52. 62 D N

ATOM 18978 CA GLU D 165 -32. ,495 -7. 544 -50. 749 1. 00 51. 62 D c

ATOM 18980 CB GLU D 165 -33. ,931 -7. 557 -51. 291 1. 00 55. 16 D c

ATOM 18983 CG GLU D 165 -34. ,086 -7. 029 -52. ,717 1. 00 61. 89 D c

ATOM 18986 CD GLU D 165 -33. ,172 -7. 708 -53. ,740 1. 00 65. ,51 D c

ATOM 18987 OEl GLU D 165 -33. ,434 -8. 897 -54. ,066 1. 00 62. ,49 D 0

ATOM 18988 OE2 GLU D 165 -32. ,212 -7. 032 -54. ,210 1. 00 61.35 D 0

ATOM 18989 C GLU D 165 -31.971 -6. 131 -50. ,443 1. 00 50. 24 D c

ATOM 18990 O GLU D 165 -31. ,899 -5. 724 -49. ,282 1. 00 53. 20 D 0

ATOM 18992 N GLN D 166 -31.578 -5. 407 -51. ,482 1. 00 44. 97 D N

ATOM 18993 CA GLN D 166 -31. ,039 -4. 067 -51. ,324 1. 00 45. 52 D c

ATOM 18995 CB GLN D 166 -30. ,729 -3. 494 -52. 711 1. 00 43. 59 D c

ATOM 18998 CG GLN D 166 -29. ,685 -2. ,429 -52. ,737 1. ,00 42. ,42 D c

ATOM 19001 CD GLN D 166 -29. ,188 -2. ,129 -54. ,146 1. 00 41. ,69 D c

ATOM 19002 OEl GLN D 166 -29. 758 -2. 592 -55. ,134 1. 00 46. 08 D 0

ATOM 19003 NE2 GLN D 166 -28. 118 -1. ,349 -54. 239 1. 00 33. 09 D N

ATOM 19006 C GLN D 166 -32. 020 -3. ,172 -50. ,538 1. 00 48. ,21 D c

ATOM 19007 O GLN D 166 -33. 226 -3. 161 -50. ,811 1. 00 48. 92 D 0

ATOM 19009 N ASP D 167 -31. 499 -2. 459 -49. ,542 1. 00 48. 06 D N

ATOM 19010 CA ASP D 167 -32. ,321 -1. 640 -48. ,672 1. 00 46. 44 D c

ATOM 19012 CB ASP D 167 -31. ,506 -1. ,112 -47. ,491 1. ,00 45. 03 D c

ATOM 19015 CG ASP D 167 -32. ,360 -0. ,351 -46. ,489 1. ,00 41. ,70 D c

ATOM 19016 OD1 ASP D 167 -33. ,231 -0. ,966 -45. ,877 1. ,00 38. ,77 D 0

ATOM 19017 OD2 ASP D 167 -32. ,178 0. ,856 -46. ,317 1. ,00 41. ,59 D 0

ATOM 19018 C ASP D 167 -32. ,850 -0. ,476 -49. ,472 1. ,00 48. 61 D c

ATOM 19019 O ASP D 167 -32. ,112 0. ,105 -50. 259 1. 00 47. ,20 D 0

ATOM 19021 N SER D 168 -34. ,114 -0. ,126 -49. ,248 1. ,00 46. ,57 D N

ATOM 19022 CA SER D 168 -34. ,788 0. ,903 -50. ,029 1. 00 45. 39 D c

ATOM 19024 CB SER D 168 -36. ,308 0. 742 -49. ,875 1. 00 45. 86 D c

ATOM 19027 OG SER D 168 -36. ,725 0. ,947 -48. ,540 1. ,00 43. ,78 D 0

ATOM 19029 C SER D 168 -34. ,375 2. 328 -49. ,676 1. 00 44. ,06 D c

ATOM 19030 O SER D 168 -34. ,766 3. ,269 -50. ,361 1. ,00 45. ,43 D 0

ATOM 19032 N LYS D 169 -33. ,603 2. ,494 -48. ,606 1. 00 47. ,27 D N

ATOM 19033 CA LYS D 169 -33. ,156 3. 825 -48. 160 1. ,00 48. ,99 D c human fD_Fab

ATOM 19035 CB LYS D 169 -33. 468 4. 017 -46. , 669 1.00 52. 68 D C

ATOM 19038 CG LYS D 169 -34. 875 3. 533 -46. , 296 1.00 56. 30 D C

ATOM 19041 CD LYS D 169 -35. 392 4. 084 -44. , 965 1.00 57. 42 D C

ATOM 19044 CE LYS D 169 -36. 838 3. 600 -44. , 695 1.00 57. ,96 D C

ATOM 19047 NZ LYS D 169 -37. 266 3. 771 -43. 276 1.00 57. , 53 D N

ATOM 19051 C LYS D 169 -31. 675 4. 035 -48. 424 1.00 43. , 84 D C

ATOM 19052 0 LYS D 169 -31. 307 5. 016 -49. 041 1.00 45. , 37 D 0

ATOM 19054 N ASP D 170 -30. 847 3. 085 -47. 987 1.00 43. 87 D N

ATOM 19055 CA ASP D 170 -29. 392 3. 189 -48. , 052 1.00 44. 14 D C

ATOM 19057 CB ASP D 170 -28. 793 2 . 822 -46. 684 1.00 45. 09 D C

ATOM 19060 CG ASP D 170 -29. 051 1. 379 -46. , 296 1.00 48. 68 D c

ATOM 19061 ODl ASP D 170 -28. 824 0. 486 -47. 125 1.00 46. , 33 D 0

ATOM 19062 OD2 ASP D 170 -29. 471 1. 121 -45. , 150 1.00 58. 82 D 0

ATOM 19063 C ASP D 170 -28. 746 2 . 317 -49. , 142 1.00 41. , 63 D c

ATOM 19064 0 ASP D 170 -27. 532 2 . 388 -49. , 345 1.00 41.81 D 0

ATOM 19066 N SER D 171 -29. 547 1. 476 -49. , 799 1.00 37. 08 D N

ATOM 19067 CA SER D 171 -29. 110 0. 661 -50. 923 1.00 38. 49 D c

ATOM 19069 CB SER D 171 -28. 713 1. 550 -52. , 118 1.00 41. 96 D c

ATOM 19072 OG SER D 171 -29. 800 2. 386 -52. , 535 1.00 41. , 72 D 0

ATOM 19074 C SER D 171 -28. 015 -0. 368 -50. , 586 1.00 39. 67 D c

ATOM 19075 0 SER D 171 -27. 280 -0. 798 -51. ,454 1.00 41. , 27 D 0

ATOM 19077 N THR D 172 -27. 949 -0. 796 -49. , 329 1.00 43. 49 D N

ATOM 19078 CA THR D 172 -26. 983 -1. 801 -48. , 899 1.00 39. 51 D c

ATOM 19080 CB THR D 172 -26. 346 -1. 462 -47. , 544 1.00 36. 90 D c

ATOM 19082 OGl THR D 172 -27. 352 -1. 474 -46. , 538 1.00 34. 25 D 0

ATOM 19084 CG2 THR D 172 -25. 635 -0. 104 -47. , 587 1.00 36. 37 D c

ATOM 19088 C THR D 172 -27. 616 -3. 173 -48. , 745 1.00 42. 91 D c

ATOM 19089 0 THR D 172 -28. 842 -3. 319 -48. , 733 1.00 42. 92 D 0

ATOM 19091 N TYR D 173 -26. 749 -4. 176 -48. , 608 1.00 42. ,47 D N

ATOM 19092 CA TYR D 173 -27. 154 -5. 523 -48. , 279 1.00 40. 63 D c

ATOM 19094 CB TYR D 173 -26. 463 -6. 519 -49. , 219 1.00 45. 28 D c

ATOM 19097 CG TYR D 173 -26. 762 -6. 308 -50. , 677 1.00 46. 09 D c

ATOM 19098 CDl TYR D 173 -27. 884 -6. 886 -51. , 268 1.00 45. 78 D c

ATOM 19100 CEl TYR D 173 -28. 178 -6. 684 -52. , 611 1.00 42. , 43 D c

ATOM 19102 cz TYR D 173 -27. 349 -5. 902 -53. , 374 1.00 46. , 77 D c

ATOM 19103 OH TYR D 173 -27. 629 -5. 701 -54. 720 1.00 49. ,44 D 0

ATOM 19105 CE2 TYR D 173 -26. 227 -5. 307 -52. 801 1.00 47. , 60 D c

ATOM 19107 CD 2 TYR D 173 -25. 940 -5. 519 -51. , 465 1.00 46. , 11 D c

ATOM 19109 C TYR D 173 -26. 767 -5. 855 -46. 834 1.00 42. ,48 D c

ATOM 19110 0 TYR D 173 -25. 891 -5. 215 -46. , 247 1.00 40. 82 D 0

ATOM 19112 N SER D 174 -27. 435 -6. 860 -46. , 274 1.00 39. , 24 D N

ATOM 19113 CA SER D 174 -27. 008 -7. 494 -45. , 040 1.00 36. , 55 D c

ATOM 19115 CB SER D 174 -27. 911 -7. 088 -43. , 909 1.00 36. , 85 D c

ATOM 19118 OG SER D 174 -27. 739 -5. 706 -43. , 734 1.00 37. 23 D 0

ATOM 19120 C SER D 174 -27. 023 -8. 981 -45. , 211 1.00 36. , 75 D c

ATOM 19121 0 SER D 174 -27. 721 -9. 486 -46. ,070 1.00 38. , 90 D 0

ATOM 19123 N LEU D 175 -26. 260 -9. 688 -44. , 382 1.00 39. ,45 D N

ATOM 19124 CA LEU D 175 -26. 051 -11. 124 -44. , 552 1.00 38. , 38 D C

ATOM 19126 CB LEU D 175 -24. 790 -11. 378 -45. , 365 1.00 40. , 84 D C

ATOM 19129 CG LEU D 175 -24. 334 -12. 818 -45. , 684 1.00 39. , 27 D c

ATOM 19131 CDl LEU D 175 -23. 705 -12. 877 -47. , 095 1.00 34. 02 D c

ATOM 19135 CD2 LEU D 175 -23. 381 -13. 357 -44. , 650 1.00 37. 01 D c

ATOM 19139 C LEU D 175 -25. 956 -11. 818 -43. , 206 1.00 42. , 57 D c

ATOM 19140 0 LEU D 175 -25. 276 -11. 309 -42. , 296 1.00 39. 33 D 0

ATOM 19142 N SER D 176 -26. 685 -12. 940 -43. , 059 1.00 42. 36 D N

ATOM 19143 CA SER D 176 -26. 478 -13. 826 -41. ,935 1.00 43. , 15 D c

ATOM 19145 CB SER D 176 -27. 792 -14. 208 -41. .222 1.00 44. , 21 D c

ATOM 19148 OG SER D 176 -28. 483 -15. 267 -41.852 1.00 51. , 80 D 0

ATOM 19150 C SER D 176 -25. 681 -15. 025 -42. , 436 1.00 45. , 20 D c

ATOM 19151 0 SER D 176 -25. 826 -15. 434 -43. , 590 1.00 49. ,07 D 0

ATOM 19153 N SER D 177 -24. 783 -15. 528 -41. 594 1.00 43. , 83 D N

ATOM 19154 CA SER D 177 -24. 155 -16. 835 -41. , 805 1.00 43. 20 D c

ATOM 19156 CB SER D 177 -22. 668 -16. 724 -42 , , 108 1.00 49. , 58 D c

ATOM 19159 OG SER D 177 -22. 091 -18. ,009 -42 , .109 1.00 43. , 92 D 0

ATOM 19161 C SER D 177 -24. 330 -17. 637 -40, .533 1.00 45. , 01 D c

ATOM 19162 0 SER D 177 -24. 032 -17. 147 -39. .440 1.00 41. , 84 D 0

ATOM 19164 N THR D 178 -24. 818 -18. 866 -40, , 677 1.00 41. , 98 D N

ATOM 19165 CA THR D 178 -25. 095 -19. 681 -39. , 537 1.00 41. ,42 D c human fD_Fab

ATOM 19167 CB THR D 178 -26.577 -19. ,980 -39. 439 1.00 45. 88 D C

ATOM 19169 OGl THR D 178 -27.288 -18. ,746 -39. 537 1.00 46. 34 D 0

ATOM 19171 CG2 THR D 178 -26.895 -20. ,624 -38. 099 1.00 47. 01 D C

ATOM 19175 C THR D 178 -24.278 -20. ,955 -39. 565 1.00 43. 03 D C

ATOM 19176 O THR D 178 -24.337 -21. 721 -40. 517 1.00 40. 97 D 0

ATOM 19178 N LEU D 179 -23.505 -21. 154 -38. 494 1.00 43. 97 D N

ATOM 19179 CA LEU D 179 -22.783 -22. 379 -38. 249 1.00 41. 84 D C

ATOM 19181 CB LEU D 179 -21.506 -22. 045 -37. 507 1.00 41. 87 D c

ATOM 19184 CG LEU D 179 -20.472 -23. ,166 -37. 313 1.00 42. 06 D c

ATOM 19186 CDl LEU D 179 -19.900 -23. ,571 -38. 681 1.00 38. 34 D c

ATOM 19190 CD 2 LEU D 179 -19.385 -22. ,730 -36. 339 1.00 36. 54 D c

ATOM 19194 C LEU D 179 -23.650 -23. ,352 -37. 404 1.00 45. 72 D c

ATOM 19195 O LEU D 179 -24.098 -23. ,006 -36. 309 1.00 42. 23 D 0

ATOM 19197 N THR D 180 -23.892 -24. ,559 -37. 922 1.00 48. 77 D N

ATOM 19198 CA THR D 180 -24.667 -25. ,552 -37. 212 1.00 51. 23 D c

ATOM 19200 CB THR D 180 -25.793 -26. ,159 -38. 099 1.00 54. 63 D c

ATOM 19202 OGl THR D 180 -26.665 -25. ,120 -38. 561 1.00 55. 90 D 0

ATOM 19204 CG2 THR D 180 -26.622 -27. ,177 -37. 302 1.00 52. 12 D c

ATOM 19208 C THR D 180 -23.750 -26. ,667 -36. 685 1.00 52. 64 D c

ATOM 19209 O THR D 180 -23.081 -27. ,375 -37. 462 1.00 52. 84 D 0

ATOM 19211 N LEU D 181 -23.735 -26. ,806 -35. 357 1.00 54. 70 D M

ATOM 19212 CA LEU D 181 -22.968 -27. ,841 -34. 661 1.00 55. 04 D c

ATOM 19214 CB LEU D 181 -21.908 -27. ,198 -33. 773 1.00 50. 24 D c

ATOM 19217 CG LEU D 181 -20.877 -26. ,296 -34. 438 1.00 51. 53 D c

ATOM 19219 CDl LEU D 181 -20.131 -25. ,502 -33. 399 1.00 47. 98 D c

ATOM 19223 CD2 LEU D 181 -19.902 -27. ,123 -35. 296 1.00 55. 54 D c

ATOM 19227 C LEU D 181 -23.879 -28. ,655 -33. 760 1.00 56. 22 D c

ATOM 19228 O LEU D 181 -24.949 -28. ,196 -33. 358 1.00 58. 12 D 0

ATOM 19230 N SER D 182 -23.440 -29. ,857 -33. 413 1.00 58. 83 D N

ATOM 19231 CA SER D 182 -24.051 -30. ,591 -32. 304 1.00 58. 51 D c

ATOM 19233 CB SER D 182 -23.544 -32. ,035 -32. 261 1.00 58. 38 D c

ATOM 19236 OG SER D 182 -22.207 -32. ,073 -31.801 1.00 63. 89 D 0

ATOM 19238 C SER D 182 -23.690 -29. 863 -31. 003 1.00 57. 35 D c

ATOM 19239 O SER D 182 -22.721 -29. ,120 -30. 958 1.00 56. 98 D 0

ATOM 19241 N LYS D 183 -24.475 -30. ,069 -29. 949 1.00 61. 01 D N

ATOM 19242 CA LYS D 183 -24.111 -29. ,553 -28. 624 1.00 61. 48 D c

ATOM 19244 CB LYS D 183 -25.228 -29. 793 -27. 607 1.00 65. 10 D c

ATOM 19247 CG LYS D 183 -24.825 -29. 606 -26. 140 1.00 67. 42 D c

ATOM 19250 CD LYS D 183 -26.059 -29. ,425 -25. 227 1.00 67. 58 D c

ATOM 19253 CE LYS D 183 -25.692 -29. 356 -23. 727 1.00 69. 53 D c

ATOM 19256 NZ LYS D 183 -26.881 -29. ,065 -22. 843 1.00 69. 30 D N

ATOM 19260 C LYS D 183 -22.808 -30. ,208 -28. 183 1.00 60. 89 D C

ATOM 19261 O LYS D 183 -21.933 -29. ,543 -27. 621 1.00 61. 39 D 0

ATOM 19263 N ALA D 184 -22.678 -31. ,504 -28. 472 1.00 63. ,13 D N

ATOM 19264 CA ALA D 184 -21.460 -32. ,267 -28. 194 1.00 62. 04 D C

ATOM 19266 CB ALA D 184 -21.574 -33. ,677 -28. 778 1.00 62. ,03 D c

ATOM 19270 C ALA D 184 -20.223 -31.558 -28. 737 1.00 61.41 D c

ATOM 19271 O ALA D 184 -19.305 -31. ,249 -27. 980 1.00 62. 14 D 0

ATOM 19273 N ASP D 185 -20.209 -31.292 -30. 044 1.00 64. ,21 D N

ATOM 19274 CA ASP D 185 -19.057 -30. ,635 -30. 689 1.00 60. ,74 D c

ATOM 19276 CB ASP D 185 -19.160 -30. ,678 -32. 223 1.00 65. ,79 D c

ATOM 19279 CG ASP D 185 -18.690 -31. ,995 -32. 814 1.00 70. ,34 D c

ATOM 19280 ODl ASP D 185 -17.958 -32. ,763 -32. 141 1.00 73. ,63 D 0

ATOM 19281 OD2 ASP D 185 -19.051 -32. ,253 -33. 981 1.00 73. ,20 D 0

ATOM 19282 C ASP D 185 -18.887 -29. ,191 -30. 229 1.00 56. 56 D c

ATOM 19283 O ASP D 185 -17.763 -28. ,735 -30. ,015 1.00 58. ,77 D 0

ATOM 19285 N TYR D 186 -19.999 -28. ,474 -30. 080 1.00 56. ,43 D N

ATOM 19286 CA TYR D 186 -19.958 -27. ,094 -29. ,626 1.00 55. ,77 D c

ATOM 19288 CB TYR D 186 -21.369 -26. ,474 -29. 533 1.00 51. 16 D c

ATOM 19291 CG TYR D 186 -21.315 -25. ,041 -29. 013 1.00 49. 78 D c

ATOM 19292 CDl TYR D 186 -20.622 -24. ,054 -29. 717 1.00 48. ,42 D c

ATOM 19294 CEl TYR D 186 -20.523 -22. ,762 -29. 237 1.00 46. 95 D c

ATOM 19296 CZ TYR D 186 -21.122 -22. ,444 -28. 037 1.00 47. 68 D c

ATOM 19297 OH TYR D 186 -21.033 -21. ,170 -27. 550 1.00 49. ,73 D 0

ATOM 19299 CE2 TYR D 186 -21.807 -23. .395 -27. ,316 1.00 48. ,58 D c

ATOM 19301 CD2 TYR D 186 -21.894 -24, ,695 -27. ,805 1.00 46. ,07 D c

ATOM 19303 C TYR D 186 -19.254 -26. .977 -28. ,277 1.00 55. ,56 D c

ATOM 19304 O TYR D 186 -18.361 -26. ,158 -28. 115 1.00 52. ,55 D 0 human fD_Fab

ATOM 19306 N GLU D 187 -19. 656 -27. 799 -27. 311 1. 00 61. 89 D N

ATOM 19307 CA GLU D 187 -19. 007 -27. 790 -25. 987 1. 00 63. 34 D C

ATOM 19309 CB GLU D 187 -19. 948 -28. ,318 -24. ,907 1. 00 68. 82 D C

ATOM 19312 CG GLU D 187 -20. 768 -27. ,198 -24. ,281 1. 00 72. 70 D c

ATOM 19315 CD GLU D 187 -22. 193 -27. ,602 -24. ,030 1. 00 78. 61 D c

ATOM 19316 OEl GLU D 187 -22. 442 -28. 829 -23. ,911 1. 00 83. 31 D 0

ATOM 19317 OE2 GLU D 187 -23. 054 -26. ,691 -23. 953 1. 00 76. 05 D 0

ATOM 19318 C GLU D 187 -17. 640 -28. ,490 -25. 937 1. 00 62. 94 D c

ATOM 19319 O GLU D 187 -16. 984 -28. 470 -24. 912 1. 00 63. 10 D 0

ATOM 19321 N LYS D 188 -17. 209 -29. 076 -27. 048 1. 00 64. 07 D N

ATOM 19322 CA LYS D 188 -15. 875 -29. 642 -27. 154 1. 00 64. 06 D c

ATOM 19324 CB LYS D 188 -15. 862 -30. ,754 -28. ,199 1. 00 67. 37 D c

ATOM 19327 CG LYS D 188 -15. 025 -31. ,960 -27. ,799 1. 00 73. 55 D c

ATOM 19330 CD LYS D 188 -15. 502 -33. 247 -28. ,481 1. 00 73. 15 D c

ATOM 19333 CE LYS D 188 -16. 985 -33. 524 -28. ,210 1. 00 74. 59 D c

ATOM 19336 NZ LYS D 188 -17. 315 -34. ,970 -28. 317 1. 00 76. 62 D N

ATOM 19340 C LYS D 188 -14. 837 -28. ,572 -27. 520 1. 00 64. 54 D c

ATOM 19341 0 LYS D 188 -13. 640 -28. 767 -27. 286 1. 00 68. 25 D 0

ATOM 19343 N HIS D 189 -15. 275 -27. 451 -28. 097 1. 00 59. 62 D N

ATOM 19344 CA HIS D 189 -14. 341 -26. 406 -28. 535 1. 00 58. 05 D c

ATOM 19346 CB HIS D 189 -14. 402 -26. ,290 -30. ,044 1. 00 53. 46 D c

ATOM 19349 CG HIS D 189 -14. 067 -27. ,571 -30. ,727 1. 00 52. 15 D c

ATOM 19350 NDl HIS D 189 -15. 000 -28. ,564 -30. 937 1. 00 52. 24 D N

ATOM 19352 CEl HIS D 189 -14. 420 -29. ,590 -31. 529 1. 00 52. 12 D c

ATOM 19354 NE2 HIS D 189 -13. 142 -29. 303 -31. 695 1. 00 51. 57 D N

ATOM 19356 CD2 HIS D 189 -12. 895 -28. 051 -31. 191 1. 00 49. 40 D c

ATOM 19358 C HIS D 189 -14. 546 -25. 056 -27. 857 1. 00 55. 21 D c

ATOM 19359 O HIS D 189 -15. 591 -24. 795 -27. 277 1. 00 50. 76 D 0

ATOM 19361 N LYS D 190 -13. 518 -24. ,211 -27. 934 1. 00 60. 45 D N

ATOM 19362 CA LYS D 190 -13. 495 -22. ,932 -27. ,215 1. 00 61. 67 D c

ATOM 19364 CB LYS D 190 -12. 189 -22. ,765 -26. ,408 1. 00 64. 07 D c

ATOM 19367 CG LYS D 190 -11. 706 -21. 296 -26. ,274 1. 00 69. 50 D c

ATOM 19370 CD LYS D 190 -11. 177 -20. ,914 -24. 883 1. 00 72. 86 D c

ATOM 19373 CE LYS D 190 -9. 648 -21. ,042 -24. ,768 1. 00 75. 88 D c

ATOM 19376 NZ LYS D 190 -9. 118 -20. ,196 -23. 649 1. 00 75. 15 D N

ATOM 19380 C LYS D 190 -13. 704 -21. ,723 -28. ,138 1. 00 60. 27 D c

ATOM 19381 O LYS D 190 -14. 545 -20. 870 -27. 852 1. 00 61. 32 D 0

ATOM 19383 N VAL D 191 -12. 928 -21. ,630 -29. ,215 1. 00 57. 66 D N

ATOM 19384 CA VAL D 191 -12. 891 -20. ,412 -30. ,023 1. 00 56. 33 D c

ATOM 19386 CB VAL D 191 -11. 450 -20. ,009 -30. ,404 1. 00 54. 22 D c

ATOM 19388 CGl VAL D 191 -11. 485 -18. ,812 -31.380 1. 00 47. 75 D c

ATOM 19392 CG2 VAL D 191 -10. 636 -19. ,698 -29. ,148 1. 00 51. 32 D c

ATOM 19396 C VAL D 191 -13. 711 -20. ,526 -31. ,311 1. 00 54. 40 D c

ATOM 19397 O VAL D 191 -13. 388 -21. ,324 -32. ,207 1. 00 52. 32 D 0

ATOM 19399 N TYR D 192 -14. 745 -19. ,694 -31. ,407 1. 00 53. 05 D N

ATOM 19400 CA TYR D 192 -15. 594 -19. ,654 -32. ,594 1. 00 52. 75 D c

ATOM 19402 CB TYR D 192 -17. ,043 -19. ,922 -32. ,216 1. 00 54. 32 D c

ATOM 19405 CG TYR D 192 -17. 186 -21. ,276 -31. ,573 1. 00 54. ,11 D c

ATOM 19406 CDl TYR D 192 -17. 493 -22. ,395 -32. ,331 1. 00 52. 99 D c

ATOM 19408 CEl TYR D 192 -17. 603 -23. ,635 -31. ,751 1. 00 55. 22 D c

ATOM 19410 cz TYR D 192 -17. 391 -23. ,775 -30. ,391 1. 00 55. 66 D c

ATOM 19411 OH TYR D 192 -17. 510 -24. ,993 -29. ,804 1. 00 54. 61 D 0

ATOM 19413 CE2 TYR D 192 -17. 077 -22. ,684 -29. ,612 1. 00 56. 29 D c

ATOM 19415 CD2 TYR D 192 -16. 969 -21. ,439 -30. ,208 1. 00 54. 03 D c

ATOM 19417 C TYR D 192 -15. 432 -18. ,326 -33. ,315 1. 00 49. 73 D c

ATOM 19418 O TYR D 192 -15. 689 -17. ,266 -32. ,748 1. 00 47. ,81 D 0

ATOM 19420 N ALA D 193 -14. 997 -18. ,394 -34. ,568 1. 00 45. ,96 D N

ATOM 19421 CA ALA D 193 -14. 589 -17. ,197 -35. ,281 1. 00 49. ,40 D c

ATOM 19423 CB ALA D 193 -13. 052 -17. .118 -35. ,413 1. 00 50. 97 D c

ATOM 19427 C ALA D 193 -15. 221 -17. ,121 -36. ,651 1. 00 49. ,78 D c

ATOM 19428 O ALA D 193 -15. 239 -18. ,094 -37. ,426 1. 00 48. 86 D 0

ATOM 19430 N CYS D 194 -15. 675 -15. ,919 -36. ,954 1. 00 51. ,74 D N

ATOM 19431 CA CYS D 194 -16. 277 -15. 596 -38. ,217 1. 00 50. ,40 D C

ATOM 19433 CB CYS D 194 -17. 620 -14. ,922 -37. ,952 1. 00 54. ,71 D C

ATOM 19436 SG CYS D 194 -18. ,426 -14. ,498 -39. ,441 1. 00 60. 80 D s

ATOM 19438 C CYS D 194 -15. 339 -14. ,624 -38. ,921 1. 00 48. ,71 D c

ATOM 19439 O CYS D 194 -15. ,133 -13. ,512 -38. ,427 1. 00 47. ,09 D 0

ATOM 19441 N GLU D 195 -14. ,768 -15. ,045 -40. .052 1. 00 50. ,54 D N human fD_Fab

ATOM 19442 CA GLU D 195 -13. .896 -14. 184 -40. 855 1.00 50. ,72 D C

ATOM 19444 CB GLU D 195 -12, .606 -14. 915 -41. 225 1.00 54. ,74 D C

ATOM 19447 CG GLU D 195 -11. .581 -13. 961 -41. 879 1.00 54. 97 D C

ATOM 19450 CD GLU D 195 -10. ,309 -14. ,656 -42. 309 1.00 58. 81 D C

ATOM 19451 OEl GLU D 195 -10. ,402 -15. 701 -43. 000 1.00 59. 12 D 0

ATOM 19452 OE2 GLU D 195 -9, ,217 -14. 142 -41. 956 1.00 66. ,04 D 0

ATOM 19453 C GLU D 195 -14. ,587 -13. 686 -42. 133 1.00 48. ,21 D C

ATOM 19454 O GLU D 195 -15. ,112 -14. 486 -42. 907 1.00 48. 32 D 0

ATOM 19456 N VAL D 196 -14. ,550 -12. 373 -42. 349 1.00 49. ,51 D N

ATOM 19457 CA VAL D 196 -15. ,282 -11. 714 -43. 430 1.00 46. ,28 D c

ATOM 19459 CB VAL D 196 -16. ,185 -10. 626 -42. 838 1.00 44. ,79 D c

ATOM 19461 CGI VAL D 196 -16. ,833 -9. 780 -43. 951 1.00 43. 32 D c

ATOM 19465 CG2 VAL D 196 -17. ,219 -11. 254 -41.953 1.00 42. ,25 D c

ATOM 19469 C VAL D 196 -14. .371 -11. 045 -44. 456 1.00 46. ,06 D c

ATOM 19470 O VAL D 196 -13. ,551 -10. 208 -44. 097 1.00 47. ,08 D 0

ATOM 19472 N THR D 197 -14. ,540 -11. 387 -45. 737 1.00 47. ,54 D N

ATOM 19473 CA THR D 197 -13. ,825 -10. 692 -46. 831 1.00 47. ,09 D C

ATOM 19475 CB THR D 197 -13. ,047 -11. 692 -47. 759 1.00 52. ,80 D C

ATOM 19477 OGl THR D 197 -12. ,292 -12. 610 -46. 961 1.00 55. 00 D 0

ATOM 19479 CG2 THR D 197 -12. ,101 -10. 962 -48. 761 1.00 50. 59 D C

ATOM 19483 C THR D 197 -14, ,831 -9. 885 -47. 667 1.00 46. ,61 D C

ATOM 19484 O THR D 197 -15. ,842 -10. 419 -48. 135 1.00 45. ,51 D 0

ATOM 19486 N HIS D 198 -14. ,538 -8. 598 -47. 845 1.00 48. ,80 D N

ATOM 19487 CA HIS D 198 -15. ,352 -7. 689 -48. 631 1.00 48. ,47 D C

ATOM 19489 CB HIS D 198 -16. ,492 -7. 112 -47. 797 1.00 50. 23 D c

ATOM 19492 CG HIS D 198 -17. ,408 -6. 225 -48. 585 1.00 50. 82 D c

ATOM 19493 NDl HIS D 198 -17. ,199 -4. 870 -48. 715 1.00 53. 22 D N

ATOM 19495 CEl HIS D 198 -18. ,143 -4. 350 -49. 474 1.00 49. 60 D c

ATOM 19497 NE2 HIS D 198 -18. ,955 -5. 321 -49. 848 1.00 53. ,50 D N

ATOM 19499 CD2 HIS D 198 -18. ,519 -6. 504 -49. 306 1.00 47. 96 D C

ATOM 19501 C HIS D 198 -14. ,478 -6. 538 -49. 167 1.00 50. 55 D c

ATOM 19502 O HIS D 198 -13. 491 -6. 134 -48. 522 1.00 52. 51 D 0

ATOM 19504 N GLN D 199 -14. 864 -6. 009 -50. 332 1.00 50. 13 D N

ATOM 19505 CA GLN D 199 -14, ,137 -4. 931 -51. 001 1.00 49. 94 D c

ATOM 19507 CB GLN D 199 -14. ,821 -4. 566 -52. 346 1.00 54. ,46 D c

ATOM 19510 CG GLN D 199 -14. ,258 -3. 319 -53. 056 1.00 55. 35 D c

ATOM 19513 CD GLN D 199 -15. ,007 -2. 933 -54. 355 1.00 60. 27 D c

ATOM 19514 OEl GLN D 199 -15. 806 -3. 712 -54. 908 1.00 59. 18 D 0

ATOM 19515 NE2 GLN D 199 -14. ,738 -1. 709 -54. 844 1.00 57. 47 D N

ATOM 19518 C GLN D 199 -13. ,958 -3. 680 -50. 124 1.00 49. 66 D c

ATOM 19519 O GLN D 199 -12. ,972 -2. 963 -50. 278 1.00 51. ,51 D 0

ATOM 19521 N GLY D 200 -14. ,899 -3. 400 -49. 226 1.00 46. ,97 D N

ATOM 19522 CA GLY D 200 -14. ,801 -2. 233 -48. 356 1.00 46. 16 D c

ATOM 19525 C GLY D 200 -13. ,935 -2. 465 -47. 128 1.00 47. 56 D c

ATOM 19526 O GLY D 200 -13. ,790 -1. 562 -46. 310 1.00 46. 75 D 0

ATOM 19528 N LEU D 201 -13. ,397 -3. 681 -46. 978 1.00 48. 89 D N

ATOM 19529 CA LEU D 201 -12. ,474 -4. 035 -45. 882 1.00 51. ,37 D c

ATOM 19531 CB LEU D 201 -12. ,948 -5. 308 -45. 151 1.00 52. ,74 D c

ATOM 19534 CG LEU D 201 -14. ,224 -5. 180 -44. 292 1.00 51. ,46 D c

ATOM 19536 CDl LEU D 201 -14. ,687 -6. 539 -43. 757 1.00 44. 16 D c

ATOM 19540 CD2 LEU D 201 -14. ,015 -4. 184 -43. 159 1.00 50. 44 D c

ATOM 19544 C LEU D 201 -11. ,082 -4. 263 -46.460 1.00 51. 58 D c

ATOM 19545 0 LEU D 201 -10. ,911 -5. 112 -47. 334 1.00 48. 63 D 0

ATOM 19547 N SER D 202 -10. ,093 -3. 508 -45. 972 1.00 54. ,97 D N

ATOM 19548 CA SER D 202 -8. ,736 -3. 508 -46. 565 1.00 57. ,47 D c

ATOM 19550 CB SER D 202 -7, ,846 -2. ,460 -45. 873 1.00 67. 97 D c

ATOM 19553 OG SER D 202 -7. ,659 -2. ,758 -44. 492 1.00 73. 57 D 0

ATOM 19555 C SER D 202 -8. ,069 -4. 903 -46. 517 1.00 60. 46 D c

ATOM 19556 0 SER D 202 -7. ,465 -5. 361 -47. 506 1.00 58. 98 D 0

ATOM 19558 N SER D 203 -8. .190 -5. ,558 -45. 356 1.00 60. ,48 D N

ATOM 19559 CA SER D 203 -7. ,933 -7. ,000 -45. 197 1.00 58. 31 D c

ATOM 19561 CB SER D 203 -6, ,620 -7. ,211 -44. 425 1.00 59. ,08 D c

ATOM 19564 OG SER D 203 -6. ,649 -6. ,493 -43. 194 1.00 59. 30 D 0

ATOM 19566 C SER D 203 -9. ,106 -7. 667 -44. 436 1.00 58. 84 D c

ATOM 19567 0 SER D 203 -9. ,877 -6. 971 -43. 741 1.00 57. 58 D 0

ATOM 19569 N PRO D 204 -9. ,242 -9. ,012 -44. 554 1.00 57. 78 D N

ATOM 19570 CA PRO D 204 -10. ,343 -9. ,750 -43. 906 1.00 58. ,14 D c

ATOM 19572 CB PRO D 204 -9. ,985 -11. ,221 -44. 164 1.00 59. ,58 D c human fD_Fab

ATOM 19575 CG PRO D 204 -9. 178 -11. ,188 -45. ,455 1. 00 59. 78 D C

ATOM 19578 CD PRO D 204 -8. 377 -9. ,911 -45. ,354 1. 00 60. 01 D C

ATOM 19581 C PRO D 204 -10. 452 -9. ,504 -42. ,413 1. 00 59. 16 D C

ATOM 19582 O P O D 204 -9. 447 -9. ,568 -41. .723 1. 00 61. 55 D 0

ATOM 19583 N VAL D 205 -11. 665 -9. ,221 -41, .943 1. 00 58. ,15 D N

ATOM 19584 CA VAL D 205 -11. 944 -8. ,979 -40. .541 1. 00 55. ,87 D C

ATOM 19586 CB VAL D 205 -12. 922 -7. ,798 -40. .390 1. 00 60. ,14 D C

ATOM 19588 CGI VAL D 205 -13. 794 -7. ,948 -39. ,140 1. 00 61. 89 D C

ATOM 19592 CG2 VAL D 205 -12. 140 -6. 486 -40. ,373 1. 00 62. 00 D c

ATOM 19596 C VAL D 205 -12. 519 -10. ,239 -39. ,891 1. 00 55. 73 D c

ATOM 19597 O VAL D 205 -13. 385 -10. ,915 -40. ,458 1. 00 58. 30 D 0

ATOM 19599 N THR D 206 -12. 035 -10. ,549 -38. ,693 1. 00 54. 64 D N

ATOM 19600 CA THR D 206 -12. 464 -11. ,736 -37. ,938 1. 00 51. ,49 D c

ATOM 19602 CB THR D 206 -11. 238 -12. ,618 -37. ,557 1. 00 50. 61 D c

ATOM 19604 OGl THR D 206 -10. 604 -13. ,090 -38, ,758 1. 00 47. ,13 D 0

ATOM 19606 CG2 THR D 206 -11. 630 -13. ,805 -36. ,687 1. 00 50. 76 D c

ATOM 19610 C THR D 206 -13. 203 -11. ,274 -36. ,698 1. 00 48. 60 D c

ATOM 19611 O THR D 206 -12. 755 -10. 352 -36. ,023 1. 00 45. 98 D 0

ATOM 19613 N LYS D 207 -14. 359 -11. ,882 -36. ,436 1. 00 47. 76 D N

ATOM 19614 CA LYS D 207 -15. 152 -11.577 -35. ,256 1. 00 48. 01 D c

ATOM 19616 CB LYS D 207 -16. 513 -11. ,002 -35. ,661 1. 00 51. 33 D c

ATOM 19619 CG LYS D 207 -17. 347 -10. ,462 -34. ,522 1. 00 51. 83 D c

ATOM 19622 CD LYS D 207 -16. 876 -9. ,076 -34. ,113 1. 00 52. ,72 D c

ATOM 19625 CE LYS D 207 -17. 802 -8. ,462 -33. ,068 1. 00 54. 05 D c

ATOM 19628 NZ LYS D 207 -17. 323 -7. ,101 -32. ,683 1. 00 57. 41 D N

ATOM 19632 C LYS D 207 -15. 333 -12. 889 -34. ,523 1. 00 45. 79 D c

ATOM 19633 0 LYS D 207 -15. 768 -13. ,879 -35. ,130 1. 00 46. 67 D 0

ATOM 19635 N SER D 208 -15. 005 -12. ,920 -33. ,231 1. 00 46. 64 D N

ATOM 19636 CA SER D 208 -14. 984 -14. ,195 -32. ,514 1. 00 48. 10 D c

ATOM 19638 CB SER D 208 -13. 609 -14. ,875 -32. ,661 1. 00 56. ,01 D c

ATOM 19641 OG SER D 208 -12. 541 -13. ,974 -32. ,416 1. 00 61. 91 D 0

ATOM 19643 C SER D 208 -15. 335 -14. .068 -31.052 1. 00 48. 51 D c

ATOM 19644 O SER D 208 -15. 267 -12. ,998 -30. ,490 1. 00 52. ,43 D 0

ATOM 19646 N PHE D 209 -15. 723 -15. ,186 -30. ,454 1. 00 47. 14 D N

ATOM 19647 CA PHE D 209 -15. 889 -15. ,287 -29. ,009 1. 00 49. 69 D c

ATOM 19649 CB PHE D 209 -17. 374 -15. ,137 -28. ,608 1. 00 49. 29 D c

ATOM 19652 CG PHE D 209 -18. 229 -16. ,306 -29. ,012 1. 00 49. 29 D c

ATOM 19653 CDl PHE D 209 -18. 455 -17. ,358 -28. ,132 1. 00 50. 09 D c

ATOM 19655 CEl PHE D 209 -19. 221 -18. ,450 -28. ,497 1. 00 48. ,65 D c

ATOM 19657 CZ PHE D 209 -19. 762 -18. ,503 -29. ,765 1. 00 49. ,81 D c

ATOM 19659 CE2 PHE D 209 -19. 531 -17. ,460 -30. ,660 1. 00 47. ,39 D c

ATOM 19661 CD2 PHE D 209 -18. 767 -16. ,379 -30, ,285 1. 00 47. ,64 D c

ATOM 19663 C PHE D 209 -15. 304 -16. ,634 -28. ,528 1. 00 49. 46 D c

ATOM 19664 O PHE D 209 -15. 040 -17. ,549 -29. ,339 1. 00 46. 80 D 0

ATOM 19666 N ASN D 210 -15. 096 -16. ,725 -27, ,214 1. 00 51. 50 D N

ATOM 19667 CA ASN D 210 -14. 689 -17. .966 -26, ,542 1. 00 52. ,55 D c

ATOM 19669 CB ASN D 210 -13. 631 -17. ,643 -25, .499 1. 00 54. ,69 D c

ATOM 19672 CG ASN D 210 -12. 476 -16. .855 -26, .079 1. 00 56. ,61 D c

ATOM 19673 001 ASN D 210 -12. 250 -15. ,708 -25. .694 1. 00 57. ,27 D 0

ATOM 19674 ND2 ASN D 210 -11. 747 -17. ,461 -27. .030 1. 00 55. ,35 D N

ATOM 19677 C ASN D 210 -15. 892 -18. ,569 -25. ,858 1. 00 52. ,84 D C

ATOM 19678 0 ASN D 210 -16. 650 -17, ,835 -25. ,220 1. 00 50. ,87 D 0

ATOM 19680 N ARG D 211 -16. 094 -19. ,883 -25. ,990 1. 00 55. ,79 D N

ATOM 19681 CA ARG D 211 -17. 303 -20. ,500 -25. ,437 1. 00 58. ,69 D C

ATOM 19683 CB ARG D 211 -17. 393 -21, .994 -25, .733 1. 00 59. ,16 D c

ATOM 19686 CG ARG D 211 -18. 678 -22. .649 -25, .192 1. 00 58. ,13 D c

ATOM 19689 CD ARG D 211 -18. 682 -24. .150 -25, .410 1. 00 62. ,00 D c

ATOM 19692 NE ARG D 211 -17. 366 -24. ,758 -25, .174 1. 00 63. ,90 D N

ATOM 19694 CZ ARG D 211 -16. 816 -24. ,939 -23, .970 1. 00 67. ,08 D c

ATOM 19695 NHl ARG D 211 -17. 456 -24. ,582 -22. .855 1. 00 68. ,10 D N

ATOM 19698 NH2 ARG D 211 -15. 609 -25. ,494 -23. .878 1. 00 67. ,43 D N

ATOM 19701 C ARG D 211 -17. 349 -20. ,240 -23. ,942 1. 00 63. ,79 D C

ATOM 19702 0 ARG D 211 -16. 375 -20. ,464 -23. ,231 1. 00 61.46 D 0

ATOM 19704 N GLY D 212 -18. 518 -19, .817 -23, .486 1. 00 71. .65 D N

ATOM 19705 CA GLY D 212 -18. 648 -18, .962 -22, .319 1. 00 78. ,79 D C

ATOM 19708 C GLY D 212 -18. 749 -17. .551 -22, .895 1. 00 85. ,37 D C

ATOM 19709 0 GLY D 212 -19. 225 -17. .395 -24, .035 1. 00 89. ,68 D 0

ATOM 19711 N GLU D 213 -18. 316 -16. .540 -22, ,127 1. 00 87. ,45 D N human fD_Fab

ATOM 19712 CA GLU D 213 -18. 150 -15. , 141 -22. 599 1.00 88. 16 D C

ATOM 19714 CB GLU D 213 -16. 716 -14. 965 -23. 149 1.00 91. 22 D C

ATOM 19717 CG GLU D 213 -15. 653 -14. 665 -22. 056 1.00 92. 30 D c

ATOM 19720 CD GLU D 213 -14. 451 -15. 616 -22 . 083 1.00 92. 85 D c

ATOM 19721 OEl GLU D 213 -14. 650 -16. 830 -21. 845 1.00 92 . 53 D 0

ATOM 19722 OE2 GLU D 213 -13. 310 -15 . 146 -22. 323 1.00 92. 58 D 0

ATOM 19723 C GLU D 213 -19. 216 -14. , 555 -23. 576 1.00 89. 57 D c

ATOM 19724 O GLU D 213 -19. 976 -15. 264 -24. 254 1.00 89. 03 D 0

ATOM 19726 CL CL I 1 -54. 281 2. , 347 -59. 649 1.00 28. 91 I CL

ATOM 19727 CL CL I 2 -60. 942 -6. 901 -76. 219 1.00 54. 32 I CL

ATOM 19728 OWO WAT M 2 -4. 534 15. , 367 -0. 874 1.00 18. 14 M 0

ATOM 19731 OWO WAT M 3 -35. 291 23. 410 15. 442 1.00 24. 36 M 0

ATOM 19734 OWO WAT M 5 -34. 835 20. 706 14. 449 1.00 37. 92 M 0

ATOM 19737 OWO WAT M 6 -37. 927 -5 . 957 -75 . 491 1.00 25. 09 M 0

ATOM 19740 OWO WAT M 7 -21. 419 13 . 667 15 . 297 1.00 26. 88 M 0

ATOM 19743 OWO WAT M 8 20. 933 10. , 125 -36. 094 1.00 60. 69 M 0

ATOM 19746 owo WAT M 9 -47. 242 16. 589 9. 571 1.00 29. 36 M 0

ATOM 19749 OWO WAT M 10 -8. 589 28. 328 -20. 932 1.00 31. 04 M 0

ATOM 19752 owo WAT M 11 -46. 641 19. 023 20. 352 1.00 32. 44 M 0

ATOM 19755 owo WAT M 12 -4. 389 -5. 578 -8. 131 1.00 44. 36 M 0

ATOM 19758 owo WAT M 13 0. 866 14. 130 -18. 623 1.00 28. 76 M 0

ATOM 19761 OWO WAT M 14 -37. 893 25. 389 10. 078 1.00 26. 62 M 0

ATOM 19764 owo WAT M 15 -5 . 619 9. 736 -23. 476 1.00 25. 21 M 0

ATOM 19767 OWO WAT M 16 13. 732 21. , 195 -14. 902 1.00 28. 82 M 0

ATOM 19770 OWO WAT M 17 -44. 296 -3 . , 704 -54. 865 1.00 29. 21 M 0

ATOM 19773 OWO WAT M 18 -14. 549 -0. , 785 -10. 645 1.00 37. 70 M 0

ATOM 19776 OWO WAT M 19 -31. 890 0. , 950 -52. 804 1.00 28. 85 M 0

ATOM 19779 OWO WAT M 20 -15. 871 -4. 863 -14. 468 1.00 32. 37 M 0

ATOM 19782 owo WAT M 21 -54. 349 6. 249 -75. 001 1.00 69. 32 M 0

ATOM 19785 OWO WAT M 22 19. 532 15. , 123 -18. 661 1.00 32. 55 M 0

ATOM 19788 OWO WAT M 23 -41. 979 21. , 730 21. 556 1.00 24. 74 M 0

ATOM 19791 owo WAT M 24 17. 691 4. 228 -25. 982 1.00 27. 81 M 0

ATOM 19794 OWO WAT M 25 3. 179 13 . 377 -11. 091 1.00 27. 03 M 0

ATOM 19797 owo WAT M 26 -46. 147 20. , 934 16. 845 1.00 28. 42 M 0

ATOM 19800 OWO WAT M 27 -15. 678 5 . , 801 9. 334 1.00 28. 38 M 0

ATOM 19803 owo WAT M 28 -13. 049 2 . , 883 -2. 347 1.00 30. 71 M 0

ATOM 19806 OWO WAT M 29 -58. 291 -3. , 451 -59. 105 1.00 31. 01 M 0

ATOM 19809 owo WAT M 30 -10. 145 12 . , 874 -4. 134 1.00 28. 92 M 0

ATOM 19812 OWO WAT M 31 1. 253 -4. , 003 -21. 892 1.00 28. 95 M 0

ATOM 19815 owo WAT M 32 -46. 856 -23 . , 145 -47. 970 1.00 31. 09 M 0

ATOM 19818 OWO WAT M 33 -42 . 886 -12. , 950 -65. 674 1.00 26. 68 M 0

ATOM 19821 owo WAT M 34 -26. 938 22. , 308 1. 239 1.00 32. 81 M 0

ATOM 19824 OWO WAT M 35 -2. 912 13. ,067 -5. 572 1.00 29. 70 M 0

ATOM 19827 owo WAT M 36 -25. 572 15. , 823 15. 827 1.00 23. 30 M 0

ATOM 19830 OWO WAT M 37 -8. 622 11. , 066 3 . 938 1.00 40. 15 M 0

ATOM 19833 owo WAT M 38 -66. 032 -12. , 467 -70. 057 1.00 32. 73 M 0

ATOM 19836 OWO WAT M 39 -18. 436 -4. , 274 -26. 926 1.00 53. 02 M 0

ATOM 19839 owo WAT M 40 -62. 205 -17. , 350 -59. 542 1.00 38. 82 M 0

ATOM 19842 OWO WAT M 41 28. 338 -9. , 426 -23 . 257 1.00 49. 31 M 0

ATOM 19845 owo WAT M 42 -23. 683 14. , 344 -10. 354 1.00 29. 81 M 0

ATOM 19848 owo WAT M 43 -96. 515 15 . , 554 -68. 590 1.00 50. 30 M 0

ATOM 19851 OWO WAT M 45 -39. 914 9. , 181 -66. 831 1.00 41. 67 M 0

ATOM 19854 owo WAT M 46 -30. 479 17 , , 106 4. 341 1.00 35 . 52 M 0

ATOM 19857 OWO WAT M 47 -44. 523 30. , 045 10. 553 1.00 21. 74 M 0

ATOM 19860 owo WAT M 48 5. 418 16. , 323 -19. 178 1.00 37. , 34 M 0

ATOM 19863 owo WAT M 49 -37. 733 32. , 247 19. 311 1.00 30. , 00 M 0

ATOM 19866 OWO WAT M 50 -3. 912 -6. , 478 -15. 147 1.00 31. 90 M 0

ATOM 19869 owo WAT M 51 17. 063 14. , 294 -18. 650 1.00 34. 51 M 0

ATOM 19872 OWO WAT M 52 -18. 561 -23. , 844 -42 . 765 1.00 36. , 09 M 0

ATOM 19875 OWO WAT M 53 -21. 384 -18. 980 -44. 959 1.00 37. 55 M 0

ATOM 19878 OWO WAT M 54 18. 205 5 . , 329 -29. 791 1.00 30. 71 M 0

ATOM 19881 OWO WAT M 55 -10. 913 33 . , 164 -6. , 150 1.00 44. , 43 M 0

ATOM 19884 owo WAT M 56 -44. 584 18. .450 29. 220 1.00 27. , 90 M 0

ATOM 19887 OWO WAT M 57 -8. 568 9. , 631 -2. 324 1.00 29. , 45 M 0

ATOM 19890 OWO WAT M 58 -63 . 696 -6. , 318 -64. , 827 1.00 27. 62 M 0

ATOM 19893 owo WAT M 59 -10. 177 14. , 602 -2. , 180 1.00 43 . , 16 M 0

ATOM 19896 owo WAT M 60 -0. 830 -10. , 545 -28. , 927 1.00 40. , 02 M 0

ATOM 19899 OWO WAT M 61 -14. 397 -2. , 677 -30. 574 1.00 36. , 73 M 0 human fD_Fab

ATOM 19902 OWO WAT M 62 -1. 331 -8. 781 -11. ,506 1.00 32. 26 M 0

ATOM 19905 OWO WAT M 63 -79. 884 11.946 -80. ,761 1.00 75. 12 M 0

ATOM 19908 OWO WAT M 64 -16. 759 -7. 195 -51.786 1.00 45. 62 M 0

ATOM 19911 OWO WAT M 65 -56. 684 -2. 070 -62. ,018 1.00 29. ,52 M 0

ATOM 19914 OWO WAT M 66 -18. 811 6. ,119 18. ,486 1.00 56. ,61 M 0

ATOM 19917 owo WAT M 67 9. 110 3. 564 -22. ,730 1.00 33. ,55 M 0

ATOM 19920 OWO WAT M 68 -63. 429 -23. ,226 -65. ,669 1.00 43. ,76 M 0

ATOM 19923 OWO WAT M 69 -56. 578 -0. 932 -64. ,442 1.00 36. ,05 M 0

ATOM 19926 OWO WAT M 70 -37. 982 36. 318 3. ,832 1.00 36. ,56 M 0

ATOM 19929 OWO WAT M 71 -7. 767 -9. 832 -17. ,903 1.00 41. 40 M 0

ATOM 19932 OWO WAT M 72 -41. 822 16. 779 2. ,235 1.00 34. 20 M 0

ATOM 19935 OWO WAT M 73 34. 957 1. 883 -5. ,431 1.00 59. 18 M 0

ATOM 19938 OWO WAT M 74 -19. 863 11. 555 15. ,342 1.00 20. ,99 M 0

ATOM 19941 OWO WAT M 75 -61.723 -8. 822 -47. ,957 1.00 37. ,79 M 0

ATOM 19944 owo WAT M 76 -19. 812 1. 521 -20. ,578 1.00 39. ,15 M 0

ATOM 19947 OWO WAT M 77 -13. 329 -14. 539 -45. ,719 1.00 38. ,21 M 0

ATOM 19950 owo WAT M 78 -29. 035 5. 515 13. 853 1.00 39. ,19 M 0

ATOM 19953 OWO WAT M 79 -25. 238 -13. 014 -28. 178 1.00 43. ,61 M 0

ATOM 19956 OWO WAT M 80 7. 152 18. 842 -19. ,277 1.00 54. 53 M 0

ATOM 19959 OWO WAT M 81 -1. 108 10. 935 -6. ,362 1.00 31. 08 M 0

ATOM 19962 owo WAT M 82 20. 727 22. ,990 -30. ,224 1.00 35. ,25 M 0

ATOM 19965 OWO WAT M 83 -45. 673 17. 700 14. ,282 1.00 30. ,91 M 0

ATOM 19968 OWO WAT M 84 -17. 975 10. 870 13. ,517 1.00 27. ,57 M 0

ATOM 19971 OWO WAT M 85 -53. 019 -3. 827 -53. ,802 1.00 27. 84 M 0

ATOM 19974 owo WAT M 86 16. 236 12. 599 -16. ,079 1.00 38. 59 M 0

ATOM 19977 OWO WAT M 87 3. 302 -1. 686 -25. ,486 1.00 33. 60 M 0

ATOM 19980 owo WAT M 88 -51. 936 0. 920 -58. ,566 1.00 40. 28 M 0

ATOM 19983 OWO WAT M 89 -64. 404 -8. 835 -57. ,977 1.00 37. 99 M 0

ATOM 19986 OWO WAT M 90 18. 290 1. 661 -34. ,980 1.00 29. 35 M 0

ATOM 19989 OWO WAT M 91 17. 374 0. 930 -28. ,466 1.00 33. ,61 M 0

ATOM 19992 OWO WAT M 93 -33. 916 -3. 562 -45. ,793 1.00 44. 35 M 0

ATOM 19995 OWO WAT M 94 -16. 425 9. 234 14. ,820 1.00 44. 20 M 0

ATOM 19998 OWO WAT M 95 -19. 309 -6. 036 -31. ,256 1.00 39. 52 M 0

ATOM 20001 OWO WAT M 96 5. 823 26. 633 -26. ,108 1.00 45. ,15 M 0

ATOM 20004 OWO WAT M 97 -39. 869 14. 202 12. ,233 1.00 33. ,18 M 0

ATOM 20007 owo WAT M 98 -36. 397 9. 665 32. ,485 1.00 33. 58 M 0

ATOM 20010 OWO WAT M 99 -42. 535 -23. 924 -48. ,682 1.00 38. 72 M 0

ATOM 20013 OWO WAT M 100 8. 965 0. ,856 -20. ,335 1.00 40. ,02 M 0

ATOM 20016 OWO WAT M 101 -41.054 -17. ,255 -44. ,484 1.00 53. ,61 M 0

ATOM 20019 owo WAT M 102 -12. 031 13. ,731 -19. ,130 1.00 30. ,01 M 0

ATOM 20022 OWO WAT M 103 -14. 829 19. ,769 -5. ,945 1.00 30. ,31 M 0

ATOM 20025 OWO WAT M 104 -45. 195 18. 395 16. ,813 1.00 41.55 M 0

ATOM 20028 OWO WAT M 105 -26. 193 5. ,835 -56. ,398 1.00 35. ,25 M 0

ATOM 20031 owo WAT M 106 -19. 232 20. 545 17. ,504 1.00 51. ,18 M 0

ATOM 20034 OWO WAT M 107 1. 313 -1. 920 -15. ,907 1.00 35. ,52 M 0

ATOM 20037 owo WAT M 108 -37. 456 -0. 672 -52. .644 1.00 59. ,97 M 0

ATOM 20040 OWO WAT M 109 -43. 541 -17. ,665 -61.769 1.00 33. 98 M 0

ATOM 20043 owo WAT M 110 -49. 574 16. ,868 26. ,087 1.00 31. ,52 M 0

ATOM 20046 OWO WAT M 111 -23. 554 6. ,858 -10. ,383 1.00 35. ,63 M 0

ATOM 20049 OWO WAT M 112 -37. 975 -16. ,683 -46, ,818 1.00 32. ,08 M 0

ATOM 20052 OWO WAT M 113 -23. 932 7. ,112 -7. ,203 1.00 37. ,47 M 0

ATOM 20055 OWO WAT M 114 -14. 979 -7. ,848 -30. ,901 1.00 28. 92 M 0

ATOM 20058 owo WAT M 115 -28. 837 -3. ,769 -45. ,797 1.00 44. ,96 M 0

ATOM 20061 OWO WAT M 116 -50. 356 -28. ,925 -66. ,409 1.00 42. ,45 M 0

ATOM 20064 OWO WAT M 117 -28. 888 9. ,122 -66, .969 1.00 39. ,47 M 0

ATOM 20067 OWO WAT M 118 33. 501 7. ,357 -40. .098 1.00 45. ,31 M 0

ATOM 20070 OWO WAT M 119 -4. 425 22. ,757 -23, ,255 1.00 32. .08 M 0

ATOM 20073 owo WAT M 120 -3. 213 32. 620 -7, ,259 1.00 39. ,79 M 0

ATOM 20076 OWO WAT M 121 -18. 342 2. 158 12. ,409 1.00 49. ,51 M 0

ATOM 20079 OWO WAT M 122 -24. 124 17. 186 -7. ,029 1.00 33. ,90 M 0

ATOM 20082 OWO WAT M 123 -58. 994 -29. ,050 -61. ,007 1.00 37. 08 M 0

ATOM 20085 OWO WAT M 124 10. 030 19. ,817 -20. ,243 1.00 50. ,62 M 0

ATOM 20088 owo WAT M 125 -47. 255 -3. ,464 -53. ,069 1.00 41. 31 M 0

ATOM 20091 OWO WAT M 126 27. 250 22. ,243 -33, .328 1.00 35. 86 M 0

ATOM 20094 OWO WAT M 127 -16. 794 -8. ,250 -26, .920 1.00 40. ,45 M 0

ATOM 20097 owo WAT M 128 -30. 903 34. ,074 22, .462 1.00 45. ,34 M 0

ATOM 20100 OWO WAT M 129 -48. 251 28. ,786 26. ,131 1.00 42. ,83 M 0

ATOM 20103 OWO WAT M 130 -15. 026 -24. ,898 -20. .593 1.00 44. ,85 M 0 human fD_Fab

ATOM 20106 OWO WAT M 131 -48. 220 -13. 957 -68. ,169 1.00 28. 45 M O

ATOM 20109 OWO WAT M 132 -6. 097 -12. 095 -26. 261 1.00 34. 29 M 0

ATOM 20112 OWO WAT M 133 30. ,091 -0. 876 -25. ,288 1.00 46. ,76 M 0

ATOM 20115 OWO WAT M 134 -8. ,477 27. 597 -10. ,094 1.00 42. 55 M 0

ATOM 20118 OWO WAT M 135 -47. 229 -18. 234 -42. ,048 1.00 37. ,15 M 0

ATOM 20121 OWO WAT M 136 44. 196 -2. 873 -25. 182 1.00 65. 60 M 0

ATOM 20124 OWO WAT M 137 -54. 351 -0. 743 -69. ,427 1.00 33. 20 M 0

ATOM 20127 OWO WAT M 138 -56. 242 -5. 531 -51. ,516 1.00 29. 29 M 0

ATOM 20130 OWO WAT M 139 -11. 273 21. 269 20. 386 1.00 54. 11 M 0

ATOM 20133 OWO WAT M 140 -32. ,158 -17. 946 -43. ,434 1.00 44. 49 M 0

ATOM 20136 owo WAT M 141 -64. 018 -14. 853 -70. ,071 1.00 46. 21 M 0

ATOM 20139 OWO WAT M 142 -51. 145 -3. 152 -55. ,502 1.00 29. 83 M 0

ATOM 20142 OWO WAT M 143 -52. 231 -16. 329 -47. 452 1.00 35. 57 M 0

ATOM 20145 OWO WAT M 144 -77. 220 9. 950 -86. ,384 1.00 54. 03 M 0

ATOM 20148 OWO WAT M 145 21. 191 -5. 947 -8. 236 1.00 41. 30 M 0

ATOM 20151 OWO WAT M 146 20. 674 -7. 719 -37. 116 1.00 47. 56 M 0

ATOM 20154 OWO WAT M 147 18. 038 2. 707 -9. ,962 1.00 39. ,44 M 0

ATOM 20157 OWO WAT M 148 -40. 492 -13. 872 -43. ,073 1.00 41. 26 M 0

ATOM 20160 ow WAT M 149 -36. 101 -4. 809 -19. 665 1.00 44. 93 M 0

ATOM 20163 ow WAT M 150 0. 404 -5. 640 -9. 261 1.00 36. 59 M 0

ATOM 20166 ow WAT M 151 -47. 856 -6. 320 -50. 032 1.00 49. 64 M 0

ATOM 20169 ow WAT M 152 12. 364 2. 173 -15. ,663 1.00 40. 03 M 0

ATOM 20172 ow WAT M 153 -66. 525 0. 268 -57. 321 1.00 38. 51 M 0

ATOM 20175 ow WAT M 154 4. 562 -11. 140 -33. ,091 1.00 45. 53 M 0

ATOM 20178 ow WAT M 155 -42. 096 -5. 067 -37. ,148 1.00 43. 55 M 0

ATOM 20181 ow WAT M 156 -24. 551 3. 519 -15. ,184 1.00 43. 00 M 0

ATOM 20184 ow WAT M 157 13. 711 -3. 364 -12. 760 1.00 37. 73 M 0

ATOM 20187 ow WAT M 158 16. 368 16. 368 -30. 240 1.00 41. 16 M 0

ATOM 20190 ow WAT M 159 -47. 305 24. 586 4. 890 1.00 43. 93 M 0

ATOM 20193 OW WAT M 160 -1. 509 8. 828 -4. 973 1.00 26. 52 M 0

ATOM 20196 OW WAT M 161 -48. 560 17. 647 28. ,452 1.00 44. 73 M 0

ATOM 20199 ow WAT M 162 -62. 176 2. 313 -58. ,927 1.00 45. 21 M 0

ATOM 20202 ow WAT M 163 -25. 013 28. 118 6. ,717 1.00 46. 71 M 0

ATOM 20205 ow WAT M 164 19. 269 2. 302 -27. 360 1.00 24. 19 M 0

ATOM 20208 ow WAT M 165 -36. 375 18. 726 -4. ,934 1.00 58. 58 M 0

ATOM 20211 ow WAT M 166 -33. 696 -5. 260 -57. 400 1.00 34. 73 M 0

ATOM 20214 ow WAT M 167 -40. 529 -15. 181 -55. ,251 1.00 47. 19 M 0

ATOM 20217 ow WAT M 168 -9. 018 7. 126 4. ,815 1.00 26. ,55 M 0

ATOM 20220 ow WAT M 169 38. 278 6. 226 -34. ,703 1.00 35. 73 M 0

ATOM 20223 ow WAT M 170 19. 914 28. 518 -16. 239 1.00 35. 62 M 0

ATOM 20226 ow WAT M 171 0. 550 -2. 228 -13. ,264 1.00 37. 78 M 0

ATOM 20229 ow WAT M 172 -1. 792 7. 553 -28. ,851 1.00 43. 24 M 0

ATOM 20232 ow WAT M 173 -40. 052 1. 555 -50. ,693 1.00 43. 29 M 0

ATOM 20235 ow WAT M 174 -12. 187 11. 272 -23. ,326 1.00 42. ,77 M 0

ATOM 20238 ow WAT M 175 -23. 147 15. 469 -8. ,448 1.00 32. 11 M 0

ATOM 20241 ow WAT M 176 30. 243 26. 751 -27. ,375 1.00 44. ,75 M 0

ATOM 20244 ow WAT M 177 -33. 251 7. 129 -49. 061 1.00 34. 95 M 0

ATOM 20247 ow WAT M 178 32. 656 24. 012 -28. ,413 1.00 32. ,40 M 0

ATOM 20250 ow WAT M 179 -65. 605 -20. 485 -69. ,126 1.00 49. 49 M 0

ATOM 20253 ow WAT M 180 -40. 423 8. 167 8. ,134 1.00 51. 86 M 0

ATOM 20256 ow WAT M 181 -15. ,464 -11. ,444 -21. ,585 1.00 47. ,33 M 0

ATOM 20259 ow WAT M 182 2. 451 -2. 709 -11. ,420 1.00 43. ,83 M 0

ATOM 20262 ow WAT M 183 -25. 546 24. 110 -6. ,960 1.00 41. ,95 M 0

ATOM 20265 ow WAT M 184 -38. 504 31. 345 32. ,264 1.00 45. 43 M 0

ATOM 20268 ow WAT M 185 -39. 165 5. 129 1. ,925 1.00 37. ,64 M 0

ATOM 20271 ow WAT M 186 -24. 835 4. 490 34. ,437 1.00 48. ,71 M 0

ATOM 20274 ow WAT M 187 -42. 293 -24. 390 -58. ,050 1.00 41. 89 M 0

ATOM 20277 ow WAT M 188 -41. ,672 8. ,078 -71. ,207 1.00 44. ,48 M 0

ATOM 20280 ow WAT M 189 -40. 235 -10. ,130 -58. ,774 1.00 32. ,72 M 0

ATOM 20283 ow WAT M 190 -22. 298 -0. 407 -15. ,509 1.00 44. 26 M 0

ATOM 20286 ow WAT M 191 -36. 695 7. 918 -2. ,290 1.00 41. ,96 M 0

ATOM 20289 ow WAT M 192 -15. 993 -28. ,731 -40. ,944 1.00 42. ,17 M 0

ATOM 20292 ow WAT M 193 -60. 691 -15. 702 -47. ,899 1.00 48. ,79 M 0

ATOM 20295 ow WAT M 194 -7. 677 -2. 532 -33. ,616 1.00 38. ,58 M 0

ATOM 20298 ow WAT M 195 -50. 530 10. ,021 -67. ,323 1.00 39. ,55 M 0

ATOM 20301 ow WAT M 196 -19. 058 -17. ,104 -48. ,455 1.00 39. ,05 M 0

ATOM 20304 ow WAT M 197 -67. 887 -19. ,888 -63. ,511 1.00 45. ,06 M 0

ATOM 20307 ow WAT M 198 -10. 034 -8. ,599 -37. ,501 1.00 37. ,71 M 0 human fD_Fab

ATOM 20310 OW WAT M 199 -60. 619 -10. 534 -75. 220 1.00 41. ,76 M O

ATOM 20313 OW WAT M 200 -57. ,798 -26. 874 -49. 390 1.00 52. ,99 M O

ATOM 20316 OW WAT M 201 -48. ,232 -21. 404 -30. 457 1.00 43. ,45 M O

ATOM 20319 OW WAT M 202 -49. ,299 10. 476 24. 480 1.00 39. ,95 M 0

ATOM 20322 OW WAT M 203 23. ,076 30. 637 -22. 610 1.00 44. .36 M O

ATOM 20325 OW WAT M 204 7. ,670 -9. 143 -11. 397 1.00 42. ,36 M O

ATOM 20328 OW WAT M 205 -44. ,417 -13. 640 -54. 630 1.00 32. 68 M O

ATOM 20331 OW WAT M 206 -51. ,056 -15. 278 -71. 657 1.00 46. 23 M 0

ATOM 20334 OW WAT M 207 -19. ,166 -0. 866 -28. 795 1.00 54. ,19 M 0

ATOM 20337 OW WAT M 208 -34. 876 3. 584 22. 311 1.00 49. ,63 M O

ATOM 20340 OW WAT M 209 -27. ,447 5. 751 7. 753 1.00 47. ,66 M 0

ATOM 20343 OW WAT M 210 -32. ,537 0. 412 5. 862 1.00 43. ,21 M O

ATOM 20346 OW WAT M 211 20. ,997 6. 581 -39. 935 1.00 36. ,35 M O

ATOM 20349 OW WAT M 212 -18. 490 29. 455 -20. 127 1.00 44. ,07 M O

ATOM 20352 OW WAT M 213 -49. ,488 8. 766 -72. 730 1.00 50. ,63 M 0

ATOM 20355 OW WAT M 214 -29. ,948 -9. 863 -52. 454 1.00 42. ,81 M 0

ATOM 20358 OW WAT M 215 -32. ,679 -11. 868 -51. 105 1.00 43. ,01 M O

ATOM 20361 OW WAT M 216 -34. ,007 -5. 817 -45. 150 1.00 39. ,56 M 0

ATOM 20364 OW WAT M 217 -40. 472 3. 212 -56. 364 1.00 34. ,12 M O

ATOM 20367 OW WAT M 218 -10. 948 21. 444 -1. 107 1.00 38. ,08 M O

ATOM 20370 OW WAT M 219 0. ,378 7. 134 -17. 753 1.00 40. ,40 M 0

ATOM 20373 OW WAT M 220 -33. 966 -2. 262 -73. 773 1.00 40. ,20 M 0

ATOM 20376 OW WAT M 221 -78. ,319 14. 018 -94. 270 1.00 56. ,48 M 0

ATOM 20379 OW WAT M 222 -27. ,405 0. 184 3. 530 1.00 35. ,87 M O

ATOM 20382 OW WAT M 223 14. 124 13. 977 -13. 837 1.00 31. 89 M O

ATOM 20385 OW WAT M 224 -41. ,206 2. 393 -76. 952 1.00 40. ,56 M 0

ATOM 20388 OW WAT M 225 24. ,887 -10. 898 -40. 213 1.00 44. ,47 M O

ATOM 20391 OW WAT M 226 -43. ,732 17. 169 3. 248 1.00 54. ,35 M 0

ATOM 20394 OW WAT M 227 -31. 852 33. 968 11. 042 1.00 47. 06 M 0

ATOM 20397 OW WAT M 228 -38. ,345 -20. 706 -23. 200 1.00 53. 95 M O

ATOM 20400 OW WAT M 229 -55. ,298 3. 976 -68. 786 1.00 31.49 M O

ATOM 20403 OW WAT M 230 17. 633 -0. 325 -31. 020 1.00 41. 65 M O

ATOM 20406 OW WAT M 231 -72. 629 6. 333 -74. 856 1.00 45. ,83 M O

ATOM 20409 OW WAT M 232 -23. ,586 6. 468 -17. 039 1.00 32. ,63 M O

ATOM 20412 OW WAT M 233 -17. ,675 -5. ,414 -35. 280 1.00 43. ,67 M O

ATOM 20415 OW WAT M 234 -30. 223 15. 948 -4. 886 1.00 40. ,87 M 0

ATOM 20418 OW WAT M 235 29. ,530 -6. 556 -18. 684 1.00 48. ,83 M 0

ATOM 20421 OW WAT M 236 -43. ,897 19. 551 19. 673 1.00 38. ,78 M O

ATOM 20424 OW WAT M 237 -40. ,872 11. 676 -59. 087 1.00 46. ,09 M O

ATOM 20427 OW WAT M 238 -40. 633 5. 880 -71. 412 1.00 39. ,16 M O

ATOM 20430 OW WAT M 239 -28. ,261 7. 474 -2. 116 1.00 38. ,58 M 0

ATOM 20433 OW WAT M 240 -78. ,546 -2. ,935 -67. 304 1.00 48. ,09 M O

ATOM 20436 OW WAT M 241 32. ,784 -1. ,582 -11. 919 1.00 52. ,57 M 0

ATOM 20439 OW WAT M 242 -34. 068 0. ,493 -34. 524 1.00 47. ,02 M O

ATOM 20442 OW WAT M 243 -52. ,441 -33. ,340 -49. 131 1.00 38. ,72 M 0

ATOM 20445 OW WAT M 244 7. ,482 36. ,315 -13. 735 1.00 42. ,31 M 0

ATOM 20448 OW WAT M 245 -13. ,986 19. 404 -22. 198 1.00 38. ,80 M 0

ATOM 20451 OW WAT M 246 -33. ,887 4. 772 26. 254 1.00 51. ,11 M O

ATOM 20454 OW WAT M 247 -45. ,413 10. 056 -66. 121 1.00 49. ,81 M O

ATOM 20457 OW WAT M 248 -16. ,400 11. ,455 -22. 590 1.00 41. .97 M O

ATOM 20460 OW WAT M 249 23. ,512 13. 193 -14. 929 1.00 45. ,93 M 0

ATOM 20463 OW WAT M 250 17. 815 27. 921 -14. 688 1.00 31. ,37 M 0

ATOM 20466 OW WAT M 251 -30. ,828 -25. 574 -49. 466 1.00 45. ,31 M 0

ATOM 20469 OW WAT M 252 -72. 635 6. 628 -62. 158 1.00 40. ,26 M 0

ATOM 20472 OW WAT M 253 -39. ,364 32. ,072 21. 510 1.00 35. ,72 M 0

ATOM 20475 OW WAT M 254 14. ,742 8. ,901 -17. 465 1.00 54. ,28 M 0

ATOM 20478 OW WAT M 255 -8. ,828 -11. ,632 -40. 110 1.00 41, .76 M 0

ATOM 20481 OW WAT M 256 -54. ,330 -30. ,264 -46. 070 1.00 46, .98 M 0

ATOM 20484 OW WAT M 257 -39. ,400 1. ,833 -40. 710 1.00 46, .00 M 0

ATOM 20487 OW WAT M 258 -8. ,468 -4. ,808 -43. 046 1.00 61, ,43 M 0

ATOM 20490 OW WAT M 259 -50. ,652 27. 918 18. 120 1.00 44, .92 M 0

ATOM 20493 OW WAT M 260 0. ,644 31.751 -19. 881 1.00 37, .94 M 0

ATOM 20496 OW WAT M 261 -63. ,924 -2. ,264 -46. 149 1.00 51, ,29 M 0

ATOM 20499 OW WAT M 262 -80. ,111 11. ,800 -94. 259 1.00 54. ,73 M 0

ATOM 20502 OW WAT M 263 -66. .588 -3. ,753 -46. 057 1.00 54, .14 M 0

ATOM 20505 OW WAT W 1 -18. ,650 -24. ,706 -46. 790 1.00 52, .98 W 0

ATOM 20508 OW WAT W 2 14. ,212 8. ,008 -34. 289 1.00 40, .97 W 0

ATOM 20511 OW WAT W 3 -71. ,659 15. ,787 -67. 171 1.00 83, .16 W 0 human fD_Fab

ATOM 20514 OW WAT W 4 18. 991 13. 948 -35. 562 1.00 44. 13 W O

ATOM 20517 OW WAT W 5 -80. 750 19. 086 -92. 525 1.00 53. 18 W O

ATOM 20520 OW WAT W 6 -63. 802 12. 489 -78. 236 1.00 47. 79 W O

ATOM 20523 OW WAT W 7 -32. 816 -29. ,211 -38. 814 1.00 31. 83 w 0

ATOM 20526 OW WAT W 8 -16. 878 -21. ,901 -43. 107 1.00 41. 50 w O

ATOM 20529 OW WAT W 9 -23. 985 1. 126 28. 393 1.00 43. 31 w O

ATOM 20532 OW WAT W 10 -0. 267 2. 930 -3. 665 1.00 56. 96 w O

ATOM 20535 OW WAT W 11 -2. 416 -13. 003 -33. 505 1.00 49. 79 w O

ATOM 20538 OW WAT W 12 -26. 020 -23. 652 -40. 734 1.00 45. 36 w 0

ATOM 20541 OW WAT W 13 -11. 114 7. 787 6. 200 1.00 36. 09 w 0

ATOM 20544 OW WAT W 14 -63. 725 -18. ,214 -72. 622 1.00 44. 40 w O

ATOM 20547 OW WAT W 15 36. 358 10. ,061 -30. 549 1.00 35. 07 w 0

ATOM 20550 OW WAT W 16 21. 410 -1. 252 -41. 576 1.00 41.56 w 0

ATOM 20553 OW WAT W 17 -8. 769 34. 774 -11. 309 1.00 44. 37 w 0

ATOM 20556 OW WAT w 18 -11. 416 -4. 646 -32. 187 1.00 53. 07 w 0

ATOM 20559 OW WAT w 19 -62. 647 -23. 258 -58. 113 1.00 41. 52 w 0

ATOM 20562 OW WAT w 20 -35. 863 5. 769 -49. 624 1.00 46. 92 w 0

ATOM 20565 OW WAT w 21 -33. 612 10. 645 -4. 724 1.00 47. 26 w 0

ATOM 20568 OW WAT w 22 -6. 454 -8. ,419 -12. 348 1.00 55. 20 w 0

ATOM 20571 OW WAT w 23 -24. 794 -0. ,792 7. 732 1.00 41.49 w 0

ATOM 20574 OW WAT w 24 -27. 161 3. 952 -27. 015 1.00 48. 23 w 0

ATOM 20577 OW WAT w 25 -33. 414 -31. 513 -37. 614 1.00 44. 12 w 0

ATOM 20580 OW WAT w 26 -15. 074 13. 693 10. 234 1.00 51. 44 w 0

ATOM 20583 OW WAT w 27 -22. 599 16. 990 -15. 039 1.00 40. 98 w 0

ATOM 20586 OW WAT w 28 9. 523 6. 704 -28. 424 1.00 46. 54 w 0

ATOM 20589 OW WAT w 29 -83. 314 26. ,507 -80. 625 1.00 53. ,01 w 0

ATOM 20592 OW WAT w 30 -44. 150 -1. ,635 -54. 839 1.00 36. 28 w 0

ATOM 20595 OW WAT w 31 -4. 641 -11. ,254 -33. 664 1.00 47. 35 w 0

ATOM 20598 OW WAT w 32 -32. 245 26.011 33. 198 1.00 49. 62 w 0

ATOM 20601 OW WAT w 33 -11.065 25. 645 -7. 032 1.00 32. 23 w 0

ATOM 20604 OW WAT w 34 -21. 148 24. 067 3. 149 1.00 45. 81 w 0

ATOM 20607 OW WAT w 35 -49. 520 -17. 607 -47. 737 1.00 36. 50 w 0

ATOM 20610 OW WAT w 36 -31. 425 12. 357 -57. 004 1.00 50. 12 w 0

ATOM 20613 OW WAT w 37 32. 817 12. 986 -38. 638 1.00 40. ,39 w 0

ATOM 20616 OW WAT w 38 -21. 121 -30. ,765 -35. 356 1.00 41. 29 w 0

ATOM 20619 OW WAT w 39 -57. 086 -18. ,468 -73. 899 1.00 54. 32 w 0

ATOM 20622 OW WAT w 40 -27. 877 -18. ,428 -42. 548 1.00 52. 08 w 0

ATOM 20625 OW WAT w 41 -75. 595 0. ,624 -57. 248 1.00 53. 05 w 0

ATOM 20628 OW WAT w 42 -67. 633 6. 652 -62. 866 1.00 41. 37 w 0

ATOM 20631 OW WAT w 43 15. 128 20.585 -8. 186 1.00 45. 32 w 0

ATOM 20634 OW WAT w 44 -57. 162 -3. 567 -83. 174 1.00 55. 52 w 0

ATOM 20637 OW WAT w 45 -69. 453 10. ,000 -75. 560 1.00 53. ,16 w 0

ATOM 20640 OW WAT w 46 15. 366 4. ,138 -26. 649 1.00 50. 32 w 0

ATOM 20643 OW WAT w 47 -22. 585 2. ,805 9. 475 1.00 47. ,10 w 0

ATOM 20646 OW WAT w 48 -23. 313 1. ,604 20. 977 1.00 43. ,04 w 0

ATOM 20649 OW WAT w 49 -32. 763 36. ,030 23. 045 1.00 52. 32 w 0

ATOM 20652 OW WAT w 50 -47. 114 12. ,452 32. 975 1.00 49. 61 w 0

ATOM 20655 OW WAT w 51 -39. 198 -12. ,448 -57. 689 1.00 46. 95 w 0

ATOM 20658 OW WAT w 52 -35. 660 3. .155 10. ,626 1.00 44. ,00 w 0

ATOM 20661 OW WAT w 53 19. 851 12. ,608 -10. ,868 1.00 52. ,03 w 0

ATOM 20664 OW WAT w 54 -21. 186 11.027 29. 892 1.00 53. ,09 w 0

ATOM 20667 OW WAT w 55 22. 199 -10. ,344 -39. 699 1.00 48. ,04 w 0

ATOM 20670 OW WAT w 56 -16. 626 -17. ,979 -20. 506 1.00 51. ,87 w 0

ATOM 20673 OW WAT w 57 -53. 691 -20. ,060 -77. 553 1.00 39. ,79 w 0

ATOM 20676 OW WAT w 58 -45. 883 -0. ,267 -53. 476 1.00 46. ,75 w 0

ATOM 20679 OW WAT w 59 -53. 421 0. ,456 -55. 389 1.00 38. ,84 w 0

ATOM 20682 OW WAT w 60 -7. 552 6, ,378 -28. ,567 1.00 52. ,97 w 0

ATOM 20685 OW WAT w 61 7. 520 -13. ,478 -29. ,555 1.00 48. ,30 w 0

ATOM 20688 OW WAT w 62 -25. 789 -3. ,244 -57. ,626 1.00 49. ,42 w 0

ATOM 20691 OW WAT w 63 4. 831 -15. .271 -27. ,469 1.00 42. ,72 w 0

ATOM 20694 OW WAT w 64 -43. 424 6. ,810 20. 975 1.00 49. ,76 w 0

ATOM 20697 OW WAT w 65 22. 685 8. 896 -39. 495 1.00 44. ,21 w 0

ATOM 20700 OW WAT w 66 -76. 680 -2. ,683 -61.561 1.00 43. ,77 w 0

ATOM 20703 OW WAT w 67 -4. 983 -11.952 -18. ,184 1.00 52. .25 w 0

ATOM 20706 OW WAT w 68 -25. 852 -0. .017 27. ,207 1.00 39. ,78 w 0

ATOM 20709 OW WAT w 69 -27. 109 22. .289 -11. 700 1.00 50. ,77 w 0

ATOM 20712 OW WAT w 70 -44. 672 0. .142 -82. 184 1.00 37. .71 w 0

ATOM 20715 OW WAT w 71 3. 536 8. .356 -16. 461 1.00 53. 64 w 0 human fD_Fab

ATOM 20718 OW WAT W 72 -51. .995 14. ,726 30, .299 1.00 55. .20 W O

ATOM 20721 OW WAT w 73 -50. ,538 -31. ,362 -45, .014 1.00 51. .14 w O

ATOM 20724 OW WAT w 74 -40. .068 -14. ,833 -23. .935 1.00 48. ,95 w O

ATOM 20727 OW WAT w 75 -31. ,128 -16. 292 -41. .631 1.00 48. ,24 w O

ATOM 20730 OW WAT w 76 -28. ,610 5. 991 -26. ,779 1.00 48. ,38 w O

ATOM 20733 OW WAT w 77 -47. ,633 -15. ,661 -47. ,480 1.00 41. ,96 w O

ATOM 20736 OW WAT w 78 -12. 287 5. ,350 6. ,267 1.00 29. ,94 w O

ATOM 20739 OW WAT w 79 9. ,511 -15. ,420 -28. ,862 1.00 39. ,05 w 0

ATOM 20742 OW WAT w 80 -12. ,205 -7. ,558 -33. .715 1.00 46. ,15 w 0

ATOM 20745 OW WAT w 81 -20. 092 13. ,331 30. ,154 1.00 51. ,96 w 0

ATOM 20748 OW WAT w 82 -7. ,643 -10. ,370 -9. .140 1.00 54. ,79 w 0

END

cyno fD_Fab

Appendix IB: Structural coordinates cyno factor D Fab

REMARK 3

REMARK 3

REMARK 3 PROGRAM REFMAC 5 .2 .0019

REMARK 3 AUTHORS MURSHUDOV, AGIN , DODSON

REMARK 3

REMARK 3 REFINEMENT TARGET : MAXIMUM LIKELIHOOD

REMARK 3

REMARK 3 DATA USED IN REFINEMENT.

REMARK 3 RESOLUTION RANGE HIGH (ANGSTROMS 2 . 10

REMARK 3 RESOLUTION RANGE LOW (ANGSTROMS 20.00

REMARK 3 DATA CUTOFF (SIGMA(F) NONE

REMARK 3 COMPLETENESS FOR RANGE ( 91. 51

REMARK 3 NUMBER OF REFLECTIONS 100140

REMARK 3

REMARK 3 FIT TO DATA USED IN REFINEMENT.

REMARK 3 CROSS-VALIDATION METHOD THROUGHOUT

REMARK 3 FREE R VALUE TEST SET SELECTION RANDOM

REMARK 3 R VALUE (WORKING + TEST SET) 0. 21397

REMARK 3 R VALUE (WORKING SET) 0.21105

REMARK 3 FREE R VALUE 0.26960

REMARK 3 FREE R VALUE TEST SET SIZE (%) 5 .0

REMARK 3 FREE R VALUE TEST SET COUNT 5291

REMARK 3

REMARK 3 FIT IN THE HIGHEST RESOLUTION BIN.

REMARK 3 TOTAL NUMBER OF BINS USED 25

REMARK 3 BIN RESOLUTION RANGE HIGH 2 . 100

REMARK 3 BIN RESOLUTION RANGE LOW 2 . 143

REMARK 3 REFLECTION IN BIN (WORKING SET) 5661

REMARK 3 BIN COMPLETENESS (WORKING+TEST) (%) 88. 63

REMARK 3 BIN R VALUE (WORKING SET) 0. 333

REMARK 3 BIN FREE R VALUE SET COUNT 295

REMARK 3 BIN FREE R VALUE 0.404

REMARK 3

REMARK 3 NUMBER OF NON-HYDROGEN ATOMS USED IN REFINEMENT.

REMARK 3 ALL ATOMS : 10774

REMARK 3

REMARK 3 B VALUES.

REMARK 3 FROM WILSON PLOT (A**2) NULL

REMARK 3 MEAN B VALUE (OVERALL, A* *2) 27 . 396

REMARK 3 OVERALL ANISOTROPIC B VALUE.

REMARK 3 Bll A**2 -2 .02

REMARK 3 B22 A**2 -0. 95

REMARK 3 B33 A**2 1. 58

REMARK 3 B12 A**2 0.00

REMARK 3 B13 A**2 -2 . 34

REMARK 3 B23 A**2 0.00

REMARK 3

REMARK 3 ESTIMATED OVERALL COORDINATE ERROR.

REMARK 3 ESU BASED ON R VALUE 0. 202 REMARK 3 ESU BASED ON FREE R VALUE 0. 195 REMARK 3 ESU BASED ON MAXIMUM LIKELIHOOD 0. 177 REMARK 3 ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD 13 . 178 REMARK 3

REMARK 3 CORRELATION COEFFICIENTS.

REMARK 3 CORRELATION COEFFICIENT FO-FC 0. 955

REMARK 3 CORRELATION COEFFICIENT FO-FC FREE : 0.926

REMARK 3

REMARK 3 RMS DEVIATIONS FROM IDEAL V/ ES COUNT RMS WEIGHT REMARK 3 BOND LENGTHS REFINED ATOMS (A) 10201 0 010 0. 022 REMARK 3 BOND LENGTHS OTHERS (A) 6856 0 002 0. 020 REMARK 3 BOND ANGLES REFINED ATOMS DEGREES) 13877 1 348 1. 964 REMARK 3 BOND ANGLES OTHERS DEGREES) 16745 0 864 3 . 004 REMARK 3 TORSION ANGLES, PERIOD 1 DEGREES) 1303 7 428 5 . 000 REMARK 3 TORSION ANGLES, PERIOD 2 DEGREES) 406 35 270 24. 138 REMARK 3 TORSION ANGLES, PERIOD 3 DEGREES) 1632 15 851 15 . 000 REMARK 3 TORSION ANGLES, PERIOD 4 DEGREES) 58 16 188 15 . 000 cyno fD_Fab

REMARK 3 CHIRAL-CENTER RESTRAINTS (A**3} 1566 0.076 0.200

REMARK 3 GENERAL PLANES REFINED ATOMS (Aj 11335 0.004 0.020

REMARK 3 GENERAL PLANES OTHERS (A) 1941 0.001 0.020

REMARK 3 NON-BONDED CONTACTS REFINED ATOMS (A) 1766 0. 183 0. 200

REMARK 3 NON-BONDED CONTACTS OTHERS (A) 7046 0. 196 0. 200

REMARK 3 NON-BONDED TORSION REFINED ATOMS (A) 4699 0. 171 0. 200

REMARK 3 NON-BONDED TORSION OTHERS (A) 5649 0.085 0.200

REMARK 3 H-BOND (X...Y) REFINED ATOMS (A) 645 0. 189 0.200

REMARK 3 POTENTIAL METAL-ION REFINED ATOMS (A) 5 0.096 0.200

REMARK 3 SYMMETRY VDW REFINED ATOMS (A) 26 0. 238 0. 200

REMARK 3 SYMMETRY VDW OTHERS (A) 43 0. 165 0. 200

REMARK 3 SYMMETRY H-BOND REFINED ATOMS (A) 22 0.225 0. 200

REMARK 3 SYMMETRY METAL-ION REFINED ATOMS (A) 2 0. 347 0. 200

REMARK 3

REMARK 3 ISOTROPIC THERMAL FACTOR RESTRAINTS . COUNT RMS WEIGHT

REMARK 3 MAIN-CHAIN BOND REFINED ATOMS (A**2 8346 3 . 108 2 . 500

REMARK 3 MAIN-CHAIN BOND OTHER ATOMS (A**2 2652 0. 650 2. 500

REMARK 3 MAIN-CHAIN ANGLE REFINED ATOMS (Α**2 ^Λ 10525 3 .958 5 .000

REMARK 3 SIDE-CHAIN BOND REFINED ATOMS (A**2 4285 2 .990 2 . 500

REMARK 3 SIDE-CHAIN ANGLE REFINED ATOMS (A**2 3352 4.086 5 .000

REMARK 3

REMARK 3 NCS RESTRAINTS STATISTICS

REMARK 3 NUMBER OF DIFFERENT NCS GROUPS :

REMARK 3

REMARK 3 NCS GROUP NUMBER :

REMARK 3 CHAIN NAMES : A B

REMARK 3 NUMBER OF COMPONENTS NCS GROUP : 1

REMARK 3 COMPONENT C SSSEQI TO C SSSEQI

REMARK 3 1 A 16 A 243

REMARK 3 1 B 16 B 243 6

REMARK 3 GROUP CHAIN COUNT RMS WEIGHT

REMARK 3 LOOSE POSITIONAL A (A) 2939 0. 53 5 .00

REMARK 3 LOOSE THERMAL A (A**2) 2939 4.08 10.00

REMARK 3

REMARK 3 NCS GROUP NUMBER :

REMARK 3 CHAIN NAMES : L D

REMARK 3 NUMBER OF COMPONENTS NCS GROUP : 2

REMARK 3 COMPONENT C SSSEQI TO C SSSEQI

REMARK 3 1 L 1 L 109

REMARK 3 1 D 1 D 109

REMARK 3 2 L 110 L 214

REMARK 3 2 D 110 D 214 6

REMARK 3 GROUP CHAIN COUNT RMS WEIGHT

REMARK 3 LOOSE POSITIONAL (A) 2731 0.44 5 .00

REMARK 3 LOOSE THERMAL (A**2) 2731 2 . 30 10.00

REMARK 3

REMARK 3 NCS GROUP NUMBER : 3

REMARK 3 CHAIN NAMES : H E

REMARK 3 NUMBER OF COMPONENTS NCS GROUP : 1

REMARK 3 COMPONENT C SSSEQI TO C SSSEQI

REMARK 3 1 H 1 H 120

REMARK 3 1 E 1 E 120 6

REMARK 3 GROUP CHAIN COUNT RMS WEIGHT

REMARK 3 LOOSE POSITIONAL H 1473 0. 29 5 .00

REMARK 3 LOOSE THERMAL H (A 1473 2 . 35 10.00

REMARK 3

REMARK 3

REMARK 3 TLS DETAILS

REMARK 3 NUMBER OF TLS GROUPS

REMARK 3 ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY

REMARK 3

REMARK 3 TLS GROUP : 1

REMARK 3 NUMBER OF COMPONENTS GROUP 10

REMARK 3 COMPONENTS C SSSEQI TO C SSSEQI

REMARK 3 RESIDUE RANGE : A 16 A 243

REMARK 3 RESIDUE RANGE : L 1 L 109

REMARK 3 RESIDUE RANGE : L 110 L 214

REMARK 3 RESIDUE RANGE : H 1 H 120 cyno fD_Fab

REMARK 3 RESIDUE RANGE : H 121 H 224

REMARK 3 RESIDUE RANGE : B 16 B 243

REMARK 3 RESIDUE RANGE : D 1 D 109

REMARK 3 RESIDUE RANGE : D 110 D 214

REMARK 3 RESIDUE RANGE : E 1 E 120

REMARK 3 RESIDUE RANGE : E 121 E 224

REMARK 3 ORIGIN FOR THE GROUP (A): 26. 7721 - 32.1960 -551.5126

REMARK 3 T TENSOR

REMARK 3 Til: -0.1168 T22: -0.1381

REMARK 3 T33: -0.1325 T12: 0.0139

REMARK 3 T13: -0.0040 T23: -0.0132

REMARK 3 L TENSOR

REMARK 3 Lll: 0.5831 L22: 0.5482

REMARK 3 L33: 0.4061 L12: -0.2108

REMARK 3 L13: 0.1924 L23: -0.0152

REMARK 3 S TENSOR

REMARK 3 Sll: -0.0559 S12: -0.1498 S13: 0.0388

REMARK 3 S21: 0.1239 S22: 0.0611 S23: -0.0323

REMARK 3 S31: 0.0494 S32: -0.0124 S33: -0.0052

REMARK 3

REMARK 3

REMARK 3 BULK SOLVENT MODELLING.

REMARK 3 METHOD USED : MASK

REMARK 3 PARAMETERS FOR MASK CALCULATION

REMARK 3 VDW PROBE RADIUS 1.40

REMARK 3 ION PROBE RADIUS 0.80

REMARK 3 SHRINKAGE RADIUS 0.80

REMARK 3

REMARK 3 OTHER REFINEMENT REMARKS :

REMARK 3 HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITION

REMARK 3

SSBOND 1 CYS A 41 CYS A 57

SSBOND 2 CYS A 138 CYS A 204

SSBOND 3 CYS A 169 CYS A 185

SSBOND 4 CYS A 194 CYS A 219

SSBOND 5 CYS L 23 CYS L 88

SSBOND 6 CYS L 134 CYS L 194

SSBOND 7 CYS H 22 CYS H 96

SSBOND 8 CYS H 148 CYS H 204

SSBOND 9 CYS B 41 CYS B 57

SSBOND 10 CYS B 138 CYS B 204

SSBOND 11 CYS B 169 CYS B 185

SSBOND 12 CYS B 194 CYS B 219

SSBOND 13 CYS D 23 CYS D 88

SSBOND 14 CYS D 134 CYS D 194

SSBOND 15 CYS E 22 CYS E 96

SSBOND 16 CYS E 148 CYS E 204

CISPEP 1 SER L 7 PRO L 8 0.00

CISPEP 2 LEU L 94 PRO L 95 0.00

CISPEP 3 TYR L 140 PRO L 141 0.00

CISPEP 4 GLU H 99 GLY H 100 0.00

CISPEP 5 PHE H 154 PRO H 155 0.00

CISPEP 6 GLU H 156 PRO H 157 0.00

CISPEP 7 GLU E 99 GLY E 100 0.00

LINK SER E 136 GLY E 142 gap

CISPEP 8 PHE E 154 PRO E 155 0.00

CISPEP 9 GLU E 156 PRO E 157 0.00

LINK C GLY H 101 N VAL H 108 TRANS

LINK C GLY E 101 N VAL E 108 TRANS

CISPEP 10 SER D 7 PRO D 8 0.00

CISPEP 11 LEU D 94 PRO D 95 0.00

CISPEP 12 TYR D 140 PRO D 141 0.00

CRYST1 182 .205 80.673 142. 575 90.00 107 .27 90.00 C 1 2

SCALEl 0.005488 0.000000 0.001706 0. 00000

SCALE2 0.000000 0.012396 0.000000 0. 00000

SCALE3 0.000000 0.000000 0.007345 0. 00000

ATOM 1 N ILE A 16 -12.477 -20.126 -72 .065 1.00 A N

ATOM 2 CA ILE A 16 -13.046 -20.518 -70 .743 1.00 A C cyno fD_Fab

ATOM 4 CB ILE A 16 -14, .540 -20. 163 -70. 650 1.00 17. 19 A C

ATOM 6 CGI ILE A 16 -14. .756 -18. 660 -70. 832 1.00 16. 04 A C

ATOM 9 CDl ILE A 16 -14. ,257 -17. 844 -69. 687 1.00 12. 95 A c

ATOM 13 CG2 ILE A 16 -15. .131 -20. 590 -69. 291 1.00 18. ,24 A c

ATOM 17 C ILE A 16 -12. .869 -22. 019 -70. 517 1.00 25. ,77 A c

ATOM 18 O ILE A 16 -13. .363 -22. 825 -71. 302 1.00 30. ,65 A 0

ATOM 22 N LEU A 17 -12. .192 -22. 388 -69. 432 1.00 26. ,78 A N

ATOM 23 CA LEU A 17 -12. ,044 -23. 792 -69. 057 1.00 26. ,56 A c

ATOM 25 CB LEU A 17 -10. .650 -24. 075 -68. 502 1.00 29. 19 A c

ATOM 28 CG LEU A 17 -10. ,218 -25. 538 -68. 433 1.00 29. 19 A c

ATOM 30 CDl LEU A 17 -9. .804 -26. 012 -69. 827 1.00 30. 15 A c

ATOM 34 CD2 LEU A 17 -9. 083 -25. 733 -67. 461 1.00 31.64 A c

ATOM 38 C LEU A 17 -13. ,076 -24. 125 -68. 002 1.00 25. 50 A c

ATOM 39 O LEU A 17 -13. ,225 -23. 388 -67. 052 1.00 24. 96 A 0

ATOM 41 N GLY A 18 -13, ,779 -25. 245 -68. 171 1.00 27. ,34 A N

ATOM 42 CA GLY A 18 -14. ,694 -25. 745 -67. 150 1.00 26. ,28 A C

ATOM 45 C GLY A 18 -16, ,056 -25. 127 -67. 224 1.00 25. ,74 A c

ATOM 46 O GLY A 18 -16. ,859 -25. 261 -66. 294 1.00 27. 40 A 0

ATOM 48 N GLY A 19 -16. ,327 -24. 459 -68. 340 1.00 24. 98 A N

ATOM 49 CA GLY A 19 -17. ,570 -23. 750 -68. 525 1.00 30. 62 A c

ATOM 52 C GLY A 19 -18. ,585 -24. 544 -69. 326 1.00 34. 86 A c

ATOM 53 O GLY A 19 -18. ,456 -25. 763 -69. 508 1.00 37. 52 A 0

ATOM 55 N ARG A 20 -19. ,609 -23. 831 -69. 780 1.00 33. 69 A N

ATOM 56 CA ARG A 20 -20. ,627 -24. 359 -70. 680 1.00 31. 69 A c

ATOM 58 CB ARG A 20 -21.893 -24. 808 -69. 914 1.00 35. ,24 A c

ATOM 61 CG ARG A 20 -22. ,318 -23. 858 -68. 817 1.00 40. 28 A c

ATOM 64 CD ARG A 20 -23. ,727 -24. 109 -68. 232 1.00 41. 93 A c

ATOM 67 NE ARG A 20 -23. ,986 -23. 173 -67. 119 1.00 44. 05 A N

ATOM 69 CZ ARG A 20 -24. ,824 -22. 126 -67. 135 1.00 45. 78 A c

ATOM 70 NHl ARG A 20 -25. ,567 -21. 834 -68. 207 1.00 48. 14 A N

ATOM 73 NH2 ARG A 20 -24. ,921 -21. 352 -66. 055 1.00 41. 86 A N

ATOM 76 C ARG A 20 -20. ,942 -23. 249 -71. 674 1.00 26. 68 A c

ATOM 77 O ARG A 20 -20. ,586 -22. 072 -71. 463 1.00 17. 73 A 0

ATOM 79 N GLU A 21 -21.597 -23. 617 -72. 764 1.00 26. 61 A N

ATOM 80 CA GLU A 21 -22. ,067 -22. 631 -73. 722 1.00 27. ,09 A c

ATOM 82 CB GLU A 21 -22. ,765 -23. 315 -74. 889 1.00 28. ,01 A c

ATOM 85 CG GLU A 21 -23. ,000 -22. 409 -76. 067 1.00 28. ,48 A c

ATOM 88 CD GLU A 21 -23. ,779 -23. 093 -77. 146 1.00 29. ,03 A c

ATOM 89 OEl GLU A 21 -23. ,656 -24. 329 -77. 269 1.00 32. 30 A 0

ATOM 90 OE2 GLU A 21 -24. ,515 -22. 402 -77. 867 1.00 26. 79 A 0

ATOM 91 C GLU A 21 -23. ,016 -21. 614 -73. 076 1.00 24. ,87 A c

ATOM 92 0 GLU A 21 -23. 990 -21. 972 -72. 416 1.00 24. 39 A 0

ATOM 94 N ALA A 22 -22. 708 -20. 340 -73. 284 1.00 25. 10 A N

ATOM 95 CA ALA A 22 -23. ,551 -19. ,253 -72. 844 1.00 23. ,99 A c

ATOM 97 CB ALA A 22 -22. ,834 -17. 920 -73. 087 1.00 16. ,28 A C

ATOM 101 C ALA A 22 -24. .882 -19. 306 -73. 604 1.00 24. ,75 A c

ATOM 102 0 ALA A 22 -24. ,941 -19. 783 -74. 733 1.00 22. ,68 A 0

ATOM 104 N GLU A 23 -25. ,962 -18. 851 -72. 976 1.00 27. ,04 A N

ATOM 105 CA GLU A 23 -27, ,212 -18. ,651 -73. 694 1.00 27. ,93 A c

ATOM 107 CB GLU A 23 -28. ,322 -18. 212 -72. 749 1.00 32. ,84 A c

ATOM 110 CG GLU A 23 -28, ,932 -19. 311 -71. 901 1.00 37. ,53 A c

ATOM 113 CD GLU A 23 -29. ,887 -18. 734 -70. 868 1.00 42. ,31 A c

ATOM 114 OEl GLU A 23 -29. ,390 -18. 099 -69. 908 1.00 48. ,10 A 0

ATOM 115 OE2 GLU A 23 -31.128 -18. 884 -71. 027 1.00 48. ,38 A 0

ATOM 116 C GLU A 23 -27. ,000 -17. ,576 -74. 754 1.00 20. ,26 A c

ATOM 117 0 GLU A 23 -26. ,403 -16. ,549 -74. 480 1.00 13. ,10 A 0

ATOM 119 N ALA A 24 -27. ,500 -17. 805 -75. 963 1.00 20. ,83 A N

ATOM 120 CA ALA A 24 -27. ,210 -16. 906 -77. 081 1.00 20. ,13 A c

ATOM 122 CB ALA A 24 -27, ,834 -17. ,438 -78. 376 1.00 17. ,35 A c

ATOM 126 C ALA A 24 -27. ,720 -15. ,506 -76. 769 1.00 21. ,16 A c

ATOM 127 0 ALA A 24 -28. ,908 -15. ,311 -76. 497 1.00 25. ,09 A 0

ATOM 129 N HIS A 25 -26. ,808 -14. ,544 -76. 790 1.00 19. ,39 A N

ATOM 130 CA HIS A 25 -27. ,113 -13. ,117 -76. 625 1.00 17. ,07 A c

ATOM 132 CB HIS A 25 -28. ,096 -12. ,625 -77. 691 1.00 17, ,98 A c

ATOM 135 CG HIS A 25 -27. ,824 -13. ,149 -79. 066 1.00 14, ,73 A c

ATOM 136 NDl HIS A 25 -26, ,746 -12. ,740 -79. 819 1.00 15. ,69 A N

ATOM 138 CE1 HIS A 25 -26. ,758 -13. ,373 -80. 978 1.00 15, ,54 A c

ATOM 140 NE2 HIS A 25 -27. ,796 -14. ,184 -81. 001 1.00 11. .60 A N cyno fD_Fab

ATOM 142 CD2 HIS A 25 -28.476 -14. 069 -79. ,812 1.00 15. ,49 A C

ATOM 144 C HIS A 25 -27.613 -12. 718 -75. ,221 1.00 16. ,72 A C

ATOM 145 O HIS A 25 -28.197 -11. 668 -75. ,070 1.00 16. 69 A 0

ATOM 147 N ALA A 26 -27.321 -13. 539 -74. ,211 1.00 21.13 A N

ATOM 148 CA ALA A 26 -27.677 -13. 281 -72. ,811 1.00 19. ,73 A c

ATOM 150 CB ALA A 26 -27.602 -14. 570 -72. Oil 1.00 19. 47 A c

ATOM 154 C ALA A 26 -26.775 -12. 252 -72. 168 1.00 21. 51 A c

ATOM 155 O ALA A 26 -27.114 -11. 700 -71. 125 1.00 26. 85 A 0

ATOM 157 N ARG A 27 -25.619 -12. 034 -72. 790 1.00 24. 12 A N

ATOM 158 CA ARG A 27 -24.625 -11. 068 -72. 379 1.00 23. 20 A c

ATOM 160 CB ARG A 27 -23.323 -11. 791 -72. 026 1.00 17. ,93 A c

ATOM 163 CG ARG A 27 -23.484 -12. 655 -70. 806 1.00 18. ,21 A c

ATOM 166 CD ARG A 27 -22.439 -13. 693 -70. 627 1.00 20. 29 A c

ATOM 169 NE ARG A 27 -22.757 -14. 485 -69. 440 1.00 20. 11 A N

ATOM 171 CZ ARG A 27 -23.645 -15. 475 -69. 409 1.00 17. 77 A c

ATOM 172 NHl ARG A 27 -24.301 -15. 837 -70. 503 1.00 16. 54 A N

ATOM 175 NH2 ARG A 27 -23.866 -16. 120 -68. 280 1.00 17. 12 A N

ATOM 178 C ARG A 27 -24.389 -10. 103 -73. 536 1.00 23. 34 A C

ATOM 179 0 ARG A 27 -23.391 -10. 230 -74. 242 1.00 21. ,56 A 0

ATOM 181 N PRO A 28 -25.312 -9. 141 -73. 730 1.00 19. 52 A N

ATOM 182 CA PRO A 28 -25.280 -8. 288 -74. 920 1.00 22. ,85 A C

ATOM 184 CB PRO A 28 -26.629 -7. 558 -74. ,875 1.00 19. 57 A C

ATOM 187 CG PRO A 28 -27.097 -7. 652 -73. ,492 1.00 22. 07 A C

ATOM 190 CD PRO A 28 -26.445 -8. 815 -72. 842 1.00 22. 42 A c

ATOM 193 C PRO A 28 -24.112 -7. 303 -74. 965 1.00 22. 68 A c

ATOM 194 O PRO A 28 -23.897 -6. 647 -75. 983 1.00 20. 78 A 0

ATOM 195 N TYR A 29 -23.370 -7. 221 -73. 868 1.00 19. 66 A N

ATOM 196 CA TYR A 29 -22.201 -6. 365 -73. 751 1.00 22. 39 A c

ATOM 198 CB TYR A 29 -22.025 -5. 947 -72. ,287 1.00 23. ,79 A c

ATOM 201 CG TYR A 29 -22.194 -7. 088 -71. ,299 1.00 23. 27 A c

ATOM 202 CDl TYR A 29 -21.163 -7. 999 -71. ,077 1.00 20. ,11 A c

ATOM 204 CEl TYR A 29 -21.311 -9. 030 -70. ,192 1.00 23. ,57 A c

ATOM 206 CZ TYR A 29 -22.503 -9. 171 -69. ,495 1.00 22. 70 A c

ATOM 207 OH TYR A 29 -22.645 -10. 213 -68. ,609 1.00 25. 66 A 0

ATOM 209 CE2 TYR A 29 -23.555 -8. 291 -69. ,696 1.00 25. 48 A c

ATOM 211 CD2 TYR A 29 -23.394 -7. 250 -70. ,591 1.00 26. 17 A c

ATOM 213 C TYR A 29 -20.938 -7. 057 -74. ,240 1.00 20. 10 A c

ATOM 214 O TYR A 29 -19.912 -6. 422 -74. 407 1.00 20. 87 A 0

ATOM 216 N MET A 30 -21.026 -8. 362 -74. ,466 1.00 24. 01 A N

ATOM 217 CA MET A 30 -19.895 -9. 168 -74. ,897 1.00 25. ,14 A c

ATOM 219 CB MET A 30 -20.299 -10. 638 -74. ,841 1.00 24. 60 A c

ATOM 222 CG MET A 30 -19.139 -11. 562 -74. ,889 1.00 25. ,03 A c

ATOM 225 SD MET A 30 -18.191 -11. 497 -73. ,370 1.00 26. ,66 A s

ATOM 226 CE MET A 30 -16.571 -11. 678 -74. ,060 1.00 11. 66 A c

ATOM 230 C MET A 30 -19.398 -8. 838 -76. ,310 1.00 26. ,55 A c

ATOM 231 O MET A 30 -20.170 -8. 872 -77. ,279 1.00 26. ,45 A 0

ATOM 233 N ALA A 31 -18.101 -8. 548 -76. ,420 1.00 27. 53 A N

ATOM 234 CA ALA A 31 -17.483 -8. 225 -77. ,690 1.00 27. 28 A c

ATOM 236 CB ALA A 31 -17.032 -6. 756 -77. ,707 1.00 28. ,79 A c

ATOM 240 C ALA A 31 -16.310 -9. 161 -77. ,999 1.00 27. ,46 A c

ATOM 241 O ALA A 31 -15.572 -9. 598 -77. ,118 1.00 26. ,31 A 0

ATOM 243 N SER A 32 -16.174 -9. 494 -79. ,272 1.00 25. ,49 A N

ATOM 244 CA SER A 32 -15.004 -10. 196 -79. 762 1.00 28. ,86 A C

ATOM 246 CB SER A 32 -15.434 -11. 231 -80. 809 1.00 32. ,20 A C

ATOM 249 OG SER A 32 -14.335 -11. 881 -81. 401 1.00 34. ,63 A 0

ATOM 251 C SER A 32 -14.062 -9. 170 -80. 365 1.00 28. ,81 A c

ATOM 252 O SER A 32 -14.405 -8. 523 -81. ,349 1.00 22. ,90 A 0

ATOM 254 N VAL A 33 -12.893 -8. 989 -79. 760 1.00 32. ,95 A N

ATOM 255 CA VAL A 33 -11.852 -8. 149 -80. 362 1.00 33. ,64 A c

ATOM 257 CB VAL A 33 -10.922 -7. 527 -79. ,297 1.00 30. ,76 A c

ATOM 259 CGI VAL A 33 -9.813 -6. 731 -79. ,945 1.00 30. ,92 A c

ATOM 263 CG2 VAL A 33 -11.723 -6. 640 -78. ,353 1.00 25. ,56 A c

ATOM 267 C VAL A 33 -11.076 -9. 012 -81. ,354 1.00 33. ,39 A c

ATOM 268 O VAL A 33 -10.466 -10. Oil -80. ,977 1.00 25. ,22 A 0

ATOM 270 N GLN A 34 -11.144 -8. 645 -82. ,633 1.00 38. ,86 A N

ATOM 271 CA GLN A 34 -10.563 -9. 453 -83. ,705 1.00 39. ,87 A c

ATOM 273 CB GLN A 34 -11.635 -9. 784 -84. ,746 1.00 40. ,71 A c

ATOM 276 CG GLN A 34 -12.933 -10. 328 -84. ,136 1.00 40. ,06 A c cyno fD_Fab

ATOM 279 CD GLN A 34 -13. ,737 -11.166 -85. 096 1.00 37. 65 A C

ATOM 280 OEl GLN A 34 -13. ,861 -10. 830 -86. 269 1.00 42. 71 A 0

ATOM 281 NE2 GLN A 34 -14. 296 -12. 264 -84. 604 1.00 33. 59 A N

ATOM 284 C GLN A 34 -9. ,383 -8. 741 -84. 370 1.00 42. ,61 A C

ATOM 285 O GLN A 34 -9. ,341 -7. 505 -84. 423 1.00 40. ,24 A 0

ATOM 287 N VAL A 35 -8. ,421 -9. 529 -84. 845 1.00 42. 47 A N

ATOM 288 CA VAL A 35 -7. ,338 -9. 024 -85. 694 1.00 45. 56 A C

ATOM 290 CB VAL A 35 -5. ,980 -9. 057 -84. 982 1.00 46. 98 A c

ATOM 292 CGI VAL A 35 -5. ,613 -10. 482 -84. 575 1.00 48. 21 A c

ATOM 296 CG2 VAL A 35 -4. 894 -8. 437 -85. 876 1.00 44. 49 A c

ATOM 300 C VAL A 35 -7. 268 -9. 850 -86. 982 1.00 47. 90 A c

ATOM 301 O VAL A 35 -7. 112 -11. 076 -86. 928 1.00 48. 26 A 0

ATOM 303 N ASN A 36 -7. ,396 -9. 176 -88. 127 1.00 48. ,17 A N

ATOM 304 CA ASN A 36 -7. ,474 -9. 835 -89. 445 1.00 49. 82 A c

ATOM 306 CB ASN A 36 -6. 161 -10. 583 -89. 786 1.00 53. 04 A c

ATOM 309 CG ASN A 36 -4. 923 -9. 688 -89. 702 1.00 56. 29 A c

ATOM 310 ODl ASN A 36 -4. 959 -8. 531 -90. 113 1.00 58. 52 A 0

ATOM 311 ND2 ASN A 36 -3. 823 -10. 226 -89. 164 1.00 56. 41 A N

ATOM 314 C ASN A 36 -8. 683 -10. 790 -89. 559 1.00 51. 64 A c

ATOM 315 O ASN A 36 -8. 595 -11. 852 -90. 189 1.00 54. ,05 A 0

ATOM 317 N GLY A 37 -9. ,803 -10. 414 -88. 939 1.00 48. 62 A N

ATOM 318 CA GLY A 37 -11. ,016 -11. 234 -88. 963 1.00 48. 26 A c

ATOM 321 C GLY A 37 -10. 999 -12. 526 -88. 150 1.00 49. 20 A c

ATOM 322 O GLY A 37 -11. ,911 -13. 348 -88. 283 1.00 49. 81 A 0

ATOM 324 N GLU A 38 -9. 971 -12. 712 -87. 319 1.00 48. 08 A N

ATOM 325 CA GLU A 38 -9. 888 -13. 845 -86. 386 1.00 48. 05 A c

ATOM 327 CB GLU A 38 -8. 557 -14. 599 -86. 540 1.00 53. 92 A c

ATOM 330 CG GLU A 38 -8. 082 -14. 830 -87. 985 1.00 61. 22 A c

ATOM 333 CD GLU A 38 -8. 501 -16. 174 -88. 566 1.00 65. 96 A c

ATOM 334 OEl GLU A 38 -8. ,115 -17. 219 -87. 996 1.00 68. 40 A 0

ATOM 335 OE2 GLU A 38 -9. ,195 -16. 181 -89. 610 1.00 69. 01 A 0

ATOM 336 C GLU A 38 -9. 996 -13. 297 -84. 955 1.00 44. 28 A c

ATOM 337 O GLU A 38 -9. 437 -12. 243 -84. 655 1.00 37. 93 A 0

ATOM 339 N HIS A 39 -10. 693 -14. 028 -84. 079 1.00 42. 52 A N

ATOM 340 CA HIS A 39 -10. 841 -13. 645 -82. 670 1.00 39. 36 A c

ATOM 342 CB HIS A 39 -11. 795 -14. 598 -81. 938 1.00 38. 53 A c

ATOM 345 CG HIS A 39 -11. 840 -14. 375 -80. 457 1.00 36. 59 A c

ATOM 346 NDl HIS A 39 -12. ,725 -13. 504 -79. 863 1.00 33. 32 A N

ATOM 348 CEl HIS A 39 -12. 530 -13. 506 -78. 556 1.00 33. 53 A c

ATOM 350 NE2 HIS A 39 -11. 523 -14. 314 -78. 284 1.00 30. 08 A N

ATOM 352 CD2 HIS A 39 -11. ,079 -14. 877 -79. 455 1.00 34. 04 A C

ATOM 354 C HIS A 39 -9. 509 -13. 623 -81. 928 1.00 34. 93 A C

ATOM 355 O HIS A 39 -8. 760 -14. 587 -81.971 1.00 32. 86 A 0

ATOM 357 N LEU A 40 -9. 243 -12. 522 -81. 222 1.00 34. 95 A N

ATOM 358 CA LEU A 40 -8. 037 -12. 372 -80. 411 1.00 34. 86 A c

ATOM 360 CB LEU A 40 -7. 268 -11. 123 -80. 847 1.00 36. 35 A c

ATOM 363 CG LEU A 40 -5. ,880 -10. 907 -80. ,244 1.00 36. ,45 A c

ATOM 365 CDl LEU A 40 -4. 901 -11. 960 -80. 720 1.00 38. ,29 A c

ATOM 369 CD2 LEU A 40 -5. ,389 -9. 500 -80. 579 1.00 36. ,67 A c

ATOM 373 C LEU A 40 -8. 362 -12. 287 -78. ,914 1.00 32. 92 A c

ATOM 374 O LEU A 40 -7. 854 -13. 063 -78. 127 1.00 34. 56 A 0

ATOM 376 N CYS A 41 -9. 220 -11. 346 -78. 536 1.00 31. 33 A N

ATOM 377 CA CYS A 41 -9. 496 -11. 057 -77. 132 1.00 29. 57 A c

ATOM 379 CB CYS A 41 -8. 747 -9. 785 -76. 708 1.00 34. 23 A c

ATOM 382 SG CYS A 41 -6. ,979 -10. 034 -76. 272 1.00 42. ,24 A S

ATOM 384 C CYS A 41 -10. ,983 -10. 840 -76. 923 1.00 30. ,66 A c

ATOM 385 O CYS A 41 -11. ,738 -10. 652 -77. ,871 1.00 29. ,93 A 0

ATOM 387 N GLY A 42 -11. ,390 -10. 858 -75. ,665 1.00 28. ,56 A N

ATOM 388 CA GLY A 42 -12. 696 -10. 425 -75. ,284 1.00 27. ,04 A c

ATOM 391 C GLY A 42 -12. 698 -8. 924 -75. ,121 1.00 27. 35 A c

ATOM 392 O GLY A 42 -11. ,648 -8. 288 -75. 024 1.00 27. 10 A 0

ATOM 394 N GLY A 43 -13. 903 -8. 375 -75. 099 1.00 23. 78 A N

ATOM 395 CA GLY A 43 -14. 143 -6. 967 -74. 839 1.00 23. ,82 A c

ATOM 398 C GLY A 43 -15. ,529 -6. ,812 -74. 250 1.00 23. ,52 A c

ATOM 399 O GLY A 43 -16. ,335 -7. 748 -74. ,270 1.00 23. ,58 A 0

ATOM 401 N VAL A 44 -15. ,805 -5. 627 -73. ,725 1.00 25. ,38 A N

ATOM 402 CA VAL A 44 -17. ,076 -5. 346 -73. ,084 1.00 26. 23 A c

ATOM 404 CB VAL A 44 -16. ,995 -5. 518 -71. ,536 1.00 26. 22 A c cyno fD_Fab

ATOM 406 CGI VAL A 44 -15.649 -5. 085 -71. .014 1.00 28. 01 A C

ATOM 410 CG2 VAL A 44 -18.118 -4. 788 -70. ,837 1.00 25. 18 A C

ATOM 414 C VAL A 44 -17.525 -3. 952 -73. ,477 1.00 22. 57 A c

ATOM 415 0 VAL A 44 -16.788 -2. 997 -73, ,308 1.00 28. 52 A 0

ATOM 417 N LEU A 45 -18.724 -3. 863 -74. ,046 1.00 25. 78 A N

ATOM 418 CA LEU A 45 -19.339 -2. 579 -74. ,397 1.00 25. 99 A c

ATOM 420 CB LEU A 45 -20.584 -2. 772 -75. ,271 1.00 22. 25 A c

ATOM 423 CG LEU A 45 -21.000 -1. 599 -76. ,172 1.00 23. 74 A c

ATOM 425 CDl LEU A 45 -19.997 -1. 375 -77. ,298 1.00 21. 58 A c

ATOM 429 CD2 LEU A 45 -22.407 -1. 807 -76.751 1.00 21. 88 A c

ATOM 433 C LEU A 45 -19.702 -1. 885 -73. ,103 1.00 27. 07 A c

ATOM 434 0 LEU A 45 -20.500 -2. 394 -72, ,322 1.00 30. 27 A 0

ATOM 436 N VAL A 46 -19.054 -0. 749 -72, ,871 1.00 29. 71 A N

ATOM 437 CA VAL A 46 -19.270 0. 078 -71. ,694 1.00 28. 45 A c

ATOM 439 CB VAL A 46 -17.949 0. 265 -70. ,885 1.00 25. 81 A c

ATOM 441 CGI VAL A 46 -17.675 -0. 969 -70. ,054 1.00 22. 60 A c

ATOM 445 CG2 VAL A 46 -16.779 0. 581 -71, ,798 1.00 20. 30 A c

ATOM 449 C VAL A 46 -19.893 1. 430 -72. ,084 1.00 31. 31 A c

ATOM 450 0 VAL A 46 -20.444 2. 145 -71. ,236 1.00 34. 22 A 0

ATOM 452 N ALA A 47 -19.820 1. 767 -73. 370 1.00 26. 86 A N

ATOM 453 CA ALA A 47 -20.559 2. 899 -73. 921 1.00 30. 42 A c

ATOM 455 CB ALA A 47 -19.698 4. 166 -73. ,907 1.00 29. 60 A c

ATOM 459 C ALA A 47 -20.970 2. 546 -75. ,342 1.00 29. 23 A c

ATOM 460 0 ALA A 47 -20.506 1. 558 -75. ,900 1.00 30. 51 A 0

ATOM 462 N GLU A 48 -21.805 3. 374 -75. ,941 1.00 31. 78 A N

ATOM 463 CA GLU A 48 -22.321 3. 095 -77, ,274 1.00 34. 71 A c

ATOM 465 CB GLU A 48 -23.372 4. 127 -77, ,661 1.00 36. 90 A c

ATOM 468 CG GLU A 48 -24.487 4. 255 -76. ,641 1.00 39. 94 A c

ATOM 471 CD GLU A 48 -25.745 4. 857 -77. ,212 1.00 41. 92 A c

ATOM 472 OEl GLU A 48 -26.812 4. 679 -76. 579 1.00 47. 41 A 0

ATOM 473 OE2 GLU A 48 -25.675 5. 497 -78. 290 1.00 43. 89 A 0

ATOM 474 C GLU A 48 -21.241 3. 019 -78. 355 1.00 32. 33 A c

ATOM 475 0 GLU A 48 -21.418 2. 299 -79. ,328 1.00 33. 60 A 0

ATOM 477 N GLN A 49 -20.142 3. 758 -78. ,186 1.00 35. 25 A N

ATOM 478 CA GLN A 49 -19.029 3. 772 -79. ,153 1.00 36.15 A c

ATOM 480 CB GLN A 49 -18.803 5. 208 -79. ,666 1.00 39. 44 A c

ATOM 483 CG GLN A 49 -17.890 5. 310 -80. ,903 1.00 39. 74 A c

ATOM 486 CD GLN A 49 -18.178 6. 526 -81. ,783 1.00 40. 76 A c

ATOM 487 OEl GLN A 49 -18.921 7. 435 -81. ,401 1.00 46. 06 A 0

ATOM 488 NE2 GLN A 49 -17.585 6. 541 -82. ,971 1.00 40. 57 A N

ATOM 491 C GLN A 49 -17.719 3. 220 -78. ,573 1.00 36. 42 A c

ATOM 492 0 GLN A 49 -16.665 3. 298 -79. ,220 1.00 35. 80 A 0

ATOM 494 N TRP A 50 -17.782 2. 642 -77. ,371 1.00 32. 55 A N

ATOM 495 CA TRP A 50 -16.577 2. 258 -76. ,645 1.00 31.91 A c

ATOM 497 CB TRP A 50 -16.313 3. 260 -75. ,513 1.00 35. 09 A c

ATOM 500 CG TRP A 50 -15.855 4. 611 -76. ,007 1.00 33. ,91 A c

ATOM 501 CDl TRP A 50 -16.624 5. 711 -76. ,197 1.00 35. ,87 A c

ATOM 503 NEl TRP A 50 -15.858 6. 754 -76. ,659 1.00 35. 92 A N

ATOM 505 CE2 TRP A 50 -14.561 6. 332 -76. ,783 1.00 32. ,97 A c

ATOM 506 CD2 TRP A 50 -14.518 4. 987 -76. ,380 1.00 34. ,37 A c

ATOM 507 CE3 TRP A 50 -13.292 4. 313 -76. ,414 1.00 35. ,44 A c

ATOM 509 CZ3 TRP A 50 -12.157 5. 001 -76. ,840 1.00 35. 02 A c

ATOM 511 CH2 TRP A 50 -12.232 6. 345 -77. ,232 1.00 34. 96 A c

ATOM 513 CZ2 TRP A 50 -13.424 7. 024 -77. ,214 1.00 36. ,37 A c

ATOM 515 C TRP A 50 -16.616 0. 831 -76. ,098 1.00 28. 60 A c

ATOM 516 0 TRP A 50 -17.510 0. 468 -75. ,334 1.00 25. 01 A 0

ATOM 518 N VAL A 51 -15.623 0. ,043 -76. .507 1.00 30. ,32 A N

ATOM 519 CA VAL A 51 -15.398 -1. 317 -76. ,027 1.00 28. 53 A c

ATOM 521 CB VAL A 51 -15.270 -2. 297 -77. ,219 1.00 28. 90 A c

ATOM 523 CGI VAL A 51 -14.754 -3. 669 -76. ,767 1.00 28. ,11 A c

ATOM 527 CG2 VAL A 51 -16.590 -2. ,429 -77, ,935 1.00 29. ,99 A c

ATOM 531 C VAL A 51 -14.105 -1. ,363 -75, ,193 1.00 31.96 A c

ATOM 532 0 VAL A 51 -13.021 -0. 994 -75. ,668 1.00 31. 84 A 0

ATOM 534 N LEU A 52 -14.225 -1. 832 -73. ,954 1.00 30. ,30 A N

ATOM 535 CA LEU A 52 -13.083 -1. 973 -73. ,046 1.00 26. ,83 A c

ATOM 537 CB LEU A 52 -13.522 -1. 658 -71, ,600 1.00 24. ,00 A c

ATOM 540 CG LEU A 52 -12.530 -1. 785 -70, ,441 1.00 26. ,30 A c

ATOM 542 CDl LEU A 52 -11.362 -0. 803 -70. ,561 1.00 27. ,73 A c cyno fD_Fab

ATOM 546 CD2 LEU A 52 -13. 244 -1.589 -69. 126 1.00 23. ,19 A C

ATOM 550 C LEU A 52 -12. 512 -3.395 -73. 169 1.00 24. ,16 A C

ATOM 551 O LEU A 52 -13. 255 -4.370 -73. 144 1.00 24. ,61 A 0

ATOM 553 N SE A 53 -11. 196 -3.499 -73. 339 1.00 23. ,00 A N

ATOM 554 CA SER A 53 -10. 508 -4.781 -73. 439 1.00 27. ,04 A C

ATOM 556 CB SER A 53 -10. 277 -5.155 -74. 913 1.00 29. ,06 A c

ATOM 559 OG SER A 53 -9. 612 -6.410 -75. 055 1.00 27. ,09 A 0

ATOM 561 C SER A 53 -9. 198 -4.658 -72. 645 1.00 28. ,69 A c

ATOM 562 O SER A 53 -9. 121 -3.836 -71. 727 1.00 28. ,98 A 0

ATOM 564 N ALA A 54 -8. 190 -5.465 -72. 982 1.00 27. ,47 A N

ATOM 565 CA ALA A 54 -6. 909 -5.478 -72. 266 1.00 31. ,99 A c

ATOM 567 CB ALA A 54 -6. 582 -6.904 -71. 776 1.00 31. ,40 A c

ATOM 571 C ALA A 54 -5. 782 -4.945 -73. 156 1.00 32. ,26 A c

ATOM 572 O ALA A 54 -5. 740 -5.233 -74. 342 1.00 32. ,95 A 0

ATOM 574 N ALA A 55 -4. 875 -4.181 -72. 563 1.00 33. ,82 A N

ATOM 575 CA ALA A 55 -3. 795 -3.495 -73. 283 1.00 39. ,01 A c

ATOM 577 CB ALA A 55 -2. 973 -2.624 -72. 306 1.00 38. ,89 A c

ATOM 581 C ALA A 55 -2. 872 -4.428 -74. 054 1.00 41. ,72 A c

ATOM 582 O ALA A 55 -2. 463 -4.105 -75. 167 1.00 44. 26 A 0

ATOM 584 N HIS A 56 -2. 560 -5.584 -73. 481 1.00 46. 85 A N

ATOM 585 CA HIS A 56 -1. 685 -6.556 -74. 146 1.00 50.67 A c

ATOM 587 CB HIS A 56 -1. 252 -7.649 -73. 162 1.00 55. 55 A c

ATOM 590 CG HIS A 56 0. 047 -8.305 -73. 520 1.00 58. 27 A c

ATOM 591 NDl HIS A 56 1. 241 -7.615 -73. 572 1.00 63. 43 A N

ATOM 593 CEl HIS A 56 2. 212 -8.444 -73. 912 1.00 64. ,94 A c

ATOM 595 NE2 HIS A 56 1. 692 -9.647 -74. 083 1.00 66. 19 A N

ATOM 597 CD2 HIS A 56 0. 340 -9.588 -73. 840 1.00 63. 62 A C

ATOM 599 C HIS A 56 -2. 298 -7.193 -75. 409 1.00 54. 34 A c

ATOM 600 O HIS A 56 -1. 596 -7.865 -76. 159 1.00 58. 13 A 0

ATOM 602 N CYS A 57 -3. 595 -6.990 -75. 643 1.00 55. ,16 A N

ATOM 603 CA CYS A 57 -4. 241 -7.437 -76. 881 1.00 54. ,80 A c

ATOM 605 CB CYS A 57 -5. 763 -7.332 -76. 759 1.00 50. ,85 A c

ATOM 608 SG CYS A 57 -6. 464 -8.304 -75. 389 1.00 48. ,06 A s

ATOM 610 C CYS A 57 -3. 764 -6.628 -78. 088 1.00 56. ,94 A c

ATOM 611 O CYS A 57 -3. 619 -7.170 -79. 177 1.00 57. 62 A 0

ATOM 613 N LEU A 58 -3. 526 -5.334 -77. 883 1.00 61. ,49 A N

ATOM 614 CA LEU A 58 -3. 037 -4.447 -78. 940 1.00 63. ,98 A c

ATOM 616 CB LEU A 58 -3. 175 -2.974 -78. 517 1.00 63. ,85 A c

ATOM 619 CG LEU A 58 -3. 100 -1.892 -79. 606 1.00 62. ,67 A c

ATOM 621 CDl LEU A 58 -4. 287 -1.962 -80. 553 1.00 61. ,45 A c

ATOM 625 CD2 LEU A 58 -3. 016 -0.498 -78. 989 1.00 62. ,87 A c

ATOM 629 C LEU A 58 -1. 584 -4.771 -79. 300 1.00 67. ,51 A c

ATOM 630 0 LEU A 58 -1. 203 -4.674 -80. 465 1.00 66. ,96 A 0

ATOM 632 N GLU A 59 -0. 782 -5.151 -78. 302 1.00 72. ,93 A N

ATOM 633 CA GLU A 59 0. 579 -5.641 -78. 543 1.00 73. ,70 A c

ATOM 635 CB GLU A 59 1. 258 -6.076 -77. 230 1.00 77. ,62 A c

ATOM 638 CG GLU A 59 2. 756 -6.449 -77. 358 1.00 80. ,32 A c

ATOM 641 CD GLU A 59 3. 027 -7.951 -77. ,605 1.00 85. ,48 A c

ATOM 642 OEl GLU A 59 2. 771 -8.772 -76. ,695 1.00 87. ,61 A 0

ATOM 643 OE2 GLU A 59 3. 532 -8.310 -78. 699 1.00 86. ,16 A 0

ATOM 644 C GLU A 59 0. 536 -6.813 -79. 522 1.00 74. ,77 A c

ATOM 645 0 GLU A 59 1. 286 -6.843 -80. 501 1.00 75. ,22 A 0

ATOM 647 N ASP A 60 -0. 357 -7.766 -79. 253 1.00 75. ,45 A N

ATOM 648 CA ASP A 60 -0. 469 -8.988 -80. 057 1.00 75. ,68 A c

ATOM 650 CB ASP A 60 -1. 319 -10.038 -79. 322 1.00 76. ,16 A c

ATOM 653 CG ASP A 60 -0. 607 -10.641 -78. 115 1.00 76. ,05 A c

ATOM 654 ODl ASP A 60 0. 644 -10.628 -78. ,075 1.00 75. ,72 A 0

ATOM 655 002 ASP A 60 -1. 309 -11.145 -77. 208 1.00 75. ,08 A 0

ATOM 656 C ASP A 60 -1. 040 -8.761 -81. 463 1.00 75. ,69 A c

ATOM 657 0 ASP A 60 -0. 778 -9.556 -82. 365 1.00 75. ,69 A 0

ATOM 659 N ALA A 61 -1. 816 -7.691 -81. 641 1.00 76. ,28 A N

ATOM 660 CA ALA A 61 -2. 439 -7.379 -82. 933 1.00 76. ,49 A c

ATOM 662 CB ALA A 61 -3. 544 -6.344 -82. 755 1.00 75. ,75 A c

ATOM 666 C ALA A 61 -1. 411 -6.883 -83. 949 1.00 76. ,14 A c

ATOM 667 0 ALA A 61 -1. 365 -7.368 -85. 081 1.00 73. ,75 A 0

ATOM 669 N ALA A 62 -0. 608 -5.902 -83. ,532 1.00 77. ,09 A N

ATOM 670 CA ALA A 62 0. 530 -5.407 -84. ,312 1.00 77. ,12 A c

ATOM 672 CB ALA A 62 1. 572 -6.530 -84. ,484 1.00 77. ,94 A c cyno fD_Fab

ATOM 676 C ALA A 62 0. ,123 -4. ,804 -85. 673 1.00 76. ,63 A C

ATOM 677 O ALA A 62 -0. ,594 -3. 798 -85. ,721 1.00 73. ,71 A 0

ATOM 679 N ASF* A 63 0. 594 -5 . 421 -86. ,761 1.00 77. ,20 A N

ATOM 680 CA ASP A 63 0. 269 -5 . 013 -88 . ,139 1.00 76. ,00 A C

ATOM 682 CB ASP A 63 0. 908 -5. 990 -89. ,156 1.00 77. ,15 A C

ATOM 685 CG ASP A 63 2. 265 -5. 526 -89. ,684 1.00 77. ,04 A c

ATOM 686 ODl ASP A 63 2. ,773 -4. 472 -89. ,245 1.00 77 . 86 A 0

ATOM 687 OD2 ASP A 63 2. 820 -6. 233 -90. ,559 1.00 73. ,97 A 0

ATOM 688 C ASP A 63 -1. 236 -4. 991 -88 . ,413 1.00 75. ,62 A c

ATOM 689 O ASP A 63 -1. 755 -4. 016 -88 . ,961 1.00 76. ,42 A 0

ATOM 691 N GLY A 64 -1. 915 -6. 073 -88 . ,027 1.00 72. ,42 A N

ATOM 692 CA GLY A 64 -3 . 268 -6. 381 -88. ,494 1.00 68. ,45 A C

ATOM 695 C GLY A 64 -4. 340 -5. 332 -88. 269 1.00 65. ,09 A C

ATOM 696 O GLY A 64 -4. 184 -4. 421 -87. ,454 1.00 64. ,75 A 0

ATOM 698 N LYS A 65 -5 . 438 -5. 472 -89. ,008 1.00 62. ,79 A N

ATOM 699 CA LYS A 65 -6. 588 -4. 584 -88. 871 1.00 60. 89 A C

ATOM 701 CB LYS A 65 -7. 456 -4. 631 -90. 132 1.00 61. ,99 A C

ATOM 704 CG LYS A 65 -8. 527 -3. 555 -90. ,177 1.00 62. ,81 A c

ATOM 707 CD LYS A 65 -9. 269 -3. 566 -91. ,498 1.00 63. ,38 A c

ATOM 710 CE LYS A 65 -10. 248 -2. 409 -91. ,581 1.00 63. ,79 A c

ATOM 713 NZ LYS A 65 -11. 198 -2. 584 -92. ,720 1.00 63. ,77 A N

ATOM 717 C LYS A 65 -7. 399 -5 . 025 -87. ,661 1.00 56. ,68 A c

ATOM 718 O LYS A 65 -7. 799 -6. 184 -87. ,584 1.00 55 . ,16 A 0

ATOM 720 N VAL A 66 -7. 626 -4. 109 -86. ,719 1.00 52. , 66 A N

ATOM 721 CA VAL A 66 -8. 365 -4. 417 -85. 493 1.00 50. ,12 A c

ATOM 723 CB VAL A 66 -7. 790 -3. 679 -84. 268 1.00 48. 86 A c

ATOM 725 CGI VAL A 66 -8 . 685 -3. 877 -83. 052 1.00 47. ,57 A c

ATOM 729 CG2 VAL A 66 -6. 391 -4. 170 -83. 975 1.00 51.58 A c

ATOM 733 C VAL A 66 -9. 836 -4. 054 -85. ,644 1.00 47. ,37 A c

ATOM 734 O VAL A 66 -10. 172 -2. 905 -85. 937 1.00 49. , 77 A 0

ATOM 736 N GLN A 67 -10. 706 -5 . 040 -85. 434 1.00 43. 89 A N

ATOM 737 CA GLN A 67 -12. 151 -4. 857 -85. ,547 1.00 41. ,12 A c

ATOM 739 CB GLN A 67 -12. 653 -5. 535 -86. 823 1.00 40. 24 A c

ATOM 742 CG GLN A 67 -12. 229 -4. 824 -88. 105 1.00 39. ,41 A c

ATOM 745 CD GLN A 67 -12. 375 -5. 688 -89. 340 1.00 38. 04 A c

ATOM 746 OEl GLN A 67 -11. 856 -6. 804 -89. 404 1.00 33. 96 A 0

ATOM 747 NE2 GLN A 67 -13. 062 -5. 165 -90. 341 1.00 37. ,16 A N

ATOM 750 C GLN A 67 -12. 855 -5. 444 -84. 320 1.00 40. ,02 A c

ATOM 751 O GLN A 67 -12. 290 -6. 294 -83. 626 1.00 38. ,85 A 0

ATOM 753 N VAL A 68 -14. 082 -4. 993 -84. ,057 1.00 38. ,42 A N

ATOM 754 CA VAL A 68 -14. 861 -5. 479 -82. 901 1.00 36. 89 A c

ATOM 756 CB VAL A 68 -15. 053 -4. 360 -81. 848 1.00 36. 68 A c

ATOM 758 CGI VAL A 68 -15. 926 -4. 842 -80. 676 1.00 35. ,81 A c

ATOM 762 CG2 VAL A 68 -13. 706 -3 . 879 -81. 361 1.00 29. ,48 A c

ATOM 766 C VAL A 68 -16. 221 -6. 036 -83. 337 1.00 33 . ,30 A c

ATOM 767 O VAL A 68 -17. 039 -5 . 314 -83. ,896 1.00 32. ,49 A 0

ATOM 769 N LEU A 69 -16. 457 -7. 319 -83. ,072 1.00 30. ,19 A N

ATOM 770 CA LEU A 69 -17. 730 -7. 963 -83. 404 1.00 27. ,71 A c

ATOM 772 CB LEU A 69 -17. 494 -9. ,401 -83. 869 1.00 25. ,35 A c

ATOM 775 CG LEU A 69 -18. 683 -10. 245 -84. ,345 1.00 23. ,87 A c

ATOM 777 CDl LEU A 69 -19. 164 -9. ,828 -85. ,733 1.00 23. 88 A c

ATOM 781 CD2 LEU A 69 -18. 311 -11. ,713 -84. ,323 1.00 21. ,58 A c

ATOM 785 C LEU A 69 -18. 665 -7. ,929 -82. ,195 1.00 29. 88 A c

ATOM 786 O LEU A 69 -18. 354 -8. 494 -81. ,139 1.00 32. ,08 A 0

ATOM 788 N LEU A 70 -19. 799 -7. 247 -82. ,357 1.00 27. ,53 A N

ATOM 789 CA LEU A 70 -20. 838 -7. 169 -81. ,328 1.00 24. ,29 A C

ATOM 791 CB LEU A 70 -21. 274 -5 . 717 -81. 111 1.00 23. ,26 A c

ATOM 794 CG LEU A 70 -20. 190 -4. 756 -80. ,600 1.00 20. ,72 A c

ATOM 796 CDl LEU A 70 -20. 678 -3. 308 -80. 577 1.00 20. ,49 A c

ATOM 800 CD2 LEU A 70 -19. 731 -5 . 156 -79. 221 1.00 18. ,03 A c

ATOM 804 C LEU A 70 -22. 019 -8. ,019 -81. ,766 1.00 18. ,72 A c

ATOM 805 O LEU A 70 -22. 135 -8 . ,354 -82. ,939 1.00 21. ,17 A 0

ATOM 807 N GLY A 71 -22. 896 -8. 376 -80. ,832 1.00 21. ,94 A N

ATOM 808 CA GLY A 71 -24. 111 -9. 145 -81. ,159 1.00 19. ,69 A c

ATOM 811 C GLY A 71 -23. 886 -10. ,595 -81. ,578 1.00 24. ,27 A c

ATOM 812 O GLY A 71 -24. 783 -11.226 -82. ,140 1.00 27. ,07 A 0

ATOM 814 N ALA A 72 -22. 692 -11. 114 -81. ,285 1.00 21. ,12 A N

ATOM 815 CA ALA A 72 -22. 256 -12. 439 -81. ,693 1.00 21. ,42 A c cyno fD_Fab

ATOM 817 CB ALA A 72 -20. .715 -12, .424 -81. .957 1.00 18. ,29 A C

ATOM 821 C ALA A 72 -22. .580 -13, .513 -80. ,657 1.00 19. ,25 A C

ATOM 822 O ALA A 72 -22, .527 -13, .278 -79. .443 1.00 17. ,21 A 0

ATOM 824 N HIS A 73 -22, .914 -14, .703 -81. ,141 1.00 18. ,03 A N

ATOM 825 CA HIS A 73 -22, ,806 -15, .879 -80. .315 1.00 19. 39 A C

ATOM 827 CB HIS A 73 -24, .160 -16, .519 -80. ,066 1.00 17. 50 A C

ATOM 830 CG HIS A 73 -24. .085 -17, .651 -79. ,102 1.00 14. 96 A c

ATOM 831 NDl HIS A 73 -23. .529 -17, .505 -77. ,854 1.00 14. ,20 A N

ATOM 833 CEl HIS A 73 -23. .566 -18, .663 -77. ,220 1.00 14. 22 A c

ATOM 835 NE2 HIS A 73 -24. ,116 -19, .557 -78. ,018 1.00 13. 69 A N

ATOM 837 CD2 HIS A 73 -24. ,435 -18, .954 -79. ,212 1.00 15. 47 A c

ATOM 839 C HIS A 73 -21.825 -16, .847 -80. ,977 1.00 23. 60 A c

ATOM 840 O HIS A 73 -20. ,769 -17, .121 -80. ,426 1.00 20. 57 A 0

ATOM 842 N SER A 74 -22, ,180 -17, .337 -82. ,167 1.00 27. 98 A N

ATOM 843 CA SER A 74 -21. ,254 -18, ,049 -83. ,042 1.00 27. 19 A c

ATOM 845 CB SER A 74 -22. ,020 -18, .819 -84. ,118 1.00 30. 31 A c

ATOM 848 OG SER A 74 -21. ,143 -19, .209 -85. ,162 1.00 29. 56 A 0

ATOM 850 C SER A 74 -20. ,331 -17, .065 -83. ,746 1.00 28. 34 A c

ATOM 851 O SER A 74 -20. ,808 -16, ,104 -84. ,340 1.00 29. 97 A 0

ATOM 853 N LEU A 75 -19. ,024 -17. .310 -83. ,698 1.00 28. 45 A N

ATOM 854 CA LEU A 75 -18. ,066 -16. ,486 -84. ,438 1.00 30. 77 A c

ATOM 856 CB LEU A 75 -16. 633 -16. .743 -83. ,962 1.00 31. 45 A c

ATOM 859 CG LEU A 75 -16. ,204 -16. .437 -82. ,519 1.00 29. 83 A c

ATOM 861 CDl LEU A 75 -14. ,760 -16. .923 -82. ,318 1.00 27. 82 A c

ATOM 865 CD2 LEU A 75 -16. ,323 -14. ,955 -82. ,194 1.00 24. 98 A c

ATOM 869 C LEU A 75 -18. ,160 -16. .749 -85. ,958 1.00 31.94 A c

ATOM 870 O LEU A 75 -18. ,016 -15. ,821 -86. ,755 1.00 31. 39 A 0

ATOM 872 N SER A 76 -18. ,417 -17. ,997 -86. ,357 1.00 29. 54 A N

ATOM 873 CA SER A 76 -18. ,378 -18. ,363 -87. ,782 1.00 33. 60 A c

ATOM 875 CB SER A 76 -17. 793 -19. ,769 -87. ,972 1.00 32. 67 A c

ATOM 878 OG SER A 76 -18. ,645 -20. ,773 -87. 455 1.00 34. 34 A 0

ATOM 880 C SER A 76 -19. ,706 -18. ,232 -88. 549 1.00 35. 72 A c

ATOM 881 O SER A 76 -19. 688 -17. ,883 -89. 729 1.00 36. 76 A 0

ATOM 883 N GLN A 77 -20. 837 -18. ,516 -87. 894 1.00 38. 21 A N

ATOM 884 CA GLN A 77 -22. 164 -18. ,483 -88. 544 1.00 36. 54 A c

ATOM 886 CB GLN A 77 -23. 120 -19. ,466 -87. 862 1.00 42. 31 A c

ATOM 889 CG GLN A 77 -22. 664 -20. ,908 -87. 880 1.00 47. 30 A c

ATOM 892 CD GLN A 77 -22. 391 -21. ,412 -89. 292 1.00 53. 49 A c

ATOM 893 OEl GLN A 77 -21. 298 -21. ,212 -89. 829 1.00 56. 37 A 0

ATOM 894 NE2 GLN A 77 -23. 384 -22. ,070 -89. 898 1.00 53. 31 A N

ATOM 897 C GLN A 77 -22. 807 -17. ,090 -88. 531 1.00 33. 29 A c

ATOM 898 O GLN A 77 -22. 959 -16. ,485 -87. 464 1.00 24. 82 A 0

ATOM 900 N PRO A 78 -23. 209 -16. ,581 -89. 716 1.00 34. 78 A N

ATOM 901 CA PRO A 78 -23. 772 -15. 233 -89. 792 1.00 35. 05 A c

ATOM 903 CB PRO A 78 -23. 708 -14. 915 -91. 285 1.00 37. 90 A c

ATOM 906 CG PRO A 78 -23. 858 -16. 236 -91. 940 1.00 37. 29 A c

ATOM 909 CD PRO A 78 -23. 179 -17. 230 -91. 041 1.00 36. 88 A c

ATOM 912 C PRO A 78 -25. 212 -15. 172 -89. 286 1.00 33. 48 A c

ATOM 913 O PRO A 78 -25. 929 -16. ,178 -89. 296 1.00 31. 67 A 0

ATOM 914 N GLU A 79 -25. 624 -13. 973 -88. 890 1.00 34. 04 A N

ATOM 915 CA GLU A 79 -26. 791 -13. 772 -88. 039 1.00 31. 69 A c

ATOM 917 CB GLU A 79 -26. 397 -14. 079 -86. 581 1.00 34. 44 A c

ATOM 920 CG GLU A 79 -27. 420 -14. 847 -85. 795 1.00 33. 26 A c

ATOM 923 CD GLU A 79 -27. 183 -14. ,794 -84. 297 1.00 28. 32 A c

ATOM 924 OEl GLU A 79 -26. 028 -14. 815 -83. 842 1.00 26. 80 A 0

ATOM 925 OE2 GLU A 79 -28. 180 -14. 750 -83. 557 1.00 29. 16 A 0

ATOM 926 C GLU A 79 -27. 154 -12. 294 -88. 148 1.00 28. 59 A c

ATOM 927 O GLU A 79 -26. 253 -11. 465 -88. 192 1.00 29. 20 A 0

ATOM 929 N PRO A 80 -28. 457 -11. 952 -88. 207 1.00 28. 86 A N

ATOM 930 CA PRO A 80 -28. 864 -10. 540 -88. 231 1.00 29. 72 A c

ATOM 932 CB PRO A 80 -30. 392 -10. 606 -88. 113 1.00 31. 62 A c

ATOM 935 CG PRO A 80 -30. 766 -11. 930 -88. 610 1.00 30. 48 A c

ATOM 938 CD PRO A 80 -29. 612 -12. 857 -88. 334 1.00 29. 51 A c

ATOM 941 C PRO A 80 -28. 275 -9. 664 -87. 107 1.00 30. 10 A c

ATOM 942 O PRO A 80 -27. 980 -8. 491 -87. 341 1.00 28. 03 A 0

ATOM 943 N SER A 81 -28. 097 -10. 220 -85. 910 1.00 29. 80 A N

ATOM 944 CA SER A 81 -27. 549 -9. 448 -84. 786 1.00 29. 46 A c

ATOM 946 CB SER A 81 -27. 917 -10. 110 -83. 456 1.00 28. 08 A c cyno fD_Fab

ATOM 949 OG SER A 81 -27. .360 -11. ,408 -83. ,351 1.00 27. ,56 A 0

ATOM 951 C SER A 81 -26, .028 -9. 218 -84. 866 1.00 26. ,31 A C

ATOM 952 0 SER A 81 -25, .519 -8. 260 -84. 296 1.00 27. ,29 A 0

ATOM 954 N LYS A 82 -25, .314 -10. 085 -85. 570 1.00 28. 76 A N

ATOM 955 CA LYS A 82 -23, .846 -10. 022 -85. 649 1.00 31. 99 A C

ATOM 957 CB LYS A 82 -23, .313 -11. ,334 -86. 249 1.00 31.86 A C

ATOM 960 CG LYS A 82 -22. ,039 -11. 870 -85. 642 1.00 34. 31 A c

ATOM 963 CD LYS A 82 -21. .835 -13. 365 -85. 945 1.00 34. 80 A c

ATOM 966 CE LYS A 82 -20.837 -13. 589 -87. 054 1.00 36. 31 A c

ATOM 969 NZ LYS A 82 -20, .696 -15. 025 -87. ,392 1.00 36. ,18 A N

ATOM 973 C LYS A 82 -23, .402 -8. ,827 -86. ,511 1.00 34. ,03 A c

ATOM 974 0 LYS A 82 -23, .667 -8. 805 -87. ,713 1.00 37. 75 A 0

ATOM 976 N ARG A 83 -22, ,751 -7. 834 -85. 903 1.00 36. ,11 A N

ATOM 977 CA ARG A 83 -22, .193 -6. 695 -86. 653 1.00 35. 90 A c

ATOM 979 CB ARG A 83 -23, .036 -5. 429 -86. ,460 1.00 39. ,71 A c

ATOM 982 CG ARG A 83 -24. ,048 -5. 160 -87. 590 1.00 46. 39 A c

ATOM 985 CD ARG A 83 -24. ,158 -3. 665 -87. 920 1.00 48. 90 A c

ATOM 988 NE ARG A 83 -22. ,872 -3. 087 -88. 348 1.00 51. 39 A N

ATOM 990 CZ ARG A 83 -22. ,622 -1. 778 -88. 470 1.00 51. 65 A c

ATOM 991 NHl ARG A 83 -23. ,570 -0. 875 -88. 204 1.00 52. 51 A N

ATOM 994 NH2 ARG A 83 -21. ,415 -1. 364 -88. 861 1.00 51. 45 A N

ATOM 997 C ARG A 83 -20, ,739 -6. 417 -86. ,280 1.00 35. ,72 A C

ATOM 998 0 ARG A 83 -20, .405 -6. 247 -85. 099 1.00 34. 99 A 0

ATOM 1000 N LEU A 84 -19. .887 -6. 357 -87. 306 1.00 32. 54 A N

ATOM 1001 CA LEU A 84 -18. ,453 -6. 130 -87. ,151 1.00 30. 78 A C

ATOM 1003 CB LEU A 84 -17. ,695 -6. 991 -88. ,171 1.00 31. ,81 A C

ATOM 1006 CG LEU A 84 -16. ,171 -7. 155 -88. 050 1.00 33. 03 A C

ATOM 1008 CDl LEU A 84 -15. ,737 -7. 757 -86. 713 1.00 30. 89 A c

ATOM 1012 CD2 LEU A 84 -15. ,645 -8. 008 -89. 209 1.00 32. 32 A c

ATOM 1016 C LEU A 84 -18. ,115 -4. 652 -87. 354 1.00 30. 26 A c

ATOM 1017 0 LEU A 84 -18. ,385 -4. 091 -88. 410 1.00 28. 72 A 0

ATOM 1019 N TYR A 85 -17. ,514 -4. 027 -86. 344 1.00 31. 48 A N

ATOM 1020 CA TYR A 85 -17. ,125 -2. 616 -86. ,411 1.00 33. 56 A c

ATOM 1022 CB TYR A 85 -17. ,554 -1. 907 -85. 126 1.00 32. ,12 A c

ATOM 1025 CG TYR A 85 -19. .044 -1. 850 -84. 969 1.00 30. 23 A c

ATOM 1026 CDl TYR A 85 -19. ,748 -0. 716 -85. 313 1.00 30. 29 A c

ATOM 1028 CEl TYR A 85 -21.128 -0. 666 -85. 192 1.00 30. 75 A c

ATOM 1030 CZ TYR A 85 -21. ,820 -1. 769 -84. 738 1.00 30. 57 A c

ATOM 1031 OH TYR A 85 -23. ,193 -1. 719 -84. 615 1.00 30. 61 A 0

ATOM 1033 CE2 TYR A 85 -21. ,139 -2. 918 -84. 396 1.00 32. 36 A c

ATOM 1035 CD2 TYR A 85 -19. ,757 -2. 959 -84. 525 1.00 32. ,01 A c

ATOM 1037 C TYR A 85 -15. ,623 -2. 408 -86. 625 1.00 35. ,71 A c

ATOM 1038 0 TYR A 85 -14, ,810 -3. 033 -85. 957 1.00 40. 39 A 0

ATOM 1040 N ASP A 86 -15. ,261 -1. 529 -87. 559 1.00 37. 12 A N

ATOM 1041 CA ASP A 86 -13. ,891 -1. 038 -87. 656 1.00 39. 01 A c

ATOM 1043 CB ASP A 86 -13, .711 -0. 081 -88. ,844 1.00 43. ,54 A c

ATOM 1046 CG ASP A 86 -13. .706 -0. 786 -90. ,190 1.00 46. ,52 A c

ATOM 1047 ODl ASP A 86 -13. .393 -1. 990 -90. 249 1.00 49. ,78 A 0

ATOM 1048 OD2 ASP A 86 -14. ,010 -0. 114 -91. ,202 1.00 49. ,20 A 0

ATOM 1049 C ASP A 86 -13. ,588 -0. 278 -86. ,374 1.00 37. ,64 A c

ATOM 1050 0 ASP A 86 -14. ,498 0. 208 -85. ,704 1.00 34. ,63 A 0

ATOM 1052 N VAL A 87 -12. ,311 -0. 177 -86. 033 1.00 40. ,80 A N

ATOM 1053 CA VAL A 87 -11. ,902 0. 599 -84. 866 1.00 44. ,99 A c

ATOM 1055 CB VAL A 87 -10. ,882 -0. 167 -83. 970 1.00 42. ,23 A c

ATOM 1057 CGI VAL A 87 -10. ,503 0. 666 -82. 763 1.00 40. ,88 A c

ATOM 1061 CG2 VAL A 87 -11. ,468 -1. 492 -83. 519 1.00 38. 86 A c

ATOM 1065 C VAL A 87 -11. ,335 1. 929 -85. 359 1.00 47. ,96 A c

ATOM 1066 0 VAL A 87 -10, ,486 1. 966 -86. ,250 1.00 49. ,36 A 0

ATOM 1068 N LEU A 88 -11. .835 3. 013 -84. ,778 1.00 49. ,32 A N

ATOM 1069 CA LEU A 88 -11. .429 4. 365 -85. ,144 1.00 49. ,07 A c

ATOM 1071 CB LEU A 88 -12. ,564 5. 341 -84. ,808 1.00 48. ,00 A c

ATOM 1074 CG LEU A 88 -12. ,704 6. 593 -85. ,661 1.00 49. ,32 A c

ATOM 1076 CDl LEU A 88 -13. ,022 6. 192 -87. ,095 1.00 51. ,05 A c

ATOM 1080 CD2 LEU A 88 -13. ,789 7. 503 -85. ,083 1.00 48. ,37 A c

ATOM 1084 C LEU A 88 -10. ,152 4. 783 -84. ,409 1.00 50. ,71 A c

ATOM 1085 0 LEU A 88 -9. ,356 5. 555 -84. ,935 1.00 51. ,19 A 0

ATOM 1087 N ARG A 89 -9. ,964 4. 260 -83. 198 1.00 51. ,10 A N

ATOM 1088 CA ARG A 89 -8. ,948 4. 758 -82. 277 1.00 50. ,72 A c cyno fD_Fab

ATOM 1090 CB ARG A 89 -9.382 6. 131 -81. 756 1.00 50. ,65 A C

ATOM 1093 CG ARG A 89 -8. 366 6. 859 -80. 898 1.00 52. ,53 A C

ATOM 1096 CD ARG A 89 -8. 915 8. 215 -80. 467 1.00 53. 64 A c

ATOM 1099 NE ARG A 89 -8. 440 8. 611 -79. 137 1.00 53. 72 A N

ATOM 1101 CZ ARG A 89 -9. 161 9. 287 -78. 238 1.00 56. 82 A c

ATOM 1102 NHl ARG A 89 -10. 419 9. 657 -78. 494 1.00 57. 09 A N

ATOM 1105 NH2 ARG A 89 -8. 625 9. 590 -77. 058 1.00 57. 04 A N

ATOM 1108 c ARG A 89 -8. 785 3. 780 -81. 113 1.00 50. 20 A C

ATOM 1109 0 ARG A 89 -9. 751 3. 495 -80. 406 1.00 50. 71 A 0

ATOM 1111 N ALA A 90 -7. 569 3. 265 -80. 929 1.00 49. 57 A N

ATOM 1112 CA ALA A 90 -7. 257 2. 338 -79. 838 1.00 49. 24 A C

ATOM 1114 CB ALA A 90 -6. 502 1. 125 -80. 363 1.00 46. 55 A C

ATOM 1118 C ALA A 90 -6. 430 3. 060 -78. 783 1.00 50. 35 A c

ATOM 1119 O ALA A 90 -5. 315 3. 498 -79. 066 1.00 52. 23 A 0

ATOM 1121 N VAL A 91 -6. 981 3. 177 -77. 576 1.00 49. 71 A N

ATOM 1122 CA VAL A 91 -6. 354 3. 915 -76. 477 1.00 49. 97 A c

ATOM 1124 CB VAL A 91 -7. 309 4. 986 -75. 923 1.00 49. 35 A c

ATOM 1126 CGI VAL A 91 -6. 682 5. 703 -74. 731 1.00 51. 15 A c

ATOM 1130 CG2 VAL A 91 -7. 667 5. 975 -77. 007 1.00 50. 24 A c

ATOM 1134 C VAL A 91 -5. 951 2. 971 -75. 333 1.00 51. 95 A c

ATOM 1135 O VAL A 91 -6. 758 2. 682 -74. 444 1.00 52. 56 A 0

ATOM 1137 N PRO A 92 -4. 695 2. 493 -75. 345 1.00 51. 64 A N

ATOM 1138 CA PRO A 92 -4. 222 1. 723 -74. 204 1.00 52. 99 A c

ATOM 1140 CB PRO A 92 -2. 979 0. 998 -74. 734 1.00 52. 11 A c

ATOM 1143 CG PRO A 92 -2. 627 1. 638 -76. 025 1.00 52. 10 A c

ATOM 1146 CD PRO A 92 -3. 661 2. 655 -76. 379 1.00 52. 98 A c

ATOM 1149 C PRO A 92 -3. 862 2. 645 -73. 052 1.00 52. 72 A c

ATOM 1150 O PRO A 92 -3. 583 3. 824 -73. 268 1.00 53. 28 A 0

ATOM 1151 N HIS A 93 -3. 885 2. 103 -71. 840 1.00 53. 09 A N

ATOM 1152 CA HIS A 93 -3. 578 2. 877 -70. 642 1.00 53. 98 A c

ATOM 1154 CB HIS A 93 -3. 810 2. 022 -69. 395 1.00 48. 30 A c

ATOM 1157 CG HIS A 93 -3. 772 2. 786 -68. 111 1.00 45. 32 A c

ATOM 1158 NDl HIS A 93 -2. 597 3. 071 -67. 452 1.00 43. 04 A N

ATOM 1160 CEl HIS A 93 -2. 868 3. 740 -66. 345 1.00 44. 41 A c

ATOM 1162 NE2 HIS A 93 -4. 176 3. 888 -66. 259 1.00 42. 15 A N

ATOM 1164 CD2 HIS A 93 -4. 765 3. 291 -67. 345 1.00 41. 55 A c

ATOM 1166 C HIS A 93 -2. 118 3. 318 -70. 739 1.00 56. 94 A c

ATOM 1167 0 HIS A 93 -1. 252 2. 499 -71. 078 1.00 58. 81 A 0

ATOM 1169 N PRO A 94 -1. 836 4. 606 -70. 466 1.00 56. 52 A N

ATOM 1170 CA PRO A 94 -0. 479 5. 125 -70.687 1.00 58. 36 A c

ATOM 1172 CB PRO A 94 -0. 606 6. 608 -70. 315 1.00 58. 02 A c

ATOM 1175 CG PRO A 94 -1. 803 6. 683 -69. ,422 1.00 57. 43 A c

ATOM 1178 CD PRO A 94 -2. 740 5. 641 -69. 934 1.00 57. 10 A c

ATOM 1181 C PRO A 94 0. 606 4. 428 -69. 846 1.00 60. 01 A c

ATOM 1182 0 PRO A 94 1. 724 4. 259 -70. 324 1.00 60. 54 A 0

ATOM 1183 N ASP A 95 0. 263 4. 015 -68. 624 1.00 62. 08 A N

ATOM 1184 CA ASP A 95 1. 191 3. 309 -67. 720 1.00 62. 53 A c

ATOM 1186 CB ASP A 95 0. 727 3. 457 -66. 267 1.00 63. 52 A c

ATOM 1189 CG ASP A 95 0. 647 4. 896 -65. ,822 1.00 65. 42 A c

ATOM 1190 ODl ASP A 95 1. 228 5. ,768 -66. ,504 1.00 67. 58 A 0

ATOM 1191 OD2 ASP A 95 0. 003 5. ,153 -64. ,781 1.00 66. ,41 A 0

ATOM 1192 C ASP A 95 1. 373 1. 812 -67. ,999 1.00 63. 25 A c

ATOM 1193 0 ASP A 95 2. 183 1. 155 -67. 332 1.00 62. 76 A 0

ATOM 1195 N SER A 96 0. 627 1. 258 -68. ,956 1.00 64. 83 A N

ATOM 1196 CA SER A 96 0. 753 -0. 166 -69. ,281 1.00 66. 29 A C

ATOM 1198 CB SER A 96 -0. 482 -0. 672 -70. 043 1.00 62. 90 A C

ATOM 1201 OG SER A 96 -0. 628 -0. 043 -71. 302 1.00 61.79 A 0

ATOM 1203 C SER A 96 2. 042 -0. 437 -70. 075 1.00 68. 26 A c

ATOM 1204 0 SER A 96 2. 429 0. 359 -70. 937 1.00 63. 88 A 0

ATOM 1206 N ARG A 97 2. 699 -1. ,558 -69. ,764 1.00 72. ,27 A N

ATOM 1207 CA ARG A 97 3. 952 -1. 969 -70. ,423 1.00 74. 38 A c

ATOM 1209 CB ARG A 97 5. 156 -1. 770 -69. ,487 1.00 77. ,10 A c

ATOM 1212 CG ARG A 97 5. 380 -0. 339 -69. 008 1.00 77. 88 A c

ATOM 1215 CD ARG A 97 5. 821 0. 579 -70. 136 1.00 79. ,38 A c

ATOM 1218 NE ARG A 97 6. 346 1. 853 -69. 639 1.00 80. 35 A N

ATOM 1220 CZ ARG A 97 5. 613 2. 918 -69. ,301 1.00 81. 92 A c

ATOM 1221 NHl ARG A 97 4. 288 2. 902 -69. ,392 1.00 81. ,67 A N

ATOM 1224 NH2 ARG A 97 6. 214 4. 022 -68. ,863 1.00 81. 70 A N cyno fD_Fab

ATOM 1227 C ARG A 97 3. 879 -3. 445 -70. ,852 1.00 74. ,40 A C

ATOM 1228 0 ARG A 97 3. 112 -4. 218 -70. ,276 1.00 72. ,19 A 0

ATOM 1230 N PRO A 98 4. 677 -3. 840 -71.866 1.00 76. ,17 A N

ATOM 1231 CA PRO A 98 4. 718 -5. 262 -72. ,247 1.00 77. ,02 A C

ATOM 1233 CB PRO A 98 5. 470 -5. 257 -73. ,595 1.00 78. ,10 A c

ATOM 1236 CG PRO A 98 5. 623 -3. 810 -73. ,985 1.00 77, .58 A c

ATOM 1239 CD PRO A 98 5. 560 -3. 022 -72. ,717 1.00 77. ,08 A c

ATOM 1242 C PRO A 98 5. 439 -6. 158 -71. ,218 1.00 78. .07 A c

ATOM 1243 0 PRO A 98 5. 250 -7. 382 -71. ,224 1.00 79. ,43 A 0

ATOM 1244 N ASP A 99 6. 257 -5. 545 -70. ,360 1.00 76. ,69 A N

ATOM 1245 CA ASP A 99 6. 940 -6. 242 -69. ,266 1.00 74. ,04 A c

ATOM 1247 CB ASP A 99 8. 065 -5. 363 -68. ,690 1.00 76. ,85 A c

ATOM 1250 CG ASP A 99 9. 188 -5. 104 -69. ,679 1.00 79. ,71 A c

ATOM 1251 ODl ASP A 99 9. 837 -4. 042 -69. ,563 1.00 81. ,00 A 0

ATOM 1252 OD2 ASP A 99 9. 434 -5. 954 -70. ,561 1.00 81. .15 A 0

ATOM 1253 C ASP A 99 5. 988 -6. 593 -68. ,122 1.00 70.17 A c

ATOM 1254 0 ASP A 99 6. 178 -7. 595 -67. ,439 1.00 67. ,81 A 0

ATOM 1256 N THR A 100 4. 978 -5. 749 -67. 920 1.00 68. ,33 A N

ATOM 1257 CA THR A 100 4. 125 -5. 773 -66. 729 1.00 64. ,26 A c

ATOM 1259 CB THR A 100 3. 947 -4. 320 -66. 182 1.00 65. ,15 A c

ATOM 1261 OG1 THR A 100 3. 445 -4. 353 -64. 842 1.00 68. ,86 A 0

ATOM 1263 CG2 THR A 100 2. 999 -3. 506 -67. ,057 1.00 63. ,75 A c

ATOM 1267 C THR A 100 2. 747 -6. 396 -67. Oil 1.00 57. ,71 A c

ATOM 1268 0 THR A 100 2. 383 -6. 608 -68. ,165 1.00 53. ,45 A 0

ATOM 1270 N ILE A 101 2. 006 -6. 712 -65. ,948 1.00 52. .89 A N

ATOM 1271 CA ILE A 101 0. 562 -7. 006 -66. ,054 1.00 54. ,39 A c

ATOM 1273 CB ILE A 101 0. 146 -8. 413 -65. ,461 1.00 52. ,40 A c

ATOM 1275 CGl ILE A 101 0. 566 -8. 569 -63. ,995 1.00 51. ,46 A c

ATOM 1278 CDl ILE A 101 -0. 148 -9. 693 -63. 294 1.00 50. ,97 A c

ATOM 1282 CG2 ILE A 101 0. 709 -9. 544 -66. ,308 1.00 52. ,28 A c

ATOM 1286 C ILE A 101 -0. 288 -5. 884 -65. ,418 1.00 48. ,00 A c

ATOM 1287 0 ILE A 101 -1. 504 -6. 005 -65. 329 1.00 45. ,48 A 0

ATOM 1289 N ASP A 102 0. 360 -4. 798 -64. ,996 1.00 49. ,06 A N

ATOM 1290 CA ASP A 102 -0. 340 -3. 634 -64. ,428 1.00 48. .35 A c

ATOM 1292 CB ASP A 102 0. 607 -2. 799 -63. ,556 1.00 49. ,50 A c

ATOM 1295 CG ASP A 102 1. 128 -3. 559 -62. ,340 1.00 48. .75 A c

ATOM 1296 ODl ASP A 102 0. 331 -3. 907 -61. ,445 1.00 49. ,85 A 0

ATOM 1297 002 ASP A 102 2. 352 -3. 771 -62. ,263 1.00 49. ,93 A 0

ATOM 1298 C ASP A 102 -0. 948 -2. 731 -65. ,515 1.00 46. ,52 A c

ATOM 1299 0 ASP A 102 -0. 437 -2. 644 -66. ,649 1.00 42. ,84 A 0

ATOM 1301 N HIS A 103 -2. 052 -2. 074 -65. ,144 1.00 47. ,39 A N

ATOM 1302 CA HIS A 103 -2. 747 -1. 077 -65. ,983 1.00 45. ,26 A c

ATOM 1304 CB HIS A 103 -1. 899 0. 213 -66. ,095 1.00 41.65 A c

ATOM 1307 CG HIS A 103 -1. 121 0. 522 -64. ,850 1.00 37, .76 A c

ATOM 1308 NDl HIS A 103 -1. 729 0. 844 -63. ,655 1.00 34, .62 A N

ATOM 1310 CEl HIS A 103 -0. 805 1. 037 -62. ,731 1.00 34. ,36 A c

ATOM 1312 NE2 HIS A 103 0. 381 0. 843 -63. ,280 1.00 36. .63 A N

ATOM 1314 CD2 HIS A 103 0. 211 0. 509 -64. ,602 1.00 36. ,74 A c

ATOM 1316 C HIS A 103 -3. 132 -1. 640 -67. ,354 1.00 45. .07 A c

ATOM 1317 0 HIS A 103 -3. 148 -0. 919 -68. ,353 1.00 43. ,47 A 0

ATOM 1319 N ASP A 104 -3. 490 -2. 926 -67. ,372 1.00 44. ,83 A N

ATOM 1320 CA ASP A 104 -3. 675 -3. 683 -68. ,606 1.00 40. 82 A c

ATOM 1322 CB ASP A 104 -3. 423 -5. 186 -68. ,331 1.00 41.92 A c

ATOM 1325 CG ASP A 104 -3. 325 -6. 047 -69. ,618 1.00 44, .77 A c

ATOM 1326 ODl ASP A 104 -3. 169 -5. 507 -70. ,729 1.00 45, .72 A 0

ATOM 1327 OD2 ASP A 104 -3. 382 -7. 292 -69. ,513 1.00 49, ,37 A 0

ATOM 1328 C ASP A 104 -5. 076 -3. 442 -69. .170 1.00 37, .29 A c

ATOM 1329 0 ASP A 104 -5. 790 -4. 387 -69. ,490 1.00 30, .84 A 0

ATOM 1331 N LEU A 105 -5. 466 -2. 170 -69. ,280 1.00 35. .98 A N

ATOM 1332 CA LEU A 105 -6. 743 -1. 799 -69. ,867 1.00 34, .54 A c

ATOM 1334 CB LEU A 105 -7. 544 -0. 910 -68. ,921 1.00 35. ,42 A c

ATOM 1337 CG LEU A 105 -7. 979 -1. 506 -67. ,581 1.00 33, .22 A c

ATOM 1339 CDl LEU A 105 -8. 839 -0. 492 -66. ,850 1.00 28, .96 A c

ATOM 1343 CD2 LEU A 105 -8. 737 -2. 837 -67. ,747 1.00 31.61 A c

ATOM 1347 C LEU A 105 -6. 527 -1. 103 -71. ,207 1.00 35, ,95 A c

ATOM 1348 0 LEU A 105 -5. 550 -0. 386 -71. ,408 1.00 40, .58 A 0

ATOM 1350 N LEU A 106 -7. 447 -1. 357 -72. ,127 1.00 36, .94 A N

ATOM 1351 CA LEU A 106 -7. 431 -0. 781 -73. ,459 1.00 35, .20 A c cyno fD_Fab

ATOM 1353 CB LEU A 106 -7. .010 -1. 838 -74. 479 1. 00 34. 88 A C

ATOM 1356 CG LEU A 106 -7. ,125 -1. 549 -75. 979 1. 00 36. 10 A c

ATOM 1358 CDl LEU A 106 -6. ,028 -0. 611 -76. 466 1. 00 33. 22 A c

ATOM 1362 CD2 LEU A 106 -7. ,082 -2. 856 -76. 752 1. 00 32. ,99 A c

ATOM 1366 C LEU A 106 -8. ,846 -0. 317 -73. 738 1. 00 37. 09 A c

ATOM 1367 O LEU A 106 -9. ,812 -0. 980 -73. 371 1. 00 37. ,21 A 0

ATOM 1369 N LEU A 107 -8. ,973 0. 836 -74. 375 1. 00 39. 36 A N

ATOM 1370 CA LEU A 107 -10. ,270 1. 343 -74. 752 1. 00 35. 19 A c

ATOM 1372 CB LEU A 107 -10. ,580 2. 625 -73. 979 1. 00 31. 79 A c

ATOM 1375 CG LEU A 107 -11.338 2. 439 -72. 659 1. 00 30. 33 A c

ATOM 1377 CDl LEU A 107 -11. ,613 3. 785 -71. 968 1. 00 23. 53 A c

ATOM 1381 CD2 LEU A 107 -12. ,663 1. 684 -72. 895 1. 00 24. 74 A c

ATOM 1385 C LEU A 107 -10. ,259 1. 576 -76. 251 1. 00 38. 00 A c

ATOM 1386 O LEU A 107 -9. ,451 2. 351 -76.742 1. 00 39. 53 A 0

ATOM 1388 N LEU A 108 -11. ,147 0. 885 -76. 966 1. 00 38. 84 A N

ATOM 1389 CA LEU A 108 -11. ,254 0. 973 -78. 418 1. 00 37. 78 A c

ATOM 1391 CB LEU A 108 -11.380 -0. 425 -79. 031 1. 00 39. ,49 A c

ATOM 1394 CG LEU A 108 -10. ,414 -1. 507 -78. 546 1. 00 41. ,19 A c

ATOM 1396 CDl LEU A 108 -10. ,821 -2. 845 -79. 112 1. 00 40. 38 A c

ATOM 1400 CD2 LEU A 108 -8. ,984 -1. 162 -78. 923 1. 00 43. 02 A c

ATOM 1404 C LEU A 108 -12. ,493 1. 779 -78. 787 1. 00 38. 88 A c

ATOM 1405 O LEU A 108 -13. ,588 1. 505 -78. 280 1. 00 33. 01 A 0

ATOM 1407 N GLN A 109 -12. ,315 2. 759 -79. 673 1. 00 40. 03 A N

ATOM 1408 CA GLN A 109 -13. ,413 3. 569 -80. 190 1. 00 40. 00 A c

ATOM 1410 CB GLN A 109 -12. ,951 5. 016 -80. 402 1. 00 40. ,30 A c

ATOM 1413 CG GLN A 109 -14. 083 5. 988 -80. 679 1. 00 40. 09 A c

ATOM 1416 CD GLN A 109 -13. 609 7. 411 -80. 911 1. 00 42. ,61 A c

ATOM 1417 OEl GLN A 109 -12. 414 7. 672 -81.064 1. 00 47. 69 A 0

ATOM 1418 NE2 GLN A 109 -14. 550 8. 340 -80. 937 1. 00 43. 20 A N

ATOM 1421 C GLN A 109 -13. 914 2. 985 -81. 517 1. 00 40. 89 A c

ATOM 1422 O GLN A 109 -13. ,130 2. 800 -82. 454 1. 00 39. 69 A 0

ATOM 1424 N LEU A 110 -15. ,216 2. 708 -81. 595 1. 00 41. 85 A N

ATOM 1425 CA LEU A 110 -15. 821 2. 093 -82. 783 1. 00 41. 85 A c

ATOM 1427 CB LEU A 110 -17. ,154 1. 436 -82.416 1. 00 38. ,43 A c

ATOM 1430 CG LEU A 110 -17. ,154 0. 429 -81. 264 1. 00 35. 60 A c

ATOM 1432 CDl LEU A 110 -18. ,564 -0. 114 -81. 042 1. 00 36. 56 A c

ATOM 1436 CD2 LEU A 110 -16. ,180 -0. 692 -81. 537 1. 00 31. ,67 A c

ATOM 1440 C LEU A 110 -16. 055 3. 126 -83. 892 1. 00 45. ,42 A c

ATOM 1441 O LEU A 110 -16. ,340 4. 297 -83. 609 1. 00 47. ,04 A 0

ATOM 1443 N SER A 111 -15. 960 2. 679 -85. 147 1. 00 46. 26 A N

ATOM 1444 CA SER A 111 -16. ,089 3. 566 -86. 318 1. 00 45. ,73 A c

ATOM 1446 CB SER A 111 -16. ,034 2. 772 -87. 632 1. 00 46. ,17 A c

ATOM 1449 OG SER A 111 -17. ,005 1. 734 -87. 676 1. 00 48. ,13 A 0

ATOM 1451 C SER A 111 -17. ,354 4. 408 -86. 256 1. 00 45. ,74 A c

ATOM 1452 O SER A 111 -17. ,344 5. 571 -86. 645 1. 00 47. ,20 A 0

ATOM 1454 N GLU A 112 -18. ,435 3. 814 -85. ,763 1. 00 47. ,37 A N

ATOM 1455 CA GLU A 112 -19. ,647 4. 556 -85. ,413 1. 00 47. ,46 A c

ATOM 1457 CB GLU A 112 -20. ,674 4. 438 -86. 537 1. 00 51. ,04 A c

ATOM 1460 CG GLU A 112 -21. 236 3. 034 -86. ,716 1. 00 53. ,20 A c

ATOM 1463 CD GLU A 112 -21. ,724 2. 780 -88. ,125 1. 00 54. ,56 A c

ATOM 1464 OEl GLU A 112 -22. ,952 2. 624 -88. ,313 1. 00 56. ,44 A 0

ATOM 1465 OE2 GLU A 112 -20. ,872 2. 749 -89. ,042 1. 00 56. ,51 A 0

ATOM 1466 C GLU A 112 -20. ,220 4. 006 -84. ,102 1. 00 43. ,04 A c

ATOM 1467 O GLU A 112 -19. ,798 2. 951 -83. ,637 1. ,00 40. ,01 A 0

ATOM 1469 N LYS A 113 -21. ,163 4. 723 -83. ,499 1. 00 41. ,20 A N

ATOM 1470 CA LYS A 113 -21. ,879 4. 197 -82. ,337 1. ,00 42. ,99 A c

ATOM 1472 CB LYS A 113 -22. ,931 5. 182 -81. ,843 1. ,00 45. ,82 A c

ATOM 1475 CG LYS A 113 -22. ,379 6. 343 -81. ,055 1. 00 48, ,42 A c

ATOM 1478 CD LYS A 113 -23. ,482 7. 358 -80. ,815 1. 00 48. .08 A c

ATOM 1481 CE LYS A 113 -23. ,098 8. 384 -79. ,768 1. ,00 49. ,62 A c

ATOM 1484 NZ LYS A 113 -24. ,150 9. 445 -79. 662 1. 00 51. .88 A N

ATOM 1488 C LYS A 113 -22. ,567 2. 883 -82. ,700 1. 00 41. .20 A c

ATOM 1489 O LYS A 113 -23. ,182 2. 774 -83. ,764 1. 00 39. ,17 A 0

ATOM 1491 N ALA A 114 -22. ,469 1. 893 -81. ,815 1. ,00 38. .73 A N

ATOM 1492 CA ALA A 114 -23. ,059 0. 580 -82. ,065 1. ,00 37. ,42 A c

ATOM 1494 CB ALA A 114 -22. ,527 -0. 452 -81. ,074 1. ,00 33. ,40 A c

ATOM 1498 C ALA A 114 -24. ,586 0. 653 -82. Oil 1. ,00 36. ,87 A c

ATOM 1499 O ALA A 114 -25. 172 1. 375 -81. ,190 1. ,00 35. ,52 A 0 cyno fD_Fab

ATOM 1501 N THR A 115 -25. ,218 -0. 080 -82. ,923 1.00 36. 64 A N

ATOM 1502 CA THR A 115 -26. ,667 -0. 188 -82. ,974 1.00 36. 58 A C

ATOM 1504 CB THR A 115 -27. ,126 -0. 775 -84. ,333 1.00 40. 02 A C

ATOM 1506 OGl THR A 115 -26. ,687 0. 079 -85. ,399 1.00 42. 05 A 0

ATOM 1508 CG2 THR A 115 -28. 629 -0. 922 -84. 386 1.00 36. 82 A c

ATOM 1512 C THR A 115 -27. 138 -1. 091 -81. 835 1.00 34. 85 A c

ATOM 1513 O THR A 115 -26. 779 -2. 279 -81.781 1.00 32. 31 A 0

ATOM 1515 N LEU A 116 -27. 936 -0. 523 -80. ,933 1.00 32. 03 A N

ATOM 1516 CA LEU A 116 -28. 389 -1. 227 -79. ,736 1.00 32. 60 A C

ATOM 1518 CB LEU A 116 -28. 602 -0. 243 -78. ,577 1.00 32. 00 A C

ATOM 1521 CG LEU A 116 -27. 403 0. 615 -78. ,143 1.00 28. 88 A c

ATOM 1523 CDl LEU A 116 -27. 726 1. 352 -76. ,843 1.00 24. 99 A c

ATOM 1527 CD2 LEU A 116 -26. 123 -0. 220 -78. ,012 1.00 25. 50 A c

ATOM 1531 C LEU A 116 -29. 671 -2. 018 -79. 980 1.00 34. 30 A c

ATOM 1532 O LEU A 116 -30. 461 -1. 691 -80. 858 1.00 38. 89 A 0

ATOM 1534 N GLY A 117 -29. 868 -3. 058 -79. 176 1.00 33. 76 A N

ATOM 1535 CA GLY A 117 -31. 016 -3. 956 -79. 297 1.00 32. 80 A c

ATOM 1538 C GLY A 117 -30. 907 -5. 064 -78. 267 1.00 32. 90 A c

ATOM 1539 O GLY A 117 -30.037 -5. 008 -77. 390 1.00 33. 29 A 0

ATOM 1541 N PRO A 118 -31. 773 -6. 086 -78. 364 1.00 28. 40 A N

ATOM 1542 CA PRO A 118 -31.716 -7. 213 -77. 422 1.00 28. 96 A c

ATOM 1544 CB PRO A 118 -32. 839 -8. 136 -77. 909 1.00 27. 74 A c

ATOM 1547 CG PRO A 118 -33. 731 -7. 266 -78. 725 1.00 27. 98 A c

ATOM 1550 CD PRO A 118 -32. 849 -6. 248 -79. 350 1.00 28. 83 A c

ATOM 1553 C PRO A 118 -30. ,357 -7. 940 -77. 423 1.00 26. 11 A c

ATOM 1554 O PRO A 118 -29. ,938 -8. 506 -76. ,403 1.00 16. 45 A 0

ATOM 1555 N ALA A 119 -29. ,666 -7. 898 -78. 559 1.00 27. 71 A N

ATOM 1556 CA ALA A 119 -28. 384 -8. 572 -78. ,703 1.00 26. 41 A c

ATOM 1558 CB ALA A 119 -28. 332 -9. 287 -80. ,059 1.00 26. 95 A c

ATOM 1562 C ALA A 119 -27. 151 -7. 662 -78. ,525 1.00 24. 69 A c

ATOM 1563 O ALA A 119 -26. 037 -8. 160 -78. ,492 1.00 19. 22 A 0

ATOM 1565 N VAL A 120 -27. 341 -6. 345 -78. 428 1.00 26. 99 A N

ATOM 1566 CA VAL A 120 -26. 226 -5. 408 -78. 244 1.00 27. 02 A c

ATOM 1568 CB VAL A 120 -25. ,763 -4. 803 -79. ,586 1.00 27. 33 A c

ATOM 1570 CGl VAL A 120 -24. ,419 -4. 063 -79. ,402 1.00 23. 51 A c

ATOM 1574 CG2 VAL A 120 -25. ,665 -5. 890 -80. ,668 1.00 20. 31 A c

ATOM 1578 C VAL A 120 -26. 596 -4. 276 -77. ,270 1.00 29. 45 A c

ATOM 1579 O VAL A 120 -27. 522 -3. 515 -77. ,521 1.00 26. 76 A 0

ATOM 1581 N ARG A 121 -25. 863 -4. 172 -76. ,162 1.00 31. 36 A N

ATOM 1582 CA ARG A 121 -26. 207 -3. 254 -75. ,076 1.00 31. 87 A c

ATOM 1584 CB ARG A 121 -27. 372 -3. 842 -74. ,283 1.00 34. 09 A c

ATOM 1587 CG ARG A 121 -28. 227 -2. 832 -73. ,527 1.00 37. 38 A c

ATOM 1590 CD ARG A 121 -29. 287 -3. 547 -72. ,696 1.00 40. 86 A c

ATOM 1593 NE ARG A 121 -29. 883 -4. 663 -73. ,437 1.00 41. 78 A N

ATOM 1595 CZ ARG A 121 -30. 148 -5. 871 -72. ,936 1.00 45. 05 A c

ATOM 1596 NHl ARG A 121 -30. 680 -6. 806 -73. ,719 1.00 47. 24 A N

ATOM 1599 NH2 ARG A 121 -29. 884 -6. 166 -71. ,667 1.00 47. 24 A N

ATOM 1602 C ARG A 121 -25. 001 -3. 034 -74. ,137 1.00 31. 61 A c

ATOM 1603 O ARG A 121 -24. 366 -4. 005 -73. ,723 1.00 31. 41 A 0

ATOM 1605 N PRO A 122 -24. 673 -1. 763 -73. ,809 1.00 30. 34 A N

ATOM 1606 CA PRO A 122 -23. 581 -1. 489 -72. ,860 1.00 30. 39 A C

ATOM 1608 CB PRO A 122 -23. ,503 0. 042 -72. ,836 1.00 32. 00 A c

ATOM 1611 CG PRO A 122 -24. 216 0. 492 -74, ,067 1.00 31. ,57 A c

ATOM 1614 CD PRO A 122 -25. ,268 -0. 517 -74, ,322 1.00 30. 60 A c

ATOM 1617 C PRO A 122 -23. ,814 -2. 024 -71. ,447 1.00 25. 43 A c

ATOM 1618 O PRO A 122 -24. ,944 -2. 163 -71, ,015 1.00 23. 87 A 0

ATOM 1619 N LEU A 123 -22. 728 -2. 359 -70. ,755 1.00 30. 90 A N

ATOM 1620 CA LEU A 123 -22. ,817 -2. 854 -69. ,389 1.00 32. 21 A C

ATOM 1622 CB LEU A 123 -21.986 -4. 139 -69. 198 1.00 30. 54 A C

ATOM 1625 CG LEU A 123 -22. 033 -4. 820 -67. 818 1.00 27. 61 A c

ATOM 1627 CDl LEU A 123 -21. ,136 -6. 046 -67, ,760 1.00 17. ,80 A c

ATOM 1631 CD2 LEU A 123 -23. ,494 -5. 164 -67, ,440 1.00 25. ,49 A c

ATOM 1635 C LEU A 123 -22. ,303 -1. 767 -68, ,464 1.00 30. ,39 A c

ATOM 1636 O LEU A 123 -21. ,207 -1. 249 -68. ,681 1.00 26. ,88 A 0

ATOM 1638 N PRO A 124 -23. ,092 -1. 418 -67. ,433 1.00 35. 06 A N

ATOM 1639 CA PRO A 124 -22. ,555 -0. 531 -66, ,402 1.00 34. 73 A c

ATOM 1641 CB PRO A 124 -23. ,741 -0. 345 -65. ,430 1.00 39. 14 A c

ATOM 1644 CG PRO A 124 -24. ,700 -1. 453 -65. ,733 1.00 40. 11 A c cyno fD_Fab

ATOM 1647 CD PRO A 124 -24. ,505 -1. 771 -67. 181 1.00 38. ,23 A C

ATOM 1650 C PRO A 124 -21. ,313 -1. 089 -65. 676 1.00 32. ,26 A C

ATOM 1651 O PRO A 124 -21.273 -2. 264 -65. 283 1.00 28. ,04 A 0

ATOM 1652 N TRP A 125 -20. 310 -0. 236 -65. 504 1.00 31. ,91 A N

ATOM 1653 CA TRP A 125 -19. ,084 -0. 625 -64. 807 1.00 32. ,31 A C

ATOM 1655 CB TRP A 125 -17. 848 -0. 362 -65. 657 1.00 33. ,29 A C

ATOM 1658 CG TRP A 125 -17. 770 0. 982 -66. 241 1.00 34. ,47 A C

ATOM 1659 CDl TRP A 125 -18. 289 1. 383 -67. 430 1.00 34. ,55 A C

ATOM 1661 NEl TRP A 125 -17. 999 2. 709 -67. 648 1.00 35. ,86 A N

ATOM 1663 CE2 TRP A 125 -17. ,258 3. 180 -66. 596 1.00 36. 20 A C

ATOM 1664 CD2 TRP A 125 -17. 098 2. 116 -65. 687 1.00 34. ,68 A c

ATOM 1665 CE3 TRP A 125 -16. 377 2. 336 -64. 511 1.00 34. ,48 A c

ATOM 1667 CZ3 TRP A 125 -15. 853 3. 600 -64. 276 1.00 34. ,53 A c

ATOM 1669 CH2 TRP A 125 -16. 032 4. 635 -65. 197 1.00 34. ,74 A c

ATOM 1671 CZ2 TRP A 125 -16. 733 4. 448 -66. 360 1.00 34. ,53 A c

ATOM 1673 C TRP A 125 -18. 969 0. 041 -63. 451 1.00 29. ,37 A c

ATOM 1674 O TRP A 125 -19. 577 1. 088 -63. 196 1.00 34. ,09 A 0

ATOM 1676 N GLN A 126 -18. 218 -0. 600 -62. 569 1.00 26. ,16 A N

ATOM 1677 CA GLN A 126 -18. 121 -0. 157 -61. 189 1.00 29. ,58 A c

ATOM 1679 CB GLN A 126 -17. 451 -1. 221 -60. 320 1.00 25. ,64 A c

ATOM 1682 CG GLN A 126 -17. 459 -0. 888 -58. 842 1.00 19. ,78 A c

ATOM 1685 CD GLN A 126 -18. 852 -0. 619 -58. 329 1.00 18. ,10 A c

ATOM 1686 OEl GLN A 126 -19. 296 0. 527 -58. 279 1.00 17. ,29 A 0

ATOM 1687 NE2 GLN A 126 -19. 552 -1. 668 -57. 949 1.00 14. ,16 A N

ATOM 1690 C GLN A 126 -17. 343 1. 145 -61.083 1.00 30. ,89 A c

ATOM 1691 O GLN A 126 -16. ,197 1. 231 -61. 512 1.00 33. ,51 A 0

ATOM 1693 N ARG A 127 -17. 988 2. 153 -60. 512 1.00 33. ,83 A N

ATOM 1694 CA ARG A 127 -17. 376 3. 451 -60. 291 1.00 34. ,13 A c

ATOM 1696 CB ARG A 127 -18. 417 4. 533 -60. 572 1.00 37. ,02 A c

ATOM 1699 CG ARG A 127 -17. 869 5. 946 -60. 715 1.00 41. ,30 A c

ATOM 1702 CD ARG A 127 -18. 941 6. 915 -61. 265 1.00 39. ,98 A c

ATOM 1705 NE ARG A 127 -19. 246 6. 617 -62. 664 1.00 38. ,47 A N

ATOM 1707 cz ARG A 127 -18. 464 6. 934 -63. 695 1.00 41. ,59 A c

ATOM 1708 NHl ARG A 127 -17. 313 7. 573 -63. 509 1.00 39. ,96 A N

ATOM 1711 NH2 ARG A 127 -18. 831 6. 601 -64. 932 1.00 43. ,49 A N

ATOM 1714 C ARG A 127 -16. 826 3. 545 -58. 857 1.00 32. ,75 A C

ATOM 1715 0 ARG A 127 -15. 886 4. 297 -58. 604 1.00 32. ,40 A 0

ATOM 1717 N VAL A 128 -17. 405 2. 765 -57. 938 1.00 31. ,02 A N

ATOM 1718 CA VAL A 128 -17. 062 2. 804 -56. 513 1.00 27. ,97 A C

ATOM 1720 CB VAL A 128 -18. 278 2. 450 -55. 623 1.00 23. ,37 A C

ATOM 1722 CGI VAL A 128 -17. 986 2. 685 -54. 154 1.00 18. ,75 A C

ATOM 1726 CG2 VAL A 128 -19. 488 3. 279 -56. 024 1.00 21. ,92 A C

ATOM 1730 C VAL A 128 -15. 900 1. 844 -56. 231 1.00 30. ,41 A C

ATOM 1731 0 VAL A 128 -16. 021 0. 619 -56. 361 1.00 29. ,19 A 0

ATOM 1733 N ASP A 129 -14. 760 2. 416 -55. 864 1.00 30. ,07 A N

ATOM 1734 CA ASP A 129 -13. 549 1. 649 -55. 654 1.00 28. ,11 A c

ATOM 1736 CB ASP A 129 -12. ,346 2. 587 -55. 692 1.00 29. ,47 A c

ATOM 1739 CG ASP A 129 -11. 026 1. 863 -55. 692 1.00 30.18 A c

ATOM 1740 001 ASP A 129 -10. 958 0. 669 -55. 333 1.00 33. ,10 A 0

ATOM 1741 002 ASP A 129 -10. 033 2. 515 -56. 053 1.00 33. ,04 A 0

ATOM 1742 C ASP A 129 -13. 678 0. 938 -54. 316 1.00 28. ,31 A c

ATOM 1743 0 ASP A 129 -13. 262 1. 442 -53. 287 1.00 29. ,24 A 0

ATOM 1745 N ARG A 130 -14. ,321 -0. 220 -54. 346 1.00 30. ,53 A N

ATOM 1746 CA ARG A 130 -14. ,424 -1. 094 -53. 192 1.00 30. ,04 A c

ATOM 1748 CB ARG A 130 -15. 767 -0. 893 -52. 511 1.00 33. ,92 A c

ATOM 1751 CG ARG A 130 -16. 039 -1. 790 -51. 322 1.00 35. ,80 A c

ATOM 1754 CD ARG A 130 -17. 468 -1. 565 -50. 788 1.00 39. ,17 A c

ATOM 1757 NE ARG A 130 -17. 680 -2. 219 -49. 493 1.00 41. ,40 A N

ATOM 1759 CZ ARG A 130 -17. 443 -1. 661 -48. 300 1.00 46. 86 A c

ATOM 1760 NHl ARG A 130 -16. 971 -0. 415 -48. 200 1.00 48. ,12 A N

ATOM 1763 NH2 ARG A 130 -17. 682 -2. 358 -47. 185 1.00 46.18 A N

ATOM 1766 C ARG A 130 -14. 256 -2. 529 -53. 699 1.00 28. ,00 A c

ATOM 1767 0 ARG A 130 -14. ,777 -2. 875 -54. 760 1.00 26. ,51 A 0

ATOM 1769 N ASP A 131 -13. ,511 -3. 344 -52. 949 1.00 27. ,78 A N

ATOM 1770 CA ASP A 131 -13. 187 -4. 714 -53. 363 1.00 25. ,39 A C

ATOM 1772 CB ASP A 131 -12. 216 -5. 387 -52. 371 1.00 24. ,95 A C

ATOM 1775 CG ASP A 131 -10. ,754 -5. 051 -52. 619 1.00 23. ,96 A C

ATOM 1776 ODl ASP A 131 -10. 361 -4. 619 -53. 723 1.00 25. ,08 A 0 cyno fD_Fab

ATOM 1777 OD2 ASP A 131 -9.977 -5. 255 -51. 677 1.00 23.47 A 0

ATOM 1778 C ASP A 131 -14. 443 -5. 559 -53. 402 1.00 23.52 A c

ATOM 1779 O ASP A 131 -15. 295 -5. 432 -52. 532 1.00 19.47 A 0

ATOM 1781 N VAL A 132 -14. 535 -6. ,442 -54. 392 1.00 22.52 A N

ATOM 1782 CA VAL A 132 -15. 532 -7. 497 -54. 362 1.00 21.16 A c

ATOM 1784 CB VAL A 132 -15. 576 -8. 302 -55. 681 1.00 20.45 A c

ATOM 1786 CGI VAL A 132 -16. 623 -9. 379 -55. 617 1.00 14.62 A c

ATOM 1790 CG2 VAL A 132 -15. 837 -7. 389 -56. 870 1.00 22.18 A c

ATOM 1794 C VAL A 132 -15. 158 -8. 430 -53. 217 1.00 18.80 A c

ATOM 1795 O VAL A 132 -13. 992 -8. 835 -53. 075 1.00 18.64 A 0

ATOM 1797 N GLU A 133 -16. 141 -8. 772 -52. 394 1.00 15.31 A N

ATOM 1798 CA GLU A 133 -15. 892 -9. 622 -51. 246 1.00 21.58 A c

ATOM 1800 CB GLU A 133 -17. 151 -9. ,796 -50. 396 1.00 22.06 A c

ATOM 1803 CG GLU A 133 -17. 641 -8. 524 -49. 766 1.00 26.27 A c

ATOM 1806 CD GLU A 133 -19. 041 -8. 663 -49. 163 1.00 27.46 A c

ATOM 1807 OEl GLU A 133 -19. 952 -7. 925 -49. 601 1.00 37.11 A 0

ATOM 1808 OE2 GLU A 133 -19. 228 -9. 514 -48. 269 1.00 29.31 A 0

ATOM 1809 C GLU A 133 -15. 420 -10. 990 -51.710 1.00 25.15 A c

ATOM 1810 O GLU A 133 -15. 907 -11. 501 -52. 720 1.00 24.26 A 0

ATOM 1812 N PRO A 134 -14. 468 -11. 585 -50. 974 1.00 24.40 A N

ATOM 1813 CA PRO A 134 -14. 053 -12. ,941 -51. 259 1.00 20.18 A c

ATOM 1815 CB PRO A 134 -13. 000 -13. 212 -50. 181 1.00 24.61 A c

ATOM 1818 CG PRO A 134 -12. 485 -11. 887 -49. 830 1.00 25.72 A c

ATOM 1821 CD PRO A 134 -13. 704 -11. 024 -49. 846 1.00 24.65 A c

ATOM 1824 C PRO A 134 -15. 178 -13. 972 -51. 196 1.00 19.06 A c

ATOM 1825 O PRO A 134 -16. 071 -13. 903 -50. 320 1.00 23.00 A 0

ATOM 1826 N GLY A 135 -15. 138 -14. 901 -52. 151 1.00 16.00 A N

ATOM 1827 CA GLY A 135 -16. 135 -15. 969 -52. 286 1.00 19.31 A c

ATOM 1830 C GLY A 135 -17. 420 -15. 591 -53. 022 1.00 18.48 A c

ATOM 1831 O GLY A 135 -18. 322 -16. ,424 -53. 165 1.00 20.40 A 0

ATOM 1833 N THR A 136 -17. 510 -14. ,341 -53. 478 1.00 18.76 A N

ATOM 1834 CA THR A 136 -18. 633 -13. 880 -54. 286 1.00 20.67 A c

ATOM 1836 CB THR A 136 -18. 615 -12. 349 -54. 505 1.00 19.72 A c

ATOM 1838 OGl THR A 136 -18. 633 -11. 661 -53. 243 1.00 17.99 A 0

ATOM 1840 CG2 THR A 136 -19. 819 -11. 940 -55. 320 1.00 20.71 A c

ATOM 1844 C THR A 136 -18. 518 -14. 539 -55. 645 1.00 20.59 A c

ATOM 1845 O THR A 136 -17. 415 -14. 670 -56. 169 1.00 18.04 A 0

ATOM 1847 N LEU A 137 -19. 641 -14. ,979 -56. 201 1.00 19.97 A N

ATOM 1848 CA LEU A 137 -19. 612 -15. ,657 -57. ,488 1.00 19.18 A c

ATOM 1850 CB LEU A 137 -20. 753 -16. 659 -57. 609 1.00 20.25 A c

ATOM 1853 CG LEU A 137 -20. 765 -17. ,816 -56. 610 1.00 21.94 A c

ATOM 1855 CDl LEU A 137 -22. 002 -18. 690 -56. 843 1.00 21.46 A c

ATOM 1859 CD2 LEU A 137 -19. 506 -18. ,616 -56. 734 1.00 13.55 A c

ATOM 1863 C LEU A 137 -19. 723 -14. 632 -58. 583 1.00 15.01 A c

ATOM 1864 O LEU A 137 -20. 642 -13. ,829 -58. 593 1.00 11.15 A 0

ATOM 1866 N CYS A 138 -18. 783 -14. ,658 -59. 518 1.00 13.68 A N

ATOM 1867 CA CYS A 138 -18. 829 -13. ,748 -60. 661 1.00 15.36 A C

ATOM 1869 CB CYS A 138 -17. 684 -12. ,727 -60. ,614 1.00 16.13 A C

ATOM 1872 SG CYS A 138 -17. 641 -11. ,707 -59. ,094 1.00 21.12 A s

ATOM 1874 C CYS A 138 -18. 764 -14. ,544 -61. 943 1.00 17.49 A c

ATOM 1875 O CYS A 138 -18. 321 -15. ,667 -61. ,952 1.00 19.85 A 0

ATOM 1877 N ASP A 139 -19. 173 -13. ,916 -63. 032 1.00 19.19 A N

ATOM 1878 CA ASP A 139 -19. 345 -14. ,581 -64. 299 1.00 15.10 A c

ATOM 1880 CB ASP A 139 -20. 740 -14. ,264 -64. ,819 1.00 17.61 A c

ATOM 1883 CG ASP A 139 -21. 160 -15. ,174 -65. 928 1.00 21.30 A c

ATOM 1884 ODl ASP A 139 -21. 399 -16. ,352 -65. ,648 1.00 25.60 A 0

ATOM 1885 OD2 ASP A 139 -21. 239 -14. ,716 -67. ,077 1.00 23.89 A 0

ATOM 1886 C ASP A 139 -18. 283 -14. ,057 -65. ,259 1.00 15.36 A c

ATOM 1887 O ASP A 139 -18. 126 -12. ,848 -65. ,417 1.00 18.19 A 0

ATOM 1889 N VAL A 140 -17. 546 -14. ,968 -65. ,877 1.00 18.90 A N

ATOM 1890 CA VAL A 140 -16. 601 -14. ,608 -66. ,941 1.00 18.35 A c

ATOM 1892 CB VAL A 140 -15. 122 -14. ,901 -66. ,539 1.00 22.08 A c

ATOM 1894 CGI VAL A 140 -14. 921 -16. ,356 -66. ,193 1.00 21.93 A c

ATOM 1898 CG2 VAL A 140 -14. 117 -14. ,463 -67. ,648 1.00 23.84 A c

ATOM 1902 C VAL A 140 -17. 061 -15. ,333 -68. ,202 1.00 18.31 A c

ATOM 1903 0 VAL A 140 -17. 445 -16. ,504 -68. ,150 1.00 17.82 A 0

ATOM 1905 N ALA A 141 -17. 096 -14, ,608 -69. ,317 1.00 21.26 A N

ATOM 1906 CA ALA A 141 -17. 490 -15. ,162 -70. ,615 1.00 19.01 A c fD_Fab

ATOM 1908 CB ALA A 141 -18. -14. ,500 -71. ,118 1.00 17. ,39 A C

ATOM 1912 C ALA A 141 -16. 360 -14. ,967 -71.610 1.00 20. ,81 A C

ATOM 1913 O ALA A 141 -15. 548 -14. ,072 -71. 457 1.00 22. ,40 A 0

ATOM 1915 N GLY A 142 -16. 288 -15. 827 -72. ,621 1.00 22. 29 A N

ATOM 1916 CA GLY A 142 -15. 306 -15. 632 -73. 681 1.00 19. 78 A c

ATOM 1919 C GLY A 142 -15. 312 -16. 707 -74. 745 1.00 20. 65 A c

ATOM 1920 O GLY A 142 -15. 984 -17. 732 -74. 614 1.00 21. 03 A 0

ATOM 1922 N T P A 143 -14. 507 -16. ,465 -75. ,779 1.00 28. 34 A N

ATOM 1923 CA TRP A 143 -14. 278 -17. 393 -76. ,881 1.00 22. ,99 A c

ATOM 1925 CB TRP A 143 -14. 507 -16. 686 -78. ,222 1.00 25. 86 A c

ATOM 1928 CG TRP A 143 -15. 937 -16. 410 -78. 552 1.00 25. ,28 A c

ATOM 1929 CDl TRP A 143 -16. 807 -17. ,278 -79. 103 1.00 23. 95 A c

ATOM 1931 NEl TRP A 143 -18. 029 -16. 680 -79. ,278 1.00 24. 46 A N

ATOM 1933 CE2 TRP A 143 -17. 967 -15. 390 -78. ,829 1.00 23. 90 A c

ATOM 1934 CD2 TRP A 143 -16. 653 -15. 177 -78. ,368 1.00 24. 99 A c

ATOM 1935 CE3 TRP A 143 -16. 316 -13. 923 -77. ,848 1.00 21. 01 A c

ATOM 1937 CZ3 TRP A 143 -17. 278 -12. 944 -77. 809 1.00 24. 74 A c

ATOM 1939 CH2 TRP A 143 -18. 583 -13. 176 -78. 283 1.00 23. 16 A c

ATOM 1941 CZ2 TRP A 143 -18. 948 -14. 394 -78. ,793 1.00 24. 14 A c

ATOM 1943 C TRP A 143 -12. 846 -17. 909 -76. 822 1.00 29. 13 A c

ATOM 1944 O TRP A 143 -12. 305 -18. ,415 -77. ,820 1.00 27. 75 A 0

ATOM 1946 N GLY A 144 -12. 250 -17. 793 -75. ,638 1.00 27. ,30 A N

ATOM 1947 CA GLY A 144 -10. 943 -18. 339 -75. ,375 1.00 28. 04 A c

ATOM 1950 C GLY A 144 -10. 963 -19. 850 -75. ,320 1.00 27. 63 A c

ATOM 1951 O GLY A 144 -12. 025 -20. 464 -75. ,246 1.00 28. 04 A 0

ATOM 1953 N ILE A 145 -9. 771 -20. 432 -75. ,355 1.00 26. 81 A N

ATOM 1954 CA ILE A 145 -9. 597 -21. 888 -75. ,442 1.00 29. 71 A c

ATOM 1956 CB ILE A 145 -8. 080 -22. 271 -75. ,431 1.00 32. 32 A c

ATOM 1958 CGl ILE A 145 -7. 419 -21.937 -74. ,083 1.00 31. 00 A c

ATOM 1961 CDl ILE A 145 -5. 958 -22. 280 -74. ,019 1.00 33. 83 A c

ATOM 1965 CG2 ILE A 145 -7. 362 -21. 508 -76. ,537 1.00 30. 15 A c

ATOM 1969 C ILE A 145 -10. 359 -22. 631 -74. ,350 1.00 27. 12 A c

ATOM 1970 O ILE A 145 -10. 476 -22. 145 -73. 237 1.00 30. 94 A 0

ATOM 1972 N VAL A 146 -10. 891 -23. ,796 -74. ,708 1.00 25. 62 A N

ATOM 1973 CA VAL A 146 -11. 730 -24. ,609 -73. ,837 1.00 26. 26 A C

ATOM 1975 CB VAL A 146 -13. 074 -24. ,958 -74. 539 1.00 24. 91 A C

ATOM 1977 CGl VAL A 146 -14. 002 -23. 723 -74. ,566 1.00 15. 51 A c

ATOM 1981 CG2 VAL A 146 -12. 849 -25. 479 -75. ,964 1.00 20. ,43 A c

ATOM 1985 C VAL A 146 -11. 026 -25. 888 -73. ,347 1.00 27. 98 A c

ATOM 1986 O VAL A 146 -11. 577 -26. 639 -72. ,546 1.00 28. 80 A 0

ATOM 1988 N SER A 147 -9. 799 -26. 089 -73. ,830 1.00 29. 57 A N

ATOM 1989 CA SER A 147 -8. 971 -27. 246 -73. ,545 1.00 31. 21 A c

ATOM 1991 CB SER A 147 -9. 208 -28. 296 -74. ,606 1.00 31. 60 A c

ATOM 1994 OG SER A 147 -8. 566 -27. 873 -75. ,801 1.00 29. 89 A 0

ATOM 1996 C SER A 147 -7. 512 -26. 806 -73. ,649 1.00 34. 49 A c

ATOM 1997 O SER A 147 -7. 188 -25. 830 -74. 329 1.00 33. 82 A 0

ATOM 1999 N HIS A 148 -6. 620 -27. ,546 -73. ,011 1.00 40. ,96 A N

ATOM 2000 CA HIS A 148 -5. 196 -27. ,218 -73. ,064 1.00 36. ,62 A C

ATOM 2002 CB HIS A 148 -4. 454 -27. ,890 -71. ,922 1.00 37. ,45 A C

ATOM 2005 CG HIS A 148 -4. 860 -27. 385 -70. 573 1.00 35. ,43 A c

ATOM 2006 NDl HIS A 148 -5. 642 -28. ,117 -69. 703 1.00 34. 93 A N

ATOM 2008 CEl HIS A 148 -5. 834 -27. ,417 -68. 599 1.00 36. ,86 A c

ATOM 2010 NE2 HIS A 148 -5. 209 -26. ,260 -68. 721 1.00 31. ,81 A N

ATOM 2012 CD2 HIS A 148 -4. 600 -26. ,213 -69. ,949 1.00 34. ,81 A c

ATOM 2014 C HIS A 148 -4. 554 -27. ,516 -74. 418 1.00 33. ,43 A C

ATOM 2015 O HIS A 148 -3. 572 -26. 868 -74. 772 1.00 33. ,76 A 0

ATOM 2017 N ALA A 149 -5. 123 -28. 457 -75. 175 1.00 35. ,18 A N

ATOM 2018 CA ALA A 149 -4. 736 -28. 700 -76. 579 1.00 41. ,68 A C

ATOM 2020 CB ALA A 149 -5. 564 -29. 879 -77. ,182 1.00 38. ,00 A C

ATOM 2024 C ALA A 149 -4. 876 -27. ,434 -77. ,454 1.00 44. ,39 A C

ATOM 2025 O ALA A 149 -4. 290 -27. ,342 -78. ,533 1.00 45. ,28 A 0

ATOM 2027 N GLY A 150 -5. 672 -26. ,477 -76. ,979 1.00 45. ,22 A N

ATOM 2028 CA GLY A 150 -5. 784 -25. ,151 -77. ,586 1.00 43. ,96 A C

ATOM 2031 C GLY A 150 -7. 001 -24. ,994 -78. ,477 1.00 43. ,10 A C

ATOM 2032 O GLY A 150 -6. 976 -24. 191 -79. ,415 1.00 38. ,65 A 0

ATOM 2034 N ARG A 151 -8. 066 -25. 752 -78. ,197 1.00 42. ,16 A N

ATOM 2035 CA ARG A 151 -9. 253 -25. 705 -79. 050 1.00 46. ,11 A C

ATOM 2037 CB ARG A 151 -10. 172 -26. 913 -78. ,869 1.00 45. ,34 A c cyno fD_Fab

ATOM 2040 CG ARG A 151 -11. ,349 -26. 822 -79. 812 1. 00 43. 91 A C

ATOM 2043 CD ARG A 151 -12. 289 -27. 973 -79. 709 1. 00 48. 15 A C

ATOM 2046 NE ARG A 151 -13. ,626 -27. 450 -79. 449 1. 00 53. 50 A N

ATOM 2048 CZ ARG A 151 -14. 305 -27. 591 -78. 312 1. 00 52. 84 A C

ATOM 2049 NHl ARG A 151 -13. ,819 -28. 302 -77. 286 1. 00 54. 12 A N

ATOM 2052 NH2 ARG A 151 -15. ,501 -27. 030 -78. 217 1. 00 47. 80 A N

ATOM 2055 C ARG A 151 -10. 055 -24. 423 -78. ,823 1. 00 45. 78 A C

ATOM 2056 O ARG A 151 -10. 424 -24. 097 -77. ,686 1. 00 36. 87 A 0

ATOM 2058 N ARG A 152 -10. ,319 -23. 725 -79. 925 1. 00 45. 20 A N

ATOM 2059 CA ARG A 152 -11. 080 -22. 493 -79. 907 1. 00 46. 08 A C

ATOM 2061 CB ARG A 152 -10. 538 -21.528 -80. 965 1. 00 49. 84 A C

ATOM 2064 CG ARG A 152 -9. 054 -21. 230 -80. 792 1. 00 50. 26 A c

ATOM 2067 CD ARG A 152 -8. 503 -20. 316 -81. 876 1. 00 54. 44 A c

ATOM 2070 NE ARG A 152 -7. ,066 -20. 531 -82. ,065 1. 00 58. 49 A N

ATOM 2072 CZ ARG A 152 -6. 222 -19. 685 -82. 668 1. 00 61. 42 A c

ATOM 2073 NHl ARG A 152 -6. 650 -18. 530 -83. ,178 1. 00 60. 62 A N

ATOM 2076 NH2 ARG A 152 -4. 925 -20. 004 -82. 763 1. 00 58. 93 A N

ATOM 2079 C ARG A 152 -12. 552 -22. 834 -80. 150 1. 00 44. 99 A C

ATOM 2080 O ARG A 152 -12. 874 -23. 509 -81. 129 1. 00 44. 36 A 0

ATOM 2082 N PRO A 153 -13. 449 -22. 409 -79. 234 1. 00 39. 93 A N

ATOM 2083 CA PRO A 153 -14. 860 -22. 629 -79. 461 1. 00 36. 36 A C

ATOM 2085 CB PRO A 153 -15. ,476 -22. 375 -78. 081 1. 00 36. 05 A C

ATOM 2088 CG PRO A 153 -14. 622 -21. 368 -77. ,492 1. 00 34. 25 A c

ATOM 2091 CD PRO A 153 -13. ,225 -21. 717 -77. ,953 1. 00 39. 12 A c

ATOM 2094 C PRO A 153 -15. ,411 -21. 644 -80. 481 1. 00 31. 32 A c

ATOM 2095 O PRO A 153 -14. 953 -20. 504 -80. 559 1. 00 34. 16 A 0

ATOM 2096 N ASP A 154 -16. 377 -22. 108 -81. 261 1. 00 30. 93 A N

ATOM 2097 CA ASP A 154 -17. 140 -21. 262 -82. 162 1. 00 30. 67 A c

ATOM 2099 CB ASP A 154 -17. 912 -22. 123 -83. 172 1. 00 25. 39 A c

ATOM 2102 CG ASP A 154 -18. ,667 -21. 299 -84. ,175 1. 00 26. 76 A c

ATOM 2103 ODl ASP A 154 -18. ,031 -20. 474 -84. ,851 1. 00 24. 57 A 0

ATOM 2104 OD2 ASP A 154 -19. ,901 -21. 462 -84. ,279 1. 00 27. 62 A 0

ATOM 2105 C ASP A 154 -18. ,123 -20. 403 -81. ,371 1. 00 28. 56 A c

ATOM 2106 O ASP A 154 -18. ,357 -19. 253 -81.712 1. 00 24. 83 A 0

ATOM 2108 N ARG A 155 -18. 712 -20. 975 -80. 328 1. 00 28. 26 A N

ATOM 2109 CA ARG A 155 -19. 768 -20. 293 -79. 596 1. 00 27. 71 A c

ATOM 2111 CB ARG A 155 -20. 991 -21.189 -79. 476 1. 00 29. 20 A c

ATOM 2114 CG ARG A 155 -21. ,708 -21. 304 -80. ,805 1. 00 33. 28 A c

ATOM 2117 CD ARG A 155 -22. 733 -22. 366 -80. ,813 1. 00 31.61 A c

ATOM 2120 NE ARG A 155 -22. ,134 -23. 666 -80. ,597 1. 00 33. 54 A N

ATOM 2122 CZ ARG A 155 -22. 827 -24. 794 -80. ,557 1. 00 35. 30 A c

ATOM 2123 NHl ARG A 155 -24. 147 -24. 782 -80. ,726 1. 00 39. 14 A N

ATOM 2126 NH2 ARG A 155 -22. 200 -25. 940 -80. ,349 1. 00 36. 27 A N

ATOM 2129 C ARG A 155 -19. 293 -19. 803 -78. ,249 1. 00 27. 25 A C

ATOM 2130 0 ARG A 155 -18. 368 -20. 352 -77. ,665 1. 00 31. 25 A 0

ATOM 2132 N LEU A 156 -19. ,927 -18. ,740 -77. ,775 1. 00 24. 85 A N

ATOM 2133 CA LEU A 156 -19. ,564 -18. 120 -76. ,514 1. 00 22. ,64 A C

ATOM 2135 CB LEU A 156 -20. ,396 -16. 860 -76. ,297 1. 00 23. ,90 A C

ATOM 2138 CG LEU A 156 -19. ,997 -16. 035 -75. 080 1. 00 22. 33 A C

ATOM 2140 CDl LEU A 156 -18. ,586 -15. 467 -75. 249 1. 00 13. 18 A C

ATOM 2144 CD2 LEU A 156 -21. ,001 -14. 969 -74. 927 1. 00 19. 84 A C

ATOM 2148 C LEU A 156 -19. 734 -19. 061 -75. ,315 1. 00 20. 76 A C

ATOM 2149 0 LEU A 156 -20. ,752 -19. 729 -75. ,169 1. 00 21.60 A 0

ATOM 2151 N GLN A 157 -18. ,723 -19. 070 -74. ,454 1. 00 23. ,15 A N

ATOM 2152 CA GLN A 157 -18. ,698 -19. 894 -73. ,263 1. 00 20. ,93 A C

ATOM 2154 CB GLN A 157 -17. ,459 -20. 783 -73. ,272 1. 00 21.93 A c

ATOM 2157 CG GLN A 157 -17. ,237 -21. 573 -74. ,560 1. 00 25. ,99 A c

ATOM 2160 CD GLN A 157 -18. ,204 -22. 726 -74. ,707 1. 00 26. 63 A c

ATOM 2161 OEl GLN A 157 -18. ,390 -23. 509 -73. ,779 1. 00 31. ,72 A 0

ATOM 2162 NE2 GLN A 157 -18. ,829 -22. 838 -75. ,877 1. 00 27. ,16 A N

ATOM 2165 C GLN A 157 -18. ,649 -18. 991 -72. ,049 1. 00 15. 50 A c

ATOM 2166 0 GLN A 157 -18. ,204 -17. ,865 -72. ,128 1. 00 16. ,34 A 0

ATOM 2168 N HIS A 158 -19. ,082 -19. 501 -70. ,914 1. 00 19. ,52 A N

ATOM 2169 CA HIS A 158 -18. ,996 -18. 735 -69. ,673 1. 00 19. ,83 A c

ATOM 2171 CB HIS A 158 -20. 266 -17. ,901 -69. ,457 1. 00 20. ,54 A c

ATOM 2174 CG HIS A 158 -21. ,379 -18. ,677 -68. ,832 1. 00 22. ,61 A c

ATOM 2175 NDl HIS A 158 -22. ,038 -19. 680 -69. ,502 1. 00 20. ,53 A N

ATOM 2177 CEl HIS A 158 -22. ,951 -20. 207 -68. ,710 1. 00 23. ,64 A c cyno fD_Fab

ATOM 2179 NE2 HIS A 158 -22. 891 -19. 598 -67. ,540 1.00 23. ,00 A N

ATOM 2181 CD2 HIS A 158 -21. ,916 -18. 637 -67. ,589 1.00 22. 29 A C

ATOM 2183 C HIS A 158 -18. 820 -19. 692 -68. ,518 1.00 17. ,38 A C

ATOM 2184 O HIS A 158 -18. ,979 -20. 904 -68. ,671 1.00 17. ,10 A 0

ATOM 2186 N VAL A 159 -18. ,477 -19. 135 -67. 364 1.00 20. ,26 A N

ATOM 2187 CA VAL A 159 -18. ,309 -19. 919 -66. 149 1.00 17. ,49 A c

ATOM 2189 CB VAL A 159 -16. ,964 -20. 788 -66. ,155 1.00 18. ,10 A c

ATOM 2191 CGI VAL A 159 -15. ,686 -19. 944 -66. ,109 1.00 8. ,59 A c

ATOM 2195 CG2 VAL A 159 -16. ,982 -21. 863 -65. ,010 1.00 16. ,09 A c

ATOM 2199 C VAL A 159 -18. ,463 -18. 994 -64. 948 1.00 18. ,69 A c

ATOM 2200 O VAL A 159 -18. ,087 -17. 821 -64. 996 1.00 16. ,96 A 0

ATOM 2202 N LEU A 160 -19. 101 -19. 507 -63. ,902 1.00 19. ,74 A N

ATOM 2203 CA LEU A 160 -19. 296 -18. 762 -62. 671 1.00 19. ,02 A c

ATOM 2205 CB LEU A 160 -20. 680 -19. 111 -62. 105 1.00 19. ,54 A c

ATOM 2208 CG LEU A 160 -21. ,446 -18. 129 -61. 229 1.00 19. 36 A c

ATOM 2210 CDl LEU A 160 -21. 603 -16. 742 -61. 912 1.00 16. 65 A c

ATOM 2214 CD2 LEU A 160 -22. 825 -18. 760 -60. 875 1.00 13. 16 A c

ATOM 2218 C LEU A 160 -18. 162 -19. 100 -61. ,681 1.00 19. ,79 A c

ATOM 2219 O LEU A 160 -18. 045 -20. 233 -61. 235 1.00 24. 92 A 0

ATOM 2221 N LEU A 161 -17. 330 -18. 112 -61. 354 1.00 18. ,59 A N

ATOM 2222 CA LEU A 161 -16. ,133 -18. 305 -60. 536 1.00 21.76 A c

ATOM 2224 CB LEU A 161 -14. ,888 -17. 804 -61. 282 1.00 23. 47 A c

ATOM 2227 CG LEU A 161 -14. ,426 -18. 440 -62. 597 1.00 21. 99 A c

ATOM 2229 CDl LEU A 161 -13. 130 -17. 766 -63. 064 1.00 18. 36 A c

ATOM 2233 CD2 LEU A 161 -14. 222 -19. 911 -62. 439 1.00 22. 70 A c

ATOM 2237 C LEU A 161 -16. 220 -17. 560 -59. 187 1.00 24. 45 A c

ATOM 2238 O LEU A 161 -16. 679 -16. 415 -59. 129 1.00 25. 20 A 0

ATOM 2240 N PRO A 162 -15. 775 -18. 204 -58. 095 1.00 24. 12 A N

ATOM 2241 CA PRO A 162 -15. 684 -17. 481 -56. 806 1.00 19. ,46 A c

ATOM 2243 CB PRO A 162 -15. 664 -18. 598 -55. 757 1.00 20. 25 A c

ATOM 2246 CG PRO A 162 -15. ,349 -19. 895 -56. 520 1.00 20. ,47 A c

ATOM 2249 CD PRO A 162 -15. 348 -19. 613 -57. 998 1.00 20. 78 A c

ATOM 2252 C PRO A 162 -14. 441 -16. 574 -56. 675 1.00 18. 90 A c

ATOM 2253 O PRO A 162 -13. 322 -16. 970 -57. 013 1.00 20. 24 A 0

ATOM 2254 N VAL A 163 -14. 659 -15. 356 -56. 191 1.00 21. 80 A N

ATOM 2255 CA VAL A 163 -13. 585 -14. 404 -55. 975 1.00 20.89 A c

ATOM 2257 CB VAL A 163 -14. 168 -12. 982 -55. 760 1.00 21. 63 A c

ATOM 2259 CGI VAL A 163 -13. 136 -12. 010 -55. 234 1.00 20. 25 A c

ATOM 2263 CG2 VAL A 163 -14. 730 -12. 459 -57. ,074 1.00 19. ,97 A c

ATOM 2267 C VAL A 163 -12. ,658 -14. 905 -54. ,829 1.00 24. ,06 A c

ATOM 2268 0 VAL A 163 -13. ,119 -15. 367 -53. ,782 1.00 26. ,39 A 0

ATOM 2270 N LEU A 164 -11.353 -14. 854 -55. 078 1.00 20. ,04 A N

ATOM 2271 CA LEU A 164 -10. 340 -15. 294 -54. ,142 1.00 20. ,58 A c

ATOM 2273 CB LEU A 164 -9. 289 -16. 133 -54. ,881 1.00 18. ,41 A c

ATOM 2276 CG LEU A 164 -8. 174 -16. 813 -54. 084 1.00 20. ,38 A c

ATOM 2278 CDl LEU A 164 -8. 716 -17. 893 -53. ,142 1.00 17. ,03 A c

ATOM 2282 CD2 LEU A 164 -7. 145 -17. 395 -55. ,055 1.00 21. ,63 A c

ATOM 2286 C LEU A 164 -9. 710 -14. 035 -53. ,563 1.00 20. ,51 A c

ATOM 2287 O LEU A 164 -9. 264 -13. 168 -54. 311 1.00 24. 96 A 0

ATOM 2289 N ASP A 165 -9. 682 -13. 939 -52. 233 1.00 20. 22 A N

ATOM 2290 CA ASP A 165 -9. 082 -12. 805 -51. ,553 1.00 17. ,69 A c

ATOM 2292 CB ASP A 165 -9. 136 -12. 999 -50. ,038 1.00 23. ,18 A C

ATOM 2295 CG ASP A 165 -8. 150 -14. 022 -49. ,545 1.00 29. ,87 A c

ATOM 2296 ODl ASP A 165 -7. 026 -13. 628 -49. ,160 1.00 30. ,87 A 0

ATOM 2297 OD2 ASP A 165 -8. 491 -15. 218 -49. ,563 1.00 34. ,33 A 0

ATOM 2298 C ASP A 165 -7. 628 -12. 529 -52. ,019 1.00 22. ,45 A c

ATOM 2299 O ASP A 165 -6. 926 -13. 422 -52. ,479 1.00 20. ,10 A 0

ATOM 2301 N ARG A 166 -7. 180 -11. 288 -51. ,868 1.00 21. ,60 A N

ATOM 2302 CA ARG A 166 -5. 911 -10. 868 -52. ,440 1.00 22. ,03 A c

ATOM 2304 CB ARG A 166 -5. 831 -9. 334 -52. ,470 1.00 19. ,86 A c

ATOM 2307 CG ARG A 166 -4. 674 -8. 815 -53. ,308 1.00 24. ,19 A c

ATOM 2310 CD ARG A 166 -4. 748 -7. ,303 -53. ,491 1.00 24. ,63 A c

ATOM 2313 NE ARG A 166 -5. 852 -6. 904 -54. ,349 1.00 26. ,26 A N

ATOM 2315 cz ARG A 166 -7. ,007 -6. 389 -53. 932 1.00 21. 16 A c

ATOM 2316 NHl ARG A 166 -7. 269 -6. 191 -52. ,644 1.00 18. 22 A N

ATOM 2319 NH2 ARG A 166 -7. 924 -6. 077 -54. 827 1.00 26. 25 A N

ATOM 2322 C ARG A 166 -4. 694 -11.474 -51.732 1.00 18. ,59 A C

ATOM 2323 O ARG A 166 -3. 690 -11. 749 -52. ,382 1.00 21. 13 A 0 cyno fD_Fab

ATOM 2325 N ALA A 167 -4.804 -11. ,703 -50. ,421 1.00 18. ,53 A N

ATOM 2326 CA ALA A 167 -3. 698 -12. ,192 -49. ,593 1.00 18. ,47 A C

ATOM 2328 CB ALA A 167 -4. 014 -12. ,059 -48. ,096 1.00 19. ,96 A C

ATOM 2332 C ALA A 167 -3. 381 -13. 638 -49. ,964 1.00 21. ,72 A c

ATOM 2333 O ALA A 167 -2. 213 -13. ,983 -50. ,253 1.00 24. ,85 A 0

ATOM 2335 N THR A 168 -4. 415 -14. 472 -50. ,036 1.00 20. ,26 A N

ATOM 2336 CA THR A 168 -4. 233 -15. 822 -50. ,577 1.00 20. ,44 A c

ATOM 2338 CB THR A 168 -5. 558 -16. 565 -50. ,694 1.00 18. ,81 A c

ATOM 2340 OGl THR A 168 -6. 097 -16. ,784 -49. ,384 1.00 22. ,97 A 0

ATOM 2342 CG2 THR A 168 -5. 367 -17. ,902 -51. .405 1.00 21. ,73 A c

ATOM 2346 C THR A 168 -3. 584 -15. ,764 -51. ,962 1.00 23. ,35 A c

ATOM 2347 O THR A 168 -2. 629 -16. 490 -52. ,244 1.00 21. ,77 A 0

ATOM 2349 N CYS A 169 -4. 092 -14. 877 -52. ,814 1.00 24. ,99 A N

ATOM 2350 CA CYS A 169 -3. 619 -14. 776 -54. 195 1.00 22. ,71 A c

ATOM 2352 CB CYS A 169 -4. 552 -13. 843 -54. 990 1.00 22. 88 A c

ATOM 2355 SG CYS A 169 -4. 419 -14. 130 -56. ,761 1.00 29. ,22 A s

ATOM 2357 C CYS A 169 -2. 153 -14. 312 -54. ,318 1.00 21. ,42 A c

ATOM 2358 O CYS A 169 -1. 479 -14. 572 -55. ,338 1.00 23. ,65 A 0

ATOM 2360 N ASN A 170 -1. 671 -13. 610 -53. ,291 1.00 23. .92 A N

ATOM 2361 CA ASN A 170 -0. 285 -13. ,138 -53. ,235 1.00 23. ,63 A c

ATOM 2363 CB ASN A 170 -0. 211 -11. ,745 -52. ,594 1.00 18. ,85 A c

ATOM 2366 CG ASN A 170 -0. 416 -10. 632 -53. ,600 1.00 22. ,74 A c

ATOM 2367 ODl ASN A 170 0. 032 -10. 728 -54. ,756 1.00 19. ,40 A 0

ATOM 2368 ND2 ASN A 170 -1. 062 -9. 559 -53. ,168 1.00 18. ,56 A N

ATOM 2371 C ASN A 170 0. 722 -14. 084 -52. ,547 1.00 24. ,40 A c

ATOM 2372 O ASN A 170 1. 924 -13. 848 -52. ,619 1.00 22. ,92 A 0

ATOM 2374 N ARG A 171 0. 241 -15. 128 -51. ,882 1.00 25. ,33 A N

ATOM 2375 CA ARG A 171 1. 110 -16. 222 -51. ,426 1.00 23. ,63 A c

ATOM 2377 CB ARG A 171 0. 287 -17. ,454 -51. ,058 1.00 23. ,21 A c

ATOM 2380 CG ARG A 171 0. 151 -17. ,676 -49. ,568 1.00 27. ,77 A c

ATOM 2383 CD ARG A 171 -0. 382 -19. ,038 -49. ,251 1.00 31. ,54 A c

ATOM 2386 NE ARG A 171 -1. 774 -18. ,912 -48. ,863 1.00 37. ,50 A N

ATOM 2388 CZ ARG A 171 -2. 766 -19. ,709 -49. ,246 1.00 39. ,05 A C

ATOM 2389 NHl ARG A 171 -3. 999 -19. 451 -48. ,809 1.00 43. ,84 A N

ATOM 2392 NH2 ARG A 171 -2. 561 -20. ,739 -50. ,055 1.00 31. ,78 A N

ATOM 2395 C ARG A 171 2. 105 -16. 597 -52. ,513 1.00 22. ,78 A C

ATOM 2396 0 ARG A 171 1. 755 -16. 570 -53. ,686 1.00 21. ,17 A 0

ATOM 2398 N ARG A 172 3. 338 -16. 955 -52. ,130 1.00 22. ,43 A N

ATOM 2399 CA ARG A 172 4. 387 -17. ,213 -53. ,120 1.00 26. ,74 A C

ATOM 2401 CB ARG A 172 5. 739 -17. ,486 -52. ,434 1.00 27. ,50 A C

ATOM 2404 CG ARG A 172 5. 820 -18. ,800 -51. ,691 1.00 25. ,13 A c

ATOM 2407 CD ARG A 172 7. 087 -18. ,888 -50. ,893 1.00 27. ,27 A c

ATOM 2410 NE ARG A 172 6. 951 -18. ,209 -49. ,608 1.00 27. ,02 A N

ATOM 2412 CZ ARG A 172 7. 958 -18. ,014 -48. ,768 1.00 25. ,71 A c

ATOM 2413 NHl ARG A 172 9. 198 -18. ,406 -49. ,085 1.00 20. ,19 A N

ATOM 2416 NH2 ARG A 172 7. 729 -17. ,387 -47. ,617 1.00 28. ,46 A N

ATOM 2419 C ARG A 172 4. 039 -18. ,349 -54. ,076 1.00 24. ,36 A c

ATOM 2420 0 ARG A 172 4. 496 -18. ,356 -55. ,228 1.00 25. ,99 A 0

ATOM 2422 N THR A 173 3. 229 -19. ,301 -53. .607 1.00 25. ,42 A N

ATOM 2423 CA THR A 173 2. 751 -20. ,392 -54. ,473 1.00 25. ,47 A c

ATOM 2425 CB THR A 173 1. 818 -21. 346 -53. .729 1.00 20. ,22 A c

ATOM 2427 OGl THR A 173 2. 294 -21.552 -52. ,398 1.00 16. ,95 A 0

ATOM 2429 CG2 THR A 173 1. 740 -22. 673 -54. ,457 1.00 23. ,50 A c

ATOM 2433 C THR A 173 1. 943 -19. 881 -55. ,654 1.00 27, ,26 A c

ATOM 2434 0 THR A 173 1. 870 -20. 535 -56, ,703 1.00 26. ,37 A 0

ATOM 2436 N HIS A 174 1. 310 -18. ,724 -55, ,453 1.00 27. ,47 A N

ATOM 2437 CA HIS A 174 0. 382 -18. ,149 -56. ,402 1.00 25. ,23 A c

ATOM 2439 CB HIS A 174 -0. 921 -17. ,803 -55, ,685 1.00 25. ,54 A c

ATOM 2442 CG HIS A 174 -1. 526 -18. ,982 -55. .002 1.00 22, .85 A c

ATOM 2443 NDl HIS A 174 -2. 237 -18. ,885 -53. ,830 1.00 24. .48 A N

ATOM 2445 CEl HIS A 174 -2. 634 -20. ,092 -53. ,458 1.00 24. .84 A c

ATOM 2447 NE2 HIS A 174 -2. 199 -20. ,967 -54. .344 1.00 24, ,16 A N

ATOM 2449 CD2 HIS A 174 -1. 480 -20. ,302 -55, .307 1.00 20. .64 A c

ATOM 2451 C HIS A 174 1. 033 -16. ,994 -57, ,119 1.00 26. .13 A c

ATOM 2452 0 HIS A 174 1. 945 -17. ,217 -57. ,913 1.00 29, ,10 A 0

ATOM 2454 N HIS A 175 0. 605 -15. ,765 -56. ,871 1.00 30, ,72 A N

ATOM 2455 CA HIS A 175 1. 133 -14. ,671 -57. ,666 1.00 25. ,85 A c

ATOM 2457 CB HIS A 175 -0. 019 -13. ,890 -58. ,284 1.00 25, ,40 A c cyno fD_Fab

ATOM 2460 CG HIS A 175 -0. ,761 -14. 677 -59. ,314 1.00 27. 33 A C

ATOM 2461 NDl HIS A 175 -0. ,156 -15. 154 -60. ,462 1.00 25. 47 A N

ATOM 2463 CEl HIS A 175 -1. 046 -15. 812 -61.179 1.00 25. 76 A C

ATOM 2465 NE2 HIS A 175 -2. 203 -15. 787 -60. 537 1.00 28. 33 A N

ATOM 2467 CD2 HIS A 175 -2. ,048 -15. 095 -59. 362 1.00 23. 27 A C

ATOM 2469 C HIS A 175 2. ,170 -13. 809 -56. ,968 1.00 26. ,70 A C

ATOM 2470 0 HIS A 175 2. ,669 -12. 857 -57. ,571 1.00 30. 20 A 0

ATOM 2472 N ASP A 176 2. 493 -14. 145 -55. ,713 1.00 26. 66 A N

ATOM 2473 CA ASP A 176 3. ,762 -13. 757 -55. 105 1.00 25. 62 A c

ATOM 2475 CB ASP A 176 4. 916 -14. 398 -55. ,909 1.00 26. 96 A c

ATOM 2478 CG ASP A 176 6. 195 -14. 591 -55. ,095 1.00 25. 57 A c

ATOM 2479 001 ASP A 176 6. ,221 -14. 332 -53. 870 1.00 21. 71 A 0

ATOM 2480 002 ASP A 176 7. 201 -15. 026 -55. 705 1.00 27. 90 A 0

ATOM 2481 C ASP A 176 3. 924 -12. 229 -55. 035 1.00 25. 46 A c

ATOM 2482 0 ASP A 176 4. 996 -11. 695 -55. 336 1.00 23. 03 A 0

ATOM 2484 N GLY A 177 2. ,847 -11. 551 -54. ,647 1.00 21. 78 A N

ATOM 2485 CA GLY A 177 2. 822 -10. 096 -54. ,454 1.00 20. 61 A c

ATOM 2488 C GLY A 177 2. 427 -9. 257 -55. 662 1.00 22. ,71 A c

ATOM 2489 0 GLY A 177 2. ,288 -8. 042 -55. ,544 1.00 26. 55 A 0

ATOM 2491 N ALA A 178 2. 275 -9. 901 -56. 819 1.00 26. ,13 A N

ATOM 2492 CA ALA A 178 1. 990 -9. 237 -58. 106 1.00 25. 28 A c

ATOM 2494 CB ALA A 178 2. 232 -10. 228 -59. 278 1.00 24. 14 A c

ATOM 2498 C ALA A 178 0. 581 -8. 654 -58. 200 1.00 27. 53 A c

ATOM 2499 0 ALA A 178 0. 330 -7. 779 -59. 030 1.00 30. 65 A 0

ATOM 2501 N ILE A 179 -0. ,326 -9. 131 -57. 342 1.00 26. ,84 A N

ATOM 2502 CA ILE A 179 -1. 707 -8. 644 -57. 298 1.00 27. ,21 A c

ATOM 2504 CB ILE A 179 -2. 703 -9. 723 -56. 756 1.00 23. ,00 A c

ATOM 2506 CGl ILE A 179 -2. ,406 -11. 109 -57. 360 1.00 20. 36 A c

ATOM 2509 CDl ILE A 179 -2. ,091 -11.124 -58. ,878 1.00 17. 33 A c

ATOM 2513 CG2 ILE A 179 -4. 161 -9. 290 -56. 997 1.00 18. ,33 A c

ATOM 2517 C ILE A 179 -1. 798 -7. 384 -56. ,430 1.00 27. ,98 A c

ATOM 2518 0 ILE A 179 -1. 788 -7. 452 -55. 193 1.00 31. 45 A 0

ATOM 2520 N THR A 180 -1. 891 -6. 242 -57. 103 1.00 25. 23 A N

ATOM 2521 CA THR A 180 -1. ,995 -4. 940 -56. ,457 1.00 29. ,01 A c

ATOM 2523 CB THR A 180 -1. ,479 -3. 796 -57. ,367 1.00 30. ,06 A c

ATOM 2525 OGl THR A 180 -2. 406 -3. 560 -58. ,436 1.00 31. ,95 A 0

ATOM 2527 CG2 THR A 180 -0. ,107 -4. 103 -57. 933 1.00 29. ,98 A c

ATOM 2531 C THR A 180 -3. ,446 -4. 656 -56. ,120 1.00 29. ,88 A c

ATOM 2532 0 THR A 180 -4. 330 -5. 477 -56. ,371 1.00 30. ,84 A 0

ATOM 2534 N GLN A 181 -3. 685 -3. 476 -55. ,559 1.00 32. ,25 A N

ATOM 2535 CA GLN A 181 -5. 034 -3. 024 -55. ,230 1.00 27. ,50 A c

ATOM 2537 CB GLN A 181 -4. 987 -1. 709 -54. ,447 1.00 34. 08 A c

ATOM 2540 CG GLN A 181 -6. ,148 -1. 521 -53. ,494 1.00 34. ,95 A c

ATOM 2543 CD GLN A 181 -6. ,038 -2. 398 -52. ,263 1.00 38. ,74 A c

ATOM 2544 OEl GLN A 181 -6. ,990 -2. 542 -51. ,496 1.00 41. ,65 A 0

ATOM 2545 NE2 GLN A 181 -4. ,877 -2. 999 -52. ,075 1.00 38. ,41 A N

ATOM 2548 C GLN A 181 -5. ,914 -2. 821 -56. ,445 1.00 20. ,22 A c

ATOM 2549 0 GLN A 181 -7. ,123 -2. 827 -56. ,308 1.00 21. 70 A 0

ATOM 2551 N ARG A 182 -5. ,315 -2. 658 -57. ,624 1.00 20. ,91 A N

ATOM 2552 CA ARG A 182 -6. ,045 -2. 409 -58. ,865 1.00 26. 89 A ^¾ c

ATOM 2554 CB ARG A 182 -5. 249 -1. 506 -59. ,836 1.00 35. ,06 A c

ATOM 2557 CG ARG A 182 -4. 269 -0. 490 -59. ,232 1.00 40. ,34 A c

ATOM 2560 CD ARG A 182 -4. ,904 0. ,784 -58. ,736 1.00 47. .01 A c

ATOM 2563 NE ARG A 182 -5. ,192 1. 755 -59. ,798 1.00 52. ,05 A N

ATOM 2565 cz ARG A 182 -4. 282 2. ,453 -60. ,484 1.00 53. ,87 A c

ATOM 2566 NHl ARG A 182 -2. ,975 2. 309 -60. ,252 1.00 56. ,05 A N

ATOM 2569 NH2 ARG A 182 -4. ,691 3. 309 -61. ,424 1.00 51. ,91 A N

ATOM 2572 C ARG A 182 -6. ,390 -3. 722 -59. ,581 1.00 29. .98 A c

ATOM 2573 0 ARG A 182 -6. 832 -3. 707 -60. ,729 1.00 32. ,16 A 0

ATOM 2575 N MET A 183 -6. ,186 -4. 846 -58. ,892 1.00 29. ,84 A N

ATOM 2576 CA MET A 183 -6. ,292 -6. 172 -59. ,472 1.00 26. 68 A C

ATOM 2578 CB MET A 183 -4. ,897 -6. ,777 -59. ,653 1.00 26. .85 A C

ATOM 2581 CG MET A 183 -4. ,232 -6. ,455 -60. ,984 1.00 32. ,53 A c

ATOM 2584 SD MET A 183 -2. ,451 -6. ,812 -60. ,976 1.00 32. ,78 A S

ATOM 2585 CE MET A 183 -1. ,938 -5. ,348 -60. ,168 1.00 38. ,11 A c

ATOM 2589 C MET A 183 -7. ,106 -7. 035 -58. ,534 1.00 21.15 A c

ATOM 2590 0 MET A 183 -7. ,202 -6. 750 -57. ,347 1.00 23. ,07 A 0

ATOM 2592 N MET A 184 -7. ,723 -8. 074 -59. ,071 1.00 24. .53 A N cyno fD_Fab

ATOM 2593 CA MET A 184 -8.439 -9. ,043 -58. 246 1.00 21. ,72 A C

ATOM 2595 CB MET A 184 -9. ,940 -8. ,730 -58. ,176 1.00 23. ,03 A C

ATOM 2598 CG MET A 184 -10. ,701 -8. ,730 -59. 488 1.00 20. ,18 A C

ATOM 2601 SD MET A 184 -12. ,399 -8. ,201 -59. 244 1.00 23. ,38 A s

ATOM 2602 CE MET A 184 -13. ,061 -9. ,551 -58. 270 1.00 21. ,93 A C

ATOM 2606 C MET A 184 -8. 200 -10. ,441 -58. 777 1.00 23. ,48 A c

ATOM 2607 O MET A 184 -7. 687 -10. ,620 -59. 881 1.00 18. ,50 A 0

ATOM 2609 N CYS A 185 -8. 568 -11. ,428 -57. 973 1.00 21. ,58 A N

ATOM 2610 CA CYS A 185 -8. 350 -12. ,818 -58. 324 1.00 26. ,00 A c

ATOM 2612 CB CYS A 185 -7. 278 -13. ,437 -57. 412 1.00 31.71 A c

ATOM 2615 SG CYS A 185 -5. 646 -12. 784 -57. 675 1.00 35. ,37 A s

ATOM 2617 C CYS A 185 -9. 642 -13. ,611 -58. 226 1.00 23. ,36 A c

ATOM 2618 O CYS A 185 -10. 589 -13. 202 -57. 532 1.00 23. ,41 A 0

ATOM 2620 N ALA A 186 -9. 671 -14. 727 -58. 961 1.00 21. 25 A N

ATOM 2621 CA ALA A 186 -10. 721 -15. ,730 -58. 852 1.00 18. ,39 A C

ATOM 2623 CB ALA A 186 -11. 699 -15. 600 -60. 012 1.00 22. ,22 A C

ATOM 2627 C ALA A 186 -10. 088 -17. ,104 -58. 859 1.00 20. 74 A c

ATOM 2628 O ALA A 186 -8. 984 -17. 284 -59. 374 1.00 19. 79 A 0

ATOM 2630 N GLU A 187 -10. 796 -18. ,088 -58. 319 1.00 20. 89 A N

ATOM 2631 CA GLU A 187 -10. 319 -19. ,469 -58. 359 1.00 23. ,28 A c

ATOM 2633 CB GLU A 187 -11. 232 -20. 392 -57. 559 1.00 28. ,66 A c

ATOM 2636 CG GLU A 187 -11.140 -20. ,077 -56. 050 1.00 31. ,43 A c

ATOM 2639 CD GLU A 187 -11. 985 -20. ,964 -55. 182 1.00 35. ,27 A c

ATOM 2640 OEl GLU A 187 -12. 169 -22. ,146 -55. 529 1.00 48. ,59 A 0

ATOM 2641 OE2 GLU A 187 -12. 454 -20. ,483 -54. 131 1.00 34. 82 A 0

ATOM 2642 C GLU A 187 -10. 115 -19. 938 -59. 805 1.00 26. 50 A c

ATOM 2643 O GLU A 187 -10. 758 -19. 441 -60. 735 1.00 20. 38 A 0

ATOM 2645 N SER A 188 -9. 136 -20. 836 -59. 971 1.00 23. 92 A N

ATOM 2646 CA SER A 188 -8. 702 -21. ,327 -61. 261 1.00 25. ,93 A c

ATOM 2648 CB SER A 188 -7. 293 -20. ,829 -61. 523 1.00 17. 83 A c

ATOM 2651 OG SER A 188 -6. 489 -21. ,092 -60. 398 1.00 21. 89 A 0

ATOM 2653 C SER A 188 -8. 710 -22. ,855 -61. 372 1.00 26. 38 A c

ATOM 2654 O SER A 188 -8. 414 -23. ,369 -62. 426 1.00 26. ,77 A 0

ATOM 2656 N ASN A 189 -9. 082 -23. 563 -60. 310 1.00 26. 10 A N

ATOM 2657 CA ASN A 189 -8. 947 -25. ,018 -60. 261 1.00 29. 58 A c

ATOM 2659 CB ASN A 189 -9. 152 -25. 510 -58. 824 1.00 32. 74 A c

ATOM 2662 CG ASN A 189 -8. 847 -26. 996 -58. 637 1.00 33. 31 A c

ATOM 2663 ODl ASN A 189 -8. 159 -27. 628 -59. 436 1.00 37. 29 A 0

ATOM 2664 ND2 ASN A 189 -9. 346 -27. ,546 -57. 545 1.00 38. ,45 A N

ATOM 2667 C ASN A 189 -9. 934 -25. ,684 -61. 193 1.00 28. 30 A c

ATOM 2668 O ASN A 189 -11. 114 -25. ,785 -60. 884 1.00 20. ,07 A 0

ATOM 2670 N ARG A 190 -9. 441 -26. ,090 -62. 361 1.00 30. ,01 A N

ATOM 2671 CA ARG A 190 -10. 248 -26. ,781 -63. 379 1.00 37. ,30 A C

ATOM 2673 CB ARG A 190 -10. 757 -28. ,134 -62. 830 1.00 42. ,30 A C

ATOM 2676 CG ARG A 190 -9. 616 -29. ,097 -62. 471 1.00 46. ,77 A c

ATOM 2679 CD ARG A 190 -10. 119 -30. ,494 -62. 133 1.00 50. ,54 A c

ATOM 2682 NE ARG A 190 -10. 941 -30. ,508 -60. 918 1.00 56. ,85 A N

ATOM 2684 CZ ARG A 190 -10. 511 -30. ,804 -59. 684 1.00 59. 99 A c

ATOM 2685 NHl ARG A 190 -9. 238 -31. ,129 -59. 453 1.00 61.53 A N

ATOM 2688 NH2 ARG A 190 -11.372 -30. ,782 -58. 662 1.00 57. ,81 A N

ATOM 2691 C ARG A 190 -11. 397 -25. 945 -63. 995 1.00 35. ,38 A c

ATOM 2692 0 ARG A 190 -12. 159 -26. 449 -64. 823 1.00 31. ,83 A 0

ATOM 2694 N ARG A 191 -11.478 -24. 669 -63. 608 1.00 35. ,99 A N

ATOM 2695 CA ARG A 191 -12. 500 -23. ,719 -64. 050 1.00 30. ,67 A C

ATOM 2697 CB ARG A 191 -13. 650 -23. 645 -63. 052 1.00 36. ,05 A c

ATOM 2700 CG ARG A 191 -14. 632 -24. 776 -63. 118 1.00 38. ,16 A c

ATOM 2703 CD ARG A 191 -15. 946 -24. 326 -62. 513 1.00 44. ,34 A c

ATOM 2706 NE ARG A 191 -16. 960 -25. ,377 -62. 505 1.00 47. ,89 A N

ATOM 2708 CZ ARG A 191 -17. 248 -26. ,166 -61. 466 1.00 56. ,46 A C

ATOM 2709 NHl ARG A 191 -16. 593 -26. ,054 -60. 305 1.00 57. ,52 A N

ATOM 2712 NH2 ARG A 191 -18. 210 -27. ,089 -61. 587 1.00 54. ,56 A N

ATOM 2715 C ARG A 191 -11. 825 -22. ,370 -64. 082 1.00 23. ,20 A C

ATOM 2716 0 ARG A 191 -11. 465 -21. ,857 -63. 041 1.00 27. ,82 A 0

ATOM 2718 N ASP A 192 -11. 636 -21. ,789 -65. 259 1.00 21. ,33 A N

ATOM 2719 CA ASP A 192 -10. 757 -20. ,650 -65. 363 1.00 19. ,68 A C

ATOM 2721 CB ASP A 192 -9. 303 -21.154 -65. 291 1.00 21. ,43 A C

ATOM 2724 CG ASP A 192 -8. 324 -20. ,096 -64. 865 1.00 16. ,40 A c

ATOM 2725 ODl ASP A 192 -8. 727 -18. ,938 -64. 626 1.00 25. ,12 A 0 cyno fD_Fab

ATOM 2726 OD2 ASP A 192 -7. ,122 -20. 425 -64. 787 1.00 26. 56 A 0

ATOM 2727 C ASP A 192 -10. 986 -19. ,880 -66. 652 1.00 19. 25 A C

ATOM 2728 O ASP A 192 -11. 582 -20. ,398 -67. 591 1.00 22. 47 A 0

ATOM 2730 N SER A 193 -10. ,539 -18. ,627 -66. 679 1.00 22. 34 A N

ATOM 2731 CA SER A 193 -10. 385 -17. ,891 -67. 926 1.00 27. 08 A C

ATOM 2733 CB SER A 193 -10. ,510 -16. ,375 -67. 698 1.00 26. 57 A C

ATOM 2736 OG SER A 193 -9. ,852 -15. ,967 -66. 518 1.00 31. 62 A 0

ATOM 2738 C SER A 193 -9. 034 -18. ,284 -68. 537 1.00 29. 35 A c

ATOM 2739 O SER A 193 -8. ,090 -18. ,610 -67. 816 1.00 28. 41 A 0

ATOM 2741 N CYS A 194 -8. ,964 -18. ,329 -69. 867 1.00 35. 46 A N

ATOM 2742 CA CYS A 194 -7. 765 -18. ,811 -70. 559 1.00 35. 62 A c

ATOM 2744 CB CYS A 194 -7. 983 -20. ,246 -71. 085 1.00 38. 72 A c

ATOM 2747 SG CYS A 194 -8. 598 -21. 459 -69. 858 1.00 37. 64 A S

ATOM 2749 C CYS A 194 -7. 365 -17. ,882 -71. 706 1.00 36. 97 A c

ATOM 2750 O CYS A 194 -7. 949 -16. ,826 -71. 893 1.00 31.60 A 0

ATOM 2752 N LYS A 195 -6. 349 -18. ,290 -72. 457 1.00 37. 38 A N

ATOM 2753 CA LYS A 195 -5. ,914 -17. ,586 -73. 656 1.00 38. 74 A C

ATOM 2755 CB LYS A 195 -4. ,797 -18. ,384 -74. 344 1.00 43. 77 A C

ATOM 2758 CG LYS A 195 -4. 022 -17. ,661 -75. 427 1.00 44. 77 A C

ATOM 2761 CD LYS A 195 -3. 308 -18. ,689 -76. 302 1.00 47. 51 A C

ATOM 2764 CE LYS A 195 -2. 601 -18. ,066 -77. 516 1.00 51. 32 A C

ATOM 2767 NZ LYS A 195 -1. 957 -19. 118 -78. 381 1.00 50. 65 A N

ATOM 2771 C LYS A 195 -7. 093 -17. 389 -74. 602 1.00 34. 36 A C

ATOM 2772 0 LYS A 195 -7. 845 -18. 330 -74. 881 1.00 33. 82 A 0

ATOM 2774 N GLY A 196 -7. 260 -16. ,143 -75. 053 1.00 34. 33 A N

ATOM 2775 CA GLY A 196 -8. 396 -15. ,729 -75. 868 1.00 31. 57 A C

ATOM 2778 C GLY A 196 -9. 537 -15. 115 -75. 060 1.00 31. 48 A c

ATOM 2779 O GLY A 196 -10. 438 -14. ,515 -75. 638 1.00 25. 54 A 0

ATOM 2781 N ASP A 197 -9. 501 -15. 286 -73. 732 1.00 29. 85 A N

ATOM 2782 CA ASP A 197 -10. 484 -14. 698 -72. 822 1.00 27. 11 A c

ATOM 2784 CB ASP A 197 -10. 752 -15. 632 -71. 640 1.00 25. 09 A c

ATOM 2787 CG ASP A 197 -11. 451 -16. 915 -72. 058 1.00 25. 05 A c

ATOM 2788 ODl ASP A 197 -12. 324 -16. 856 -72. 943 1.00 19. 95 A 0

ATOM 2789 OD2 ASP A 197 -11.140 -17. 989 -71. 506 1.00 26. 94 A 0

ATOM 2790 C ASP A 197 -10. 017 -13. ,340 -72. 308 1.00 28. 11 A c

ATOM 2791 O ASP A 197 -10. 823 -12. ,561 -71. 795 1.00 26. 28 A 0

ATOM 2793 N SER A 198 -8. 717 -13. 082 -72. 443 1.00 26. 36 A N

ATOM 2794 CA SER A 198 -8. 092 -11. ,839 -72. 036 1.00 28. 50 A c

ATOM 2796 CB SER A 198 -6. 642 -11. ,772 -72. 558 1.00 33. 13 A c

ATOM 2799 OG SER A 198 -5. 886 -12. ,947 -72. 253 1.00 33. 48 A 0

ATOM 2801 C SER A 198 -8. 896 -10. 655 -72. 582 1.00 25. 09 A c

ATOM 2802 O SER A 198 -9. 300 -10. 662 -73. 740 1.00 23. 64 A 0

ATOM 2804 N GLY A 199 -9. 150 -9. 663 -71. 738 1.00 21. 76 A N

ATOM 2805 CA GLY A 199 -9. 933 -8. ,492 -72. ,141 1.00 22. 98 A c

ATOM 2808 C GLY A 199 -11. 433 -8. ,620 -71. 935 1.00 21. 49 A c

ATOM 2809 O GLY A 199 -12. 158 -7. ,645 -72. 075 1.00 25. 37 A 0

ATOM 2811 N GLY A 200 -11. 915 -9. ,816 -71. 605 1.00 24. 68 A N

ATOM 2812 CA GLY A 200 -13. 349 -10. ,012 -71.375 1.00 22. 74 A c

ATOM 2815 C GLY A 200 -13. 785 -9. ,582 -69. 984 1.00 23. 75 A c

ATOM 2816 O GLY A 200 -12. 962 -9. ,212 -69. 147 1.00 25. 70 A 0

ATOM 2818 N PRO A 201 -15. ,095 -9. ,644 -69. 721 1.00 21. 81 A N

ATOM 2819 CA PRO A 201 -15. 674 -9. 158 -68. 482 1.00 21.05 A c

ATOM 2821 CB PRO A 201 -17. 066 -8. ,712 -68. ,914 1.00 18. 53 A c

ATOM 2824 CG PRO A 201 -17. 400 -9. ,582 -70. 078 1.00 20. ,74 A c

ATOM 2827 CD PRO A 201 -16. 124 -10. ,183 -70. 621 1.00 19. ,11 A c

ATOM 2830 C PRO A 201 -15. 789 -10. ,197 -67. 374 1.00 20. 79 A c

ATOM 2831 O PRO A 201 -16. 162 -11.333 -67. 632 1.00 22. 69 A 0

ATOM 2832 N LEU A 202 -15. 452 -9. ,779 -66. 157 1.00 21. ,21 A N

ATOM 2833 CA LEU A 202 -15. 835 -10. ,456 -64. ,929 1.00 19. ,29 A c

ATOM 2835 CB LEU A 202 -14. 663 -10. ,507 -63. 952 1.00 23. 65 A c

ATOM 2838 CG LEU A 202 -14. 803 -11. ,309 -62. 656 1.00 23. 29 A c

ATOM 2840 CDl LEU A 202 -14. ,815 -12. ,805 -62. 916 1.00 20. 55 A c

ATOM 2844 CD2 LEU A 202 -13. 689 -10. ,967 -61. ,723 1.00 20. ,52 A c

ATOM 2848 C LEU A 202 -16. 938 -9. ,581 -64. ,369 1.00 19. ,18 A c

ATOM 2849 O LEU A 202 -16. 699 -8. 414 -64. ,020 1.00 16. ,26 A 0

ATOM 2851 N VAL A 203 -18. 140 -10. ,146 -64. ,287 1.00 18. ,94 A N

ATOM 2852 CA VAL A 203 -19. 364 -9. 409 -63. ,945 1.00 14. ,05 A c

ATOM 2854 CB VAL A 203 -20. 354 -9. 513 -65. ,116 1.00 12. 86 A c cyno fD_Fab

ATOM 2856 CGl VAL A 203 -21.618 -8 . 716 -64. ,873 1.00 13. 22 A C

ATOM 2860 CG2 VAL A 203 -19. 685 -9. 024 -66. ,406 1.00 11. 48 A C

ATOM 2864 C VAL A 203 -19. 971 -9. 994 -62. ,663 1.00 15. 48 A c

ATOM 2865 O VAL A 203 -20. 260 -11.180 -62. ,610 1.00 12. ,73 A 0

ATOM 2867 N CYS A 204 -20. 155 -9. 158 -61. ,632 1.00 17. 62 A N

ATOM 2868 CA CYS A 204 -20. 630 -9. 613 -60. ,325 1.00 15. 36 A c

ATOM 2870 CB CYS A 204 -19. 597 -9. 326 -59. ,233 1.00 15. 35 A c

ATOM 2873 SG CYS A 204 -17. 892 -9. 788 -59. ,691 1.00 22. 33 A s

ATOM 2875 C CYS A 204 -21. 961 -8 . 954 -59. ,989 1.00 18. 76 A c

ATOM 2876 O CYS A 204 -22. 059 -7. 729 -59. ,918 1.00 18. 14 A 0

ATOM 2878 N GLY A 205 -22. 993 -9. 770 -59. ,800 1.00 18. 96 A N

ATOM 2879 CA GLY A 205 -24. 327 -9. 264 -59. ,507 1.00 17. 09 A c

ATOM 2882 C GLY A 205 -24. 905 -8. 314 -60. ,539 1.00 17. 30 A c

ATOM 2883 O GLY A 205 -25. 768 -7. 509 -60. ,214 1.00 26. 09 A 0

ATOM 2885 N GLY A 206 -24. 448 -8 . 429 -61. ,784 1.00 18. 79 A N

ATOM 2886 CA GLY A 206 -24. 883 -7. 569 -62. ,892 1.00 19. 04 A C

ATOM 2889 C GLY A 206 -23. 964 -6. 389 -63. 184 1.00 19. 01 A C

ATOM 2890 O GLY A 206 -24. 238 -5. 593 -64. 086 1. 00 20. 02 A 0

ATOM 2892 N VAL A 207 -22. 886 -6. 253 -62. ,417 1.00 17. 54 A N

ATOM 2893 CA VAL A 207 -22. 009 -5. 092 -62. ,531 1. 00 17. 29 A c

ATOM 2895 CB VAL A 207 -21. 971 -4. 268 -61. ,210 1.00 16. 77 A c

ATOM 2897 CGl VAL A 207 -21. 005 -3. 057 -61.324 1.00 10. 36 A c

ATOM 2901 CG2 VAL A 207 -23. 375 -3. 794 -60. ,847 1.00 11. 24 A c

ATOM 2905 C VAL A 207 -20. 607 -5. 553 -62. ,944 1. 00 17. 63 A c

ATOM 2906 O VAL A 207 -20. 048 -6. 484 -62. 362 1.00 19. 92 A 0

ATOM 2908 N LEU A 208 -20. 063 -4. 916 -63. ,973 1. 00 17. 54 A N

ATOM 2909 CA LEU A 208 -18. 699 -5. 196 -64. ,428 1.00 17. 57 A c

ATOM 2911 CB LEU A 208 -18. 407 -4. 431 -65. ,718 1. 00 16. 00 A c

ATOM 2914 CG LEU A 208 -16. 992 -4. 624 -66. ,263 1.00 15. 20 A c

ATOM 2916 CDl LEU A 208 -16. 957 -5. 933 -66. ,990 1. 00 14. 58 A c

ATOM 2920 CD2 LEU A 208 -16. 602 -3. 452 -67. ,161 1.00 16. 32 A c

ATOM 2924 C LEU A 208 -17. 705 -4. 785 -63. ,351 1.00 17. 52 A c

ATOM 2925 O LEU A 208 -17. 582 -3. 607 -63. ,038 1.00 22. 06 A 0

ATOM 2927 N GLU A 209 -17. 015 -5. 765 -62. ,772 1.00 22. 00 A N

ATOM 2928 CA GLU A 209 -16. 006 -5. 511 -61. ,746 1.00 19. 90 A c

ATOM 2930 CB GLU A 209 -16. 233 -6. 429 -60. ,548 1.00 20. 12 A c

ATOM 2933 CG GLU A 209 -17. 475 -6. 102 -59. ,742 1. 00 18. 24 A c

ATOM 2936 CD GLU A 209 -17. 350 -4. 838 -58. ,912 1.00 18. 76 A c

ATOM 2937 OEl GLU A 209 -16. 235 -4. 307 -58. ,791 1. 00 27. 02 A 0

ATOM 2938 OE2 GLU A 209 -18. 370 -4. 374 -58. ,363 1.00 23. 72 A 0

ATOM 2939 C GLU A 209 -14. 594 -5. 705 -62. ,261 1.00 21. 86 A c

ATOM 2940 O GLU A 209 -13. 669 -5. 108 -61. ,739 1.00 23. 57 A 0

ATOM 2942 N GLY A 210 -14. 426 -6. 544 -63. ,283 1.00 19. 36 A N

ATOM 2943 CA GLY A 210 -13. 102 -6. 904 -63. ,743 1.00 20. 95 A c

ATOM 2946 C GLY A 210 -12. 993 -7. 054 -65. ,240 1.00 17. 48 A c

ATOM 2947 O GLY A 210 -13. 979 -7. 222 -65. ,921 1. 00 15. 35 A 0

ATOM 2949 N VAL A 211 -11. 771 -6. 941 -65. ,742 1.00 23. 83 A N

ATOM 2950 CA VAL A 211 -11. 449 -7. 285 -67. ,112 1. 00 24. ,75 A C

ATOM 2952 CB VAL A 211 -10. 990 -6. 044 -67. ,911 1.00 26. 58 A C

ATOM 2954 CGl VAL A 211 -10. 502 -6. 440 -69, ,289 1.00 25. 54 A C

ATOM 2958 CG2 VAL A 211 -12. 117 -5. 048 -68. ,036 1.00 24. 15 A c

ATOM 2962 C VAL A 211 -10. 351 -8 . 343 -67. ,055 1.00 25. 92 A c

ATOM 2963 O VAL A 211 -9. 350 -8 . 141 -66. ,391 1. 00 25. 60 A 0

ATOM 2965 N VAL A 212 -10. 560 -9. 485 -67. ,715 1.00 28. 11 A N

ATOM 2966 CA VAL A 212 -9. 600 -10. 602 -67. ,695 1.00 32. 28 A c

ATOM 2968 CB VAL A 212 -10. 049 -11. 798 -68. ,632 1. 00 26. ,53 A c

ATOM 2970 CGl VAL A 212 -9. 027 -12. 933 -68. ,641 1.00 24. ,57 A c

ATOM 2974 CG2 VAL A 212 -11. 386 -12. 314 -68. ,214 1. 00 19. 84 A c

ATOM 2978 C VAL A 212 -8. 213 -10. 096 -68. ,097 1.00 35. 81 A c

ATOM 2979 O VAL A 212 -8 . 043 -9. 559 -69. ,193 1.00 35. 76 A 0

ATOM 2981 N THR A 213 -7. 241 -10. 260 -67. ,196 1. 00 40. 29 A N

ATOM 2982 CA THR A 213 -5. 888 -9. 714 -67. ,370 1. 00 42. 98 A c

ATOM 2984 CB THR A 213 -5. 178 -9. 521 -66. ,022 1.00 41. 71 A c

ATOM 2986 OG1 THR A 213 -5. 933 -8 . 625 -65. ,211 1. 00 43. ,58 A 0

ATOM 2988 CG2 THR A 213 -3. 771 -8 . 973 -66. ,208 1.00 40. ,06 A c

ATOM 2992 C THR A 213 -5. Oil -10. 637 -68. ,186 1.00 46. ,80 A c

ATOM 2993 O THR A 213 -4. 903 -11. 824 -67. ,876 1. 00 47. 51 A 0

ATOM 2995 N SER A 214 -4. 339 -10. 061 -69. ,183 1. 00 52. 77 A N cyno fD_Fab

ATOM 2996 CA SER A 214 -3. ,442 -10. 797 -70. ,078 1.00 55. 16 A C

ATOM 2998 CB SER A 214 -3. 207 -9. 985 -71.369 1.00 56. 98 A c

ATOM 3001 OG SER A 214 -3. 224 -10. 809 -72. ,531 1.00 59. 28 A 0

ATOM 3003 C SER A 214 -2. 105 -11. 169 -69. ,381 1.00 57. 56 A c

ATOM 3004 O SER A 214 -1. 700 -10. 547 -68. ,388 1.00 55. 71 A 0

ATOM 3006 N GLY A 215 -1. 441 -12. 197 -69. ,907 1.00 60. 48 A N

ATOM 3007 CA GLY A 215 -0. 192 -12. 720 -69. ,335 1.00 61. 29 A c

ATOM 3010 C GLY A 215 0. 092 -14. 141 -69. ,810 1.00 62. ,40 A c

ATOM 3011 O GLY A 215 -0. 740 -14. 758 -70. ,481 1.00 61. 13 A 0

ATOM 3013 N SER A 216 1. 261 -14. 670 -69. ,454 1.00 63. 59 A N

ATOM 3014 CA SER A 216 1. 695 -15. 997 -69. 932 1.00 62. 07 A c

ATOM 3016 CB SER A 216 3. 231 -16. 055 -69. 997 1.00 64. 66 A c

ATOM 3019 OG SER A 216 3. 681 -17. 314 -70. ,485 1.00 65. 95 A 0

ATOM 3021 C SER A 216 1. 160 -17. 165 -69. ,077 1.00 60. 62 A c

ATOM 3022 O SER A 216 1. 514 -18. 330 -69. ,305 1.00 57. 64 A 0

ATOM 3024 N ARG A 217 0. 296 -16. 839 -68. 115 1.00 58. 14 A N

ATOM 3025 CA ARG A 217 -0. 209 -17. 779 -67. 104 1.00 56. 02 A c

ATOM 3027 CB ARG A 217 -1. 166 -17. 018 -66. ,179 1.00 54. 28 A c

ATOM 3030 CG ARG A 217 -1. 568 -17. 733 -64. ,899 1.00 53. 34 A c

ATOM 3033 CD ARG A 217 -2. 680 -16. 945 -64. 204 1.00 50. 63 A c

ATOM 3036 NE ARG A 217 -3. 840 -16. 856 -65. 087 1.00 50. 26 A N

ATOM 3038 CZ ARG A 217 -4. 955 -17. 585 -64. 988 1.00 48. 61 A c

ATOM 3039 NHl ARG A 217 -5. 139 -18. 437 -63. ,994 1.00 47. 81 A N

ATOM 3042 NH2 ARG A 217 -5. 913 -17. 426 -65. ,878 1.00 44. 81 A N

ATOM 3045 C ARG A 217 -0. 927 -19. 012 -67. ,684 1.00 54. 16 A c

ATOM 3046 O ARG A 217 -1. 670 -18. 917 -68. 672 1.00 52. 76 A 0

ATOM 3048 N VAL A 218 -0. 692 -20. 164 -67. 054 1.00 53. 57 A N

ATOM 3049 CA VAL A 218 -1. 376 -21. 423 -67. 406 1.00 51. 91 A C

ATOM 3051 CB VAL A 218 -0. 643 -22. 668 -66. ,809 1.00 54. 01 A c

ATOM 3053 CGI VAL A 218 -0. 838 -22. 761 -65. ,262 1.00 50. 76 A c

ATOM 3057 CG2 VAL A 218 -1. 111 -23. 947 -67. ,501 1.00 54. 22 A c

ATOM 3061 C VAL A 218 -2. 798 -21.378 -66. ,862 1.00 50. 04 A c

ATOM 3062 0 VAL A 218 -3. 039 -20. 713 -65. ,848 1.00 52. 34 A 0

ATOM 3064 N CYS A 219 -3. 741 -22. 071 -67. ,504 1.00 43. 80 A N

ATOM 3065 CA CYS A 219 -5. 125 -22. 013 -67. ,027 1.00 41. 02 A c

ATOM 3067 CB CYS A 219 -6. 066 -21. 383 -68. 088 1.00 42. 98 A c

ATOM 3070 SG CYS A 219 -6. 944 -22. 500 -69. 232 1.00 41. 03 A s

ATOM 3072 C CYS A 219 -5. 612 -23. 363 -66. 513 1.00 32. 14 A c

ATOM 3073 0 CYS A 219 -5. 207 -24. 408 -66. ,999 1.00 33. ,42 A 0

ATOM 3075 N GLY A 220 -6. 460 -23. 322 -65. ,500 1.00 33. 38 A N

ATOM 3076 CA GLY A 220 -7. 041 -24. 523 -64. ,910 1.00 33. ,34 A c

ATOM 3079 C GLY A 220 -6. 297 -25. 025 -63. ,686 1.00 31. ,67 A c

ATOM 3080 0 GLY A 220 -6. 711 -26. 007 -63. ,063 1.00 27. ,93 A 0

ATOM 3082 N ASN A 221 -5. 219 -24. 333 -63. ,331 1.00 33. ,27 A N

ATOM 3083 CA ASN A 221 -4. 293 -24. 767 -62. ,279 1.00 32. 26 A c

ATOM 3085 CB ASN A 221 -2. 851 -24. 528 -62. ,764 1.00 34. 92 A c

ATOM 3088 CG ASN A 221 -1. 767 -25. 002 -61. ,772 1.00 36. ,56 A c

ATOM 3089 ODl ASN A 221 -2. 006 -25. 820 -60. ,876 1.00 34. 95 A 0

ATOM 3090 ND2 ASN A 221 -0. 549 -24. 476 -61. ,962 1.00 34. 90 A N

ATOM 3093 C ASN A 221 -4. 570 -23. 951 -61.037 1.00 25. ,99 A c

ATOM 3094 0 ASN A 221 -4. 488 -22. 724 -61. ,092 1.00 26. 89 A 0

ATOM 3096 N ARG A 222 -4. 912 -24. 632 -59. ,940 1.00 26. ,76 A N

ATOM 3097 CA ARG A 222 -5. 176 -24. 003 -58. ,634 1.00 29. ,73 A c

ATOM 3099 CB ARG A 222 -5. 530 -25. 075 -57. 594 1.00 37. ,03 A c

ATOM 3102 CG ARG A 222 -4. 373 -26. 038 -57. 285 1.00 41. ,65 A c

ATOM 3105 CD ARG A 222 -4. 659 -26. 957 -56. ,114 1.00 46. ,86 A c

ATOM 3108 NE ARG A 222 -3. 749 -28. 112 -56. ,097 1.00 50. ,54 A N

ATOM 3110 CZ ARG A 222 -3. 935 -29. 266 -56. ,756 1.00 53. ,52 A C

ATOM 3111 NHl ARG A 222 -5. Oil -29. 471 -57. ,518 1.00 51. ,75 A N

ATOM 3114 NH2 ARG A 222 -3. 028 -30. 237 -56. ,654 1.00 53. ,23 A N

ATOM 3117 C ARG A 222 -4. 042 -23. 159 -58. ,069 1.00 23. ,87 A C

ATOM 3118 0 ARG A 222 -4. 275 -22. 295 -57. ,235 1.00 27. .75 A 0

ATOM 3120 N LYS A 223 -2. 805 -23. 447 -58. ,472 1.00 26. ,24 A N

ATOM 3121 CA LYS A 223 -1. 658 -22. 711 -58. 004 1.00 20. ,88 A C

ATOM 3123 CB LYS A 223 -0. 355 -23. 505 -58. 232 1.00 24. 90 A C

ATOM 3126 CG LYS A 223 -0. 169 -24. 727 -57. ,290 1.00 21. 88 A c

ATOM 3129 CD LYS A 223 1. 213 -25. 412 -57. ,467 1.00 21. ,07 A c

ATOM 3132 CE LYS A 223 1. 403 -26. 534 -56. ,420 1.00 26. ,51 A c cyno fD_Fab

ATOM 3135 NZ LYS A 223 2. 790 -27. 103 -56. ,417 1. 00 24. 28 A N

ATOM 3139 C LYS A 223 -1. ,558 -21. 343 -58. ,667 1. 00 21. 19 A C

ATOM 3140 O LYS A 223 -0. 841 -20. 500 -58. ,188 1. 00 27. 59 A 0

ATOM 3142 N LYS A 224 -2. ,248 -21. 128 -59. ,785 1. 00 25. 34 A N

ATOM 3143 CA LYS A 224 -2. 233 -19. 832 -60. ,466 1. 00 20. 45 A C

ATOM 3145 CB LYS A 224 -1. 488 -19. 933 -61. ,816 1. 00 21. 13 A C

ATOM 3148 CG LYS A 224 0. 004 -20. 212 -61. ,637 1. 00 25. 76 A c

ATOM 3151 CD LYS A 224 0. 722 -19. 049 -60. ,928 1. 00 27. 94 A c

ATOM 3154 CE LYS A 224 2. 181 -19. 331 -60. ,628 1. 00 29. 94 A c

ATOM 3157 NZ LYS A 224 2. 301 -20. 420 -59. ,647 1. 00 32. 28 A N

ATOM 3161 C LYS A 224 -3. 636 -19. 319 -60. ,674 1. 00 19. 16 A c

ATOM 3162 0 LYS A 224 -4. 192 -19. 490 -61. ,757 1. 00 16. 40 A 0

ATOM 3164 N PRO A 225 -4. 228 -18. 698 -59. ,628 1. 00 19. 45 A N

ATOM 3165 CA PRO A 225 -5. 569 -18. 116 -59. ,753 1. 00 20. 40 A c

ATOM 3167 CB PRO A 225 -5. ,727 -17. 326 -58. ,437 1. 00 21. 17 A c

ATOM 3170 CG PRO A 225 -4. 878 -18. 086 -57. ,451 1. 00 22. 92 A c

ATOM 3173 CD PRO A 225 -3. 671 -18. 498 -58. ,273 1. 00 18. 87 A c

ATOM 3176 C PRO A 225 -5. 711 -17. 171 -60. ,955 1. 00 17. 36 A c

ATOM 3177 O PRO A 225 -4. 716 -16. 629 -61. ,435 1. 00 22. 41 A 0

ATOM 3178 N GLY A 226 -6. 943 -16. 980 -61. ,421 1. 00 22. 32 A N

ATOM 3179 CA GLY A 226 -7. 237 -16. 038 -62. ,500 1. 00 22. 47 A c

ATOM 3182 C GLY A 226 -7. 040 -14. 624 -62. ,019 1. 00 22. 96 A C

ATOM 3183 O GLY A 226 -7. 342 -14. 319 -60. 851 1. 00 18. 48 A 0

ATOM 3185 N ILE A 227 -6. 491 -13. 775 -62. 895 1. 00 24. 12 A N

ATOM 3186 CA ILE A 227 -6. 197 -12. 381 -62. 557 1. 00 25. 47 A C

ATOM 3188 CB ILE A 227 -4. 713 -11. 993 -62. ,793 1. 00 25. 51 A c

ATOM 3190 CGI ILE A 227 -3. 775 -12. 882 -61. 996 1. 00 23. 90 A c

ATOM 3193 CDl ILE A 227 -2. 309 -12. 671 -62. ,375 1. 00 26. 64 A c

ATOM 3197 CG2 ILE A 227 -4. 452 -10. 516 -62. ,395 1. 00 21. 56 A c

ATOM 3201 C ILE A 227 -7. 082 -11. 460 -63. ,376 1. 00 26. 31 A c

ATOM 3202 O ILE A 227 -7. 228 -11.621 -64. ,591 1. 00 23. 08 A 0

ATOM 3204 N TYR A 228 -7. 675 -10. 494 -62. ,686 1. 00 28. 36 A N

ATOM 3205 CA TYR A 228 -8. 632 -9. 564 -63. 290 1. 00 25. 01 A c

ATOM 3207 CB TYR A 228 -10. 077 -9. 960 -62. 903 1. 00 24. 06 A c

ATOM 3210 CG TYR A 228 -10. 363 -11. 419 -63. ,216 1. 00 25. 54 A c

ATOM 3211 CDl TYR A 228 -10. 913 -11. 800 -64. ,435 1. 00 25. 52 A c

ATOM 3213 CEl TYR A 228 -11. 132 -13. 143 -64. ,741 1. 00 23. 25 A c

ATOM 3215 cz TYR A 228 -10. 776 -14. 127 -63. ,824 1. 00 26. 58 A c

ATOM 3216 OH TYR A 228 -10. 985 -15. 480 -64. ,095 1. 00 25. 35 A 0

ATOM 3218 CE2 TYR A 228 -10. 215 -13. 765 -62. ,619 1. 00 26. 32 A c

ATOM 3220 CD2 TYR A 228 -10. Oil -12. 420 -62. ,322 1. 00 27. 08 A c

ATOM 3222 C TYR A 228 -8. 283 -8. 150 -62. ,850 1. 00 24. 13 A c

ATOM 3223 0 TYR A 228 -8. 038 -7. 901 -61. ,664 1. 00 27. 77 A 0

ATOM 3225 N THR A 229 -8. 249 -7. 226 -63. ,809 1. 00 26. 20 A N

ATOM 3226 CA THR A 229 -8. 058 -5. 799 -63. ,510 1. 00 25. 76 A c

ATOM 3228 CB THR A 229 -7. 546 -5. 033 -64. ,752 1. 00 25. 42 A c

ATOM 3230 OGl THR A 229 -6. 411 -5. 722 -65. ,301 1. 00 29. 63 A 0

ATOM 3232 CG2 THR A 229 -7. 131 -3. 655 -64. ,390 1. 00 25. 27 A c

ATOM 3236 C THR A 229 -9. 375 -5. 209 -63. ,015 1. 00 21. 74 A c

ATOM 3237 0 THR A 229 -10. 396 -5. 315 -63. ,679 1. 00 25. 52 A 0

ATOM 3239 N ARG A 230 -9. 352 -4. 616 -61. ,829 1. 00 22. 01 A N

ATOM 3240 CA ARG A 230 -10. 524 -3. 967 -61. ,270 1. 00 24. 73 A c

ATOM 3242 CB ARG A 230 -10. 323 -3. 694 -59. ,777 1. 00 24. 23 A c

ATOM 3245 CG ARG A 230 -10. 149 -4. 945 -58. ,964 1. 00 26. 03 A c

ATOM 3248 CD ARG A 230 -9. 920 -4. 647 -57. ,512 1. 00 22. 13 A c

ATOM 3251 NE ARG A 230 -11.021 -3. 862 -56. .997 1. 00 24. 28 A N

ATOM 3253 cz ARG A 230 -10. 974 -2. 579 -56. .669 1. 00 22. 93 A c

ATOM 3254 NHl ARG A 230 -9. 848 -1. 893 -56. ,740 1. 00 28. 99 A N

ATOM 3257 NH2 ARG A 230 -12. 073 -1. 986 -56. ,235 1. 00 23. 18 A N

ATOM 3260 C ARG A 230 -10. 802 -2. 643 -61. ,992 1. 00 24. 60 A C

ATOM 3261 0 ARG A 230 -9. 972 -1. 750 -61.971 1. 00 23. 54 A 0

ATOM 3263 N VAL A 231 -11. 971 -2. 511 -62. ,607 1. 00 28. 46 A N

ATOM 3264 CA VAL A 231 -12. 287 -1. 301 -63. ,386 1. 00 27. 54 A C

ATOM 3266 CB VAL A 231 -13. 401 -1. 549 -64. ,448 1. 00 25. ,49 A C

ATOM 3268 CGI VAL A 231 -12. 955 -2. 644 -65. .391 1. 00 23. ,60 A C

ATOM 3272 CG2 VAL A 231 -14. 750 -1. 877 -63. .797 1. 00 22. 57 A C

ATOM 3276 C VAL A 231 -12. 624 -0. 074 -62. .544 1. 00 27. 33 A c

ATOM 3277 0 VAL A 231 -12. 477 1. 041 -63. .034 1. 00 26. 83 A 0 cyno fD_Fab

ATOM 3279 N ALA A 232 -13. ,055 -0. 258 -61. ,295 1. 00 25. ,84 A N

ATOM 3280 CA ALA A 232 -13. ,308 0. 879 -60. ,410 1. 00 28. 11 A C

ATOM 3282 CB ALA A 232 -13. ,821 0. 402 -59. .054 1. 00 24. ,48 A C

ATOM 3286 C ALA A 232 -12. ,038 1. 724 -60. ,247 1. 00 29. ,08 A C

ATOM 3287 O ALA A 232 -12. ,084 2. 956 -60. ,264 1. 00 24. ,29 A 0

ATOM 3289 N SER A 233 -10. ,908 1. 036 -60. ,137 1. 00 31. 93 A N

ATOM 3290 CA SER A 233 -9. ,596 1. 654 -59, ,990 1. 00 33. ,67 A c

ATOM 3292 CB SER A 233 -8. ,522 0. 562 -59. ,924 1. 00 33. ,96 A c

ATOM 3295 OG ASER A 233 -8. ,562 -0. 129 -58. ,694 0. 70 34. 87 A 0

ATOM 3296 OG 1 3SER A 233 -8. ,579 -0. 133 -58. ,695 0. 30 34. 35 A 0

ATOM 3299 C SER A 233 -9. ,201 2. 606 -61.109 1. 00 35. 71 A c

ATOM 3300 O SER A 233 -8. ,324 3. 445 -60. ,919 1. 00 40. ,75 A 0

ATOM 3302 N TYR A 234 -9. ,809 2. 453 -62. ,278 1. 00 35. 00 A N

ATOM 3303 CA TYR A 234 -9. ,454 3. 263 -63. ,431 1. 00 33. 84 A C

ATOM 3305 CB TYR A 234 -8. ,972 2. 344 -64. ,565 1. 00 33. ,04 A C

ATOM 3308 CG TYR A 234 -7. ,739 1. 542 -64. ,194 1. 00 33. 40 A C

ATOM 3309 CDl TYR A 234 -6. ,460 2. 049 -64. ,431 1. 00 34. 91 A C

ATOM 3311 CEl TYR A 234 -5. ,317 1. 332 -64. ,079 1. 00 37. 04 A C

ATOM 3313 CZ TYR A 234 -5. ,441 0. 080 -63. ,487 1. 00 34. 27 A c

ATOM 3314 OH TYR A 234 -4. ,305 -0. 603 -63. ,138 1. 00 33. 36 A 0

ATOM 3316 CE2 TYR A 234 -6, ,699 -0. 450 -63. ,227 1. 00 32. ,49 A c

ATOM 3318 CD2 TYR A 234 -7. ,845 0. 287 -63. ,589 1. 00 33. 80 A c

ATOM 3320 C TYR A 234 -10. ,623 4. 140 -63. ,883 1. 00 32. ,94 A c

ATOM 3321 O TYR A 234 -10. ,692 4. 499 -65. ,048 1. 00 35. 23 A 0

ATOM 3323 N ALA A 235 -11.530 4. 485 -62. ,963 1. 00 32. 88 A N

ATOM 3324 CA ALA A 235 -12. 730 5. 278 -63. ,284 1. 00 38. 13 A c

ATOM 3326 CB ALA A 235 -13. ,613 5. 466 -62. ,038 1. 00 34. 67 A c

ATOM 3330 C ALA A 235 -12. 410 6. 644 -63. ,894 1. 00 40. 07 A c

ATOM 3331 O ALA A 235 -13. ,105 7. 099 -64. ,805 1. 00 40. 64 A 0

ATOM 3333 N ALA A 236 -11. ,370 7. 296 -63. ,383 1. 00 40. ,14 A N

ATOM 3334 CA ALA A 236 -10. ,970 8. 603 -63. ,884 1. 00 42. 82 A c

ATOM 3336 CB ALA A 236 -9. ,980 9. 272 -62. ,927 1. 00 45. ,37 A c

ATOM 3340 C ALA A 236 -10. ,369 8. 469 -65. ,281 1. 00 42. 28 A c

ATOM 3341 O ALA A 236 -10. 620 9. 298 -66. ,155 1. 00 44. 88 A 0

ATOM 3343 N TRP A 237 -9. 582 7. 425 -65. ,491 1. 00 42. 68 A N

ATOM 3344 CA TRP A 237 -8. 985 7. 177 -66. ,803 1. 00 42. 71 A c

ATOM 3346 CB TRP A 237 -7. ,964 6. 057 -66. ,735 1. 00 42. 74 A c

ATOM 3349 CG TRP A 237 -7. ,408 5. 731 -68. ,068 1. 00 42. 83 A c

ATOM 3350 CDl TRP A 237 -6. ,469 6. 434 -68. ,748 1. 00 42. ,44 A c

ATOM 3352 NEl TRP A 237 -6. ,197 5. 825 -69. ,946 1. 00 43. ,25 A N

ATOM 3354 CE2 TRP A 237 -6. ,986 4. 712 -70. ,069 1. 00 43. ,01 A c

ATOM 3355 CD2 TRP A 237 -7. ,765 4. 621 -68, ,899 1. 00 42. ,70 A c

ATOM 3356 CE3 TRP A 237 -8. ,656 3. 550 -68. ,762 1. 00 42. ,19 A c

ATOM 3358 CZ3 TRP A 237 -8. ,742 2. 624 -69. ,783 1. 00 41. ,96 A c

ATOM 3360 CH2 TRP A 237 -7. ,953 2. 738 -70. ,940 1. 00 42. 37 A c

ATOM 3362 CZ2 TRP A 237 -7. ,072 3. 774 -71. ,103 1. 00 43. ,38 A c

ATOM 3364 C TRP A 237 -10. ,035 6. 835 -67. .856 1. 00 44. ,38 A c

ATOM 3365 O TRP A 237 -9. ,970 7. 327 -68. .987 1. 00 45. ,85 A 0

ATOM 3367 N ILE A 238 -10. ,994 5. 988 -67. .487 1. 00 43. ,73 A N

ATOM 3368 CA ILE A 238 -12. ,069 5. 603 -68. .401 1. 00 42. ,04 A c

ATOM 3370 CB ILE A 238 -12. ,968 4. 482 -67. ,803 1. 00 38. ,51 A c

ATOM 3372 CGI ILE A 238 -12. ,188 3. 162 -67. ,715 1. 00 39. 24 A c

ATOM 3375 CDl ILE A 238 -12. ,970 2. 023 -67. ,102 1. 00 38. 64 A c

ATOM 3379 CG2 ILE A 238 -14. ,189 4. 253 -68. ,661 1. 00 38. 82 A c

ATOM 3383 C ILE A 238 -12. ,860 6. 865 -68. ,765 1. 00 41.74 A c

ATOM 3384 O ILE A 238 -13. ,103 7. 135 -69, ,938 1. ,00 41. ,34 A 0

ATOM 3386 N ASP A 239 -13. ,209 7. 652 -67, .750 1. 00 45. ,02 A N

ATOM 3387 CA ASP A 239 -13. ,864 8. ,958 -67, .944 1. 00 43. ,99 A c

ATOM 3389 CB ASP A 239 -14. ,010 9. 680 -66. .601 1. 00 43. ,49 A c

ATOM 3392 CG ASP A 239 -15. ,190 9. ,178 -65. .798 1. ,00 44. ,07 A c

ATOM 3393 ODl ASP A 239 -16. ,113 8. 595 -66. .407 1. 00 44. 92 A 0

ATOM 3394 OD2 ASP A 239 -15. ,197 9. ,372 -64. .560 1. 00 43. 08 A 0

ATOM 3395 C ASP A 239 -13. ,173 9. ,883 -68. ,954 1. 00 43. 22 A c

ATOM 3396 O ASP A 239 -13. ,822 10. ,378 -69. ,874 1. 00 44. ,74 A 0

ATOM 3398 N SER A 240 -11. .874 10. ,127 -68, ,792 1. ,00 44. ,13 A N

ATOM 3399 CA SER A 240 -11.165 11. ,007 -69, .721 1. ,00 45. ,86 A c

ATOM 3401 CB SER A 240 -9. ,682 11. ,156 -69, .355 1. ,00 45. ,16 A c

ATOM 3404 OG ASER A 240 -8. ,997 9. ,918 -69, ,400 0. ,60 46. ,17 A 0 cyrv fD_Fab

ATOM 3405 OG BSER A 240 -9.002 9. ,915 -69. 401 0.40 45. ,75 A 0

ATOM 3408 C SER A 240 -11.331 10. ,525 -71. 169 1.00 50. ,03 A C

ATOM 3409 O SER A 240 -11. 693 11.305 -72. 056 1.00 51.58 A 0

ATOM 3411 N VAL A 241 -11. 119 9. ,231 -71.392 1.00 50. ,96 A N

ATOM 3412 CA VAL A 241 -11. 151 8. ,666 -72. 742 1.00 46. ,94 A C

ATOM 3414 CB VAL A 241 -10. 546 7. ,230 -72. 751 1.00 44. ,94 A C

ATOM 3416 CGl VAL A 241 -10. 709 6. ,558 -74. 111 1.00 45. ,96 A C

ATOM 3420 CG2 VAL A 241 -9. 070 7. 283 -72. 368 1.00 38. ,44 A c

ATOM 3424 C VAL A 241 -12. 557 8. ,719 -73. 370 1.00 47. ,32 A c

ATOM 3425 O VAL A 241 -12. 686 8. 950 -74. 572 1.00 51. 82 A 0

ATOM 3427 N LEU A 242 -13. 603 8. ,560 -72. 561 1.00 47. ,39 A N

ATOM 3428 CA LEU A 242 -14. 973 8. ,407 -73. 088 1.00 46. ,77 A c

ATOM 3430 CB LEU A 242 -15. 777 7. ,431 -72. 209 1.00 45. ,42 A c

ATOM 3433 CG LEU A 242 -15. 793 5. ,967 -72. 676 1.00 45. ,47 A c

ATOM 3435 CDl LEU A 242 -14. 385 5. ,472 -72. 941 1.00 44. ,04 A c

ATOM 3439 CD2 LEU A 242 -16. 501 5. ,071 -71. 669 1.00 44. ,50 A c

ATOM 3443 C LEU A 242 -15. 760 9. ,716 -73. 280 1.00 50. ,61 A c

ATOM 3444 O LEU A 242 -16. 953 9. ,684 -73. 626 1.00 47. ,58 A 0

ATOM 3446 N ALA A 243 -15. 107 10. ,859 -73. 078 1.00 54. ,86 A N

ATOM 3447 CA ALA A 243 -15. 770 12. ,159 -73. 259 1.00 55. ,32 A C

ATOM 3449 CB ALA A 243 -16. 573 12. ,523 -72. 007 1.00 55. ,32 A C

ATOM 3453 C ALA A 243 -14. 763 13. ,260 -73. 595 1.00 60. ,01 A c

ATOM 3454 O ALA A 243 -15. 067 14. ,181 -74. 362 1.00 64. ,45 A 0

ATOM 3456 OXT ALA A 243 -13. 627 13. ,256 -73. 110 1.00 60. ,42 A 0

ATOM 3457 N ASP L 1 0. 320 -34. ,124 -43. 608 1.00 39. ,68 L N

ATOM 3458 CA ASP L 1 0. 857 -32. ,817 -44. 116 1.00 35. ,44 L c

ATOM 3460 CB ASP L 1 0. 855 -31. ,775 -43. 006 1.00 39. ,56 L c

ATOM 3463 CG ASP L 1 -0. 579 -31.443 -42. 504 1.00 43. ,75 L c

ATOM 3464 ODl ASP L 1 -1. 578 -32. ,039 -42. 992 1.00 35. ,08 L 0

ATOM 3465 OD2 ASP L 1 -0. 710 -30. ,574 -41.609 1.00 50. ,87 L 0

ATOM 3466 C ASP L 1 2. 250 -33. ,066 -44. 664 1.00 35. ,43 L c

ATOM 3467 0 ASP L 1 2. 807 -34. ,124 -44. 408 1.00 38. ,67 L 0

ATOM 3471 N ILE L 2 2. 799 -32. ,132 -45. 443 1.00 29. ,46 L N

ATOM 3472 CA ILE L 2 3. 967 -32. ,448 -46. 259 1.00 28. ,30 L c

ATOM 3474 CB ILE L 2 4. 118 -31.512 -47. 464 1.00 21. 86 L c

ATOM 3476 CGl ILE L 2 2. 883 -31. ,586 -48. 366 1.00 18. ,55 L c

ATOM 3479 CDl ILE L 2 2. 965 -30. ,723 -49. 583 1.00 20. ,84 L c

ATOM 3483 CG2 ILE L 2 5. 363 -31. ,876 -48. 240 1.00 20. .07 L c

ATOM 3487 C ILE L 2 5. 281 -32. ,464 -45. 477 1.00 28. ,84 L c

ATOM 3488 O ILE L 2 5. 632 -31. ,507 -44. 767 1.00 30. ,47 L 0

ATOM 3490 N GLN L 3 6. 021 -33. ,546 -45. 641 1.00 26. ,48 L N

ATOM 3491 CA GLN L 3 7. 277 -33. ,706 -44. 945 1.00 31. ,95 L c

ATOM 3493 CB GLN L 3 7. 383 -35. ,097 -44. 364 1.00 36. ,89 L c

ATOM 3496 CG GLN L 3 6. 342 -35. ,376 -43. 314 1.00 38. ,60 L c

ATOM 3499 CD GLN L 3 6. 154 -36. ,831 -43. 164 1.00 41. ,85 L c

ATOM 3500 OEl GLN L 3 5. 031 -37. .333 -43. 201 1.00 49. ,69 L 0

ATOM 3501 NE2 GLN L 3 7. 266 -37. .550 -43. ,040 1.00 45. .63 L N

ATOM 3504 C GLN L 3 8. 448 -33. ,451 -45. ,846 1.00 29. ,18 L c

ATOM 3505 O GLN L 3 8. 385 -33. .673 -47. 054 1.00 25. ,48 L 0

ATOM 3507 N VAL L 4 9. 529 -32. ,981 -45. ,234 1.00 31. ,71 L N

ATOM 3508 CA VAL L 4 10. 724 -32. ,607 -45. 966 1.00 26. ,51 L C

ATOM 3510 CB VAL L 4 10. 788 -31. ,079 -46. 128 1.00 22. ,86 L C

ATOM 3512 CGl VAL L 4 12. 180 -30. ,625 -46. 322 1.00 30. ,96 L c

ATOM 3516 CG2 VAL L 4 9. 941 -30. ,650 -47. 315 1.00 26. ,63 L c

ATOM 3520 C VAL L 4 11. 932 -33. .162 -45. ,224 1.00 28, .50 L c

ATOM 3521 O VAL L 4 12. 049 -33, .008 -43. ,995 1.00 26, ,20 L 0

ATOM 3523 N THR L 5 12. 808 -33. .851 -45. ,957 1.00 27. .71 L N

ATOM 3524 CA THR L 5 14. 044 -34, .375 -45. ,379 1.00 23. ,84 L c

ATOM 3526 CB THR L 5 14. 214 -35. .898 -45. 564 1.00 25. ,45 L c

ATOM 3528 OGl THR L 5 13. 056 -36. .585 -45. ,082 1.00 33. .94 L 0

ATOM 3530 CG2 THR L 5 15. 434 -36. ,385 -44. ,755 1.00 29. ,86 L c

ATOM 3534 C THR L 5 15. 222 -33. .676 -46. 022 1.00 16. ,29 L c

ATOM 3535 O THR L 5 15. 431 -33. .809 -47. ,224 1.00 20. .13 L 0

ATOM 3537 N GLN L 6 15. 999 -32, .965 -45. ,206 1.00 21.24 L N

ATOM 3538 CA GLN L 6 17. 197 -32, ,272 -45. ,656 1.00 24, .81 L C

ATOM 3540 CB GLN L 6 17. 246 -30, .883 -45. ,078 1.00 19, .28 L C

ATOM 3543 CG GLN L 6 18. 430 -30, .052 -45. ,607 1.00 24, .11 L c

ATOM 3546 CD GLN L 6 18. 256 -28, .571 -45. 332 1.00 25, ,58 L c cyno fD_Fab

ATOM 3547 OEl GLN L 6 17. 166 -28. 129 -44, ,974 1.00 27. 17 L 0

ATOM 3548 NE2 GLN L 6 19. 329 -27. 805 -45. ,483 1.00 26. 56 L N

ATOM 3551 C GLN L 6 18. 489 -32. 994 -45. ,294 1.00 27. 00 L C

ATOM 3552 O GLN L 6 18. 596 -33. ,551 -44. ,220 1.00 29. 70 L 0

ATOM 3554 N SER L 7 19. 456 -32. 968 -46, ,213 1.00 26. 45 L N

ATOM 3555 CA SER L 7 20. 789 -33. 547 -45. ,989 1.00 28. 93 L C

ATOM 3557 CB SER L 7 20. 851 -35. 018 -46, ,421 1.00 26. 48 L C

ATOM 3560 OG SER L 7 20. 201 -35. 195 -47. ,649 1.00 35. 79 L 0

ATOM 3562 C SER L 7 21.906 -32. 798 -46. ,712 1.00 23. 85 L c

ATOM 3563 O SER L 7 21. 692 -32. 232 -47. ,768 1.00 24. 96 L 0

ATOM 3565 N PRO L 8 23. 123 -32. 844 -46. ,163 1.00 22. 72 L N

ATOM 3566 CA PRO L 8 23. 534 -33. 498 -44. ,912 1.00 26. 52 L c

ATOM 3568 CB PRO L 8 25. 048 -33. 519 -45. ,034 1.00 24. 98 L c

ATOM 3571 CG PRO L 8 25. 360 -32. 290 -45. ,793 1.00 27. 22 L c

ATOM 3574 CD PRO L 8 24. 253 -32. 179 -46. ,822 1.00 25. 34 L c

ATOM 3577 C PRO L 8 23. 112 -32. 671 -43. ,696 1.00 22. 27 L c

ATOM 3578 O PRO L 8 22. 544 -31. 604 -43. ,884 1.00 27. 06 L 0

ATOM 3579 N SER L 9 23. 395 -33. 132 -42. ,477 1.00 26. 95 L N

ATOM 3580 CA SER L 9 23. 197 -32. 296 -41. 268 1.00 26. 60 L c

ATOM 3582 CB SER L 9 23. 343 -33. 116 -39. ,994 1.00 29. 70 L c

ATOM 3585 OG SER L 9 22. 538 -34. 265 -40. ,041 1.00 40. 54 L 0

ATOM 3587 C SER L 9 24. 209 -31. 168 -41.168 1.00 27. 29 L c

ATOM 3588 O SER L 9 23. 890 -30. 058 -40. ,752 1.00 22. 40 L 0

ATOM 3590 N SER L 10 25. 460 -31. 476 -41. ,482 1.00 26. 29 L N

ATOM 3591 CA SER L 10 26. 522 -30. 477 -41. ,410 1.00 27. 87 L c

ATOM 3593 CB SER L 10 27. 028 -30. 281 -39. ,963 1.00 31. 91 L c

ATOM 3596 OG SER L 10 27. 474 -31. 485 -39. 331 1.00 29. 68 L 0

ATOM 3598 C SER L 10 27. 647 -30. 887 -42. ,342 1.00 22. 10 L c

ATOM 3599 O SER L 10 27. 741 -32. 045 -42. ,712 1.00 29. 04 L 0

ATOM 3601 N LEU L 11 28. 461 -29. 923 -42. ,750 1.00 22. 92 L N

ATOM 3602 CA LEU L 11 29. 595 -30. 163 -43. ,647 1.00 23. 95 L c

ATOM 3604 CB LEU L 11 29. 116 -30. 261 -45. ,115 1.00 26. 33 L c

ATOM 3607 CG LEU L 11 28. 531 -29. 058 -45. ,886 1.00 25. 38 L c

ATOM 3609 CDl LEU L 11 29. 616 -28. 185 -46. ,525 1.00 19. 53 L c

ATOM 3613 CD2 LEU L 11 27. 603 -29. 541 -46. ,990 1.00 24. 48 L c

ATOM 3617 C LEU L 11 30. 690 -29. 088 -43. ,518 1.00 27. 32 L c

ATOM 3618 O LEU L 11 30. 414 -27. 979 -43. ,079 1.00 30. 55 L 0

ATOM 3620 N SER L 12 31. 928 -29. ,441 -43. ,896 1.00 31. 28 L N

ATOM 3621 CA SER L 12 33. 041 -28. 472 -44, ,028 1.00 27. 41 L c

ATOM 3623 CB SER L 12 34. 164 -28. 759 -43. ,026 1.00 26. 25 L c

ATOM 3626 OG SER L 12 33. 663 -28. ,844 -41. ,706 1.00 34. 73 L 0

ATOM 3628 C SER L 12 33. 631 -28. 539 -45, ,429 1.00 25. 16 L c

ATOM 3629 O SER L 12 33. 944 -29. 610 -45. ,913 1.00 21. 95 L 0

ATOM 3631 N ALA L 13 33. 813 -27. 387 -46, ,059 1.00 26. 96 L N

ATOM 3632 CA ALA L 13 34. 393 -27. 331 -47. ,388 1.00 27. 27 L c

ATOM 3634 CB ALA L 13 33. 303 -27. 199 -48, ,452 1.00 29. 19 L c

ATOM 3638 C ALA L 13 35. 318 -26. ,148 -47. ,402 1.00 30. ,02 L c

ATOM 3639 O ALA L 13 35. 190 -25. 258 -46, ,563 1.00 24. 82 L 0

ATOM 3641 N SER L 14 36. 261 -26. ,144 -48. .341 1.00 29. ,23 L N

ATOM 3642 CA SER L 14 37. 242 -25. ,057 -48. ,457 1.00 29. ,18 L c

ATOM 3644 CB SER L 14 38. 566 -25. ,569 -49. ,065 1.00 30. 28 L c

ATOM 3647 OG SER L 14 39. 044 -26. ,738 -48. ,414 1.00 31. ,00 L 0

ATOM 3649 C SER L 14 36. 695 -23. ,949 -49, ,335 1.00 25. ,20 L c

ATOM 3650 O SER L 14 35. 815 -24. 180 -50. ,151 1.00 32. ,36 L 0

ATOM 3652 N VAL L 15 37. 223 -22. ,749 -49, .163 1.00 24. ,39 L N

ATOM 3653 CA VAL L 15 36. 869 -21. ,612 -49, .984 1.00 27. ,55 L c

ATOM 3655 CB VAL L 15 37. 709 -20. ,371 -49, .566 1.00 27. ,46 L c

ATOM 3657 CGI VAL L 15 37. 610 -19. 251 -50, .602 1.00 29. 48 L c

ATOM 3661 CG2 VAL L 15 37. 291 -19. 877 -48. .185 1.00 26. 86 L c

ATOM 3665 C VAL L 15 37. 121 -21. ,986 -51. .451 1.00 32. 32 L c

ATOM 3666 0 VAL L 15 38. 206 -22. ,438 -51.794 1.00 34. 05 L 0

ATOM 3668 N GLY L 16 36. 098 -21. ,853 -52. ,288 1.00 33. ,09 L N

ATOM 3669 CA GLY L 16 36. 171 -22. ,208 -53. ,708 1.00 32. ,05 L c

ATOM 3672 C GLY L 16 35. 537 -23. .547 -54, ,026 1.00 36. ,11 L c

ATOM 3673 0 GLY L 16 35. 416 -23. ,925 -55, .191 1.00 41. ,60 L 0

ATOM 3675 N ASP L 17 35. 151 -24. ,279 -52, ,986 1.00 36. ,76 L N

ATOM 3676 CA ASP L 17 34. 546 -25. 580 -53, .143 1.00 31. ,73 L c

ATOM 3678 CB ASP L 17 34. 574 -26. ,411 -51, .822 1.00 31. ,16 L c cyno fD_Fab

ATOM 3681 CG ASP L 17 35. ,902 -27. ,181 -51. 611 1.00 32. 15 L C

ATOM 3682 ODl ASP L 17 36. ,829 -26. ,974 -52. 425 1.00 33. 00 L 0

ATOM 3683 OD2 ASP L 17 35. ,997 -28. ,019 -50. 654 1.00 24. ,25 L 0

ATOM 3684 C ASP L 17 33. ,120 -25. ,372 -53. 580 1.00 32. ,08 L C

ATOM 3685 O ASP L 17 32. ,532 -24. ,317 -53. 351 1.00 35. 87 L 0

ATOM 3687 N ARG L 18 32. ,567 -26. ,387 -54. 218 1.00 34. 16 L N

ATOM 3688 CA ARG L 18 31. ,141 -26. ,435 -54. 465 1.00 33. 01 L c

ATOM 3690 CB ARG L 18 30. ,846 -27. ,100 -55. 812 1.00 33. 19 L c

ATOM 3693 CG ARG L 18 29. ,359 -27. ,330 -56. 089 1.00 35. 75 L c

ATOM 3696 CD ARG L 18 29. ,156 -27. ,905 -57. 462 1.00 37. 32 L c

ATOM 3699 NE ARG L 18 29. ,553 -26. 954 -58. 488 1.00 36. 87 L N

ATOM 3701 CZ ARG L 18 29, ,498 -27. ,190 -59. 786 1.00 34. ,97 L c

ATOM 3702 NHl ARG L 18 29. ,049 -28. ,349 -60. 229 1.00 38. 66 L N

ATOM 3705 NH2 ARG L 18 29. ,877 -26. ,250 -60. 642 1.00 36. 37 L N

ATOM 3708 C ARG L 18 30. ,473 -27. 183 -53. 316 1.00 28. 49 L C

ATOM 3709 O ARG L 18 30. ,874 -28. 276 -52. 960 1.00 32. 92 L 0

ATOM 3711 N VAL L 19 29. ,447 -26. 573 -52. 738 1.00 34. 41 L N

ATOM 3712 CA VAL L 19 28. ,672 -27. ,175 -51. 661 1.00 26. 15 L C

ATOM 3714 CB VAL L 19 28. 517 -26. 188 -50. 477 1.00 29. 37 L C

ATOM 3716 CGI VAL L 19 27. ,402 -26.632 -49. 510 1.00 13. 13 L c

ATOM 3720 CG2 VAL L 19 29. ,825 -26. ,058 -49. 736 1.00 27. 77 L c

ATOM 3724 C VAL L 19 27. ,314 -27. ,540 -52. 221 1.00 28. 29 L c

ATOM 3725 O VAL L 19 26. ,685 -26. ,717 -52. 871 1.00 32. 27 L 0

ATOM 3727 N THR L 20 26. ,865 -28. ,777 -52. 004 1.00 30. 11 L N

ATOM 3728 CA THR L 20 25. ,578 -29. 215 -52. 546 1.00 28. 11 L c

ATOM 3730 CB THR L 20 25. 702 -30.235 -53. 721 1.00 28. 33 L c

ATOM 3732 OGl THR L 20 25. ,678 -31. 556 -53. 194 1.00 37. 86 L 0

ATOM 3734 CG2 THR L 20 26. ,998 -30. 033 -54. 549 1.00 28. 52 L c

ATOM 3738 C THR L 20 24. ,756 -29. 803 -51. 413 1.00 22. 56 L c

ATOM 3739 O THR L 20 25. ,264 -30. ,622 -50. 643 1.00 23. 99 L 0

ATOM 3741 N ILE L 21 23. ,500 -29. ,351 -51. 305 1.00 23. 02 L N

ATOM 3742 CA ILE L 21 22. ,597 -29. ,713 -50. 204 1.00 24. 76 L c

ATOM 3744 CB ILE L 21 22. 335 -28. ,500 -49. 276 1.00 26. 36 L c

ATOM 3746 CGI ILE L 21 23. ,636 -28. 022 -48. 661 1.00 27. 83 L c

ATOM 3749 CDl ILE L 21 23. ,499 -26. ,733 -47. 883 1.00 27. 59 L c

ATOM 3753 CG2 ILE L 21 21.284 -28. 846 -48. 184 1.00 24. 60 L c

ATOM 3757 C ILE L 21 21. ,252 -30. 203 -50. 772 1.00 25. 49 L c

ATOM 3758 O ILE L 21 20. ,670 -29. ,564 -51. 643 1.00 24. 12 L 0

ATOM 3760 N THR L 22 20. ,762 -31.322 -50. 258 1.00 28. 51 L N

ATOM 3761 CA THR L 22 19. ,543 -31. ,973 -50. 756 1.00 28. 34 L c

ATOM 3763 CB THR L 22 19. ,775 -33. ,484 -50. 860 1.00 27. 86 L c

ATOM 3765 OGl THR L 22 20. ,925 -33. ,702 -51. 685 1.00 28. 86 L 0

ATOM 3767 CG2 THR L 22 18. ,598 -34. ,169 -51. 487 1.00 31.64 L c

ATOM 3771 C THR L 22 18. ,312 -31. ,745 -49. 875 1.00 28. 39 L c

ATOM 3772 O THR L 22 18. ,417 -31. ,661 -48. 665 1.00 28. 85 L 0

ATOM 3774 N CYS L 23 17. ,152 -31. 651 -50. 515 1.00 24. 36 L N

ATOM 3775 CA CYS L 23 15. ,860 -31.713 -49. 844 1.00 30. ,90 L c

ATOM 3777 CB CYS L 23 15. ,220 -30. ,334 -49. 622 1.00 28. ,47 L c

ATOM 3780 SG CYS L 23 15. ,879 -29. ,641 -48. 113 1.00 46. 68 L s

ATOM 3782 C CYS L 23 14. ,948 -32. 589 -50. 648 1.00 24. 86 L c

ATOM 3783 O CYS L 23 14. 840 -32. 448 -51. 857 1.00 30. 27 L 0

ATOM 3785 N ILE L 24 14. 300 -33. ,497 -49. 944 1.00 21.35 L N

ATOM 3786 CA ILE L 24 13. 432 -34. ,470 -50. 550 1.00 21. 76 L C

ATOM 3788 CB ILE L 24 14. 022 -35. ,898 -50. 468 1.00 22. 43 L C

ATOM 3790 CGI ILE L 24 15. ,414 -35. ,929 -51. 152 1.00 26. 49 L C

ATOM 3793 CDl ILE L 24 16. ,068 -37. ,317 -51.209 1.00 25. ,20 L C

ATOM 3797 CG2 ILE L 24 13. ,119 -36. ,866 -51. 181 1.00 20. ,83 L c

ATOM 3801 C ILE L 24 12. ,102 -34. ,335 -49. 860 1.00 18. ,64 L c

ATOM 3802 0 ILE L 24 12. ,027 -34. 296 -48. 628 1.00 17. 98 L 0

ATOM 3804 N THR L 25 11. 050 -34. ,201 -50. 652 1.00 23. ,57 L N

ATOM 3805 CA THR L 25 9. 698 -34. 020 -50. 104 1.00 23. 75 L c

ATOM 3807 CB THR L 25 8. ,943 -32. 888 -50. 852 1.00 18. 41 L c

ATOM 3809 OGl THR L 25 8. ,984 -33. ,140 -52. 267 1.00 20.65 L 0

ATOM 3811 CG2 THR L 25 9. ,592 -31.554 -50. 576 1.00 14. 27 L c

ATOM 3815 C THR L 25 8. ,924 -35. ,327 -50. ,152 1.00 24. ,60 L c

ATOM 3816 0 THR L 25 9. ,258 -36. ,241 -50. ,907 1.00 20. ,79 L 0

ATOM 3818 N SER L 26 7. ,913 -35. ,429 -49. 292 1.00 27. ,54 L N

ATOM 3819 CA SER L 26 7. ,117 -36. ,638 -49. 187 1.00 26. ,71 L c cyno fD_Fab

ATOM 3821 CB SER L 26 6 270 -36. 584 -47 920 1.00 24 35 L C

ATOM 3824 OG SER L 26 5 555 -35. 374 -47 864 1.00 26 34 L 0

ATOM 3826 C SER L 26 6 201 -36. 887 -50 396 1.00 27 41 L c

ATOM 3827 O SER L 26 5 859 -38. 047 -50 695 1.00 29 52 L 0

ATOM 3829 N THR L 27 5 771 -35. 794 -51 029 1.00 25 00 L N

ATOM 3830 CA THR L 27 4 819 -35. 796 -52 150 1.00 22 02 L c

ATOM 3832 CB THR L 27 3 409 -35. 340 -51 688 1.00 20 90 L c

ATOM 3834 OGl THR L 27 2 438 -35. 709 -52 665 1.00 26 04 L 0

ATOM 3836 CG2 THR L 27 3 353 -33. 845 -51 474 1.00 14 67 L c

ATOM 3840 C THR L 27 5 299 -34. 800 -53 180 1.00 23 00 L c

ATOM 3841 O THR L 27 6 064 -33. 900 -52 833 1.00 22 69 L 0

ATOM 3843 N ASP L 28 4 850 -34. 955 -54 431 1.00 22 00 L N

ATOM 3844 CA ASP L 28 5 253 -34. 072 -55 552 1.00 18 45 L c

ATOM 3846 CB ASP L 28 4 624 -34. 602 -56 853 1.00 20 06 L c

ATOM 3849 CG ASP L 28 4 972 -33. 785 -58 088 1.00 24 86 L c

ATOM 3850 OOl ASP L 28 5 436 -32. 632 -57 975 1.00 27 72 L 0

ATOM 3851 OD2 ASP L 28 4 742 -34. 296 -59 213 1.00 26 40 L 0

ATOM 3852 C ASP L 28 4 800 -32. 638 -55 279 1.00 22 12 L c

ATOM 3853 0 ASP L 28 3 614 -32. 399 -55 072 1.00 27 10 L 0

ATOM 3855 N ILE L 29 5 745 -31. 695 -55 240 1.00 22 75 L N

ATOM 3856 CA ILE L 29 5 438 -30. 293 -54 968 1.00 18 57 L c

ATOM 3858 CB ILE L 29 6 226 -29. 738 -53 735 1.00 8 50 L c

ATOM 3860 CGl ILE L 29 7 748 -29. 896 -53 882 1.00 15 18 L c

ATOM 3863 CDl ILE L 29 8 588 -28. 706 -53 323 1.00 13 13 L c

ATOM 3867 CG2 ILE L 29 5 713 -30. 391 -52 379 1.00 9 90 L c

ATOM 3871 C ILE L 29 5 674 -29. 383 -56 192 1.00 23 83 L c

ATOM 3872 0 ILE L 29 5 738 -28. 151 -56 061 1.00 31 83 L 0

ATOM 3874 N ASP L 30 5 768 -29. 983 -57 373 1.00 25 88 L N

ATOM 3875 CA ASP L 30 6 128 -29. 279 -58 601 1.00 23 97 L c

ATOM 3877 CB ASP L 30 4 999 -28. 355 -59 054 1.00 25 05 L c

ATOM 3880 CG ASP L 30 3 685 -29. 096 -59 201 1.00 32 71 L c

ATOM 3881 ODl ASP L 30 3 671 -30. 091 -59 968 1.00 36 70 L 0

ATOM 3882 OD2 ASP L 30 2 685 -28. 706 -58 545 1.00 30 24 L 0

ATOM 3883 C ASP L 30 7 455 -28. 556 -58 395 1.00 22 32 L c

ATOM 3884 0 ASP L 30 8 430 -29. 195 -58 031 1.00 24 00 L 0

ATOM 3886 N ASP L 31 7 507 -27. 248 -58 600 1.00 20 65 L N

ATOM 3887 CA ASP L 31 8 760 -26. 525 -58 476 1.00 23 99 L c

ATOM 3889 CB ASP L 31 9 078 -25. 728 -59 763 1.00 28 76 L c

ATOM 3892 CG ASP L 31 8 067 -24. 620 -60 046 1.00 38 63 L c

ATOM 3893 ODl ASP L 31 7 014 -24. 592 -59 374 1.00 43 13 L 0

ATOM 3894 OD2 ASP L 31 8 309 -23. 776 -60 943 1.00 46 83 L 0

ATOM 3895 C ASP L 31 8 744 -25. 614 -57 265 1.00 22 71 L c

ATOM 3896 0 ASP L 31 9 570 -24. 726 -57 160 1.00 20 16 L 0

ATOM 3898 N ASP L 32 7 833 -25. 855 -56 318 1.00 28 27 L N

ATOM 3899 CA ASP L 32 7 597 -24. 916 -55 235 1.00 20 77 L c

ATOM 3901 CB ASP L 32 6 122 -24. 950 -54 827 1.00 29 58 L c

ATOM 3904 CG ASP L 32 5 237 -24. 379 -55 891 1.00 26 44 L c

ATOM 3905 ODl ASP L 32 5 508 -23. 213 -56 296 1.00 24 61 L 0

ATOM 3906 OD2 ASP L 32 4 305 -25. 096 -56 324 1.00 24 64 L 0

ATOM 3907 C ASP L 32 8 500 -25. 127 -54 033 1.00 24 20 L c

ATOM 3908 0 ASP L 32 8 044 -25. 367 -52 900 1.00 15 84 L 0

ATOM 3910 N MET L 33 9 795 -24. 983 -54 294 1.00 21 65 L N

ATOM 3911 CA MET L 33 10 836 -25. 134 -53 273 1.00 25 55 L c

ATOM 3913 CB MET L 33 11 856 -26. 184 -53 747 1.00 22 69 L c

ATOM 3916 CG MET L 33 12 972 -26. 481 -52 810 1.00 23 30 L c

ATOM 3919 SD MET L 33 12 461 -26. 911 -51 135 1.00 24 74 L s

ATOM 3920 CE MET L 33 11 715 -28. 515 -51 300 1.00 26 62 L c

ATOM 3924 C MET L 33 11 551 -23. 806 -53 020 1.00 27 50 L c

ATOM 3925 0 MET L 33 11 872 -23. 074 -53 953 1.00 28 56 L 0

ATOM 3927 N ASN L 34 11 810 -23. 517 -51 744 1.00 31 83 L N

ATOM 3928 CA ASN L 34 12 614 -22. 360 -51 350 1.00 26 61 L c

ATOM 3930 CB ASN L 34 11 755 -21. 394 -50 541 1.00 21 75 L c

ATOM 3933 CG ASN L 34 10 412 -21. 093 -51 214 1.00 19 36 L c

ATOM 3934 ODl ASN L 34 10 164 -19. 971 -51 623 1.00 21 78 L 0

ATOM 3935 ND2 ASN L 34 9 546 -22. 094 -51 314 1.00 18 75 L N

ATOM 3938 C ASN L 34 13 844 -22. 764 -50 525 1.00 24 66 L c

ATOM 3939 0 ASN L 34 13 883 -23. 829 -49 930 1.00 28 75 L 0

ATOM 3941 N TRP L 35 14 832 -21. 886 -50 496 1.00 24 16 L N ATOM 3942 CA TRP L 35 16 -49..784 1.00 22.,17 L C

ATOM 3944 CB TRP L 35 17. .201 -22. 410 -50. ,775 1.00 23. ,27 L C

ATOM 3947 CG TRP L 35 17. ,131 -23. 763 -51. 369 1.00 20. ,36 L c

ATOM 3948 CDl TRP L 35 16. ,749 -24. 076 -52. ,647 1.00 22. ,31 L c

ATOM 3950 NEl TRP L 35 16. ,825 -25. 420 -52. ,847 1.00 18. ,60 L N

ATOM 3952 CE2 TRP L 35 17. ,224 -26. 028 -51. ,688 1.00 20. ,03 L C

ATOM 3953 CD2 TRP L 35 17. ,438 -25. 014 -50. ,732 1.00 18. 92 L C

ATOM 3954 CE3 TRP L 35 17. ,892 -25. 375 -49. ,467 1.00 20. ,16 L c

ATOM 3956 CZ3 TRP L 35 18. ,110 -26. 744 -49. ,192 1.00 20. ,54 L c

ATOM 3958 CH2 TRP L 35 17. ,904 -27. 714 -50. ,161 1.00 20. ,08 L c

ATOM 3960 CZ2 TRP L 35 17. ,449 -27. 383 -51.412 1.00 23. ,98 L c

ATOM 3962 C TRP L 35 16. 406 -20. 840 -49. ,001 1.00 20. ,27 L c

ATOM 3963 O TRP L 35 16. 560 -19. 770 -49. ,586 1.00 19. ,60 L 0

ATOM 3965 N TYR L 36 16. 427 -20. 947 -47. ,670 1.00 25. ,41 L N

ATOM 3966 CA TYR L 36 16. ,842 -19. 835 -46. ,821 1.00 23. ,57 L c

ATOM 3968 CB TYR L 36 15. ,926 -19. 693 -45. ,597 1.00 25. ,19 L c

ATOM 3971 CG TYR L 36 14. ,473 -19. 357 -45. ,861 1.00 25. 99 L c

ATOM 3972 CDl TYR L 36 14. 009 -18. 045 -45. 726 1.00 21. 32 L c

ATOM 3974 CEl TYR L 36 12. ,697 -17. 732 -45. ,935 1.00 26. ,14 L c

ATOM 3976 CZ TYR L 36 11. ,801 -18. 719 -46. ,265 1.00 25. ,62 L c

ATOM 3977 OH TYR L 36 10. ,488 -18. 379 -46. ,453 1.00 28. ,27 L 0

ATOM 3979 CE2 TYR L 36 12. 220 -20. 039 -46. ,404 1.00 25. ,74 L c

ATOM 3981 CD2 TYR L 36 13. 553 -20. 349 -46. ,201 1.00 24. ,71 L c

ATOM 3983 C TYR L 36 18. ,294 -19. 979 -46. ,325 1.00 23. ,47 L c

ATOM 3984 O TYR L 36 18. 840 -21. 089 -46. 222 1.00 24. 41 L 0

ATOM 3986 N GLN L 37 18. 917 -18. 836 -46. ,014 1.00 19. 56 L N

ATOM 3987 CA GLN L 37 20. 226 -18. 818 -45. 365 1.00 23. 88 L c

ATOM 3989 CB GLN L 37 21. 245 -18. 062 -46. 210 1.00 24. 43 L c

ATOM 3992 CG GLN L 37 22. ,563 -17. 679 -45. ,483 1.00 22. ,44 L c

ATOM 3995 CD GLN L 37 23. ,402 -16. 742 -46. ,331 1.00 24. ,17 L c

ATOM 3996 OEl GLN L 37 23. 039 -15. 582 -46. ,513 1.00 33. ,10 L 0

ATOM 3997 NE2 GLN L 37 24. ,491 -17. 250 -46. ,903 1.00 23. ,99 L N

ATOM 4000 C GLN L 37 20. ,059 -18. 124 -44. 045 1.00 17. ,12 L c

ATOM 4001 O GLN L 37 19. 440 -17. 074 -43. 986 1.00 24. 86 L 0

ATOM 4003 N GLN L 38 20. 567 -18. 707 -42. 970 1.00 24. 77 L N

ATOM 4004 CA GLN L 38 20. 549 -17. 992 -41. ,686 1.00 25. ,58 L c

ATOM 4006 CB GLN L 38 19. 579 -18. 628 -40. ,715 1.00 22. 19 L c

ATOM 4009 CG GLN L 38 19. 356 -17. 810 -39. 436 1.00 21. 64 L c

ATOM 4012 CD GLN L 38 18. ,661 -18. 585 -38. ,367 1.00 26. 69 L c

ATOM 4013 OEl GLN L 38 18. ,684 -19. 815 -38. 366 1.00 31. 66 L 0

ATOM 4014 NE2 GLN L 38 18. 030 -17. 872 -37. ,429 1.00 17. ,41 L N

ATOM 4017 C GLN L 38 21. ,951 -17. 957 -41. ,100 1.00 29. ,75 L c

ATOM 4018 0 GLN L 38 22. ,482 -18. 986 -40. ,692 1.00 31. ,30 L 0

ATOM 4020 N LYS L 39 22. ,548 -16. 768 -41. ,076 1.00 30. ,91 L N

ATOM 4021 CA LYS L 39 23. 858 -16. 582 -40. ,465 1.00 31. 89 L c

ATOM 4023 CB LYS L 39 24. 555 -15. 350 -41. 033 1.00 35. ,23 L c

ATOM 4026 CG LYS L 39 24. 588 -15. 303 -42. ,567 1.00 35. ,45 L c

ATOM 4029 CD LYS L 39 25. 842 -14. 590 -43. ,047 1.00 38. ,63 L c

ATOM 4032 CE LYS L 39 25. ,647 -13. 726 -44. ,298 1.00 39. ,59 L c

ATOM 4035 NZ LYS L 39 26. ,303 -14. 324 -45. ,496 1.00 42. ,07 L N

ATOM 4039 C LYS L 39 23. ,702 -16. 474 -38. ,948 1.00 33. ,63 L c

ATOM 4040 0 LYS L 39 22. 599 -16. 193 -38. ,457 1.00 28. ,91 L 0

ATOM 4042 N PRO L 40 24. 790 -16. 759 -38. ,197 1.00 37. ,93 L N

ATOM 4043 CA PRO L 40 24. ,840 -16. 649 -36. ,728 1.00 37. ,74 L C

ATOM 4045 CB PRO L 40 26. 342 -16. 655 -36. ,433 1.00 40. ,69 L C

ATOM 4048 CG PRO L 40 26. 980 -17. 368 -37. ,594 1.00 40. ,63 L c

ATOM 4051 CD PRO L 40 26. 050 -17. 300 -38. ,757 1.00 38. ,43 L c

ATOM 4054 C PRO L 40 24. 195 -15. 371 -36. ,156 1.00 39. ,38 L c

ATOM 4055 0 PRO L 40 24. ,649 -14. 270 -36. .464 1.00 36. ,28 L 0

ATOM 4056 N GLY L 41 23. ,144 -15. 531 -35. ,350 1.00 35. ,09 L N

ATOM 4057 CA GLY L 41 22. 422 -14. 395 -34. .761 1.00 39. ,17 L c

ATOM 4060 C GLY L 41 21. 688 -13. 455 -35. .715 1.00 38. ,72 L c

ATOM 4061 0 GLY L 41 21. ,371 -12. 316 -35. ,352 1.00 33. ,46 L 0

ATOM 4063 N LYS L 42 21. ,424 -13. 922 -36. .935 1.00 39. ,83 L N

ATOM 4064 CA LYS L 42 20. ,719 -13. 127 -37. .937 1.00 37. ,06 L c

ATOM 4066 CB LYS L 42 21. ,546 -12. 976 -39. ,224 1.00 39. ,99 L c

ATOM 4069 CG LYS L 42 22. 928 -12. 342 -39. ,080 1.00 43. ,38 L c

ATOM 4072 CD LYS L 42 22. 904 -11. Oil -38. ,336 1.00 44. ,34 L c cyno fD_Fab

ATOM 4075 CE LYS L 42 24. ,307 -10. 398 -38. 236 1. 00 44. 50 L C

ATOM 4078 NZ LYS L 42 24. 438 -9. 439 -37. 084 1. 00 45. 59 L N

ATOM 4082 C LYS L 42 19. 368 -13. 760 -38. 276 1. 00 34. 04 L C

ATOM 4083 O LYS L 42 19. 130 -14. 937 -38. 003 1. 00 31. 67 L 0

ATOM 4085 N VAL L 43 18. ,496 -12. ,953 -38. ,874 1. 00 31. 52 L N

ATOM 4086 CA VAL L 43 17. 206 -13. ,419 -39. ,344 1. 00 29. 80 L C

ATOM 4088 CB VAL L 43 16.180 -12. 229 -39. ,474 1. 00 32. 57 L C

ATOM 4090 CGI VAL L 43 16. 455 -11.360 -40. 694 1. 00 35. 95 L C

ATOM 4094 CG2 VAL L 43 14. 760 -12. 743 -39. 526 1. 00 33. 03 L c

ATOM 4098 C VAL L 43 17. 431 -14. 190 -40. 655 1. 00 27. 97 L c

ATOM 4099 O VAL L 43 18. 371 -13. 872 -41. 420 1. 00 27. 65 L 0

ATOM 4101 N PRO L 44 16. 629 -15. 252 -40. 891 1. 00 25. 65 L N

ATOM 4102 CA PRO L 44 16. ,698 -15. 932 -42. 179 1. 00 26. 36 L c

ATOM 4104 CB PRO L 44 15. 603 -17. 001 -42. ,074 1. 00 24. 65 L c

ATOM 4107 CG PRO L 44 15. 539 -17. 286 -40. 614 1. 00 24. 48 L c

ATOM 4110 CD PRO L 44 15. 666 -15. 925 -39. 995 1. 00 24. 73 L c

ATOM 4113 C PRO L 44 16. 485 -15. 030 -43. 383 1. 00 25. 81 L c

ATOM 4114 0 PRO L 44 15. 659 -14. 101 -43. 354 1. 00 34. 05 L 0

ATOM 4115 N LYS L 45 17. 276 -15. 295 -44. 418 1. 00 28. 51 L N

ATOM 4116 CA LYS L 45 17. 189 -14. 594 -45. 688 1. 00 29. 34 L c

ATOM 4118 CB LYS L 45 18. 514 -13. 913 -46. 025 1. 00 30. 98 L c

ATOM 4121 CG LYS L 45 18. 502 -13. 084 -47. 293 1. 00 34. 25 L c

ATOM 4124 CD LYS L 45 19. 854 -12. 431 -47. 505 1. 00 35. 85 L c

ATOM 4127 CE LYS L 45 20. 155 -12. 118 -48. 979 1. 00 39. 81 L c

ATOM 4130 NZ LYS L 45 21. 671 -12. Oil -49. 211 1. 00 42. 04 L N

ATOM 4134 C LYS L 45 16. 823 -15. 625 -46. 741 1. 00 22. 45 L c

ATOM 4135 0 LYS L 45 17. 355 -16. 711 -46. 742 1. 00 23. 67 L 0

ATOM 4137 N LEU L 46 15. 878 -15. 290 -47. 612 1. 00 28. 51 L N

ATOM 4138 CA LEU L 46 15. 478 -16. 176 -48. 693 1. 00 29. 44 L c

ATOM 4140 CB LEU L 46 14. 035 -15. 907 -49. 125 1. 00 27. 74 L c

ATOM 4143 CG LEU L 46 13. 432 -16. 790 -50. 212 1. 00 26. 95 L c

ATOM 4145 CDl LEU L 46 13. 217 -18. 182 -49. 722 1. 00 29. 96 L c

ATOM 4149 CD2 LEU L 46 12. 130 -16. 242 -50. 678 1. 00 25. 49 L c

ATOM 4153 C LEU L 46 16. 431 -15. 917 -49. 837 1. 00 29. 15 L c

ATOM 4154 0 LEU L 46 16. 542 -14. 793 -50. 308 1. 00 29. 85 L 0

ATOM 4156 N LEU L 47 17. 130 -16. 962 -50. 261 1. 00 26. 91 L N

ATOM 4157 CA LEU L 47 18. 032 -16. 866 -51. 410 1. 00 29. 30 L c

ATOM 4159 CB LEU L 47 19. 312 -17. ,660 -51. 151 1. 00 26. 60 L c

ATOM 4162 CG LEU L 47 20. 169 -17. 302 -49. ,944 1. 00 27. ,06 L c

ATOM 4164 CDl LEU L 47 21. 481 -18. 057 -50. 023 1. 00 29. ,57 L c

ATOM 4168 CD2 LEU L 47 20. 418 -15. ,813 -49. 829 1. 00 28. ,71 L c

ATOM 4172 C LEU L 47 17. 407 -17. 348 -52. 723 1. 00 29. 56 L c

ATOM 4173 0 LEU L 47 17. 657 -16. 767 -53. 777 1. 00 24. 98 L 0

ATOM 4175 N ILE L 48 16. 632 -18. 431 -52. 653 1. 00 29. 93 L N

ATOM 4176 CA ILE L 48 16. 043 -19. 067 -53. 834 1. 00 29. 86 L c

ATOM 4178 CB ILE L 48 16. 714 -20. 421 -54. 175 1. 00 31.28 L c

ATOM 4180 CGI ILE L 48 18. ,252 -20. 310 -54. 230 1. 00 30. ,56 L c

ATOM 4183 CDl ILE L 48 18. 791 -19. ,744 -55. ,519 1. 00 29. ,17 L c

ATOM 4187 CG2 ILE L 48 16. 193 -20. 965 -55. ,505 1. 00 30. ,35 L c

ATOM 4191 C ILE L 48 14. 565 -19. ,334 -53. ,578 1. 00 30. ,99 L c

ATOM 4192 0 ILE L 48 14. 162 -19. ,761 -52. 484 1. 00 30. ,01 L 0

ATOM 4194 N SER L 49 13. 745 -19. ,073 -54. 581 1. 00 27. ,94 L N

ATOM 4195 CA SER L 49 12. 311 -19. ,306 -54. 455 1. 00 29. ,29 L c

ATOM 4197 CB SER L 49 11. 565 -17. ,982 -54. 462 1. 00 29. ,00 L c

ATOM 4200 OG SER L 49 11. ,904 -17. ,255 -55. ,629 1. 00 28. ,87 L 0

ATOM 4202 C SER L 49 11. ,855 -20. ,173 -55. ,604 1. 00 29. ,64 L c

ATOM 4203 0 SER L 49 12. ,597 -20. ,379 -56. ,547 1. 00 35. 91 L 0

ATOM 4205 N GLY L 50 10. ,615 -20. ,652 -55. ,520 1. 00 33. ,07 L N

ATOM 4206 CA GLY L 50 10. 043 -21. ,574 -56. ,478 1. 00 30. 92 L c

ATOM 4209 C GLY L 50 10. 491 -21. ,370 -57. ,906 1. 00 32. 01 L c

ATOM 4210 0 GLY L 50 10. 546 -20. ,234 -58. ,380 1. 00 35. 43 L 0

ATOM 4212 N GLY L 51 10. 801 -22. ,471 -58. 594 1. 00 26. ,66 L N

ATOM 4213 CA GLY L 51 11. 280 -22. ,407 -60. 003 1. 00 35. ,10 L c

ATOM 4216 C GLY L 51 12. ,785 -22. ,201 -60. ,067 1. ,00 37. ,69 L c

ATOM 4217 0 GLY L 51 13. ,396 -21. ,931 -61. ,143 1. 00 34. ,90 L 0

ATOM 4219 N ASN L 52 13. ,358 -22. ,324 -58. ,873 1. 00 40. ,07 L N

ATOM 4220 CA ASN L 52 14. 744 -22. ,029 -58. ,584 1. 00 38. ,26 L c

ATOM 4222 CB ASN L 52 15. 556 -23. ,266 -58. ,795 1. 00 40. ,16 L c cyno fD_Fab

ATOM 4225 CG ASN L 52 15. 135 -24. ,369 -57. ,782 1.00 42. 80 L C

ATOM 4226 ODl ASM L 52 15. 803 -25. 379 -57. ,641 1.00 53. 29 L 0

ATOM 4227 ND2 ASN L 52 14. 009 -24. 145 -57. ,069 1.00 42. 56 L N

ATOM 4230 C ASN L 52 15. 246 -20. 728 -59. ,177 1.00 36. 48 L C

ATOM 4231 O ASN L 52 16. 255 -20. 618 -59. ,886 1.00 38. 92 L 0

ATOM 4233 N THR L 53 14. 461 -19. 736 -58. ,770 1.00 32. 39 L N

ATOM 4234 CA THR L 53 14. 611 -18. 338 -59. ,066 1.00 32. 29 L c

ATOM 4236 CB THR L 53 13. 217 -17. ,664 -58. ,983 1.00 29. 69 L c

ATOM 4238 OGl THR L 53 12. 321 -18. ,346 -59. ,864 1.00 32. 35 L 0

ATOM 4240 CG2 THR L 53 13. 281 -16. 168 -59. ,320 1.00 26. 64 L c

ATOM 4244 C THR L 53 15. 489 -17. 761 -57. ,986 1.00 31. 58 L c

ATOM 4245 O THR L 53 15. 122 -17. 815 -56. 803 1.00 23. 39 L 0

ATOM 4247 N LEU L 54 16. 638 -17. 232 -58. 404 1.00 31. 18 L N

ATOM 4248 CA LEU L 54 17. 570 -16. 518 -57. ,532 1.00 31. 99 L c

ATOM 4250 CB LEU L 54 18. 958 -16. 428 -58. ,193 1.00 28. 80 L c

ATOM 4253 CG LEU L 54 20. 112 -15. 744 -57. ,437 1.00 33. 35 L c

ATOM 4255 CDl LEU L 54 20. 471 -16. 454 -56. ,127 1.00 30. 74 L c

ATOM 4259 CD 2 LEU L 54 21. 312 -15. 648 -58. 344 1.00 33. 92 L c

ATOM 4263 C LEU L 54 17. 065 -15. 125 -57. ,259 1.00 30. 83 L c

ATOM 4264 O LEU L 54 16. 852 -14. 348 -58. 201 1.00 28. 78 L 0

ATOM 4266 N ARG L 55 16. 902 -14. 799 -55. ,974 1.00 34. 36 L N

ATOM 4267 CA ARG L 55 16. 399 -13. 499 -55. ,566 1.00 35. 76 L c

ATOM 4269 CB ARG L 55 15. 995 -13. 487 -54. 072 1.00 42. 99 L c

ATOM 4272 CG ARG L 55 14. 716 -14. 345 -53. ,720 1.00 46. 72 L c

ATOM 4275 CD ARG L 55 13. 512 -14. 104 -54. ,684 1.00 48. 01 L c

ATOM 4278 NE ARG L 55 12. 227 -14. 692 -54. ,237 1.00 50. 48 L N

ATOM 4280 cz ARG L 55 11. 286 -14. 074 -53. ,510 1.00 49. 73 L c

ATOM 4281 NHl ARG L 55 11. 455 -12. 821 -53. 111 1.00 52. 37 L N

ATOM 4284 NH2 ARG L 55 10. 160 -14. 717 -53. ,175 1.00 47. 12 L N

ATOM 4287 C ARG L 55 17. 445 -12. 424 -55. ,875 1.00 38. 88 L C

ATOM 4288 0 ARG L 55 18. 645 -12. 642 -55. ,681 1.00 35. 64 L 0

ATOM 4290 N PRO L 56 16. 996 -11. 274 -56. ,415 1.00 42. 75 L N

ATOM 4291 CA PRO L 56 17. 910 -10. 164 -56. ,723 1.00 38. 04 L C

ATOM 4293 CB PRO L 56 16. 979 -9. 035 -57. ,185 1.00 40. 47 L C

ATOM 4296 CG PRO L 56 15. 594 -9. 551 -57. ,098 1.00 43. 33 L C

ATOM 4299 CD PRO L 56 15. 605 -10. 999 -56. ,818 1.00 40. 69 L C

ATOM 4302 C PRO L 56 18. 738 -9. 710 -55. ,521 1.00 35. 39 L c

ATOM 4303 O PRO L 56 18. 215 -9. 615 -54. ,414 1.00 31.42 L 0

ATOM 4304 N GLY L 57 20. 022 -9. 429 -55. ,752 1.00 36. 50 L N

ATOM 4305 CA GLY L 57 20. 952 -9. 083 -54. ,679 1.00 35. 10 L c

ATOM 4308 C GLY L 57 21. 757 -10. 262 -54. ,166 1.00 33. 15 L c

ATOM 4309 O GLY L 57 22. 854 -10. 089 -53. ,645 1.00 36. 74 L 0

ATOM 4311 N VAL L 58 21. 216 -11.469 -54. ,315 1.00 36. 35 L N

ATOM 4312 CA VAL L 58 21. 919 -12. 685 -53. ,926 1.00 34. 96 L c

ATOM 4314 CB VAL L 58 20. 922 -13. 823 -53. ,634 1.00 31. 40 L c

ATOM 4316 CGI VAL L 58 21. 643 -15. 051 -53. ,159 1.00 24. 70 L c

ATOM 4320 CG2 VAL L 58 19. 910 -13. 369 -52. ,588 1.00 30. 20 L c

ATOM 4324 C VAL L 58 22. 911 -13. 064 -55. ,046 1.00 37. 32 L c

ATOM 4325 O VAL L 58 22. 561 -12. 994 -56. ,227 1.00 37. 20 L 0

ATOM 4327 N PRO L 59 24. 165 -13. ,408 -54. ,685 1.00 36. 98 L N

ATOM 4328 CA PRO L 59 25. 184 -13. ,728 -55. ,696 1.00 37. 70 L c

ATOM 4330 CB PRO L 59 26. 432 -13. 999 -54. ,855 1.00 40. 50 L c

ATOM 4333 CG PRO L 59 26. 182 -13. 278 -53. ,568 1.00 40. 80 L c

ATOM 4336 CD PRO L 59 24. 729 -13. 428 -53. ,326 1.00 37. 44 L c

ATOM 4339 C PRO L 59 24. 872 -14. 928 -56. ,589 1.00 40. 91 L c

ATOM 4340 O PRO L 59 24. 264 -15. 903 -56. ,141 1.00 45. 71 L 0

ATOM 4341 N SER L 60 25. 305 -14. 856 -57. ,846 1.00 39. 77 L N

ATOM 4342 CA SER L 60 25. 079 -15. 922 -58. ,812 1.00 37. 60 L c

ATOM 4344 CB SER L 60 25. 563 -15. 489 -60. ,202 1.00 42. 77 L c

ATOM 4347 OG SER L 60 26. 952 -15. ,191 -60. ,207 1.00 44. 83 L 0

ATOM 4349 C SER L 60 25. 738 -17. ,257 -58. ,428 1.00 38. 54 L c

ATOM 4350 O SER L 60 25. 451 -18. 297 -59. ,037 1.00 38. 30 L 0

ATOM 4352 N ARG L 61 26. 613 -17. 259 -57. ,426 1.00 34. 92 L N

ATOM 4353 CA ARG L 61 27. 218 -18. 532 -57. ,003 1.00 31. 55 L c

ATOM 4355 CB ARG L 61 28. 444 -18. 317 -56. ,098 1.00 31.06 L c

ATOM 4358 CG ARG L 61 28. 142 -17. 732 -54. ,727 1.00 34. 63 L c

ATOM 4361 CD ARG L 61 29. 338 -17. 887 -53. ,785 1.00 34. 52 L c

ATOM 4364 NE ARG L 61 29. 144 -17. 107 -52. ,568 1.00 35. 07 L N cyno fD_Fab

ATOM 4366 CZ ARG L 61 29. 317 -15. 793 -52. ,479 1.00 35. 28 L C

ATOM 4367 NHl ARG L 61 29. 681 -15. 080 -53. 535 1.00 40. 23 L N

ATOM 4370 NH2 ARG L 61 29. ,117 -15. 176 -51.322 1.00 35. 77 L N

ATOM 4373 C ARG L 61 26. .175 -19. ,473 -56. ,375 1.00 28. ,28 L C

ATOM 4374 O ARG L 61 26. ,363 -20. 698 -56. ,373 1.00 28. ,68 L 0

ATOM 4376 N PHE L 62 25. 075 -18. 910 -55. ,865 1.00 32. ,78 L N

ATOM 4377 CA PHE L 62 23. ,943 -19. 704 -55. ,370 1.00 29. ,72 L C

ATOM 4379 CB PHE L 62 23. 162 -18. 929 -54. 317 1.00 30. 01 L C

ATOM 4382 CG PHE L 62 23. ,925 -18. 655 -53. 061 1.00 28. 54 L C

ATOM 4383 CDl PHE L 62 23. ,847 -19. 530 -51. 980 1.00 29. 80 L c

ATOM 4385 CEl PHE L 62 24. 530 -19. 274 -50. 818 1.00 29. 58 L c

ATOM 4387 CZ PHE L 62 25. 289 -18. 122 -50. 707 1.00 30. 15 L c

ATOM 4389 CE2 PHE L 62 25. ,369 -17. 231 -51. ,771 1.00 28. ,84 L c

ATOM 4391 CD2 PHE L 62 24. ,690 -17. 503 -52. 938 1.00 32. 91 L c

ATOM 4393 C PHE L 62 22. ,965 -20. 079 -56. 471 1.00 29. 31 L c

ATOM 4394 O PHE L 62 22. 393 -19. 196 -57. 127 1.00 29. 29 L 0

ATOM 4396 N SER L 63 22. 747 -21. 383 -56. 652 1.00 27. 16 L N

ATOM 4397 CA SER L 63 21.741 -21. 887 -57. 605 1.00 31. 28 L c

ATOM 4399 CB SER L 63 22. 396 -22. 392 -58. 893 1.00 27. 83 L c

ATOM 4402 OG SER L 63 23. 470 -23. 230 -58. 557 1.00 34. 49 L 0

ATOM 4404 C SER L 63 20. 889 -22. 988 -57. 002 1.00 31. 82 L c

ATOM 4405 O SER L 63 21. ,319 -23. 705 -56. 097 1.00 37. 45 L 0

ATOM 4407 N GLY L 64 19. ,654 -23. 086 -57. 490 1.00 30. 47 L N

ATOM 4408 CA GLY L 64 18. 760 -24. 150 -57. 104 1.00 28. 02 L c

ATOM 4411 C GLY L 64 18. 483 -25. 016 -58. 313 1.00 27. 03 L c

ATOM 4412 0 GLY L 64 18. 468 -24. 526 -59. 434 1.00 34. 99 L 0

ATOM 4414 N SER L 65 18. 257 -26. 305 -58. 088 1.00 30. 05 L N

ATOM 4415 CA SER L 65 17. 753 -27. 189 -59. 134 1.00 29. 26 L C

ATOM 4417 CB SER L 65 18. 903 -27. 902 -59. 858 1.00 34. 20 L C

ATOM 4420 OG SER L 65 19. 588 -28. 813 -59. 018 1.00 39. 69 L 0

ATOM 4422 C SER L 65 16. 748 -28. 184 -58. 592 1.00 28. 73 L c

ATOM 4423 O SER L 65 16. 629 -28. 385 -57. 383 1.00 32. 61 L 0

ATOM 4425 N GLY L 66 15. 997 -28. 782 -59. 508 1.00 30. 22 L N

ATOM 4426 CA GLY L 66 15. 077 -29. 845 -59. 172 1.00 27. 50 L c

ATOM 4429 C GLY L 66 13. 626 -29. 460 -59. 307 1.00 26. 84 L c

ATOM 4430 O GLY L 66 13. 264 -28. 283 -59. 321 1.00 31. 78 L 0

ATOM 4432 N SER L 67 12. 793 -30. 486 -59. 376 1.00 31.57 L N

ATOM 4433 CA SER L 67 11. 363 -30. 356 -59. 557 1.00 33. 48 L c

ATOM 4435 CB SER L 67 11. ,050 -30. 073 -61. ,031 1.00 40. 62 L c

ATOM 4438 OG SER L 67 9. 708 -29. 636 -61. ,152 1.00 50. 74 L 0

ATOM 4440 C SER L 67 10. 722 -31. 668 -59. 133 1.00 33. 67 L c

ATOM 4441 O SER L 67 11.302 -32. 728 -59. 355 1.00 43. 40 L 0

ATOM 4443 N GLY L 68 9. 547 -31. 615 -58. 508 1.00 29. 66 L N

ATOM 4444 CA GLY L 68 8. 871 -32. 831 -58. 094 1.00 27. 58 L c

ATOM 4447 C GLY L 68 9. 060 -33. 104 -56. 624 1.00 25. 21 L c

ATOM 4448 O GLY L 68 8. 441 -32. 430 -55. 807 1.00 24. 35 L 0

ATOM 4450 N THR L 69 9. ,911 -34. 087 -56. ,281 1.00 29. 76 L N

ATOM 4451 CA THR L 69 10. 236 -34. 396 -54. ,873 1.00 23. 15 L c

ATOM 4453 CB THR L 69 9. 956 -35. 884 -54. ,475 1.00 22. 87 L c

ATOM 4455 OGl THR L 69 10. 811 -36. 762 -55. 218 1.00 28. 34 L 0

ATOM 4457 CG2 THR L 69 8. 521 -36. 271 -54. 697 1.00 16. 94 L c

ATOM 4461 C THR L 69 11. 680 -34. 089 -54. 462 1.00 22. 23 L c

ATOM 4462 O THR L 69 11. 935 -33. 888 -53. 285 1.00 21. 49 L 0

ATOM 4464 N ASP L 70 12. 610 -34. 061 -55. 416 1.00 25. 31 L N

ATOM 4465 CA ASP L 70 14. ,055 -34. 065 -55. ,134 1.00 23. ,44 L c

ATOM 4467 CB ASP L 70 14. ,757 -35. 095 -56. ,017 1.00 29. ,31 L c

ATOM 4470 CG ASP L 70 14. 544 -36. ,534 -55. ,591 1.00 27. 13 L c

ATOM 4471 ODl ASP L 70 13. 617 -36. 909 -54. ,823 1.00 28. 62 L 0

ATOM 4472 OD2 ASP L 70 15. 334 -37. 327 -56. ,096 1.00 31. 58 L 0

ATOM 4473 C ASP L 70 14. 707 -32. 725 -55. ,458 1.00 24. 18 L c

ATOM 4474 O ASP L 70 14. 801 -32. 364 -56. 622 1.00 24. 97 L 0

ATOM 4476 N PHE L 71 15. 181 -31. 995 -54. ,448 1.00 23. 17 L N

ATOM 4477 CA PHE L 71 15. 741 -30. 653 -54. 678 1.00 24. 80 L c

ATOM 4479 CB PHE L 71 14. 805 -29. ,594 -54. ,086 1.00 23. ,84 L c

ATOM 4482 CG PHE L 71 13. 422 -29. ,639 -54. ,656 1.00 22. ,41 L c

ATOM 4483 CDl PHE L 71 13. 084 -28. ,848 -55. ,749 1.00 27. 90 L c

ATOM 4485 CEl PHE L 71 11. 825 -28. 910 -56. ,294 1.00 27. 80 L c

ATOM 4487 CZ PHE L 71 10. 884 -29. 768 -55. ,747 1.00 28. 31 L c cyno fD_Fab

ATOM 4489 CE2 PHE L 71 11. 208 -30. 573 -54. ,697 1.00 22. ,97 L C

ATOM 4491 CD2 PHE L 71 12. 476 -30. 501 -54. ,145 1.00 24. ,87 L C

ATOM 4493 C PHE L 71 17. 176 -30. 460 -54. 149 1.00 17. 22 L C

ATOM 4494 O PHE L 71 17. 575 -31. 069 -53. 171 1.00 22. 61 L 0

ATOM 4496 N THR L 72 17. 923 -29. 592 -54. 816 1.00 22. ,55 L N

ATOM 4497 CA THR L 72 19.340 -29. 347 -54. 526 1.00 27. 48 L C

ATOM 4499 CB THR L 72 20. 236 -29. 980 - 55 . 638 1.00 28. 08 L C

ATOM 4501 OGl THR L 72 19. 871 -31. .354 -55. 789 1.00 33 . ,64 L 0

ATOM 4503 CG2 THR L 72 21. 731 -29. ,908 - 55 . 313 1.00 27. ,74 L c

ATOM 4507 C THR L 72 19. 581 -27. ,837 -54. 421 1.00 26. ,21 L c

ATOM 4508 O THR L 72 19. 054 -27. ,066 - 55 . 225 1.00 27. ,18 L 0

ATOM 4510 N LEU L 73 20.346 -27. ,431 -53. ,410 1.00 27. ,45 L N

ATOM 4511 CA LEU L 73 21. 026 -26. ,126 -53. 384 1.00 28. 71 L c

ATOM 4513 CB LEU L 73 20. 796 -25. 399 -52. 060 1.00 29. 97 L c

ATOM 4516 CG LEU L 73 21. 533 -24. ,079 -51. 824 1.00 29. 03 L c

ATOM 4518 CDl LEU L 73 20. 930 -22. ,892 -52. 621 1.00 26. 07 L c

ATOM 4522 CD2 LEU L 73 21. 495 -23. 805 -50. 344 1.00 28. 64 L c

ATOM 4526 C LEU L 73 22. 528 -26. 331 -53. 620 1.00 30. 11 L c

ATOM 4527 O LEU L 73 23. 169 -27. ,168 -52. 987 1.00 35. ,54 L 0

ATOM 4529 N THR L 74 23. 072 -25. ,557 -54. 547 1.00 29. 24 L N

ATOM 4530 CA THR L 74 24. 477 -25. ,605 -54. 906 1.00 30. 11 L c

ATOM 4532 CB THR L 74 24. 655 -25. ,967 -56. 398 1.00 30. ,17 L c

ATOM 4534 OGl THR L 74 24. 022 -27. 220 -56. 674 1.00 28. 59 L 0

ATOM 4536 CG2 THR L 74 26. 155 -26. ,064 -56. 783 1.00 28. 72 L c

ATOM 4540 C THR L 74 25. 065 -24. 223 -54. 627 1.00 31.00 L c

ATOM 4541 O THR L 74 24. 691 -23. ,265 -55. 284 1.00 32. 34 L 0

ATOM 4543 N ILE L 75 25. 944 -24. ,104 -53. 629 1.00 30. 28 L N

ATOM 4544 CA ILE L 75 26. 796 -22. 915 -53. 505 1.00 31. 22 L c

ATOM 4546 CB ILE L 75 27. 199 -22. ,546 -52. 066 1.00 25. 59 L c

ATOM 4548 CGl ILE L 75 26. 014 -22. ,578 -51. 106 1.00 27. ,18 L c

ATOM 4551 CDl ILE L 75 26. 445 -22. ,429 -49. 658 1.00 23. 10 L c

ATOM 4555 CG2 ILE L 75 27. 871 -21. ,167 -52. 071 1.00 21. 88 L c

ATOM 4559 C ILE L 75 28. 073 -23. ,235 -54. 252 1.00 25. 24 L c

ATOM 4560 O ILE L 75 28. 889 -24. ,047 -53. 792 1.00 30. 52 L 0

ATOM 4562 N SER L 76 28. 267 -22. ,599 - 55 . 392 1.00 34. 57 L N

ATOM 4563 CA SER L 76 29. 244 -23. ,102 -56. 354 1.00 36. 92 L C

ATOM 4565 CB SER L 76 28. 832 -22. ,716 -57. 767 1.00 43. 47 L C

ATOM 4568 OG SER L 76 29. 581 -23. ,457 -58. 709 1.00 50. 61 L 0

ATOM 4570 C SER L 76 30. 689 -22. ,686 -56. ,130 1.00 41. ,87 L c

ATOM 4571 O SER L 76 31.612 -23. ,344 -56. 636 1.00 54. 07 L 0

ATOM 4573 N SER L 77 30. 928 -21.601 -55 . ,412 1.00 40. ,23 L N

ATOM 4574 CA SER L 77 32. 314 -21. 197 -55. 217 1.00 36. ,15 L c

ATOM 4576 CB SER L 77 32. 712 -20. 230 -56. 324 1.00 42. 00 L c

ATOM 4579 OG SER L 77 34. 107 -20. 077 -56. 375 1.00 43. ,96 L 0

ATOM 4581 C SER L 77 32. 466 -20. ,591 -53. ,841 1.00 33. 65 L c

ATOM 4582 O SER L 77 32. 514 -19. 365 -53. 694 1.00 39. ,60 L 0

ATOM 4584 N LEU L 78 32. 552 -21. 478 -52. 841 1.00 24. 50 L N

ATOM 4585 CA LEU L 78 32. 206 -21. ,146 -51.458 1.00 25. 00 L c

ATOM 4587 CB LEU L 78 32. 273 -22. .391 -50. ,573 1.00 22. 30 L c

ATOM 4590 CG LEU L 78 31. 810 -22. ,220 -49. ,121 1.00 22. ,91 L c

ATOM 4592 CDl LEU L 78 30. 308 -21. .885 -49. ,060 1.00 22. ,42 L c

ATOM 4596 CD2 LEU L 78 32. 129 -23. ,457 -48. 291 1.00 22. 89 L c

ATOM 4600 C LEU L 78 33 . 116 -20. ,063 -50. ,913 1.00 28. ,19 L c

ATOM 4601 O LEU L 78 34. 333 -20. .131 -51. ,064 1.00 35. 35 L 0

ATOM 4603 N GLN L 79 32. 515 -19. ,037 -50. ,325 1.00 27. ,53 L N

ATOM 4604 CA GLN L 79 33 . 243 -17. ,905 -49. ,800 1.00 26. ,14 L c

ATOM 4606 CB GLN L 79 32. 663 -16. ,615 -50. ,384 1.00 28. ,06 L c

ATOM 4609 CG GLN L 79 32. 879 -16. ,471 -51. 876 1.00 28. ,35 L c

ATOM 4612 CD GLN L 79 34. 337 -16. ,528 -52. ,220 1.00 27. 68 L c

ATOM 4613 OEl GLN L 79 35. 126 -15. ,745 -51. ,700 1.00 26. ,91 L 0

ATOM 4614 NE2 GLN L 79 34. 719 -17. .482 -53. ,068 1.00 24. 25 L N

ATOM 4617 C GLN L 79 33 . 162 -17. ,891 -48. ,277 1.00 29. ,05 L c

ATOM 4618 O GLN L 79 32. 262 -18. ,496 -47. ,696 1.00 30. ,68 L 0

ATOM 4620 N PRO L 80 34. 122 -17. ,229 -47. ,617 1.00 30. , 26 L N

ATOM 4621 CA PRO L 80 34. 111 -17. ,189 -46. ,157 1.00 29. ,87 L c

ATOM 4623 CB PRO L 80 35. 171 -16. ,134 -45. ,821 1.00 26. ,81 L c

ATOM 4626 CG PRO L 80 36. 113 -16. ,205 -46. ,928 1.00 29. ,99 L C

ATOM 4629 CD PRO L 80 35. 288 -16. ,513 -48. ,163 1.00 28. ,60 L c cyno fD..Fab

ATOM 4632 C PRO L 80 32. ,791 -16. 761 -45. 574 1.00 31.54 L C

ATOM 4633 O PRO L 80 32. 387 -17. 290 -44. 550 1.00 28.23 L 0

ATOM 4634 N GLU L 81 32. 152 -15. 786 -46. ,224 1.00 34.23 L N

ATOM 4635 CA GLU L 81 30. 927 -15. 161 -45. ,726 1.00 31.10 L C

ATOM 4637 CB GLU L 81 30. 699 -13. 793 -46. ,401 1.00 35.25 L C

ATOM 4640 CG GLU L 81 30. ,471 -13. 822 -47. ,925 1.00 41.26 L C

ATOM 4643 CD GLU L 81 31. 736 -13. 539 -48. ,758 1.00 48.81 L c

ATOM 4644 OEl GLU L 81 32. ,877 -13. 879 -48. ,316 1.00 46.11 L 0

ATOM 4645 OE2 GLU L 81 31. 574 -12. 971 -49. 868 1.00 50.23 L 0

ATOM 4646 C GLU L 81 29. 670 -16. 005 -45. ,876 1.00 30.04 L c

ATOM 4647 O GLU L 81 28. 613 -15. 581 -45. ,428 1.00 30.78 L 0

ATOM 4649 N ASP L 82 29. 786 -17. ,180 -46. ,505 1.00 29.44 L N

ATOM 4650 CA ASP L 82 28. ,675 -18. 126 -46. ,677 1.00 25.79 L c

ATOM 4652 CB ASP L 82 28. ,875 -18. 998 -47. ,930 1.00 23.56 L c

ATOM 4655 CG ASP L 82 28. ,988 -18. 187 -49. ,215 1.00 26.90 L c

ATOM 4656 ODl ASP L 82 28. 553 -17. 021 -49. ,208 1.00 21.54 L 0

ATOM 4657 002 ASP L 82 29. 517 -18. 714 -50. ,236 1.00 23.70 L 0

ATOM 4658 C ASP L 82 28. 474 -19. 049 -45. ,470 1.00 24.57 L c

ATOM 4659 0 ASP L 82 27. 581 -19. 884 -45. ,480 1.00 27.04 L 0

ATOM 4661 N VAL L 83 29. 296 -18. 916 -44. ,435 1.00 27.35 L N

ATOM 4662 CA VAL L 83 29. 106 -19. 707 -43. 226 1.00 27.74 L C

ATOM 4664 CB VAL L 83 30. 203 -19. ,415 -42. ,182 1.00 32.22 L c

ATOM 4666 CGI VAL L 83 29. 820 -19. 926 -40. ,798 1.00 27.26 L c

ATOM 4670 CG2 VAL L 83 31. 496 -20. 057 -42. ,641 1.00 33.24 L c

ATOM 4674 C VAL L 83 27. 722 -19. 398 -42. ,683 1.00 26.93 L c

ATOM 4675 0 VAL L 83 27. 407 -18. 246 -42. ,412 1.00 32.44 L 0

ATOM 4677 N ALA L 84 26. 893 -20. 436 -42. ,575 1.00 23.63 L N

ATOM 4678 CA ALA L 84 25. 511 -20. 313 -42. 099 1.00 24.43 L c

ATOM 4680 CB ALA L 84 24. 689 -19. 491 -43. 076 1.00 23.14 L c

ATOM 4684 C ALA L 84 24. 916 -21. 702 -41.980 1.00 21.75 L c

ATOM 4685 0 ALA L 84 25. 561 -22. 685 -42. ,324 1.00 26.64 L 0

ATOM 4687 N THR L 85 23. 680 -21. 775 -41.487 1.00 25.41 L N

ATOM 4688 CA THR L 85 22. 853 -22. 969 -41. 586 1.00 21.03 L c

ATOM 4690 CB THR L 85 22. 156 -23. 259 -40. ,215 1.00 23.99 L c

ATOM 4692 OGl THR L 85 23. 161 -23. 385 -39. 208 1.00 21.81 L 0

ATOM 4694 CG2 THR L 85 21. 325 -24. 566 -40. ,249 1.00 19.42 L c

ATOM 4698 C THR L 85 21. 853 -22. 668 -42. ,702 1.00 23.60 L c

ATOM 4699 0 THR L 85 21.215 -21. 615 -42. ,676 1.00 15.27 L 0

ATOM 4701 N TYR L 86 21. 794 -23. 533 -43. ,728 1.00 24.17 L N

ATOM 4702 CA TYR L 86 20. 835 -23. 406 -44. ,828 1.00 21.47 L C

ATOM 4704 CB TYR L 86 21. 484 -23. 703 -46. 189 1.00 22.59 L C

ATOM 4707 CG TYR L 86 22. 579 -22. 738 -46. ,468 1.00 21.53 L C

ATOM 4708 CDl TYR L 86 22. 337 -21. 574 -47. ,186 1.00 23.29 L C

ATOM 4710 CEl TYR L 86 23. 353 -20. 645 -47. ,406 1.00 25.30 L c

ATOM 4712 cz TYR L 86 24. 626 -20. 883 -46. ,895 1.00 24.87 L c

ATOM 4713 OH TYR L 86 25. 628 -19. ,967 -47. ,102 1.00 26.31 L 0

ATOM 4715 CE2 TYR L 86 24. 874 -22. ,012 -46. ,148 1.00 21.74 L c

ATOM 4717 CD2 TYR L 86 23. 856 -22. 946 -45. ,958 1.00 21.76 L c

ATOM 4719 C TYR L 86 19. 606 -24. 295 -44. ,616 1.00 20.27 L c

ATOM 4720 0 TYR L 86 19. 735 -25. 436 -44. ,196 1.00 20.94 L 0

ATOM 4722 N TYR L 87 18. 424 -23. 739 -44. ,897 1.00 23.56 L N

ATOM 4723 CA TYR L 87 17. 139 -24. 444 -44. ,758 1.00 19.01 L c

ATOM 4725 CB TYR L 87 16. 279 -23. 818 -43. ,675 1.00 21.93 L c

ATOM 4728 CG TYR L 87 16. ,903 -23. ,785 -42. ,307 1.00 20.93 L c

ATOM 4729 CDl TYR L 87 16. 673 -24. ,793 -41. ,388 1.00 19.04 L c

ATOM 4731 CEl TYR L 87 17. 250 -24. ,743 -40. ,124 1.00 24.45 L c

ATOM 4733 CZ TYR L 87 18. 063 -23. ,677 -39. ,785 1.00 21.60 L c

ATOM 4734 OH TYR L 87 18. 631 -23. ,602 -38. ,531 1.00 23.99 L 0

ATOM 4736 CE2 TYR L 87 18. 289 -22. 666 -40. ,683 1.00 16.99 L c

ATOM 4738 CD2 TYR L 87 17. 719 -22. ,723 -41. ,928 1.00 21.05 L c

ATOM 4740 C TYR L 87 16. 357 -24. ,417 -46. ,057 1.00 20.23 L c

ATOM 4741 0 TYR L 87 16. 213 -23. 364 -46. ,670 1.00 23.11 L 0

ATOM 4743 N CYS L 88 15. 862 -25. ,574 -46. .496 1.00 23.95 L N

ATOM 4744 CA CYS L 88 14. 891 -25. ,592 -47. ,604 1.00 25.00 L c

ATOM 4746 CB CYS L 88 14. 879 -26. 910 -48. ,351 1.00 27.66 L c

ATOM 4749 SG CYS L 88 14. 494 -28. ,421 -47. ,396 1.00 30.09 L S

ATOM 4751 C CYS L 88 13. 526 -25. ,372 -46. ,992 1.00 21.79 L c

ATOM 4752 0 CYS L 88 13. 344 -25. ,610 -45. ,801 1.00 17.37 L 0 cyno fD_Fab

ATOM 4754 N LEU L 89 12 579 -24 894 -47 791 1.00 23 22 L N

ATOM 4755 CA LEU L 89 11 170 -24. 803 -47 341 1.00 20. 80 L C

ATOM 4757 CB LEU L 89 10 827 -23 396 -46 837 1.00 20. 57 L C

ATOM 4760 CG LEU L 89 9 342 -23 146 -46 470 1.00 18. 93 L c

ATOM 4762 CDl LEU L 89 9 163 -23 007 -44 979 1.00 18. 18 L c

ATOM 4766 CD2 LEU L 89 8 792 -21. 925 -47 217 1.00 17. 36 L c

ATOM 4770 C LEU L 89 10 249 -25. 167 -48 492 1.00 19. 93 L c

ATOM 4771 O LEU L 89 10 400 -24. 658 -49 603 1.00 18. 43 L 0

ATOM 4773 N GLN L 90 9 292 -26. 050 -48 214 1.00 20. 22 L N

ATOM 4774 CA GLN L 90 8 326 -26 456 -49 212 1.00 23. 91 L c

ATOM 4776 CB GLN L 90 7 775 -27 883 -48 951 1.00 21. 99 L c

ATOM 4779 CG GLN L 90 6 267 -28 041 -49 324 1.00 25. 60 L c

ATOM 4782 CD GLN L 90 5 358 -27. 873 -48 171 1.00 30. 23 L c

ATOM 4783 OEl GLN L 90 5 706 -28. 204 -47 058 1.00 36. 99 L 0

ATOM 4784 NE2 GLN L 90 4 167 -27. 412 -48 427 1.00 40. 71 L N

ATOM 4787 C GLN L 90 7 219 -25. 437 -49 168 1.00 19. 47 L c

ATOM 4788 O GLN L 90 6 689 -25. 147 -48 087 1.00 17. 07 L 0

ATOM 4790 N SER L 91 6 825 -24. 930 -50 345 1.00 23. 64 L N

ATOM 4791 CA SER L 91 5 670 -24. 042 -50 408 1.00 25. 08 L c

ATOM 4793 CB SER L 91 6 134 -22. 579 -50 477 1.00 22. 90 L c

ATOM 4796 OG SER L 91 6 537 -22. 208 -51 759 1.00 15. 46 L 0

ATOM 4798 C SER L 91 4 587 -24. 410 -51 461 1.00 25. 06 L c

ATOM 4799 O SER L 91 3 944 -23. 549 -52 047 1.00 26. 38 L 0

ATOM 4801 N ASP L 92 4 335 -25. 706 -51 598 1.00 25. 61 L N

ATOM 4802 CA ASP L 92 3 308 -26. 249 -52 478 1.00 24. 49 L c

ATOM 4804 CB ASP L 92 3 499 -27. 778 -52 549 1.00 23. 52 L c

ATOM 4807 CG ASP L 92 2 297 -28. 496 -53 109 1.00 27. 32 L c

ATOM 4808 ODl ASP L 92 2 246 -28. 712 -54 337 1.00 25. 72 L 0

ATOM 4809 OD2 ASP L 92 1 393 -28. 816 -52 309 1.00 21. 92 L 0

ATOM 4810 C ASP L 92 1 862 -25. 922 -52 022 1.00 26. 36 L c

ATOM 4811 O ASP L 92 0 942 -25. 737 -52 819 1.00 23. 83 L 0

ATOM 4813 N SER L 93 1 676 -25. 869 -50 722 1.00 25. 09 L N

ATOM 4814 CA SER L 93 0 370 -25. 729 -50 151 1.00 19. 22 L c

ATOM 4816 CB SER L 93 -0 448 -26. 996 -50 399 1.00 15. 50 L c

ATOM 4819 OG SER L 93 0 253 -28. 204 -50 054 1.00 13. 07 L 0

ATOM 4821 C SER L 93 0 622 -25. 528 -48 669 1.00 23. 85 L c

ATOM 4822 O SER L 93 1 726 -25. 816 -48 173 1.00 25. 31 L 0

ATOM 4824 N LEU L 94 -0 385 -25. 039 -47 969 1.00 22. 99 L N

ATOM 4825 CA LEU L 94 -0 290 -24. 815 -46 538 1.00 20. 48 L c

ATOM 4827 CB LEU L 94 -1 277 -23. 739 -46 106 1.00 21. 67 L c

ATOM 4830 CG LEU L 94 -1 175 -22. 301 -46 616 1.00 18. 21 L c

ATOM 4832 CDl LEU L 94 -2 473 -21. 569 -46 210 1.00 18. 76 L c

ATOM 4836 CD2 LEU L 94 0 062 -21. 568 -46 074 1.00 12. 37 L c

ATOM 4840 C LEU L 94 -0 603 -26. 093 -45 770 1.00 21. 17 L c

ATOM 4841 0 LEU L 94 -1 536 -26. 804 -46 113 1.00 26. 26 L 0

ATOM 4843 N PRO L 95 0 127 -26. 365 -44 680 1.00 21. 53 L N

ATOM 4844 CA PRO L 95 1 184 -25. 560 -44 119 1.00 19. 46 L C

ATOM 4846 CB PRO L 95 1 240 -26. 047 -42 678 1.00 23. 51 L C

ATOM 4849 CG PRO L 95 0 888 -27. 469 -42 771 1.00 23. 20 L c

ATOM 4852 CD PRO L 95 -0 100 -27. 582 -43 880 1.00 22. 93 L c

ATOM 4855 C PRO L 95 2 514 -25. 805 -44 835 1.00 18. 19 L c

ATOM 4856 0 PRO L 95 2 767 -26. 910 -45 313 1.00 22. 86 L 0

ATOM 4857 N TYR L 96 3 340 -24. 766 -44 918 1.00 16. 10 L N

ATOM 4858 CA TYR L 96 4 697 -24. 906 -45 420 1.00 21. 13 L C

ATOM 4860 CB TYR L 96 5 360 -23. 545 -45 684 1.00 15. 78 L C

ATOM 4863 CG TYR L 96 4 678 -22. 611 -46 654 1.00 11. 35 L c

ATOM 4864 CDl TYR L 96 3 664 -23. 033 -47 494 1.00 13. 34 L c

ATOM 4866 CEl TYR L 96 3 069 -22. 164 -48 359 1.00 14. 62 L c

ATOM 4868 CZ TYR L 96 3 485 -20. 843 -48 419 1.00 15. 70 L c

ATOM 4869 OH TYR L 96 2 891 -19. 960 -49 305 1.00 15. 51 L 0

ATOM 4871 CE2 TYR L 96 4 507 -20. 403 -47 599 1.00 12. 39 L c

ATOM 4873 CD2 TYR L 96 5 081 -21.273 -46 731 1.00 13. 42 L c

ATOM 4875 C TYR L 96 5 549 -25. 704 -44 421 1.00 16. 48 L c

ATOM 4876 0 TYR L 96 5 167 -25. 940 -43 277 1.00 20. 41 L 0

ATOM 4878 N THR L 97 6 720 -26. 115 -44 869 1.00 22. 03 L N

ATOM 4879 CA THR L 97 7 535 -27. 059 -44 116 1.00 20. 39 L c

ATOM 4881 CB THR L 97 7 147 -28. 506 -44 492 1.00 17. 47 L c

ATOM 4883 OGl THR L 97 5 710 -28. 624 -44 513 1.00 17. 34 L 0 cyno fD_Fab

ATOM 4885 CG2 THR L 97 7. ,737 -29. 498 -43. ,525 1. 00 14. 07 L C

ATOM 4889 C THR L 97 9. ,012 -26. 812 -44. ,420 1.00 24. 61 L C

ATOM 4890 O THR L 97 9. ,431 -26. 867 -45. ,573 1.00 19. 22 L 0

ATOM 4892 N PHE L 98 9. ,777 -26. 527 -43. ,366 1. 00 26. 06 L N

ATOM 4893 CA PHE L 98 11. 219 -26. 310 -43. ,456 1.00 25. 08 L C

ATOM 4895 CB PHE L 98 11. ,696 -25. ,473 -42. ,229 1. 00 22. 13 L C

ATOM 4898 CG PHE L 98 11. 561 -23. 987 -42. ,401 1.00 20. 61 L C

ATOM 4899 CDl PHE L 98 12. 375 -23. 306 -43. ,306 1. 00 18. 98 L c

ATOM 4901 CEl PHE L 98 12. ,257 -21. 933 -43. ,474 1.00 21. 34 L c

ATOM 4903 CZ PHE L 98 11.323 -21. 223 -42. 711 1. 00 24. 27 L c

ATOM 4905 CE2 PHE L 98 10. 519 -21. 895 -41. ,801 1.00 17. 37 L c

ATOM 4907 CD2 PHE L 98 10. 645 -23. 262 -41. ,650 1. 00 17. 21 L c

ATOM 4909 C PHE L 98 11. 957 -27. 647 -43. ,462 1.00 22. 27 L c

ATOM 4910 O PHE L 98 11. ,534 -28. 607 -42. ,830 1.00 20. 00 L 0

ATOM 4912 N GLY L 99 13. ,085 -27. 710 -44. ,154 1.00 29. 73 L N

ATOM 4913 CA GLY L 99 14. 056 -28. 751 -43. ,874 1.00 24. 02 L c

ATOM 4916 C GLY L 99 14. 630 -28. 647 -42. ,460 1.00 25. 54 L c

ATOM 4917 O GLY L 99 14. 463 -27. 632 -41.747 1.00 24. 47 L 0

ATOM 4919 N GLN L 100 15. 355 -29. 689 -42. ,071 1. 00 26. 67 L N

ATOM 4920 CA GLN L 100 15. 973 -29. 758 -40. ,750 1.00 22. 86 L c

ATOM 4922 CB GLN L 100 16. 353 -31. 187 -40. ,395 1.00 21. 01 L c

ATOM 4925 CG GLN L 100 15. 206 -32. 163 -40. ,385 1.00 20. 47 L c

ATOM 4928 CD GLN L 100 14. 817 -32. 697 -41. ,766 1.00 27. 97 L c

ATOM 4929 OEl GLN L 100 15. 419 -32. 362 -42. ,813 1.00 23. 15 L 0

ATOM 4930 NE2 GLN L 100 13. 807 -33. 544 -41. ,772 1. 00 35. 92 L N

ATOM 4933 C GLN L 100 17. 214 -28. 887 -40. ,624 1.00 20. 93 L c

ATOM 4934 O GLN L 100 17. 659 -28. 627 -39. ,509 1.00 22. 08 L 0

ATOM 4936 N GLY L 101 17. 758 -28. 426 -41. ,751 1.00 22. 71 L N

ATOM 4937 CA GLY L 101 18. 910 -27. 536 -41. ,740 1.00 24. 60 L c

ATOM 4940 C GLY L 101 20. 200 -28. 246 -42. ,101 1.00 26. 13 L c

ATOM 4941 O GLY L 101 20. 359 -29. 428 -41. ,841 1.00 29. 65 L 0

ATOM 4943 N THR L 102 21. 107 -27. 512 -42. ,730 1. 00 26. 36 L N

ATOM 4944 CA THR L 102 22. 457 -27. 981 -42. ,989 1.00 26. 55 L c

ATOM 4946 CB THR L 102 22. 739 -28. 249 -44. ,467 1. 00 23. 82 L c

ATOM 4948 OG1 THR L 102 21. 825 -29. 229 -44. ,975 1.00 25. 68 L 0

ATOM 4950 CG2 THR L 102 24. 186 -28. 736 -44. ,625 1. 00 22. 53 L c

ATOM 4954 C THR L 102 23. 435 -26. 896 -42. ,556 1.00 23. 62 L c

ATOM 4955 O THR L 102 23. 494 -25. 851 -43. ,172 1.00 21. 90 L 0

ATOM 4957 N LYS L 103 24. 221 -27. 190 -41. ,531 1.00 21. 31 L N

ATOM 4958 CA LYS L 103 25. 229 -26. 283 -41. ,029 1.00 25. 59 L c

ATOM 4960 CB LYS L 103 25. 641 -26. 707 -39. ,623 1.00 25. 58 L c

ATOM 4963 CG LYS L 103 26. 339 -25. 629 -38. ,818 1. 00 26. 60 L c

ATOM 4966 CD LYS L 103 27. 012 -26. 211 -37. ,606 1.00 28. 54 L c

ATOM 4969 CE LYS L 103 27. 748 -25. 150 -36. ,762 1. 00 33. 51 L c

ATOM 4972 NZ LYS L 103 26. 813 -24. 170 -36. ,109 1.00 38. 27 L N

ATOM 4976 C LYS L 103 26. 413 -26. ,321 -41. ,986 1.00 25. 33 L c

ATOM 4977 O LYS L 103 26. 975 -27. ,381 -42. ,257 1.00 24. 17 L 0

ATOM 4979 N VAL L 104 26. 762 -25. 176 -42. ,552 1.00 28. 43 L N

ATOM 4980 CA VAL L 104 27. 904 -25. 118 -43. ,455 1.00 24. 98 L C

ATOM 4982 CB VAL L 104 27. 536 -24. 423 -44. ,767 1.00 21. 05 L c

ATOM 4984 CGl VAL L 104 28. 769 -24. 286 -45. ,694 1.00 20. 66 L C

ATOM 4988 CG2 VAL L 104 26. 422 -25. 181 -45. ,431 1.00 13. 60 L C

ATOM 4992 C VAL L 104 29. 036 -24. 397 -42. ,741 1. 00 33. 08 L c

ATOM 4993 O VAL L 104 28. 844 -23. 304 -42. ,194 1.00 28. 61 L 0

ATOM 4995 N GLU L 105 30. 209 -25. 033 -42. ,721 1.00 33. 88 L N

ATOM 4996 CA GLU L 105 31. 397 -24. ,457 -42. ,117 1. 00 31. 05 L c

ATOM 4998 CB GLU L 105 31. 745 -25. 192 -40. ,813 1.00 34. 83 L c

ATOM 5001 CG GLU L 105 31. 069 -24. 521 -39. ,580 1.00 41. 04 L c

ATOM 5004 CD GLU L 105 31. 110 -25. 338 -38. ,288 1.00 39. 98 L c

ATOM 5005 OEl GLU L 105 30. 890 -26. 575 -38. ,328 1.00 42. 49 L 0

ATOM 5006 OE2 GLU L 105 31. 340 -24. 715 -37. ,224 1. 00 40. 83 L 0

ATOM 5007 C GLU L 105 32. ,539 -24. ,437 -43. .133 1.00 27. 77 L c

ATOM 5008 O GLU L 105 32. 572 -25. ,249 -44. ,061 1.00 23. 32 L 0

ATOM 5010 N ILE L 106 33. 422 -23. ,446 -43. ,021 1.00 32. 10 L N

ATOM 5011 CA ILE L 106 34. 573 -23. ,352 -43. ,921 1. 00 33. 37 L c

ATOM 5013 CB ILE L 106 35. 003 -21.900 -44. ,232 1.00 35. 53 L c

ATOM 5015 CGl ILE L 106 34. 126 -21.295 -45. ,324 1.00 37. 32 L c

ATOM 5018 CDl ILE L 106 32. 684 -21. 139 -44. ,935 1.00 40. 30 L c cyno fD_Fab

ATOM 5022 CG2 ILE L 106 36. .446 -21. 860 -44. 740 1. 00 31. 85 L C

ATOM 5026 C ILE L 106 35. ,750 -24. 086 -43. 307 1. 00 33. 88 L c

ATOM 5027 0 ILE L 106 36. ,030 -23. 921 -42. 114 1. 00 34. 44 L 0

ATOM 5029 N LYS L 107 36. ,414 -24. 892 -44. 132 1. 00 34. 53 L N

ATOM 5030 CA LYS L 107 37. ,673 -25. 538 -43. ,785 1. 00 36. ,55 L C

ATOM 5032 CB LYS L 107 37. ,767 -26. 919 -44. ,423 1. 00 39. 43 L C

ATOM 5035 CG LYS L 107 38. ,967 -27. 739 -43. 979 1. 00 40. 06 L c

ATOM 5038 CD LYS L 107 39. ,395 -28. 722 -45. ,055 1. 00 40. ,37 L c

ATOM 5041 CE LYS L 107 40. ,760 -29. 291 -44. 764 1. 00 42. ,50 L c

ATOM 5044 NZ LYS L 107 40. 725 -30. 003 -43. ,464 1. 00 40. 70 L N

ATOM 5048 C LYS L 107 38. 842 -24. 671 -44. 249 1. 00 35. 86 L c

ATOM 5049 0 LYS L 107 38. ,970 -24. 336 -45. 428 1. 00 26. 08 L 0

ATOM 5051 N ARG L 108 39. ,711 -24. 371 -43. 290 1. 00 37. 76 L N

ATOM 5052 CA ARG L 108 40. ,700 -23. 314 -43. 368 1. 00 37. 49 L c

ATOM 5054 CB ARG L 108 40. ,206 -22. 256 -42. ,388 1. 00 40. 73 L c

ATOM 5057 CG ARG L 108 40. .968 -20. 994 -42. ,299 1. 00 45. 09 L c

ATOM 5060 CD ARG L 108 41. ,092 -20. 559 -40. 864 1. 00 43. 58 L c

ATOM 5063 NE ARG L 108 41.502 -19. 170 -40. ,808 1. 00 46. 88 L N

ATOM 5065 CZ ARG L 108 42. ,743 -18. 725 -40. ,978 1. 00 46. ,41 L c

ATOM 5066 NHl ARG L 108 43. ,764 -19. 550 -41. 180 1. 00 46. 86 L N

ATOM 5069 NH2 ARG L 108 42. ,960 -17. 421 -40. 923 1. 00 50. 11 L N

ATOM 5072 C ARG L 108 42. ,082 -23. 900 -42. 957 1. 00 36. 21 L C

ATOM 5073 0 ARG L 108 42. ,159 -25. 041 -42. 456 1. 00 33. 63 L 0

ATOM 5075 N THR L 109 43. ,171 -23. 160 -43. ,176 1. 00 31. ,25 L N

ATOM 5076 CA THR L 109 44. ,459 -23. 553 -42. ,604 1. 00 32. 62 L C

ATOM 5078 CB THR L 109 45. ,645 -22. 747 -43. ,189 1. 00 35. ,14 L c

ATOM 5080 OGl THR L 109 45. ,417 -21. 342 -43. ,042 1. 00 34. 81 L 0

ATOM 5082 CG2 THR L 109 45. ,820 -23. 066 -44. 671 1. 00 32. ,20 L c

ATOM 5086 C THR L 109 44. ,420 -23. 435 -41. 077 1. 00 29. ,12 L c

ATOM 5087 0 THR L 109 43. ,619 -22. 702 -40. ,517 1. 00 26. 55 L 0

ATOM 5089 N VAL L 110 45. ,255 -24. 211 -40. ,405 1. 00 33. 31 L N

ATOM 5090 CA VAL L 110 45. ,354 -24. 162 -38. 947 1. 00 34. 24 L c

ATOM 5092 CB VAL L 110 46. ,339 -25. 234 -38. 429 1. 00 33. 83 L c

ATOM 5094 CGl VAL L 110 45. .858 -26. 645 -38. ,858 1. 00 31. ,60 L c

ATOM 5098 CG2 VAL L 110 46. .528 -25. 143 -36. ,910 1. 00 32. ,46 L c

ATOM 5102 C VAL L 110 45. ,796 -22. 762 -38. ,517 1. 00 38. ,28 L c

ATOM 5103 0 VAL L 110 46. ,618 -22. 134 -39. ,189 1. 00 41. 32 L 0

ATOM 5105 N ALA L 111 45. ,214 -22. 264 -37. ,423 1. 00 35. ,55 L N

ATOM 5106 CA ALA L 111 45. ,585 -20. 967 -36. ,856 1. 00 32. 46 L C

ATOM 5108 CB ALA L 111 44. ,602 -19. 869 -37. 280 1. 00 29. ,38 L C

ATOM 5112 C ALA L 111 45. ,601 -21. 099 -35. ,344 1. 00 35. ,67 L C

ATOM 5113 0 ALA L 111 44. ,588 -21. 450 -34. ,742 1. 00 33. ,80 L 0

ATOM 5115 N ALA L 112 46. ,763 -20. 827 -34. ,747 1. 00 37. 38 L N

ATOM 5116 CA ALA L 112 46. ,935 -20. 854 -33. ,298 1. 00 33. ,98 L C

ATOM 5118 CB ALA L 112 48, ,410 -20. 779 -32. ,949 1. 00 35. 33 L c

ATOM 5122 C ALA L 112 46. ,188 -19. 691 -32. ,655 1. 00 33. ,67 L c

ATOM 5123 0 ALA L 112 46. ,151 -18. 596 -33. ,219 1. 00 31.87 L 0

ATOM 5125 N PRO L 113 45. .585 -19. 924 -31.473 1. 00 36. ,10 L N

ATOM 5126 CA PRO L 113 44. .897 -18. 859 -30. ,735 1. 00 35. ,72 L c

ATOM 5128 CB PRO L 113 44. ,075 -19. 628 -29. ,695 1. 00 35. ,75 L c

ATOM 5131 CG PRO L 113 44. ,822 -20. 870 -29. ,473 1. 00 35. ,36 L c

ATOM 5134 CD PRO L 113 45. ,498 -21. 217 -30. ,771 1. 00 35. ,21 L c

ATOM 5137 C PRO L 113 45. ,837 -17. 888 -30. ,026 1. 00 36. ,75 L c

ATOM 5138 0 PRO L 113 46. ,875 -18. ,295 -29. ,502 1. ,00 39. ,60 L 0

ATOM 5139 N SER L 114 45. ,468 -16. 611 -30. ,012 1. ,00 34. ,02 L N

ATOM 5140 CA SER L 114 46. ,127 -15. ,652 -29. ,154 1. ,00 32. ,66 L c

ATOM 5142 CB SER L 114 45. ,929 -14. 232 -29. ,662 1. 00 32. ,42 L c

ATOM 5145 OG SER L 114 46. ,299 -14. 140 -31. ,016 1. 00 34. ,32 L 0

ATOM 5147 C SER L 114 45. ,462 -15. ,803 -27. ,813 1. 00 32. ,10 L c

ATOM 5148 0 SER L 114 44. ,235 -15. 732 -27. ,727 1. 00 32. ,06 L 0

ATOM 5150 N VAL L 115 46. ,256 -16. 003 -26. ,768 1. 00 31. ,87 L N

ATOM 5151 CA VAL L 115 45. ,704 -16. 172 -25. ,433 1. 00 32. ,60 L c

ATOM 5153 CB VAL L 115 46. ,262 -17. ,434 -24. ,732 1. ,00 30. .38 L c

ATOM 5155 CGl VAL L 115 45. ,335 -17. 863 -23. ,609 1. ,00 29. .53 L c

ATOM 5159 CG2 VAL L 115 46. ,415 -18. ,574 -25. ,731 1. ,00 30. ,32 L c

ATOM 5163 C VAL L 115 45. ,944 -14. ,912 -24. ,592 1. 00 34. ,21 L c

ATOM 5164 0 VAL L 115 47. ,060 -14. 391 -24. ,521 1. 00 35. ,31 L 0

ATOM 5166 N PHE L 116 44. ,869 -14. 407 -23. ,997 1. 00 33. ,48 L N cyno fD_Fab

ATOM 5167 CA PHE L 116 44 932 -13 295 -23 068 1 00 33. 33 L C

ATOM 5169 CB PHE L 116 44 206 -12 069 -23 635 1 00 33 . 68 L C

ATOM 5172 CG PHE L 116 44 574 -11 747 -25. 065 1 00 36. 34 L C

ATOM 5173 CDl PHE L 116 45 657 -10 928 -25. 359 1 00 37. 25 L c

ATOM 5175 CEl PHE L 116 46 001 -10 634 -26 684 1 00 35. 21 L c

ATOM 5177 CZ PHE L 116 45 266 -11 163 -27 711 1 00 32. 65 L c

ATOM 5179 CE2 PHE L 116 44 187 -11 981 -27 433 1 00 34. 11 L c

ATOM 5181 CD2 PHE L 116 43 845 -12 271 -26 121 1 00 34. 18 L c

ATOM 5183 C PHE L 116 44 272 -13 756 -21 776 1 00 34. 21 L c

ATOM 5184 O PHE L 116 43 344 -14 561 -21 801 1 00 33 . 93 L 0

ATOM 5186 N ILE L 117 44 765 -13 262 -20. 647 1 00 35. 12 L N

ATOM 5187 CA ILE L 117 44 152 -13 553 -19. 360 1 00 32. 68 L c

ATOM 5189 CB ILE L 117 45 069 -14 439 -18. 462 1 00 33 . 33 L c

ATOM 5191 CGI ILE L 117 44 296 -14 939 -17 239 1 00 30. 66 L c

ATOM 5194 CDl ILE L 117 45 062 -15 915 -16 411 1 00 31. 12 L c

ATOM 5198 CG2 ILE L 117 46 341 -13 694 -18 051 1 00 34. 54 L c

ATOM 5202 C ILE L 117 43 771 -12 237 -18 693 1 00 31. 48 L c

ATOM 5203 O ILE L 117 44 457 -11 225 -18 856 1 00 30. 97 L 0

ATOM 5205 N PHE L 118 42 643 -12 253 -17 987 1 00 31. 51 L N

ATOM 5206 CA PHE L 118 42 112 -11 076 -17 320 1 00 31. 01 L c

ATOM 5208 CB PHE L 118 40 816 -10 588 -17. 978 1 00 31. 07 L c

ATOM 5211 CG PHE L 118 40 965 -10 193 -19. 421 1 00 32. 20 L c

ATOM 5212 CDl PHE L 118 41 280 -8 887 -19. 769 1 00 30. 51 L c

ATOM 5214 CEl PHE L 118 41 411 -8 519 -21 105 1 00 31.53 L c

ATOM 5216 CZ PHE L 118 41 225 -9 460 -22 107 1 00 30. 93 L c

ATOM 5218 CE2 PHE L 118 40.905 -10 766 -21 772 1 00 31.94 L c

ATOM 5220 CD2 PHE L 118 40 774 -11 127 -20 438 1 00 31. 03 L c

ATOM 5222 C PHE L 118 41 789 -11 456 -15 890 1 00 32. 89 L c

ATOM 5223 O PHE L 118 41.017 -12 392 -15 675 1 00 35. 18 L 0

ATOM 5225 N PRO L 119 42 363 -10 732 -14. 911 1 00 29. 28 L N

ATOM 5226 CA PRO L 119 41 968 -10 945 -13. 527 1 00 29. 52 L c

ATOM 5228 CB PRO L 119 43. 092 -10 272 -12. 722 1 00 30. 05 L c

ATOM 5231 CG PRO L 119 43. 655 -9 250 -13. 610 1 00 30. 80 L c

ATOM 5234 CD PRO L 119 43 406 -9 698 -15 037 1 00 29. 96 L c

ATOM 5237 C PRO L 119 40 620 -10 303 -13. 220 1 00 28. 26 L c

ATOM 5238 O PRO L 119 40 119 -9 504 -14 021 1 00 30. 99 L 0

ATOM 5239 N PRO L 120 40 014 -10 671 -12 083 1 00 23. 94 L N

ATOM 5240 CA PRO L 120 38 773 -10 033 -11.686 1 00 28. 24 L c

ATOM 5242 CB PRO L 120 38 333 -10 843 -10 463 1 00 24. 91 L c

ATOM 5245 CG PRO L 120 39 558 -11 444 -9 949 1 00 26. 27 L c

ATOM 5248 CD PRO L 120 40 422 -11 715 -11 132 1 00 23. 97 L c

ATOM 5251 C PRO L 120 38 974 -8 562 -11 328 1 00 31. 32 L c

ATOM 5252 O PRO L 120 40. 056 -8 166 -10 887 1 00 35. 50 L 0

ATOM 5253 N SER L 121 37 930 -7 768 -11 535 1 00 33. 30 L N

ATOM 5254 CA SER L 121 37 959 -6 350 -11 233 1 00 32. 60 L c

ATOM 5256 CB SER L 121 36 800 - 5 657 -11 937 1 00 33 . 35 L c

ATOM 5259 OG SER L 121 35 563 -6 081 -11 391 1 00 32. 63 L 0

ATOM 5261 C SER L 121 37 829 -6 163 -9 729 1 00 34. 97 L c

ATOM 5262 O SER L 121 37 104 -6 910 -9 067 1 00 33 . 63 L 0

ATOM 5264 N ASP L 122 38 522 - 5 165 -9 186 1 00 37. 59 L N

ATOM 5265 CA ASP L 122 38 313 -4 780 -7 792 1 00 36. 41 L c

ATOM 5267 CB ASP L 122 39 114 - 3 527 -7 440 1 00 41.23 L c

ATOM 5270 CG ASP L 122 40 580 - 3 821 -7 217 1 00 45. 91 L c

ATOM 5271 ODl ASP L 122 40 906 -4 526 -6 236 1 00 48 01 L 0

ATOM 5272 OD2 ASP L 122 41 406 - 3 339 -8 019 1 00 48 69 L 0

ATOM 5273 C ASP L 122 36 824 -4 548 -7 557 1 00 33 . 78 L c

ATOM 5274 0 ASP L 122 36 285 -4 940 -6 528 1 00 27. 92 L 0

ATOM 5276 N GLU L 123 36 165 - 3 939 -8 540 1 00 37. 53 L N

ATOM 5277 CA GLU L 123 34 722 - 3 712 -8 500 1 00 39. 09 L c

ATOM 5279 CB GLU L 123 34 263 - 3 119 -9 829 1 00 38. 84 L c

ATOM 5282 CG GLU L 123 32 835 -2 630 -9 813 1 00 41.05 L c

ATOM 5285 CD GLU L 123 32 440 -1 975 -11 111 1 00 44. 35 L c

ATOM 5286 OEl GLU L 123 33 307 -1 853 -12 009 1 00 47. 32 L 0

ATOM 5287 0E2 GLU L 123 31 257 -1 590 -11 230 1 00 46 36 L 0

ATOM 5288 C GLU L 123 33 909 -4 976 -8 194 1 00 38 39 L c

ATOM 5289 0 GLU L 123 32 986 -4 950 -7 377 1 00 39 12 L 0

ATOM 5291 N GLN L 124 34 257 -6 075 -8 852 1 00 38 73 L N

ATOM 5292 CA GLN L 124 33 556 -7 339 -8 651 1 00 38 46 L c cyno fD_Fab

ATOM 5294 CB GLN L 124 33 . ,943 -8. 338 -9. ,731 1. 00 37. ,12 L C

ATOM 5297 CG GLN L 124 33. ,090 -9. 590 -9. ,726 1.00 37. ,31 L C

ATOM 5300 CD GLN L 124 33 . ,580 -10. 631 -10. ,690 1. 00 35. ,85 L C

ATOM 5301 OEl GLN L 124 34. ,568 -10. 432 -11. ,401 1.00 31. ,84 L 0

ATOM 5302 NE2 GLN L 124 32. ,891 -11. 760 -10. ,723 1. 00 39. ,61 L N

ATOM 5305 C GLN L 124 33. 868 -7. 935 -7. 285 1.00 37. ,24 L C

ATOM 5306 O GLN L 124 32. 979 -8. 459 -6. ,612 1. 00 35. ,26 L 0

ATOM 5308 N LEU L 125 35. 138 -7. 853 -6. 896 1.00 38. ,97 L N

ATOM 5309 CA LEU L 125 35. 612 -8. 378 -5. ,611 1. 00 41. ,13 L C

ATOM 5311 CB LEU L 125 37. ,129 -8. ,184 -5. ,477 1.00 40. ,21 L C

ATOM 5314 CG LEU L 125 37. ,969 -8. 990 -6. ,479 1. 00 41. ,05 L C

ATOM 5316 CDl LEU L 125 39. 388 -8. ,455 -6. ,588 1.00 42. ,07 L c

ATOM 5320 CD2 LEU L 125 37. ,985 -10. 466 -6. ,112 1. 00 41. ,28 L c

ATOM 5324 C LEU L 125 34. 871 -7. ,764 -4. ,421 1.00 40. .00 L c

ATOM 5325 O LEU L 125 34. 648 -8. ,446 -3. ,430 1.00 39. ,35 L 0

ATOM 5327 N LYS L 126 34. 461 -6. 498 -4. ,537 1.00 43. .86 L N

ATOM 5328 CA LYS L 126 33. 634 -5. 839 -3. ,507 1.00 49. ,12 L c

ATOM 5330 CB LYS L 126 33. 241 -4. 411 -3. ,924 1. 00 52. ,02 L c

ATOM 5333 CG LYS L 126 34. 377 -3 . 393 -4. ,060 1.00 52. ,80 L c

ATOM 5336 CD LYS L 126 33 . 840 -2. 074 -4. ,661 1. 00 52. ,96 L c

ATOM 5339 CE LYS L 126 34. 895 -1. 296 -5. ,453 1.00 52. ,87 L c

ATOM 5342 NZ LYS L 126 34. 305 -0. 646 -6. ,670 1. 00 51. ,35 L N

ATOM 5346 C LYS L 126 32. 335 -6. 607 -3. ,198 1.00 51. ,79 L C

ATOM 5347 O LYS L 126 31. ,798 -6. 495 -2. ,088 1. 00 54. ,29 L 0

ATOM 5349 N SER L 127 31.827 -7. 354 -4. ,182 1.00 48. ,78 L N

ATOM 5350 CA SER L 127 30. 582 -8. ,117 -4. ,033 1. 00 46. ,85 L C

ATOM 5352 CB SER L 127 29. 758 -8. 037 -5. ,324 1.00 47. ,95 L c

ATOM 5355 OG SER L 127 28. 974 -6. 861 -5. ,321 1.00 47. ,57 L 0

ATOM 5357 C SER L 127 30. 785 -9. 582 -3. 626 1.00 45. ,16 L c

ATOM 5358 O SER L 127 29. 823 -10. 349 -3. ,567 1.00 45. ,98 L 0

ATOM 5360 N GLY L 128 32. 027 -9. 969 -3. ,349 1.00 43. ,56 L N

ATOM 5361 CA GLY L 128 32. 311 -11. 286 -2. ,781 1.00 43. ,85 L c

ATOM 5364 C GLY L 128 32. 530 -12. 396 -3. ,790 1. 00 42. ,43 L c

ATOM 5365 O GLY L 128 32. 705 -13. 559 -3. ,410 1.00 40. ,69 L 0

ATOM 5367 N THR L 129 32. ,537 -12. 042 -5. ,071 1. 00 42. ,97 L N

ATOM 5368 CA THR L 129 32. ,754 -13. 005 -6. ,146 1.00 41.48 L C

ATOM 5370 CB THR L 129 31. ,480 -13. ,171 -7. 008 1. 00 44. ,66 L C

ATOM 5372 OGl THR L 129 30. 706 -11. 960 -6. 970 1.00 46. ,80 L 0

ATOM 5374 CG2 THR L 129 30. 625 -14. 320 -6. ,476 1. 00 44. ,99 L c

ATOM 5378 C THR L 129 33 . 953 -12. 584 -7. 000 1.00 38. ,90 L c

ATOM 5379 O THR L 129 34. 250 -11. 397 -7. 127 1. 00 37. ,99 L 0

ATOM 5381 N ALA L 130 34. 651 -13. ,569 -7. 554 1.00 34. ,10 L N

ATOM 5382 CA ALA L 130 35. 852 -13. 327 -8. 351 1. 00 34. ,29 L c

ATOM 5384 CB ALA L 130 37. 081 -13. 666 -7. 537 1.00 32. ,97 L c

ATOM 5388 C ALA L 130 35. 832 -14. 166 -9. 627 1. 00 32. ,52 L c

ATOM 5389 O ALA L 130 35. ,981 -15. 383 -9. ,556 1.00 33 . .28 L 0

ATOM 5391 N SER L 131 35. ,655 -13. ,517 -10. ,783 1. 00 32. .80 L N

ATOM 5392 CA SER L 131 35. ,678 -14. 197 -12. ,090 1.00 28. .67 L c

ATOM 5394 CB SER L 131 34. ,516 -13. ,724 -12. ,969 1. 00 29. .42 L c

ATOM 5397 OG SER L 131 33 . ,260 -14. ,108 -12. ,442 1.00 32, .08 L 0

ATOM 5399 C SER L 131 36. ,984 -13. ,914 -12. ,827 1.00 30. .09 L c

ATOM 5400 O SER L 131 37. ,304 -12. 758 -13. ,084 1. 00 32. .01 L 0

ATOM 5402 N VAL L 132 37. ,724 -14. 969 -13. ,171 1.00 29. ,43 L N

ATOM 5403 CA VAL L 132 38. ,941 -14. ,855 -13. ,969 1.00 23. ,98 L c

ATOM 5405 CB VAL L 132 40. 074 -15. ,739 -13. ,410 1.00 19. ,16 L c

ATOM 5407 CGI VAL L 132 41.359 -15. ,521 -14. ,202 1.00 15. ,32 L c

ATOM 5411 CG2 VAL L 132 40. 303 -15. ,477 -11. ,894 1. 00 8. ,18 L c

ATOM 5415 C VAL L 132 38. 626 -15. ,314 -15. .390 1.00 26, .45 L c

ATOM 5416 O VAL L 132 38. ,149 -16. ,430 -15. ,593 1.00 26. .84 L 0

ATOM 5418 N VAL L 133 38. ,879 -14. ,463 -16. ,378 1. 00 26, .93 L N

ATOM 5419 CA VAL L 133 38. 563 -14. ,812 -17. ,755 1. 00 26, .98 L c

ATOM 5421 CB VAL L 133 37. 728 -13. ,716 -18. ,440 1.00 25, .98 L c

ATOM 5423 CGI VAL L 133 37. 400 -14. ,104 -19. .866 1. 00 23. .24 L c

ATOM 5427 CG2 VAL L 133 36. 440 -13. ,464 -17. ,653 1. 00 26, .22 L c

ATOM 5431 C VAL L 133 39. 837 -15. ,133 -18. ,551 1.00 28. .09 L c

ATOM 5432 O VAL L 133 40. 837 -14. ,432 -18. ,456 1. 00 27. .16 L 0

ATOM 5434 N CYS L 134 39. ,791 -16. 221 -19. ,310 1. 00 30. .80 L N

ATOM 5435 CA CYS L 134 40. 849 -16. ,584 -20. ,245 1. 00 32. ,10 L C cyno fD_Fab

ATOM 5437 CB CYS L 134 41.373 -17. ,997 -19. ,921 1. 00 35. ,55 L C

ATOM 5440 SG CYS L 134 42.750 -18. ,626 -20. ,943 1. 00 35. ,42 L S

ATOM 5442 C CYS L 134 40.243 -16. ,510 -21. ,647 1. 00 31. ,78 L c

ATOM 5443 O CYS L 134 39.175 -17. .067 -21.893 1. 00 31. ,25 L 0

ATOM 5445 N LEU L 135 40.900 -15. ,787 -22. ,552 1. 00 30. ,96 L N

ATOM 5446 CA LEU L 135 40.397 -15. ,604 -23. ,913 1. 00 29. ,66 L c

ATOM 5448 CB LEU L 135 40.260 -14. ,107 -24. ,249 1. 00 30. ,58 L c

ATOM 5451 CG LEU L 135 40.093 -13. ,684 -25. ,726 1. 00 27. ,39 L c

ATOM 5453 CDl LEU L 135 38.713 -14. ,047 -26. 252 1. 00 24. ,65 L c

ATOM 5457 CD2 LEU L 135 40.348 -12. ,186 -25. ,888 1. 00 25. ,57 L c

ATOM 5461 C LEU L 135 41.334 -16. ,253 -24. ,904 1. 00 31. ,10 L c

ATOM 5462 O LEU L 135 42.533 -15. ,981 -24. ,879 1. 00 31. ,87 L 0

ATOM 5464 N LEU L 136 40.777 -17. ,113 -25, ,761 1. 00 30. ,69 L N

ATOM 5465 CA LEU L 136 41.466 -17. ,652 -26. ,927 1. 00 30. 68 L c

ATOM 5467 CB LEU L 136 41.264 -19. ,162 -27. ,038 1. 00 31. 92 L c

ATOM 5470 CG LEU L 136 41.891 -20. ,120 -26. ,032 1. 00 29. 90 L c

ATOM 5472 CDl LEU L 136 41.357 -19. ,906 -24. ,647 1. 00 27. ,24 L c

ATOM 5476 CD2 LEU L 136 41.604 -21. ,542 -26. ,521 1. 00 28. 08 L c

ATOM 5480 C LEU L 136 40.859 -17. ,006 -28. ,165 1. 00 27. 05 L c

ATOM 5481 O LEU L 136 39.698 -17. ,228 -28. ,467 1. 00 28. ,40 L 0

ATOM 5483 N ASN L 137 41.649 -16. ,230 -28. ,890 1. 00 26. ,10 L N

ATOM 5484 CA ASN L 137 41.137 -15. ,428 -29. ,976 1. 00 31.76 L c

ATOM 5486 CB ASN L 137 41.567 -13. ,968 -29. ,790 1. 00 34. ,39 L c

ATOM 5489 CG ASN L 137 40.542 -12. ,978 -30. ,316 1. 00 40. ,34 L c

ATOM 5490 ODl ASN L 137 39.345 -13. ,138 -30. ,104 1. 00 45. 63 L 0

ATOM 5491 ND2 ASN L 137 41.012 -11. ,936 -30. ,987 1. 00 44. ,01 L N

ATOM 5494 C ASN L 137 41.610 -15. ,946 -31.324 1. 00 29. ,12 L c

ATOM 5495 O ASN L 137 42.785 -16. ,239 -31. ,495 1. 00 30. 93 L 0

ATOM 5497 N ASN L 138 40.672 -16. ,069 -32. ,261 1. 00 31. 33 L N

ATOM 5498 CA ASN L 138 40.963 -16, ,334 -33. ,684 1. 00 32. ,35 L c

ATOM 5500 CB ASN L 138 41.600 -15. ,097 -34. ,322 1. 00 34. ,92 L c

ATOM 5503 CG ASN L 138 40.653 -13. ,920 -34. ,324 1. 00 40. ,18 L c

ATOM 5504 ODl ASN L 138 39.964 -13. ,675 -33. ,333 1. 00 41. ,86 L 0

ATOM 5505 ND2 ASN L 138 40.572 -13. ,209 -35. ,453 1. 00 46. ,55 L N

ATOM 5508 C ASN L 138 41.752 -17. ,592 -34. ,011 1. 00 31. ,07 L c

ATOM 5509 O ASN L 138 42.846 -17. ,538 -34. ,591 1. 00 31. ,28 L 0

ATOM 5511 N PHE L 139 41.159 -18. ,735 -33. ,682 1. 00 34. 20 L N

ATOM 5512 CA PHE L 139 41.803 -20. ,023 -33. ,927 1. 00 31.93 L c

ATOM 5514 CB PHE L 139 42.160 -20. ,712 -32. ,595 1. 00 29. 86 L c

ATOM 5517 CG PHE L 139 40.978 -21.013 -31. ,711 1. 00 25. ,59 L c

ATOM 5518 CDl PHE L 139 40.382 -22. ,259 -31. ,734 1. 00 27. ,08 L c

ATOM 5520 CEl PHE L 139 39.301 -22. ,550 -30. ,925 1. 00 27. ,23 L c

ATOM 5522 CZ PHE L 139 38.809 -21. ,594 -30. ,069 1. 00 29. ,99 L c

ATOM 5524 CE2 PHE L 139 39.404 -20. ,348 -30. ,026 1. 00 29. ,04 L c

ATOM 5526 CD2 PHE L 139 40.485 -20. ,065 -30. ,841 1. 00 30. ,60 L c

ATOM 5528 C PHE L 139 40.993 -20. ,953 -34. ,827 1. 00 30. ,16 L c

ATOM 5529 0 PHE L 139 39.766 -20. .924 -34, ,852 1. 00 33. ,80 L 0

ATOM 5531 N TYR L 140 41.714 -21. ,754 -35, .598 1. 00 34. ,42 L N

ATOM 5532 CA TYR L 140 41.138 -22. .860 -36, .349 1. 00 32. ,43 L c

ATOM 5534 CB TYR L 140 40.916 -22. ,480 -37. .822 1. 00 34. 39 L c

ATOM 5537 CG TYR L 140 40.170 -23. ,554 -38. ,564 1. 00 33. ,08 L c

ATOM 5538 CDl TYR L 140 38.788 -23. ,590 -38. .545 1. 00 33. 79 L c

ATOM 5540 CEl TYR L 140 38.088 -24. ,595 -39. ,201 1. 00 33. ,57 L c

ATOM 5542 CZ TYR L 140 38.778 -25. ,589 -39. ,851 1. 00 33. ,70 L c

ATOM 5543 OH TYR L 140 38.066 -26. ,584 -40. ,477 1. 00 37. ,54 L 0

ATOM 5545 CE2 TYR L 140 40.163 -25. ,599 -39, .855 1. 00 33. ,95 L c

ATOM 5547 CD2 TYR L 140 40.850 -24. ,587 -39, .207 1. 00 32. ,87 L c

ATOM 5549 C TYR L 140 42.058 -24. .080 -36, .232 1. 00 31.20 L c

ATOM 5550 0 TYR L 140 43.282 -23. ,953 -36, ,304 1. 00 35. ,48 L 0

ATOM 5552 N PRO L 141 41.485 -25. .273 -36, ,029 1. 00 33. ,64 L N

ATOM 5553 CA PRO L 141 40.074 -25. ,644 -35, .872 1. 00 34. ,11 L c

ATOM 5555 CB PRO L 141 40.076 -27. ,149 -36, .189 1. 00 35. ,31 L c

ATOM 5558 CG PRO L 141 41.448 -27. ,620 -35. .814 1. 00 32. ,55 L c

ATOM 5561 CD PRO L 141 42.378 -26. .447 -35, .957 1. 00 33. ,34 L c

ATOM 5564 C PRO L 141 39.479 -25, .373 -34, .483 1. 00 32. ,63 L c

ATOM 5565 0 PRO L 141 40.188 -24. .958 -33, ,561 1. 00 32. ,58 L 0

ATOM 5566 N ARG L 142 38.178 -25. .622 -34, .356 1. 00 35. ,34 L N

ATOM 5567 CA ARG L 142 37.399 -25. .308 -33, .155 1. 00 38. ,47 L c cyno fD_Fab

ATOM 5569 CB ARG L 142 35. ,914 -25. 630 -33. .404 1.00 45. 00 L C

ATOM 5572 CG ARG L 142 34. 968 -25. 130 -32. ,299 1.00 45. 82 L C

ATOM 5575 CD ARG L 142 33. ,498 -25. 386 -32, ,624 1.00 50. 55 L C

ATOM 5578 NE ARG L 142 32. ,677 -25. 380 -31. ,407 1.00 55. 04 L N

ATOM 5580 CZ ARG L 142 31. ,351 -25. 542 -31. ,374 1.00 60. 18 L C

ATOM 5581 NHl ARG L 142 30. 655 -25. 719 -32. ,499 1.00 61. 78 L N

ATOM 5584 NH2 ARG L 142 30. 709 -25. 529 -30.203 1.00 57. 67 L N

ATOM 5587 C ARG L 142 37. 846 -26. 001 -31. ,870 1.00 37. 08 L C

ATOM 5588 O ARG L 142 37. 601 -25. 485 -30. ,770 1.00 39. 36 L 0

ATOM 5590 N GLU L 143 38. 484 -27. 163 -32. ,000 1.00 40. 01 L N

ATOM 5591 CA GLU L 143 38. 883 -27. 970 -30. ,843 1.00 38. 63 L C

ATOM 5593 CB GLU L 143 39. 246 -29. 405 -31. ,251 1.00 43. 07 L C

ATOM 5596 CG GLU L 143 38. ,102 -30. 205 -31. ,862 1.00 44. 07 L C

ATOM 5599 CD GLU L 143 38. ,095 -30. 167 -33. ,383 1.00 47. 20 L c

ATOM 5600 OEl GLU L 143 39. 166 -30. 386 -34. ,006 1.00 48. 86 L 0

ATOM 5601 OE2 GLU L 143 37. Oil -29. 939 -33. ,955 1.00 45. 72 L 0

ATOM 5602 C GLU L 143 40. 069 -27. 338 -30. ,133 1.00 36. 32 L c

ATOM 5603 O GLU L 143 41. 086 -27. 046 -30. ,753 1.00 33. 72 L 0

ATOM 5605 N ALA L 144 39. 907 -27. 136 -28. ,830 1.00 34. 19 L N

ATOM 5606 CA ALA L 144 40. 903 -26. 504 -27. ,983 1.00 39. 37 L c

ATOM 5608 CB ALA L 144 40. 823 -24. 984 -28. ,102 1.00 37. 46 L c

ATOM 5612 C ALA L 144 40. 625 -26. 937 -26. ,553 1.00 39. 28 L c

ATOM 5613 O ALA L 144 39. 467 -26. 985 -26. ,139 1.00 42. 41 L 0

ATOM 5615 N LYS L 145 41. 674 -27. 273 -25. ,810 1.00 41. 13 L N

ATOM 5616 CA LYS L 145 41.540 -27. 614 -24. ,393 1.00 41. 14 L C

ATOM 5618 CB LYS L 145 42. 322 -28. 893 -24. ,060 1.00 42. 55 L C

ATOM 5621 CG LYS L 145 42. 405 -29. 245 -22. ,553 1.00 45. 16 L C

ATOM 5624 CD LYS L 145 43. 705 -30. 017 -22. ,174 1.00 47. 77 L c

ATOM 5627 CE LYS L 145 44. 868 -29. 099 -21. ,699 1.00 49. 76 L c

ATOM 5630 NZ LYS L 145 45. 154 -29. 151 -20. ,227 1.00 50. 73 L N

ATOM 5634 C LYS L 145 42. 074 -26. 442 -23. ,585 1.00 38. 67 L C

ATOM 5635 O LYS L 145 43. 158 -25. 938 -23. ,868 1.00 37. 45 L 0

ATOM 5637 N VAL L 146 41. 320 -26. 028 -22. ,569 1.00 38. 37 L N

ATOM 5638 CA VAL L 146 41. 733 -24. 937 -21. ,688 1.00 36. 22 L c

ATOM 5640 CB VAL L 146 40. 886 -23. 662 -21.955 1.00 34. 98 L c

ATOM 5642 CGl VAL L 146 41. 399 -22. 501 -21. ,164 1.00 32. 51 L c

ATOM 5646 CG2 VAL L 146 40. 873 -23. 317 -23. ,453 1.00 31. 37 L c

ATOM 5650 C VAL L 146 41.616 -25. 376 -20. ,217 1.00 36. 22 L c

ATOM 5651 O VAL L 146 40. 511 -25. 518 -19. ,691 1.00 34. 63 L 0

ATOM 5653 N GLN L 147 42. 764 -25. 593 -19. ,567 1.00 36. 17 L N

ATOM 5654 CA GLN L 147 42. 817 -25. 995 -18. ,145 1.00 38. 72 L c

ATOM 5656 CB GLN L 147 43. 796 -27. 165 -17. ,933 1.00 44. 21 L c

ATOM 5659 CG GLN L 147 43. 146 -28. 563 -17. ,916 1.00 50. 68 L c

ATOM 5662 CD GLN L 147 42. 458 -28. 915 -16. ,592 1.00 56. 57 L c

ATOM 5663 OEl GLN L 147 42. 831 -28. 426 -15. ,510 1.00 57. 00 L 0

ATOM 5664 NE2 GLN L 147 41. 457 -29. 791 -16. ,676 1.00 57. 92 L N

ATOM 5667 C GLN L 147 43. 248 -24. 845 -17. ,241 1.00 36. 13 L c

ATOM 5668 0 GLN L 147 44. 185 -24. 116 -17. ,561 1.00 34. 51 L 0

ATOM 5670 N TRP L 148 42. 582 -24. 720 -16. ,099 1.00 34. 21 L N

ATOM 5671 CA TRP L 148 42. 949 -23. 730 -15. ,094 1.00 36. 62 L c

ATOM 5673 CB TRP L 148 41. 698 -23. 168 -14. ,416 1.00 33. 63 L c

ATOM 5676 CG TRP L 148 40. 901 -22. 236 -15. ,274 1.00 33. 25 L c

ATOM 5677 CDl TRP L 148 39. 770 -22. 535 -15. ,969 1.00 32. 47 L c

ATOM 5679 NEl TRP L 148 39. 315 -21.424 -16. ,629 1.00 32. 55 L N

ATOM 5681 CE2 TRP L 148 40. 157 -20. 374 -16. ,374 1.00 32. 76 L c

ATOM 5682 CD 2 TRP L 148 41. 165 -20. 846 -15. ,514 1.00 33. 28 L c

ATOM 5683 CE3 TRP L 148 42. 159 -19. 958 -15. ,093 1.00 31. 89 L c

ATOM 5685 CZ3 TRP L 148 42. 115 -18. 651 -15. ,533 1.00 31. 85 L c

ATOM 5687 CH2 TRP L 148 41. 095 -18. 206 -16. .377 1.00 32. 35 L c

ATOM 5689 CZ2 TRP L 148 40. 110 -19. 051 -16. ,813 1.00 32. 33 L c

ATOM 5691 C TRP L 148 43. 887 -24. 314 -14. ,030 1.00 38. 94 L c

ATOM 5692 0 TRP L 148 43. 809 -25. 504 -13. ,700 1.00 38. 01 L 0

ATOM 5694 N LYS L 149 44. 767 -23. 453 -13. ,509 1.00 41. 26 L N

ATOM 5695 CA LYS L 149 45. 681 -23. 780 -12, ,407 1.00 40. 46 L c

ATOM 5697 CB LYS L 149 47. 103 -24. 009 -12. ,930 1.00 42. 22 L c

ATOM 5700 CG LYS L 149 47. 225 -25. 082 -14, ,009 1.00 43. 51 L c

ATOM 5703 CD LYS L 149 48. 622 -25. 084 -14, ,622 1.00 44. 86 L c

ATOM 5706 CE LYS L 149 48. 707 -25. 981 -15. ,856 1.00 45. 55 L c cyno fD_Fab

ATOM 5709 NZ LYS L 149 48.584 -27. .430 -15. 504 1.00 47. 43 L N

ATOM 5713 C LYS L 149 45. 700 -22. ,630 -11. 395 1.00 38. 22 L C

ATOM 5714 O LYS L 149 45. 929 -21. ,483 -11. 761 1.00 35. 51 L 0

ATOM 5716 N VAL L 150 45. 447 -22. ,947 -10. 129 1.00 38. 52 L N

ATOM 5717 CA VAL L 150 45. 546 -21. ,976 -9. 034 1.00 39. 86 L C

ATOM 5719 CB VAL L 150 44. 176 -21. ,759 -8. 352 1.00 37. 38 L C

ATOM 5721 CGI VAL L 150 44. 297 -20. ,771 -7. 207 1.00 35. 32 L C

ATOM 5725 CG2 VAL L 150 43. 145 -21. ,280 -9. 381 1.00 36. 43 L C

ATOM 5729 C VAL L 150 46. 589 -22. ,470 -8. 019 1.00 40. 63 L c

ATOM 5730 O VAL L 150 46. 400 -23. ,505 -7. 372 1.00 39. 39 L 0

ATOM 5732 N ASP L 151 47. 688 -21. ,725 -7. 894 1.00 41. 61 L N

ATOM 5733 CA ASP L 151 48. 880 -22. ,175 -7. 163 1.00 41. 95 L C

ATOM 5735 CB ASP L 151 48. 589 -22. ,382 -5. 657 1.00 39. 46 L c

ATOM 5738 CG ASP L 151 48. 255 -21. ,084 -4. 930 1.00 39. 50 L c

ATOM 5739 ODl ASP L 151 48. 727 -20. ,012 -5. 365 1.00 39. 54 L 0

ATOM 5740 OD2 ASP L 151 47. 538 -21. 135 -3. 900 1.00 38. 04 L 0

ATOM 5741 C ASP L 151 49. 426 -23. ,458 -7. 807 1.00 42. 83 L c

ATOM 5742 O ASP L 151 49. 930 -24. 343 -7. 122 1.00 46. 78 L 0

ATOM 5744 N ASN L 152 49. 311 -23. ,547 -9. 131 1.00 43. 24 L N

ATOM 5745 CA ASN L 152 49. 712 -24. ,737 -9. 895 1.00 42. 26 L c

ATOM 5747 CB ASN L 152 51. 212 -25. ,027 -9. 695 1.00 42. 94 L c

ATOM 5750 CG ASN L 152 51. 840 -25. ,773 -10. 874 1.00 44. 44 L c

ATOM 5751 ODl ASN L 152 51.191 -26. ,044 -11. 885 1.00 42. 74 L 0

ATOM 5752 ND2 ASN L 152 53. 118 -26. ,110 -10. 738 1.00 45. 91 L N

ATOM 5755 C ASN L 152 48. 860 -25. ,992 -9. 603 1.00 40. 47 L c

ATOM 5756 O ASN L 152 49. 204 -27. 093 -10. 034 1.00 40. 28 L 0

ATOM 5758 N ALA L 153 47. 744 -25. ,817 -8. 893 1.00 38. 67 L N

ATOM 5759 CA ALA L 153 46. 798 -26. 902 -8. 617 1.00 39. 00 L c

ATOM 5761 CB ALA L 153 46. 160 -26. ,704 -7. 243 1.00 40. 10 L c

ATOM 5765 C ALA L 153 45. 715 -26. ,942 -9. 701 1.00 38. 97 L c

ATOM 5766 O ALA L 153 45. 034 -25. ,943 -9. 941 1.00 37. 63 L 0

ATOM 5768 N LEU L 154 45. 545 -28. ,092 -10. 346 1.00 38. 02 L N

ATOM 5769 CA LEU L 154 44. 566 -28. ,208 -11.427 1.00 39. 82 L c

ATOM 5771 CB LEU L 154 44. 717 -29. ,520 -12. 193 1.00 40. 00 L c

ATOM 5774 CG LEU L 154 45. 505 -29. ,353 -13. 483 1.00 42. 88 L c

ATOM 5776 CDl LEU L 154 47. 003 -29. ,325 -13. 191 1.00 43. 14 L c

ATOM 5780 CD2 LEU L 154 45. 124 -30. ,472 -14. 434 1.00 42. 40 L c

ATOM 5784 C LEU L 154 43. 132 -28. ,063 -10. 926 1.00 40. 15 L c

ATOM 5785 O LEU L 154 42. 778 -28. ,609 -9. 877 1.00 35. 98 L 0

ATOM 5787 N GLN L 155 42. 319 -27. ,343 -11. 707 1.00 38. 53 L N

ATOM 5788 CA GLN L 155 40. 970 -26. ,971 -11. 305 1.00 35. 70 L c

ATOM 5790 CB GLN L 155 40. 707 -25. ,498 -11. 627 1.00 32. 72 L c

ATOM 5793 CG GLN L 155 41. 586 -24. ,531 -10. 863 1.00 30. 98 L c

ATOM 5796 CD GLN L 155 41. 511 -24. ,772 -9. 378 1.00 28. 89 L c

ATOM 5797 OEl GLN L 155 42. 471 -25. ,240 -8. 765 1.00 23. 19 L 0

ATOM 5798 NE2 GLN L 155 40. 352 -24. ,499 -8. 796 1.00 27. ,15 L N

ATOM 5801 C GLN L 155 39. 959 -27. ,822 -12. 026 1.00 35. 34 L C

ATOM 5802 O GLN L 155 40. 192 -28. ,254 -13. 156 1.00 32. ,05 L 0

ATOM 5804 N SER L 156 38. 820 -28. ,041 -11. 375 1.00 37. 01 L N

ATOM 5805 CA SER L 156 37. 744 -28. ,824 -11. 975 1.00 38. 33 L C

ATOM 5807 CB SER L 156 38. 014 -30. ,316 -11. 759 1.00 40. 72 L c

ATOM 5810 OG SER L 156 37. 128 -31. ,116 -12. 513 1.00 41.57 L 0

ATOM 5812 C SER L 156 36. 384 -28. ,439 -11. 394 1.00 37. 32 L c

ATOM 5813 0 SER L 156 36. 248 -28. ,257 -10. 179 1.00 36. 49 L 0

ATOM 5815 N GLY L 157 35. 395 -28. ,299 -12. 273 1.00 34. ,50 L N

ATOM 5816 CA GLY L 157 34. 009 -28. ,042 -11. 874 1.00 35. 89 L c

ATOM 5819 C GLY L 157 33. 659 -26. ,592 -11. 574 1.00 36. ,75 L c

ATOM 5820 0 GLY L 157 32. 543 -26. ,309 -11. 131 1.00 35. 23 L 0

ATOM 5822 N ASN L 158 34. 596 -25. ,675 -11. 828 1.00 35. 34 L N

ATOM 5823 CA ASN L 158 34. 441 -24. ,255 -11. 455 1.00 33. 35 L c

ATOM 5825 CB ASN L 158 35. 394 -23. ,903 -10. 288 1.00 32. 43 L c

ATOM 5828 CG ASN L 158 36. 873 -24. .208 -10. 603 1.00 32. ,37 L c

ATOM 5829 ODl ASN L 158 37. 203 -24. .796 -11. 638 1.00 33. ,66 L 0

ATOM 5830 ND2 ASN L 158 37. 759 -23. ,788 -9. 713 1.00 30. ,38 L N

ATOM 5833 C ASN L 158 34. 637 -23. ,276 -12. 626 1.00 30. ,43 L c

ATOM 5834 0 ASN L 158 34. 738 -22. ,063 -12. 423 1.00 23. ,30 L 0

ATOM 5836 N SER L 159 34. 661 -23. ,802 -13. 849 1.00 32. 33 L N

ATOM 5837 CA SER L 159 34. 948 -22. ,993 -15. 014 1.00 30. ,78 L c cyno fD._Fab

ATOM 5839 CB SER L 159 36.415 -23. ,189 -15. ,428 1.00 32. 00 L C

ATOM 5842 OG SER L 159 36.570 -24. ,162 -16. ,452 1.00 32. 67 L 0

ATOM 5844 C SER L 159 33.981 -23. ,350 -16. ,145 1.00 30. 89 L C

ATOM 5845 O SER L 159 33.678 -24. ,525 -16. ,345 1.00 30. 86 L 0

ATOM 5847 N GLN L 160 33.484 -22. ,334 -16. ,856 1.00 28. 29 L N

ATOM 5848 CA GLN L 160 32.637 -22. ,538 -18. ,032 1.00 28. 38 L c

ATOM 5850 CB GLN L 160 31.265 -21. ,921 -17. ,807 1.00 26. 44 L c

ATOM 5853 CG GLN L 160 30.524 -22. ,550 -16. ,671 1.00 25. 96 L c

ATOM 5856 CD GLN L 160 29.119 -22. ,063 -16. ,572 1.00 25. 84 L c

ATOM 5857 OEl GLN L 160 28.875 -20. ,926 -16. ,181 1.00 30. 50 L 0

ATOM 5858 NE2 GLN L 160 28.173 -22. ,919 -16.917 1.00 26. 98 L N

ATOM 5861 C GLN L 160 33.245 -21. ,941 -19. ,293 1.00 29. 62 L c

ATOM 5862 O GLN L 160 33.834 -20. .869 -19. ,249 1.00 28. 77 L 0

ATOM 5864 N GLU L 161 33.076 -22. ,636 -20. ,420 1.00 30. 95 L N

ATOM 5865 CA GLU L 161 33.524 -22. ,138 -21.711 1.00 33. 83 L C

ATOM 5867 CB GLU L 161 34.276 -23. ,222 -22. ,486 1.00 38. 76 L c

ATOM 5870 CG GLU L 161 35.494 -23. ,761 -21. ,770 1.00 39. 08 L C

ATOM 5873 CD GLU L 161 36.402 -24. ,558 -22. ,679 1.00 42. 52 L C

ATOM 5874 OEl GLU L 161 35.974 -24. ,934 -23. 798 1.00 44. 52 L 0

ATOM 5875 OE2 GLU L 161 37.554 -24. ,816 -22. 268 1.00 47. 30 L 0

ATOM 5876 C GLU L 161 32.365 -21. ,637 -22. ,570 1.00 34. 87 L c

ATOM 5877 O GLU L 161 31.201 -21. ,991 -22. ,350 1.00 33. 52 L 0

ATOM 5879 N SER L 162 32.719 -20. ,813 -23. ,552 1.00 33. 74 L N

ATOM 5880 CA SER L 162 31.801 -20. 322 -24. 572 1.00 32. 35 L c

ATOM 5882 CB SER L 162 31.182 -18. ,999 -24. ,128 1.00 35. 98 L c

ATOM 5885 OG SER L 162 30.182 -18. 557 -25. 020 1.00 35. 55 L 0

ATOM 5887 C SER L 162 32.625 -20. ,124 -25. 834 1.00 32. 54 L c

ATOM 5888 O SER L 162 33.729 -19. ,604 -25. 765 1.00 30. 03 L 0

ATOM 5890 N VAL L 163 32.122 -20. ,589 -26. 974 1.00 33. 10 L N

ATOM 5891 CA VAL L 163 32.826 -20. ,427 -28. ,241 1.00 33. 91 L c

ATOM 5893 CB VAL L 163 33.243 -21. ,790 -28. ,850 1.00 32. 64 L c

ATOM 5895 CGI VAL L 163 34.207 -21. ,596 -30. 029 1.00 31. 57 L c

ATOM 5899 CG2 VAL L 163 33.892 -22. 650 -27. ,798 1.00 34. 29 L c

ATOM 5903 C VAL L 163 31.934 -19. ,655 -29. 208 1.00 34. 43 L c

ATOM 5904 O VAL L 163 30.721 -19. ,847 -29. ,229 1.00 31. 52 L 0

ATOM 5906 N THR L 164 32.538 -18. ,763 -29. 990 1.00 36. 47 L N

ATOM 5907 CA THR L 164 31.804 -18. ,032 -31. 013 1.00 35. 31 L c

ATOM 5909 CB THR L 164 32.556 -16. ,767 -31. ,517 1.00 33. 28 L c

ATOM 5911 OG1 THR L 164 33.743 -17. ,142 -32. ,221 1.00 30. 68 L 0

ATOM 5913 CG2 THR L 164 32.904 -15. ,847 -30. ,368 1.00 28. 73 L c

ATOM 5917 C THR L 164 31.514 -18. ,948 -32. ,197 1.00 33. 32 L c

ATOM 5918 O THR L 164 32.104 -20.023 -32. ,334 1.00 32. 16 L 0

ATOM 5920 N GLU L 165 30.575 -18. ,522 -33. ,037 1.00 34. 83 L N

ATOM 5921 CA GLU L 165 30.347 -19. ,193 -34. ,311 1.00 34. 72 L c

ATOM 5923 CB GLU L 165 28.978 -18. ,841 -34. ,898 1.00 37. 44 L c

ATOM 5926 CG GLU L 165 27.812 -19. ,471 -34. ,120 1.00 43. 21 L c

ATOM 5929 CD GLU L 165 27.887 -21. ,000 -34. ,073 1.00 51. 03 L c

ATOM 5930 OEl GLU L 165 28.070 -21. ,633 -35. ,146 1.00 51. ,16 L 0

ATOM 5931 OE2 GLU L 165 27.771 -21. ,567 -32. ,957 1.00 54. 23 L 0

ATOM 5932 C GLU L 165 31.489 -18. ,822 -35. ,236 1.00 29. 86 L c

ATOM 5933 O GLU L 165 32.244 -17. ,900 -34. ,955 1.00 29. 39 L 0

ATOM 5935 N GLN L 166 31.653 -19. ,563 -36. ,319 1.00 31. 36 L N

ATOM 5936 CA GLN L 166 32.793 -19. ,319 -37. ,186 1.00 30. 42 L c

ATOM 5938 CB GLN L 166 32.889 -20. ,405 -38. ,243 1.00 28. 77 L c

ATOM 5941 CG GLN L 166 34.140 -20. ,344 -39. ,035 1.00 28. 12 L c

ATOM 5944 CD GLN L 166 34.286 -21.516 -39. ,981 1.00 26. ,48 L c

ATOM 5945 OEl GLN L 166 33.306 -22. ,100 -40. ,431 1.00 24. ,75 L 0

ATOM 5946 NE2 GLN L 166 35.522 -21. ,871 -40. ,270 1.00 25. ,55 L N

ATOM 5949 C GLN L 166 32.698 -17. ,926 -37, ,820 1.00 30. ,92 L c

ATOM 5950 O GLN L 166 31.624 -17. ,508 -38. ,248 1.00 34. ,91 L 0

ATOM 5952 N ASP L 167 33.820 -17. ,215 -37. ,867 1.00 32. ,12 L N

ATOM 5953 CA ASP L 167 33.832 -15. ,817 -38. ,298 1.00 33. ,08 L c

ATOM 5955 CB ASP L 167 35.125 -15. ,123 -37. ,833 1.00 34. ,36 L c

ATOM 5958 CG ASP L 167 35.176 -13. ,635 -38. ,204 1.00 34. 47 L c

ATOM 5959 ODl ASP L 167 34.544 -12. .823 -37. ,502 1.00 34. ,75 L 0

ATOM 5960 OD2 ASP L 167 35.865 -13. .281 -39. ,191 1.00 33. ,86 L 0

ATOM 5961 C ASP L 167 33.686 -15. .720 -39. ,808 1.00 31.48 L c

ATOM 5962 O ASP L 167 34.312 -16. ,470 -40. ,549 1.00 34. ,77 L 0 cyno fD_Fab

ATOM 5964 N SER L 168 32. ,865 -14. 781 -40. ,264 1.00 32. 07 L N

ATOM 5965 CA SER L 168 32. .556 -14. ,651 -41. ,683 1.00 33. ,45 L C

ATOM 5967 CB SER L 168 31. .249 -13. ,886 -41. ,855 1.00 34. ,85 L C

ATOM 5970 OG SER L 168 31.439 -12. 532 -41. .521 1.00 40. 40 L 0

ATOM 5972 C SER L 168 33. .658 -13. 991 -42. ,527 1.00 34. 80 L C

ATOM 5973 O SER L 168 33. ,551 -13. 963 -43. ,755 1.00 39. 95 L 0

ATOM 5975 N LYS L 169 34. .707 -13. 468 -41.891 1.00 36. 87 L N

ATOM 5976 CA LYS L 169 35. ,856 -12. 897 -42. ,619 1.00 38. 46 L c

ATOM 5978 CB LYS L 169 36. ,268 -11. 537 -42. ,051 1.00 42. 53 L c

ATOM 5981 CG LYS L 169 35. ,455 -10. 363 -42. ,579 1.00 48. 26 L c

ATOM 5984 CD LYS L 169 35. ,925 -9. ,016 -42. ,003 1.00 49. 20 L c

ATOM 5987 CE LYS L 169 37. ,414 -8. ,710 -42. ,293 1.00 53. 98 L c

ATOM 5990 NZ LYS L 169 37. ,830 -8. 937 -43. ,714 1.00 54. 50 L N

ATOM 5994 C LYS L 169 37. ,066 -13. 818 -42. ,610 1.00 34. 45 L c

ATOM 5995 0 LYS L 169 37. ,632 -14. 082 -43. ,667 1.00 35. 19 L 0

ATOM 5997 N ASP L 170 37. ,469 -14. 281 -41.423 1.00 33. 51 L N

ATOM 5998 CA ASP L 170 38. ,679 -15. 119 -41. ,274 1.00 32. 06 L C

ATOM 6000 CB ASP L 170 39. ,698 -14. ,524 -40. ,258 1.00 35. 84 L C

ATOM 6003 CG ASP L 170 39. ,183 -14. 462 -38. ,806 1.00 37. 71 L C

ATOM 6004 ODl ASP L 170 38. ,166 -15. 083 -38. ,446 1.00 38. 90 L 0

ATOM 6005 002 ASP L 170 39. 828 -13. 763 -38. ,000 1.00 43. 09 L 0

ATOM 6006 C ASP L 170 38. 406 -16. 594 -40. ,987 1.00 29. 88 L C

ATOM 6007 0 ASP L 170 39. 337 -17. 378 -40. ,902 1.00 32. 35 L 0

ATOM 6009 N SER L 171 37. ,136 -16. 970 -40. ,861 1.00 26. 94 L N

ATOM 6010 CA SER L 171 36. ,739 -18. 377 -40. ,720 1.00 27. 22 L c

ATOM 6012 CB SER L 171 37. ,053 -19. 163 -41. ,999 1.00 23. 36 L c

ATOM 6015 OG SER L 171 36. ,436 -18. 565 -43. ,142 1.00 24. 46 L 0

ATOM 6017 C SER L 171 37. 333 -19. 050 -39. ,477 1.00 26. 73 L c

ATOM 6018 0 SER L 171 37. ,538 -20. 264 -39. ,462 1.00 26. 39 L 0

ATOM 6020 N THR L 172 37. ,575 -18. 250 -38. ,434 1.00 27. 07 L N

ATOM 6021 CA THR L 172 38. 126 -18. 734 -37. 169 1.00 22. 43 L c

ATOM 6023 CB THR L 172 39. 376 -17. 915 -36. ,694 1.00 24. 57 L c

ATOM 6025 OGl THR L 172 39. 000 -16. 566 -36. ,371 1.00 30. 12 L 0

ATOM 6027 CG2 THR L 172 40. ,496 -17. 926 -37. ,732 1.00 25. 53 L c

ATOM 6031 C THR L 172 37. ,078 -18. 673 -36. ,072 1.00 23. 37 L c

ATOM 6032 0 THR L 172 35. ,972 -18. 167 -36. ,290 1.00 24. 31 L 0

ATOM 6034 N TYR L 173 37. ,448 -19. 214 -34. ,907 1.00 24. 61 L N

ATOM 6035 CA TYR L 173 36. ,643 -19. 212 -33. ,694 1.00 23. 41 L c

ATOM 6037 CB TYR L 173 36. ,412 -20. 643 -33. ,207 1.00 29. 32 L c

ATOM 6040 CG TYR L 173 35. ,761 -21. 536 -34. ,231 1.00 31. 13 L c

ATOM 6041 CDl TYR L 173 34. ,384 -21. 680 -34. ,268 1.00 31.32 L c

ATOM 6043 CEl TYR L 173 33. ,779 -22. ,476 -35. ,211 1.00 30. 88 L c

ATOM 6045 CZ TYR L 173 34. ,559 -23. ,141 -36. ,119 1.00 30. 16 L c

ATOM 6046 OH TYR L 173 33. ,965 -23. 930 -37. ,058 1.00 34. 02 L 0

ATOM 6048 CE2 TYR L 173 35. ,935 -23. ,012 -36. ,103 1.00 30. 58 L c

ATOM 6050 CD2 TYR L 173 36. ,521 -22. ,217 -35. ,169 1.00 28. 39 L c

ATOM 6052 C TYR L 173 37. ,370 -18. 462 -32. ,603 1.00 23. 24 L c

ATOM 6053 0 TYR L 173 38. ,599 -18. ,321 -32. ,641 1.00 19. 59 L 0

ATOM 6055 N SER L 174 36. ,614 -17. ,995 -31. ,615 1.00 24. 95 L N

ATOM 6056 CA SE L 174 37. ,192 -17. ,497 -30. ,378 1.00 26. 07 L c

ATOM 6058 CB SER L 174 37. ,086 -15. ,976 -30. ,288 1.00 27. 75 L c

ATOM 6061 OG SER L 174 37. ,833 -15. ,374 -31. ,331 1.00 31.20 L 0

ATOM 6063 C SER L 174 36. ,483 -18. ,175 -29. ,218 1.00 29. 37 L c

ATOM 6064 0 SER L 174 35. 407 -18. ,719 -29. ,389 1.00 29. 88 L 0

ATOM 6066 N LEU L 175 37. 098 -18. ,147 -28. ,040 1.00 30. 68 L N

ATOM 6067 CA LEU L 175 36. 588 -18. ,875 -26. ,880 1.00 26. 18 L c

ATOM 6069 CB LEU L 175 37. ,238 -20. ,269 -26. ,810 1.00 27. 28 L c

ATOM 6072 CG LEU L 175 36. ,899 -21. ,220 -25, .655 1.00 27. 53 L c

ATOM 6074 CDl LEU L 175 37. ,113 -22. ,653 -26. ,077 1.00 22. 57 L c

ATOM 6078 CD2 LEU L 175 37. ,715 -20. ,931 -24. .393 1.00 25. 16 L c

ATOM 6082 C LEU L 175 36. ,910 -18. ,082 -25. ,640 1.00 24. 86 L c

ATOM 6083 0 LEU L 175 38. ,029 -17. ,597 -25. ,492 1.00 25. 64 L 0

ATOM 6085 N SER L 176 35. ,923 -17. ,916 -24. ,765 1.00 26. 41 L N

ATOM 6086 CA SER L 176 36. ,178 -17. ,441 -23. ,416 1.00 28. 55 L c

ATOM 6088 CB SER L 176 35. ,179 -16. ,355 -23. ,010 1.00 31. 26 L c

ATOM 6091 OG SER L 176 33. ,862 -16. ,863 -22, .916 1.00 32. 89 L 0

ATOM 6093 C SER L 176 36. ,072 -18. ,639 -22, ,482 1.00 30. ,96 L c

ATOM 6094 0 SER L 176 35. ,328 -19. 573 -22, ,756 1.00 35. 23 L 0 cyno fD_Fab

ATOM 6096 N SER L 177 36. .840 -18. ,619 -21. ,399 1. 00 34. ,04 L N

ATOM 6097 CA SER L 177 36. .668 -19. 558 -20. ,293 1. 00 30. 27 L C

ATOM 6099 CB SER L 177 37. ,781 -20. 594 -20. 292 1. 00 31. 08 L C

ATOM 6102 OG SER L 177 37. ,770 -21.294 -19. ,070 1. 00 27. 93 L 0

ATOM 6104 C SER L 177 36. ,676 -18. 782 -18. ,991 1. 00 31. 32 L C

ATOM 6105 O SER L 177 37. ,599 -18. 023 -18. ,741 1. 00 32. 27 L 0

ATOM 6107 N THR L 178 35. ,644 -18. 969 -18. 169 1. 00 31. 30 L N

ATOM 6108 CA THR L 178 35. ,489 -18. 203 -16. ,943 1. 00 30. 24 L C

ATOM 6110 CB THR L 178 34. ,186 -17. 384 -16. ,956 1. 00 32. 10 L C

ATOM 6112 OGl THR L 178 34. ,071 -16. 684 -18. ,205 1. 00 32. 15 L 0

ATOM 6114 CG2 THR L 178 34. ,175 -16. 393 -15. ,806 1. 00 27. 85 L c

ATOM 6118 C THR L 178 35. ,535 -19. 063 -15. 679 1. 00 28. 58 L c

ATOM 6119 O THR L 178 34. ,609 -19. 821 -15. 383 1. 00 23. 32 L 0

ATOM 6121 N LEU L 179 36. ,631 -18. 905 -14. 941 1. 00 28. 79 L N

ATOM 6122 CA LEU L 179 36. ,848 -19. 529 -13. 637 1. 00 28. 35 L C

ATOM 6124 CB LEU L 179 38. ,354 -19. 644 -13. ,378 1. 00 27. 48 L C

ATOM 6127 CG LEU L 179 38. 826 -20. 264 -12. 068 1. 00 27. 66 L C

ATOM 6129 CDl LEU L 179 38. ,584 -21. 754 -12. 130 1. 00 29. 06 L C

ATOM 6133 CD2 LEU L 179 40. ,292 -19. 958 -11. 834 1. 00 27. 43 L c

ATOM 6137 C LEU L 179 36. 229 -18. 645 -12. ,570 1. 00 26. 76 L c

ATOM 6138 O LEU L 179 36. ,588 -17. 478 -12. 469 1. 00 24. 87 L 0

ATOM 6140 N THR L 180 35. ,312 -19. 202 -11.779 1. 00 30. 35 L N

ATOM 6141 CA THR L 180 34. ,630 -18. 455 -10. 727 1. 00 33. 54 L c

ATOM 6143 CB THR L 180 33. ,097 -18. 483 -10. 921 1. 00 36. 42 L c

ATOM 6145 OGl THR L 180 32. ,758 -17. 860 -12. 168 1. 00 40. 29 L 0

ATOM 6147 CG2 THR L 180 32. ,378 -17. 742 -9. 773 1. 00 36. 08 L c

ATOM 6151 C THR L 180 34. ,967 -19. 006 -9. ,335 1. 00 37. 60 L c

ATOM 6152 O THR L 180 34. ,836 -20. 207 -9. ,090 1. 00 40. 96 L 0

ATOM 6154 N LEU L 181 35. ,404 -18. 112 -8. ,442 1. 00 38. 42 L N

ATOM 6155 CA LEU L 181 35. ,636 -18. 419 -7. ,027 1. 00 35. 46 L c

ATOM 6157 CB LEU L 181 37. 134 -18. 386 -6. 688 1. 00 34. 84 L c

ATOM 6160 CG LEU L 181 38. ,144 -19. 157 -7. 545 1. 00 34. 65 L c

ATOM 6162 CDl LEU L 181 38. 389 -18. 453 -8. ,869 1. 00 35. 54 L c

ATOM 6166 CD2 LEU L 181 39. 449 -19. 325 -6. 793 1. 00 32. 17 L c

ATOM 6170 C LEU L 181 34. 931 -17. 384 -6. 162 1. 00 35. 81 L c

ATOM 6171 O LEU L 181 34. ,535 -16. 325 -6. 642 1. 00 32. 20 L 0

ATOM 6173 N SER L 182 34. 789 -17. 691 -4. 875 1. 00 38. 48 L N

ATOM 6174 CA SER L 182 34. 430 -16. 677 -3. 889 1. 00 40. 00 L c

ATOM 6176 CB SER L 182 34. 056 -17. 314 -2. 550 1. 00 39. 97 L c

ATOM 6179 OG SER L 182 35. 154 -18. 044 -2. 028 1. 00 41.68 L 0

ATOM 6181 C SER L 182 35. ,636 -15. 765 -3. ,701 1. 00 39. 71 L c

ATOM 6182 O SER L 182 36. ,776 -16. 174 -3. ,955 1. 00 38. 11 L 0

ATOM 6184 N LYS L 183 35. ,376 -14. 529 -3. ,283 1. 00 40. 16 L N

ATOM 6185 CA LYS L 183 36. ,433 -13. 609 -2. ,853 1. 00 41.56 L c

ATOM 6187 CB LYS L 183 35. 820 -12. 342 -2. ,240 1. 00 41. 26 L c

ATOM 6190 CG LYS L 183 36. ,828 -11. 287 -1. ,743 1. 00 41.42 L c

ATOM 6193 CD LYS L 183 36. ,135 -10. 198 -0. 922 1. 00 40. 80 L c

ATOM 6196 CE LYS L 183 37. 086 -9. 062 -0. ,531 1. 00 40. 78 L c

ATOM 6199 NZ LYS L 183 37. ,995 -9. 438 0. ,581 1. 00 35. 82 L N

ATOM 6203 C LYS L 183 37. 324 -14. 300 -1. ,823 1. 00 42. 13 L c

ATOM 6204 O LYS L 183 38. ,554 -14. 317 -1. ,964 1. 00 41. 13 L 0

ATOM 6206 N ALA L 184 36. ,687 -14. 873 -0. 798 1. 00 42. 16 L N

ATOM 6207 CA ALA L 184 37. 391 -15. 559 0. 287 1. 00 42. 49 L c

ATOM 6209 CB ALA L 184 36. ,400 -16. 292 1. ,190 1. 00 42. ,47 L c

ATOM 6213 C ALA L 184 38. ,450 -16. 524 -0. ,243 1. 00 42. ,76 L c

ATOM 6214 O ALA L 184 39. ,619 -16. 436 0. ,140 1. 00 41. 63 L 0

ATOM 6216 N ASP L 185 38. ,052 -17. 426 -1. ,141 1. 00 46. ,13 L N

ATOM 6217 CA ASP L 185 38. ,991 -18. 415 -1. ,690 1. 00 44. 00 L c

ATOM 6219 CB ASP L 185 38. 243 -19. 597 -2. ,337 1. 00 47. 80 L c

ATOM 6222 CG ASP L 185 39. ,135 -20. 840 -2. ,534 1. 00 50. ,72 L c

ATOM 6223 ODl ASP L 185 40. ,083 -21. 066 -1. ,739 1. 00 52. ,27 L 0

ATOM 6224 OD2 ASP L 185 38. ,872 -21. 609 -3. ,490 1. 00 53. 80 L 0

ATOM 6225 C ASP L 185 39. ,972 -17. 768 -2. ,679 1. 00 40. 68 L c

ATOM 6226 O ASP L 185 41. ,135 -18. 169 -2. ,749 1. 00 36. 93 L 0

ATOM 6228 N TYR L 186 39. ,512 -16. 755 -3. ,416 1. 00 40. 48 L N

ATOM 6229 CA TYR L 186 40. 354 -16. 069 -4. ,410 1. 00 40. 75 L c

ATOM 6231 CB TYR L 186 39. ,546 -15. Oil -5. ,196 1. 00 37. 27 L c

ATOM 6234 CG TYR L 186 40. ,395 -14. 161 -6. ,133 1. 00 37. ,30 L c cyno fD_.Fab

ATOM 6235 CDl TYR L 186 41. 002 -14. 718 -7. 252 1.00 36. ,31 L C

ATOM 6237 CEl TYR L 186 41. 788 -13. 951 -8. 108 1.00 36. 20 L C

ATOM 6239 CZ TYR L 186 41. 973 -12. 613 -7. 850 1.00 35. ,59 L C

ATOM 6240 OH TYR L 186 42. 751 -11. 861 -8. ,693 1.00 35. ,44 L 0

ATOM 6242 CE2 TYR L 186 41. 385 -12. 028 -6. ,744 1.00 36. ,61 L C

ATOM 6244 CD2 TYR L 186 40. 599 -12. 803 -5. ,891 1.00 36. ,95 L C

ATOM 6246 C TYR L 186 41. 579 -15. 429 -3. ,747 1.00 38. ,71 L c

ATOM 6247 O TYR L 186 42. 687 -15. 494 -4. ,285 1.00 32. ,86 L 0

ATOM 6249 N GLU L 187 41. 362 -14. 829 -2. 576 1.00 40. ,69 L N

ATOM 6250 CA GLU L 187 42. 432 -14. 189 -1. 795 1.00 42. 64 L c

ATOM 6252 CB GLU L 187 41. 837 -13. 153 -0. 835 1.00 43. 11 L c

ATOM 6255 CG GLU L 187 41. 400 -11. 881 -1. ,538 1.00 43. ,81 L c

ATOM 6258 CD GLU L 187 40. 524 -10. 995 -0. ,685 1.00 43. ,62 L c

ATOM 6259 OEl GLU L 187 40. 095 -11. 426 0. ,409 1.00 41. ,82 L 0

ATOM 6260 OE2 GLU L 187 40. 253 -9. 860 -1. 127 1.00 45. ,57 L 0

ATOM 6261 C GLU L 187 43. 348 -15. 146 -1. 005 1.00 43. ,40 L c

ATOM 6262 O GLU L 187 44. 389 -14. 717 -0. 499 1.00 44. 40 L 0

ATOM 6264 N LYS L 188 42. 974 -16. 421 -0. 894 1.00 41. ,06 L N

ATOM 6265 CA LYS L 188 43. 838 -17. 414 -0. 242 1.00 40. 98 L c

ATOM 6267 CB LYS L 188 43. 008 -18. 590 0. 310 1.00 43. 40 L c

ATOM 6270 CG LYS L 188 42. 236 -18. 304 1. 621 1.00 45. ,68 L c

ATOM 6273 CD LYS L 188 43. 108 -17. 749 2. ,787 1.00 46. ,49 L c

ATOM 6276 CE LYS L 188 44. 301 -18. 652 3. ,151 1.00 45. 70 L c

ATOM 6279 NZ LYS L 188 45. 100 -18. 104 4. 286 1.00 45. 08 L N

ATOM 6283 C LYS L 188 44. 971 -17. 945 -1. 142 1.00 40. 44 L c

ATOM 6284 O LYS L 188 45. 934 -18. 534 -0. 632 1.00 38. ,51 L 0

ATOM 6286 N HIS L 189 44. 865 -17. 732 -2. 458 1.00 39. 12 L N

ATOM 6287 CA HIS L 189 45. 828 -18. 281 -3. 433 1.00 37. 96 L c

ATOM 6289 CB HIS L 189 45. 114 -19. 328 -4. 301 1.00 34. 01 L c

ATOM 6292 CG HIS L 189 44. 418 -20. 389 -3. ,494 1.00 34. ,80 L c

ATOM 6293 NDl HIS L 189 45. 099 -21. 355 -2. ,780 1.00 34. ,75 L N

ATOM 6295 CEl HIS L 189 44. 231 -22. 129 -2. ,150 1.00 35. ,27 L c

ATOM 6297 NE2 HIS L 189 43. 013 -21. 697 -2. ,421 1.00 35. ,24 L N

ATOM 6299 CD2 HIS L 189 43. 102 -20. 608 -3. 256 1.00 34. 22 L C

ATOM 6301 C HIS L 189 46. 529 -17. 167 -4. 256 1.00 36. ,94 L c

ATOM 6302 O HIS L 189 46. 068 -16. 028 -4. 267 1.00 34. 07 L 0

ATOM 6304 N LYS L 190 47. 640 -17. 499 -4. 924 1.00 39. 11 L N

ATOM 6305 CA LYS L 190 48. 585 -16. 494 -5. ,471 1.00 39. ,09 L c

ATOM 6307 CB LYS L 190 49. 990 -16. 783 -4. ,928 1.00 42. ,89 L c

ATOM 6310 CG LYS L 190 51. 143 -15. 941 -5. ,511 1.00 42. ,98 L C

ATOM 6313 CD LYS L 190 52. 479 -16. 360 -4. ,867 1.00 44. ,42 L c

ATOM 6316 CE LYS L 190 53. 637 -15. 425 -5. ,226 1.00 45. ,17 L c

ATOM 6319 NZ LYS L 190 54. 795 -15. 581 -4. 288 1.00 43. ,96 L N

ATOM 6323 C LYS L 190 48. 651 -16. 400 -7. ,005 1.00 38. ,45 L c

ATOM 6324 0 LYS L 190 48. 343 -15. 346 -7. ,574 1.00 36. ,16 L 0

ATOM 6326 N VAL L 191 49. 097 -17. 475 -7. ,660 1.00 35. ,28 L N

ATOM 6327 CA VAL L 191 49. 243 -17. 491 -9. ,125 1.00 37. ,14 L c

ATOM 6329 CB VAL L 191 50. 474 -18. 311 -9. ,583 1.00 38. ,23 L c

ATOM 6331 CGl VAL L 191 50. 602 -18. 280 -11. ,106 1.00 37. ,39 L c

ATOM 6335 CG2 VAL L 191 51. 747 -17. 779 -8. 929 1.00 40. ,15 L c

ATOM 6339 C VAL L 191 47. 996 -18. 055 -9. 813 1.00 34. ,68 L c

ATOM 6340 O VAL L 191 47. 496 -19. 121 -9. ,448 1.00 32. ,06 L 0

ATOM 6342 N TYR L 192 47. 504 -17. 328 -10. ,812 1.00 36. ,70 L N

ATOM 6343 CA TYR L 192 46. 369 -17. 773 -11. 624 1.00 35. ,58 L c

ATOM 6345 CB TYR L 192 45. 210 -16. 788 -11. ,491 1.00 32. ,47 L c

ATOM 6348 CG TYR L 192 44. 577 -16. 849 -10. ,121 1.00 31. ,96 L c

ATOM 6349 CDl TYR L 192 43. 384 -17. 536 -9. ,915 1.00 32. .83 L c

ATOM 6351 CEl TYR L 192 42. 809 -17. 614 -8. ,663 1.00 31. ,55 L c

ATOM 6353 CZ TYR L 192 43. 435 -17. 010 -7. ,591 1.00 32. ,15 L c

ATOM 6354 OH TYR L 192 42. 866 -17. 085 -6. 346 1.00 31.08 L 0

ATOM 6356 CE2 TYR L 192 44. 623 -16. 333 -7. ,768 1.00 31. ,22 L c

ATOM 6358 CD2 TYR L 192 45. 189 -16. 262 -9. 029 1.00 30. 85 L c

ATOM 6360 C TYR L 192 46. 802 -17. 945 -13. ,078 1.00 34. ,78 L c

ATOM 6361 O TYR L 192 47. 371 -17. 041 -13. ,675 1.00 33. 68 L 0

ATOM 6363 N ALA L 193 46. 539 -19. 124 -13. ,631 1.00 36. ,13 L N

ATOM 6364 CA ALA L 193 47. 005 -19. 476 -14. ,966 1.00 37. ,57 L c

ATOM 6366 CB ALA L 193 48. 306 -20. 260 -14. ,868 1.00 36. .55 L c

ATOM 6370 C ALA L 193 45. 964 -20. 292 -15. 722 1.00 35. ,68 L c cyno fD_Fab

ATOM 6371 O ALA L 193 45 302 -21. 158 -15 155 1.00 31 77 L 0

ATOM 6373 N CYS L 194 45 822 -20. 006 -17 008 1.00 40 77 L N

ATOM 6374 CA CYS L 194 45 073 -20. 886 -17 903 1.00 41 93 L C

ATOM 6376 CB CYS L 194 43 895 -20. 160 -18 576 1.00 43 71 L C

ATOM 6379 SG CYS L 194 44 341 -18. 811 -19 684 1.00 47 55 L s

ATOM 6381 C CYS L 194 46 050 -21. 457 -18 921 1.00 40 68 L C

ATOM 6382 O CYS L 194 46 825 -20. 717 -19 531 1.00 41 65 L 0

ATOM 6384 N GLU L 195 46 042 -22. 779 -19 065 1.00 39 22 L N

ATOM 6385 CA GLU L 195 46 923 -23. 434 -20 013 1.00 43 03 L c

ATOM 6387 CB GLU L 195 47 739 -24. 553 -19 352 1.00 45 41 L c

ATOM 6390 CG GLU L 195 47 064 -25. 914 -19 205 1.00 49 49 L c

ATOM 6393 CD GLU L 195 48 070 -27. 050 -19 275 1.00 50 76 L c

ATOM 6394 OEl GLU L 195 48 747 -27. 166 -20 321 1.00 52 44 L 0

ATOM 6395 OE2 GLU L 195 48 185 -27. 816 -18 290 1.00 55 09 L 0

ATOM 6396 C GLU L 195 46 096 -23. 912 -21 201 1.00 38 74 L c

ATOM 6397 O GLU L 195 45 054 -24. 546 -21 040 1.00 36 74 L 0

ATOM 6399 N VAL L 196 46 558 -23. 558 -22 389 1.00 37 23 L N

ATOM 6400 CA VAL L 196 45 799 -23. 752 -23 606 1.00 38 19 L c

ATOM 6402 CB VAL L 196 45 556 -22. 407 -24 343 1.00 36 91 L c

ATOM 6404 CGI VAL L 196 44 877 -22. 616 -25 697 1.00 34 72 L c

ATOM 6408 CG2 VAL L 196 44 736 -21.471 -23 462 1.00 34. 22 L c

ATOM 6412 C VAL L 196 46 607 -24. 670 -24 472 1.00 39. 34 L c

ATOM 6413 O VAL L 196 47 793 -24. 431 -24 680 1.00 38 45 L 0

ATOM 6415 N THR L 197 45 958 -25. 730 -24 950 1.00 41 60 L N

ATOM 6416 CA THR L 197 46 544 -26. 652 -25 908 1.00 41.60 L c

ATOM 6418 CB THR L 197 46 775 -28. 066 -25 293 1.00 44 28 L c

ATOM 6420 OGl THR L 197 46 988 -29. 021 -26 338 1.00 46 04 L 0

ATOM 6422 CG2 THR L 197 45 597 -28. 504 -24 479 1.00 42 28 L c

ATOM 6426 C THR L 197 45 644 -26. 696 -27 145 1.00 39 74 L c

ATOM 6427 O THR L 197 44 416 -26. 753 -27 046 1.00 40 14 L 0

ATOM 6429 N HIS L 198 46 281 -26. 626 -28 307 1.00 37. 75 L N

ATOM 6430 CA HIS L 198 45 597 -26. 526 -29 582 1.00 39. 95 L c

ATOM 6432 CB HIS L 198 45 162 -25. 065 -29 828 1.00 36. 41 L c

ATOM 6435 CG HIS L 198 44 363 -24. 870 -31 082 1.00 33 78 L c

ATOM 6436 NDl HIS L 198 44 942 -24. 569 -32 296 1.00 31 61 L N

ATOM 6438 CEl HIS L 198 44 003 -24. 464 -33 218 1.00 27 93 L c

ATOM 6440 NE2 HIS L 198 42 834 -24. 693 -32 648 1.00 29 05 L N

ATOM 6442 CD2 HIS L 198 43 030 -24. 936 -31 309 1.00 31.13 L c

ATOM 6444 C HIS L 198 46 537 -27. 017 -30 694 1.00 40 86 L c

ATOM 6445 O HIS L 198 47 762 -27. 002 -30 538 1.00 38 78 L 0

ATOM 6447 N GLN L 199 45 948 -27. 449 -31 807 1.00 44 99 L N

ATOM 6448 CA GLN L 199 46 681 -28. 051 -32 918 1.00 44 13 L c

ATOM 6450 CB GLN L 199 45 688 -28. 475 -33 998 1.00 46 58 L c

ATOM 6453 CG GLN L 199 46 252 -29. 410 -35 048 1.00 49 59 L c

ATOM 6456 CD GLN L 199 45 276 -29. 649 -36 182 1.00 51 64 L c

ATOM 6457 OEl GLN L 199 44 065 -29. 791 -35 958 1.00 51 22 L 0

ATOM 6458 NE2 GLN L 199 45 795 -29. 687 -37 414 1.00 52 35 L N

ATOM 6461 C GLN L 199 47 758 -27. 145 -33 532 1.00 42 62 L c

ATOM 6462 O GLN L 199 48 796 -27. 628 -33 984 1.00 44 60 L 0

ATOM 6464 N GLY L 200 47 509 -25. 841 -33 557 1.00 42 42 L N

ATOM 6465 CA GLY L 200 48 462 -24. 879 -34 117 1.00 43 36 L c

ATOM 6468 C GLY L 200 49 597 -24. 520 -33 171 1.00 44 08 L c

ATOM 6469 O GLY L 200 50 561 -23. 858 -33 574 1.00 37 85 L 0

ATOM 6471 N LEU L 201 49 463 -24. 938 -31 909 1.00 44 57 L N

ATOM 6472 CA LEU L 201 50 498 -24. 760 -30 897 1.00 45 78 L c

ATOM 6474 CB LEU L 201 49 870 -24. 493 -29 528 1.00 40 59 L c

ATOM 6477 CG LEU L 201 49 059 -23. 207 -29 397 1.00 35 81 L c

ATOM 6479 CDl LEU L 201 48 397 -23. 176 -28 040 1.00 31 44 L c

ATOM 6483 CD2 LEU L 201 49 924 -21.972 -29 622 1.00 34 38 L c

ATOM 6487 C LEU L 201 51 377 -26. 003 -30 809 1.00 49 77 L c

ATOM 6488 O LEU L 201 50 901 -27. 092 -30 462 1.00 50 88 L 0

ATOM 6490 N SER L 202 52 661 -25. 823 -31 117 1.00 52 93 L N

ATOM 6491 CA SER L 202 53 657 -26. 894 -31 019 1.00 51 96 L c

ATOM 6493 CB SER L 202 55 055 -26. 329 -31 288 1.00 54 75 L c

ATOM 6496 OG SER L 202 56 043 -27. 337 -31 175 1.00 56 78 L 0

ATOM 6498 C SER L 202 53 618 -27. 552 -29 642 1.00 53 84 L c

ATOM 6499 O SER L 202 53 763 -28. 771 -29 522 1.00 56 46 L 0

ATOM 6501 N SER L 203 53 432 -26. 727 -28 614 1.00 52 32 L N cyno fD_Fab

ATOM 6502 CA SER L 203 53 261 -27 191 -27 248 1 00 50. 89 L C

ATOM 6504 CB SER L 203 54. 622 -27 303 -26 557 1 00 52. 49 L C

ATOM 6507 OG SER L 203 55. 283 -26 048 -26 526 1 00 52. 37 L 0

ATOM 6509 C SER L 203 52. 376 -26 199 -26 493 1 00 50. 47 L c

ATOM 6510 O SER L 203 52. 338 -25 015 -26 849 1 00 50. 12 L 0

ATOM 6512 N PRO L 204 51. 684 -26 667 -25 434 1 00 49. 00 L N

ATOM 6513 CA PRO L 204 50 755 -25 831 -24 668 1 00 48. 32 L c

ATOM 6515 CB PRO L 204 50. 495 -26 661 -23 409 1 00 49. 24 L c

ATOM 6518 CG PRO L 204 50. 667 -28 059 -23 851 1 00 49. 62 L c

ATOM 6521 CD PRO L 204 51. 753 -28 036 -24 887 1 00 49. 96 L c

ATOM 6524 C PRO L 204 51.311 -24 461 -24 280 1 00 46. 81 L c

ATOM 6525 O PRO L 204 52. 472 -24 358 -23 890 1 00 49. 06 L 0

ATOM 6526 N VAL L 205 50. 473 -23 431 -24 401 1 00 46. 00 L N

ATOM 6527 CA VAL L 205 50. 804 -22 058 -24 007 1 00 44. 86 L c

ATOM 6529 CB VAL L 205 50. 323 -21 043 -25 067 1 00 43. 87 L c

ATOM 6531 CGI VAL L 205 50. 645 -19 625 -24 639 1 00 46. 06 L c

ATOM 6535 CG2 VAL L 205 50. 941 -21 346 -26 421 1 00 43. 83 L c

ATOM 6539 C VAL L 205 50. 113 -21 738 -22 683 1 00 43. 45 L c

ATOM 6540 O VAL L 205 48. 940 -22 068 -22 500 1 00 42. 63 L 0

ATOM 6542 N THR L 206 50. 841 -21 104 -21 764 1 00 42. 55 L N

ATOM 6543 CA THR L 206 50. 273 -20 667 -20 486 1 00 43. 06 L c

ATOM 6545 CB THR L 206 50. 985 -21 330 -19 278 1 00 42. 88 L c

ATOM 6547 OGl THR L 206 51. 035 -22 750 -19 472 1 00 45. 22 L 0

ATOM 6549 CG2 THR L 206 50. 254 -21 030 -17 977 1 00 39. 29 L c

ATOM 6553 C THR L 206 50. 351 -19 139 -20 364 1 00 43. 20 L c

ATOM 6554 O THR L 206 51.353 -18 516 -20 731 1 00 41. 18 L 0

ATOM 6556 N LYS L 207 49. 264 -18 550 -19 882 1 00 41. 82 L N

ATOM 6557 CA LYS L 207 49. 204 -17 132 -19 581 1 00 41. 36 L c

ATOM 6559 CB LYS L 207 48. 220 -16 423 -20 515 1 00 45. 01 L c

ATOM 6562 CG LYS L 207 48. 769 -16 159 -21 930 1 00 45. 79 L c

ATOM 6565 CD LYS L 207 49. 557 -14 843 -21.990 1 00 47. 42 L c

ATOM 6568 CE LYS L 207 50. 000 -14 473 -23 411 1 00 48. 29 L c

ATOM 6571 NZ LYS L 207 49. 741 -13 014 -23 711 1 00 48. 56 L N

ATOM 6575 C LYS L 207 48. 762 -17 033 -18 129 1 00 41. 24 L c

ATOM 6576 O LYS L 207 47. 902 -17 803 -17 683 1 00 34. 79 L 0

ATOM 6578 N SER L 208 49. 362 -16 104 -17 386 1 00 41. 46 L N

ATOM 6579 CA SER L 208 49. 163 -16 058 -15 943 1 00 39. 23 L c

ATOM 6581 CB SER L 208 50. 066 -17 094 -15 273 1 00 40. 60 L c

ATOM 6584 OG SER L 208 51. 421 -16 904 -15 653 1 00 42. 39 L 0

ATOM 6586 C SER L 208 49. 429 -14 693 -15 330 1 00 38. 28 L c

ATOM 6587 O SER L 208 50. 118 -13 853 -15 911 1 00 40. 12 L 0

ATOM 6589 N PHE L 209 48. 865 -14 493 -14 143 1 00 38. 02 L N

ATOM 6590 CA PHE L 209 49. 111 -13 303 -13 342 1 00 36. 29 L c

ATOM 6592 CB PHE L 209 47. 970 -12 289 -13 509 1 00 34. 61 L c

ATOM 6595 CG PHE L 209 46. 630 -12 754 -12 976 1 00 33. 86 L c

ATOM 6596 CDl PHE L 209 46. 292 -12 568 -11 643 1 00 32. 58 L c

ATOM 6598 CEl PHE L 209 45. 059 -12 974 -11.153 1 00 33. 77 L c

ATOM 6600 cz PHE L 209 44. 140 -13 557 -12 002 1 00 34. 43 L c

ATOM 6602 CE2 PHE L 209 44. 456 -13 733 -13 339 1 00 33. 37 L c

ATOM 6604 CD2 PHE L 209 45. 690 -13 327 -13 821 1 00 33. 14 L c

ATOM 6606 C PHE L 209 49. 269 -13 690 -11 884 1 00 36. 56 L c

ATOM 6607 0 PHE L 209 48. 859 -14 781 -11 485 1 00 34. 56 L 0

ATOM 6609 N ASN L 210 49. 877 -12 799 -11 098 1 00 38. 51 L N

ATOM 6610 CA ASN L 210 49. 932 -12 947 -9 640 1 00 39. 31 L c

ATOM 6612 CB ASN L 210 51. 326 -12 636 -9 108 1 00 40. 43 L c

ATOM 6615 CG ASN L 210 52. 384 -13 570 -9 653 1 00 41. 74 L c

ATOM 6616 ODl ASN L 210 52. 145 -14 766 -9 852 1 00 44. 55 L 0

ATOM 6617 ND2 ASN L 210 53. 573 -13 029 -9 887 1 00 42. 04 L N

ATOM 6620 C ASN L 210 48. 928 -11 994 -9 017 1 00 40. 31 L c

ATOM 6621 0 ASN L 210 48. 944 -10 795 -9 313 1 00 39. 80 L 0

ATOM 6623 N ARG L 211 48. 057 -12 528 -8 162 1 00 41. 37 L N

ATOM 6624 CA ARG L 211 46. 926 -11 773 -7 625 1 00 42. 74 L c

ATOM 6626 CB ARG L 211 46. 177 -12 612 -6 583 1 00 38. 76 L c

ATOM 6629 CG ARG L 211 45. 067 -11 867 -5 843 1 00 39. 89 L c

ATOM 6632 CD ARG L 211 44. 365 -12 757 -4 836 1 00 40. 10 L c

ATOM 6635 NE ARG L 211 45. 300 -13 300 -3 853 1 00 39. 72 L N

ATOM 6637 CZ ARG L 211 45. 559 -12 783 -2 650 1 00 39. 74 L c

ATOM 6638 NHl ARG L 211 44. 947 -11 683 -2 213 1 00 37. 79 L N cyno fD_Fab

ATOM 6641 NH2 ARG L 211 46. ,443 -13. ,392 -1. 863 1.00 38. ,19 L N

ATOM 6644 C ARG L 211 47. ,391 -10. ,443 -7. 019 1.00 47. ,84 L C

ATOM 6645 O ARG L 211 48. ,264 -10. 422 -6. ,149 1.00 47. ,51 L 0

ATOM 6647 N GLY L 212 46. ,817 -9. ,342 -7. 504 1.00 51. ,81 L N

ATOM 6648 CA GLY L 212 47. ,105 -8. ,003 -6. 981 1.00 52. ,44 L C

ATOM 6651 C GLY L 212 48. ,547 -7. 555 -7. 156 1.00 54. ,99 L C

ATOM 6652 O GLY L 212 49. ,141 -7. ,000 -6. 233 1.00 57. ,87 L 0

ATOM 6654 N GLU L 213 49. ,107 -7. ,782 -8. 344 1.00 56. ,81 L N

ATOM 6655 CA GLU L 213 50. ,524 -7. ,511 -8. 600 1.00 56. ,81 L c

ATOM 6657 CB GLU L 213 51. ,369 -8. 697 -8. 117 1.00 57. ,49 L c

ATOM 6660 CG GLU L 213 52. ,882 -8. 502 -8. 176 1.00 58. ,45 L c

ATOM 6663 CD GLU L 213 53. ,642 -9. 789 -7. 855 1.00 59. ,57 L c

ATOM 6664 OEl GLU L 213 54. ,234 -10. 389 -8. 783 1.00 59. ,90 L 0

ATOM 6665 OE2 GLU L 213 53. ,632 -10. 211 -6. 676 1.00 60. 08 L 0

ATOM 6666 C GLU L 213 50. ,766 -7. 252 -10. 084 1.00 56. 94 L c

ATOM 6667 O GLU L 213 50. ,335 -6. 230 -10. 619 1.00 56. ,25 L 0

ATOM 6669 N GLU H 1 10. ,286 1. 610 -47. 649 1.00 39. ,75 H N

ATOM 6670 CA GLU H 1 10. ,725 0. 187 -47. 539 1.00 41. .82 H c

ATOM 6672 CB GLU H 1 12, ,220 0. 107 -47. 113 1.00 48. ,22 H c

ATOM 6675 CG GLU H 1 12. ,541 -0. 356 -45. 650 1.00 51. ,94 H c

ATOM 6678 CD GLU H 1 12. 635 0. 768 -44. 592 1.00 54. ,37 H c

ATOM 6679 OEl GLU H 1 12. 218 1. 919 -44. 846 1.00 54. ,80 H 0

ATOM 6680 OE2 GLU H 1 13. 133 0. 477 -43. 477 1.00 54. ,44 H 0

ATOM 6681 C GLU H 1 9. 803 -0. 621 -46. 601 1.00 37. ,68 H c

ATOM 6682 O GLU H 1 9. 233 -0. 086 -45. 645 1.00 34. ,67 H 0

ATOM 6686 N VAL H 2 9. 674 -1. 917 -46. 877 1.00 36. 12 H N

ATOM 6687 CA VAL H 2 8. ,913 -2. ,810 -45. 998 1.00 34. ,66 H c

ATOM 6689 CB VAL H 2 8. 706 -4. 214 -46. 631 1.00 31. ,10 H c

ATOM 6691 CGI VAL H 2 8. ,009 -5. 158 -45. 646 1.00 25. ,65 H c

ATOM 6695 CG2 VAL H 2 7. 920 -4. 093 -47. 936 1.00 26. ,85 H c

ATOM 6699 C VAL H 2 9. 622 -2. 964 -44. 658 1.00 33. ,46 H c

ATOM 6700 O VAL H 2 10. ,829 -3. 172 -44. 604 1.00 35. ,64 H 0

ATOM 6702 N GLN H 3 8. 869 -2. 852 -43. 578 1.00 31. ,66 H N

ATOM 6703 CA GLN H 3 9. ,391 -3. 150 -42. 259 1.00 34. ,98 H c

ATOM 6705 CB GLN H 3 9. ,676 -1. 867 -41.484 1.00 38. ,83 H c

ATOM 6708 CG GLN H 3 11. ,139 -1. 494 -41. 359 1.00 44. ,13 H c

ATOM 6711 CD GLN H 3 11. ,355 -0. 392 -40. 303 1.00 45. ,42 H c

ATOM 6712 OEl GLN H 3 12. ,100 -0. 577 -39. 331 1.00 48. ,14 H 0

ATOM 6713 NE2 GLN H 3 10. ,680 0. 748 -40. 485 1.00 47. ,28 H N

ATOM 6716 C GLN H 3 8. ,382 -3. 983 -41. 487 1.00 28. ,77 H c

ATOM 6717 O GLN H 3 7. ,182 -3. 769 -41.604 1.00 24. ,59 H 0

ATOM 6719 N LEU H 4 8. ,900 -4. 943 -40. 728 1.00 30. ,43 H N

ATOM 6720 CA LEU H 4 8. ,152 -5. ,687 -39. 728 1.00 29. ,17 H c

ATOM 6722 CB LEU H 4 8. ,052 -7. ,165 -40. 118 1.00 32. ,01 H c

ATOM 6725 CG LEU H 4 7. ,346 -7. 459 -41. 443 1.00 30. ,46 H c

ATOM 6727 CDl LEU H 4 7. ,371 -8. ,912 -41. 725 1.00 28. ,18 H c

ATOM 6731 CD2 LEU H 4 5. ,908 -6. 959 -41. 395 1.00 23. ,08 H c

ATOM 6735 C LEU H 4 8. ,918 -5. 551 -38. 418 1.00 27. ,12 H c

ATOM 6736 0 LEU H 4 10. ,064 -5. 984 -38. 315 1.00 31. ,47 H 0

ATOM 6738 N VAL H 5 8. ,283 -4. 951 -37. 426 1.00 25. ,43 H N

ATOM 6739 CA VAL H 5 8. ,887 -4. ,724 -36. 127 1.00 27. ,06 H c

ATOM 6741 CB VAL H 5 8. ,870 -3. ,222 -35. 736 1.00 23. .44 H C

ATOM 6743 CGI VAL H 5 9. ,419 -3. ,035 -34. 322 1.00 19. ,35 H c

ATOM 6747 CG2 VAL H 5 9. ,675 -2. ,397 -36. 742 1.00 25. .50 H c

ATOM 6751 C VAL H 5 8. ,093 -5. 499 -35. 088 1.00 28. ,22 H c

ATOM 6752 O VAL H 5 6. ,910 -5. ,212 -34. 855 1.00 19. ,40 H 0

ATOM 6754 N GLN H 6 8. ,748 -6. 475 -34. 465 1.00 26. ,67 H N

ATOM 6755 CA GLN H 6 8. ,118 -7. 273 -33. 428 1.00 25. ,18 H c

ATOM 6757 CB GLN H 6 8. ,625 -8. 699 -33. 487 1.00 24. .68 H c

ATOM 6760 CG GLN H 6 8. ,466 -9. ,320 -34. 877 1.00 25. .18 H c

ATOM 6763 CD GLN H 6 8. ,940 -10. ,737 -34. 931 1.00 20. .61 H c

ATOM 6764 OEl GLN H 6 9. ,741 -11. ,100 -35. ,787 1.00 25, .23 H 0

ATOM 6765 NE2 GLN H 6 8. ,457 -11. ,551 -34. ,019 1.00 17. .17 H N

ATOM 6768 C GLN H 6 8. ,384 -6. 685 -32. 058 1.00 25, .80 H c

ATOM 6769 O GLN H 6 9. ,347 -5. ,950 -31. 872 1.00 23. ,83 H 0

ATOM 6771 N SER H 7 7. 520 -7. ,030 -31. 108 1.00 24. .20 H N

ATOM 6772 CA SER H 7 7. ,614 -6. 538 -29. 744 1.00 26. .00 H c

ATOM 6774 CB SER H 7 6. 322 -6. 863 -28. 988 1.00 25. ,41 H c cyno fD_Fab

ATOM 6777 OG SER H 7 5. .974 -8. 213 -29. ,218 1.00 27. 49 H 0

ATOM 6779 C SER H 7 8. ,828 -7 . 120 -29. ,021 1.00 23. 30 H C

ATOM 6780 O SER H 7 9. ,489 -8. 029 -29. ,521 1.00 29. ,43 H 0

ATOM 6782 N GLY H 8 9. ,109 -6. 580 -27, ,837 1.00 29. ,18 H N

ATOM 6783 CA GLY H 8 10. ,309 -6. 919 -27. ,076 1.00 27. ,92 H C

ATOM 6786 C GLY H 8 10. ,301 -8. 326 -26. .498 1.00 27. ,24 H C

ATOM 6787 O GLY H 8 9. ,258 -8. 974 -26. ,479 1.00 27. ,87 H 0

ATOM 6789 N PRO H 9 11. ,468 -8. 795 -26, ,006 1.00 25. ,98 H N

ATOM 6790 CA PRO H 9 11. ,608 -10. 119 -25. ,419 1.00 28. ,15 H C

ATOM 6792 CB PRO H 9 13. ,099 -10. 198 -25. ,078 1.00 28. 95 H c

ATOM 6795 CG PRO H 9 13. ,500 -8. 797 -24. ,873 1.00 28. ,98 H c

ATOM 6798 CD PRO H 9 12. ,737 -8. 050 -25. ,930 1.00 28. ,19 H c

ATOM 6801 C PRO H 9 10. ,792 -10. 224 -24. ,154 1.00 26. ,75 H c

ATOM 6802 O PRO H 9 10. ,654 -9. 237 -23. .443 1.00 29. ,13 H 0

ATOM 6803 N GLU H 10 10. ,256 -11. 408 -23. ,885 1.00 27. ,88 H N

ATOM 6804 CA GLU H 10 9. ,400 -11. 613 -22. ,729 1.00 30. , 77 H c

ATOM 6806 CB GLU H 10 7. ,964 -11. 875 -23. ,170 1.00 34. ,61 H c

ATOM 6809 CG GLU H 10 7. ,389 -10. 792 -24. ,052 1.00 36. ,72 H c

ATOM 6812 CD GLU H 10 6. ,065 -10. 269 -23. ,561 1.00 37. ,81 H c

ATOM 6813 OEl GLU H 10 5. 379 -9. 612 -24. ,364 1.00 43. ,27 H 0

ATOM 6814 OE2 GLU H 10 5. ,716 -10. 489 -22. ,381 1.00 37. ,47 H 0

ATOM 6815 C GLU H 10 9. ,861 -12. 785 -21. .908 1.00 28. ,91 H c

ATOM 6816 O GLU H 10 10. ,445 -13. 731 -22. ,430 1.00 32. 68 H 0

ATOM 6818 N LEU H 11 9. ,594 -12. 704 -20. ,612 1.00 32. ,05 H N

ATOM 6819 CA LEU H 11 9. ,743 -13. 826 -19. ,707 1.00 31. 21 H C

ATOM 6821 CB LEU H 11 10. 733 -13. 512 -18. ,595 1.00 32. ,30 H C

ATOM 6824 CG LEU H 11 10. ,801 -14. 497 -17. ,420 1.00 32. ,01 H c

ATOM 6826 CDl LEU H 11 11. ,475 -15. 788 -17. ,853 1.00 28. ,98 H c

ATOM 6830 CD2 LEU H 11 11. ,533 -13. 851 -16. ,253 1.00 28. ,96 H c

ATOM 6834 C LEU H 11 8. ,374 -14. 083 -19. .117 1.00 32. ,87 H c

ATOM 6835 O LEU H 11 7. ,689 -13. 152 -18. ,673 1.00 28. ,57 H 0

ATOM 6837 N LYS H 12 7. ,978 -15. 348 -19. ,129 1.00 33. ,56 H N

ATOM 6838 CA LYS H 12 6. ,688 -15. 761 -18. ,613 1.00 34. 28 H c

ATOM 6840 CB LYS H 12 5. ,693 -15. 988 -19. ,765 1.00 34. 85 H c

ATOM 6843 CG LYS H 12 5. 226 -14. 701 -20. ,479 1.00 33. 62 H c

ATOM 6846 CD LYS H 12 4. ,329 -13. 842 -19. ,583 1.00 35. ,48 H c

ATOM 6849 CE LYS H 12 3. ,972 -12. 525 -20. ,250 1.00 36. ,01 H c

ATOM 6852 NZ LYS H 12 3. ,050 -11. 711 -19, .416 1.00 32. ,22 H N

ATOM 6856 C LYS H 12 6. ,897 -17. 036 -17. ,833 1.00 34. ,16 H c

ATOM 6857 O LYS H 12 7. ,882 -17. 740 -18. ,053 1.00 35. ,65 H 0

ATOM 6859 N LYS H 13 5. ,975 -17. 329 -16. .922 1.00 29. ,60 H N

ATOM 6860 CA LYS H 13 6. ,024 -18. 574 -16. ,158 1.00 33. ,14 H C

ATOM 6862 CB LYS H 13 5. ,369 -18. 375 -14. ,795 1.00 32. ,40 H C

ATOM 6865 CG LYS H 13 5. ,956 -17. 211 -14. ,021 1.00 34. ,58 H c

ATOM 6868 CD LYS H 13 5. ,425 -17. 159 -12. ,588 1.00 33. ,80 H c

ATOM 6871 CE LYS H 13 6. ,438 -16. 513 -11.647 1.00 34. ,88 H c

ATOM 6874 NZ LYS H 13 7 . ,718 -17. 290 -11, .602 1.00 30. ,90 H N

ATOM 6878 C LYS H 13 5. ,308 -19. 684 -16, .926 1.00 32. ,01 H c

ATOM 6879 0 LYS H 13 4. ,576 -19. 398 -17, .875 1.00 24. ,84 H 0

ATOM 6881 N PRO H 14 5. ,510 -20. 957 -16. .524 1.00 36. ,35 H N

ATOM 6882 CA PRO H 14 4. ,741 -22. 022 -17. .183 1.00 36. ,88 H c

ATOM 6884 CB PRO H 14 5. 432 -23. 316 -16. .707 1.00 39. ,73 H c

ATOM 6887 CG PRO H 14 6. ,708 -22. 869 -16. ,013 1.00 38. ,39 H c

ATOM 6890 CD PRO H 14 6. ,415 -21. 497 -15, .495 1.00 36. ,38 H c

ATOM 6893 C PRO H 14 3. ,264 -21. 982 -16, .765 1.00 38. ,06 H c

ATOM 6894 0 PRO H 14 2. ,958 -21. 647 -15, .617 1.00 30. ,24 H 0

ATOM 6895 N GLY H 15 2. ,361 -22. 291 -17, .696 1.00 37. ,19 H N

ATOM 6896 CA GLY H 15 0. ,918 -22. 159 -17, .445 1.00 37. ,08 H c

ATOM 6899 C GLY H 15 0. ,364 -20. 762 -17, .706 1.00 36. ,37 H C

ATOM 6900 0 GLY H 15 -0. ,838 -20. 543 -17, .573 1.00 33. ,44 H 0

ATOM 6902 N ALA H 16 1. ,235 -19. 824 -18, .087 1.00 33. .93 H N

ATOM 6903 CA ALA H 16 0. ,841 -18. 450 -18, .408 1.00 32. .50 H C

ATOM 6905 CB ALA H 16 1. ,901 -17. 466 -17, .900 1.00 27. ,00 H C

ATOM 6909 C ALA H 16 0. ,635 -18. 281 -19, .917 1.00 31. ,31 H C

ATOM 6910 0 ALA H 16 0. ,903 -19. 196 -20, .689 1.00 32. ,02 H 0

ATOM 6912 N SER H 17 0. ,164 -17. 103 -20, .326 1.00 31.75 H H

ATOM 6913 CA SER H 17 -0. ,026 -16. 767 -21, .744 1.00 32. ,59 H c

ATOM 6915 CB SER H 17 -1. ,514 -16. 487 -22, .028 1.00 36. ,70 H c cyno fD_Fab

ATOM 6918 OG SER H 17 -2. ,346 -17. 540 -21.548 1.00 38. 32 H 0

ATOM 6920 C SER H 17 0. ,822 -15. 545 -22. 148 1.00 30. ,65 H C

ATOM 6921 O SER H 17 1. ,011 -14. 626 -21.350 1.00 27. 89 H 0

ATOM 6923 N VAL H 18 1. ,324 -15. 543 -23. ,384 1.00 25. 46 H N

ATOM 6924 CA VAL H 18 2. ,073 -14. 401 -23. ,936 1.00 27. 10 H C

ATOM 6926 CB VAL H 18 3. ,575 -14. 773 -24. ,210 1.00 29. ,42 H C

ATOM 6928 CGI VAL H 18 3. ,670 -15. 920 -25. ,163 1.00 23. 50 H C

ATOM 6932 CG2 VAL H 18 4. ,361 -13. 590 -24. .759 1.00 28. 90 H C

ATOM 6936 C VAL H 18 1. ,414 -13. 943 -25. ,237 1.00 29. 54 H C

ATOM 6937 O VAL H 18 0. ,820 -14. 748 -25. 952 1.00 29. 96 H 0

ATOM 6939 N LYS H 19 1. ,525 -12. 652 -25. ,539 1.00 30. 13 H N

ATOM 6940 CA LYS H 19 1. ,005 -12. 100 -26. ,782 1.00 30. 27 H C

ATOM 6942 CB LYS H 19 -0. ,249 -11. 269 -26. ,512 1.00 35. 10 H c

ATOM 6945 CG LYS H 19 -1. ,151 -11. 030 -27. ,727 1.00 34. 09 H c

ATOM 6948 CD LYS H 19 -2. ,403 -10. 251 -27. ,282 1.00 35. ,85 H c

ATOM 6951 CE LYS H 19 -3, ,426 -10. 039 -28. ,411 1.00 37. ,19 H c

ATOM 6954 NZ LYS H 19 -4. ,539 -9. 080 -28. ,018 1.00 32. 60 H N

ATOM 6958 C LYS H 19 2. ,098 -11. 253 -27. ,434 1.00 31.79 H c

ATOM 6959 O LYS H 19 2. ,430 -10. 177 -26. ,938 1.00 33. 02 H 0

ATOM 6961 N VAL H 20 2. ,661 -11. 762 -28. ,533 1.00 26. 35 H H

ATOM 6962 CA VAL H 20 3. ,730 -11. 098 -29. ,259 1.00 27. 87 H c

ATOM 6964 CB VAL H 20 4. ,776 -12. 133 -29. ,702 1.00 31. 05 H c

ATOM 6966 CGI VAL H 20 5. ,744 -11. 543 -30. ,734 1.00 33. ,46 H c

ATOM 6970 CG2 VAL H 20 5. ,511 -12. 682 -28. ,481 1.00 29. 03 H c

ATOM 6974 C VAL H 20 3. ,147 -10. 397 -30. ,485 1.00 28. 99 H c

ATOM 6975 O VAL H 20 2. ,319 -10. 969 -31.176 1.00 28. 18 H 0

ATOM 6977 N SER H 21 3. ,582 -9. 168 -30. ,761 1.00 28. 88 H N

ATOM 6978 CA SER H 21 3. ,043 -8. 398 -31. ,889 1.00 29. 76 H c

ATOM 6980 CB SER H 21 2. ,573 -7. 009 -31. ,427 1.00 35. 28 H c

ATOM 6983 OG SER H 21 3. ,658 -6. 157 -31. 111 1.00 39. ,69 H 0

ATOM 6985 C SER H 21 4. ,029 -8. 277 -33. ,049 1.00 27. 68 H c

ATOM 6986 O SER H 21 5. ,225 -8. 480 -32. ,881 1.00 25. ,72 H 0

ATOM 6988 N CYS H 22 3. ,502 -7. 964 -34. ,229 1.00 28. 49 H N

ATOM 6989 CA CYS H 22 4. ,304 -7. 812 -35. 441 1.00 27. 06 H c

ATOM 6991 CB CYS H 22 4. ,354 -9. 129 -36. ,211 1.00 27. 55 H c

ATOM 6994 SG CYS H 22 5. ,200 -9. 020 -37. ,835 1.00 25. 45 H s

ATOM 6996 C CYS H 22 3. ,734 -6. 653 -36. ,294 1.00 29. 35 H c

ATOM 6997 O CYS H 22 2, ,932 -6. 849 -37. ,203 1.00 29. ,28 H 0

ATOM 6999 N LYS H 23 4. ,150 -5. 437 -35. ,962 1.00 30. ,17 H N

ATOM 7000 CA LYS H 23 3. ,722 -4. 235 -36. ,664 1.00 26. ,52 H c

ATOM 7002 CB LYS H 23 4. ,114 -2. 998 -35. ,853 1.00 30. 79 H c

ATOM 7005 CG LYS H 23 3. ,898 -1. 647 -36. 553 1.00 31. 86 H c

ATOM 7008 CD LYS H 23 2. ,435 -1. 286 -36. ,647 1.00 32. 60 H c

ATOM 7011 CE LYS H 23 2. ,215 0. 056 -37. ,352 1.00 31. 86 H c

ATOM 7014 NZ LYS H 23 2. ,105 -0. 122 -38. ,834 1.00 30. ,34 H N

ATOM 7018 C LYS H 23 4. ,346 -4. 166 -38. ,039 1.00 24. 60 H c

ATOM 7019 0 LYS H 23 5, ,569 -4. 167 -38. ,164 1.00 26. ,34 H 0

ATOM 7021 N ALA H 24 3. ,507 -4. 092 -39. ,069 1.00 25. ,08 H N

ATOM 7022 CA ALA H 24 3. ,975 -4. 065 -40. ,455 1.00 24. 99 H c

ATOM 7024 CB ALA H 24 3, ,108 -4. 977 -41. ,320 1.00 23. ,97 H c

ATOM 7028 C ALA H 24 3, ,942 -2. 648 -41. ,006 1.00 21. ,49 H c

ATOM 7029 O ALA H 24 3, ,073 -1. 881 -40. ,647 1.00 19. ,24 H 0

ATOM 7031 N SER H 25 4. ,891 -2. 300 -41. ,875 1.00 22. ,75 H N

ATOM 7032 CA SER H 25 4. .850 -0. 998 -42. .553 1.00 28. ,27 H c

ATOM 7034 CB SER H 25 5. .467 0. 116 -41. ,671 1.00 31. ,66 H c

ATOM 7037 OG SER H 25 6. ,819 -0. 133 -41.321 1.00 34. ,02 H 0

ATOM 7039 C SER H 25 5. .468 -1. 023 -43. ,947 1.00 29. ,64 H c

ATOM 7040 O SER H 25 6. ,185 -1. 961 -44. ,325 1.00 28. ,38 H 0

ATOM 7042 N GLY H 26 5. ,124 -0. 016 -44. ,740 1.00 29. ,77 H N

ATOM 7043 CA GLY H 26 5. ,691 0. 120 -46. ,075 1.00 30. ,39 H c

ATOM 7046 C GLY H 26 5. ,097 -0. 799 -47. ,119 1.00 30. ,05 H c

ATOM 7047 O GLY H 26 5. ,678 -0. 981 -48. ,192 1.00 30. ,89 H 0

ATOM 7049 N TYR H 27 3. .945 -1. 385 -46. .804 1.00 30. ,64 H N

ATOM 7050 CA TYR H 27 3. .145 -2. 141 -47. ,778 1.00 29. ,71 H c

ATOM 7052 CB TYR H 27 3. ,740 -3. 544 -48, ,015 1.00 27. ,92 H c

ATOM 7055 CG TYR H 27 3. ,486 -4. 516 -46. ,884 1.00 25. ,96 H c

ATOM 7056 CDl TYR H 27 2. ,454 -5. 445 -46. ,950 1.00 28. ,29 H c

ATOM 7058 CEl TYR H 27 2. ,200 -6. 326 -45. ,889 1.00 26. ,48 H c cyno fD_Fab

ATOM 7060 CZ TYR H 27 2.998 -6 284 -44 771 1.00 26 96 H C

ATOM 7061 OH TYR H 27 2.793 -7 152 -43 721 1.00 28 81 H 0

ATOM 7063 CE2 TYR H 27 4.016 -5 363 -44 687 1.00 28 69 H C

ATOM 7065 CD2 TYR H 27 4.264 -4 497 -45 742 1.00 27 47 H C

ATOM 7067 C TYR H 27 1.704 -2 235 -47 246 1.00 28 80 H c

ATOM 7068 O TYR H 27 1.456 -1 890 -46 087 1.00 23 70 H 0

ATOM 7070 N THR H 28 0.769 -2 704 -48 077 1.00 29 08 H N

ATOM 7071 CA THR H 28 -0.626 -2 857 -47 655 1.00 26 82 H c

ATOM 7073 CB THR H 28 -1.639 -2 833 -48 835 1.00 31 54 H c

ATOM 7075 OGl THR H 28 -1.405 -1 692 -49 666 1.00 37 18 H 0

ATOM 7077 CG2 THR H 28 -3.070 -2 745 -48 312 1.00 29 93 H c

ATOM 7081 C THR H 28 -0.748 -4 165 -46 892 1.00 24 49 H c

ATOM 7082 O THR H 28 -0.569 -5 248 -47 446 1.00 19 85 H 0

ATOM 7084 N PHE H 29 -1.035 -4 042 -45 602 1.00 21 30 H N

ATOM 7085 CA PHE H 29 -1.041 -5 164 -44 673 1.00 20 29 H c

ATOM 7087 CB PHE H 29 -1.545 -4 658 -43 308 1.00 17 82 H c

ATOM 7090 CG PHE H 29 -1.486 -5 671 -42 192 1.00 16 83 H c

ATOM 7091 CDl PHE H 29 -0.294 -6 274 -41 842 1.00 18 76 H c

ATOM 7093 CE1 PHE H 29 -0.237 -7 174 -40 798 1.00 18 63 H c

ATOM 7095 CZ PHE H 29 -1.387 -7 456 -40 070 1.00 19 20 H c

ATOM 7097 CE2 PHE H 29 -2.568 -6 851 -40 396 1.00 16 13 H c

ATOM 7099 CD2 PHE H 29 -2.617 -5 954 -41 436 1.00 17 98 H c

ATOM 7101 C PHE H 29 -1.927 -6 279 -45 195 1.00 22 64 H c

ATOM 7102 O PHE H 29 -1.487 -7 408 -45 335 1.00 26 18 H 0

ATOM 7104 N THR H 30 -3.170 -5 936 -45 526 1.00 24 43 H N

ATOM 7105 CA THR H 30 -4.206 -6 921 -45 885 1.00 22 13 H c

ATOM 7107 CB THR H 30 -5.580 -6 268 -45 795 1.00 22 87 H c

ATOM 7109 OGl THR H 30 -5.601 -5 111 -46 641 1.00 26 55 H 0

ATOM 7111 CG2 THR H 30 -5.871 -5 856 -44 342 1.00 16 64 H c

ATOM 7115 C THR H 30 -4.056 -7 567 -47 274 1.00 23 27 H c

ATOM 7116 O THR H 30 -4.857 -8 415 -47 639 1.00 22 74 H 0

ATOM 7118 N ASN H 31 -3.018 -7 184 -48 019 1.00 21 42 H N

ATOM 7119 CA ASN H 31 -2.749 -7 716 -49 344 1.00 23 38 H C

ATOM 7121 CB ASN H 31 -2.259 -6 593 -50 267 1.00 25 98 H C

ATOM 7124 CG ASN H 31 -3.378 -5 716 -50 778 1.00 28 74 H c

ATOM 7125 ODl ASN H 31 -4.555 -5 857 -50 404 1.00 38 11 H 0

ATOM 7126 ND2 ASN H 31 -3.017 -4 794 -51 637 1.00 31 93 H N

ATOM 7129 C ASN H 31 -1.720 -8 848 -49 365 1.00 23 17 H c

ATOM 7130 O ASN H 31 -1.523 -9 489 -50 412 1.00 23 34 H 0

ATOM 7132 N TYR H 32 -1.040 -9 047 -48 240 1.00 21 70 H N

ATOM 7133 CA TYR H 32 -0.125 -10 163 -48 036 1.00 25 03 H c

ATOM 7135 CB TYR H 32 1.323 -9 686 -47 940 1.00 25 90 H c

ATOM 7138 CG TYR H 32 1.841 -8 978 -49 158 1.00 26 41 H c

ATOM 7139 CDl TYR H 32 2.727 -9 594 -50 023 1.00 28 29 H c

ATOM 7141 CEl TYR H 32 3.205 -8 939 -51 133 1.00 24 73 H c

ATOM 7143 CZ TYR H 32 2.803 -7 638 -51 360 1.00 26 55 H c

ATOM 7144 OH TYR H 32 3.249 -6 942 -52 449 1.00 31 83 H 0

ATOM 7146 CE2 TYR H 32 1.944 -7 022 -50 518 1.00 23 42 H c

ATOM 7148 CD2 TYR H 32 1.469 -7 685 -49 427 1.00 25 06 H c

ATOM 7150 C TYR H 32 -0.460 -10 801 -46 715 1.00 22 75 H c

ATOM 7151 O TYR H 32 -0.673 -10 091 -45 753 1.00 23 83 H 0

ATOM 7153 N GLY H 33 -0.472 -12 129 -46 647 1.00 23 62 H N

ATOM 7154 CA GLY H 33 -0.644 -12 815 -45 370 1.00 23 53 H c

ATOM 7157 C GLY H 33 0.623 -12 766 -44 532 1.00 25 13 H c

ATOM 7158 O GLY H 33 1.635 -12 194 -44 951 1.00 23 95 H 0

ATOM 7160 N MET H 34 0.566 -13 358 -43 341 1.00 26 29 H N

ATOM 7161 CA MET H 34 1.709 -13 380 -42 426 1.00 24 74 H c

ATOM 7163 CB MET H 34 1.425 -12 494 -41 207 1.00 27 32 H c

ATOM 7166 CG MET H 34 2.668 -12 129 -40 366 1.00 25 13 H c

ATOM 7169 SD MET H 34 3.708 -10 917 -41 189 1.00 25 78 H S

ATOM 7170 CE MET H 34 2.842 -9 410 -40 934 1.00 22 76 H c

ATOM 7174 C MET H 34 2.012 -14 806 -41 956 1.00 23 02 H c

ATOM 7175 0 MET H 34 1.120 -15 518 -41 524 1.00 15 73 H 0

ATOM 7177 N ASN H 35 3.271 -15 232 -42 041 1.00 24 66 H N

ATOM 7178 CA ASN H 35 3.647 -16 491 -41 401 1.00 23 84 H C

ATOM 7180 CB ASN H 35 4.590 -17 289 -42 278 1.00 21 17 H C

ATOM 7183 CG ASN H 35 4.083 -17 434 -43 675 1.00 23 27 H c

ATOM 7184 ODl ASN H 35 2.878 -17 536 -43 919 1.00 26 93 H 0 cyno fD_Fab

ATOM 7185 ND2 ASN H 35 4. 989 -17. ,426 -44. 607 1. 00 16. 57 H N

ATOM 7188 C ASN H 35 4. 273 -16. 268 -40. 038 1. 00 21. 88 H C

ATOM 7189 O ASN H 35 4. 813 -15. ,194 -39. ,748 1. 00 20. 56 H 0

ATOM 7191 N TRP H 36 4. 171 -17. 292 -39. ,198 1. 00 25. 58 H N

ATOM 7192 CA TRP H 36 4. 910 -17. 350 -37. ,948 1. 00 25. 77 H C

ATOM 7194 CB TRP H 36 3. 968 -17. ,429 -36. ,753 1. 00 23. 88 H c

ATOM 7197 CG TRP H 36 3. 217 -16. ,165 -36. ,544 1. 00 27. 31 H c

ATOM 7198 CDl TRP H 36 1. 997 -15. .858 -37. ,056 1. 00 26. 05 H c

ATOM 7200 NEl TRP H 36 1. 621 -14. ,608 -36. ,667 1. 00 24. 40 H N

ATOM 7202 CE2 TRP H 36 2. 591 -14. 069 -35. 865 1. 00 24. 27 H c

ATOM 7203 CD2 TRP H 36 3. 622 -15. ,025 -35. ,761 1. 00 26. 62 H c

ATOM 7204 CE3 TRP H 36 4. 756 -14. ,718 -34. 993 1. 00 27. 01 H c

ATOM 7206 CZ3 TRP H 36 4. 809 -13. ,469 -34. ,343 1. 00 26. 89 H c

ATOM 7208 CH2 TRP H 36 3. 760 -12. ,542 -34. ,471 1. 00 25. 94 H c

ATOM 7210 CZ2 TRP H 36 2. 646 -12. 823 -35. ,223 1. 00 25. 33 H c

ATOM 7212 C TRP H 36 5. 852 -18. ,544 -37. ,972 1. 00 22. 47 H c

ATOM 7213 O TRP H 36 5. 453 -19. ,649 -38. ,322 1. 00 22. 97 H 0

ATOM 7215 N VAL H 37 7. 100 -18. ,291 -37. ,596 1. 00 24. 90 H N

ATOM 7216 CA VAL H 37 8. 165 -19. ,291 -37. ,549 1. 00 26. 36 H c

ATOM 7218 CB VAL H 37 9. 235 -18. ,937 -38. ,593 1. 00 24. 69 H c

ATOM 7220 CGI VAL H 37 10. 385 -19. ,927 -38. ,577 1. 00 30. 64 H c

ATOM 7224 CG2 VAL H 37 8. 603 -18. ,874 -39. ,985 1. 00 22. 71 H c

ATOM 7228 C VAL H 37 8. 767 -19. 296 -36. ,125 1. 00 25. 33 H c

ATOM 7229 O VAL H 37 9. 062 -18. 238 -35. ,600 1. 00 17. 47 H 0

ATOM 7231 N ARG H 38 8. 941 -20. ,459 -35. ,493 1. 00 24. 74 H N

ATOM 7232 CA ARG H 38 9. 720 -20. ,515 -34. ,249 1. 00 22. 87 H c

ATOM 7234 CB ARG H 38 8. 899 -21. ,121 -33. ,094 1. 00 20. 73 H c

ATOM 7237 CG ARG H 38 9. 215 -22. ,518 -32. ,622 1. 00 19. 62 H c

ATOM 7240 CD ARG H 38 8. 796 -22. ,683 -31. ,163 1. 00 27. 00 H c

ATOM 7243 NE ARG H 38 8. 378 -24. .049 -30. ,874 1. 00 28. 33 H N

ATOM 7245 cz ARG H 38 9. 041 -24. ,932 -30. ,126 1. 00 35. 42 H c

ATOM 7246 NHl ARG H 38 10. 190 -24. ,633 -29. ,535 1. 00 39. 60 H N

ATOM 7249 NH2 ARG H 38 8. 526 -26. ,145 -29. ,956 1. 00 38. 05 H N

ATOM 7252 C ARG H 38 11. 102 -21. ,177 -34. ,381 1. 00 18. 54 H c

ATOM 7253 0 ARG H 38 11. 282 -22. ,103 -35. ,127 1. 00 26. 96 H 0

ATOM 7255 N GLN H 39 12. 074 -20. ,651 -33. ,636 1. 00 26. 17 H N

ATOM 7256 CA GLN H 39 13. 370 -21. ,276 -33. ,442 1. 00 23. 54 H c

ATOM 7258 CB GLN H 39 14. 439 -20. ,463 -34. ,160 1. 00 26. 29 H c

ATOM 7261 CG GLN H 39 15. 665 -21. ,253 -34. ,550 1. 00 25. 57 H c

ATOM 7264 CD GLN H 39 16. 622 -20. ,431 -35. ,359 1. 00 25. 96 H c

ATOM 7265 OEl GLN H 39 16. 725 -19. ,217 -35. ,166 1. 00 25. 15 H 0

ATOM 7266 NE2 GLN H 39 17. 327 -21, ,077 -36. ,282 1. 00 24. 26 H N

ATOM 7269 C GLN H 39 13. 707 -21. .429 -31. ,937 1. 00 26. 24 H C

ATOM 7270 O GLN H 39 13. 967 -20. ,459 -31. ,227 1. 00 19. 16 H 0

ATOM 7272 N ALA H 40 13. 683 -22. ,664 -31. ,454 1. 00 28. 95 H N

ATOM 7273 CA ALA H 40 14. 158 -22. ,963 -30. ,120 1. 00 27. 06 H C

ATOM 7275 CB ALA H 40 13. 771 -24. ,384 -29. ,720 1. 00 27. 79 H C

ATOM 7279 C ALA H 40 15. 681 -22. .779 -30. ,093 1. 00 26. 83 H C

ATOM 7280 O ALA H 40 16. 332 -22. ,867 -31.148 1. 00 28. 37 H 0

ATOM 7282 N PRO H 41 16. 246 -22. .479 -28. ,900 1. 00 30. 34 H N

ATOM 7283 CA PRO H 41 17. 676 -22. ,244 -28. ,702 1. 00 30. 06 H c

ATOM 7285 CB PRO H 41 17. 816 -22. .188 -27. ,179 1. 00 33. 23 H c

ATOM 7288 CG PRO H 41 16. 504 -21. ,696 -26. ,714 1. 00 32. 08 H c

ATOM 7291 CD PRO H 41 15. 494 -22. ,288 -27. ,640 1. 00 31. 46 H c

ATOM 7294 C PRO H 41 18. 572 -23. .323 -29. ,284 1. 00 31. 23 H c

ATOM 7295 O PRO H 41 18. 616 -24. ,442 -28. .774 1. 00 31. 51 H 0

ATOM 7296 N GLY H 42 19. 270 -22. .971 -30, ,357 1. 00 28. 45 H N

ATOM 7297 CA GLY H 42 20. 223 -23. .872 -30. .978 1. 00 31. 51 H C

ATOM 7300 C GLY H 42 19. 611 -24. ,771 -32. .028 1. 00 34. 49 H c

ATOM 7301 O GLY H 42 20. 324 -25. .546 -32. ,656 1. 00 34. 19 H 0

ATOM 7303 N GLN H 43 18. 299 -24. .637 -32. .245 1. 00 37. 22 H N

ATOM 7304 CA GLN H 43 17. 541 -25. ,573 -33. .074 1. 00 32. 28 H c

ATOM 7306 CB GLN H 43 16. 246 -25. .976 -32. ,356 1. 00 39. ,11 H c

ATOM 7309 CG GLN H 43 16. 298 -27. .359 -31. .730 1. 00 45. 11 H c

ATOM 7312 CD GLN H 43 17. 330 -27. ,455 -30. ,644 1. 00 50. ,05 H c

ATOM 7313 OEl GLN H 43 17. 215 -26. .800 -29. ,608 1. 00 54. 70 H 0

ATOM 7314 NE2 GLN H 43 18. 355 -28. .271 -30. ,870 1. 00 48. 78 H N

ATOM 7317 C GLN H 43 17. 237 -25. ,008 -34. ,459 1. ,00 30. 10 H C cyno fD_Fab

ATOM 7318 O GLN H 43 17. ,662 -23. ,901 -34. ,796 1.00 34. 64 H 0

ATOM 7320 N GLY H 44 16. ,534 -25. ,797 -35. ,270 1.00 27. 70 H N

ATOM 7321 CA GLY H 44 16. ,124 -25. ,380 -36. ,611 1.00 22. 82 H C

ATOM 7324 C GLY H 44 14. ,866 -24. ,515 -36. 625 1.00 18. 17 H C

ATOM 7325 O GLY H 44 14. ,155 -24. ,384 -35. ,612 1.00 22. 53 H 0

ATOM 7327 N LEU H 45 14. 579 -23. ,974 -37. ,804 1.00 18. 71 H N

ATOM 7328 CA LEU H 45 13. 366 -23, ,218 -38. ,087 1.00 20. 81 H C

ATOM 7330 CB LEU H 45 13. 550 -22. ,443 -39. ,383 1.00 17. 43 H C

ATOM 7333 CG LEU H 45 14. 633 -21. 370 -39. ,276 1.00 19. 51 H C

ATOM 7335 CDl LEU H 45 14. 816 -20. 667 -40. 590 1.00 13. 98 H c

ATOM 7339 CD2 LEU H 45 14. 293 -20. ,356 -38. 172 1.00 11. 48 H c

ATOM 7343 C LEU H 45 12. ,117 -24. ,117 -38. 163 1.00 24. 73 H c

ATOM 7344 O LEU H 45 12. ,117 -25. ,117 -38. ,881 1.00 18. 23 H 0

ATOM 7346 N GLU H 46 11.077 -23. ,778 -37. 389 1.00 25. 74 H N

ATOM 7347 CA GLU H 46 9. 801 -24. ,499 -37. ,446 1.00 24. 08 H c

ATOM 7349 CB GLU H 46 9. ,391 -25. 030 -36. 066 1.00 31. 02 H c

ATOM 7352 CG GLU H 46 10. ,488 -25. ,709 -35. 274 1.00 31.47 H c

ATOM 7355 CD GLU H 46 9. 956 -26. ,402 -34. 045 1.00 31. 32 H c

ATOM 7356 OEl GLU H 46 9. 406 -27. ,519 -34. 197 1.00 31. 09 H 0

ATOM 7357 OE2 GLU H 46 10. 083 -25. ,834 -32. 926 1.00 35. 35 H 0

ATOM 7358 C GLU H 46 8. ,709 -23. ,568 -37. 976 1.00 21. 65 H c

ATOM 7359 O GLU H 46 8. ,481 -22. ,493 -37. 429 1.00 17. 40 H 0

ATOM 7361 N TRP H 47 8. ,036 -23. ,986 -39. ,046 1.00 23. 74 H N

ATOM 7362 CA TRP H 47 6. 926 -23. ,223 -39. ,614 1.00 21. 45 H c

ATOM 7364 CB TRP H 47 6. ,734 -23. ,583 -41.080 1.00 21.53 H c

ATOM 7367 CG TRP H 47 6. ,060 -22. ,532 -41. 864 1.00 20. 32 H c

ATOM 7368 CDl TRP H 47 6. 642 -21. ,464 -42. 483 1.00 21.59 H c

ATOM 7370 NEl TRP H 47 5. 690 -20. ,724 -43. 136 1.00 23. 15 H N

ATOM 7372 CE2 TRP H 47 4. 465 -21. ,299 -42. 926 1.00 23. 37 H c

ATOM 7373 CD2 TRP H 47 4. ,664 -22. ,447 -42. 140 1.00 20. 67 H c

ATOM 7374 CE3 TRP H 47 3. ,561 -23. ,229 -41. ,794 1.00 19. 53 H c

ATOM 7376 CZ3 TRP H 47 2. 326 -22. ,851 -42. ,247 1.00 22. 17 H c

ATOM 7378 CH2 TRP H 47 2. ,162 -21. ,701 -43. 038 1.00 20. 89 H c

ATOM 7380 CZ2 TRP H 47 3. 212 -20. ,911 -43. 367 1.00 23. 65 H c

ATOM 7382 C TRP H 47 5. 647 -23. ,494 -38. 819 1.00 24. 29 H c

ATOM 7383 O TRP H 47 5. 116 -24. ,610 -38. 815 1.00 28. 46 H 0

ATOM 7385 N MET H 48 5. 162 -22. ,468 -38. 137 1.00 23. 62 H N

ATOM 7386 CA MET H 48 4. ,093 -22. ,646 -37. ,159 1.00 21.38 H c

ATOM 7388 CB MET H 48 4. ,180 -21. ,587 -36. ,074 1.00 22. 58 H c

ATOM 7391 CG MET H 48 5. 488 -21. ,571 -35. ,333 1.00 19. 63 H c

ATOM 7394 SD MET H 48 5. ,577 -20. ,232 -34. 132 1.00 20. 72 H s

ATOM 7395 CE MET H 48 3. 984 -20. .347 -33. ,283 1.00 12. 31 H c

ATOM 7399 C MET H 48 2. ,749 -22. ,554 -37. ,840 1.00 19. 36 H c

ATOM 7400 0 MET H 48 1. 873 -23. ,379 -37. ,608 1.00 25. 05 H 0

ATOM 7402 N GLY H 49 2. 589 -21. ,534 -38. 680 1.00 21. 93 H N

ATOM 7403 CA GLY H 49 1. 358 -21. ,359 -39. 418 1.00 24. 71 H c

ATOM 7406 C GLY H 49 1. ,284 -20. ,098 -40. ,244 1.00 26. ,87 H c

ATOM 7407 0 GLY H 49 2. ,285 -19. ,406 -40. ,445 1.00 21. ,71 H 0

ATOM 7409 N TRP H 50 0. ,059 -19. ,801 -40. 685 1.00 30. ,50 H N

ATOM 7410 CA TRP H 50 -0. ,256 -18. ,638 -41. 522 1.00 24. 26 H c

ATOM 7412 CB TRP H 50 -0. 321 -19. ,057 -43. 000 1.00 20. 38 H c

ATOM 7415 CG TRP H 50 -1. ,455 -18. ,532 -43. 842 1.00 22. 04 H c

ATOM 7416 CDl TRP H 50 -2. ,777 -18. ,915 -43. ,775 1.00 25. 29 H c

ATOM 7418 NEl TRP H 50 -3. ,508 -18. ,258 -44. ,735 1.00 25. 11 H N

ATOM 7420 CE2 TRP H 50 -2. ,678 -17. .435 -45. ,450 1.00 19. ,79 H c

ATOM 7421 CD2 TRP H 50 -1. ,376 -17. ,579 -44. ,923 1.00 22. ,68 H c

ATOM 7422 CE3 TRP H 50 -0. ,338 -16. ,830 -45. ,484 1.00 22. ,50 H c

ATOM 7424 CZ3 TRP H 50 -0. ,624 -15. ,987 -46. ,529 1.00 22. ,77 H c

ATOM 7426 CH2 TRP H 50 -1. 936 -15. ,850 -47. ,022 1.00 21. ,95 H c

ATOM 7428 CZ2 TRP H 50 -2. ,968 -16. ,566 -46. ,492 1.00 19. ,52 H c

ATOM 7430 C TRP H 50 -1. ,560 -17. ,994 -41. ,071 1.00 18. 83 H c

ATOM 7431 0 TRP H 50 -2. ,474 -18. ,678 -40. ,644 1.00 22. ,40 H 0

ATOM 7433 N ILE H 51 -1. ,615 -16. .667 -41. ,147 1.00 17. ,04 H N

ATOM 7434 CA ILE H 51 -2. ,874 -15, .956 -40. ,991 1.00 19. ,17 H c

ATOM 7436 CB ILE H 51 -2. ,930 -15. ,039 -39. ,739 1.00 16. 35 H c

ATOM 7438 CGI ILE H 51 -4. ,363 -14. ,472 -39. ,557 1.00 18. 38 H c

ATOM 7441 CDl ILE H 51 -4. ,785 -14. ,220 -38. ,133 1.00 13. ,32 H c

ATOM 7445 CG2 ILE H 51 -1. ,892 -13. ,920 -39. ,855 1.00 13. 56 H c cyno fD_Fab

ATOM 7449 C ILE H 51 -3 078 -15 149 -42 253 1.00 18 45 H C

ATOM 7450 O ILE H 51 -2. 139 -14 555 -42 795 1.00 18 62 H 0

ATOM 7452 N ASN H 52 -4 315 -15 177 -42 728 1.00 22 79 H N

ATOM 7453 CA ASN H 52 -4 746 -14 367 -43 838 1.00 22 85 H C

ATOM 7455 CB ASN H 52 -5 982 -14 997 -44 493 1.00 25 31 H C

ATOM 7458 CG ASN H 52 -6 297 -14 392 -45 847 1.00 24 08 H C

ATOM 7459 001 ASN H 52 -6 431 -13 179 -45 972 1.00 24 50 H 0

ATOM 7460 ND2 ASN H 52 -6. 438 -15 239 -46 863 1.00 22 24 H N

ATOM 7463 C ASN H 52 -5. 063 -12 989 -43 285 1.00 22 32 H C

ATOM 7464 O ASN H 52 -6. 002 -12 816 -42 500 1.00 18 42 H 0

ATOM 7466 N THR H 53 -4 274 -12 000 -43 673 1.00 20 16 H N

ATOM 7467 CA THR H 53 -4 508 -10 639 -43 188 1.00 20 19 H c

ATOM 7469 CB THR H 53 -3 327 -9 761 -43 530 1.00 17 32 H c

ATOM 7471 OGl THR H 53 -3. 031 -9 924 -44 915 1.00 15 86 H 0

ATOM 7473 CG2 THR H 53 -2. 117 -10 177 -42 691 1.00 16 93 H c

ATOM 7477 C THR H 53 -5. 805 -10 005 -43 728 1.00 22 94 H c

ATOM 7478 O THR H 53 -6. 332 -9 073 -43 124 1.00 20 07 H 0

ATOM 7480 N TYR H 54 -6 313 -10 530 -44 846 1.00 25 39 H N

ATOM 7481 CA TYR H 54 -7 495 -9 993 -45 518 1.00 25 81 H c

ATOM 7483 CB TYR H 54 -7 450 -10 262 -47 037 1.00 20 45 H c

ATOM 7486 CG TYR H 54 -8. 396 -9 359 -47 817 1.00 23 67 H c

ATOM 7487 CDl TYR H 54 -7. 922 -8 239 -48 510 1.00 21 14 H c

ATOM 7489 CEl TYR H 54 -8. 790 -7 398 -49 198 1.00 21 54 H c

ATOM 7491 CZ TYR H 54 -10. 153 -7 669 -49 186 1.00 20 89 H c

ATOM 7492 OH TYR H 54 -11. 023 -6 860 -49 876 1.00 20 50 H 0

ATOM 7494 CE2 TYR H 54 -10 643 -8 755 -48 492 1.00 19 32 H c

ATOM 7496 CD2 TYR H 54 -9 779 -9 584 -47 804 1.00 21 20 H c

ATOM 7498 C TYR H 54 -8. 786 -10 573 -44 964 1.00 24 04 H c

ATOM 7499 0 TYR H 54 -9. 732 -9 832 -44 705 1.00 29 33 H 0

ATOM 7501 N THR H 55 -8. 827 -11 895 -44 813 1.00 24 83 H N

ATOM 7502 CA THR H 55 -10. 036 -12 597 -44 372 1.00 25 12 H c

ATOM 7504 CB THR H 55 -10. 283 -13 853 -45 227 1.00 23 67 H c

ATOM 7506 OGl THR H 55 -9. 232 -14 781 -44 984 1.00 24 23 H 0

ATOM 7508 CG2 THR H 55 -10. 334 -13 525 -46 725 1.00 19 80 H c

ATOM 7512 C THR H 55 -9. 985 -13 060 -42 914 1.00 24 11 H c

ATOM 7513 0 THR H 55 -11. 027 -13 378 -42 332 1.00 18 81 H 0

ATOM 7515 N GLY H 56 -8. 788 -13 142 -42 333 1.00 25 62 H N

ATOM 7516 CA GLY H 56 -8. 631 -13 592 -40 939 1.00 26 35 H c

ATOM 7519 C GLY H 56 -8. 577 -15 099 -40 739 1.00 26 20 H c

ATOM 7520 0 GLY H 56 -8. 577 -15 589 -39 599 1.00 21 98 H 0

ATOM 7522 N GLU H 57 -8. 523 -15 840 -41 843 1.00 26 88 H N

ATOM 7523 CA GLU H 57 -8 382 -17 294 -41 801 1.00 30 37 H c

ATOM 7525 CB GLU H 57 -8 704 -17 895 -43 180 1.00 36 01 H c

ATOM 7528 CG GLU H 57 -10. 131 -17 667 -43 698 1.00 36 91 H c

ATOM 7531 CD GLU H 57 -10. 236 -17 915 -45 207 1.00 37 68 H c

ATOM 7532 OEl GLU H 57 -9. 777 -17 056 -45 987 1.00 38 05 H 0

ATOM 7533 OE2 GLU H 57 -10. 767 -18 971 -45 619 1.00 40 24 H 0

ATOM 7534 C GLU H 57 -6. 958 -17 733 -41 375 1.00 31 10 H c

ATOM 7535 0 GLU H 57 -5. 942 -17 099 -41 723 1.00 27 03 H 0

ATOM 7537 N THR H 58 -6 884 -18 851 -40 660 1.00 28 13 H N

ATOM 7538 CA THR H 58 -5 612 -19 350 -40 178 1.00 28 33 H c

ATOM 7540 CB THR H 58 -5 493 -19 084 -38 675 1.00 25 12 H c

ATOM 7542 OGl THR H 58 -6 554 -19 753 -37 993 1.00 25 52 H 0

ATOM 7544 CG2 THR H 58 -5. 579 -17 585 -38 392 1.00 19 47 H c

ATOM 7548 C THR H 58 -5. 444 -20 844 -40 436 1.00 29 10 H c

ATOM 7549 0 THR H 58 -6. 372 -21 623 -40 211 1.00 34 54 H 0

ATOM 7551 N THR H 59 -4. 260 -21 222 -40 911 1.00 24 53 H N

ATOM 7552 CA THR H 59 -3 818 -22 621 -40 964 1.00 26 92 H c

ATOM 7554 CB THR H 59 -3 363 -23 038 -42 382 1.00 24 01 H c

ATOM 7556 OGl THR H 59 -4 394 -22 739 -43 322 1.00 27 05 H 0

ATOM 7558 CG2 THR H 59 -3 086 -24 520 -42 446 1.00 18 89 H c

ATOM 7562 C THR H 59 -2 622 -22 820 -40 042 1.00 29 23 H c

ATOM 7563 0 THR H 59 -1 672 -22 039 -40 082 1.00 32 74 H 0

ATOM 7565 N TYR H 60 -2. 651 -23 879 -39 236 1.00 30 77 H N

ATOM 7566 CA TYR H 60 -1. 501 -24 235 -38 384 1.00 29 69 H c

ATOM 7568 CB TYR H 60 -1 952 -24 357 -36 932 1.00 26 89 H c

ATOM 7571 CG TYR H 60 -2 638 -23 123 -36 404 1.00 27 41 H c

ATOM 7572 CDl TYR H 60 -1 935 -22 161 -35 692 1.00 26 28 H c cyno fD_Fab

ATOM 7574 CE1 TYR H 60 -2. 578 -21. .029 -35. ,194 1.00 26. 66 H C

ATOM 7576 CZ TYR H 60 -3. 929 -20. ,843 -35. 432 1.00 26. 31 H C

ATOM 7577 OH TYR H 60 -4. 578 -19. ,715 -34. 959 1.00 25. 99 H 0

ATOM 7579 CE2 TYR H 60 -4. 643 -21. ,794 -36. 138 1.00 26. 28 H C

ATOM 7581 CD2 TYR H 60 -4. 004 -22. ,922 -36. 610 1.00 26. 38 H C

ATOM 7583 C TYR H 60 -0. 836 -25. ,541 -38. ,813 1.00 24. ,94 H C

ATOM 7584 O TYR H 60 -1. 515 -26. ,456 -39. ,251 1.00 28. 65 H 0

ATOM 7586 N ALA H 61 0. 488 -25. ,626 -38. ,685 1.00 22. 23 H N

ATOM 7587 CA ALA H 61 1. 179 -26. ,908 -38. ,813 1.00 23. 97 H C

ATOM 7589 CB ALA H 61 2. 695 -26. ,722 -38. ,848 1.00 20. 02 H C

ATOM 7593 C ALA H 61 0. 800 -27. ,778 -37. 634 1.00 24. 18 H c

ATOM 7594 O ALA H 61 0. 682 -27. ,272 -36. 529 1.00 22. 83 H 0

ATOM 7596 N ASP H 62 0. 662 -29. ,083 -37. 868 1.00 29. 72 H N

ATOM 7597 CA ASP H 62 0. 184 -30. ,034 -36. 853 1.00 30. 55 H c

ATOM 7599 CB ASP H 62 0. 423 -31. ,493 -37. ,279 1.00 36. 78 H c

ATOM 7602 CG ASP H 62 -0. 337 -31. 882 -38. ,542 1.00 42. 66 H c

ATOM 7603 ODl ASP H 62 0. 086 -32. 854 -39. 206 1.00 48. 86 H 0

ATOM 7604 002 ASP H 62 -1. 341 -31. 223 -38. 876 1.00 45. 60 H 0

ATOM 7605 C ASP H 62 0. 799 -29. ,828 -35. 473 1.00 33. 39 H c

ATOM 7606 0 ASP H 62 0. 086 -29. ,844 -34. 475 1.00 26. 25 H 0

ATOM 7608 N ASP H 63 2. 114 -29. ,630 -35. 412 1.00 34. 21 H N

ATOM 7609 CA ASP H 63 2. 799 -29. ,439 -34. ,114 1.00 33. 08 H c

ATOM 7611 CB ASP H 63 4. 321 -29. ,312 -34. ,312 1.00 36. 54 H c

ATOM 7614 CG ASP H 63 4. 973 -30. ,615 -34. ,723 1.00 39. 40 H c

ATOM 7615 ODl ASP H 63 4. 320 -31. ,677 -34. 627 1.00 42. 54 H 0

ATOM 7616 OD2 ASP H 63 6. 153 -30. ,574 -35. 142 1.00 43. 14 H 0

ATOM 7617 C ASP H 63 2. 320 -28. ,218 -33. 342 1.00 29. 06 H c

ATOM 7618 0 ASP H 63 2. 589 -28. ,117 -32. 142 1.00 35. 08 H 0

ATOM 7620 N PHE H 64 1. 651 -27. ,283 -34. 025 1.00 24. 95 H N

ATOM 7621 CA PHE H 64 1. 203 -26. ,025 -33. ,411 1.00 29. 59 H c

ATOM 7623 CB PHE H 64 1. 857 -24. ,841 -34. ,122 1.00 25. 55 H c

ATOM 7626 CG PHE H 64 3. 332 -24. ,797 -33. ,911 1.00 26. 64 H c

ATOM 7627 CDl PHE H 64 3. 843 -24. ,285 -32. ,734 1.00 25. 89 H c

ATOM 7629 CEl PHE H 64 5. 188 -24. ,286 -32. ,502 1.00 28. 03 H c

ATOM 7631 CZ PHE H 64 6. 056 -24. ,813 -33. ,454 1.00 22. 34 H c

ATOM 7633 CE2 PHE H 64 5. 561 -25. ,349 -34. 611 1.00 27. 49 H c

ATOM 7635 CD2 PHE H 64 4. 200 -25. ,353 -34. 833 1.00 26. 85 H c

ATOM 7637 C PHE H 64 -0. 308 -25. ,850 -33. 326 1.00 31. 84 H c

ATOM 7638 0 PHE H 64 -0. 800 -24. ,728 -33. ,241 1.00 32. 77 H 0

ATOM 7640 N LYS H 65 -1. 027 -26. ,970 -33. ,304 1.00 34. 72 H N

ATOM 7641 CA LYS H 65 -2. 479 -26. ,977 -33. ,141 1.00 33. 85 H c

ATOM 7643 CB LYS H 65 -3. 103 -28. ,113 -33. ,966 1.00 34. 04 H c

ATOM 7646 CG LYS H 65 -3. 149 -27. ,841 -35. ,455 1.00 32. 54 H c

ATOM 7649 CD LYS H 65 -3. 572 -29. ,075 -36. ,250 1.00 34. 58 H c

ATOM 7652 CE LYS H 65 -3. 723 -28. ,750 -37. ,749 1.00 36. 60 H c

ATOM 7655 NZ LYS H 65 -3. 539 -29. ,929 -38. ,656 1.00 33. ,54 H N

ATOM 7659 C LYS H 65 -2. 827 -27. ,163 -31. ,671 1.00 34. ,99 H c

ATOM 7660 0 LYS H 65 -2. 423 -28. ,147 -31. ,047 1.00 35. 09 H 0

ATOM 7662 N GLY H 66 -3. 576 -26. ,219 -31.115 1.00 35. 89 H N

ATOM 7663 CA GLY H 66 -4. Oil -26. ,318 -29. ,733 1.00 35. 07 H c

ATOM 7666 C GLY H 66 -3. 775 -25. ,042 -28. ,956 1.00 34. 11 H c

ATOM 7667 0 GLY H 66 -4. 719 -24. 303 -28. ,658 1.00 31. 70 H 0

ATOM 7669 N ARG H 67 -2. 511 -24. ,771 -28. ,646 1.00 33. 37 H N

ATOM 7670 CA ARG H 67 -2. 172 -23. ,708 -27. ,693 1.00 34. 72 H c

ATOM 7672 CB ARG H 67 -1. 004 -24. ,161 -26. ,816 1.00 35. ,74 H c

ATOM 7675 CG ARG H 67 -1. 395 -25. ,295 -25. ,870 1.00 38. ,35 H c

ATOM 7678 CD ARG H 67 -0. 288 -25. .688 -24, ,902 1.00 38. ,45 H c

ATOM 7681 NE ARG H 67 0. 951 -26. ,079 -25. ,581 1.00 38. 91 H N

ATOM 7683 CZ ARG H 67 2. 049 -25. ,327 -25. ,670 1.00 39. 41 H c

ATOM 7684 NHl ARG H 67 2. 096 -24. ,111 -25. 122 1.00 38. 90 H N

ATOM 7687 NH2 ARG H 67 3. 114 -25. ,801 -26. ,310 1.00 39. 58 H N

ATOM 7690 C ARG H 67 -1. 869 -22. .371 -28. ,354 1.00 32. 06 H c

ATOM 7691 0 ARG H 67 -1. 681 -21. ,363 -27. ,672 1.00 30. ,72 H 0

ATOM 7693 N PHE H 68 -1. 855 -22. .363 -29. ,682 1.00 31. ,26 H N

ATOM 7694 CA PHE H 68 -1. 384 -21. ,219 -30. ,450 1.00 33. ,08 H c

ATOM 7696 CB PHE H 68 -0. 285 -21. ,659 -31. ,418 1.00 31. ,68 H C

ATOM 7699 CG PHE H 68 0. 874 -22. ,365 -30. ,754 1.00 32. 76 H C

ATOM 7700 CDl PHE H 68 2. 080 -21. ,709 -30. ,547 1.00 34. 03 H C cyno fD_Fab

ATOM 7702 CEl PHE H 68 3. 148 -22. 356 -29. ,931 1.00 33. 41 H C

ATOM 7704 CZ PHE H 68 3. 019 -23. 672 -29. 523 1.00 30. 62 H C

ATOM 7706 CE2 PHE H 68 1. 825 -24. 339 -29. ,727 1.00 33. 43 H C

ATOM 7708 CD2 PHE H 68 0. 759 -23. 685 -30. 341 1.00 33. 54 H C

ATOM 7710 C PHE H 68 -2. 528 -20. 585 -31.236 1.00 34. 14 H C

ATOM 7711 O PHE H 68 -3. 262 -21. 282 -31. ,949 1.00 36. 64 H 0

ATOM 7713 N VAL H 69 -2. 654 -19. 263 -31. ,118 1.00 28. 53 H N

ATOM 7714 CA VAL H 69 -3. 685 -18. 512 -31. ,808 1.00 27. 57 H c

ATOM 7716 CB VAL H 69 -4. 795 -18. 102 -30. ,815 1.00 29. 40 H c

ATOM 7718 CGI VAL H 69 -5. 781 -17. 138 -31. ,453 1.00 29. 42 H c

ATOM 7722 CG2 VAL H 69 -5. 506 -19. 334 -30. 301 1.00 26. 52 H c

ATOM 7726 C VAL H 69 -3. 084 -17. 271 -32. 462 1.00 28. 71 H c

ATOM 7727 O VAL H 69 -2. 507 -16. 431 -31. ,782 1.00 37. 87 H 0

ATOM 7729 N PHE H 70 -3. 214 -17. 164 -33. ,779 1.00 20. 00 H N

ATOM 7730 CA PHE H 70 -2. 905 -15. 925 -34. ,502 1.00 23. 65 H c

ATOM 7732 CB PHE H 70 -2. 488 -16. 195 -35. ,968 1.00 21. 54 H c

ATOM 7735 CG PHE H 70 -1. 537 -17. 309 -36. ,134 1.00 25. 31 H c

ATOM 7736 CDl PHE H 70 -0. 509 -17. 520 -35. 219 1.00 24. 70 H c

ATOM 7738 CEl PHE H 70 0. 384 -18. 565 -35. ,402 1.00 24. 33 H c

ATOM 7740 CZ PHE H 70 0. 252 -19. 393 -36. ,502 1.00 21. 33 H c

ATOM 7742 CE2 PHE H 70 -0. 762 -19. 180 -37. ,418 1.00 21. 21 H c

ATOM 7744 CD2 PHE H 70 -1. 631 -18. 148 -37. ,250 1.00 26. 15 H c

ATOM 7746 C PHE H 70 -4. 132 -15. 029 -34. ,530 1.00 26. 86 H c

ATOM 7747 0 PHE H 70 -5. 247 -15. 520 -34. ,715 1.00 30. 76 H 0

ATOM 7749 N SER H 71 -3. 922 -13. 724 -34. ,344 1.00 29. 42 H N

ATOM 7750 CA SER H 71 -4. 977 -12. 726 -34. ,425 1.00 24. 86 H c

ATOM 7752 CB SER H 71 -5. 467 -12. 338 -33. ,030 1.00 29. 42 H c

ATOM 7755 OG SER H 71 -4. 532 -11. 555 -32. ,302 1.00 27. 89 H 0

ATOM 7757 C SER H 71 -4. 481 -11. 512 -35. ,206 1.00 26. 32 H c

ATOM 7758 0 SER H 71 -3. 320 -11. 453 -35. ,624 1.00 27. 03 H 0

ATOM 7760 N LEU H 72 -5. 370 -10. 553 -35. ,439 1.00 27. 76 H N

ATOM 7761 CA LEU H 72 -5. Oil -9. 349 -36. ,187 1.00 26. 98 H c

ATOM 7763 CB LEU H 72 -5. 560 -9. 412 -37. ,613 1.00 25. 65 H c

ATOM 7766 CG LEU H 72 -5. 125 -10. 492 -38. ,591 1.00 26. 00 H c

ATOM 7768 CDl LEU H 72 -6. 125 -10. 581 -39. ,730 1.00 25. 54 H c

ATOM 7772 CD2 LEU H 72 -3. 712 -10. 247 -39. ,131 1.00 25. 52 H c

ATOM 7776 C LEU H 72 -5. 563 -8. 093 -35. ,534 1.00 29. 78 H c

ATOM 7777 0 LEU H 72 -6. 494 -8. 151 -34. ,731 1.00 30. 42 H 0

ATOM 7779 N ASP H 73 -4. 951 -6. 961 -35. ,870 1.00 29. 04 H N

ATOM 7780 CA ASP H 73 -5. 595 -5. 661 -35. ,752 1.00 26. 85 H c

ATOM 7782 CB ASP H 73 -5. 189 -4. 901 -34. ,474 1.00 26. 53 H c

ATOM 7785 CG ASP H 73 -6. 038 -3. 652 -34. 242 1.00 29. 22 H c

ATOM 7786 ODl ASP H 73 -6. 648 -3. 168 -35. ,225 1.00 24. 50 H 0

ATOM 7787 OD2 ASP H 73 -6. 102 -3. 156 -33. 084 1.00 28. 46 H 0

ATOM 7788 C ASP H 73 -5. 227 -4. 903 -37. 028 1.00 25. 01 H c

ATOM 7789 0 ASP H 73 -4. 163 -4. 288 -37. ,137 1.00 26. 61 H 0

ATOM 7791 N THR H 74 -6. 116 -5. 013 -38. ,005 1.00 26. 98 H N

ATOM 7792 CA THR H 74 -5. 948 -4. 412 -39. ,328 1.00 31. 65 H c

ATOM 7794 CB THR H 74 -7. 112 -4. 848 -40. ,263 1.00 33. 32 H c

ATOM 7796 OGl THR H 74 -6. 599 -5. 709 -41.287 1.00 35. 29 H 0

ATOM 7798 CG2 THR H 74 -7. 801 -3. 658 -40. ,902 1.00 37. 45 H c

ATOM 7802 C THR H 74 -5. 833 -2. 882 -39. ,291 1.00 34. 76 H c

ATOM 7803 0 THR H 74 -5. 165 -2. 291 -40. .141 1.00 35. 38 H 0

ATOM 7805 N SER H 75 -6. 468 -2. 259 -38. .296 1.00 32. 35 H N

ATOM 7806 CA SER H 75 -6. 448 -0. 804 -38. ,128 1.00 33. 79 H c

ATOM 7808 CB SER H 75 -7. 464 -0. 394 -37. ,063 1.00 34. 77 H c

ATOM 7811 OG SER H 75 -7. 111 -0. 944 -35. ,807 1.00 34. 63 H 0

ATOM 7813 C SER H 75 -5. 081 -0. 238 -37. ,737 1.00 34. 99 H c

ATOM 7814 0 SER H 75 -4. 862 0. 967 -37. ,838 1.00 34. 06 H 0

ATOM 7816 N VAL H 76 -4. 181 -1. 099 -37. ,259 1.00 36. 77 H N

ATOM 7817 CA VAL H 76 -2. 827 -0. 687 -36. ,896 1.00 32. 83 H c

ATOM 7819 CB VAL H 76 -2. 678 -0. 593 -35. ,329 1.00 34. 68 H c

ATOM 7821 CGI VAL H 76 -2. 899 -1. 946 -34. ,657 1.00 30. 49 H c

ATOM 7825 CG2 VAL H 76 -1. 334 0. 012 -34. ,933 1.00 36. 70 H c

ATOM 7829 C VAL H 76 -1. 781 -1. 598 -37. ,554 1.00 34. 93 H c

ATOM 7830 0 VAL H 76 -0. 633 -1. 661 -37, ,106 1.00 35. 98 H 0

ATOM 7832 N SER H 77 -2. 186 -2. 269 -38. ,640 1.00 30. 14 H N

ATOM 7833 CA SER H 77 -1. 327 -3. 139 -39. .441 1.00 29. 12 H C cyno fo_Fab

ATOM 7835 CB SER H 77 -0. 485 -2. 307 -40. 421 1.00 30. 46 H C

ATOM 7838 OG SER H 77 -1. 313 -1. 711 -41. 407 1.00 29. 38 H 0

ATOM 7840 C SER H 77 -0. 444 -4. ,092 -38. 620 1.00 24. 19 H c

ATOM 7841 O SER H 77 0. 749 -4. 217 -38. 877 1.00 30. 85 H 0

ATOM 7843 N THR H 78 -1. 066 -4. 799 -37. 679 1.00 22. 85 H N

ATOM 7844 CA THR H 78 -0. 361 -5. 623 -36. 707 1.00 23. 30 H c

ATOM 7846 CB THR H 78 -0. 455 -4. 983 -35. 321 1.00 25. 09 H c

ATOM 7848 OGl THR H 78 0. 059 -3. 648 -35. 389 1.00 23. 52 H 0

ATOM 7850 CG2 THR H 78 0. 330 -5. 787 -34. 276 1.00 21. 29 H c

ATOM 7854 C THR H 78 -0. 885 -7. 065 -36. 636 1.00 24. 37 H c

ATOM 7855 O THR H 78 -2. 083 -7. 298 -36. 529 1.00 25. 74 H 0

ATOM 7857 N ALA H 79 0. 042 -8. 022 -36. 702 1.00 26. 34 H N

ATOM 7858 CA ALA H 79 -0. 245 -9. 440 -36. 473 1.00 23. 73 H c

ATOM 7860 CB ALA H 79 0. 473 -10. 276 -37. ,484 1.00 22. 08 H c

ATOM 7864 C ALA H 79 0. 175 -9. 831 -35. 053 1.00 20. 53 H c

ATOM 7865 O ALA H 79 1. 174 -9. 343 -34. 544 1.00 22. 24 H 0

ATOM 7867 N TYR H 80 -0. 614 -10. 684 -34. 408 1.00 23. 67 H N

ATOM 7868 CA TYR H 80 -0. 349 -11. 111 -33. 038 1.00 25. 45 H c

ATOM 7870 CB TYR H 80 -1. 427 -10. 602 -32. 062 1.00 29. 91 H C

ATOM 7873 CG TYR H 80 -1. 599 -9. 099 -32. 054 1.00 30. 58 H c

ATOM 7874 CDl TYR H 80 -0. 927 -8. 298 -31. 124 1.00 30. 74 H c

ATOM 7876 CEl TYR H 80 -1. 082 -6. 911 -31. 126 1.00 30. 71 H c

ATOM 7878 CZ TYR H 80 -1. 915 -6. 318 -32. 065 1.00 30. 99 H c

ATOM 7879 OH TYR H 80 -2. 077 -4. 952 -32. 094 1.00 31. 41 H 0

ATOM 7881 CE2 TYR H 80 -2. 584 -7. 098 -32. 996 1.00 31. 37 H c

ATOM 7883 CD2 TYR H 80 -2. 428 -8. 474 -32. 981 1.00 30. 50 H c

ATOM 7885 C TYR H 80 -0. 284 -12. 629 -32. 960 1.00 25. 34 H c

ATOM 7886 O TYR H 80 -1. 025 -13. 324 -33. 646 1.00 27. 64 H 0

ATOM 7888 N LEU H 81 0. 637 -13. 126 -32. 133 1.00 27. 47 H N

ATOM 7889 CA LEU H 81 0. 715 -14. 532 -31. 751 1.00 23. 83 H c

ATOM 7891 CB LEU H 81 2. 101 -15. 098 -32. 060 1.00 26. 44 H c

ATOM 7894 CG LEU H 81 2. 456 -16. 504 -31. 551 1.00 24. 85 H c

ATOM 7896 CDl LEU H 81 1. 578 -17. 592 -32. 203 1.00 16. 74 H c

ATOM 7900 CD2 LEU H 81 3. 931 -16. 758 -31. 775 1.00 18. 19 H c

ATOM 7904 C LEU H 81 0. 440 -14. 576 -30. 264 1.00 28. 02 H c

ATOM 7905 O LEU H 81 1. 071 -13. 867 -29. 489 1.00 25. 39 H 0

ATOM 7907 N GLN H 82 -0. 547 -15. 374 -29. 884 1.00 29. 78 H N

ATOM 7908 CA GLN H 82 -0. 836 -15. 643 -28. 501 1.00 28. 43 H c

ATOM 7910 CB GLN H 82 -2. 273 -15. 248 -28. 175 1.00 30. 83 H c

ATOM 7913 CG GLN H 82 -2. 696 -15. 577 -26. 751 1.00 34. 26 H c

ATOM 7916 CD GLN H 82 -3. 715 -14. 612 -26. 192 1.00 35. 39 H c

ATOM 7917 OEl GLN H 82 -4. 453 -13. 955 -26. 936 1.00 38. 91 H 0

ATOM 7918 NE2 GLN H 82 -3. 751 -14. 506 -24. 868 1.00 37. 56 H N

ATOM 7921 C GLN H 82 -0. 603 -17. 126 -28. 267 1.00 28. 40 H c

ATOM 7922 O GLN H 82 -1. 162 -17. 960 -28. 976 1.00 33. 56 H 0

ATOM 7924 N ILE H 83 0. 263 -17. 441 -27. 303 1.00 27. 74 H N

ATOM 7925 CA ILE H 83 0. 572 -18. ,820 -26. 920 1.00 27. 63 H c

ATOM 7927 CB ILE H 83 2. 095 -19. ,071 -26. ,851 1.00 24. ,57 H c

ATOM 7929 CGI ILE H 83 2. 766 -18. ,679 -28. 175 1.00 24. 23 H c

ATOM 7932 CDl ILE H 83 4. 277 -18. ,740 -28. ,147 1.00 26. 68 H c

ATOM 7936 CG2 ILE H 83 2. 376 -20. ,521 -26. 507 1.00 24. 12 H c

ATOM 7940 C ILE H 83 -0. 028 -19. ,006 -25. 541 1.00 29. 51 H c

ATOM 7941 O ILE H 83 0. 241 -18. 194 -24. 657 1.00 33. 13 H 0

ATOM 7943 N SER H 84 -0. 844 -20. 051 -25. 364 1.00 30. 58 H N

ATOM 7944 CA SER H 84 -1. 512 -20. 334 -24. 080 1.00 32. 14 H c

ATOM 7946 CB SER H 84 -3. 016 -20. ,527 -24. ,284 1.00 32. ,52 H c

ATOM 7949 OG SER H 84 -3. 659 -19. ,271 -24. 366 1.00 36. ,26 H 0

ATOM 7951 C SER H 84 -0. 938 -21. ,551 -23. ,364 1.00 30. ,87 H c

ATOM 7952 O SER H 84 -0. 371 -22. 435 -23. 992 1.00 31. ,03 H 0

ATOM 7954 N SER H 85 -1. 130 -21. 582 -22. 044 1.00 34. ,35 H N

ATOM 7955 CA SER H 85 -0. 602 -22. 637 -21. 159 1.00 34. ,09 H c

ATOM 7957 CB SER H 85 -1. 422 -23. ,925 -21. 297 1.00 34. ,24 H c

ATOM 7960 OG SER H 85 -2. 705 -23. ,727 -20. 732 1.00 37. ,26 H 0

ATOM 7962 C SER H 85 0. 895 -22. 898 -21. 375 1.00 28. ,97 H c

ATOM 7963 O SER H 85 1. 308 -24. 040 -21. ,589 1.00 30. ,16 H 0

ATOM 7965 N LEU H 86 1. 681 -21. 823 -21.260 1.00 22. ,60 H N

ATOM 7966 CA LEU H 86 3. 116 -21. ,814 -21. ,578 1.00 32. ,94 H c

ATOM 7968 CB LEU H 86 3. 754 -20. ,469 -21. ,176 1.00 29. ,80 H c cyno fD_Fab

ATOM 7971 CG LEU H 86 3. 938 -19. .446 -22. 312 1.00 28. ,47 H C

ATOM 7973 CDl LEU H 86 2. 980 -19. ,686 -23. 468 1.00 31. ,08 H C

ATOM 7977 CD2 LEU H 86 3. 818 -18. ,012 -21. 827 1.00 28. ,39 H C

ATOM 7981 C LEU H 86 3. 911 -22. ,967 -20. 976 1.00 34. ,29 H C

ATOM 7982 O LEU H 86 3. 667 -23. ,368 -19. 848 1.00 25. ,73 H 0

ATOM 7984 N LYS H 87 4. 850 -23. ,500 -21. 757 1.00 32. 06 H N

ATOM 7985 CA LYS H 87 5. ,719 -24. ,585 -21.303 1.00 37. ,94 H C

ATOM 7987 CB LYS H 87 5. 423 -25. ,855 -22. 106 1.00 43. 35 H C

ATOM 7990 CG LYS H 87 4. 077 -26. ,520 -21. 790 1.00 45. 90 H c

ATOM 7993 CD LYS H 87 3. 521 -27. ,306 -22. 994 1.00 45. ,57 H c

ATOM 7996 CE LYS H 87 4. 511 -28. ,327 -23. 578 1.00 47. 22 H c

ATOM 7999 NZ LYS H 87 4. 844 -29. ,430 -22. 627 1.00 50. ,73 H N

ATOM 8003 C LYS H 87 7. 186 -24.194 -21. 480 1.00 37. 32 H c

ATOM 8004 O LYS H 87 7. 498 -23. ,305 -22. 265 1.00 41. 73 H 0

ATOM 8006 N ALA H 88 8. 083 -24. ,868 -20. 763 1.00 36. 49 H N

ATOM 8007 CA ALA H 88 9. 522 -24. ,584 -20. 850 1.00 33. ,56 H c

ATOM 8009 CB ALA H 88 10. 286 -25. ,472 -19. 896 1.00 29. ,59 H c

ATOM 8013 C ALA H 88 10. 057 -24. ,744 -22. 282 1.00 35. ,50 H c

ATOM 8014 O ALA H 88 10. 938 -23. ,990 -22. 717 1.00 32. ,47 H 0

ATOM 8016 N GLU H 89 9. 490 -25. ,705 -23. 012 1.00 36. ,02 H N

ATOM 8017 CA GLU H 89 9. 877 -25. 999 -24. 406 1.00 34. ,85 H c

ATOM 8019 CB GLU H 89 9. 394 -27. ,388 -24. 865 1.00 40. ,24 H c

ATOM 8022 CG GLU H 89 8. 329 -28. ,073 -23. 995 1.00 42. 76 H c

ATOM 8025 CD GLU H 89 8. 891 -28. ,615 -22. 687 1.00 46. 41 H c

ATOM 8026 OEl GLU H 89 8. 148 -28. ,613 -21. 674 1.00 44.25 H 0

ATOM 8027 OE2 GLU H 89 10. 078 -29. ,025 -22. 668 1.00 47. ,20 H 0

ATOM 8028 C GLU H 89 9. 422 -24. ,930 -25. 406 1.00 31. ,29 H c

ATOM 8029 O GLU H 89 9. 911 -24. .888 -26. 530 1.00 33. ,83 H 0

ATOM 8031 N ASP H 90 8. 497 -24. ,068 -24. 995 1.00 30. ,11 H N

ATOM 8032 CA ASP H 90 8. 141 -22. ,888 -25. 789 1.00 28. ,57 H c

ATOM 8034 CB ASP H 90 6. 783 -22. ,359 -25. 377 1.00 28. ,15 H c

ATOM 8037 CG ASP H 90 5. 706 -23. ,378 -25. 563 1.00 25. 63 H c

ATOM 8038 ODl ASP H 90 5. 786 -24. ,151 -26. 549 1.00 6. 66 H 0

ATOM 8039 OD2 ASP H 90 4. 795 -23. ,412 -24. 717 1.00 2. ,00 H 0

ATOM 8040 C ASP H 90 9. 142 -21. ,750 -25. 695 1.00 28. ,95 H c

ATOM 8041 O ASP H 90 8. 898 -20. ,673 -26. 247 1.00 36. ,03 H 0

ATOM 8043 N THR H 91 10. 246 -21. ,964 -24. 985 1.00 26. ,59 H N

ATOM 8044 CA THR H 91 11. 308 -20. ,980 -24. 937 1.00 24. ,21 H c

ATOM 8046 CB THR H 91 12. 339 -21. ,303 -23. 845 1.00 22. ,44 H c

ATOM 8048 OGl THR H 91 11. 709 -21. ,251 -22. 553 1.00 26. ,55 H 0

ATOM 8050 CG2 THR H 91 13. 511 -20. ,309 -23. 909 1.00 23. ,69 H c

ATOM 8054 C THR H 91 11. 939 -21. ,007 -26. 326 1.00 22. ,91 H c

ATOM 8055 0 THR H 91 12. 536 -22. ,003 -26. ,703 1.00 23. ,54 H 0

ATOM 8057 N ALA H 92 11. 734 -19. ,935 -27. ,088 1.00 21. ,73 H N

ATOM 8058 CA ALA H 92 12. 217 -19. ,849 -28. 475 1.00 24. 07 H c

ATOM 8060 CB ALA H 92 11. 421 -20. ,776 -29. 367 1.00 14. 67 H c

ATOM 8064 C ALA H 92 12. 085 -18. ,419 -28. 995 1.00 25. ,06 H c

ATOM 8065 0 ALA H 92 11. 316 -17. ,612 -28. 455 1.00 28. 86 H 0

ATOM 8067 N VAL H 93 12. 847 -18. ,114 -30. 034 1.00 28. 61 H N

ATOM 8068 CA VAL H 93 12. 578 -16. ,929 -30. 830 1.00 25. 63 H c

ATOM 8070 CB VAL H 93 13. 769 -16. ,482 -31. 660 1.00 18. 28 H c

ATOM 8072 CGI VAL H 93 13. 443 -15. .175 -32. 350 1.00 9. ,83 H c

ATOM 8076 CG2 VAL H 93 14. 993 -16. .317 -30. ,775 1.00 18. ,78 H c

ATOM 8080 C VAL H 93 11. 403 -17. ,239 -31. ,751 1.00 24. ,01 H c

ATOM 8081 0 VAL H 93 11. 335 -18. ,316 -32. ,338 1.00 20. ,21 H 0

ATOM 8083 N TYR H 94 10. 468 -16. ,294 -31. ,798 1.00 25. ,45 H N

ATOM 8084 CA TYR H 94 9. 279 -16. ,332 -32. ,627 1.00 22. ,08 H C

ATOM 8086 CB TYR H 94 8. 031 -16, ,119 -31. ,747 1.00 19. 33 H C

ATOM 8089 CG TYR H 94 7. 781 -17. ,302 -30. 864 1.00 16. ,65 H c

ATOM 8090 CDl TYR H 94 7. 088 -18. ,400 -31.349 1.00 18. ,77 H c

ATOM 8092 CEl TYR H 94 6. 884 -19. .527 -30. ,576 1.00 18. ,65 H c

ATOM 8094 CZ TYR H 94 7. 369 -19. .570 -29. ,295 1.00 17. ,90 H c

ATOM 8095 OH TYR H 94 7. 156 -20. .710 -28. ,562 1.00 19. ,11 H 0

ATOM 8097 CE2 TYR H 94 8. 087 -18. .488 -28. ,773 1.00 18. ,42 H c

ATOM 8099 CD2 TYR H 94 8. 295 -17. ,365 -29. ,566 1.00 20. ,37 H c

ATOM 8101 C TYR H 94 9. 417 -15. ,205 -33. ,637 1.00 22. ,15 H c

ATOM 8102 0 TYR H 94 9. 566 -14. ,050 -33. ,259 1.00 26. ,25 H 0

ATOM 8104 N TYR H 95 9. 388 -15. ,550 -34. ,917 1.00 24.17 H N cyno fD_Fab

ATOM 8105 CA TYR H 95 9. ,444 -14. ,575 -36. ,000 1. 00 24. ,88 H C

ATOM 8107 CB TYR H 95 10. ,419 -15. ,025 -37. ,068 1. 00 24. 21 H C

ATOM 8110 CG TYR H 95 11. ,872 -15. ,137 -36. ,687 1. 00 27. 68 H C

ATOM 8111 CDl TYR H 95 12. ,701 -14. ,024 -36. ,746 1. 00 29. ,70 H C

ATOM 8113 CEl TYR H 95 14. ,054 -14. ,119 -36. ,468 1. 00 27. ,47 H C

ATOM 8115 CZ TYR H 95 14. ,592 -15. ,334 -36, ,133 1. 00 25. ,18 H c

ATOM 8116 OH TYR H 95 15. ,923 -15. ,377 -35. ,853 1. 00 26. ,94 H 0

ATOM 8118 CE2 TYR H 95 13. ,799 -16. ,474 -36. 075 1. 00 23. 47 H c

ATOM 8120 CD2 TYR H 95 12. ,447 -16. ,373 -36. 369 1. 00 23. 66 H c

ATOM 8122 C TYR H 95 8. ,107 -14. ,451 -36. 720 1. 00 27. 83 H c

ATOM 8123 O TYR H 95 7. ,320 -15. ,401 -36. 776 1. 00 28. 13 H 0

ATOM 8125 N CYS H 96 7. 882 -13. ,282 -37. ,311 1. 00 28. 29 H N

ATOM 8126 CA CYS H 96 6. ,873 -13, ,133 -38. ,351 1. 00 27. ,75 H c

ATOM 8128 CB CYS H 96 5. ,953 -11. ,955 -38. ,049 1. 00 29. 00 H c

ATOM 8131 SG CYS H 96 6. 759 -10. ,339 -37. 808 1. 00 28. 42 H s

ATOM 8133 C CYS H 96 7. ,596 -12. 927 -39. ,672 1. 00 23. 39 H c

ATOM 8134 O CYS H 96 8. 631 -12. ,269 -39. ,691 1. 00 22. 91 H 0

ATOM 8136 N GLU H 97 7. 088 -13. ,527 -40. ,749 1. 00 24. 86 H N

ATOM 8137 CA GLU H 97 7. 499 -13. ,146 -42. ,110 1. 00 28. 71 H c

ATOM 8139 CB GLU H 97 8. ,492 -14. ,120 -42. ,801 1. 00 28. 02 H c

ATOM 8142 CG GLU H 97 8. 072 -15. ,550 -42. ,863 1. 00 30. ,58 H c

ATOM 8145 CD GLU H 97 8. ,371 -16. ,258 -44. ,205 1. 00 28. 90 H c

ATOM 8146 OEl GLU H 97 9. 353 -15. ,977 -44. ,942 1. 00 26. 45 H 0

ATOM 8147 OE2 GLU H 97 7. 578 -17. ,146 -44. ,515 1. 00 33. 22 H 0

ATOM 8148 C GLU H 97 6. 303 -12. ,931 -43. ,004 1. 00 26. 95 H c

ATOM 8149 O GLU H 97 5. 275 -13. ,619 -42. ,911 1. 00 28. 62 H 0

ATOM 8151 N ARG H 98 6. ,459 -11. ,958 -43. .885 1. 00 25. 24 H N

ATOM 8152 CA ARG H 98 5. 380 -11. ,568 -44. ,755 1. 00 26. 03 H c

ATOM 8154 CB ARG H 98 5. 588 -10. ,135 -45. ,268 1. 00 19. ,72 H c

ATOM 8157 CG ARG H 98 4. 460 -9. ,687 -46. ,156 1. 00 23. 64 H c

ATOM 8160 CD ARG H 98 4. 737 -8. ,400 -46. ,870 1. 00 24. 21 H c

ATOM 8163 NE ARG H 98 5. 776 -8. ,516 -47. ,882 1. 00 23. 55 H N

ATOM 8165 CZ ARG H 98 6. 033 -7. ,588 -48. ,796 1. 00 26. 06 H c

ATOM 8166 NHl ARG H 98 5. 322 -6. ,461 -48. ,839 1. 00 25. 80 H N

ATOM 8169 NH2 ARG H 98 7. 007 -7. ,778 -49. ,670 1. 00 24. ,64 H N

ATOM 8172 C ARG H 98 5. 375 -12. ,590 -45. ,882 1. 00 25. ,96 H C

ATOM 8173 O ARG H 98 6. 432 -12. ,892 -46. 428 1. 00 19. ,43 H 0

ATOM 8175 N GLU H 99 4. 199 -13. ,146 -46. 180 1. 00 24. 19 H N

ATOM 8176 CA GLU H 99 3. 993 -14. ,056 -47. ,314 1. 00 25. 74 H C

ATOM 8178 CB GLU H 99 2. 913 -15. ,053 -46. 896 1. 00 25. 41 H c

ATOM 8181 CG GLU H 99 2. 658 -16. ,148 -47. ,897 1. 00 26. 70 H c

ATOM 8184 CD GLU H 99 3. 901 -16. ,907 -48. ,290 1. 00 26. ,55 H c

ATOM 8185 OEl GLU H 99 4. ,844 -16. ,951 -47. ,485 1. 00 25. ,94 H 0

ATOM 8186 OE2 GLU H 99 3. 926 -17. ,477 -49. ,396 1. 00 20. ,58 H 0

ATOM 8187 C GLU H 99 3. ,520 -13. ,166 -48. ,461 1. 00 26. ,84 H c

ATOM 8188 O GLU H 99 2. 323 -12. ,940 -48. ,624 1. 00 32. ,10 H 0

ATOM 8190 N GLY H 100 4. 403 -12. ,620 -49. ,285 1. 00 33. ,16 H N

ATOM 8191 CA GLY H 100 5. 128 -13. ,282 -50. ,386 1. 00 22. ,73 H c

ATOM 8194 C GLY H 100 5. ,721 -11. ,963 -50. ,904 1. 00 22. ,89 H c

ATOM 8195 O GLY H 100 6. 007 -11. ,080 -50. ,090 1. 00 23. 35 H 0

ATOM 8197 N GLY H 101 5. 898 -11. ,758 -52. ,203 1. 00 25. ,39 H N

ATOM 8198 CA GLY H 101 6. 686 -10. ,601 -52. ,665 1. 00 27. ,71 H c

ATOM 8201 C GLY H 101 8. ,165 -10. ,701 -52. ,249 1. 00 33. ,17 H c

ATOM 8202 O GLY H 101 8. ,648 -11. ,799 -51. ,922 1. 00 30. ,77 H 0

ATOM 8204 N VAL H 108 8. 882 -9. ,567 -52. ,282 1. 00 30. 83 H N

ATOM 8205 CA VAL H 108 10. ,258 -9. ,468 -51. .775 1. 00 27. ,55 H c

ATOM 8207 CB VAL H 108 10. ,829 -8. ,011 -51. .914 1. 00 27. ,41 H c

ATOM 8209 CGI VAL H 108 12. ,227 -7. .873 -51.289 1. 00 17. ,94 H c

ATOM 8213 CG2 VAL H 108 10. ,882 -7. ,599 -53. ,385 1. 00 28. ,02 H c

ATOM 8217 C VAL H 108 10. ,205 -9. ,894 -50. ,316 1. 00 32. ,10 H c

ATOM 8218 O VAL H 108 9. ,407 -9. ,360 -49. ,551 1. 00 33. 42 H 0

ATOM 8220 N ASN H 109 11. ,032 -10. ,872 -49. ,937 1. 00 31. 28 H N

ATOM 8221 CA ASN H 109 10. 868 -11. ,548 -48. ,648 1. 00 27. ,01 H c

ATOM 8223 CB ASN H 109 11. ,589 -12. .902 -48, ,676 1. 00 26. ,72 H C

ATOM 8226 CG ASN H 109 11. ,203 -13. .812 -47. .519 1. 00 24. ,94 H c

ATOM 8227 ODl ASN H 109 10. ,090 -14, ,318 -47. .456 1. ,00 26. ,44 H 0

ATOM 8228 ND2 ASN H 109 12. ,142 -14. .060 -46. ,630 1. 00 25. ,17 H N

ATOM 8231 C ASN H 109 11. ,331 -10, ,710 -47. ,452 1. 00 26. ,64 H c cyno fD_Fab

ATOM 8232 O ASN H 109 12.497 -10. ,318 -47. 361 1.00 24. ,08 H 0

ATOM 8234 N ASN H 110 10.395 -10. ,441 -46. 542 1.00 26. ,69 H N

ATOM 8235 CA ASN H 110 10.681 -9. ,710 -45. 323 1.00 28. ,03 H C

ATOM 8237 CB ASN H 110 9.995 -8. ,342 -45. 320 1.00 27. ,80 H C

ATOM 8240 CG ASN H 110 10.616 -7. ,379 -46. 301 1.00 27. ,42 H C

ATOM 8241 ODl ASN H 110 11.457 -6. ,566 -45. 934 1.00 32. ,21 H 0

ATOM 8242 ND2 ASN H 110 10.204 -7. ,464 -47. 555 1.00 22. ,21 H N

ATOM 8245 C ASN H 110 10.287 -10. ,482 -44. 074 1.00 26. ,90 H c

ATOM 8246 O ASN H 110 9.257 -11. 158 -44. 034 1.00 27. 05 H 0

ATOM 8248 N TRP H 111 11.139 -10. 355 -43. 063 1.00 27. 87 H N

ATOM 8249 CA TRP H 111 10.959 -10.970 -41. 764 1.00 28. ,11 H C

ATOM 8251 CB TRP H 111 12.104 -11. 936 -41.497 1.00 24. ,76 H c

ATOM 8254 CG TRP H 111 12.001 -13. ,247 -42. 198 1.00 20. ,76 H c

ATOM 8255 CDl TRP H 111 11.996 -13. ,469 -43. 543 1.00 23. ,07 H c

ATOM 8257 NEl TRP H 111 11.905 -14. ,812 -43. 799 1.00 24. ,95 H N

ATOM 8259 CE2 TRP H 111 11.841 -15. ,485 -42. 612 1.00 20. ,80 H c

ATOM 8260 CD2 TRP H 111 11.908 -14. ,526 -41. 580 1.00 16. ,55 H c

ATOM 8261 CE3 TRP H 111 11.889 -14. ,958 -40. 250 1.00 21. ,08 H c

ATOM 8263 CZ3 TRP H 111 11.799 -16. ,313 -40. 000 l.oo 23. ,79 H c

ATOM 8265 CH2 TRP H 111 11.751 -17. 253 -41. 060 1.00 23. ,87 H c

ATOM 8267 CZ2 TRP H 111 11.756 -16. ,855 -42. 362 1.00 22. ,29 H c

ATOM 8269 C TRP H 111 11.000 -9. ,892 -40. 692 1.00 28. ,71 H c

ATOM 8270 O TRP H 111 11.654 -8. ,862 -40. 856 1.00 27. ,45 H 0

ATOM 8272 N GLY H 112 10.321 -10. ,149 -39. 582 1.00 26. ,40 H N

ATOM 8273 CA GLY H 112 10.537 -9. ,381 -38. 382 1.00 26. ,14 H c

ATOM 8276 C GLY H 112 11.850 -9. 791 -37. 740 1.00 23. ,03 H c

ATOM 8277 O GLY H 112 12.415 -10. ,796 -38. 102 1.00 26. ,04 H 0

ATOM 8279 N GLN H 113 12.301 -9. 019 -36. 753 1.00 29. ,04 H N

ATOM 8280 CA GLN H 113 13.587 -9. 258 -36. 080 1.00 28. ,04 H c

ATOM 8282 CB GLN H 113 14.095 -7. ,966 -35. 379 1.00 26. ,51 H c

ATOM 8285 CG GLN H 113 13.579 -7. ,666 -33. 949 1.00 26. ,20 H c

ATOM 8288 CD GLN H 113 12.229 -6. 976 -33. 914 1.00 26. ,07 H C

ATOM 8289 OEl GLN H 113 11.545 -6. 853 -34. 941 1.00 24. ,30 H 0

ATOM 8290 NE2 GLN H 113 11.841 -6. 506 -32. 733 1.00 25. ,24 H N

ATOM 8293 C GLN H 113 13.559 -10. ,441 -35. 099 1.00 27. ,87 H C

ATOM 8294 O GLN H 113 14.615 -10. ,938 -34. 695 1.00 24. ,88 H 0

ATOM 8296 N GLY H 114 12.358 -10. ,888 -34. 737 1.00 26. ,83 H N

ATOM 8297 CA GLY H 114 12.175 -11. ,930 -33. 735 1.00 25. .49 H C

ATOM 8300 C GLY H 114 11.842 -11. .386 -32. ,370 1.00 28. ,17 H C

ATOM 8301 O GLY H 114 12.221 -10. ,274 -32. ,041 1.00 31. ,34 H 0

ATOM 8303 N THR H 115 11.087 -12. ,172 -31. 600 1.00 28. ,55 H N

ATOM 8304 CA THR H 115 10.838 -11. 953 -30. 181 1.00 25, ,21 H c

ATOM 8306 CB THR H 115 9.316 -11. ,733 -29. 891 1.00 27, ,30 H c

ATOM 8308 OG1 THR H 115 8.819 -10. ,600 -30. 629 1.00 26. ,56 H 0

ATOM 8310 CG2 THR H 115 9.065 -11.518 -28. 418 1.00 24. ,09 H c

ATOM 8314 C THR H 115 11.313 -13. ,233 -29. 453 1.00 27. ,22 H c

ATOM 8315 O THR H 115 10.913 -14. ,331 -29. ,827 1.00 27, ,51 H 0

ATOM 8317 N LEU H 116 12.179 -13. ,106 -28. ,444 1.00 26. .19 H N

ATOM 8318 CA LEU H 116 12.580 -14, ,274 -27. ,647 1.00 25, ,35 H c

ATOM 8320 CB LEU H 116 14.056 -14. ,211 -27. ,185 1.00 24. .29 H c

ATOM 8323 CG LEU H 116 14.620 -15. ,254 -26. ,185 1.00 24, .64 H c

ATOM 8325 CDl LEU H 116 14.480 -16. ,702 -26. ,604 1.00 21. ,54 H c

ATOM 8329 CD2 LEU H 116 16.091 -14. ,995 -25. 904 1.00 26. ,59 H c

ATOM 8333 C LEU H 116 11.644 -14. ,327 -26. ,466 1.00 25. ,68 H c

ATOM 8334 O LEU H 116 11.549 -13. ,374 -25. ,706 1.00 25, .56 H 0

ATOM 8336 N VAL H 117 10.921 -15. ,433 -26. ,348 1.00 25, .43 H N

ATOM 8337 CA VAL H 117 10.101 -15. ,696 -25. ,182 1.00 17, .92 H c

ATOM 8339 CB VAL H 117 8.679 -16. ,133 -25. ,576 1.00 17. .75 H c

ATOM 8341 CGI VAL H 117 7.822 -16, ,410 -24. ,318 1.00 14, .64 H c

ATOM 8345 CG2 VAL H 117 8.034 -15. ,077 -26. ,455 1.00 17. .75 H c

ATOM 8349 C VAL H 117 10.767 -16. ,794 -24. ,364 1.00 17. .37 H c

ATOM 8350 O VAL H 117 11.029 -17, ,882 -24. ,870 1.00 12, ,33 H 0

ATOM 8352 N THR H 118 11.033 -16. ,505 -23. ,091 1.00 23, .95 H N

ATOM 8353 CA THR H 118 11.612 -17. .474 -22. ,172 1.00 22, .92 H c

ATOM 8355 CB THR H 118 12.809 -16. ,857 -21. ,406 1.00 27, ,19 H c

ATOM 8357 OGl THR H 118 13.689 -16, ,202 -22. ,330 1.00 25, .50 H 0

ATOM 8359 CG2 THR H 118 13.578 -17, ,919 -20. ,628 1.00 26, .58 H c

ATOM 8363 C THR H 118 10.521 -17, ,888 -21. ,185 1.00 24, .48 H c cyno fD_Fab

ATOM 8364 O THR H 118 9. ,863 -17. ,032 -20. ,590 1. 00 23. ,34 H 0

ATOM 8366 N VAL H 119 10. ,286 -19. ,190 -21. ,049 1. 00 24. ,92 H N

ATOM 8367 CA VAL H 119 9. ,358 -19. 673 -20. ,031 1. 00 23. ,47 H C

ATOM 8369 CB VAL H 119 8. ,319 -20. 684 -20. ,569 1. 00 15. ,83 H C

ATOM 8371 CGl VAL H 119 7. ,400 -21. 149 -19. 426 1. 00 20. ,19 H c

ATOM 8375 CG2 VAL H 119 7. 473 -20. 048 -21.679 1. 00 11. ,41 H c

ATOM 8379 C VAL H 119 10. 154 -20. 290 -18. 885 1. 00 25. ,93 H c

ATOM 8380 O VAL H 119 10. ,779 -21. ,336 -19. ,051 1. 00 23. ,45 H 0

ATOM 8382 N SER H 120 10. ,139 -19. ,622 -17. ,731 1. 00 29. ,66 H N

ATOM 8383 CA SER H 120 10. ,841 -20. ,115 -16. ,538 1. 00 33. ,71 H c

ATOM 8385 CB SER H 120 12. 296 -19. 631 -16. ,546 1. 00 35. ,78 H c

ATOM 8388 OG SER H 120 12. 978 -20. 008 -15. ,361 1. 00 35. ,68 H 0

ATOM 8390 C SER H 120 10. 149 -19. 636 -15. ,270 1. 00 32. ,74 H c

ATOM 8391 O SER H 120 9. 485 -18. 600 -15. 292 1. 00 33. ,43 H 0

ATOM 8393 N SER H 121 10. 307 -20. 388 -14. 176 1. 00 35. ,59 H N

ATOM 8394 CA SER H 121 9. 823 -19. 942 -12. 848 1. 00 40. ,05 H c

ATOM 8396 CB SER H 121 9. 795 -21. 097 -11.832 1. 00 41. ,66 H c

ATOM 8399 OG SER H 121 8. ,549 -21. 773 -11. ,851 1. 00 42. ,51 H 0

ATOM 8401 C SER H 121 10. ,679 -18. 809 -12. ,284 1. 00 41. ,69 H c

ATOM 8402 O SER H 121 10. 228 -18. 079 -11. ,409 1. 00 42. ,91 H 0

ATOM 8404 N ALA H 122 11. 912 -18. 680 -12. 782 1. 00 44. ,09 H N

ATOM 8405 CA ALA H 122 12. 863 -17. 670 -12. ,307 1. 00 43. 86 H c

ATOM 8407 CB ALA H 122 14. 224 -17. 882 -12. ,963 1. 00 44. ,95 H c

ATOM 8411 C ALA H 122 12. 380 -16. 248 -12. 565 1. 00 45. ,54 H c

ATOM 8412 O ALA H 122 11. 695 -15. 983 -13. 556 1. 00 47. ,85 H 0

ATOM 8414 N SER H 123 12. 739 -15. 338 -11. 662 1. 00 45. ,30 H N

ATOM 8415 CA SER H 123 12. 402 -13. 920 -11.803 1. 00 45. ,61 H c

ATOM 8417 CB SER H 123 12. 273 -13. 270 -10. 427 1. 00 47. ,10 H c

ATOM 8420 OG SER H 123 13. 268 -13. 766 -9. ,548 1. 00 49. ,06 H 0

ATOM 8422 C SER H 123 13. 444 -13. 181 -12. ,655 1. 00 44. ,44 H c

ATOM 8423 O SER H 123 14. 572 -13. 660 -12. 839 1. 00 40. ,43 H 0

ATOM 8425 N THR H 124 13. 053 -12. 017 -13. ,171 1. 00 45. 08 H N

ATOM 8426 CA THR H 124 13. 932 -11. 201 -14. 010 1. 00 46. ,45 H c

ATOM 8428 CB THR H 124 13. 131 -10. 126 -14. 806 1. 00 49. 48 H c

ATOM 8430 OGl THR H 124 13. 984 -9. 503 -15. ,777 1. 00 51.02 H 0

ATOM 8432 CG2 THR H 124 12. 539 -9. 060 -13. ,877 1. 00 50. ,62 H c

ATOM 8436 C THR H 124 15. 043 -10. 537 -13. ,180 1. 00 46. ,82 H c

ATOM 8437 O THR H 124 14. 781 -9. 976 -12. 106 1. 00 48. ,27 H 0

ATOM 8439 N LYS H 125 16. 280 -10. 630 -13. ,670 1. 00 44. ,93 H N

ATOM 8440 CA LYS H 125 17. 426 -9. ,981 -13. ,032 1. 00 43. ,78 H c

ATOM 8442 CB LYS H 125 18. 288 -10. ,999 -12. ,269 1. 00 45. ,93 H c

ATOM 8445 CG LYS H 125 18. 972 -10. ,411 -11. ,018 1. 00 45. ,78 H c

ATOM 8448 CD LYS H 125 20. 118 -11. 290 -10. ,503 1. 00 46. ,44 H c

ATOM 8451 CE LYS H 125 20. 175 -11. ,316 -8. ,970 1. 00 47. ,72 H c

ATOM 8454 NZ LYS H 125 20. 117 -9. 956 -8. ,344 1. 00 47. ,92 H N

ATOM 8458 C LYS H 125 18. 282 -9. 264 -14. ,076 1. 00 42. ,52 H c

ATOM 8459 O LYS H 125 18. 628 -9. 849 -15. ,110 1. 00 37. ,91 H 0

ATOM 8461 N GLY H 126 18. 623 -8. 004 -13. ,788 1. 00 39. ,38 H N

ATOM 8462 CA GLY H 126 19. 497 -7. 206 -14. ,643 1. 00 37. ,54 H c

ATOM 8465 C GLY H 126 20. ,952 -7. ,521 -14. ,360 1. 00 35. .67 H c

ATOM 8466 O GLY H 126 21. ,295 -7. ,850 -13. ,223 1. 00 34. .54 H 0

ATOM 8468 N PRO H 127 21. 820 -7. ,419 -15. ,386 1. 00 35. .15 H N

ATOM 8469 CA PRO H 127 23. 225 -7. ,806 -15. ,243 1. 00 36. .68 H C

ATOM 8471 CB PRO H 127 23. 735 -7. ,849 -16. ,691 1. 00 36. ,51 H C

ATOM 8474 CG PRO H 127 22. 860 -6. ,921 -17. ,437 1. 00 36. ,24 H c

ATOM 8477 CD PRO H 127 21. 521 -6. ,921 -16. ,742 1. 00 36. ,45 H c

ATOM 8480 C PRO H 127 24. 086 -6. ,832 -14. 438 1. 00 38. ,63 H c

ATOM 8481 O PRO H 127 23. 705 -5. 677 -14. ,222 1. 00 40. ,90 H 0

ATOM 8482 N SER H 128 25. 236 -7. 335 -13. ,998 1. 00 36. ,31 H N

ATOM 8483 CA SER H 128 26. ,320 -6. ,519 -13. ,493 1. 00 34, ,83 H c

ATOM 8485 CB SER H 128 26. 834 -7. ,080 -12. ,165 1. 00 33, .89 H c

ATOM 8488 OG SER H 128 25. 866 -6. 929 -11. ,137 1. 00 31, .42 H 0

ATOM 8490 C SER H 128 27. ,420 -6. 540 -14. ,551 1. 00 34, ,96 H c

ATOM 8491 O SER H 128 27. 811 -7. 602 -15. ,021 1. 00 30, .40 H 0

ATOM 8493 N VAL H 129 27. 895 -5. 363 -14. ,943 1. 00 36, .06 H N

ATOM 8494 CA VAL H 129 28. 932 -5. 253 -15. ,964 1. 00 34, .28 H c

ATOM 8496 CB VAL H 129 28. 555 -4. 218 -17. ,054 1. 00 33. .77 H c

ATOM 8498 CGl VAL H 129 29. 584 -4. 213 -18. ,178 1. 00 35. .46 H c cyno fD_Fab

ATOM 8502 CG2 VAL H 129 27. 170 -4. .498 -17. ,601 1.00 30. .77 H C

ATOM 8506 C VAL H 129 30. 242 -4. 855 -15. ,284 1.00 32. .58 H C

ATOM 8507 O VAL H 129 30. ,314 -3. ,824 -14. ,611 1.00 34. .17 H 0

ATOM 8509 N PHE H 130 31.256 -5. ,701 -15. ,447 1.00 32. ,41 H N

ATOM 8510 CA PHE H 130 32. 592 -5. ,465 -14. ,917 1.00 33. ,72 H C

ATOM 8512 CB PHE H 130 33. 018 -6. ,606 -13. ,981 1.00 33. ,49 H C

ATOM 8515 CG PHE H 130 32. 019 -6. ,918 -12. ,898 1.00 32. ,75 H C

ATOM 8516 CDl PHE H 130 31. 769 -6. ,007 -11. ,883 1.00 32. ,01 H c

ATOM 8518 CEl PHE H 130 30. 846 -6. ,288 -10. .883 1.00 32. ,30 H c

ATOM 8520 CZ PHE H 130 30. 171 -7. ,491 -10. ,886 1.00 32. ,77 H c

ATOM 8522 CE2 PHE H 130 30. 414 -8. ,412 -11.893 1.00 33. ,10 H c

ATOM 8524 CD2 PHE H 130 31. 338 -8. ,127 -12. 888 1.00 32. ,02 H c

ATOM 8526 C PHE H 130 33. 576 -5. ,379 -16. 082 1.00 34. ,31 H c

ATOM 8527 O PHE H 130 33. 401 -6. ,056 -17. 088 1.00 35. ,96 H 0

ATOM 8529 N PRO H 131 34. 618 -4. ,540 -15. ,954 1.00 35. ,83 H N

ATOM 8530 CA PRO H 131 35. 599 -4. ,412 -17. .033 1.00 34. ,25 H c

ATOM 8532 CB PRO H 131 36. 390 -3. 163 -16. ,634 1.00 35. ,48 H c

ATOM 8535 CG PRO H 131 36. 292 -3. 113 -15. ,147 1.00 34. ,74 H c

ATOM 8538 CD PRO H 131 34. 929 -3. ,656 -14. ,811 1.00 33. ,90 H c

ATOM 8541 C PRO H 131 36. 540 -5. ,602 -17. 138 1.00 31. 80 H c

ATOM 8542 O PRO H 131 36. 770 -6. 297 -16. 156 1.00 32. 76 H 0

ATOM 8543 N LEU H 132 37. 054 -5. 832 -18. ,339 1.00 33. ,15 H N

ATOM 8544 CA LEU H 132 38. 171 -6. ,740 -18. ,563 1.00 36. 33 H C

ATOM 8546 CB LEU H 132 37. 803 -7. 848 -19. ,560 1.00 36. 81 H C

ATOM 8549 CG LEU H 132 36. 663 -8. 793 -19. ,159 1.00 35. ,77 H C

ATOM 8551 CDl LEU H 132 36. 248 -9. 650 -20. ,337 1.00 32. ,21 H C

ATOM 8555 CD2 LEU H 132 37. 060 -9. 660 -17. ,977 1.00 32. ,93 H c

ATOM 8559 C LEU H 132 39. 284 -5. 859 -19. ,104 1.00 35. 97 H c

ATOM 8560 O LEU H 132 39. 373 -5. ,617 -20. ,306 1.00 36. ,14 H 0

ATOM 8562 N ALA H 133 40. 105 -5. 352 -18. ,193 1.00 39. 87 H N

ATOM 8563 CA ALA H 133 41. 058 -4. 293 -18. ,503 1.00 43. ,26 H c

ATOM 8565 CB ALA H 133 41. 570 -3. 654 -17. ,216 1.00 42. ,36 H c

ATOM 8569 C ALA H 133 42. 229 -4. ,803 -19. ,334 1.00 46. ,24 H c

ATOM 8570 O ALA H 133 42. 669 -5. ,942 -19. ,157 1.00 46. ,65 H 0

ATOM 8572 N PRO H 134 42. 751 -3. 952 -20. ,238 1.00 49. ,34 H N

ATOM 8573 CA PRO H 134 43. 908 -4. 344 -21. ,036 1.00 51. ,17 H c

ATOM 8575 CB PRO H 134 43. 853 -3. 384 -22. ,228 1.00 48. ,58 H c

ATOM 8578 CG PRO H 134 43. 136 -2. 179 -21. ,730 1.00 47. 99 H c

ATOM 8581 CD PRO H 134 42. 299 -2. ,580 -20. .548 1.00 47. ,37 H c

ATOM 8584 C PRO H 134 45. 213 -4 . ,195 -20. .255 1.00 55. ,13 H c

ATOM 8585 O PRO H 134 45. 265 -3. ,457 -19. .272 1.00 57. ,14 H 0

ATOM 8586 N SER H 135 46. 254 -4 . ,894 -20. .690 1.00 59. ,44 H N

ATOM 8587 CA SER H 135 47. 546 -4. ,863 -20. .004 1.00 64. ,17 H C

ATOM 8589 CB SER H 135 47. 508 -5. ,803 -18. ,794 1.00 63. ,79 H c

ATOM 8592 OG SER H 135 47. 188 -7. ,126 -19. ,191 1.00 62. ,73 H 0

ATOM 8594 C SER H 135 48. 662 -5. ,261 -20. ,973 1.00 69. ,77 H c

ATOM 8595 0 SER H 135 48. 429 -5. 335 -22. ,183 1.00 70. ,48 H 0

ATOM 8597 N SER H 136 49. 871 -5. ,493 -20. ,455 1.00 74. ,01 H N

ATOM 8598 CA SER H 136 50. 955 -6. ,075 -21.260 1.00 76. ,51 H c

ATOM 8600 CB SER H 136 52. 310 -5. ,910 -20. .561 1.00 75. ,21 H c

ATOM 8603 OG SER H 136 52. 475 -6. ,860 -19. .520 1.00 73. ,40 H 0

ATOM 8605 C SER H 136 50. 699 -7. ,565 -21. .570 1.00 81. ,86 H c

ATOM 8606 0 SER H 136 51. 169 -8. ,073 -22. .595 1.00 82. ,53 H 0

ATOM 8608 N LYS H 137 49. 962 -8. ,249 -20. ,681 1.00 85. ,95 H N

ATOM 8609 CA LYS H 137 49. 586 -9. ,677 -20. ,851 1.00 85. ,58 H c

ATOM 8611 CB LYS H 137 49. 404 -10. 380 -19. .489 1.00 85. ,07 H c

ATOM 8614 CG LYS H 137 50. 663 -11. ,056 -18. .938 1.00 83. ,96 H c

ATOM 8617 CD LYS H 137 50. 949 -12. ,389 -19. ,621 1.00 83. ,33 H c

ATOM 8620 CE LYS H 137 52. 144 -13. ,094 -18. ,991 1.00 83. .38 H c

ATOM 8623 NZ LYS H 137 52. 350 -14. ,469 -19. .528 1.00 81. .97 H N

ATOM 8627 C LYS H 137 48. 319 -9. ,864 -21. .701 1.00 87. , 99 H c

ATOM 8628 0 LYS H 137 48. 094 -10. ,953 -22. .246 1.00 87. ,19 H 0

ATOM 8630 N SER H 138 47. 492 -8. ,816 -21.789 1.00 89. ,89 H N

ATOM 8631 CA SER H 138 46. 409 -8. 759 -22. .786 1.00 89. ,19 H c

ATOM 8633 CB SER H 138 45. 152 -8. 063 -22. .240 1.00 87. 09 H c

ATOM 8636 OG SER H 138 44. 981 -6. 777 -22. ,805 1.00 85. ,82 H 0

ATOM 8638 C SER H 138 46. 901 -8. ,067 -24. .076 1.00 90. ,89 H c

ATOM 8639 0 SER H 138 46. 111 -7. ,837 -24. ,993 1.00 91.36 H 0 cyno fD_Fab

ATOM 8641 N THR H 139 48. .198 -7. ,735 -24. 123 1.00 91. ,70 H N

ATOM 8642 CA THR H 139 48. ,863 -7. ,192 -25. ,315 1.00 90. ,51 H C

ATOM 8644 CB THR H 139 49. ,881 -6. .047 -24. ,953 1.00 91. 36 H C

ATOM 8646 OGl THR H 139 49. ,175 -4. ,836 -24. ,640 1.00 90. 80 H 0

ATOM 8648 CG2 THR H 139 50. ,854 -5. ,774 -26. ,105 1.00 90. 91 H C

ATOM 8652 C THR H 139 49. ,586 -8. ,321 -26. ,057 1.00 89. 25 H c

ATOM 8653 O THR H 139 50. ,165 -9. ,216 -25. ,433 1.00 88. 53 H 0

ATOM 8655 N SER H 140 49. ,537 -8. ,268 -27. ,388 1.00 88. 72 H N

ATOM 8656 CA SER H 140 50. ,203 -9. ,239 -28. ,260 1.00 87. ,83 H c

ATOM 8658 CB SER H 140 49. ,166 -9. ,896 -29. ,187 1.00 88. 22 H C

ATOM 8661 OG SER H 140 49. ,601 -11. ,168 -29. ,637 1.00 88. 23 H 0

ATOM 8663 C SER H 140 51. 307 -8. ,524 -29. ,064 1.00 87. ,24 H c

ATOM 8664 0 SER H 140 51. 348 -8. ,590 -30. ,300 1.00 86. 84 H 0

ATOM 8666 N GLY H 141 52. 202 -7. ,843 -28. ,343 1.00 84. 48 H N

ATOM 8667 CA GLY H 141 53. ,181 -6. ,941 -28. ,955 1.00 80. 57 H c

ATOM 8670 C GLY H 141 52. ,551 -5. ,596 -29. 299 1.00 79. 17 H c

ATOM 8671 O GLY H 141 52. ,744 -4. ,607 -28. ,579 1.00 80. 70 H 0

ATOM 8673 N GLY H 142 51.787 -5. ,570 -30. 394 1.00 73. 79 H N

ATOM 8674 CA GLY H 142 51. ,143 -4. ,346 -30. ,892 1.00 68. ,18 H c

ATOM 8677 C GLY H 142 49. ,621 -4. ,282 -30. ,787 1.00 64. 43 H c

ATOM 8678 0 GLY H 142 49. ,046 -3. ,201 -30. ,948 1.00 64. 56 H 0

ATOM 8680 N THR H 143 48. ,967 -5. 424 -30. ,540 1.00 58. 05 H N

ATOM 8681 CA THR H 143 47. 507 -5. 486 -30. ,356 1.00 53. 53 H c

ATOM 8683 CB THR H 143 46. ,874 -6. 581 -31. ,214 1.00 52. 89 H c

ATOM 8685 OGl THR H 143 46. 968 -6. 213 -32. ,592 1.00 53. 54 H 0

ATOM 8687 CG2 THR H 143 45. ,409 -6. ,766 -30. ,855 1.00 54. 98 H c

ATOM 8691 C THR H 143 47. 155 -5. 781 -28. ,908 1.00 48. 91 H c

ATOM 8692 O THR H 143 47. 838 -6. ,556 -28. 255 1.00 47. 43 H 0

ATOM 8694 N ALA H 144 46. ,078 -5. ,168 -28. ,420 1.00 46. ,93 H N

ATOM 8695 CA ALA H 144 45. ,628 -5. ,345 -27. ,040 1.00 43. 98 H c

ATOM 8697 CB ALA H 144 45. ,801 -4. ,056 -26. ,254 1.00 44. 69 H c

ATOM 8701 C ALA H 144 44. ,173 -5. ,798 -27. ,000 1.00 42. ,19 H c

ATOM 8702 O ALA H 144 43. 333 -5. 312 -27. 764 1.00 39. ,08 H 0

ATOM 8704 N ALA H 145 43. 878 -6. 727 -26. 098 1.00 40. 02 H N

ATOM 8705 CA ALA H 145 42. ,515 -7. ,190 -25. ,896 1.00 36. 52 H c

ATOM 8707 CB ALA H 145 42. ,483 -8. ,692 -25. .714 1.00 35. 06 H c

ATOM 8711 C ALA H 145 41.930 -6. ,503 -24. ,677 1.00 35. 07 H c

ATOM 8712 O ALA H 145 42. 610 -6. ,330 -23. ,658 1.00 31. 26 H 0

ATOM 8714 N LEU H 146 40. ,673 -6. ,090 -24. ,795 1.00 32. ,96 H N

ATOM 8715 CA LEU H 146 39. ,916 -5. ,599 -23. ,649 1.00 31. ,62 H c

ATOM 8717 CB LEU H 146 39. ,994 -4. ,065 -23. ,540 1.00 32. ,12 H c

ATOM 8720 CG LEU H 146 39. ,458 -3. ,147 -24. ,653 1.00 31. ,54 H c

ATOM 8722 CDl LEU H 146 38. ,004 -2. ,754 -24. ,416 1.00 31. ,93 H c

ATOM 8726 CD 2 LEU H 146 40. ,304 -1. ,889 -24. ,740 1.00 31. 46 H c

ATOM 8730 C LEU H 146 38. ,493 -6. ,107 -23. ,816 1.00 30. ,16 H c

ATOM 8731 O LEU H 146 38. ,157 -6. ,658 -24. ,863 1.00 29. 67 H 0

ATOM 8733 N GLY H 147 37. 670 -5. ,962 -22. ,784 1.00 25. ,21 H N

ATOM 8734 CA GLY H 147 36. 299 -6. ,412 -22. ,872 1.00 24. ,17 H c

ATOM 8737 C GLY H 147 35. ,433 -6. ,016 -21. ,704 1.00 24. ,31 H c

ATOM 8738 O GLY H 147 35. ,834 -5. ,225 -20. ,862 1.00 28. ,77 H 0

ATOM 8740 N CYS H 148 34. ,221 -6, ,551 -21. ,685 1.00 26. ,43 H N

ATOM 8741 CA CYS H 148 33. ,313 -6. ,393 -20. ,563 1.00 27. ,92 H c

ATOM 8743 CB CYS H 148 32. 165 -5. ,448 -20. ,926 1.00 33. ,54 H c

ATOM 8746 SG CYS H 148 32. 656 -3. ,722 -20. ,942 1.00 40. ,27 H s

ATOM 8748 C CYS H 148 32. ,755 -7. ,750 -20. ,196 1.00 24. ,83 H c

ATOM 8749 0 CYS H 148 32. 440 -8, ,540 -21. ,078 1.00 24. ,93 H 0

ATOM 8751 N LEU H 149 32. ,650 -8. Oil -18. ,895 1.00 26. ,36 H N

ATOM 8752 CA LEU H 149 32. ,001 -9. ,212 -18. ,381 1.00 26. ,22 H c

ATOM 8754 CB LEU H 149 32. ,773 -9. ,778 -17. ,181 1.00 23. ,19 H c

ATOM 8757 CG LEU H 149 32. ,149 -10. ,967 -16. ,435 1.00 23. ,06 H c

ATOM 8759 CDl LEU H 149 32. ,183 -12, ,250 -17. ,259 1.00 15. ,50 H c

ATOM 8763 CD2 LEU H 149 32. ,845 -11. ,174 -15. ,100 1.00 23. ,82 H c

ATOM 8767 C LEU H 149 30. ,580 -8. ,835 -17. ,981 1.00 24. ,48 H c

ATOM 8768 0 LEU H 149 30. 372 -8, ,039 -17. ,066 1.00 26. ,66 H 0

ATOM 8770 N VAL H 150 29. ,600 -9. ,385 -18. ,686 1.00 27. ,87 H N

ATOM 8771 CA VAL H 150 28. ,199 -9. ,146 -18. ,358 1.00 28. ,86 H c

ATOM 8773 CB VAL H 150 27. ,338 -8. ,937 -19. ,625 1.00 27. ,47 H c

ATOM 8775 CGl VAL H 150 25. ,948 -8. ,463 -19. ,244 1.00 26. ,91 H c cyno fD_Fab

ATOM 8779 CG2 VAL H 150 28. ,000 -7. ,938 -20. ,563 1. 00 26. 57 H C

ATOM 8783 C VAL H 150 27. 737 -10. ,371 -17. ,582 1. 00 30. 06 H C

ATOM 8784 O VAL H 150 27. ,628 -11. ,442 -18. ,148 1. 00 29. ,12 H 0

ATOM 8786 N LYS H 151 27. ,489 -10. ,205 -16. ,284 1. 00 31. ,47 H N

ATOM 8787 CA LYS H 151 27. 308 -11. ,332 -15. ,369 1. 00 31. ,13 H C

ATOM 8789 CB LYS H 151 28. 487 -11. ,381 -14. 393 1. 00 33. ,71 H C

ATOM 8792 CG LYS H 151 28. ,454 -12. 559 -13. ,441 1. 00 34. ,95 H c

ATOM 8795 CD LYS H 151 29. 817 -12. 867 -12. 861 1. 00 36. ,04 H c

ATOM 8798 CE LYS H 151 29. 733 -14. ,029 -11. ,884 1. 00 36. 42 H c

ATOM 8801 NZ LYS H 151 28. 924 -13. 662 -10. 695 1. 00 36. 41 H N

ATOM 8805 C LYS H 151 25. 988 -11. ,268 -14. ,597 1. 00 26. 95 H C

ATOM 8806 O LYS H 151 25. 433 -10. ,199 -14. ,406 1. 00 24. ,48 H 0

ATOM 8808 N ASP H 152 25. ,494 -12. 439 -14. ,196 1. 00 28. ,87 H N

ATOM 8809 CA ASP H 152 24. 293 -12. ,607 -13. ,355 1. 00 30. ,95 H C

ATOM 8811 CB ASP H 152 24. ,611 -12. ,269 -11. ,889 1. 00 30. 79 H C

ATOM 8814 CG ASP H 152 25. 612 -13. ,245 -11. ,256 1. 00 32. ,61 H c

ATOM 8815 OOl ASP H 152 25. 662 -14. ,424 -11. ,665 1. 00 30. ,49 H 0

ATOM 8816 002 ASP H 152 26. 339 -12. ,833 -10. ,323 1. 00 35. 78 H 0

ATOM 8817 C ASP H 152 23. 023 -11. ,873 -13. ,818 1. 00 30. 02 H c

ATOM 8818 0 ASP H 152 22. 449 -11. ,074 -13. ,073 1. 00 29. 03 H 0

ATOM 8820 N TYR H 153 22. ,579 -12. ,182 -15. ,039 1. 00 31. ,11 H N

ATOM 8821 CA TYR H 153 21. ,302 -11. ,685 -15. ,564 1. 00 28. ,57 H c

ATOM 8823 CB TYR H 153 21.523 -10. ,717 -16. ,728 1. 00 25. 83 H c

ATOM 8826 CG TYR H 153 22. 111 -11. ,333 -17. ,974 1. 00 25. ,30 H c

ATOM 8827 CDl TYR H 153 21. 290 -11.823 -18. ,987 1. 00 25. 48 H c

ATOM 8829 CEl TYR H 153 21. 817 -12. ,383 -20. ,129 1. 00 23. 23 H c

ATOM 8831 CZ TYR H 153 23. 185 -12. ,451 -20. ,285 1. 00 25. 09 H c

ATOM 8832 OH TYR H 153 23. 714 -13. ,006 -21. ,437 1. 00 23. 64 H 0

ATOM 8834 CE2 TYR H 153 24. 027 -11.963 -19. ,296 1. 00 22. 64 H c

ATOM 8836 CD2 TYR H 153 23. 485 -11. ,410 -18. ,150 1. 00 25. ,88 H c

ATOM 8838 C TYR H 153 20. 387 -12. ,806 -16. ,031 1. 00 27. 96 H c

ATOM 8839 0 TYR H 153 20. 839 -13. ,895 -16. 392 1. 00 26. 67 H 0

ATOM 8841 N PHE H 154 19. 094 -12. ,509 -16. 038 1. 00 31. ,15 H N

ATOM 8842 CA PHE H 154 18. 081 -13. ,432 -16. 536 1. 00 31. 14 H c

ATOM 8844 CB PHE H 154 17. 779 -14. ,487 -15. ,469 1. 00 36. ,10 H c

ATOM 8847 CG PHE H 154 16. 937 -15. ,633 -15. 957 1. 00 33. 94 H c

ATOM 8848 CDl PHE H 154 17. 529 -16. ,763 -16. ,495 1. 00 35. ,71 H c

ATOM 8850 CEl PHE H 154 16. 752 -17. ,831 -16. ,944 1. 00 37. ,65 H c

ATOM 8852 CZ PHE H 154 15. 368 -17. ,773 -16. ,839 1. 00 37. ,20 H c

ATOM 8854 CE2 PHE H 154 14. 769 -16. ,656 -16. ,293 1. 00 36. ,49 H c

ATOM 8856 CD2 PHE H 154 15. 552 -15. ,592 -15. ,850 1. 00 36. ,52 H c

ATOM 8858 C PHE H 154 16. 811 -12. 655 -16. ,891 1. 00 29. ,72 H c

ATOM 8859 0 PHE H 154 16. 451 -11. ,692 -16. ,196 1. 00 34. 72 H 0

ATOM 8861 N PRO H 155 16. 122 -13. ,051 -17. ,971 1. 00 28. 19 H N

ATOM 8862 CA PRO H 155 16. 424 -14. ,094 -18. ,977 1. 00 29. ,98 H c

ATOM 8864 CB PRO H 155 15. 056 -14. ,339 -19. ,617 1. 00 31. ,81 H c

ATOM 8867 CG PRO H 155 14. 393 -12. ,997 -19. ,557 1. 00 30. ,17 H c

ATOM 8870 CD PRO H 155 14. 824 -12. ,403 -18. ,238 1. 00 28. ,41 H c

ATOM 8873 C PRO H 155 17. ,403 -13. ,624 -20. ,046 1. 00 30. ,23 H c

ATOM 8874 0 PRO H 155 18. 026 -12. ,588 -19. ,897 1. 00 32. ,39 H 0

ATOM 8875 N GLU H 156 17. 541 -14. ,387 -21. ,121 1. 00 30. ,02 H N

ATOM 8876 CA GLU H 156 18. 088 -13. ,837 -22. ,346 1. 00 29. ,65 H c

ATOM 8878 CB GLU H 156 18. 420 -14. ,957 -23. ,334 1. 00 28. ,94 H c

ATOM 8881 CG GLU H 156 19. 667 -15. ,759 -22. ,979 1. 00 28. ,50 H c

ATOM 8884 CD GLU H 156 20. 933 -15. ,184 -23. ,591 1. 00 32. 86 H c

ATOM 8885 OEl GLU H 156 21. ,147 -13. ,954 -23. .502 1. 00 33. ,46 H 0

ATOM 8886 0E2 GLU H 156 21. ,714 -15. .970 -24. ,169 1. 00 35. ,71 H 0

ATOM 8887 C GLU H 156 17. 043 -12. ,875 -22. .942 1. 00 30. ,49 H c

ATOM 8888 0 GLU H 156 15. ,865 -12. ,927 -22. .568 1. 00 27. ,37 H 0

ATOM 8890 N PRO H 157 17. 463 -11. ,990 -23. ,871 1. 00 29. ,67 H N

ATOM 8891 CA PRO H 157 18. 823 -11. ,747 -24. ,334 1. 00 30. ,63 H c

ATOM 8893 CB PRO H 157 18. 641 -11. ,662 -25. ,850 1. 00 28. ,90 H c

ATOM 8896 CG PRO H 157 17. 218 -11. ,160 -26. ,033 1. 00 28. ,41 H c

ATOM 8899 CD PRO H 157 16. 527 -11. ,188 -24. ,662 1. 00 26. ,70 H c

ATOM 8902 C PRO H 157 19. ,435 -10.445 -23, .820 1. 00 30. ,25 H c

ATOM 8903 0 PRO H 157 18. ,745 -9. .581 -23, ,286 1. 00 30. ,38 H 0

ATOM 8904 N VAL H 158 20. ,743 -10. .335 -23, .993 1. 00 33. ,31 H N

ATOM 8905 CA VAL H 158 21. ,472 -9. ,110 -23. .742 1. 00 35. ,79 H c cyno fD_Fab

ATOM 8907 CB VAL H 158 22 574 -9. 346 -22 672 1.00 36 57 H C

ATOM 8909 CGI VAL H 158 23 718 -8. 354 -22 807 1.00 35 84 H C

ATOM 8913 CG2 VAL H 158 21 964 -9. 270 -21 280 1.00 39 04 H C

ATOM 8917 C VAL H 158 22 065 -8. 670 -25 076 1.00 38 64 H C

ATOM 8918 O VAL H 158 22 383 -9. 511 -25 917 1.00 38 95 H 0

ATOM 8920 N THR H 159 22 171 -7. 360 -25 285 1.00 38 90 H N

ATOM 8921 CA THR H 159 22 879 -6. 821 -26 448 1.00 37 16 H C

ATOM 8923 CB THR H 159 21 970 -5. 923 -27 314 1.00 38 92 H C

ATOM 8925 OGl THR H 159 21 381 -4. 906 -26 497 1.00 41.56 H 0

ATOM 8927 CG2 THR H 159 20 869 -6. 742 -27 963 1.00 39 04 H c

ATOM 8931 C THR H 159 24 085 -6. 020 -25 963 1.00 37 27 H c

ATOM 8932 0 THR H 159 24 012 -5. 326 -24 947 1.00 32 88 H 0

ATOM 8934 N VAL H 160 25 198 -6. 136 -26 677 1.00 34 27 H N

ATOM 8935 CA VAL H 160 26 406 -5. 400 -26 339 1.00 32 63 H c

ATOM 8937 CB VAL H 160 27 470 -6. 292 -25 654 1.00 28 82 H c

ATOM 8939 CGI VAL H 160 28 608 -5. 433 -25 087 1.00 27 01 H c

ATOM 8943 CG2 VAL H 160 26 846 -7. 136 -24 548 1.00 26 36 H c

ATOM 8947 C VAL H 160 26 996 -4. 769 -27 599 1.00 33 92 H c

ATOM 8948 0 VAL H 160 27 255 -5. 457 -28 600 1.00 33 73 H 0

ATOM 8950 N SER H 161 27 187 -3. 454 -27 543 1.00 38 78 H N

ATOM 8951 CA SER H 161 27 907 -2. 712 -28 577 1.00 38 50 H c

ATOM 8953 CB SER H 161 26 962 -1. 744 -29 318 1.00 41 32 H c

ATOM 8956 OG SER H 161 26 289 -0. 859 -28 428 1.00 40 60 H 0

ATOM 8958 C SER H 161 29 089 -1. 966 -27 938 1.00 36 58 H c

ATOM 8959 0 SER H 161 29 195 -1. 877 -26 713 1.00 28 41 H 0

ATOM 8961 N TRP H 162 29 979 -1. 454 -28 782 1.00 38 67 H N

ATOM 8962 CA TRP H 162 31 176 -0. 761 -28 330 1.00 40 23 H C

ATOM 8964 CB TRP H 162 32 414 -1. 546 -28 744 1.00 39 85 H c

ATOM 8967 CG TRP H 162 32 665 -2. 733 -27 892 1.00 40 70 H c

ATOM 8968 CDl TRP H 162 32 249 -4. 013 -28 122 1.00 39 62 H c

ATOM 8970 NEl TRP H 162 32 672 -4. 836 -27 106 1.00 40 17 H N

ATOM 8972 CE2 TRP H 162 33 381 -4. 094 -26 198 1.00 40 23 H c

ATOM 8973 CD2 TRP H 162 33 394 -2. 759 -26 662 1.00 39 34 H c

ATOM 8974 CE3 TRP H 162 34 057 -1. 786 -25 905 1.00 39 41 H c

ATOM 8976 CZ3 TRP H 162 34 682 -2. 171 -24 725 1.00 39 91 H c

ATOM 8978 CH2 TRP H 162 34 653 -3. 507 -24 290 1.00 40 48 H c

ATOM 8980 CZ2 TRP H 162 34 007 -4. 480 -25 009 1.00 39 65 H c

ATOM 8982 C TRP H 162 31 233 0. 638 -28 928 1.00 40 19 H c

ATOM 8983 0 TRP H 162 31 178 0. 780 -30 151 1.00 40 20 H 0

ATOM 8985 N ASN H 163 31 357 1. 653 -28 070 1.00 39 33 H N

ATOM 8986 CA ASN H 163 31 370 3. 057 -28 498 1.00 41 89 H c

ATOM 8988 CB ASN H 163 32 620 3. 367 -29 339 1.00 40 11 H c

ATOM 8991 CG ASN H 163 33 911 3. 215 -28 569 1.00 38 26 H c

ATOM 8992 001 ASN H 163 33 926 3. 170 -27 342 1.00 36 78 H 0

ATOM 8993 ND2 ASN H 163 35 016 3. 156 -29 301 1.00 39 32 H N

ATOM 8996 C ASN H 163 30 118 3. 421 -29 302 1.00 43 33 H c

ATOM 8997 0 ASN H 163 30 221 3. 864 -30 448 1.00 47 68 H 0

ATOM 8999 N SER H 164 28 946 3. 234 -28 694 1.00 44 23 H N

ATOM 9000 CA SER H 164 27 637 3. 355 -29 373 1.00 45 69 H c

ATOM 9002 CB SER H 164 27 146 4. 807 -29 339 1.00 46 17 H c

ATOM 9005 OG SER H 164 26 996 5. 257 -28 005 1.00 46 29 H 0

ATOM 9007 C SER H 164 27 603 2. 829 -30 819 1.00 47 27 H c

ATOM 9008 0 SER H 164 26 992 3. 442 -31 696 1.00 50 59 H 0

ATOM 9010 N GLY H 165 28 246 1. 692 -31 062 1.00 47 27 H N

ATOM 9011 CA GLY H 165 28 259 1. 074 -32 392 1.00 47 10 H C

ATOM 9014 C GLY H 165 29 407 1. 515 -33 287 1.00 48 35 H C

ATOM 9015 0 GLY H 165 29 586 0. 961 -34 374 1.00 49 52 H 0

ATOM 9017 N ALA H 166 30 186 2. 503 -32 836 1.00 49 45 H N

ATOM 9018 CA ALA H 166 31 331 3. 017 -33 601 1.00 48 41 H C

ATOM 9020 CB ALA H 166 31 922 4. 227 -32 914 1.00 46 76 H C

ATOM 9024 C ALA H 166 32 409 1. 960 -33 793 1.00 48 52 H C

ATOM 9025 0 ALA H 166 33 027 1. 885 -34 857 1.00 48 82 H 0

ATOM 9027 N LEU H 167 32 639 1. 163 -32 751 1.00 48 29 H N

ATOM 9028 CA LEU H 167 33 620 0. 079 -32 782 1.00 49 19 H c

ATOM 9030 CB LEU H 167 34 402 0. 049 -31 464 1.00 47 51 H c

ATOM 9033 CG LEU H 167 35 550 -0. 954 -31 316 1.00 47 32 H c

ATOM 9035 CDl LEU H 167 36 635 -0. 742 -32 372 1.00 46 59 H c

ATOM 9039 CD2 LEU H 167 36 134 -0. 868 -29 914 1.00 45 00 H c cyno D_Fab

ATOM 9043 C LEU H 167 32. 907 -1. ,257 -33. 032 1. 00 50. ,84 H C

ATOM 9044 O LEU H 167 32. ,134 -1. ,724 -32. 191 1. 00 52. ,27 H 0

ATOM 9046 N THR H 168 33. ,138 -1. ,842 -34. 205 1. 00 50. 59 H N

ATOM 9047 CA THR H 168 32. ,535 -3. ,130 -34. 561 1. 00 50. ,34 H C

ATOM 9049 CB THR H 168 31. ,543 -3. ,002 -35. ,742 1. 00 51.41 H C

ATOM 9051 OGl THR H 168 32. ,250 -2. ,610 -36. 923 1. 00 53. ,75 H 0

ATOM 9053 CG2 THR H 168 30. ,451 -1. ,995 -35. 438 1. 00 49. ,48 H c

ATOM 9057 C THR H 168 33. ,576 -4. ,189 -34. 929 1. 00 52. ,27 H c

ATOM 9058 O THR H 168 33. ,372 -5. 373 -34. 655 1. 00 55. ,41 H 0

ATOM 9060 N SER H 169 34. ,671 -3. ,770 -35. 563 1. 00 51. 37 H N

ATOM 9061 CA SER H 169 35. ,729 -4. ,690 -35. 987 1. 00 49. 68 H c

ATOM 9063 CB SER H 169 36. ,619 -4. ,018 -37. 040 1. 00 53. ,49 H c

ATOM 9066 OG SER H 169 37. ,749 -4. ,816 -37. ,347 1. 00 56. 68 H 0

ATOM 9068 C SER H 169 36. ,582 -5. ,176 -34. ,804 1. 00 47. 96 H c

ATOM 9069 O SER H 169 36. ,931 -4. ,403 -33. ,918 1. 00 48. ,63 H 0

ATOM 9071 N GLY H 170 36. ,907 -6. ,470 -34. 803 1. 00 47. 65 H N

ATOM 9072 CA GLY H 170 37. ,636 -7. ,097 -33. 704 1. 00 43. 21 H c

ATOM 9075 C GLY H 170 36. ,758 -7. ,537 -32. 539 1. 00 39. 10 H c

ATOM 9076 O GLY H 170 37. ,227 -8. ,268 -31. 671 1. 00 37. 37 H 0

ATOM 9078 N VAL H 171 35. ,491 -7. ,107 -32. 521 1. 00 36. 51 H N

ATOM 9079 CA VAL H 171 34. ,548 -7. ,432 -31. ,441 1. 00 36. ,21 H c

ATOM 9081 CB VAL H 171 33. ,284 -6. ,518 -31. ,464 1. 00 34. ,32 H c

ATOM 9083 CGI VAL H 171 32. ,200 -7. ,046 -30. ,516 1. 00 34. ,84 H c

ATOM 9087 CG2 VAL H 171 33. ,643 -5. ,078 -31. ,118 1. 00 29. ,74 H c

ATOM 9091 C VAL H 171 34. ,096 -8. ,891 -31. ,532 1. 00 36. 36 H c

ATOM 9092 O VAL H 171 33. ,739 -9. ,374 -32. 604 1. 00 38. 22 H 0

ATOM 9094 N HIS H 172 34. ,143 -9. ,580 -30. 394 1. 00 37. 16 H N

ATOM 9095 CA HIS H 172 33. ,632 -10. ,933 -30. 260 1. 00 31.63 H c

ATOM 9097 CB HIS H 172 34. ,780 -11. ,928 -30. 126 1. 00 30. 84 H c

ATOM 9100 CG HIS H 172 35. ,543 -12. ,152 -31. ,391 1. 00 29. ,89 H c

ATOM 9101 NDl HIS H 172 34. ,947 -12. ,611 -32. ,545 1. 00 31. ,55 H N

ATOM 9103 CEl HIS H 172 35. ,860 -12. ,733 -33. 492 1. 00 31. ,14 H C

ATOM 9105 NE2 HIS H 172 37. 029 -12. ,379 -32. 991 1. 00 32. ,03 H N

ATOM 9107 CD2 HIS H 172 36. 857 -12. ,008 -31. 678 1. 00 31. ,79 H C

ATOM 9109 C HIS H 172 32. 793 -10. ,961 -28. 998 1. 00 30. 29 H c

ATOM 9110 O HIS H 172 33. 321 -10. ,888 -27. ,905 1. 00 28. 68 H 0

ATOM 9112 N THR H 173 31. ,477 -11. ,014 -29. ,153 1. 00 32. 85 H N

ATOM 9113 CA THR H 173 30. ,574 -11. ,195 -28. ,019 1. 00 30. ,63 H c

ATOM 9115 CB THR H 173 29. ,316 -10. ,324 -28. ,173 1. 00 31.25 H c

ATOM 9117 OGl THR H 173 29. ,707 -8. ,946 -28. ,322 1. 00 29. ,82 H 0

ATOM 9119 CG2 THR H 173 28. ,394 -10. ,485 -26. 969 1. 00 28. ,11 H c

ATOM 9123 C THR H 173 30. ,232 -12. ,691 -27. ,986 1. 00 28. ,88 H c

ATOM 9124 O THR H 173 29. ,845 -13. ,258 -29. ,000 1. 00 25. ,13 H 0

ATOM 9126 N PHE H 174 30. ,409 -13, ,325 -26. 829 1. 00 27. ,87 H N

ATOM 9127 CA PHE H 174 30. ,294 -14. ,780 -26. ,721 1. 00 26. ,01 H c

ATOM 9129 CB PHE H 174 31. ,280 -15. ,335 -25. ,686 1. 00 23. ,16 H c

ATOM 9132 CG PHE H 174 32. ,707 -15. .185 -26. ,087 1. 00 22. ,10 H c

ATOM 9133 CDl PHE H 174 33. ,282 -16. .071 -26. ,965 1. 00 22. ,06 H c

ATOM 9135 CEl PHE H 174 34. ,591 -15. .923 -27. ,343 1. 00 24. ,20 H c

ATOM 9137 CZ PHE H 174 35. ,341 -14. ,882 -26. ,868 1. 00 21.23 H c

ATOM 9139 CE2 PHE H 174 34. ,781 -13. ,992 -26. ,012 1. 00 24. 45 H c

ATOM 9141 CD2 PHE H 174 33. ,464 -14. ,139 -25. ,624 1. 00 22. ,54 H c

ATOM 9143 C PHE H 174 28. ,887 -15. ,183 -26. ,343 1. 00 23. 27 H c

ATOM 9144 O PHE H 174 28. ,229 -14. ,471 -25. ,571 1. 00 29. 38 H 0

ATOM 9146 N PRO H 175 28. ,416 -16. ,328 -26. ,876 1. 00 24. ,86 H N

ATOM 9147 CA PRO H 175 27. ,127 -16, ,855 -26. ,466 1. 00 25. ,91 H c

ATOM 9149 CB PRO H 175 27. ,142 -18, .283 -27, .026 1. 00 29. ,50 H c

ATOM 9152 CG PRO H 175 27. ,971 -18, ,179 -28. .263 1. 00 29. ,48 H c

ATOM 9155 CD PRO H 175 29. ,054 -17, .192 -27. ,897 1. 00 29. ,12 H c

ATOM 9158 C PRO H 175 27. ,029 -16. .895 -24. ,960 1. 00 23. ,47 H c

ATOM 9159 0 PRO H 175 27. ,975 -17. .326 -24. ,307 1. 00 17. ,17 H 0

ATOM 9160 N ALA H 176 25. ,914 -16. .423 -24. ,416 1. 00 29. ,78 H N

ATOM 9161 CA ALA H 176 25. ,651 -16. .552 -22. ,981 1. 00 31.63 H c

ATOM 9163 CB ALA H 176 24. .312 -15, .929 -22, .636 1. 00 29. ,92 H c

ATOM 9167 C ALA H 176 25. .666 -18, .035 -22, .608 1. 00 36. ,78 H c

ATOM 9168 O ALA H 176 25. ,227 -18, .887 -23, ,398 1. 00 42. ,01 H 0

ATOM 9170 N VAL H 177 26. ,211 -18, ,340 -21, ,433 1. ,00 38. ,99 H N

ATOM 9171 CA VAL H 177 26. ,134 -19, ,683 -20, ,856 1. ,00 37. ,55 H c cyno fD_Fab

ATOM 9173 CB VAL H 177 27. 535 -20 337 -20 632 1 00 39.73 H C

ATOM 9175 CGI VAL H 177 28. 296 -20 424 -21 949 1 00 42.86 H C

ATOM 9179 CG2 VAL H 177 28. 356 -19 583 -19 576 1 00 43.69 H C

ATOM 9183 C VAL H 177 25. 399 -19 561 -19 542 1 00 34.96 H c

ATOM 9184 O VAL H 177 25. 551 -18 565 -18 842 1 00 36.75 H 0

ATOM 9186 N LEU H 178 24. 585 -20 560 -19 219 1 00 36.02 H N

ATOM 9187 CA LEU H 178 23. 877 -20 581 -17 939 1 00 37.20 H c

ATOM 9189 CB LEU H 178 22. 613 -21 447 -18 006 1 00 35.83 H c

ATOM 9192 CG LEU H 178 21. 592 -21 185 -16 892 1 00 36.22 H c

ATOM 9194 CDl LEU H 178 20. 875 -19 859 -17 116 1 00 34.05 H c

ATOM 9198 CD2 LEU H 178 20. 584 -22 326 -16 785 1 00 36.81 H c

ATOM 9202 C LEU H 178 24. 830 -21 092 -16 862 1 00 37.16 H c

ATOM 9203 O LEU H 178 25. 556 -22 066 -17 071 1 00 38.80 H 0

ATOM 9205 N GLN H 179 24. 842 -20 403 -15 728 1 00 36.47 H N

ATOM 9206 CA GLN H 179 25. 704 -20 752 -14 607 1 00 38.38 H c

ATOM 9208 CB GLN H 179 26. 153 -19 494 -13 859 1 00 37.22 H c

ATOM 9211 CG GLN H 179 26. 936 -18 507 -14 712 1 00 35.37 H c

ATOM 9214 CD GLN H 179 27. 083 -17 156 -14 053 1 00 36.16 H c

ATOM 9215 OEl GLN H 179 26. 099 -16 558 -13 608 1 00 32.55 H 0

ATOM 9216 NE2 GLN H 179 28. 315 -16 655 -14 001 1 00 35.83 H N

ATOM 9219 C GLN H 179 24. 942 -21 652 -13 657 1 00 39.66 H c

ATOM 9220 O GLN H 179 23. 717 -21 757 -13 739 1 00 39.79 H 0

ATOM 9222 N SER H 180 25. 667 -22 279 -12 735 1 00 39.11 H N

ATOM 9223 CA SER H 180 25. 050 -23 176 -11.761 1 00 38.91 H c

ATOM 9225 CB SER H 180 26. 114 -23 761 -10 836 1 00 39.16 H c

ATOM 9228 OG SER H 180 25. 860 -25 134 -10 615 1 00 42.49 H 0

ATOM 9230 C SER H 180 23. 961 -22 440 -10 967 1 00 37.72 H c

ATOM 9231 O SER H 180 22. 995 -23 039 -10 487 1 00 35.14 H 0

ATOM 9233 N SER H 181 24. 135 -21 126 -10 863 1 00 39.95 H N

ATOM 9234 CA SER H 181 23. 162 -20 216 -10 273 1 00 40.21 H c

ATOM 9236 CB SER H 181 23. 768 -18 808 -10 262 1 00 41.56 H c

ATOM 9239 OG SER H 181 22. 832 -17 854 -9 809 1 00 45.06 H 0

ATOM 9241 C SER H 181 21. 793 -20 162 -10 978 1 00 39.65 H c

ATOM 9242 O SER H 181 20. 800 -19 742 -10 371 1 00 36.62 H 0

ATOM 9244 N GLY H 182 21. 739 -20 572 -12 247 1 00 39.36 H N

ATOM 9245 CA GLY H 182 20. 548 -20 375 -13 081 1 00 37.39 H c

ATOM 9248 C GLY H 182 20. 442 -18 941 -13 592 1 00 38.25 H C

ATOM 9249 O GLY H 182 19. 343 -18 460 -13 907 1 00 38.14 H 0

ATOM 9251 N LEU H 183 21. 587 -18 256 -13 655 1 00 37.01 H N

ATOM 9252 CA LEU H 183 21.682 -16 887 -14 168 1 00 34.15 H C

ATOM 9254 CB LEU H 183 22. 129 -15 916 -13 076 1 00 34. 54 H c

ATOM 9257 CG LEU H 183 21. 222 -15 677 -11 876 1 00 33.56 H c

ATOM 9259 CDl LEU H 183 21. 883 -14 688 -10 940 1 00 33.42 H c

ATOM 9263 CD 2 LEU H 183 19. 861 -15 172 -12 313 1 00 36.28 H c

ATOM 9267 C LEU H 183 22. 705 -16 869 -15 295 1 00 33.79 H c

ATOM 9268 O LEU H 183 23. 712 -17 581 -15 240 1 00 32.18 H 0

ATOM 9270 N TYR H 184 22. 453 -16 046 -16 307 1 00 31.66 H N

ATOM 9271 CA TYR H 184 23. 315 -16 006 -17 475 1 00 30.92 H c

ATOM 9273 CB TYR H 184 22. 541 -15 510 -18 720 1 00 34.29 H c

ATOM 9276 CG TYR H 184 21.650 -16 575 -19 328 1 00 33.02 H c

ATOM 9277 CDl TYR H 184 22. 198 -17 611 -20 071 1 00 33.13 H c

ATOM 9279 CEl TYR H 184 21. 402 -18 602 -20 622 1 00 33.68 H c

ATOM 9281 CZ TYR H 184 20. 038 -18 567 -20 427 1 00 33.95 H c

ATOM 9282 OH TYR H 184 19. 263 -19 560 -20 982 1 00 34.13 H 0

ATOM 9284 CE2 TYR H 184 19. 462 -17 549 -19 684 1 00 33.90 H c

ATOM 9286 CD 2 TYR H 184 20. 269 -16 560 -19 137 1 00 32.94 H c

ATOM 9288 C TYR H 184 24. 561 -15 164 -17 228 1 00 26.66 H c

ATOM 9289 O TYR H 184 24. 586 -14 315 -16 340 1 00 23.69 H 0

ATOM 9291 N SER H 185 25. 596 -15 444 -18 014 1 00 24.96 H N

ATOM 9292 CA SER H 185 26. 819 -14 662 -18 025 1 00 27.07 H c

ATOM 9294 CB SER H 185 27. 820 -15 218 -17 014 1 00 31.24 H c

ATOM 9297 OG SER H 185 28. 687 -14 211 -16 526 1 00 29.97 H 0

ATOM 9299 C SER H 185 27. 408 -14 744 -19 417 1 00 26.32 H c

ATOM 9300 O SER H 185 27. 370 -15 795 -20 020 1 00 22.17 H 0

ATOM 9302 N LEU H 186 27. 898 -13 625 -19 940 1 00 26.06 H N

ATOM 9303 CA LEU H 186 28. 757 -13 637 -21 123 1 00 27.04 H c

ATOM 9305 CB LEU H 186 27. 949 -13 451 -22 417 1 00 27.30 H c

ATOM 9308 CG LEU H 186 27. 073 -12 213 -22 628 1 00 26.09 H c cyno fD_Fab

ATOM 9310 CDl LEU H 186 27. .921 -11. 031 -23. ,040 1.00 27.47 H C

ATOM 9314 CD2 LEU H 186 25. ,996 -12. 494 -23. ,688 1.00 27.16 H C

ATOM 9318 C LEU H 186 29. 822 -12. 559 -20. ,987 1.00 29.25 H c

ATOM 9319 O LEU H 186 29. 758 -11. 710 -20. ,098 1.00 28.27 H 0

ATOM 9321 N SER H 187 30. 826 -12. 632 -21.846 1.00 28.56 H N

ATOM 9322 CA SER H 187 31. ,824 -11. 584 -21. 960 1.00 29.45 H c

ATOM 9324 CB SER H 187 33. ,225 -12. 113 -21. 629 1.00 31.43 H c

ATOM 9327 OG SER H 187 33. ,390 -12. 319 -20. ,230 1.00 34.09 H 0

ATOM 9329 C SER H 187 31. ,770 -11. 075 -23. ,396 1.00 29.63 H c

ATOM 9330 O SER H 187 31.396 -11. 807 -24. 308 1.00 22.96 H 0

ATOM 9332 N SER H 188 32. 104 -9. 802 -23. 575 1.00 31.30 H N

ATOM 9333 CA SER H 188 32. 293 -9. 235 -24. 889 1.00 30.41 H c

ATOM 9335 CB SER H 188 31.291 -8. 114 -25. 158 1.00 30.88 H c

ATOM 9338 OG SER H 188 31. 378 -7. 715 -26. 515 1.00 33.80 H 0

ATOM 9340 C SER H 188 33. ,696 -8. 683 -24. 928 1.00 30.01 H c

ATOM 9341 O SER H 188 34. ,050 -7. 844 -24. 121 1.00 29.88 H 0

ATOM 9343 N VAL H 189 34. ,498 -9. 152 -25. 865 1.00 29.49 H N

ATOM 9344 CA VAL H 189 35. ,867 -8. 690 -25. ,953 1.00 30.73 H c

ATOM 9346 CB VAL H 189 36. ,877 -9. 848 -25. ,851 1.00 25.82 H c

ATOM 9348 CGI VAL H 189 36. 718 -10. 576 -24. ,515 1.00 21.43 H c

ATOM 9352 CG2 VAL H 189 36. ,723 -10. 815 -27. 032 1.00 25.88 H c

ATOM 9356 C VAL H 189 36. ,064 -7. 945 -27. ,255 1.00 31.03 H c

ATOM 9357 O VAL H 189 35. 262 -8. 053 -28. 174 1.00 30.72 H 0

ATOM 9359 N VAL H 190 37. 129 -7. 161 -27. 304 1.00 37.49 H N

ATOM 9360 CA VAL H 190 37. 534 -6. 496 -28. 526 1.00 38.09 H c

ATOM 9362 CB VAL H 190 36. 823 -5. 122 -28. 709 1.00 38.25 H c

ATOM 9364 CGI VAL H 190 37. 301 -4. 109 -27. 693 1.00 40.15 H c

ATOM 9368 CG2 VAL H 190 37. 021 -4. 608 -30. 123 1.00 38.47 H c

ATOM 9372 C VAL H 190 39. ,058 -6. 378 -28. 538 1.00 39.18 H c

ATOM 9373 O VAL H 190 39. ,705 -6. 232 -27. 494 1.00 35.47 H 0

ATOM 9375 N THR H 191 39. 617 -6. 492 -29. 735 1.00 39.82 H N

ATOM 9376 CA THR H 191 41. ,046 -6. 412 -29. 940 1.00 40.25 H c

ATOM 9378 CB THR H 191 41. ,528 -7. 660 -30. 733 1.00 41.71 H c

ATOM 9380 OGl THR H 191 42. ,788 -8. 091 -30. 225 1.00 43.68 H 0

ATOM 9382 CG2 THR H 191 41. 623 -7. 401 -32. 238 1.00 43.13 H c

ATOM 9386 C THR H 191 41.329 -5. 071 -30. 641 1.00 40.06 H c

ATOM 9387 O THR H 191 40. 665 -4. 725 -31.631 1.00 37.80 H 0

ATOM 9389 N VAL H 192 42. 265 -4. 293 -30. 088 1.00 42.79 H N

ATOM 9390 CA VAL H 192 42. ,561 -2. 935 -30. 583 1.00 43.28 H c

ATOM 9392 CB VAL H 192 41. ,786 -1. 850 -29. ,780 1.00 39.99 H c

ATOM 9394 CGI VAL H 192 40. ,281 -2. 119 -29. ,818 1.00 36.90 H c

ATOM 9398 CG2 VAL H 192 42. ,297 -1. 765 -28. ,336 1.00 37.65 H c

ATOM 9402 C VAL H 192 44. ,073 -2. 629 -30. 538 1.00 46.49 H c

ATOM 9403 O VAL H 192 44. ,816 -3. 319 -29. 848 1.00 46.83 H 0

ATOM 9405 N PRO H 193 44. ,533 -1. 598 -31. 278 1.00 49.11 H N

ATOM 9406 CA PRO H 193 45. ,952 -1. 249 -31. ,233 1.00 48.46 H c

ATOM 9408 CB PRO H 193 46. ,068 -0. 093 -32. ,236 1.00 50.63 H c

ATOM 9411 CG PRO H 193 44. ,853 -0. 167 -33. 079 1.00 50.70 H c

ATOM 9414 CD PRO H 193 43. 788 -0. 720 -32. 200 1.00 51.30 H c

ATOM 9417 C PRO H 193 46. ,391 -0. 782 -29. ,853 1.00 49.46 H c

ATOM 9418 O PRO H 193 45. ,711 0. 041 -29. ,242 1.00 49.52 H 0

ATOM 9419 N SER H 194 47. ,524 -1. 292 -29. ,376 1.00 50.04 H N

ATOM 9420 CA SER H 194 48. 049 -0. 923 -28. ,060 1.00 52.64 H c

ATOM 9422 CB SER H 194 49. 153 -1. 895 -27. ,648 1.00 54.75 H c

ATOM 9425 OG SER H 194 50. ,029 -2. 135 -28. ,732 1.00 58.42 H 0

ATOM 9427 C SER H 194 48. 561 0. 530 -28. ,002 1.00 54.25 H c

ATOM 9428 O SER H 194 48. ,720 1. 094 -26. ,919 1.00 53.05 H 0

ATOM 9430 N SER H 195 48. ,823 1. 118 -29. ,169 1.00 54.90 H N

ATOM 9431 CA SER H 195 49. ,124 2. 539 -29. ,281 1.00 53.83 H c

ATOM 9433 CB SER H 195 49. ,516 2. 893 -30. ,724 1.00 53.59 H c

ATOM 9436 OG SER H 195 48. ,427 2. ,715 -31. ,620 1.00 51.84 H 0

ATOM 9438 C SER H 195 47. 920 3. 383 -28. ,856 1.00 55.17 H c

ATOM 9439 O SER H 195 48. ,086 4. 441 -28. ,243 1.00 57.09 H 0

ATOM 9441 N SER H 196 46. ,715 2. 903 -29. ,169 1.00 52.07 H N

ATOM 9442 CA SER H 196 45. ,484 3. 678 -28. ,966 1.00 51.60 H c

ATOM 9444 CB SER H 196 44. 396 3. 196 -29. ,927 1.00 49.97 H c

ATOM 9447 OG SER H 196 43. ,749 2. 048 -29. ,409 1.00 49.21 H 0

ATOM 9449 C SER H 196 44. ,921 3. 645 -27. ,540 1.00 50.21 H c cyno fD_Fab

ATOM 9450 O SER H 196 43, ,903 4. 273 -27. 273 1.00 49. ,96 H 0

ATOM 9452 N LEU H 197 45. ,560 2. 913 -26. 635 1.00 50. ,19 H N

ATOM 9453 CA LEU H 197 45. ,056 2. 798 -25. 269 1.00 49. ,85 H C

ATOM 9455 CB LEU H 197 45. ,903 1. 811 -24. 456 1.00 50. ,12 H C

ATOM 9458 CG LEU H 197 45. ,521 0. 322 -24. 553 1.00 50. ,11 H C

ATOM 9460 CDl LEU H 197 45. ,037 -0. 081 -25. 938 1.00 47. ,91 H C

ATOM 9464 CD 2 LEU H 197 46. ,693 -0. 555 -24. 118 1.00 49. ,12 H c

ATOM 9468 C LEU H 197 44. ,976 4. 160 -24. 569 1.00 50, ,90 H c

ATOM 9469 O LEU H 197 43. ,951 4. 485 -23. 978 1.00 51. ,36 H 0

ATOM 9471 N GLY H 198 46. 042 4. 956 -24. 649 1.00 50. ,28 H N

ATOM 9472 CA GLY H 198 46. 054 6. 296 -24. 049 1.00 48. ,80 H C

ATOM 9475 C GLY H 198 45. 179 7. 328 -24. 757 1.00 47. ,41 H c

ATOM 9476 O GLY H 198 44. 683 8. 264 -24. 131 1.00 44. 62 H 0

ATOM 9478 N THR H 199 44. 996 7. 152 -26. 063 1.00 48. ,80 H N

ATOM 9479 CA THR H 199 44. 210 8. 070 -26. 893 1.00 48. ,64 H C

ATOM 9481 CB THR H 199 44. ,681 8. 005 -28. 368 1.00 51, ,11 H C

ATOM 9483 OGl THR H 199 46. ,031 8. 473 -28. 465 1.00 54. ,24 H 0

ATOM 9485 CG2 THR H 199 43. ,789 8. 850 -29. 262 1.00 52. .40 H C

ATOM 9489 C THR H 199 42. ,712 7. 755 -26. 863 1.00 47. 77 H C

ATOM 9490 O THR H 199 41. ,911 8. 552 -26. 380 1.00 44. ,62 H 0

ATOM 9492 N GLN H 200 42. 351 6. 582 -27. 384 1.00 47. 14 H N

ATOM 9493 CA GLN H 200 40. ,955 6. 209 -27. 621 1.00 46. ,51 H C

ATOM 9495 CB GLN H 200 40. 895 5. 138 -28. 717 1.00 44. ,42 H C

ATOM 9498 CG GLN H 200 39. 499 4. 738 -29. 182 1.00 45. 90 H c

ATOM 9501 CD GLN H 200 38. ,848 5. 762 -30. 098 1.00 45. ,82 H c

ATOM 9502 OEl GLN H 200 38. ,205 6. 700 -29. 635 1.00 47. ,41 H 0

ATOM 9503 NE2 GLN H 200 38. ,985 5. 565 -31.405 1.00 42. ,97 H N

ATOM 9506 C GLN H 200 40. ,243 5. 710 -26. 357 1.00 45. ,65 H c

ATOM 9507 O GLN H 200 40. ,792 4. 933 -25. 572 1.00 43. ,98 H 0

ATOM 9509 N THR H 201 39. 005 6. 161 -26. 189 1.00 47. ,58 H N

ATOM 9510 CA THR H 201 38. 143 5. 726 -25. 095 1.00 47. ,21 H c

ATOM 9512 CB THR H 201 37. 309 6. 911 -24. 540 1.00 48. ,57 H c

ATOM 9514 OGl THR H 201 36. 771 6. 566 -23. 259 1.00 50. ,58 H 0

ATOM 9516 CG2 THR H 201 36. ,175 7. 288 -25. 489 1.00 49. ,30 H c

ATOM 9520 C THR H 201 37. ,229 4. 580 -25. 568 1.00 48. ,00 H c

ATOM 9521 O THR H 201 36. ,686 4. 615 -26. 684 1.00 51. ,43 H 0

ATOM 9523 N TYR H 202 37. ,081 3. 559 -24. 724 1.00 44. ,88 H N

ATOM 9524 CA TYR H 202 36. 286 2. 372 -25. 058 1.00 39. ,70 H c

ATOM 9526 CB TYR H 202 37. ,185 1. 140 -25. 124 1.00 35. ,33 H c

ATOM 9529 CG TYR H 202 38. 255 1. 254 -26. 172 1.00 34. ,47 H c

ATOM 9530 CDl TYR H 202 37. 925 1. 257 -27. 518 1.00 34. ,73 H c

ATOM 9532 CEl TYR H 202 38. 895 1. 373 -28. 497 1.00 34. ,69 H c

ATOM 9534 CZ TYR H 202 40. ,221 1. 482 -28. 132 1.00 34. ,96 H c

ATOM 9535 OH TYR H 202 41. ,177 1. 593 -29. ,119 1.00 36. ,42 H 0

ATOM 9537 CE2 TYR H 202 40. ,583 1. 480 -26. 792 1.00 35. ,40 H c

ATOM 9539 CD2 TYR H 202 39. 597 1. 370 -25. 821 1.00 34, ,99 H c

ATOM 9541 C TYR H 202 35. 197 2. 152 -24. 022 1.00 36. ,55 H c

ATOM 9542 O TYR H 202 35. ,485 1. 823 -22. 869 1.00 34. ,23 H 0

ATOM 9544 N ILE H 203 33. 950 2. 356 -24. 432 1.00 36. ,39 H N

ATOM 9545 CA ILE H 203 32. 796 2. 077 -23. 580 1.00 37. ,78 H c

ATOM 9547 CB ILE H 203 31. 865 3. ,303 -23. 431 1.00 39. ,65 H c

ATOM 9549 CGI ILE H 203 32. ,619 4. ,490 -22. ,816 1.00 42. ,19 H c

ATOM 9552 CDl ILE H 203 33. ,625 5. ,152 -23. ,748 1.00 44. ,25 H c

ATOM 9556 CG2 ILE H 203 30. ,655 2. 953 -22. ,571 1.00 36. ,04 H c

ATOM 9560 C ILE H 203 32. ,008 0. 916 -24. ,181 1.00 35. ,64 H c

ATOM 9561 O ILE H 203 31. ,814 0. 857 -25. 399 1.00 36. ,87 H 0

ATOM 9563 N CYS H 204 31. ,578 -0. 017 -23. 334 1.00 34. ,14 H N

ATOM 9564 CA CYS H 204 30. ,712 -1. 102 -23. 782 1.00 35. ,14 H c

ATOM 9566 CB CYS H 204 31. ,141 -2. 470 -23. 221 1.00 35. ,57 H c

ATOM 9569 SG CYS H 204 30. ,976 -2. 706 -21. 433 1.00 36. ,48 H s

ATOM 9571 C CYS H 204 29. ,272 -0. ,764 -23. ,415 1.00 33. ,78 H c

ATOM 9572 O CYS H 204 28. ,963 -0. ,446 -22. ,262 1.00 31. ,37 H 0

ATOM 9574 N ASN H 205 28. ,406 -0. ,818 -24. 422 1.00 32. ,13 H N

ATOM 9575 CA ASN H 205 27. ,006 -0. ,466 -24. ,265 1.00 34. ,14 H C

ATOM 9577 CB ASN H 205 26. ,497 0. 346 -25. ,468 1.00 32. ,25 H C

ATOM 9580 CG ASN H 205 27. ,581 1. 213 -26. ,101 1.00 30. ,36 H C

ATOM 9581 OOl ASN H 205 28. ,058 2. 172 -25. ,500 1.00 30. ,91 H 0

ATOM 9582 ND2 ASN H 205 27. ,968 0. 873 -27. ,322 1.00 29. ,84 H N cyno fD_Fab

ATOM 9585 C ASN H 205 26. ,227 -1. ,761 -24. 119 1.00 35. 10 H C

ATOM 9586 O ASN H 205 26. ,039 -2. 500 -25. 095 1.00 37. 58 H 0

ATOM 9588 N VAL H 206 25. 825 -2. ,048 -22. 886 1.00 33. 48 H N

ATOM 9589 CA VAL H 206 25. ,077 -3. 250 -22. 561 1.00 34. 28 H C

ATOM 9591 CB VAL H 206 25. 601 -3. 891 -21. 249 1.00 33. 76 H C

ATOM 9593 CGl VAL H 206 24. 809 -5. 158 -20. 909 1.00 31. 24 H C

ATOM 9597 CG2 VAL H 206 27. ,097 -4. ,189 -21. 367 1.00 29. 08 H C

ATOM 9601 C VAL H 206 23. ,609 -2. ,880 -22. 388 1.00 34. 22 H c

ATOM 9602 O VAL H 206 23. ,291 -1. ,995 -21. 599 1.00 26. 04 H 0

ATOM 9604 N ASN H 207 22. ,724 -3. ,547 -23. 134 1.00 35. 45 H N

ATOM 9605 CA ASN H 207 21. 279 -3. ,390 -22. 943 1.00 38. 10 H c

ATOM 9607 CB ASN H 207 20. ,614 -2. 859 -24. 220 1.00 43. 60 H c

ATOM 9610 CG ASN H 207 19. 430 -1. 934 -23. 932 1.00 47. 66 H c

ATOM 9611 001 ASN H 207 18. 623 -2. 177 -23. 025 1.00 48. 62 H 0

ATOM 9612 ND2 ASN H 207 19. 322 -0. 866 -24. 715 1.00 50. 96 H N

ATOM 9615 C ASN H 207 20. 625 -4. 709 -22. 523 1.00 36. 03 H C

ATOM 9616 0 ASN H 207 20. 903 -5. 758 -23. 089 1.00 30. 00 H 0

ATOM 9618 N HIS H 208 19. 766 -4. ,645 -21. 511 1.00 36. 32 H N

ATOM 9619 CA HIS H 208 18. 966 -5. ,794 -21.090 1.00 36. ,55 H C

ATOM 9621 CB HIS H 208 19. 536 -6. 377 -19. 790 1.00 34. 97 H C

ATOM 9624 CG HIS H 208 18. 887 -7. 652 -19. 354 1.00 34. 50 H c

ATOM 9625 NDl HIS H 208 18. 871 -8. ,785 -20. 137 1.00 35. 85 H N

ATOM 9627 CEl HIS H 208 18. 234 -9. 748 -19. 498 1.00 34. 42 H c

ATOM 9629 NE2 HIS H 208 17. 850 -9. 288 -18. 321 1.00 34. 44 H N

ATOM 9631 CD2 HIS H 208 18. 250 -7. 981 -18. 205 1.00 33. 47 H C

ATOM 9633 C HIS H 208 17. 495 -5. 348 -20. 946 1.00 36. 02 H C

ATOM 9634 0 HIS H 208 17. 093 -4. 825 -19. 907 1.00 31. 60 H 0

ATOM 9636 N LYS H 209 16. 717 -5. 550 -22. 013 1.00 36. 40 H N

ATOM 9637 CA LYS H 209 15. 322 -5. 094 -22. 088 1.00 39. ,34 H C

ATOM 9639 CB LYS H 209 14. 723 -5. 362 -23. 478 1.00 40. ,78 H c

ATOM 9642 CG LYS H 209 15. 095 -4. 345 -24. 557 1.00 42. 53 H c

ATOM 9645 CD LYS H 209 14. 731 -4. 862 -25. 953 1.00 42. 18 H c

ATOM 9648 CE LYS H 209 15. 193 -3. 922 -27. 067 1.00 43. 81 H c

ATOM 9651 NZ LYS H 209 15. 378 -4. 642 -28. 368 1.00 42. 37 H N

ATOM 9655 C LYS H 209 14. 381 -5. 682 -21. 029 1.00 39. 21 H c

ATOM 9656 0 LYS H 209 13. 537 -4. 960 -20. 516 1.00 38. 49 H 0

ATOM 9658 N PRO H 210 14. 486 -6. 995 -20. 734 1.00 40. 00 H N

ATOM 9659 CA PRO H 210 13. 590 -7. 612 -19. 745 1.00 40. 15 H c

ATOM 9661 CB PRO H 210 14. ,137 -9. 037 -19. 619 1.00 38. 91 H c

ATOM 9664 CG PRO H 210 14. ,787 -9. 297 -20. 910 1.00 37. 78 H c

ATOM 9667 CD PRO H 210 15. 393 -7. ,994 -21. 325 1.00 37. 78 H c

ATOM 9670 C PRO H 210 13. 564 -6. 940 -18. 377 1.00 42. 64 H c

ATOM 9671 0 PRO H 210 12. 498 -6. ,859 -17. 761 1.00 43. 72 H 0

ATOM 9672 N SER H 211 14. 720 -6. ,478 -17. 906 1.00 43. 72 H N

ATOM 9673 CA SER H 211 14. 808 -5. 760 -16. 632 1.00 43. 75 H c

ATOM 9675 CB SER H 211 16. 027 -6. 222 -15. 841 1.00 43. 73 H c

ATOM 9678 OG SER H 211 17. 226 -5. 828 -16. 485 1.00 43. 23 H 0

ATOM 9680 C SER H 211 14. 887 -4. ,253 -16. ,844 1.00 45. 26 H c

ATOM 9681 0 SER H 211 14. 859 -3. 495 -15. 878 1.00 43. 07 H 0

ATOM 9683 N ASN H 212 14. 984 -3. ,822 -18. 102 1.00 46. ,57 H N

ATOM 9684 CA ASN H 212 15. ,077 -2. ,402 -18. 433 1.00 47. 42 H c

ATOM 9686 CB ASN H 212 13. ,867 -1. ,635 -17. ,842 1.00 49. 69 H c

ATOM 9689 CG ASN H 212 13. 478 -0. ,403 -18. 655 1.00 50. ,40 H c

ATOM 9690 ODl ASN H 212 13. 703 -0. ,337 -19. ,867 1.00 54. 65 H 0

ATOM 9691 ND2 ASN H 212 12. 865 0. ,568 -17. 989 1.00 51. 36 H N

ATOM 9694 C ASN H 212 16. 410 -1. ,831 -17. 929 1.00 47. ,98 H c

ATOM 9695 0 ASN H 212 16. 453 -0. ,766 -17. 303 1.00 47. 48 H 0

ATOM 9697 N THR H 213 17. 494 -2. ,560 -18. 193 1.00 46. ,12 H N

ATOM 9698 CA THR H 213 18. 836 -2. ,130 -17. 805 1.00 46. 73 H c

ATOM 9700 CB THR H 213 19. 696 -3. ,305 -17. 298 1.00 46. ,85 H c

ATOM 9702 OGl THR H 213 19. 026 -3. ,965 -16. ,220 1.00 47. ,58 H 0

ATOM 9704 CG2 THR H 213 21. 048 -2. ,815 -16. ,806 1.00 47. ,12 H c

ATOM 9708 C THR H 213 19. ,547 -1. ,501 -18. ,994 1.00 46. ,65 H c

ATOM 9709 0 THR H 213 19. 424 -1. ,974 -20. ,124 1.00 44. ,64 H 0

ATOM 9711 N LYS H 214 20. 283 -0. ,428 -18. ,724 1.00 47. ,98 H N

ATOM 9712 CA LYS H 214 21. 147 0. ,204 -19. ,714 1.00 49. ,55 H c

ATOM 9714 CB LYS H 214 20. 443 1. ,411 -20. ,355 1.00 54. ,40 H c

ATOM 9717 CG LYS H 214 20. 610 1. ,519 -21. ,876 1.00 56. 26 H c cyno fD_Fab

ATOM 9720 CD LYS H 214 22. 076 1. 619 -22. 322 1.00 57. 59 H C

ATOM 9723 CE LYS H 214 22. 204 1. 567 -23. 850 1.00 57. 70 H C

ATOM 9726 NZ LYS H 214 23. 594 1. 832 -24. 322 1.00 57. 48 H N

ATOM 9730 C LYS H 214 22. 424 0. 629 -18. 991 1.00 48. 04 H C

ATOM 9731 O LYS H 214 22. .390 1. 522 -18. 149 1.00 47. 50 H 0

ATOM 9733 N VAL H 215 23. 538 -0. 036 -19. 297 1.00 46. 44 H N

ATOM 9734 CA VAL H 215 24. ,801 0. 213 -18. 600 1.00 45. 66 H C

ATOM 9736 CB VAL H 215 25. ,198 -0. 978 -17. 694 1.00 43. 78 H C

ATOM 9738 CGI VAL H 215 26. ,599 -0. 790 -17. 127 1.00 42. 93 H C

ATOM 9742 CG2 VAL H 215 24. 193 -1. 147 -16. 568 1.00 44. 07 H c

ATOM 9746 C VAL H 215 25. 910 0. 477 -19. 605 1.00 45. 12 H c

ATOM 9747 O VAL H 215 26. 222 -0. 378 -20. 430 1.00 47. 07 H 0

ATOM 9749 N ASP H 216 26. ,494 1. 668 -19. 532 1.00 45. 31 H N

ATOM 9750 CA ASP H 216 27. ,629 2. 034 -20. 366 1.00 45. 40 H c

ATOM 9752 CB ASP H 216 27. ,395 3. 395 -21.022 1.00 47. 46 H c

ATOM 9755 CG ASP H 216 26. ,442 3. 317 -22. 202 1.00 51. 27 H c

ATOM 9756 ODl ASP H 216 25. ,317 3. 853 -22. 099 1.00 55. 80 H 0

ATOM 9757 OD2 ASP H 216 26. ,813 2. 713 -23. 232 1.00 51.16 H 0

ATOM 9758 C ASP H 216 28. 874 2. 060 -19. 493 1.00 45. 86 H c

ATOM 9759 O ASP H 216 29. 077 3. 003 -18. 724 1.00 47. 40 H 0

ATOM 9761 N LYS H 217 29. 694 1. 014 -19. 599 1.00 45. 23 H N

ATOM 9762 CA LYS H 217 30. ,909 0. 884 -18. 787 1.00 44. 11 H c

ATOM 9764 CB LYS H 217 31. ,039 -0. 536 -18. 215 1.00 45. 21 H c

ATOM 9767 CG LYS H 217 31. ,840 -0. 623 -16. 896 1.00 45. 31 H c

ATOM 9770 CD LYS H 217 30. 948 -0. 338 -15. 680 1.00 46. 34 H c

ATOM 9773 CE LYS H 217 31. 671 -0. 555 -14. 368 1.00 47. 49 H c

ATOM 9776 NZ LYS H 217 32. 317 0. 691 -13. 844 1.00 49. 31 H N

ATOM 9780 C LYS H 217 32. 145 1. 223 -19. 617 1.00 41. 31 H c

ATOM 9781 O LYS H 217 32. 324 0. 697 -20. 720 1.00 33. 85 H 0

ATOM 9783 N LYS H 218 32. ,979 2. 110 -19. 075 1.00 41. 50 H N

ATOM 9784 CA LYS H 218 34. ,271 2. 451 -19. 665 1.00 43. 00 H c

ATOM 9786 CB LYS H 218 34. 733 3. 836 -19. 178 1.00 43. 94 H c

ATOM 9789 CG LYS H 218 36. 054 4. 359 -19. 774 1.00 43. 12 H c

ATOM 9792 CD LYS H 218 36. 530 5. 590 -18. 992 1.00 45. 50 H c

ATOM 9795 CE LYS H 218 37. 821 6. 222 -19. 547 1.00 46. 28 H c

ATOM 9798 NZ LYS H 218 38. 435 7. 213 -18. 577 1.00 43. 55 H N

ATOM 9802 C LYS H 218 35. 273 1. 383 -19. 252 1.00 41. 55 H c

ATOM 9803 O LYS H 218 35. ,274 0. 947 -18. 101 1.00 38. 50 H 0

ATOM 9805 N VAL H 219 36. ,110 0. 959 -20. 197 1.00 42. 56 H N

ATOM 9806 CA VAL H 219 37. ,134 -0. 050 -19. 934 1.00 42. 78 H c

ATOM 9808 CB VAL H 219 36. ,937 -1. 324 -20. 788 1.00 36. 43 H c

ATOM 9810 CGI VAL H 219 37. 850 -2. 420 -20. 282 1.00 34. 30 H c

ATOM 9814 CG2 VAL H 219 35. ,495 -1. 782 -20. 742 1.00 33. 17 H c

ATOM 9818 C VAL H 219 38. 522 0. 516 -20. 208 1.00 43. 97 H c

ATOM 9819 O VAL H 219 38. 885 0. 783 -21. 357 1.00 42. 87 H 0

ATOM 9821 N GLU H 220 39. 304 0. 662 -19. 145 1.00 46. 37 H N

ATOM 9822 CA GLU H 220 40. ,593 1. 329 -19. 228 1.00 50. ,43 H c

ATOM 9824 CB GLU H 220 40. ,500 2. 722 -18. 603 1.00 51. 55 H c

ATOM 9827 CG GLU H 220 39. ,891 2. 750 -17. 200 1.00 53. 31 H c

ATOM 9830 CD GLU H 220 39. ,661 4. 155 -16. 677 1.00 54. 48 H c

ATOM 9831 OEl GLU H 220 39. ,765 5. 120 -17. 464 1.00 57. 13 H 0

ATOM 9832 OE2 GLU H 220 39. ,369 4. 294 -15. 470 1.00 55. 85 H 0

ATOM 9833 C GLU H 220 41. 674 0. 507 -18. 538 1.00 50. 59 H c

ATOM 9834 O GLU H 220 41. ,364 -0. 283 -17. 644 1.00 50. 30 H 0

ATOM 9836 N PRO H 221 42. ,947 0. 684 -18. 960 1.00 52. 89 H N

ATOM 9837 CA PRO H 221 44. ,087 0. 041 -18. ,304 1.00 54. ,91 H c

ATOM 9839 CB PRO H 221 45. ,303 0. 653 -19. 013 1.00 53. 94 H c

ATOM 9842 CG PRO H 221 44. ,808 1. 140 -20. 302 1.00 53. 01 H c

ATOM 9845 CD PRO H 221 43. ,373 1. 510 -20. ,107 1.00 53. 35 H c

ATOM 9848 C PRO H 221 44. ,142 0. 372 -16. 819 1.00 56. 11 H c

ATOM 9849 O PRO H 221 43. ,910 1. 519 -16. 449 1.00 55. 83 H 0

ATOM 9850 N LYS H 222 44. ,438 -0. 620 -15. 983 1.00 59. 29 H N

ATOM 9851 CA LYS H 222 44. , 555 -0. 389 -14. ,539 1.00 62. 16 H c

ATOM 9853 CB LYS H 222 44. .428 -1. 700 -13. ,751 1.00 64. ,18 H c

ATOM 9856 CG LYS H 222 43. ,021 -1. 984 -13. ,230 1.00 65. 03 H c

ATOM 9859 CD LYS H 222 43. 057 -2. 728 -11. ,898 1.00 64. 95 H c

ATOM 9862 CE LYS H 222 43. 390 -1. 787 -10. 741 1.00 65. ,52 H c

ATOM 9865 NZ LYS H 222 43. ,536 -2. 515 -9. ,454 1.00 65. 67 H N cyno fD_Fab

ATOM 9869 C LYS H 222 45. ,877 0. 295 -14. ,197 1.00 64. 49 H C

ATOM 9870 O LYS H 222 46. ,949 -0. 256 -14. 444 1.00 66. 76 H 0

ATOM 9872 N ILE B 16 37. ,740 -46. 441 -92. 900 1.00 25. 44 B N

ATOM 9873 CA ILE B 16 39. ,099 -45. 944 -92. ,536 1.00 27. 26 B C

ATOM 9875 CB ILE B 16 40. ,140 -46. 281 -93. ,651 1.00 22. 90 B C

ATOM 9877 CGI ILE B 16 40. ,364 -47. 802 -93. ,774 1.00 21. 87 B C

ATOM 9880 CDl ILE B 16 40. 973 -48. 473 -92. ,567 1.00 20. 02 B c

ATOM 9884 CG2 ILE B 16 41. ,485 -45. 579 -93. ,430 1.00 17. 84 B c

ATOM 9888 C ILE B 16 39. ,048 -44. 424 -92. 294 1.00 31. 54 B c

ATOM 9889 O ILE B 16 38. 798 -43. 663 -93. 228 1.00 29. 23 B 0

ATOM 9893 N LEU B 17 39. ,281 -44. 003 -91.039 1.00 31. 68 B N

ATOM 9894 CA LEU B 17 39. ,487 -42. 589 -90. ,691 1.00 29. 30 B c

ATOM 9896 CB LEU B 17 39. ,167 -42. 308 -89. ,217 1.00 28. 35 B c

ATOM 9899 CG LEU B 17 39. ,747 -40. 994 -88. ,653 1.00 31. 53 B c

ATOM 9901 CDl LEU B 17 39. ,782 -40. 958 -87. ,112 1.00 26. 18 B c

ATOM 9905 CD2 LEU B 17 39. ,010 -39. 774 -89. 199 1.00 30. 41 B c

ATOM 9909 C LEU B 17 40. 931 -42. 182 -90. 950 1.00 31.79 B c

ATOM 9910 O LEU B 17 41. ,848 -42. 898 -90. 565 1.00 31. 22 B 0

ATOM 9912 N GLY B 18 41. ,123 -41.027 -91. 591 1.00 33. 28 B N

ATOM 9913 CA GLY B 18 42. 432 -40. 383 -91. 663 1.00 30. 51 B c

ATOM 9916 C GLY B 18 43. ,394 -40. 929 -92. 692 1.00 33. 23 B c

ATOM 9917 O GLY B 18 44. ,611 -40. 714 -92. ,589 1.00 31. 68 B 0

ATOM 9919 N GLY B 19 42. ,864 -41. 623 -93. 694 1.00 35. 58 B N

ATOM 9920 CA GLY B 19 43. ,698 -42. 179 -94. 750 1.00 36. 21 B c

ATOM 9923 C GLY B 19 43. ,545 -41. 485 -96. 086 1.00 37. 50 B c

ATOM 9924 O GLY B 19 43. 090 -40. 345 -96. 167 1.00 36. 36 B 0

ATOM 9926 N ARG B 20 43. ,961 -42. 192 -97. 130 1.00 39. 95 B N

ATOM 9927 CA ARG B 20 43. 799 -41. 764 -98. 520 1.00 43. 76 B C

ATOM 9929 CB ARG B 20 45. 145 -41. 318 -99. 100 1.00 47. 17 B C

ATOM 9932 CG ARG B 20 45. ,663 -39. 976 -98. 589 1.00 52. 03 B C

ATOM 9935 CD ARG B 20 47. ,189 -39. 873 -98. 754 1.00 53. 23 B C

ATOM 9938 NE ARG B 20 47. ,655 -40. 208- 100. 107 1.00 57. 29 B N

ATOM 9940 CZ ARG B 20 48. 939 -40. 305- 100. 466 1.00 57. 53 B c

ATOM 9941 NHl ARG B 20 49. ,914 -40. 092 -99. 583 1.00 60. 12 B N

ATOM 9944 NH2 ARG B 20 49. 258 -40. 613- 101. 719 1.00 57. 77 B N

ATOM 9947 C ARG B 20 43. 276 -42. 949 -99. 339 1.00 42. 11 B c

ATOM 9948 O ARG B 20 43. 316 -44. 100 -98. 884 1.00 35. 76 B 0

ATOM 9950 N GLU B 21 42. ,799 -42. 667- 100. ,546 1.00 44. 21 B N

ATOM 9951 CA GLU B 21 42. ,431 -43. 725- 101. ,483 1.00 43. 86 B C

ATOM 9953 CB GLU B 21 41. 935 -43. 136- 102. ,804 1.00 43. 96 B c

ATOM 9956 CG GLU B 21 41. 593 -44. 182- 103. ,871 1.00 44. 58 B c

ATOM 9959 CD GLU B 21 40. 995 -43. 578- ^• 105. 132 1.00 44. 42 B c

ATOM 9960 OEl GLU B 21 40. 356 -42. 506- 105. 046 1.00 48. 25 B 0

ATOM 9961 OE2 GLU B 21 41. 161 -44. 183- 106. 208 1.00 44. 53 B 0

ATOM 9962 C GLU B 21 43. 624 -44. 638- 101.730 1.00 42. 83 B c

ATOM 9963 O GLU B 21 44. 755 -44. 170- 101. 883 1.00 42. 95 B 0

ATOM 9965 N ALA B 22 43. ,361 -45. 942- ^■ 101.763 1.00 44. ,73 B N

ATOM 9966 CA ALA B 22 44. ,398 -46. 933- 102. ,006 1.00 44. ,29 B c

ATOM 9968 CB ALA B 22 43. ,941 -48. 314- 101.532 1.00 43. 86 B c

ATOM 9972 C ALA B 22 44. ,761 -46. 977- 103. ,486 1.00 47. 13 B c

ATOM 9973 O ALA B 22 43. 900 -46. 863- ^• 104. 356 1.00 49. 13 B 0

ATOM 9975 N GLU B 23 46. ,055 -47. 106- 103. ,755 1.00 45. 62 B N

ATOM 9976 CA GLU B 23 46. ,556 -47. 438- 105. ,082 1.00 45. 94 B C

ATOM 9978 CB GLU B 23 48. ,086 -47. 632- ^• 105. 037 1.00 48. 26 B C

ATOM 9981 CG GLU B 23 48. ,633 -48. 541- 103. 884 1.00 51. 48 B c

ATOM 9984 CD GLU B 23 48. ,945 -47. 813- ^• 102. ,554 1.00 51. ,54 B c

ATOM 9985 OEl GLU B 23 48. ,041 -47. 168- ^• 101.974 1.00 51. ,14 B 0

ATOM 9986 OE2 GLU B 23 50. ,094 -47. 924- ^• 102. 073 1.00 53. ,70 B 0

ATOM 9987 C GLU B 23 45. ,825 -48. 699- 105. 597 1.00 45. ,66 B c

ATOM 9988 O GLU B 23 45. ,889 -49. 756- 104. 968 1.00 43. ,12 B 0

ATOM 9990 N ALA B 24 45. ,124 -48. 573- 106. 726 1.00 43. 66 B N

ATOM 9991 CA ALA B 24 44. ,090 -49. 550- 107. 123 1.00 43. ,72 B c

ATOM 9993 CB ALA B 24 43. ,303 -49. 032- 108. ,321 1.00 46. 29 B c

ATOM 9997 C ALA B 24 44. ,638 -50. 943- 107. ,421 1.00 42. ,34 B c

ATOM 9998 O ALA B 24 45. ,588 -51. 087- ^• 108. ,192 1.00 44. ,36 B 0

ATOM 10000 N HIS B 25 44. ,024 -51. 955- ^• 106. ,799 1.00 41. 10 B N

ATOM 10001 CA HIS B 25 44. ,450 -53. 370- ^• 106. ,893 1.00 41.44 B c

ATOM 10003 CB HIS B 25 44. ,211 -53. 916- ^• 108. ,313 1.00 42. 00 B c cym fD_Fab

ATOM 10006 CG HIS B 25 42. ,789 -53. 804- 108. 776 1.00 42. ,94 B C

ATOM 10007 NDl HIS B 25 42. ,404 -52. 984- 109. ,815 1.00 42. ,34 B N

ATOM 10009 CEl HIS B 25 41. ,100 -53. 091- 109. ,997 1.00 42. 23 B C

ATOM 10011 NE2 HIS B 25 40. ,623 -53. 944- 109. 111 1.00 43. ,22 B N

ATOM 10013 CD2 HIS B 25 41. ,659 -54. 408- 108. 337 1.00 43. ,34 B C

ATOM 10015 C HIS B 25 45. ,905 -53. 655- 106. ,444 1.00 41. ,05 B C

ATOM 10016 O HIS B 25 46. ,492 -54. 669- 106. ,837 1.00 39. ,79 B 0

ATOM 10018 N ALA B 26 46. ,467 -52. 777- 105. 606 1.00 40. ,97 B N

ATOM 10019 CA ALA B 26 47. 825 -52. 955- 105. 063 1.00 38. ,44 B C

ATOM 10021 CB ALA B 26 48. ,497 -51. 618- 104. ,851 1.00 37. ,53 B c

ATOM 10025 C ALA B 26 47. ,815 -53. 755- 103. ,757 1.00 37. ,97 B c

ATOM 10026 O ALA B 26 48. ,880 -54. 163- 103. ,276 1.00 35. ,67 B 0

ATOM 10028 N ARG B 27 46. ,614 -53. 961- 103. ,198 1.00 37. ,39 B N

ATOM 10029 CA ARG B 27 46. ,367 -54. 917- 102. ,114 1.00 33. ,76 B c

ATOM 10031 CB ARG B 27 45. ,733 -54. 211- 100.916 1.00 35. ,17 B c

ATOM 10034 CG ARG B 27 46. 688 -53. 261- 100. 242 1.00 35. ,76 B c

ATOM 10037 CD ARG B 27 46. 012 -52. 290 -99. 315 1.00 36. ,72 B c

ATOM 10040 NE ARG B 27 46. ,961 -51.252 -98. ,911 1.00 40.13 B N

ATOM 10042 CZ ARG B 27 47. ,322 -50. 208 -99. 662 1.00 42. ,42 B C

ATOM 10043 NHl ARG B 27 46. ,821 -50.035- 100. ,882 1.00 44. ,67 B N

ATOM 10046 NH2 ARG B 27 48. 196 -49. 327 -99. 185 1.00 42. ,63 B N

ATOM 10049 C ARG B 27 45. ,446 -56. 035- 102. 623 1.00 29. ,29 B C

ATOM 10050 0 ARG B 27 44. ,267 -56. 100- 102. 258 1.00 28. ,48 B 0

ATOM 10052 N PRO B 28 45. ,990 -56. 937- 103. 453 1.00 24. ,06 B N

ATOM 10053 CA PRO B 28 45. 188 -57. 936- 104. 184 1.00 27. ,75 B C

ATOM 10055 CB PRO B 28 46. ,191 -58. 540- 105. ,175 1.00 23. ,04 B C

ATOM 10058 CG PRO B 28 47. ,517 -58. 313- 104. ,590 1.00 20. ,43 B C

ATOM 10061 CD PRO B 28 47. ,433 -57. 082- 103. ,728 1.00 25. ,44 B c

ATOM 10064 C PRO B 28 44. 594 -59. 035- 103. 309 1.00 30. 78 B c

ATOM 10065 0 PRO B 28 43. 809 -59. 845- 103. ,793 1.00 33. 44 B 0

ATOM 10066 N TYR B 29 44. 974 -59. 054- 102. ,034 1.00 30. 08 B N

ATOM 10067 CA TYR B 29 44. 411 -59. 975- 101. ,050 1.00 27. 56 B c

ATOM 10069 CB TYR B 29 45. 421 -60. 210 -99. ,916 1.00 27. ,47 B c

ATOM 10072 CG TYR B 29 46. ,026 -58. 939 -99. ,364 1.00 27. ,98 B c

ATOM 10073 CDl TYR B 29 45. ,369 -58. 204 -98. ,389 1.00 22. ,35 B c

ATOM 10075 CEl TYR B 29 45. ,903 -57. 033 -97. ,898 1.00 26. ,78 B c

ATOM 10077 CZ TYR B 29 47. ,124 -56. 583 -98. ,359 1.00 26. ,15 B c

ATOM 10078 OH TYR B 29 47. ,643 -55. 414 -97. ,852 1.00 28. ,87 B 0

ATOM 10080 CE2 TYR B 29 47. ,807 -57. 285 -99. 333 1.00 26. ,84 B c

ATOM 10082 CD2 TYR B 29 47. 257 -58. 466 -99. ,829 1.00 27. ,81 B c

ATOM 10084 C TYR B 29 43. 089 -59. 463- ^■ 100. ,482 1.00 25. ,94 B c

ATOM 10085 0 TYR B 29 42. ,353 -60. ,209 -99. ,846 1.00 27. ,05 B 0

ATOM 10087 N MET B 30 42. ,782 -58. ,195- ^• 100. ,742 1.00 28. ,87 B N

ATOM 10088 CA MET B 30 41.681 -57. ,496- 100. ,084 1.00 26. ,23 B c

ATOM 10090 CB MET B 30 41. ,847 -55. ,983- ^■ 100. ,298 1.00 24. ,84 B c

ATOM 10093 CG MET B 30 40. ,893 -55. ,121 -99. ,475 1.00 26. ,92 B c

ATOM 10096 SD MET B 30 41. ,238 -55. ,209 -97. ,719 1.00 28. ,47 B s

ATOM 10097 CE MET B 30 39. ,598 -55. ,021 -97. ,022 1.00 16. ,99 B c

ATOM 10101 C MET B 30 40. ,300 -57. ,948- ^■ 100. ,573 1.00 29. ,35 B c

ATOM 10102 0 MET B 30 40. ,048 -58. ,006- ^• 101.783 1.00 31. ,19 B 0

ATOM 10104 N ALA B 31 39. ,404 -58. ,221 -99. ,619 1.00 29. ,61 B N

ATOM 10105 CA ALA B 31 38. ,071 -58. 752 -99. ,903 1.00 29. ,14 B c

ATOM 10107 CB ALA B 31 37. ,978 -60. 197 -99. ,454 1.00 26. ,12 B c

ATOM 10111 C ALA B 31 36. ,989 -57. 946 -99. ,208 1.00 32. ,79 B c

ATOM 10112 0 ALA B 31 37. ,211 -57. ,381 -98. ,126 1.00 38. ,34 B 0

ATOM 10114 N SER B 32 35. ,810 -57. 920 -99. ,828 1.00 33. ,73 B N

ATOM 10115 CA SER B 32 34. ,633 -57. ,255 -99. ,271 1.00 34. ,44 B c

ATOM 10117 CB SER B 32 34. ,071 -56. .241- ^• 100. .280 1.00 33. .21 B c

ATOM 10120 OG SER B 32 32. ,768 -55. ,805 -99. ,935 1.00 34. ,27 B 0

ATOM 10122 C SER B 32 33. ,581 -58. ,298 -98. ,917 1.00 35. .41 B c

ATOM 10123 0 SER B 32 33. ,181 -59. ,088 -99. ,767 1.00 38. ,54 B 0

ATOM 10125 N VAL B 33 33. ,134 -58. 293 -97. ,668 1.00 36. ,32 B N

ATOM 10126 CA VAL B 33 32. ,161 -59. ,270 -97. ,192 1.00 37. ,62 B c

ATOM 10128 CB VAL B 33 32. ,592 -59. ,855 -95. ,828 1.00 35. ,15 B c

ATOM 10130 CGI VAL B 33 31. ,480 -60. ,686 -95. ,184 1.00 32. ,81 B c

ATOM 10134 CG2 VAL B 33 33. ,851 -60. ,694 -96, .022 1.00 31, .95 B c

ATOM 10138 C VAL B 33 30. ,768 -58. ,624 -97. .178 1.00 40, .86 B c

ATOM 10139 0 VAL B 33 30. ,497 -57. ,690 -96. .414 1.00 39, .96 B 0 cyno fD_Fab

ATOM 10141 N GLN B 34 29. ,903 -59, ,132 -98. ,058 1.00 44. 03 B N

ATOM 10142 CA GLN B 34 28. ,619 -58, ,510 -98. ,377 1.00 44. 84 B C

ATOM 10144 CB GLN B 34 28. ,548 -58. ,195 -99. ,876 1.00 45. 16 B C

ATOM 10147 CG GLN B 34 29. ,813 -57. .603- 100. ,457 1.00 45. 06 B c

ATOM 10150 CD GLN B 34 29. ,623 -57. .108- 101. ,869 1.00 47. 25 B c

ATOM 10151 OEl GLN B 34 28. 623 -57. ,427- 102. ,520 1.00 50. 56 B 0

ATOM 10152 NE2 GLN B 34 30. 589 -56. ,328- 102. ,362 1.00 46. 11 B N

ATOM 10155 C GLN B 34 27. ,444 -59. ,414 -98. 032 1.00 45. 84 B c

ATOM 10156 O GLN B 34 27. 442 -60. ,599 -98. 372 1.00 44. 34 B 0

ATOM 10158 N VAL B 35 26. 456 -58. ,846 -97. 351 1.00 47. 01 B N

ATOM 10159 CA VAL B 35 25. 135 -59. ,448 -97. ,251 1.00 50. 74 B c

ATOM 10161 CB VAL B 35 24. 570 -59. ,411 -95. ,797 1.00 50. 19 B c

ATOM 10163 CGI VAL B 35 24. ,611 -58. ,001 -95. ,215 1.00 49. 71 B c

ATOM 10167 CG2 VAL B 35 23. ,154 -59. ,972 -95. ,754 1.00 48. 79 B c

ATOM 10171 C VAL B 35 24. ,233 -58. ,695 -98. ,244 1.00 54. 44 B c

ATOM 10172 O VAL B 35 24. 034 -57. ,479 -98. ,118 1.00 55. 41 B 0

ATOM 10174 N ASN B 36 23. 736 -59. ,416 -99. ,254 1.00 55. 06 B N

ATOM 10175 CA ASN B 36 22. ,794 -58. ,875- 100. ,247 1.00 55. 30 B c

ATOM 10177 CB ASN B 36 21. 499 -58. ,375 -99. 569 1.00 54. 25 B c

ATOM 10180 CG ASN B 36 20. 713 -59. ,493 -98. ,900 1.00 52. 40 B c

ATOM 10181 ODl ASN B 36 20. ,768 -60. .657 -99. ,318 1.00 50. 89 B 0

ATOM 10182 ND2 ASN B 36 19. ,957 -59. ,138 -97. ,868 1.00 46. 40 B N

ATOM 10185 C ASN B 36 23. ,393 -57. ,764- 101.118 1.00 58. 49 B c

ATOM 10186 O ASN B 36 22. ,795 -56. ,687- 101. ,273 1.00 60. 12 B 0

ATOM 10188 N GLY B 37 24. 578 -58. ,022- 101.673 1.00 57. 49 B N

ATOM 10189 CA GLY B 37 25. 234 -57. ,072- 102. ,578 1.00 55. 35 B c

ATOM 10192 C GLY B 37 25. 725 -55. ,766- 101. ,960 1.00 54. 30 B c

ATOM 10193 0 GLY B 37 26. 347 -54. ,962- 102. ,651 1.00 53. 82 B 0

ATOM 10195 N GLU B 38 25. 445 -55. ,552- 100. ,671 1.00 54. 27 B N

ATOM 10196 CA GLU B 38 25. ,910 -54. ,365 -99. ,932 1.00 54. 49 B c

ATOM 10198 CB GLU B 38 24. 753 -53. ,720 -99. ,156 1.00 57. 56 B c

ATOM 10201 CG GLU B 38 23. ,798 -52. ,911- 100. ,031 1.00 61. 34 B c

ATOM 10204 CD GLU B 38 22. ,734 -52. ,162 -99. 236 1.00 63. 69 B c

ATOM 10205 OEl GLU B 38 22. 447 -52. ,548 -98. ,079 1.00 66. 52 B 0

ATOM 10206 OE2 GLU B 38 22. 177 -51. ,184 -99. ,784 1.00 67. 77 B 0

ATOM 10207 C GLU B 38 27. 027 -54, .743 -98. ,954 1.00 51. 59 B c

ATOM 10208 O GLU B 38 26. 809 -55. ,545 -98. ,043 1.00 53. 44 B 0

ATOM 10210 N HIS B 39 28. ,215 -54. .164 -99. ,153 1.00 45. 66 B N

ATOM 10211 CA HIS B 39 29. ,347 -54. ,315 -98. ,229 1.00 42. 86 B c

ATOM 10213 CB HIS B 39 30. 449 -53. ,302 -98. ,584 1.00 39. 93 B c

ATOM 10216 CG HIS B 39 31. 598 -53. ,278 -97. ,620 1.00 38. 99 B c

ATOM 10217 NDl HIS B 39 31. ,508 -52. ,700 -96. ,370 1.00 36. 86 B N

ATOM 10219 CEl HIS B 39 32. 666 -52. ,823 -95. ,747 1.00 34. 48 B c

ATOM 10221 NE2 HIS B 39 33. 510 -53. ,448 -96. ,551 1.00 32. 04 B N

ATOM 10223 CD2 HIS B 39 32. 869 -53. ,738 -97. ,730 1.00 34. 29 B c

ATOM 10225 C HIS B 39 28. 929 -54. ,167 -96. ,748 1.00 40. 49 B c

ATOM 10226 O HIS B 39 28. ,206 -53. .238 -96. ,375 1.00 39. ,27 B 0

ATOM 10228 N LEU B 40 29. ,378 -55. .116 -95. ,929 1.00 38. ,74 B N

ATOM 10229 CA LEU B 40 29. ,152 -55. .110 -94. ,480 1.00 38. ,17 B c

ATOM 10231 CB LEU B 40 28. ,334 -56. .340 -94. ,074 1.00 36. ,78 B c

ATOM 10234 CG LEU B 40 28. ,118 -56. .623 -92. ,588 1.00 37. 93 B c

ATOM 10236 CDl LEU B 40 27. ,140 -55. .623 -91. ,933 1.00 41. ,67 B c

ATOM 10240 CD2 LEU B 40 27. ,651 -58. .054 -92. ,391 1.00 40. 25 B c

ATOM 10244 C LEU B 40 30. ,484 -55. ,104 -93. ,716 1.00 39. 13 B c

ATOM 10245 0 LEU B 40 30. ,627 -54, .381 -92. .713 1.00 37. ,41 B 0

ATOM 10247 N CYS B 41 31.432 -55, .920 -94. ,190 1.00 35. ,09 B N

ATOM 10248 CA CYS B 41 32. ,718 -56, .143 -93. ,529 1.00 35. ,01 B c

ATOM 10250 CB CYS B 41 32. ,672 -57, ,450 -92. ,735 1.00 39. ,73 B c

ATOM 10253 SG CYS B 41 31. ,959 -57, .264 -91. ,099 1.00 44. ,11 B S

ATOM 10255 C CYS B 41 33. ,846 -56, .245 -94. ,536 1.00 30. ,78 B c

ATOM 10256 0 CYS B 41 33. ,612 -56. .546 -95. ,697 1.00 33. ,34 B 0

ATOM 10258 N GLY B 42 35. 070 -56. .001 -94. ,077 1.00 29. 05 B N

ATOM 10259 CA GLY B 42 36. ,264 -56, .362 -94. ,829 1.00 27. ,22 B C

ATOM 10262 C GLY B 42 36. ,564 -57, .843 -94, ,619 1.00 25. 68 B c

ATOM 10263 0 GLY B 42 35. ,987 -58, .507 -93. .744 1.00 27. 95 B 0

ATOM 10265 N GLY B 43 37. ,458 -58, ,362 -95. .441 1.00 21.25 B N

ATOM 10266 CA GLY B 43 38. ,007 -59, .693 -95. ,258 1.00 25. 48 B c

ATOM 10269 C GLY B 43 39. ,326 -59, .717 -96. ,001 1.00 26. 84 B c cyno fD_Fab

ATOM 10270 O GLY B 43 39. ,730 -58. 702 -96. 582 1.00 22. ,17 B 0

ATOM 10272 N VAL B 44 39. ,974 -60. 876 -96. 001 1.00 28. ,47 B N

ATOM 10273 CA VAL B 44 41. ,301 -61. 033 -96. ,588 1.00 30. ,81 B C

ATOM 10275 CB VAL B 44 42. ,411 -60. 688 -95. ,554 1.00 34. ,36 B C

ATOM 10277 CGI VAL B 44 42. ,115 -61. 332 -94. ,198 1.00 36. ,04 B C

ATOM 10281 CG2 VAL B 44 43. ,778 -61.091 -96. ,079 1.00 28. ,87 B c

ATOM 10285 C VAL B 44 41. ,499 -62. 458 -97. ,100 1.00 31. 86 B c

ATOM 10286 O VAL B 44 41. ,210 -63. 418 -96. ,391 1.00 35. 40 B 0

ATOM 10288 N LEU B 45 41. ,998 -62. 574 -98. ,331 1.00 28. 42 B N

ATOM 10289 CA LEU B 45 42. ,223 -63. 858 -98. ,970 1.00 29. ,75 B c

ATOM 10291 CB LEU B 45 42. ,390 -63. 662- 100. ,495 1.00 26. ,37 B c

ATOM 10294 CG LEU B 45 42. ,378 -64. 822- 101. ,510 1.00 26. 08 B c

ATOM 10296 CDl LEU B 45 41. ,005 -65. 479- ^• 101. ,649 1.00 21. ,26 B c

ATOM 10300 CD2 LEU B 45 42. ,861 -64. 339- 102. ,881 1.00 24. ,35 B c

ATOM 10304 C LEU B 45 43. ,466 -64. 473 -98. ,330 1.00 33. ,62 B c

ATOM 10305 O LEU B 45 44. ,574 -63. 945 -98. ,472 1.00 34. ,99 B 0

ATOM 10307 N VAL B 46 43. ,273 -65. 576 -97. ,604 1.00 35. ,94 B N

ATOM 10308 CA VAL B 46 44. ,387 -66. 307 -96. ,972 1.00 32. ,69 B c

ATOM 10310 CB VAL B 46 44. ,124 -66. 576 -95. ,452 1.00 31.73 B c

ATOM 10312 CGI VAL B 46 44. 368 -65. 307 -94. ,651 1.00 27. ,65 B c

ATOM 10316 CG2 VAL B 46 42. ,708 -67. 123 -95. ,186 1.00 27. ,32 B c

ATOM 10320 C VAL B 46 44. ,786 -67. 608 -97. ,703 1.00 36. ,51 B c

ATOM 10321 O VAL B 46 45. ,856 -68. 156 -97. ,438 1.00 35. ,05 B 0

ATOM 10323 N ALA B 47 43. ,947 -68. 084 -98. ,627 1.00 36. ,31 B N

ATOM 10324 CA ALA B 47 44. ,247 -69. 280 -99. ,429 1.00 37. ,71 B c

ATOM 10326 CB ALA B 47 43. ,607 -70. 515 -98. ,804 1.00 33. ,79 B c

ATOM 10330 C ALA B 47 43. ,746 -69. 088- 100. ,862 1.00 40. 80 B c

ATOM 10331 O ALA B 47 43. ,374 -67. 980- 101. ,251 1.00 43. ,21 B 0

ATOM 10333 N GLU B 48 43. ,731 -70. 162- ^• 101.645 1.00 44. ,49 B N

ATOM 10334 CA GLU B 48 43. ,173 -70. 106- 102. ,999 1.00 44. ,53 B c

ATOM 10336 CB GLU B 48 43. ,706 -71. 270- ^• 103. ,849 1.00 46. ,73 B c

ATOM 10339 CG GLU B 48 43. ,980 -70. 917- 105. ,322 1.00 48. ,61 B c

ATOM 10342 CD GLU B 48 45. ,100 -71. 752- ^■ 105. ,957 1.00 50. ,86 B c

ATOM 10343 OEl GLU B 48 45. ,445 -72. 836- 105. ,426 1.00 54. ,50 B 0

ATOM 10344 OE2 GLU B 48 45. ,640 -71. 317- 107. ,002 1.00 52. ,98 B 0

ATOM 10345 C GLU B 48 41. ,629 -70. 085- •102. ,944 1.00 45. ,72 B c

ATOM 10346 O GLU B 48 40. ,987 -69. 596- 103. ,876 1.00 49. ,32 B 0

ATOM 10348 N GLN B 49 41. ,051 -70. 566- ^■ 101. ,836 1.00 42. ,23 B N

ATOM 10349 CA GLN B 49 39. ,596 -70. 722- 101. 684 1.00 40. ,07 B c

ATOM 10351 CB GLN B 49 39. ,249 -72. 213- ^■ 101. 799 1.00 42. ,74 B c

ATOM 10354 CG GLN B 49 37. ,753 -72. 541- 101. ,957 1.00 42. ,70 B c

ATOM 10357 CD GLN B 49 37. ,501 -73. 778- ^■ 102. ,822 1.00 42. ,73 B c

ATOM 10358 OEl GLN B 49 38. ,373 -74. 639- 102. ,976 1.00 41. ,86 B 0

ATOM 10359 NE2 GLN B 49 36. ,304 -73. 862- 103. ,393 1.00 43. ,64 B N

ATOM 10362 C GLN B 49 39. ,049 -70. 197- 100. ,355 1.00 38. ,48 B C

ATOM 10363 0 GLN B 49 37. ,893 -70. 465- 100. ,013 1.00 36. ,98 B 0

ATOM 10365 N TRP B 50 39. ,859 -69. 439 -99. ,614 1.00 39. ,16 B N

ATOM 10366 CA TRP B 50 39. ,511 -69. 054 -98. ,240 1.00 37. ,11 B C

ATOM 10368 CB TRP B 50 40. ,310 -69. 904 -97. ,255 1.00 37. ,00 B c

ATOM 10371 CG TRP B 50 39. ,878 -71. 330 -97. ,249 1.00 35. ,91 B c

ATOM 10372 CDl TRP B 50 40. ,410 -72. 359 -97. ,978 1.00 36. .02 B c

ATOM 10374 NEl TRP B 50 39. ,733 -73. 525 -97. ,709 1.00 35. ,72 B N

ATOM 10376 CE2 TRP B 50 38. ,737 -73. ,260 -96. .803 1.00 35. ,45 B c

ATOM 10377 CD2 TRP B 50 38. ,802 -71. ,886 -96. .490 1.00 33. ,75 B c

ATOM 10378 CE3 TRP B 50 37. ,881 -71. 353 -95. .581 1.00 34. ,88 B c

ATOM 10380 CZ3 TRP B 50 36. ,944 -72. 195 -95. .011 1.00 36. ,28 B c

ATOM 10382 CH2 TRP B 50 36, ,909 -73. 563 -95. ,334 1.00 35. ,59 B c

ATOM 10384 CZ2 TRP B 50 37. ,792 -74. 111 -96. ,228 1.00 35. ,62 B c

ATOM 10386 C TRP B 50 39. ,739 -67. 576 -97. ,948 1.00 35. ,98 B c

ATOM 10387 0 TRP B 50 40. ,752 -67. 002 -98. ,351 1.00 39. ,42 B 0

ATOM 10389 N VAL B 51 38. ,780 -66. 983 -97. ,239 1.00 32. ,08 B N

ATOM 10390 CA VAL B 51 38. ,814 -65. ,575 -96, .860 1.00 31. ,41 B c

ATOM 10392 CB VAL B 51 37. ,803 -64. ,752 -97, .697 1.00 30. .05 B c

ATOM 10394 CGI VAL B 51 37. ,700 -63. ,318 -97, .170 1.00 31. .04 B c

ATOM 10398 CG2 VAL B 51 38. ,206 -64. ,771 -99, .168 1.00 29. .64 B c

ATOM 10402 C VAL B 51 38. ,510 -65. ,401 -95, .360 1.00 30. ,22 B c

ATOM 10403 0 VAL B 51 37. ,450 -65. ,819 -94, .878 1.00 27. ,25 B 0

ATOM 10405 N LEU B 52 39. ,444 -64. ,760 -94. .648 1.00 28. ,01 B N cyno fD_Fab

ATOM 10406 CA LEU B 52 39. 348 -64. ,536 -93. ,202 1. 00 25. ,12 B C

ATOM 10408 CB LEU B 52 40. 755 -64. ,612 -92. 572 1. 00 26. 22 B C

ATOM 10411 CG LEU B 52 41. 004 -64. ,452 -91. 057 1. 00 26. ,17 B C

ATOM 10413 CDl LEU B 52 40. 288 -65. ,496 -90. ,213 1. 00 22. ,03 B C

ATOM 10417 CD2 LEU B 52 42. 514 -64. ,511 -90. ,808 1. 00 22. ,32 B C

ATOM 10421 C LEU B 52 38. 711 -63. 176 -92. ,946 1. 00 25. 46 B c

ATOM 10422 O LEU B 52 39. 041 -62. ,190 -93. ,608 1. 00 23. 81 B 0

ATOM 10424 N SER B 53 37. 795 -63. ,141 -91.983 1. 00 23. ,96 B N

ATOM 10425 CA SER B 53 37. 074 -61. ,948 -91. 630 1. 00 26. ,54 B c

ATOM 10427 CB SER B 53 35. 765 -61.884 -92. ,406 1. 00 29. 00 B c

ATOM 10430 OG SER B 53 35. 073 -60. ,676 -92. ,156 1. 00 30. ,28 B 0

ATOM 10432 C SER B 53 36. 808 -61. ,990 -90. ,128 1. 00 28. ,54 B c

ATOM 10433 O SER B 53 37. 444 -62. ,756 -89. ,409 1. 00 33. ,43 B 0

ATOM 10435 N ALA B 54 35. 878 -61.174 -89. ,659 1. 00 30. ,74 B N

ATOM 10436 CA ALA B 54 35. 540 -61. ,128 -88. ,237 1. 00 35. ,56 B c

ATOM 10438 CB ALA B 54 35. 390 -59. 697 -87. ,783 1. 00 30. 25 B c

ATOM 10442 C ALA B 54 34. 264 -61. ,928 -87. ,971 1. 00 40. 11 B c

ATOM 10443 O ALA B 54 33. 421 -62. ,083 -88. 855 1. 00 41. 26 B 0

ATOM 10445 N ALA B 55 34. 136 -62. ,438 -86. ,750 1. 00 43. 29 B N

ATOM 10446 CA ALA B 55 33. 062 -63. ,363 -86. ,395 1. 00 44. ,50 B c

ATOM 10448 CB ALA B 55 33. 397 -64. ,090 -85. ,103 1. 00 43. ,96 B c

ATOM 10452 C ALA B 55 31.712 -62. ,678 -86. ,272 1. 00 47. ,71 B c

ATOM 10453 O ALA B 55 30. 699 -63. ,259 -86. ,642 1. 00 50. 05 B 0

ATOM 10455 N HIS B 56 31. 697 -61.452 -85. ,760 1. 00 52. 45 B N

ATOM 10456 CA HIS B 56 30. 448 -60. ,717 -85. ,540 1. 00 54. ,47 B c

ATOM 10458 CB HIS B 56 30. 665 -59. ,580 -84. ,525 1. 00 60. ,79 B c

ATOM 10461 CG HIS B 56 29. 429 -59. ,172 -83. 773 1. 00 63. 96 B c

ATOM 10462 NDl HIS B 56 28. 947 -59. ,875 -82. 687 1. 00 68. 14 B N

ATOM 10464 CEl HIS B 56 27. 864 -59. ,277 -82. 220 1. 00 68. ,81 B c

ATOM 10466 NE2 HIS B 56 27. 633 -58. ,203 -82. ,954 1. 00 70. 12 B N

ATOM 10468 CD2 HIS B 56 28. 600 -58. ,111 -83. ,928 1. 00 68. 83 B C

ATOM 10470 C HIS B 56 29. 840 -60. ,167 -86. ,841 1. 00 55. ,04 B C

ATOM 10471 O HIS B 56 28. 730 -59. ,648 -86. ,816 1. 00 59. ,17 B 0

ATOM 10473 N CYS B 57 30. 554 -60. ,268 -87. ,963 1. 00 54. ,05 B N

ATOM 10474 CA CYS B 57 29. 960 -59. ,997 -89. ,280 1. 00 58. ,67 B C

ATOM 10476 CB CYS B 57 31. 013 -60. ,072 -90. ,395 1. 00 55. ,09 B c

ATOM 10479 SG CYS B 57 32. 453 -59. ,001 -90. ,167 1. 00 53. ,83 B S

ATOM 10481 C CYS B 57 28. 835 -60. ,995 -89. ,588 1. 00 63. ,07 B c

ATOM 10482 0 CYS B 57 27. 773 -60. ,615 -90. ,084 1. 00 63. ,91 B 0

ATOM 10484 N LEU B 58 29. 098 -62. .271 -89. ,302 1. 00 68. ,35 B N

ATOM 10485 CA LEU B 58 28. 111 -63. ,350 -89. ,411 1. 00 69. ,66 B c

ATOM 10487 CB LEU B 58 28. 703 -64. ,650 -88. ,845 1. 00 70. ,39 B c

ATOM 10490 CG LEU B 58 27. 943 -65. ,972 -89. 012 1. 00 69. ,34 B c

ATOM 10492 CDl LEU B 58 28. 465 -66. ,757 -90. ,211 1. 00 67. ,83 B c

ATOM 10496 CD2 LEU B 58 28. 063 -66. ,802 -87. 738 1. 00 69. ,82 B c

ATOM 10500 C LEU B 58 26. 821 -63. ,003 -88. ,662 1. 00 73. ,25 B c

ATOM 10501 0 LEU B 58 25. 732 -63. ,068 -89. ,234 1. 00 74. ,73 B 0

ATOM 10503 N GLU B 59 26. 955 -62. ,633 -87. ,388 1. 00 76. ,02 B N

ATOM 10504 CA GLU B 59 25. 810 -62. .239 -86. ,552 1. 00 78. ,84 B c

ATOM 10506 CB GLU B 59 26. 269 -61. .891 -85. ,126 1. 00 81. ,51 B c

ATOM 10509 CG GLU B 59 26. 472 -63. .104 -84. ,204 1. 00 83. ,71 B c

ATOM 10512 CD GLU B 59 25. 318 -63. ,320 -83. ,226 1. 00 84. ,97 B c

ATOM 10513 OEl GLU B 59 24. 787 -64. ,451 -83. ,162 1. 00 86. ,12 B 0

ATOM 10514 OE2 GLU B 59 24. 948 -62. ,360 -82. ,518 1. 00 85. ,36 B 0

ATOM 10515 C GLU B 59 25. 034 -61.058 -87. ,141 1. 00 81. ,28 B c

ATOM 10516 0 GLU B 59 23. 806 -61. ,107 -87. ,243 1. 00 82. ,12 B 0

ATOM 10518 N ASP B 60 25. 755 -60. ,006 -87. ,525 1. 00 82. ,96 B N

ATOM 10519 CA ASP B 60 25. 143 -58. ,795 -88. ,093 1. 00 82. ,97 B c

ATOM 10521 CB ASP B 60 26. 168 -57. ,648 -88. ,155 1. 00 83. ,36 B c

ATOM 10524 CG ASP B 60 26. 540 -57, ,106 -86. ,776 1. 00 83. ,92 B c

ATOM 10525 ODl ASP B 60 25. 890 -57. .480 -85. ,771 1. 00 84. ,33 B 0

ATOM 10526 OD2 ASP B 60 27. 489 -56. .294 -86. ,703 1. 00 82. ,79 B 0

ATOM 10527 C ASP B 60 24. 523 -59, .014 -89. ,483 1. 00 83. ,48 B c

ATOM 10528 0 ASP B 60 23. 625 -58. .268 -89. ,881 1. 00 83. ,47 B 0

ATOM 10530 N ALA B 61 24. 992 -60. .031 -90. ,210 1. 00 83. ,73 B N

ATOM 10531 CA ALA B 61 24. 459 -60. ,356 -91. ,546 1. 00 84. ,10 B c

ATOM 10533 CB ALA B 61 25. 361 -61. ,371 -92. ,249 1. 00 84. .18 B c

ATOM 10537 C ALA B 61 23. 014 -60. ,875 -91. ,524 1. 00 85. ,40 B c cyno fD_Fab

ATOM 10538 O ALA B 61 22. 353 -60. ,913 -92. 568 1.00 86. ,87 B 0

ATOM 10540 N ALA B 62 22. ,544 -61. ,287 -90. 344 1.00 83. ,95 B N

ATOM 10541 CA ALA B 62 21. ,169 -61. ,756 -90. 137 1.00 81. ,99 B C

ATOM 10543 CB ALA B 62 20. ,154 -60. ,643 -90. 461 1.00 81. ,06 B C

ATOM 10547 C ALA B 62 20. ,864 -63. 039 -90. 923 1.00 80. ,25 B C

ATOM 10548 O ALA B 62 20. 969 -64. ,137 -90. 377 1.00 78. 78 B 0

ATOM 10550 N ASP B 63 20. 501 -62. 901 -92. 196 1.00 79. 84 B N

ATOM 10551 CA ASP B 63 20. 071 -64. ,057 -93. 002 1.00 78. ,87 B C

ATOM 10553 CB ASP B 63 18. 614 -64. 414 -92. 645 1.00 80. ,66 B c

ATOM 10556 CG ASP B 63 17. ,714 -63. ,183 -92. 539 1.00 82. ,27 B c

ATOM 10557 ODl ASP B 63 17. ,276 -62. ,856 -91. 412 1.00 82. ,06 B 0

ATOM 10558 OD2 ASP B 63 17. 459 -62. ,536 -93. 579 1.00 82. ,85 B 0

ATOM 10559 C ASP B 63 20. 225 -63. ,917 -94. 534 1.00 77. 32 B c

ATOM 10560 O ASP B 63 19. 946 -64. ,872 -95. 265 1.00 77. ,78 B 0

ATOM 10562 N GLY B 64 20. 675 -62. ,757 -95. 018 1.00 73. ,64 B N

ATOM 10563 CA GLY B 64 20. 837 -62. 530 -96. 456 1.00 70. ,44 B c

ATOM 10566 C GLY B 64 21. 958 -63. 357 -97. 059 1.00 66. ,74 B c

ATOM 10567 O GLY B 64 22. 793 -63. ,909 -96. 338 1.00 63. ,69 B 0

ATOM 10569 N LYS B 65 21. ,976 -63. ,453 -98. 386 1.00 64. ,90 B N

ATOM 10570 CA LYS B 65 23. ,012 -64. ,225 -99. 069 1.00 63. ,63 B c

ATOM 10572 CB LYS B 65 22. 731 -64. 367- 100. 577 1.00 63. ,74 B c

ATOM 10575 CG LYS B 65 23. 587 -65. ,448- 101. 251 1.00 64. 33 B c

ATOM 10578 CD LYS B 65 23. 229 -65. 673- 102. 721 1.00 64. ,55 B c

ATOM 10581 CE LYS B 65 23. 361 -67. 153- 103. 101 1.00 64. ,73 B c

ATOM 10584 NZ LYS B 65 23. 335 -67. 416- 104. 584 1.00 63. ,36 B N

ATOM 10588 C LYS B 65 24. 366 -63. ,558 -98. 830 1.00 61. ,58 B c

ATOM 10589 0 LYS B 65 24. 615 -62. ,441 -99. 305 1.00 61.04 B 0

ATOM 10591 N VAL B 66 25. 220 -64. 237 -98. 064 1.00 57. ,01 B N

ATOM 10592 CA VAL B 66 26. 576 -63. 766 -97. 829 1.00 53. ,61 B c

ATOM 10594 CB VAL B 66 27. 210 -64. 410 -96. 582 1.00 52. ,73 B c

ATOM 10596 CGI VAL B 66 28. 705 -64. 126 -96. 538 1.00 52. ,64 B c

ATOM 10600 CG2 VAL B 66 26. 527 -63. 900 -95. 317 1.00 51. ,29 B c

ATOM 10604 C VAL B 66 27. 429 -64. 068 -99. 055 1.00 51. ,01 B c

ATOM 10605 0 VAL B 66 27. ,424 -65. ,188 -99. 573 1.00 51. 68 B 0

ATOM 10607 N GLN B 67 28. ,145 -63. 051 -99. 517 1.00 47. ,80 B N

ATOM 10608 CA GLN B 67 29. 021 -63. ,166- ^■ 100. 665 1.00 46. 92 B c

ATOM 10610 CB GLN B 67 28. 331 -62. 566- 101. 890 1.00 49. ,23 B c

ATOM 10613 CG GLN B 67 27. 111 -63. 356- 102. 372 1.00 48. 49 B c

ATOM 10616 CD GLN B 67 26. 428 -62. ,719- 103. 567 1.00 47. ,51 B c

ATOM 10617 OEl GLN B 67 26. 217 -61. ,501- 103. 607 1.00 45. ,66 B 0

ATOM 10618 NE2 GLN B 67 26. 070 -63. 545- 104. 552 1.00 46. ,56 B N

ATOM 10621 C GLN B 67 30. 329 -62. ,434- ^■ 100. 383 1.00 43. ,71 B c

ATOM 10622 0 GLN B 67 30. 394 -61. ,591 -99. 498 1.00 46. ,76 B 0

ATOM 10624 N VAL B 68 31. ,358 -62. ,756- ^■ 101. 152 1.00 41. ,06 B N

ATOM 10625 CA VAL B 68 32. 683 -62. ,174- ^■ 100. 988 1.00 40. ,46 B c

ATOM 10627 CB VAL B 68 33. 684 -63. ,251- ^■ 100. 507 1.00 39. ,79 B c

ATOM 10629 CGI VAL B 68 35. 116 -62. ,729- 100. 536 1.00 39. ,65 B c

ATOM 10633 CG2 VAL B 68 33. 298 -63. ,748 -99. 113 1.00 35. ,87 B c

ATOM 10637 C VAL B 68 33. 154 -61. ,581- ^■ 102. 321 1.00 37. ,53 B c

ATOM 10638 0 VAL B 68 33. ,271 -62. .293- 103. 314 1.00 32. ,48 B 0

ATOM 10640 N LEU B 69 33. ,416 -60. ,277- ^■ 102. ,342 1.00 38. ,13 B N

ATOM 10641 CA LEU B 69 33. 859 -59. .594- 103. ,568 1.00 38. ,71 B c

ATOM 10643 CB LEU B 69 33. 212 -58. ,198- ^■ 103. 671 1.00 39. ,39 B c

ATOM 10646 CG LEU B 69 33. 567 -57. ,339- ^■ 104. 891 1.00 38. ,23 B c

ATOM 10648 CD1 LEU B 69 33. ,055 -58. ,009- ^■ 106. 151 1.00 39. ,44 B c

ATOM 10652 CD2 LEU B 69 33. ,001 -55. ,915- ^■ 104. 742 1.00 40. ,33 B c

ATOM 10656 C LEU B 69 35. 384 -59. ,472- ^■ 103. 621 1.00 36. ,12 B c

ATOM 10657 0 LEU B 69 35. ,982 -58. ,654- ^■ 102. ,912 1.00 38. ,17 B 0

ATOM 10659 N LEU B 70 36. Oil -60. .292- ^■ 104. ,452 1.00 32. .95 B N

ATOM 10660 CA LEU B 70 37. 452 -60. ,198- ^■ 104. ,648 1.00 33. ,88 B c

ATOM 10662 CB LEU B 70 38. 074 -61. .584- ^■ 104. ,831 1.00 32. ,44 B C

ATOM 10665 CG LEU B 70 37. 897 -62. ,601- ^■ 103. ,697 1.00 30. ,43 B C

ATOM 10667 CDl LEU B 70 38. 680 -63. 864- ^■ 104. ,050 1.00 31. ,19 B c

ATOM 10671 CD2 LEU B 70 38. 339 -62. ,040- ^■ 102. 347 1.00 29. ,11 B c

ATOM 10675 C LEU B 70 37. 745 -59. ,315- ^■ 105. 856 1.00 35. ,58 B c

ATOM 10676 0 LEU B 70 36. ,823 -58. .921- ^■ 106. ,581 1.00 35. .91 B 0

ATOM 10678 N GLY B 71 39. ,029 -58. .999- -106. ,049 1.00 36. .24 B N

ATOM 10679 CA GLY B 71 39. ,505 -58. ,156- ^• 107. ,156 1.00 34, .22 B c cyno fD_Fab

ATOM 10682 C GLY B 71 38. 973 -56. ,726- 107. 263 1. 00 36. ,34 B C

ATOM 10683 O GLY B 71 39. ,074 -56. 123- 108. 334 1. 00 43. ,02 B 0

ATOM 10685 N ALA B 72 38. ,434 -56. 161- 106. 180 1. 00 32. ,78 B N

ATOM 10686 CA ALA B 72 37. ,756 -54. ,857- 106. 255 1. 00 31. ,64 B C

ATOM 10688 CB ALA B 72 36. ,463 -54. ,871- 105. 428 1. 00 29. ,09 B C

ATOM 10692 C ALA B 72 38. ,621 -53. ,684- 105. 821 1. 00 35. ,79 B c

ATOM 10693 O ALA B 72 39. ,355 -53. ,758- 104. 827 1. 00 44. ,04 B 0

ATOM 10695 N HIS B 73 38. ,528 -52. 589- 106. 566 1. 00 35. ,36 B N

ATOM 10696 CA HIS B 73 38. 888 -51. 283- 106. 027 1. 00 34. ,64 B c

ATOM 10698 CB HIS B 73 39. ,859 -50. 517- 106. 920 1. 00 33. ,76 B c

ATOM 10701 CG HIS B 73 40. 312 -49. 226- 106. 314 1. 00 34. ,97 B c

ATOM 10702 NDl HIS B 73 40. 630 -49. 110- ^■ 104. 978 1. 00 32. ,16 B N

ATOM 10704 CEl HIS B 73 40. ,975 -47. ,863- 104. 718 1. 00 34. ,95 B c

ATOM 10706 NE2 HIS B 73 40. ,895 -47. 165- ^• 105. 837 1. 00 36. ,36 B N

ATOM 10708 CD2 HIS B 73 40. ,487 -47. ,996- 106. 852 1. 00 34. 88 B C

ATOM 10710 C HIS B 73 37. ,618 -50. ,474- 105. 761 1. 00 33. ,41 B c

ATOM 10711 O HIS B 73 37. ,455 -49. 962- 104. 668 1. 00 29. 64 B 0

ATOM 10713 N SER B 74 36. 727 -50. 394- 106. 753 1. 00 34. 60 B N

ATOM 10714 CA SER B 74 35. 398 -49. 784- 106. 596 1. 00 35. 84 B c

ATOM 10716 CB SER B 74 34. 988 -49. 063- 107. 893 1. 00 38. ,62 B c

ATOM 10719 OG SER B 74 33. ,634 -48. ,618- 107. 839 1. 00 39. ,81 B 0

ATOM 10721 C SER B 74 34. ,303 -50. ,803- 106. 234 1. 00 34. ,63 B c

ATOM 10722 O SER B 74 34. ,206 -51. 867- 106. 837 1. 00 36. ,48 B 0

ATOM 10724 N LEU B 75 33. ,470 -50. ,453- 105. 257 1. 00 37. ,65 B N

ATOM 10725 CA LEU B 75 32. ,287 -51. ,251- 104. 909 1. 00 39. ,72 B c

ATOM 10727 CB LEU B 75 31. 670 -50. 784- 103. 571 1. 00 36. ,30 B c

ATOM 10730 CG LEU B 75 31.871 -51. 631- 102. 298 1. 00 37. 89 B c

ATOM 10732 CDl LEU B 75 33. 285 -52. 172- 102. 152 1. 00 37. ,78 B c

ATOM 10736 CD2 LEU B 75 31. 484 -50. 852- 101. 039 1. 00 37. ,56 B c

ATOM 10740 C LEU B 75 31. ,236 -51. ,205- 106. 039 1. 00 44. ,65 B c

ATOM 10741 0 LEU B 75 30. ,641 -52. 231- 106. 366 1. 00 47. ,52 B 0

ATOM 10743 N SER B 76 31. 033 -50. ,026- 106. 637 1. 00 45. ,22 B N

ATOM 10744 CA SER B 76 29. 980 -49. 816- 107. 650 1. 00 45. ,43 B c

ATOM 10746 CB SER B 76 29. 489 -48. ,366- 107. 622 1. 00 42. ,98 B c

ATOM 10749 OG SER B 76 28. 624 -48. 140- 106. 524 1. 00 44. ,06 B 0

ATOM 10751 C SER B 76 30. 415 -50. 140- 109. 078 1. 00 48. ,68 B c

ATOM 10752 0 SER B 76 29. 780 -50. 931- 109. 775 1. 00 47. ,16 B 0

ATOM 10754 N GLN B 77 31. 496 -49. ,509- 109. ,511 1. 00 51. ,43 B N

ATOM 10755 CA GLN B 77 31. ,885 -49. ,550- 110. 911 1. 00 52. ,24 B c

ATOM 10757 CB GLN B 77 32. ,910 -48. ,455- 111.203 1. 00 54. ,35 B c

ATOM 10760 CG GLN B 77 32. 380 -47. 047- 110. 949 1. 00 56. ,59 B c

ATOM 10763 CD GLN B 77 33. ,034 -46. ,007- 111.839 1. 00 59. ,71 B c

ATOM 10764 OEl GLN B 77 34. ,168 -46. 179- ^• 112. 301 1. 00 65. ,21 B 0

ATOM 10765 NE2 GLN B 77 32. 316 -44. ,919- ^• 112. 092 1. 00 62. ,48 B N

ATOM 10768 C GLN B 77 32. ,436 -50. ,916- ^• 111. 318 1. 00 52. ,78 B c

ATOM 10769 0 GLN B 77 33. 045 -51. ,609- ^• 110. 498 1. 00 50. ,73 B 0

ATOM 10771 N PRO B 78 32. ,208 -51. .314- ^• 112. ,587 1. 00 51.87 B N

ATOM 10772 CA PRO B 78 32. ,768 -52. ,561- ^• 113. ,084 1. 00 51. ,17 B C

ATOM 10774 CB PRO B 78 31. ,922 -52. ,850- ^• 114. ,323 1. 00 53. ,24 B C

ATOM 10777 CG PRO B 78 31. ,574 -51. ,498- ^• 114. ,843 1. 00 53. ,16 B C

ATOM 10780 CD PRO B 78 31. ,410 -50. 625- 113. ,619 1. 00 52. ,36 B c

ATOM 10783 C PRO B 78 34. ,237 -52. ,400- ^• 113. ,469 1. 00 51. ,68 B c

ATOM 10784 0 PRO B 78 34. ,638 -51. 339- ^• 113. ,954 1. 00 51. ,10 B 0

ATOM 10785 N GLU B 79 35. 022 -53. ,450- 113. 230 1. 00 51. ,32 B N

ATOM 10786 CA GLU B 79 36. ,442 -53. ,491- ^■ 113. 587 1. 00 50. .10 B c

ATOM 10788 CB GLU B 79 37. ,343 -53. .141- ^• 112. ,393 1. 00 50. .71 B c

ATOM 10791 CG GLU B 79 36. ,867 -51. ,977- ^• 111. ,522 1. 00 51. ,07 B c

ATOM 10794 CD GLU B 79 37. ,676 -51. ,847- ^■ 110. 246 1. 00 50. .71 B c

ATOM 10795 OEl GLU B 79 37. ,238 -52. ,404- ^• 109. 219 1. 00 47. .87 B 0

ATOM 10796 OE2 GLU B 79 38. ,749 -51. ,204- ^■ 110. 277 1. 00 52. ,10 B 0

ATOM 10797 C GLU B 79 36. ,766 -54. .908- ^■ 114. 050 1. 00 50. ,42 B c

ATOM 10798 0 GLU B 79 36. ,056 -55. .854- ^• 113. ,686 1. 00 49. ,26 B 0

ATOM 10800 N PRO B 80 37. ,854 -55. ,071- •114. ,827 1. 00 50. ,66 B N

ATOM 10801 CA PRO B 80 38. ,137 -56. .411- ^• 115. ,340 1. 00 50, .02 B c

ATOM 10803 CB PRO B 80 39. ,454 -56. .235- 116. ,123 1. 00 49, .95 B c

ATOM 10806 CG PRO B 80 39. ,571 -54. ,771- 116. ,392 1. 00 50, .08 B c

ATOM 10809 CD PRO B 80 38. 878 -54. ,091- ^• 115. ,241 1. 00 51. .02 B c

ATOM 10812 C PRO B 80 38. 312 -57. ,415- -114. ,203 1. 00 50. .32 B c cyno fD_Fab

ATOM 10813 O PRO B 80 37. ,763 -58. ,516- ^■ 114. 264 1. 00 51. ,01 B 0

ATOM 10814 N SER B 81 39. ,036 -57. ,008- ^• 113. 159 1. 00 49. 68 B N

ATOM 10815 CA SER B 81 39. ,451 -57. ,918- ^• 112. 090 1. 00 46.44 B C

ATOM 10817 CB SER B 81 40. ,692 -57. ,365- 111.388 1. 00 47. 39 B C

ATOM 10820 OG SER B 81 41. 824 -57. 496- ^■ 112. 238 1. 00 49. 26 B 0

ATOM 10822 C SER B 81 38. ,359 -58. ,244- 111.073 1. 00 42. ,87 B C

ATOM 10823 O SER B 81 38. ,431 -59. ,271- 110. 401 1. 00 43. ,41 B 0

ATOM 10825 N LYS B 82 37. 348 -57. 394- ^■ 110. 963 1. 00 41. ,44 B N

ATOM 10826 CA LYS B 82 36. 255 -57. 648- 110. 023 1. 00 43. 60 B C

ATOM 10828 CB LYS B 82 35. 181 -56. 548- ^■ 110. 102 1. 00 44. 07 B c

ATOM 10831 CG LYS B 82 35. 574 -55. 204- 109. 497 1. 00 43. 51 B c

ATOM 10834 CD LYS B 82 34. 430 -54. 194- ^■ 109. 573 1. 00 43. 53 B c

ATOM 10837 CE LYS B 82 33. 345 -54. 458- 108. 535 1. 00 43. 93 B c

ATOM 10840 NZ LYS B 82 32. ,353 -53. 333- ^• 108. 456 1. 00 43. ,72 B N

ATOM 10844 C LYS B 82 35. ,600 -59. 000- 110. 295 1. 00 43. ,44 B c

ATOM 10845 O LYS B 82 35. ,435 -59. 392- ^• 111. 448 1. 00 46. 25 B 0

ATOM 10847 N ARG B 83 35. ,254 -59. ,710- 109. 225 1. 00 43. 81 B N

ATOM 10848 CA ARG B 83 34. 359 -60. ,859- 109. 308 1. 00 44. 23 B c

ATOM 10850 CB ARG B 83 35. 082 -62. ,101- 109. 814 1. 00 46. 54 B c

ATOM 10853 CG ARG B 83 34. 240 -63. ,352- 109. 627 1. 00 47. 37 B c

ATOM 10856 CD ARG B 83 34. 614 -64. 466- 110. 564 1. 00 49. 39 B c

ATOM 10859 NE ARG B 83 33. ,843 -65. ,661- ^• 110. 233 1. 00 50. 24 B N

ATOM 10861 CZ ARG B 83 33. ,730 -66. ,730- 111.011 1. 00 53. ,60 B c

ATOM 10862 NHl ARG B 83 34. 336 -66. ,776- •112. 196 1. 00 53. ,54 B N

ATOM 10865 NH2 ARG B 83 32. ,995 -67. ,761- 110. 597 1. 00 54. ,70 B N

ATOM 10868 C ARG B 83 33. 718 -61. ,189- ^• 107. 964 1. 00 44. 24 B C

ATOM 10869 O ARG B 83 34. 420 -61. ,415- 106. 976 1. 00 46. 63 B 0

ATOM 10871 N LEU B 84 32. 387 -61. ,244- ^• 107. 951 1. 00 42. 37 B N

ATOM 10872 CA LEU B 84 31. 615 -61. 652- 106. 782 1. 00 40. 91 B C

ATOM 10874 CB LEU B 84 30. ,180 -61.121- ^• 106. 913 1. 00 41. ,66 B C

ATOM 10877 CG LEU B 84 29. 233 -61. ,185- ^• 105. 708 1. 00 42. ,19 B c

ATOM 10879 CDl LEU B 84 29. ,977 -60. ,904- ^• 104. 425 1. 00 41. , 22 B c

ATOM 10883 CD2 LEU B 84 28. ,075 -60. ,198- 105. 877 1. 00 41. 26 B c

ATOM 10887 C LEU B 84 31. 630 -63. ,185- 106. 657 1. 00 41. 57 B c

ATOM 10888 0 LEU B 84 31. 649 -63. ,891- ^■ 107. 675 1. 00 39. 59 B 0

ATOM 10890 N TYR B 85 31.658 -63. ,684- 105. 415 1. 00 41. 98 B N

ATOM 10891 CA TYR B 85 31. 714 -65. ,130- ^■ 105. 114 1. 00 41.55 B c

ATOM 10893 CB TYR B 85 33. ,092 -65. .521- ^• 104. ,579 1. 00 37. ,99 B c

ATOM 10896 CG TYR B 85 34. ,205 -65. ,556- ^■ 105. ,598 1. 00 37. ,60 B c

ATOM 10897 CDl TYR B 85 34. 540 -66. ,734- ^• 106. ,257 1. 00 36. ,48 B c

ATOM 10899 CEl TYR B 85 35. 586 -66.768- ^• 107. ,179 1. 00 37. ,61 B c

ATOM 10901 CZ TYR B 85 36. ,311 -65. 611- ^• 107. 437 1. 00 37. ,65 B c

ATOM 10902 OH TYR B 85 37. 349 -65. 607- ^■ 108. 345 1. 00 38. ,79 B 0

ATOM 10904 CE2 TYR B 85 36. 001 -64. ,444- 106. 786 1. 00 37. 52 B c

ATOM 10906 CD2 TYR B 85 34. 957 -64. ,422- 105. 868 1. 00 38. 01 B c

ATOM 10908 C TYR B 85 30. ,651 -65. .506- ^■ 104. ,074 1. 00 42. 35 B c

ATOM 10909 0 TYR B 85 29. ,925 -64. ,649- 103. ,589 1. 00 40. ,36 B 0

ATOM 10911 N ASP B 86 30. 568 -66. .788- ^• 103. ,726 1. 00 45. ,39 B N

ATOM 10912 CA ASP B 86 29. ,494 -67. .279- 102. ,861 1. 00 48. ,04 B c

ATOM 10914 CB ASP B 86 28. ,464 -68. .043- ^■ 103. ,715 1. 00 51. 98 B c

ATOM 10917 CG ASP B 86 27. ,019 -67. .680- 103. ,375 1. 00 55. 44 B c

ATOM 10918 ODl ASP B 86 26. ,702 -67. ,485- 102. ,172 1. 00 55. 49 B 0

ATOM 10919 OD2 ASP B 86 26. ,204 -67. .599- -104. ,326 1. 00 56. ,18 B 0

ATOM 10920 C ASP B 86 30. ,025 -68. ,173- ^■ 101. ,728 1. 00 47. .18 B c

ATOM 10921 0 ASP B 86 31. ,009 -68. ,899- ^■ 101. ,893 1. 00 44. ,10 B 0

ATOM 10923 N VAL B 87 29. ,344 -68. ,123- ^■ 100. ,588 1. 00 51. ,42 B N

ATOM 10924 CA VAL B 87 29. ,763 -68. ,846 -99. ,388 1. 00 53. 62 B c

ATOM 10926 CB VAL B 87 29. ,495 -68. ,011 -98. ,088 1. 00 52. ,27 B c

ATOM 10928 CGI VAL B 87 28. ,004 -67. ,973 -97. ,729 1. 00 50. ,27 B c

ATOM 10932 CG2 VAL B 87 30. 293 -68. ,572 -96. ,925 1. 00 53. 70 B c

ATOM 10936 C VAL B 87 29. ,060 -70. ,204 -99. ,282 1. 00 56. ,34 B c

ATOM 10937 0 VAL B 87 27. ,860 -70. .266 -98. ,998 1. 00 59. ,22 B 0

ATOM 10939 N LEU B 88 29. ,802 -71. .285 -99. ,513 1. 00 56. ,61 B N

ATOM 10940 CA LEU B 88 29. ,291 -72. ,628 -99. ,208 1. 00 56. ,36 B C

ATOM 10942 CB LEU B 88 30. ,135 -73. ,743 -99. ,828 1. 00 55. ,73 B C

ATOM 10945 CG LEU B 88 30. ,927 -73. ,474- -101. ,101 1. 00 57. ,16 B C

ATOM 10947 CDl LEU B 88 32. 233 -72. ,804- ^■ 100. ,738 1. 00 57. ,21 B c

ATOM 10951 CD2 LEU B 88 31. ,194 -74. ,772- -101.852 1. 00 56. ,77 B c fD_Fab

ATOM 10955 C LEU B 88 29. .2*9 -72. ,816 -97, .696 1.00 58. 15 B C

ATOM 10956 O LEU B 88 28. ,382 -73. ,460 -97. ,148 1.00 59. 20 B 0

ATOM 10958 N ARG B 89 30. 279 -72. 240 -97. ,031 1.00 58. 02 B N

ATOM 10959 CA ARG B 89 30. ,506 -72. 476 -95. ,615 1.00 56. 49 B C

ATOM 10961 CB ARG B 89 31. ,493 -73. 637 -95. ,462 1.00 56. 31 B C

ATOM 10964 CG ARG B 89 31.111 -74. 655 -94. ,403 1.00 58. 01 B c

ATOM 10967 CD ARG B 89 32. ,308 -75. ,519 -94. ,014 1.00 58. 69 B c

ATOM 10970 NE ARG B 89 32. ,954 -76. ,161 -95. ,165 1.00 59. 80 B N

ATOM 10972 CZ ARG B 89 34. 171 -76. ,716 -95. ,142 1.00 59. 60 B c

ATOM 10973 NHl ARG B 89 34. 903 -76. ,713 -94. ,029 1.00 59. 72 B N

ATOM 10976 NH2 ARG B 89 34. ,667 -77. ,275 -96. ,242 1.00 59. 64 B N

ATOM 10979 C ARG B 89 31.059 -71. ,213 -94. ,936 1.00 55. 64 B c

ATOM 10980 O ARG B 89 32. ,066 -70. 659 -95. ,379 1.00 55. 70 B 0

ATOM 10982 N ALA B 90 30. ,383 -70. ,761 -93. ,879 1.00 53. 33 B N

ATOM 10983 CA ALA B 90 30. ,890 -69. ,707 -93. ,007 1.00 53. 35 B C

ATOM 10985 CB ALA B 90 29. ,846 -68. ,626 -92. ,805 1.00 51. 34 B c

ATOM 10989 C ALA B 90 31. ,248 -70. ,361 -91. ,676 1.00 54. 21 B c

ATOM 10990 O ALA B 90 30. 362 -70. ,827 -90. ,960 1.00 55. 99 B 0

ATOM 10992 N VAL B 91 32. 544 -70. ,405 -91. 362 1.00 53. 95 B N

ATOM 10993 CA VAL B 91 33. 053 -71. ,093 -90.168 1.00 52. 71 B c

ATOM 10995 CB VAL B 91 34. 194 -72. ,075 -90. 532 1.00 51. 83 B c

ATOM 10997 CGI VAL B 91 34. ,645 -72. ,862 -89. ,299 1.00 49. 35 B c

ATOM 11001 CG2 VAL B 91 33. ,757 -73. ,014 -91. ,651 1.00 52. 30 B c

ATOM 11005 C VAL B 91 33. ,585 -70. ,090 -89. ,139 1.00 52. 51 B c

ATOM 11006 O VAL B 91 34. ,754 -69. ,693 -89. ,209 1.00 51. 51 B 0

ATOM 11008 N PRO B 92 32. ,736 -69. ,681 -88. ,175 1.00 53. 51 B N

ATOM 11009 CA PRO B 92 33. 224 -68. ,806 -87. ,114 1.00 51. 85 B c

ATOM 11011 CB PRO B 92 31. 939 -68. ,294 -86. ,452 1.00 53. 50 B c

ATOM 11014 CG PRO B 92 30. 949 -69. ,371 -86. ,674 1.00 54. 78 B c

ATOM 11017 CD PRO B 92 31. 309 -70. ,016 -87. ,997 1.00 54. 99 B c

ATOM 11020 C PRO B 92 34. 040 -69. ,619 -86. ,131 1.00 53. 38 B c

ATOM 11021 0 PRO B 92 33. 904 -70. ,847 -86. ,091 1.00 55. 30 B 0

ATOM 11022 N HIS B 93 34. 887 -68. ,954 -85. ,352 1.00 49. 46 B N

ATOM 11023 CA HIS B 93 35. ,687 -69. ,656 -84. ,364 1.00 50. 17 B C

ATOM 11025 CB HIS B 93 36. 722 -68. ,729 -83. ,736 1.00 44. 28 B C

ATOM 11028 CG HIS B 93 37. ,747 -69. ,441 -82. ,913 1.00 43. 03 B c

ATOM 11029 NDl HIS B 93 37. 558 -69. ,741 -81.580 1.00 40. 49 B N

ATOM 11031 CEl HIS B 93 38. 625 -70. ,367 -81. ,119 1.00 39. 25 B c

ATOM 11033 NE2 HIS B 93 39. 499 -70. ,477 -82. ,100 1.00 40. 46 B N

ATOM 11035 CD2 HIS B 93 38. 974 -69. ,910 -83. ,234 1.00 39. 10 B C

ATOM 11037 C HIS B 93 34. 739 -70. 223 -83. ,307 1.00 51. 86 B C

ATOM 11038 0 HIS B 93 33. 852 -69. ,508 -82. ,838 1.00 49. 69 B 0

ATOM 11040 N PRO B 94 34. 906 -71. ,518 -82. ,948 1.00 56. 85 B N

ATOM 11041 CA PRO B 94 33. 962 -72. ,200 -82. ,044 1.00 57. 28 B c

ATOM 11043 CB PRO B 94 34. 512 -73. ,632 -81. ,966 1.00 58. 38 B c

ATOM 11046 CG PRO B 94 35. 934 -73. .540 -82. .418 1.00 59. 16 B c

ATOM 11049 CD PRO B 94 35. ,977 -72. ,426 -83. .407 1.00 57. 31 B c

ATOM 11052 C PRO B 94 33. ,813 -71. ,613 -80. .639 1.00 59. 70 B c

ATOM 11053 0 PRO B 94 32. ,944 -72. ,058 -79. ,888 1.00 61. 05 B 0

ATOM 11054 N ASP B 95 34. ,644 -70. ,633 -80. .291 1.00 62. 36 B N

ATOM 11055 CA ASP B 95 34. ,550 -69. ,943 -79. ,006 1.00 62. 17 B c

ATOM 11057 CB ASP B 95 35. ,897 -70. ,022 -78. ,291 1.00 62. 64 B c

ATOM 11060 CG ASP B 95 36. ,443 -71. ,448 -78. ,239 1.00 64. 10 B c

ATOM 11061 ODl ASP B 95 35. 639 -72. 379 -78. ,025 1.00 64. 82 B 0

ATOM 11062 0D2 ASP B 95 37. 667 -71. ,642 -78. ,414 1.00 62. 75 B 0

ATOM 11063 C ASP B 95 34. 091 -68. ,488 -79. ,160 1.00 62. 12 B c

ATOM 11064 0 ASP B 95 34. 092 -67. ,733 -78. ,190 1.00 62. 21 B 0

ATOM 11066 N SER B 96 33. ,686 -68. ,108 -80, .373 1.00 64. 12 B N

ATOM 11067 CA SER B 96 33. ,072 -66. ,801 -80, .622 1.00 67. 86 B c

ATOM 11069 CB SER B 96 32. ,769 -66. ,610 -82, .114 1.00 67. 27 B c

ATOM 11072 OG SER B 96 33. ,944 -66. ,581 -82, .896 1.00 69. 32 B 0

ATOM 11074 C SER B 96 31. ,756 -66. ,690 -79, .868 1.00 71. 20 B c

ATOM 11075 0 SER B 96 30. ,903 -67. ,566 -79, .995 1.00 73. 91 B 0

ATOM 11077 N ARG B 97 31. ,585 -65. ,618 -79. .100 1.00 72. 33 B N

ATOM 11078 CA ARG B 97 30. ,307 -65. ,338 -78. .443 1.00 74. 80 B c

ATOM 11080 CB ARG B 97 30. ,452 -65. ,464 -76.920 1.00 77. 11 B c

ATOM 11083 CG ARG B 97 30. ,883 -66. ,859 -76. .437 1.00 78. 58 B c

ATOM 11086 CD ARG B 97 29. ,812 -67. ,931 -76. ,689 1.00 78. 97 B c cyno fD_Fab

ATOM 11089 NE ARG B 97 30. 189 -69. ,250 -76. 160 1. 00 78. ,73 B N

ATOM 11091 CZ ARG B 97 30. ,803 -70. ,224 -76. 841 1. 00 78. ,40 B C

ATOM 11092 NHl ARG B 97 31. ,143 -70. ,073 -78. 115 1. 00 78. ,11 B N

ATOM 11095 NH2 ARG B 97 31. 081 -71. ,374 -76. 238 1. 00 78. ,88 B N

ATOM 11098 C ARG B 97 29. 808 -63. ,942 -78. 848 1. 00 77. ,20 B C

ATOM 11099 O ARG B 97 30. 611 -63. ,069 -79. 192 1. 00 78. ,19 B 0

ATOM 11101 N PRO B 98 28. 478 -63. ,725 -78. 820 1. 00 79. ,22 B N

ATOM 11102 CA PRO B 98 27. 922 -62. 438 -79. 259 1. 00 77. 99 B C

ATOM 11104 CB PRO B 98 26. 412 -62. ,708 -79. 303 1. 00 79. ,41 B c

ATOM 11107 CG PRO B 98 26. ,194 -63. ,786 -78. 299 1. 00 80. ,09 B c

ATOM 11110 CD PRO B 98 27. ,421 -64. ,654 -78. 373 1. 00 80. ,51 B c

ATOM 11113 C PRO B 98 28. 224 -61. ,273 -78. 314 1. 00 77. ,83 B c

ATOM 11114 0 PRO B 98 28. 195 -60. ,115 -78. 738 1. 00 81. ,07 B 0

ATOM 11115 N ASP B 99 28. 520 -61. ,584 -77. 055 1. 00 75. ,45 B N

ATOM 11116 CA ASP B 99 28. 696 -60. ,567 -76. 018 1. 00 74. ,68 B c

ATOM 11118 CB ASP B 99 27. 808 -60. ,903 -74. 806 1. 00 75. ,42 B c

ATOM 11121 CG ASP B 99 28. 062 -62. ,305 -74. 242 1. 00 75. ,50 B c

ATOM 11122 ODl ASP B 99 28. 493 -63. ,208 -74. 998 1. 00 75. ,59 B 0

ATOM 11123 OD2 ASP B 99 27. 816 -62. ,501 -73. 034 1. 00 74. ,97 B 0

ATOM 11124 C ASP B 99 30. 166 -60. ,370 -75. 590 1. 00 74. ,55 B c

ATOM 11125 0 ASP B 99 30. 433 -59. ,783 -74. 529 1. 00 73. ,12 B 0

ATOM 11127 N THR B 100 31. 102 -60. ,857 -76. 416 1. 00 71.97 B N

ATOM 11128 CA THR B 100 32. 549 -60. ,683 -76. 191 1. 00 68. ,31 B c

ATOM 11130 CB THR B 100 33. 209 -61. ,940 -75. 531 1. 00 68. ,10 B c

ATOM 11132 OGl THR B 100 33. 318 -63. ,007 -76. 485 1. 00 67. ,69 B 0

ATOM 11134 CG2 THR B 100 32. 413 -62. ,419 -74. 319 1. 00 67. ,27 B c

ATOM 11138 C THR B 100 33. 269 -60. ,388 -77. 512 1. 00 66. ,00 B c

ATOM 11139 0 THR B 100 32. 760 -60. ,730 -78. 586 1. 00 65. ,38 B 0

ATOM 11141 N ILE B 101 34. 446 -59. ,760 -77. 423 1. 00 62. ,94 B N

ATOM 11142 CA ILE B 101 35. 312 -59. ,518 -78. 606 1. 00 60. ,61 B c

ATOM 11144 CB ILE B 101 36. 047 -58. ,113 -78. 585 1. 00 60. 32 B c

ATOM 11146 CGI ILE B 101 36. 571 -57. ,713 -77. 191 1. 00 60. ,38 B c

ATOM 11149 CDl ILE B 101 37. 460 -58. ,737 -76. 504 1. 00 61.59 B c

ATOM 11153 CG2 ILE B 101 35. 111 -57. ,023 -79. 090 1. 00 62. ,64 B c

ATOM 11157 C ILE B 101 36. 344 -60. ,637 -78. 832 1. 00 56. ,19 B c

ATOM 11158 0 ILE B 101 37. 126 -60. ,580 -79. 792 1. 00 52. ,05 B 0

ATOM 11160 N ASP B 102 36. 323 -61. ,650 -77. 961 1. 00 54. ,84 B N

ATOM 11161 CA ASP B 102 37. 302 -62. 744 -77. 994 1. 00 53. ,53 B c

ATOM 11163 CB ASP B 102 37. 281 -63. 526 -76. 678 1. 00 53. ,90 B c

ATOM 11166 CG ASP B 102 37. 603 -62. 660 -75. 467 1. 00 54. ,72 B c

ATOM 11167 ODl ASP B 102 38. 778 -62. ,275 -75. 287 1. 00 53. ,14 B 0

ATOM 11168 OD2 ASP B 102 36. 676 -62. .381 -74. 680 1. 00 57. ,45 B 0

ATOM 11169 C ASP B 102 37. 032 -63. ,707 -79. 140 1. 00 52. ,43 B c

ATOM 11170 0 ASP B 102 35. 880 -63. ,999 -79. 452 1. 00 53. ,84 B 0

ATOM 11172 N HIS B 103 38. 105 -64. ,210 -79. 750 1. 00 52. ,18 B N

ATOM 11173 CA HIS B 103 38. 029 -65. ,200 -80. 840 1. 00 50. ,40 B c

ATOM 11175 CB HIS B 103 37. 534 -66. ,562 -80. 306 1. 00 46. ,91 B c

ATOM 11178 CG HIS B 103 37. 967 -66. ,840 -78. 901 1. 00 43. ,50 B c

ATOM 11179 NDl HIS B 103 39. 270 -67. ,144 -78. 569 1. 00 39. ,79 B N

ATOM 11181 CEl HIS B 103 39. 365 -67. ,292 -77. 260 1. 00 40. .28 B c

ATOM 11183 NE2 HIS B 103 38. 173 -67. ,086 -76. ,729 1. 00 42. .73 B N

ATOM 11185 CD2 HIS B 103 37. 284 -66. ,786 -77. 732 1. 00 43. .67 B c

ATOM 11187 C HIS B 103 37. 169 -64. ,695 -82. 002 1. 00 50. ,92 B c

ATOM 11188 0 HIS B 103 36. 416 -65. ,457 -82. 606 1. 00 52. ,58 B 0

ATOM 11190 N ASP B 104 37. 318 -63. ,408 -82. 320 1. 00 48. ,05 B N

ATOM 11191 CA ASP B 104 36. 531 -62. ,752 -83. 362 1. 00 45. ,62 B c

ATOM 11193 CB ASP B 104 36. 468 -61. ,237 -83. 082 1. 00 49. ,77 B c

ATOM 11196 CG ASP B 104 35. 301 -60. .539 -83. ,798 1. 00 51, .56 B c

ATOM 11197 ODl ASP B 104 34. 758 -61. .095 -84. ,781 1. 00 49, .90 B 0

ATOM 11198 002 ASP B 104 34. 932 -59. .422 -83. ,364 1. 00 51. .77 B 0

ATOM 11199 C ASP B 104 37. 096 -63. ,039 -84. 763 1. 00 42. .55 B c

ATOM 11200 0 ASP B 104 37. 383 -62. ,124 -85. ,544 1. 00 44. ,53 B 0

ATOM 11202 N LEU B 105 37. 243 -64. ,318 -85. ,078 1. 00 38. .63 B N

ATOM 11203 CA LEU B 105 37. 646 -64. ,736 -86. ,408 1. 00 39, ,07 B C

ATOM 11205 CB LEU B 105 38. 946 -65. ,551 -86. ,365 1. 00 36. ,49 B C

ATOM 11208 CG LEU B 105 40. ,246 -64, .834 -85. ,975 1. 00 35, .30 B C

ATOM 11210 CDl LEU B 105 41. ,428 -65. .680 -86. ,418 1. 00 30, .02 B C

ATOM 11214 CD2 LEU B 105 40. 350 -63. ,419 -86. ,564 1. 00 27, .58 B C cyno fD_Fab

ATOM 11218 C LEU B 105 36. 529 -65. 531 -87. 084 1.00 37. ,85 B C

ATOM 11219 O LEU B 105 35. 570 -65. 987 -86. 451 1.00 36. ,57 B 0

ATOM 11221 N LEU B 106 36. 672 -65. 669 -88. 392 1.00 38. ,28 B N

ATOM 11222 CA LEU B 106 35. 652 -66. 253 -89. 236 1.00 37. ,87 B C

ATOM 11224 CB LEU B 106 34. 492 -65. 269 -89. 425 1.00 37. ,41 B C

ATOM 11227 CG LEU B 106 33. 396 -65. 570 -90. 451 1.00 38. ,93 B C

ATOM 11229 CDl LEU B 106 32. 659 -66. 829 -90. 070 1.00 40. ,78 B C

ATOM 11233 CD2 LEU B 106 32. 418 -64. 421 -90. 557 1.00 38. ,72 B c

ATOM 11237 C LEU B 106 36. 332 -66. 526 -90. 549 1.00 35. ,77 B c

ATOM 11238 O LEU B 106 36. 895 -65. 617 -91. 139 1.00 36. ,74 B 0

ATOM 11240 N LEU B 107 36. 332 -67. 788 -90. 967 1.00 37. ,47 B N

ATOM 11241 CA LEU B 107 36. 800 -68. 161 -92. 291 1.00 37. ,61 B c

ATOM 11243 CB LEU B 107 37. 690 -69. 408 -92. 245 1.00 33. ,00 B c

ATOM 11246 CG LEU B 107 39. 217 -69. 303 -92. 192 1.00 30. .37 B c

ATOM 11248 CDl LEU B 107 39. 749 -68. 219 -93. 101 1.00 24. ,93 B c

ATOM 11252 CD2 LEU B 107 39. 684 -69. 095 -90. 771 1.00 33. ,70 B c

ATOM 11256 C LEU B 107 35. 590 -68. 431 -93. 186 1.00 40. ,15 B c

ATOM 11257 O LEU B 107 34. 655 -69. 141 -92. 802 1.00 38. ,93 B 0

ATOM 11259 N LEU B 108 35. 617 -67. 851 -94. 379 1.00 42. ,05 B N

ATOM 11260 CA LEU B 108 34. 572 -68. 061 -95. 367 1.00 40. ,63 B c

ATOM 11262 CB LEU B 108 34. 027 -66. 720 -95. 868 1.00 41. ,05 B c

ATOM 11265 CG LEU B 108 33. 297 -65. 870 -94. 834 1.00 38, ,75 B c

ATOM 11267 CDl LEU B 108 32. 967 -64. 503 -95. 423 1.00 38. ,60 B c

ATOM 11271 CD2 LEU B 108 32. 049 -66. 577 -94. 335 1.00 38. ,22 B c

ATOM 11275 C LEU B 108 35. 175 -68. 825 -96. 517 1.00 38. ,65 B c

ATOM 11276 0 LEU B 108 36. 215 -68. 425 -97. 034 1.00 34. 86 B 0

ATOM 11278 N GLN B 109 34. 528 -69. 931 -96. 894 1.00 41. .50 B N

ATOM 11279 CA GLN B 109 34. 919 -70. 715 -98. 058 1.00 41.30 B c

ATOM 11281 CB GLN B 109 34. 588 -72. 181 -97. 835 1.00 42. ,46 B c

ATOM 11284 CG GLN B 109 35. 153 -73. 091 -98. 902 1.00 40. ,86 B c

ATOM 11287 CD GLN B 109 34. 876 -74. 548 -98. 621 1.00 41. ,42 B c

ATOM 11288 OEl GLN B 109 35. 635 -75. 423 -99. 043 1.00 39. ,42 B 0

ATOM 11289 NE2 GLN B 109 33. 790 -74. 820 -97. 895 1.00 39. ,58 B N

ATOM 11292 C GLN B 109 34. 175 -70. 249 -99. 300 1.00 40. .95 B c

ATOM 11293 0 GLN B 109 32. 957 -70. 094 -99. 273 1.00 42, ,76 B 0

ATOM 11295 N LEU B 110 34. 910 -70. 059- 100. 389 1.00 40. ,96 B N

ATOM 11296 CA LEU B 110 34. 327 -69. 643- 101. 659 1.00 42, .75 B c

ATOM 11298 CB LEU B 110 35. 320 -68. 784- ^• 102. 443 1.00 40. ,37 B C

ATOM 11301 CG LEU B 110 35. 955 -67. 610- 101. 699 1.00 37. ,73 B c

ATOM 11303 CDl LEU B 110 36. 882 -66. 842- ^■ 102. 633 1.00 37. ,30 B c

ATOM 11307 CD 2 LEU B 110 34. 893 -66. 707- ^■ 101. 107 1.00 33. ,94 B c

ATOM 11311 C LEU B 110 33. 934 -70. 865- ^■ 102. 495 1.00 45. ,66 B c

ATOM 11312 0 LEU B 110 34. 657 -71. 866- 102. 530 1.00 46. ,73 B 0

ATOM 11314 N SE B 111 32. 791 -70. 767- ^• 103. 176 1.00 49, ,04 B N

ATOM 11315 CA SER B 111 32. 243 -71.863- ^■ 103. 998 1.00 48, ,62 B c

ATOM 11317 CB SER B 111 30. 957 -71. 411- ^• 104. 699 1.00 49. ,22 B c

ATOM 11320 OG SER B 111 29. 899 -71.270- ^■ 103. 764 1.00 48, ,64 B 0

ATOM 11322 C SER B 111 33. 218 -72. 434- ^■ 105. 024 1.00 48. .30 B c

ATOM 11323 0 SER B 111 33. 028 -73. 552- ^■ 105. 491 1.00 50, .90 B 0

ATOM 11325 N GLU B 112 34. 239 -71. 662- 105. 386 1.00 49. .02 B N

ATOM 11326 CA GLU B 112 35. 342 -72. 168- 106. 191 1.00 52. .04 B c

ATOM 11328 CB GLU B 112 34. 983 -72. 126- 107. 681 1.00 54. ,27 B C

ATOM 11331 CG GLU B 112 34. 484 -70. 771- ^■ 108. 181 1.00 56. .58 B c

ATOM 11334 CD GLU B 112 34. 564 -70. ,635- ^■ 109. ,697 1.00 57, .28 B c

ATOM 11335 OEl GLU B 112 34. 192 -71. 591- ^• 110. ,417 1.00 57, ,99 B 0

ATOM 11336 OE2 GLU B 112 35. 007 -69. ,565- ^• 110. ,165 1.00 59, .49 B 0

ATOM 11337 C GLU B 112 36. 631 -71. ,387- ^■ 105. 929 1.00 51.93 B c

ATOM 11338 0 GLU B 112 36. 595 -70. 249- ^• 105. ,455 1.00 52, .44 B 0

ATOM 11340 N LYS B 113 37. 766 -72. 017- ^■ 106. 233 1.00 52, ,83 B N

ATOM 11341 CA LYS B 113 39. 072 -71.364- ^■ 106. ,149 1.00 52, .48 B c

ATOM 11343 CB LYS B 113 40. 196 -72. 328- -106. 543 1.00 53, .45 B c

ATOM 11346 CG LYS B 113 40. 395 -73. 504- ^■ 105. ,584 1.00 54, .09 B c

ATOM 11349 CD LYS B 113 41. 302 -74. 583- ^■ 106. 178 1.00 54, .33 B c

ATOM 11352 CE LYS B 113 42. 759 -74. ,143- ^■ 106. ,229 1.00 54, .82 B c

ATOM 11355 NZ LYS B 113 43. 638 -75. ,165- ^■ 106. ,881 1.00 53, .92 B N

ATOM 11359 C LYS B 113 39. 092 -70. ,151- ^■ 107. ,073 1.00 53, ,27 B c

ATOM 11360 0 LYS B 113 38. 843 -70. ,275- ^■ 108. ,272 1.00 57, .18 B 0

ATOM 11362 N ALA B 114 39. 381 -68. 985- ^• 106. ,505 1.00 51, .39 B N cyno fD_Fab

ATOM 11363 CA ALA B 114 39.364 -67. .724- 107. 240 1. 00 49. 30 B C

ATOM 11365 CB ALA B 114 39.438 -66. ,543- 106. 252 1. 00 50. 14 B C

ATOM 11369 C ALA B 114 40.510 -67. .646- 108. 238 1. 00 46. 01 B C

ATOM 11370 O ALA B 114 41.560 -68. ,261- 108. 036 1. 00 43. 29 B 0

ATOM 11372 N THR B 115 40.315 -66. ,886- ^• 109. ,313 1. 00 46. 36 B N

ATOM 11373 CA THR B 115 41.363 -66. ,748- 110. 329 1. 00 48. 03 B C

ATOM 11375 CB THR B 115 40.816 -66. ,289- 111. 710 1. 00 48. 67 B C

ATOM 11377 OGl THR B 115 39.528 -66. ,873- 111. 944 1. 00 50. 37 B 0

ATOM 11379 CG2 THR B 115 41.782 -66. ,692- ^• 112. 842 1. 00 45. 96 B C

ATOM 11383 C THR B 115 42.426 -65. ,768- 109. 838 1. 00 46. 66 B c

ATOM 11384 O THR B 115 42.138 -64. ,596- 109. 582 1. 00 46. 92 B 0

ATOM 11386 N LEU B 116 43.646 -66. ,276- 109. 695 1. 00 46. 90 B N

ATOM 11387 CA LEU B 116 44.787 -65, ,481- 109. 254 1. 00 48. 21 B c

ATOM 11389 CB LEU B 116 45.867 -66. ,379- 108. 619 1. 00 47. 80 B c

ATOM 11392 CG LEU B 116 45.751 -66. ,649- 107. 114 1. 00 46. 50 B c

ATOM 11394 CDl LEU B 116 44.349 -67. ,133- 106. 714 1. 00 45. 05 B c

ATOM 11398 CD2 LEU B 116 46.821 -67. ,645- 106. 683 1. 00 47. 63 B c

ATOM 11402 C LEU B 116 45.393 -64. ,680- ^■ 110. 412 1. 00 50. 28 B c

ATOM 11403 O LEU B 116 45.627 -65. ,215- 111. 505 1. 00 51. 04 B 0

ATOM 11405 N GLY B 117 45.640 -63. ,398- 110. 155 1. 00 50. 18 B N

ATOM 11406 CA GLY B 117 46.328 -62. ,514- 111. 099 1. 00 49. 80 B c

ATOM 11409 C GLY B 117 46.903 -61. .316- 110. 363 1. 00 51. 23 B c

ATOM 11410 O GLY B 117 46.903 -61. .284- 109. 128 1. 00 52. 42 B 0

ATOM 11412 N PRO B 118 47.411 -60. 321- ^• 111. 109 1. 00 50. 57 B N

ATOM 11413 CA PRO B 118 47.839 -59. ,053- 110. 508 1. 00 48. 91 B c

ATOM 11415 CB PRO B 118 47.901 -58. ,112- 111. 720 1. 00 49. 04 B c

ATOM 11418 CG PRO B 118 48.293 -59. ,008- 112. 856 1. 00 50. 73 B c

ATOM 11421 CD PRO B 118 47.652 -60. ,349- 112. 567 1. 00 51. 39 B c

ATOM 11424 C PRO B 118 46.892 -58. ,489- 109. 416 1. 00 47. 46 B c

ATOM 11425 O PRO B 118 47.365 -57. 899- 108. 435 1. 00 49. 48 B 0

ATOM 11426 N ALA B 119 45.582 -58. ,693- ^• 109. 583 1. 00 44. 58 B N

ATOM 11427 CA ALA B 119 44.566 -58. ,084- 108. 720 1. 00 42. 93 B c

ATOM 11429 CB ALA B 119 43.510 -57. ,395- 109. 582 1. 00 41.17 B c

ATOM 11433 C ALA B 119 43.884 -59. ,040- 107. 738 1. 00 39. 52 B c

ATOM 11434 O ALA B 119 43.041 -58. ,607- 106. 952 1. 00 37. 52 B 0

ATOM 11436 N VAL B 120 44.217 -60. ,328- 107. 790 1. 00 38. 53 B N

ATOM 11437 CA VAL B 120 43.726 -61. 292- 106. 791 1. 00 40. 55 B c

ATOM 11439 CB VAL B 120 42.462 -62. ,067- 107. 281 1. 00 36. 70 B c

ATOM 11441 CGI VAL B 120 41.940 -63. ,001- 106. 186 1. 00 35. 55 B c

ATOM 11445 CG2 VAL B 120 41.356 -61.100- 107. 718 1. 00 30. 29 B c

ATOM 11449 C VAL B 120 44.858 -62. ,260- 106. 379 1. 00 41. 98 B c

ATOM 11450 O VAL B 120 45.413 -62. ,971- 107. ,215 1. 00 42. 33 B 0

ATOM 11452 N ARG B 121 45.205 -62. .261- 105. 090 1. 00 44. 37 B N

ATOM 11453 CA ARG B 121 46.329 -63. ,059- 104. 584 1. 00 44. 25 B c

ATOM 11455 CB ARG B 121 47.656 -62. ,403- ^• 104. 978 1. 00 45. 39 B c

ATOM 11458 CG ARG B 121 48.897 -63. ,289- 104. 806 1. 00 47. 79 B c

ATOM 11461 CD ARG B 121 50.160 -62. ,514- 105. 159 1. 00 50. 33 B c

ATOM 11464 NE ARG B 121 49.955 -61. ,682- 106. 349 1. 00 53. 92 B N

ATOM 11466 cz ARG B 121 50.021 -62. ,112- ^• 107. ,615 1. 00 56. 26 B c

ATOM 11467 NHl ARG B 121 50.305 -63. ,384- ^■ 107. ,904 1. 00 57. ,13 B N

ATOM 11470 NH2 ARG B 121 49.808 -61.254- 108. ,611 1. 00 55. 53 B N

ATOM 11473 C ARG B 121 46.248 -63. ,168- ^• 103. 063 1. 00 40. 77 B c

ATOM 11474 O ARG B 121 46.069 -62. ,153- 102. ,401 1. 00 43. 84 B 0

ATOM 11476 N PRO B 122 46.406 -64. ,385- 102. 500 1. 00 39. 83 B N

ATOM 11477 CA PRO B 122 46.275 -64. ,491- 101. 045 1. 00 40. 66 B C

ATOM 11479 CB PRO B 122 46.121 -66. .004- 100. 790 1. 00 40. ,42 B C

ATOM 11482 CG PRO B 122 46.283 -66. ,689- ^• 102. ,114 1. 00 40. 82 B C

ATOM 11485 CD PRO B 122 46.745 -65. ,681- 103. 119 1. 00 41. ,88 B c

ATOM 11488 C PRO B 122 47.496 -63. ,927- ^• 100. 307 1. 00 39. 03 B c

ATOM 11489 O PRO B 122 48.611 -63. ,920- 100. 850 1. 00 39. ,15 B 0

ATOM 11490 N LEU B 123 47.270 -63. ,458 -99. 083 1. 00 37. 40 B N

ATOM 11491 CA LEU B 123 48.318 -62. ,808 -98. 293 1. 00 36. 54 B c

ATOM 11493 CB LEU B 123 47.740 -61. ,604 -97. 553 1. 00 34. 60 B c

ATOM 11496 CG LEU B 123 48.687 -60. ,681 -96. ,784 1. 00 32. ,58 B c

ATOM 11498 CDl LEU B 123 47.860 -59. ,601 -96. 160 1. 00 25. ,32 B c

ATOM 11502 CD2 LEU B 123 49.779 -60. ,082 -97. ,690 1. 00 32. ,13 B c

ATOM 11506 C LEU B 123 48.936 -63. ,770 -97. ,283 1. 00 34. ,27 B c

ATOM 11507 O LEU B 123 48.206 -64. ,391 -96. ,498 1. 00 31.78 B 0 cyno fD_Fab

ATOM 11509 N PRO B 124 50. .280 -63. ,893 -97. 297 1. 00 32. 59 B N

ATOM 11510 CA PRO B 124 50. ,990 -64. .591 -96. 225 1. 00 34. 78 B C

ATOM 11512 CB PRO B 124 52. ,472 -64. ,328 -96. 541 1. 00 34. 18 B C

ATOM 11515 CG PRO B 124 52. 506 -64. .085 -97. 999 1. 00 35. 47 B C

ATOM 11518 CD PRO B 124 51. ,205 -63. ,409 -98. 339 1. 00 33. 59 B c

ATOM 11521 C PRO B 124 50. 630 -64. .034 -94. 847 1. 00 32. 21 B c

ATOM 11522 0 PRO B 124 50. ,732 -62. .826 -94. 619 1. 00 27. 23 B 0

ATOM 11523 N TRP B 125 50. ,217 -64. ,924 -93. 953 1. 00 32. 05 B N

ATOM 11524 CA TRP B 125 49. 784 -64. ,554 -92. 615 1. 00 34. 23 B c

ATOM 11526 CB TRP B 125 48. 371 -65. ,103 -92. 331 1. 00 34. 29 B c

ATOM 11529 CG TRP B 125 48. 195 -66. .586 -92. 482 1. 00 35. 41 B c

ATOM 11530 CDl TRP B 125 47. ,992 -67. ,282 -93. 646 1. 00 36. 40 B c

ATOM 11532 NEl TRP B 125 47. ,873 -68. .627 -93. 380 1. 00 36. 37 B N

ATOM 11534 CE2 TRP B 125 47. ,992 -68. ,822 -92. 030 1. 00 37. 31 B c

ATOM 11535 CD2 TRP B 125 48. ,193 -67. ,557 -91.434 1. 00 36. 10 B c

ATOM 11536 CE3 TRP B 125 48. 358 -67. ,485 -90. 052 1. 00 35. 45 B c

ATOM 11538 CZ3 TRP B 125 48. 309 -68. ,650 -89. 316 1. 00 35. 37 B c

ATOM 11540 CH2 TRP B 125 48. 099 -69. ,887 -89. 927 1. 00 34. 82 B c

ATOM 11542 CZ2 TRP B 125 47. ,940 -69. ,997 -91.284 1. 00 36. 30 B c

ATOM 11544 C TRP B 125 50. 815 -64. ,998 -91. 564 1. 00 35. 21 B c

ATOM 11545 0 TRP B 125 51. 567 -65. ,952 -91. 786 1. 00 39. 04 B 0

ATOM 11547 N GLN B 126 50. 874 -64. ,279 -90. 440 1. 00 33. 62 B N

ATOM 11548 CA GLN B 126 51. 883 -64. .552 -89. 406 1. 00 33. 70 B c

ATOM 11550 CB GLN B 126 52. ,055 -63. ,396 -88. 407 1. 00 31. 61 B c

ATOM 11553 CG GLN B 126 53. 242 -63. .609 -87. 424 1. 00 28. 87 B c

ATOM 11556 CD GLN B 126 54. 593 -63. ,756 -88. 130 1. 00 28. 85 B c

ATOM 11557 OEl GLN B 126 55. 110 -64. .859 -88. 285 1. 00 30. 93 B 0

ATOM 11558 NE2 GLN B 126 55. 150 -62. ,645 -88. 573 1. 00 30. 67 B N

ATOM 11561 C GLN B 126 51. 566 -65. ,813 -88. 630 1. 00 33. 71 B c

ATOM 11562 0 GLN B 126 50. 486 -65. ,950 -88. 037 1. 00 33. 51 B 0

ATOM 11564 N ARG B 127 52. 563 -66. ,688 -88. 608 1. 00 31. 77 B N

ATOM 11565 CA ARG B 127 52. 469 -68. ,033 -88. 072 1. 00 33. 43 B c

ATOM 11567 CB ARG B 127 53. 161 -68. ,965 -89. 068 1. 00 33. 90 B c

ATOM 11570 CG ARG B 127 53. 176 -70. ,433 -88. 690 1. 00 39. 72 B c

ATOM 11573 CD ARG B 127 53. 622 -71. ,280 -89. 881 1. 00 41. 87 B c

ATOM 11576 NE ARG B 127 52. 650 -71. .168 -90.970 1. 00 45. 09 B N

ATOM 11578 CZ ARG B 127 51.514 -71. ,856 -91. 048 1. 00 44. 24 B c

ATOM 11579 NH1 ARG B 127 51. 193 -72. 740 -90. 109 1. 00 43. 32 B N

ATOM 11582 NH2 ARG B 127 50. 695 -71.659 -92. 075 1. 00 42. 33 B N

ATOM 11585 C ARG B 127 53. 129 -68. ,168 -86. 695 1. 00 30. 09 B C

ATOM 11586 0 ARG B 127 52. 744 -69. 034 -85. 892 1. 00 26. 87 B 0

ATOM 11588 N VAL B 128 54. 142 -67. ,330 -86. 455 1. 00 26. 17 B N

ATOM 11589 CA VAL B 128 54. 966 -67. ,381 -85. 247 1. 00 24. 60 B C

ATOM 11591 CB VAL B 128 56. 424 -66. ,916 -85. 551 1. 00 20. 93 B c

ATOM 11593 CGI VAL B 128 57. 298 -66. ,974 -84. 310 1. 00 17. ,45 B c

ATOM 11597 CG2 VAL B 128 57. 041 -67. .748 -86. 713 1. 00 17. 68 B c

ATOM 11601 C VAL B 128 54. ,311 -66. .450 -84. 232 1. 00 21.94 B c

ATOM 11602 0 VAL B 128 54. 173 -65. ,252 -84. 491 1. 00 22. 55 B 0

ATOM 11604 N ASP B 129 53. 875 -67. Oil -83. 109 1. 00 18. 70 B N

ATOM 11605 CA ASP B 129 53. 161 -66, ,257 -82. 092 1. 00 23. 72 B c

ATOM 11607 CB ASP B 129 52. 415 -67. .214 -81. 159 1. 00 24. 41 B c

ATOM 11610 CG ASP B 129 51.400 -66. ,528 -80. 296 1. 00 25. 51 B c

ATOM 11611 001 ASP B 129 51. 250 -65. ,297 -80. 378 1. 00 29. 26 B 0

ATOM 11612 OD2 ASP B 129 50. 727 -67. ,224 -79. 519 1. 00 26. 23 B 0

ATOM 11613 C ASP B 129 54. 168 -65. ,391 -81. 336 1. 00 23. 86 B c

ATOM 11614 0 ASP B 129 54. 766 -65. .810 -80. 348 1. 00 21. 25 B 0

ATOM 11616 N ARG B 130 54. 382 -64. .196 -81. 865 1. 00 26. ,50 B N

ATOM 11617 CA ARG B 130 55. ,261 -63. ,200 -81. 269 1. 00 28. ,45 B c

ATOM 11619 CB ARG B 130 56. ,670 -63. ,300 -81. 867 1. 00 28. ,36 B c

ATOM 11622 CG ARG B 130 57. ,737 -62. ,612 -81. 035 1. 00 32. ,41 B c

ATOM 11625 CD ARG B 130 59. ,078 -62. ,489 -81.761 1. 00 39. 23 B c

ATOM 11628 NE ARG B 130 59. 910 -63. ,697 -81. 704 1. 00 43. ,31 B N

ATOM 11630 CZ ARG B 130 60. 155 -64. ,511 -82. 734 1. 00 46. ,13 B C

ATOM 11631 NHl ARG B 130 59. 630 -64. ,278 -83. 942 1. 00 45. ,77 B N

ATOM 11634 NH2 ARG B 130 60. 937 -65. ,577 -82. 555 1. 00 46. ,50 B N

ATOM 11637 C ARG B 130 54. 657 -61. ,838 -81. 581 1. 00 25. ,04 B C

ATOM 11638 0 ARG B 130 54. 446 -61. ,515 -82. 749 1. 00 21. 19 B 0

ATOM 11640 N ASP B 131 54. 362 -61. .064 -80. ,543 1. 00 24. ,39 B N cyno fD_Fab

ATOM 11641 CA ASP B 131 53. ,761 -59. ,739 -80. 689 1. 00 23. ,69 B C

ATOM 11643 CB ASP B 131 53. ,849 -58. ,962 -79. 380 1. 00 23. ,97 B C

ATOM 11646 CG ASP B 131 52. ,866 -59. ,419 -78. 369 1. 00 22. ,63 B C

ATOM 11647 ODl ASP B 131 51. ,935 -60. ,139 -78. 743 1. 00 25. 98 B 0

ATOM 11648 OD2 ASP B 131 53. ,020 -59. ,044 -77. 192 1. 00 25. ,21 B 0

ATOM 11649 C ASP B 131 54. ,455 -58. ,904 -81. 732 1. 00 22. ,63 B c

ATOM 11650 0 ASP B 131 55. ,676 -58. ,942 -81. 840 1. 00 25. ,47 B 0

ATOM 11652 N VAL B 132 53. ,672 -58. ,159 -82. 503 1. 00 20. ,80 B N

ATOM 11653 CA VAL B 132 54. ,218 -57. ,057 -83. 278 1. 00 19. ,03 B C

ATOM 11655 CB VAL B 132 53. ,214 -56. ,499 -84. 325 1. 00 19. ,19 B C

ATOM 11657 CGI VAL B 132 53. ,756 -55. ,225 -84. 981 1. 00 18. ,01 B c

ATOM 11661 CG2 VAL B 132 52. ,940 -57. ,543 -85. 412 1. 00 14. ,19 B c

ATOM 11665 C VAL B 132 54. 614 -56. ,005 -82. 245 1. 00 22. ,76 B c

ATOM 11666 0 VAL B 132 53. 875 -55. ,718 -81.290 1. 00 16. ,29 B 0

ATOM 11668 N GLU B 133 55. 806 -55. ,459 -82. 407 1. 00 22. ,76 B N

ATOM 11669 CA GLU B 133 56. ,359 -54. ,556 -81. 401 1. 00 20. ,31 B c

ATOM 11671 CB GLU B 133 57. ,835 -54. ,332 -81. 681 1. 00 18. ,25 B c

ATOM 11674 CG GLU B 133 58. 627 -55. ,540 -81. 396 1. 00 17. ,67 B c

ATOM 11677 CD GLU B 133 60. 012 -55. ,429 -81. 911 1. 00 15. ,27 B c

ATOM 11678 OEl GLU B 133 60. 338 -54. 365 -82. 482 1. 00 18. ,17 B 0

ATOM 11679 OE2 GLU B 133 60. 766 -56. ,403 -81. 738 1. 00 14. ,57 B 0

ATOM 11680 C GLU B 133 55. 673 -53. 223 -81.407 1. 00 16. ,40 B c

ATOM 11681 0 GLU B 133 55. 391 -52. ,713 -82. 486 1. 00 11.97 B 0

ATOM 11683 N PRO B 134 55. 412 -52. ,650 -80. 201 1. 00 15. ,37 B N

ATOM 11684 CA PRO B 134 54. 860 -51. ,315 -80. 076 1. 00 17. ,80 B C

ATOM 11686 CB PRO B 134 55. ,137 -50. ,949 -78. 609 1. 00 16. ,82 B c

ATOM 11689 CG PRO B 134 55. 266 -52. 233 -77. 898 1. 00 17. ,07 B c

ATOM 11692 CD PRO B 134 55. 671 -53. 265 -78. 882 1. 00 16. ,65 B c

ATOM 11695 C PRO B 134 55. 577 -50. 332 -80. 987 1. 00 17. ,30 B c

ATOM 11696 0 PRO B 134 56. 811 -50. 343 -81. 073 1. 00 21. ,19 B 0

ATOM 11697 N GLY B 135 54. 807 -49. ,501 -81. 668 1. 00 18. ,47 B N

ATOM 11698 CA GLY B 135 55. 370 -48. 488 -82. 531 1. 00 19. ,00 B C

ATOM 11701 C GLY B 135 55. 460 -48. ,896 -83. 977 1. 00 17. ,35 B c

ATOM 11702 0 GLY B 135 55. 489 -48. ,036 -84. 845 1. 00 27. ,90 B 0

ATOM 11704 N THR B 136 55. ,497 -50. ,194 -84. 266 1. 00 20. ,52 B N

ATOM 11705 CA THR B 136 55. 588 -50. ,629 -85. 661 1. 00 22. ,00 B c

ATOM 11707 CB THR B 136 55. 579 -52. ,179 -85. 827 1. 00 18. ,31 B c

ATOM 11709 OGl THR B 136 56. 321 -52. ,804 -84. 762 1. 00 13. ,04 B 0

ATOM 11711 CG2 THR B 136 56. 203 -52. ,574 -87. 172 1. 00 18. ,38 B c

ATOM 11715 C THR B 136 54. 414 -50. ,034 -86. 443 1. 00 23. ,24 B c

ATOM 11716 0 THR B 136 53. 261 -50. ,090 -85. 986 1. 00 24. ,17 B 0

ATOM 11718 N LEU B 137 54. 718 -49. ,440 -87. 595 1. 00 23. ,72 B N

ATOM 11719 CA LEU B 137 53. ,699 -48. ,917 -88. ,496 1. 00 24. ,22 B c

ATOM 11721 CB LEU B 137 54. ,286 -47. ,849 -89. ,424 1. 00 25. ,95 B c

ATOM 11724 CG LEU B 137 54. ,947 -46. ,636 -88. 754 1. 00 30. ,15 B c

ATOM 11726 CDl LEU B 137 55. 655 -45. ,771 -89. 793 1. 00 29. ,17 B c

ATOM 11730 CD2 LEU B 137 53. ,939 -45. ,810 -87. 979 1. 00 26. .86 B c

ATOM 11734 C LEU B 137 53. ,117 -50. ,047 -89. 337 1. 00 23. .10 B c

ATOM 11735 0 LEU B 137 53. 832 -50. ,670 -90. 122 1. 00 27. .08 B 0

ATOM 11737 N CYS B 138 51.818 -50. ,287 -89. 183 1. 00 25. ,84 B N

ATOM 11738 CA CYS B 138 51. 112 -51.326 -89. 933 1. 00 27. ,63 B c

ATOM 11740 CB CYS B 138 50. ,395 -52. .288 -88. ,979 1. 00 27. ,57 B c

ATOM 11743 SG CYS B 138 51. ,412 -53. ,304 -87. 825 1. 00 29. ,65 B S

ATOM 11745 C CYS B 138 50. ,084 -50. ,696 -90. ,877 1. 00 24. ,10 B c

ATOM 11746 0 CYS B 138 49. 595 -49. ,608 -90. ,627 1. 00 19. ,77 B 0

ATOM 11748 N ASP B 139 49. 753 -51. ,392 -91. ,960 1. 00 23. ,67 B N

ATOM 11749 CA ASP B 139 48. 785 -50. ,902 -92. ,941 1. 00 22. ,41 B c

ATOM 11751 CB ASP B 139 49. 328 -51. ,204 -94. ,344 1. 00 30. ,30 B c

ATOM 11754 CG ASP B 139 48. 369 -50. ,804 -95. ,445 1. 00 31.38 B c

ATOM 11755 ODl ASP B 139 48. ,266 -49. ,593 -95. ,735 1. 00 31.27 B 0

ATOM 11756 OD2 ASP B 139 47. 732 -51. ,720 -96. ,016 1. 00 37. ,08 B 0

ATOM 11757 C ASP B 139 47. ,424 -51.582 -92. ,715 1. 00 21.74 B c

ATOM 11758 0 ASP B 139 47. 369 -52. ,791 -92. ,620 1. 00 25, ,00 B 0

ATOM 11760 N VAL B 140 46. 340 -50. ,806 -92. ,571 1. 00 27, ,87 B N

ATOM 11761 CA VAL B 140 44. ,958 -51. ,351 -92. ,520 1. 00 23. ,33 B c

ATOM 11763 CB VAL B 140 44. 256 -51. ,057 -91.178 1. 00 23. ,44 B c

ATOM 11765 CGI VAL B 140 44. ,178 -49. ,566 -90. ,929 1. 00 23. ,51 B c

ATOM 11769 CG2 VAL B 140 42. 862 -51. ,662 -91. ,187 1. 00 23. ,35 B c cyno fD_Fab

ATOM 11773 C VAL B 140 44. ,095 -50. 762 -93. ,644 1.00 25. ,55 B C

ATOM 11774 O VAL B 140 44. ,131 -49. 556 -93. ,878 1.00 26. 66 B 0

ATOM 11776 N ALA B 141 43. ,317 -51. 611 -94. ,321 1.00 28. ,46 B N

ATOM 11777 CA ALA B 141 42. ,506 -51. 212 -95. ,481 1.00 27. ,18 B C

ATOM 11779 CB ALA B 141 43. ,079 -51. 819 -96. ,741 1.00 25. ,46 B c

ATOM 11783 C ALA B 141 41. ,035 -51. 604 -95. ,327 1.00 28. ,30 B c

ATOM 11784 O ALA B 141 40. ,699 -52. 565 -94. ,632 1.00 26. ,48 B 0

ATOM 11786 N GLY B 142 40. ,154 -50. 848 -95. ,979 1.00 31. 86 B N

ATOM 11787 CA GLY B 142 38. 715 -51. 118 -95. ,914 1.00 31.54 B c

ATOM 11790 C GLY B 142 37. 807 -50. 119 -96. ,635 1.00 33. 87 B c

ATOM 11791 O GLY B 142 38. ,220 -49. 012 -97. .000 1.00 33. ,90 B 0

ATOM 11793 N TRP B 143 36. ,564 -50. 545 -96. ,851 1.00 32. ,79 B N

ATOM 11794 CA TRP B 143 35. ,511 -49. 701 -97. 408 1.00 29. ,63 B c

ATOM 11796 CB TRP B 143 34. 685 -50. 448 -98. 474 1.00 26. ,76 B c

ATOM 11799 CG TRP B 143 35. ,401 -50. 828 -99. ,744 1.00 26. ,59 B c

ATOM 11800 CDl TRP B 143 35. ,463 -50. 107- 100. 896 1.00 25. ,81 B c

ATOM 11802 NEl TRP B 143 36. 190 -50. 791- ^■ 101. ,850 1.00 28. 24 B N

ATOM 11804 CE2 TRP B 143 36. ,600 -51. 986- ^■ 101. ,320 1.00 30. ,12 B c

ATOM 11805 CD2 TRP B 143 36. ,109 -52. 049 -99. ,993 1.00 28. ,49 B c

ATOM 11806 CE3 TRP B 143 36. ,391 -53. 183 -99. 220 1.00 27. ,79 B c

ATOM 11808 CZ3 TRP B 143 37. 141 -54. 207 -99. ,789 1.00 26. 22 B c

ATOM 11810 CH2 TRP B 143 37. 611 -54. 117- ^■ 101. ,109 1.00 26. ,40 B c

ATOM 11812 CZ2 TRP B 143 37. 353 -53. 016- 101.888 1.00 27. ,88 B c

ATOM 11814 C TRP B 143 34. 589 -49. 300 -96. 264 1.00 28. ,31 B c

ATOM 11815 O TRP B 143 33. 396 -49. 120 -96. ,471 1.00 31. 03 B 0

ATOM 11817 N GLY B 144 35. ,138 -49. 170 -95. ,057 1.00 30. ,95 B N

ATOM 11818 CA GLY B 144 34. 359 -48. 766 -93. ,887 1.00 28. ,10 B c

ATOM 11821 C GLY B 144 34. ,142 -47. 272 -93. ,898 1.00 25. 72 B c

ATOM 11822 O GLY B 144 34. 825 -46. 555 -94. ,639 1.00 23. ,47 B 0

ATOM 11824 N ILE B 145 33. ,214 -46. 798 -93. ,063 1.00 29. ,43 B N

ATOM 11825 CA ILE B 145 32. 906 -45. 360 -92. ,970 1.00 33. 48 B c

ATOM 11827 CB ILE B 145 31. 805 -45. 016 -91.875 1.00 34. 96 B c

ATOM 11829 CGI ILE B 145 32. 240 -45. 405 -90. ,455 1.00 35. ,09 B c

ATOM 11832 CDl ILE B 145 31. ,175 -45. 095 -89. ,339 1.00 30. 59 B c

ATOM 11836 CG2 ILE B 145 30. ,473 -45. 698 -92. ,215 1.00 34. ,74 B c

ATOM 11840 C ILE B 145 34. 202 -44. 570 -92. ,754 1.00 37. ,06 B c

ATOM 11841 0 ILE B 145 35. ,143 -45. 046 -92. ,102 1.00 42. ,92 B 0

ATOM 11843 N VAL B 146 34. ,256 -43. 373 -93. ,326 1.00 37. ,33 B N

ATOM 11844 CA VAL B 146 35. 512 -42. 631 -93. ,458 1.00 38. ,16 B c

ATOM 11846 CB VAL B 146 35. 520 -41. 823 -94. .788 1.00 39. ,60 B c

ATOM 11848 CGI VAL B 146 35. 030 -40. 390 -94. ,567 1.00 40. ,07 B c

ATOM 11852 CG2 VAL B 146 36. ,896 -41. 862 -95. ,437 1.00 40. .03 B c

ATOM 11856 C VAL B 146 35. ,765 -41.754 -92. ,224 1.00 38. ,99 B c

ATOM 11857 0 VAL B 146 36. ,832 -41. 151 -92. ,075 1.00 36. ,62 B 0

ATOM 11859 N SER B 147 34. ,761 -41.716 -91. ,348 1.00 37. ,10 B N

ATOM 11860 CA SER B 147 34. 805 -41. 049 -90, .060 1.00 41. .77 B c

ATOM 11862 CB SER B 147 34. ,767 -39. 519 -90. .218 1.00 43. ,69 B c

ATOM 11865 OG SER B 147 33. ,446 -39. 012 -90, ,142 1.00 43. ,39 B 0

ATOM 11867 C SER B 147 33. ,568 -41. 601 -89. ,317 1.00 43. ,56 B c

ATOM 11868 0 SER B 147 32. ,815 -42. ,394 -89, .901 1.00 42. ,52 B 0

ATOM 11870 N HIS B 148 33. ,334 -41. ,210 -88, ,066 1.00 44. ,75 B N

ATOM 11871 CA HIS B 148 32. ,315 -41. 909 -87. .264 1.00 49, ,26 B c

ATOM 11873 CB HIS B 148 32. 634 -41. 872 -85, ,758 1.00 51. ,25 B c

ATOM 11876 CG HIS B 148 31. ,931 -40. 790 -84. .991 1.00 52, ,87 B c

ATOM 11877 NDl HIS B 148 32. ,541 -39. 601 -84. .651 1.00 51. ,31 B N

ATOM 11879 CEl HIS B 148 31. ,694 -38. 861 -83, ,957 1.00 53. ,25 B c

ATOM 11881 NE2 HIS B 148 30. ,561 -39. 528 -83. ,826 1.00 52. ,81 B N

ATOM 11883 CD2 HIS B 148 30. ,686 -40. ,743 -84, ,456 1.00 53. ,25 B c

ATOM 11885 C HIS B 148 30. ,859 -41. ,494 -87, .539 1.00 55, ,00 B c

ATOM 11886 0 HIS B 148 29. ,949 -42. 323 -87, .386 1.00 56, ,71 B 0

ATOM 11888 N ALA B 149 30. ,631 -40. 230 -87, ,911 1.00 56. ,32 B N

ATOM 11889 CA ALA B 149 29. ,295 -39. 782 -88. ,339 1.00 56, ,03 B c

ATOM 11891 CB ALA B 149 29. ,225 -38. 259 -88. ,442 1.00 58, ,52 B C

ATOM 11895 C ALA B 149 29. ,047 -40. ,441 -89. .689 1.00 56, ,29 B c

ATOM 11896 0 ALA B 149 27. ,959 -40. ,947 -89, .964 1.00 59, .70 B 0

ATOM 11898 N GLY B 150 30. ,077 -40. ,399 -90, .527 1.00 54, .27 B N

ATOM 11899 CA GLY B 150 30. ,397 -41. ,517 -91.400 1.00 52. .28 B c

ATOM 11902 C GLY B 150 29. ,803 -41. 613 -92, ,779 1.00 49. .92 B c cyno fD_Fab

ATOM 11903 O GLY B 150 28 659 -42. 041 -92. ,938 1.00 53. 45 B 0

ATOM 11905 N ARG B 151 30. 619 -41. 264 -93. ,771 1.00 47. 78 B N

ATOM 11906 CA ARG B 151 30. 311 -41. 498 -95. ,179 1.00 50. 13 B C

ATOM 11908 CB ARG B 151 30. 808 -40. 298 -96. ,009 1.00 50. 96 B C

ATOM 11911 CG ARG B 151 31. 381 -40. 595 -97. 407 1.00 49. 67 B C

ATOM 11914 CD ARG B 151 32 576 -39. 689 -97. ,676 1.00 52. 44 B c

ATOM 11917 NE ARG B 151 32 994 -39. 687 -99. ,079 1.00 52. 08 B N

ATOM 11919 CZ ARG B 151 34 252 -39. 772 -99. ,519 1.00 54. 56 B c

ATOM 11920 NHl ARG B 151 35. 283 -39. 873 -98. ,684 1.00 56. 41 B N

ATOM 11923 NH2 ARG B 151 34. 489 -39. 743- 100. ,827 1.00 55. 57 B N

ATOM 11926 C ARG B 151 30. 972 -42. 811 -95. ,631 1.00 47. 73 B C

ATOM 11927 O ARG B 151 32. 181 -42. 976 -95. ,480 1.00 44. 04 B 0

ATOM 11929 N ARG B 152 30. 174 -43. 736 -96. 175 1.00 49. 35 B N

ATOM 11930 CA ARG B 152 30 678 -44. 996 -96. ,760 1.00 48. 01 B C

ATOM 11932 CB ARG B 152 29. 527 -45. 995 -96. ,963 1.00 54. 94 B C

ATOM 11935 CG ARG B 152 28. 912 -46. 567 -95. ,677 1.00 59. 29 B c

ATOM 11938 CD ARG B 152 29. 523 -47. 943 -95. ,296 1.00 63. 53 B c

ATOM 11941 NE ARG B 152 28. 917 -48. 530 -94. ,087 1.00 63. 81 B N

ATOM 11943 CZ ARG B 152 29. 251 -49. 708 -93. ,555 1.00 63. 55 B c

ATOM 11944 NHl ARG B 152 30. 198 -50. 456 -94. ,116 1.00 65. 67 B N

ATOM 11947 NH2 ARG B 152 28. 634 -50. 142 -92. 458 1.00 63. 17 B N

ATOM 11950 C ARG B 152 31 324 -44. 717 -98. ,118 1.00 43. 24 B C

ATOM 11951 O ARG B 152 30. 646 -44. 214 -99. ,008 1.00 44. 71 B 0

ATOM 11953 N PRO B 153 32. 625 -45. 037 -98. ,294 1.00 38. 63 B N

ATOM 11954 CA PRO B 153 33. 263 -44. 787 -99. 592 1.00 39. 93 B C

ATOM 11956 CB PRO B 153 34. 747 -44. 648 -99. 235 1.00 35. 61 B c

ATOM 11959 CG PRO B 153 34. 917 -45. 520 -98. 042 1.00 38. 02 B c

ATOM 11962 CD PRO B 153 33. 581 -45. 599 -97. 325 1.00 38. 62 B c

ATOM 11965 C PRO B 153 33. 079 -45. 906- 100. 620 1.00 43. 13 B c

ATOM 11966 0 PRO B 153 32 858 -47. 070- ^■ 100. ,264 1.00 44. 56 B 0

ATOM 11967 N ASP B 154 33. 193 -45. 530- ^• 101. ,891 1.00 41. 28 B N

ATOM 11968 CA ASP B 154 33. 048 -46. 460- 102. 989 1.00 40. 63 B c

ATOM 11970 CB ASP B 154 32. 655 -45. 723- ^■ 104. ,270 1.00 39. 03 B c

ATOM 11973 CG ASP B 154 32. 139 -46. 660- 105. 326 1.00 37. 49 B c

ATOM 11974 ODl ASP B 154 31. 084 -47. 279- ^■ 105. ,064 1.00 35. 40 B 0

ATOM 11975 OD2 ASP B 154 32. 794 -46. 789- 106. ,390 1.00 36. 37 B 0

ATOM 11976 C ASP B 154 34. 348 -47. 220- ^■ 103. ,226 1.00 39. 41 B c

ATOM 11977 0 ASP B 154 34 325 -48. 436- ^■ 103. ,395 1.00 40. 01 B 0

ATOM 11979 N ARG B 155 35 471 -46. 501- ^■ 103. ,246 1.00 40. 14 B N

ATOM 11980 CA ARG B 155 36. 781 -47. 121- ^■ 103. ,488 1.00 39. 29 B c

ATOM 11982 CB ARG B 155 37. 623 -46. 398- •104. ,562 1.00 41. 67 B c

ATOM 11985 CG ARG B 155 37. 232 -44. 963- -104. ,934 1.00 45. 16 B c

ATOM 11988 CD ARG B 155 37. 405 -44. 699- ^• 106. ,437 1.00 44. 03 B c

ATOM 11991 NE ARG B 155 37. 971 -43. 378- 106. ,697 1.00 47. 23 B N

ATOM 11993 CZ ARG B 155 37. 330 -42. 218- ^• 106. ,543 1.00 47. 79 B c

ATOM 11994 NHl ARG B 155 36 060 -42. 178- ^■ 106. ,132 1.00 46. 07 B N

ATOM 11997 NH2 ARG B 155 37 972 -41. 081- ^■ 106. ,808 1.00 47. 12 B N

ATOM 12000 C ARG B 155 37 566 -47. 332- -102. ,193 1.00 38. 26 B C

ATOM 12001 0 ARG B 155 37 285 -46. ,721- ^• 101. ,156 1.00 36. 67 B 0

ATOM 12003 N LEU B 156 38. 534 -48. ,239- 102. ,257 1.00 35. 66 B N

ATOM 12004 CA LEU B 156 39. 175 -48. 737- -101. ,045 1.00 34. 73 B C

ATOM 12006 CB LEU B 156 39. 864 -50. 073- ^■ 101. ,325 1.00 32. 14 B c

ATOM 12009 CG LEU B 156 40. 467 -50. 836- -100. ,140 1.00 26. 36 B c

ATOM 12011 CDl LEU B 156 39 442 -51.728 -99. .469 1.00 17. 99 B c

ATOM 12015 CD2 LEU B 156 41.650 -51. ,649- -100. ,636 1.00 26. ,90 B c

ATOM 12019 C LEU B 156 40 173 -47. ,725- -100. ,483 1.00 34. ,63 B c

ATOM 12020 0 LEU B 156 41 003 -47. ,174- ^■ 101.219 1.00 30. ,74 B 0

ATOM 12022 N GLN B 157 40 080 -47. ,509 -99, ,171 1.00 36. ,08 B N

ATOM 12023 CA GLN B 157 40. 979 -46. ,615 -98. ,437 1.00 34. 90 B c

ATOM 12025 CB GLN B 157 40 168 -45. ,775 -97. ,448 1.00 35. 63 B c

ATOM 12028 CG GLN B 157 38. 941 -45. ,075 -98. ,050 1.00 35. 50 B c

ATOM 12031 CD GLN B 157 39. 305 -44. ,060 -99. ,118 1.00 38. 58 B c

ATOM 12032 OEl GLN B 157 40 058 -43. ,118 -98. ,868 1.00 40. ,61 B 0

ATOM 12033 NE2 GLN B 157 38 761 -44. ,243- -100. .314 1.00 36. ,91 B N

ATOM 12036 C GLN B 157 42 045 -47. ,417 -97. ,675 1.00 34. ,47 B c

ATOM 12037 0 GLN B 157 41 819 -48. 572 -97. ,325 1.00 33. ,08 B 0

ATOM 12039 N HIS B 158 43 201 -46. 794 -97. ,429 1.00 36. ,49 B N

ATOM 12040 CA HIS B 158 44 249 -47. ,359 -96. ,562 1.00 32. ,94 B c cyno fD_Fab

ATOM 12042 CB HIS B 158 45. 387 -47. 963 -97. 397 1. 00 37. 16 B C

ATOM 12045 CG HIS B 158 46. ,402 -46. 968 -97. 876 1. 00 40. 13 B C

ATOM 12046 NDl HIS B 158 46. 132 -46. 037 -98. 859 1. 00 43. 82 B N

ATOM 12048 CEl HIS B 158 47. 216 -45. 317 -99. 092 1. 00 45. ,85 B C

ATOM 12050 NE2 HIS B 158 48. ,181 -45. 748 -98. 298 1. 00 46. ,63 B N

ATOM 12052 CD2 HIS B 158 47. ,701 -46. 786 -97. 535 1. 00 41. ,53 B C

ATOM 12054 C HIS B 158 44. ,810 -46. 313 -95. 593 1. 00 30. ,83 B C

ATOM 12055 O HIS B 158 44. ,766 -45. 113 -95. 864 1. 00 30. 21 B 0

ATOM 12057 N VAL B 159 45. 315 -46. 775 -94. 451 1. 00 28. 83 B N

ATOM 12058 CA VAL B 159 46. 049 -45. 909 -93. 528 1. 00 26. 54 B C

ATOM 12060 CB VAL B 159 45. 093 -45. 257 -92. 522 1. 00 26. 57 B C

ATOM 12062 CGI VAL B 159 44. 635 -46. 274 -91. 487 1. 00 27. 69 B c

ATOM 12066 CG2 VAL B 159 45. ,746 -44. 038 -91. 881 1. 00 24. ,34 B c

ATOM 12070 C VAL B 159 47. ,180 -46. 679 -92. 830 1. 00 26. 07 B c

ATOM 12071 O VAL B 159 47. ,078 -47. 891 -92. 628 1. 00 28. ,36 B 0

ATOM 12073 N LEU B 160 48. 283 -45. 986 -92. 536 1. 00 24. 54 B N

ATOM 12074 CA LEU B 160 49. 342 -46. 517 -91. 679 1. 00 24. 67 B C

ATOM 12076 CB LEU B 160 50. 710 -45. 956 -92. 071 1. 00 27. 75 B C

ATOM 12079 CG LEU B 160 51. 447 -46. 636 -93. 221 1. 00 27. 59 B c

ATOM 12081 CDl LEU B 160 51. 907 -48. 043 -92. 822 1. 00 25. 42 B c

ATOM 12085 CD 2 LEU B 160 50. ,567 -46. 679 -94. 470 1. 00 33. ,94 B c

ATOM 12089 C LEU B 160 49. 038 -46. 158 -90. 219 1. 00 21. ,89 B c

ATOM 12090 O LEU B 160 48. 829 -44. 997 -89. 906 1. 00 26. ,59 B 0

ATOM 12092 N LEU B 161 49. 008 -47. 162 -89. 346 1. 00 23. 53 B N

ATOM 12093 CA LEU B 161 48. 791 -46. 973 -87. 911 1. 00 25. 23 B c

ATOM 12095 CB LEU B 161 47. 552 -47. 743 -87. 450 1. 00 23. 78 B c

ATOM 12098 CG LEU B 161 46. 246 -47. 365 -88. 125 1. 00 24. 72 B c

ATOM 12100 CDl LEU B 161 45. 036 -47. 866 -87. 322 1. 00 26. 57 B c

ATOM 12104 CD2 LEU B 161 46. 208 -45. 877 -88. 273 1. 00 23. 48 B c

ATOM 12108 C LEU B 161 49. ,991 -47. 504 -87. 155 1. 00 22. ,81 B c

ATOM 12109 O LEU B 161 50. 573 -48. 487 -87. 566 1. 00 25. ,80 B 0

ATOM 12111 N PRO B 162 50. 374 -46. 848 -86. 050 1. 00 22. ,63 B N

ATOM 12112 CA PRO B 162 51. 381 -47. 438 -85. 186 1. 00 20. 52 B c

ATOM 12114 CB PRO B 162 51.980 -46. 229 -84. 490 1. 00 22. ,63 B c

ATOM 12117 CG PRO B 162 50. 854 -45. 248 -84. 426 1. 00 22. ,79 B c

ATOM 12120 CD PRO B 162 49. 945 -45. 523 -85. 574 1. 00 22. 15 B c

ATOM 12123 C PRO B 162 50. 758 -48. 403 -84. 183 1. 00 16. 88 B c

ATOM 12124 O PRO B 162 49. ,707 -48. 113 -83. 622 1. 00 19. ,29 B 0

ATOM 12125 N VAL B 163 51. ,393 -49. 551 -83. 975 1. 00 16. ,91 B N

ATOM 12126 CA VAL B 163 50. ,907 -50. 488 -82. 974 1. 00 19. 29 B c

ATOM 12128 CB VAL B 163 51. 605 -51.841 -83. 073 1. 00 18. ,42 B c

ATOM 12130 CGI VAL B 163 51. 273 -52. 731 -81.885 1. 00 18. ,20 B c

ATOM 12134 CG2 VAL B 163 51. 232 -52. 528 -84. 391 1. 00 24. ,14 B c

ATOM 12138 C VAL B 163 51.076 -49. 868 -81. 572 1. 00 16. ,32 B c

ATOM 12139 O VAL B 163 52. 063 -49. 218 -81. 278 1. 00 18. ,15 B 0

ATOM 12141 N LEU B 164 50. 073 -50. 066 -80. 740 1. 00 18. ,44 B N

ATOM 12142 CA LEU B 164 50. ,048 -49. 563 -79. ,374 1. 00 18. ,92 B c

ATOM 12144 CB LEU B 164 48. ,727 -48. 852 -79. ,113 1. 00 19. ,12 B c

ATOM 12147 CG LEU B 164 48. ,601 -48. 201 -77. ,735 1. 00 21. ,31 B c

ATOM 12149 CDl LEU B 164 49. ,470 -46. 942 -77. ,734 1. 00 20. ,79 B c

ATOM 12153 CD2 LEU B 164 47. ,154 -47. 885 -77. 389 1. 00 21. 95 B c

ATOM 12157 C LEU B 164 50. ,177 -50. 763 -78. 448 1. 00 20. ,38 B c

ATOM 12158 O LEU B 164 49. 498 -51. 770 -78. 633 1. 00 25. ,37 B 0

ATOM 12160 N ASP B 165 51. 050 -50. 659 -77. 451 1. 00 21.20 B N

ATOM 12161 CA ASP B 165 51. ,314 -51. 786 -76. ,558 1. 00 17. ,79 B c

ATOM 12163 CB ASP B 165 52. ,502 -51. 489 -75. ,631 1. 00 17. ,93 B c

ATOM 12166 CG ASP B 165 52. 165 -50. 507 -74. ,533 1. 00 23. ,72 B c

ATOM 12167 ODl ASP B 165 52. 180 -49. 270 -74. ,802 1. 00 21. ,53 B 0

ATOM 12168 OD2 ASP B 165 51. 911 -50. 980 -73. ,397 1. 00 26. ,78 B 0

ATOM 12169 C ASP B 165 50. 077 -52. 186 -75. ,742 1. 00 17. ,72 B c

ATOM 12170 O ASP B 165 49. 190 -51. 360 -75. ,488 1. 00 23. ,00 B 0

ATOM 12172 N ARG B 166 50. 077 -53. 427 -75. ,273 1. 00 18. ,47 B N

ATOM 12173 CA ARG B 166 48. 905 -54. 035 -74. 649 1. 00 21. ,81 B c

ATOM 12175 CB ARG B 166 49. ,093 -55. ,552 -74. ,539 1. 00 23. ,30 B c

ATOM 12178 CG ARG B 166 47. ,814 -56. ,307 -74. ,170 1. 00 21.17 B c

ATOM 12181 CD ARG B 166 47. ,975 -57. 833 -74. ,337 1. 00 19. .88 B c

ATOM 12184 NE ARG B 166 48. ,142 -58. 193 -75. ,738 1. 00 20. ,21 B N

ATOM 12186 CZ ARG B 166 49. 283 -58. 588 -76. ,293 1. 00 18. ,27 B c cyno fD_Fab

ATOM 12187 NHl ARG B 166 50. ,391 -58. ,711 -75. ,564 1.00 15. ,42 B N

ATOM 12190 NH2 ARG B 166 49. ,315 -58. ,873 -77. ,592 1.00 22. 32 B N

ATOM 12193 C ARG B 166 48. 599 -53. ,469 -73. ,278 1.00 23. ,19 B C

ATOM 12194 O ARG B 166 47. ,424 -53. ,413 -72. ,882 1.00 21. ,62 B 0

ATOM 12196 N ALA B 167 49. 635 -53. ,049 -72. ,554 1.00 24. ,76 B N

ATOM 12197 CA ALA B 167 49. 430 -52. ,494 -71. 204 1.00 23. ,05 B C

ATOM 12199 CB ALA B 167 50. ,733 -52. ,511 -70. ,403 1.00 20. ,45 B C

ATOM 12203 C ALA B 167 48. ,809 -51. ,098 -71.255 1.00 17. .95 B c

ATOM 12204 O ALA B 167 47. ,945 -50. ,778 -70. ,442 1.00 22. ,75 B 0

ATOM 12206 N THR B 168 49. ,235 -50. ,271 -72. ,212 1.00 22. ,33 B N

ATOM 12207 CA THR B 168 48. 580 -48. ,977 -72. ,463 1.00 21. ,21 B c

ATOM 12209 CB THR B 168 49. 291 -48. ,134 -73. ,567 1.00 20. ,43 B c

ATOM 12211 OGl THR B 168 50. 653 -47. ,940 -73. ,206 1.00 19. ,10 B 0

ATOM 12213 CG2 THR B 168 48. 618 -46. ,758 -73. ,743 1.00 21. ,56 B c

ATOM 12217 C THR B 168 47. 156 -49. ,235 -72. 888 1.00 24. ,35 B c

ATOM 12218 O THR B 168 46. 228 -48. ,652 -72. 346 1.00 23. ,26 B 0

ATOM 12220 N CYS B 169 46. 988 -50. ,133 -73. 858 1.00 28. ,46 B N

ATOM 12221 CA CYS B 169 45. 666 -50. ,477 -74. ,337 1.00 24. ,45 B c

ATOM 12223 CB CYS B 169 45. 731 -51. ,501 -75. ,456 1.00 26. ,91 B c

ATOM 12226 SG CYS B 169 44. 380 -51.286 -76. ,564 1.00 32. ,16 B s

ATOM 12228 C CYS B 169 44. 735 -50. ,985 -73. 245 1.00 18. ,16 B c

ATOM 12229 O CYS B 169 43. 534 -50. ,754 -73. ,300 1.00 27. ,91 B 0

ATOM 12231 N ASN B 170 45. 287 -51. ,656 -72. ,245 1.00 24. ,91 B N

ATOM 12232 CA ASN B 170 44. 491 -52. ,114 -71. ,100 1.00 23. ,60 B c

ATOM 12234 CB ASN B 170 45. 022 -53. ,458 -70. 602 1.00 22. ,63 B c

ATOM 12237 CG ASN B 170 44. 463 -54. ,601 -71.377 1.00 21. ,06 B c

ATOM 12238 ODl ASN B 170 43. 301 -54. ,565 -71. 770 1.00 21. ,33 B 0

ATOM 12239 ND2 ASN B 170 45. 287 -55. ,618 -71.639 1.00 18. ,34 B N

ATOM 12242 C ASN B 170 44. 327 -51.167 -69. ,923 1.00 25. ,41 B c

ATOM 12243 O ASN B 170 43. 759 -51. ,558 -68. 902 1.00 27. ,31 B 0

ATOM 12245 N ARG B 171 44. 775 -49. 917 -70. 040 1.00 27. ,23 B N

ATOM 12246 CA ARG B 171 44. 409 -48. 938 -69. 014 1.00 24. ,14 B C

ATOM 12248 CB ARG B 171 45. 077 -47. 602 -69. 243 1.00 25. 06 B C

ATOM 12251 CG ARG B 171 46. 561 -47. 644 -69. 196 1.00 26. ,07 B C

ATOM 12254 CD ARG B 171 47. 132 -46. 326 -68. ,647 1.00 33. 56 B C

ATOM 12257 NE ARG B 171 48. 183 -45. 876 -69. 544 1.00 38. ,34 B N

ATOM 12259 CZ ARG B 171 48. 044 -44. 923 -70. 451 1.00 38. ,14 B c

ATOM 12260 NHl ARG B 171 49. 065 -44. ,604 -71. 227 1.00 39. ,48 B N

ATOM 12263 NH2 ARG B 171 46. 910 -44. ,268 -70. 555 1.00 38. ,60 B N

ATOM 12266 C ARG B 171 42. 908 -48. .711 -68. ,995 1.00 22. ,38 B C

ATOM 12267 O ARG B 171 42. 233 -48. ,847 -70. ,027 1.00 18. ,23 B 0

ATOM 12269 N ARG B 172 42. 386 -48. ,323 -67. 829 1.00 17. ,09 B N

ATOM 12270 CA ARG B 172 40. 950 -48. ,174 -67. 652 1.00 16. ,72 B C

ATOM 12272 CB ARG B 172 40. 620 -47. ,768 -66. ,186 1.00 13. ,48 B c

ATOM 12275 CG ARG B 172 41. 042 -46. ,385 -65. ,795 1.00 15. ,41 B c

ATOM 12278 CD ARG B 172 40. 744 -46. ,151 -64. ,309 1.00 22. ,79 B c

ATOM 12281 NE ARG B 172 41. 772 -46. ,781 -63. ,537 1.00 18. ,11 B N

ATOM 12283 CZ ARG B 172 41. 808 -46. 893 -62. ,220 1.00 21. ,10 B c

ATOM 12284 NHl ARG B 172 40. 811 -46. ,488 -61. ,457 1.00 23. ,33 B N

ATOM 12287 NH2 ARG B 172 42. 855 -47. ,485 -61. ,676 1.00 18. .99 B N

ATOM 12290 C ARG B 172 40. 326 -47. ,160 -68. ,601 1.00 21.22 B C

ATOM 12291 O ARG B 172 39. 203 -47. ,346 -69. ,045 1.00 31. ,84 B 0

ATOM 12293 N THR B 173 41. 039 -46. ,065 -68. ,865 1.00 27. ,38 B N

ATOM 12294 CA THR B 173 40. ,655 -45. ,062 -69. ,865 1.00 25. ,19 B C

ATOM 12296 CB THR B 173 41. 852 -44. ,099 -70. ,131 1.00 25. ,98 B C

ATOM 12298 OGl THR B 173 42. 487 -43. ,778 -68. ,887 1.00 21.76 B 0

ATOM 12300 CG2 THR B 173 41. 415 -42. ,811 -70. ,859 1.00 23. ,23 B C

ATOM 12304 C THR B 173 40. 338 -45. ,726 -71.197 1.00 28. ,05 B c

ATOM 12305 O THR B 173 39. 479 -45. ,268 -71. ,961 1.00 32. ,99 B 0

ATOM 12307 N HIS B 174 41. 077 -46. ,785 -71.480 1.00 24. ,13 B N

ATOM 12308 CA HIS B 174 41. ,041 -47. ,454 -72. ,782 1.00 22, .58 B c

ATOM 12310 CB HIS B 174 42. ,477 -47. ,697 -73. ,221 1.00 19, .66 B c

ATOM 12313 CG HIS B 174 43. 280 -46. ,437 -73. ,315 1.00 21, .51 B c

ATOM 12314 NDl HIS B 174 44. ,624 -46. ,379 -73. ,023 1.00 25, ,60 B N

ATOM 12316 CEl HIS B 174 45. ,056 -45. ,137 -73. ,184 1.00 27. ,46 B c

ATOM 12318 NE2 HIS B 174 44. ,036 -44. ,386 -73. ,560 1.00 28. .22 B N

ATOM 12320 CD2 HIS B 174 42. 914 -45. ,174 -73. ,647 1.00 25. ,46 B c

ATOM 12322 C HIS B 174 40. 170 -48. ,726 -72. ,767 1.00 20, ,04 B c cyno fD_Fab

ATOM 12323 O HIS B 174 38. .981 -48. 626 -72. ,511 1.00 31. ,31 B 0

ATOM 12325 N HIS B 175 40. .736 -49. 904 -73. ,024 1.00 25. ,30 B N

ATOM 12326 CA HIS B 175 39. ,938 -51. 140 -73. ,070 1.00 22. ,04 B C

ATOM 12328 CB HIS B 175 40. ,278 -51. 949 -74. ,300 1.00 22. ,74 B C

ATOM 12331 CG HIS B 175 40. ,013 -51. 212 -75. ,570 1.00 21. ,64 B C

ATOM 12332 NDl HIS B 175 38. ,822 -50. 568 -75. ,813 1.00 17. ,46 B N

ATOM 12334 CEl HIS B 175 38. ,872 -49. 995 -76. ,999 1.00 23. ,38 B C

ATOM 12336 NE2 HIS B 175 40. ,056 -50. 238 -77. ,534 1.00 25. ,28 B N

ATOM 12338 CD2 HIS B 175 40. ,790 -50. 998 -76. 659 1.00 23. ,73 B C

ATOM 12340 C HIS B 175 40.025 -51. 989 -71.816 1.00 24. 97 B C

ATOM 12341 O HIS B 175 39. ,580 -53. 145 -71. ,824 1.00 20. ,13 B 0

ATOM 12343 N ASP B 176 40. ,622 -51. 411 -70. ,763 1.00 26. ,50 B N

ATOM 12344 CA ASP B 176 40. ,388 -51. 789 -69. ,363 1.00 23. ,45 B C

ATOM 12346 CB ASP B 176 39. ,004 -51. 262 -68. ,952 1.00 25. 86 B c

ATOM 12349 CG ASP B 176 38. ,836 -51. 121 -67. ,440 1.00 25. ,83 B c

ATOM 12350 OOl ASP B 176 39. ,826 -51. 257 -66. ,687 1.00 23. ,55 B 0

ATOM 12351 OD2 ASP B 176 37. ,714 -50. 820 -67. ,002 1.00 27. ,35 B 0

ATOM 12352 C ASP B 176 40. ,492 -53. 293 -69. ,057 1.00 29. 03 B c

ATOM 12353 O ASP B 176 39. 699 -53. 813 -68. ,283 1.00 27. ,39 B 0

ATOM 12355 N GLY B 177 41. ,460 -53. 988 -69. ,661 1.00 24. ,47 B N

ATOM 12356 CA GLY B 177 41.682 -55. 410 -69. ,374 1.00 26. ,75 B c

ATOM 12359 C GLY B 177 41. ,184 -56. 381 -70. ,429 1.00 30. ,00 B c

ATOM 12360 O GLY B 177 41. ,541 -57. 547 -70. ,419 1.00 31. ,57 B 0

ATOM 12362 N ALA B 178 40. ,360 -55. 896 -71.347 1.00 32. ,65 B N

ATOM 12363 CA ALA B 178 39. ,756 -56. 736 -72. ,363 1.00 28. ,75 B c

ATOM 12365 CB ALA B 178 38. ,616 -55. 991 -73. 037 1.00 28. ,68 B c

ATOM 12369 C ALA B 178 40. ,744 -57. 238 -73. ,409 1.00 25. ,30 B c

ATOM 12370 0 ALA B 178 40. ,424 -58. 135 -74. ,170 1.00 29. ,04 B 0

ATOM 12372 N ILE B 179 41.944 -56. 671 -73. ,438 1.00 25. ,89 B N

ATOM 12373 CA ILE B 179 42. ,917 -56. 989 -74. ,474 1.00 25. ,51 B c

ATOM 12375 CB ILE B 179 43. ,754 -55. 758 -74. ,874 1.00 24. ,88 B c

ATOM 12377 CGI ILE B 179 42. 851 -54. 565 -75. ,194 1.00 16. ,41 B c

ATOM 12380 CDl ILE B 179 41. 709 -54. 860 -76. ,195 1.00 19. ,54 B c

ATOM 12384 CG2 ILE B 179 44.628 -56. 103 -76. ,034 1.00 13. ,47 B c

ATOM 12388 C ILE B 179 43. 853 -58. 090 -74. 020 1.00 23. ,13 B c

ATOM 12389 0 ILE B 179 44. 753 -57. 876 -73. ,203 1.00 25. ,10 B 0

ATOM 12391 N THR B 180 43. ,648 -59. 273 -74. ,583 1.00 22. ,84 B N

ATOM 12392 CA THR B 180 44. ,400 -60. 448 -74. ,193 1.00 25. ,44 B c

ATOM 12394 CB THR B 180 43. ,504 -61. 712 -74. ,271 1.00 27. ,04 B c

ATOM 12396 OGl THR B 180 43. ,033 -61. 878 -75. ,603 1.00 24. ,83 B 0

ATOM 12398 CG2 THR B 180 42. ,294 -61. 572 -73, ,344 1.00 25. ,63 B c

ATOM 12402 C THR B 180 45. ,618 -60. 588 -75. ,108 1.00 24. ,43 B c

ATOM 12403 0 THR B 180 45. ,783 -59. 820 -76. ,054 1.00 22, ,80 B 0

ATOM 12405 N GLN B 181 46. ,453 -61. 584 -74. ,830 1.00 27. ,19 B N

ATOM 12406 CA GLN B 181 47. 626 -61. 878 -75. ,655 1.00 27. ,49 B c

ATOM 12408 CB GLN B 181 48. ,516 -62. 904 -74. ,972 1.00 29. ,96 B c

ATOM 12411 CG GLN B 181 49. ,174 -62. ,420 -73. ,716 1.00 32. ,90 B c

ATOM 12414 CD GLN B 181 49. ,737 -63. 566 -72. ,900 1.00 36. .57 B c

ATOM 12415 OEl GLN B 181 48. ,989 -64. 415 -72. ,387 1.00 39. .84 B 0

ATOM 12416 NE2 GLN B 181 51. ,058 -63. 608 -72. ,784 1.00 36. ,06 B N

ATOM 12419 C GLN B 181 47. ,271 -62. 401 -77. ,037 1.00 24.29 B C

ATOM 12420 0 GLN B 181 48. ,156 -62. 538 -77. ,886 1.00 18. ,67 B 0

ATOM 12422 N ARG B 182 45. ,985 -62. 671 -77. ,264 1.00 25. ,40 B N

ATOM 12423 CA ARG B 182 45. ,494 -63. 100 -78. ,567 1.00 30. ,47 B c

ATOM 12425 CB ARG B 182 44. ,379 -64. ,141 -78. .387 1.00 35. .17 B c

ATOM 12428 CG ARG B 182 44. ,669 -65. ,173 -77. .273 1.00 40, ,82 B c

ATOM 12431 CD ARG B 182 43. ,646 -66. 313 -77. ,211 1.00 41. .00 B c

ATOM 12434 NE ARG B 182 43. ,829 -67. ,276 -78. ,294 1.00 43. .02 B N

ATOM 12436 CZ ARG B 182 43. ,155 -68. ,422 -78. ,415 1.00 46. ,17 B c

ATOM 12437 NHl ARG B 182 42. ,226 -68. ,767 -77. ,526 1.00 47. .48 B N

ATOM 12440 NH2 ARG B 182 43. ,409 -69. 234 -79. ,443 1.00 44. .75 B N

ATOM 12443 C ARG B 182 45. ,008 -61.886 -79. ,376 1.00 25. ,77 B C

ATOM 12444 0 ARG B 182 44. ,527 -62. ,024 -80, ,503 1.00 23. .74 B 0

ATOM 12446 N MET B 183 45, ,162 -60. ,697 -78, .795 1.00 26, .60 B N

ATOM 12447 CA MET B 183 44. ,725 -59. ,449 -79, .395 1.00 23, ,37 B C

ATOM 12449 CB MET B 183 43. ,602 -58. ,856 -78, ,560 1.00 23, .04 B c

ATOM 12452 CG MET B 183 42. ,279 -59. ,552 -78. ,753 1.00 28, .87 B c

ATOM 12455 SD MET B 183 41.228 -59. ,441 -77. ,311 1.00 27, ,27 B s cyno fD_Fab

ATOM 12456 CE MET B 183 40. 440 -57. ,869 -77. 602 1.00 26. 41 B C

ATOM 12460 C MET B 183 45. 879 -58. ,460 -79. 423 1.00 23. 18 B C

ATOM 12461 O MET B 183 46. .832 -58. 628 -78. 684 1.00 18. 39 B 0

ATOM 12463 N MET B 184 45. ,766 -57. 436 -80. 274 1.00 22. 51 B N

ATOM 12464 CA MET B 184 46. ,714 -56. ,328 -80. 343 1.00 19. 16 B C

ATOM 12466 CB MET B 184 47. 739 -56. ,542 -81. 481 1.00 12. 38 B C

ATOM 12469 CG MET B 184 47. ,161 -56. 685 -82. 833 1.00 15. 65 B C

ATOM 12472 SD MET B 184 48. ,408 -57. ,002 -84. 091 1.00 20. 88 B s

ATOM 12473 CE MET B 184 49. ,372 -55. ,487 -83. 928 1.00 24. 15 B C

ATOM 12477 C MET B 184 45. ,938 -54. 997 -80. 487 1.00 26. 16 B c

ATOM 12478 O MET B 184 44. 707 -54. 989 -80. 598 1.00 27. 39 B 0

ATOM 12480 N CYS B 185 46. 656 -53. 873 -80. 426 1.00 31. 68 B N

ATOM 12481 CA CYS B 185 46. ,046 -52. 532 -80. 504 1.00 24. 79 B c

ATOM 12483 CB CYS B 185 45. ,985 -51. ,881 -79. 118 1.00 33. 38 B c

ATOM 12486 SG CYS B 185 44. ,751 -52. ,627 -78. 038 1.00 31. 13 B s

ATOM 12488 C CYS B 185 46. ,819 -51. ,642 -81. 452 1.00 25. 25 B c

ATOM 12489 O CYS B 185 48. ,001 -51. ,875 -81. 700 1.00 23. 30 B 0

ATOM 12491 N ALA B 186 46. 140 -50. 635 -81. 996 1.00 25. 26 B N

ATOM 12492 CA ALA B 186 46. ,785 -49. 577 -82. 764 1.00 25. 79 B c

ATOM 12494 CB ALA B 186 46. 569 -49. 770 -84. 229 1.00 19. 31 B c

ATOM 12498 C ALA B 186 46. ,226 -48. ,238 -82. 308 1.00 27. 30 B c

ATOM 12499 O ALA B 186 45. ,150 -48. ,173 -81. 724 1.00 23. 06 B 0

ATOM 12501 N GLU B 187 46. ,962 -47. ,164 -82. 564 1.00 32. 54 B N

ATOM 12502 CA GLU B 187 46. 491 -45. ,822 -82. 177 1.00 34. 16 B c

ATOM 12504 CB GLU B 187 47. ,606 -44. ,785 -82. 353 1.00 39. 81 B c

ATOM 12507 CG GLU B 187 48. 503 -44. 657 -81. 108 1.00 41.73 B c

ATOM 12510 CD GLU B 187 49. 840 -43. 993 -81. 396 1.00 41. 27 B c

ATOM 12511 OEl GLU B 187 49. 857 -42. 937 -82. 072 1.00 48. 18 B 0

ATOM 12512 OE2 GLU B 187 50. 870 -44. 534 -80. 950 1.00 35. 43 B 0

ATOM 12513 C GLU B 187 45. ,226 -45. ,420 -82. 936 1.00 31. 85 B c

ATOM 12514 O GLU B 187 45. 046 -45. ,808 -84. 087 1.00 23. 94 B 0

ATOM 12516 N SER B 188 44. 339 -44. ,672 -82. 269 1.00 29. 13 B N

ATOM 12517 CA SER B 188 43. 047 -44. ,290 -82. 854 1.00 29. 24 B c

ATOM 12519 CB SER B 188 41. 938 -44. ,853 -81. 992 1.00 29. 49 B C

ATOM 12522 OG SER B 188 42. 022 -44. 288 -80. 710 1.00 23. 72 B 0

ATOM 12524 C SER B 188 42. 797 -42. ,779 -83. 035 1.00 30. 41 B c

ATOM 12525 O SER B 188 41. 722 -42. 398 -83. 487 1.00 35. 94 B 0

ATOM 12527 N ASN B 189 43. ,756 -41. ,923 -82. 688 1.00 33. 96 B N

ATOM 12528 CA ASN B 189 43. ,598 -40. ,471 -82. ,861 1.00 36. 25 B c

ATOM 12530 CB ASN B 189 44. ,382 -39. ,732 -81. 769 1.00 41. 76 B c

ATOM 12533 CG ASN B 189 43. ,822 -38. 329 -81. 464 1.00 42. 76 B c

ATOM 12534 ODl ASN B 189 42. ,711 -37. 959 -81.874 1.00 44. 05 B 0

ATOM 12535 ND2 ASN B 189 44. 596 -37. ,554 -80. 717 1.00 48. 51 B N

ATOM 12538 C ASN B 189 44. ,081 -40. ,005 -84. 235 1.00 37. 18 B c

ATOM 12539 O ASN B 189 45. 198 -40. ,317 -84. 630 1.00 28. 62 B 0

ATOM 12541 N ARG B 190 43. 258 -39. ,251 -84. 960 1.00 43. 34 B N

ATOM 12542 CA ARG B 190 43. ,601 -38. ,801 -86. ,331 1.00 47. 86 B c

ATOM 12544 CB ARG B 190 45. ,051 -38. ,265 -86. ,452 1.00 56. 87 B c

ATOM 12547 CG ARG B 190 45. ,493 -37. ,165 -85. 490 1.00 64. 92 B c

ATOM 12550 CD ARG B 190 44. ,799 -35. ,827 -85. 777 1.00 68. 56 B c

ATOM 12553 NE ARG B 190 43. ,820 -35. ,469 -84. 748 1.00 69. 84 B N

ATOM 12555 CZ ARG B 190 42. ,927 -34. ,484 -84. 854 1.00 70. 25 B c

ATOM 12556 NHl ARG B 190 42. ,855 -33. ,730 -85. 952 1.00 71. 33 B N

ATOM 12559 NH2 ARG B 190 42. 098 -34. ,248 -83. 843 1.00 71. 75 B N

ATOM 12562 C ARG B 190 43. ,479 -39. ,907 -87. 383 1.00 49. 60 B C

ATOM 12563 0 ARG B 190 43. ,286 -39. ,615 -88. ,562 1.00 52. ,36 B 0

ATOM 12565 N ARG B 191 43. ,577 -41. ,160 -86. ,943 1.00 46. ,89 B N

ATOM 12566 CA ARG B 191 43. ,977 -42. ,284 -87. ,778 1.00 41. 72 B C

ATOM 12568 CB ARG B 191 45. ,508 -42. ,376 -87. ,720 1.00 46. ,85 B c

ATOM 12571 CG ARG B 191 46. ,241 -42. ,410 -89. 043 1.00 50. 50 B c

ATOM 12574 CD ARG B 191 46. ,045 -41. ,137 -89. 868 1.00 55. 03 B c

ATOM 12577 NE ARG B 191 46. ,781 -39. ,965 -89. 370 1.00 58. 53 B N

ATOM 12579 CZ ARG B 191 47. ,947 -39. ,512 -89. ,852 1.00 60. 20 B c

ATOM 12580 NHl ARG B 191 48. ,566 -40. ,131 -90. ,859 1.00 58. ,75 B N

ATOM 12583 NH2 ARG B 191 48. ,505 -38. ,422 -89. ,318 1.00 58. 28 B N

ATOM 12586 C ARG B 191 43. ,340 -43. ,554 -87. ,170 1.00 38. ,78 B c

ATOM 12587 0 ARG B 191 43. 591 -43, ,866 -86. ,003 1.00 38. 01 B 0

ATOM 12589 N ASP B 192 42. ,513 -44. ,281 -87. ,919 1.00 31. 46 B N ATOM 12590 CA ASP B 192 41, , -87. ,306 1.00 32. ,51 B C

ATOM 12592 CB ASP B 192 40. . -86. ,348 1.00 21. ,27 B C

ATOM 12595 CG ASP B 192 40. . -85. 173 1.00 25. ,16 B C

ATOM 12596 ODl ASP B 192 40. , -85. 048 1.00 23. ,93 B 0

ATOM 12597 OD2 ASP B 192 39. , -84. 338 1.00 22. ,08 B 0

ATOM 12598 C ASP B 192 41. , -88. 343 1.00 29. ,77 B c

ATOM 12599 O ASP B 192 41. ,008 -45. ,935 -89. 514 1.00 28. ,89 B 0

ATOM 12601 N SER B 193 40. ,598 -47. 429 -87. 878 1.00 31. ,41 B N

ATOM 12602 CA SER B 193 39. ,627 -48. 230 -88. 608 1.00 30. ,60 B c

ATOM 12604 CB SER B 193 39. .980 -49. ,731 -88. ,546 1.00 24. ,61 B c

ATOM 12607 OG SER B 193 40. ,219 -50. ,205 -87. ,232 1.00 23. ,64 B 0

ATOM 12609 C SER B 193 38. ,225 -47. 957 -88. ,054 1.00 28. ,28 B c

ATOM 12610 O SER B 193 38. ,060 -47. ,636 -86. 889 1.00 26. ,62 B 0

ATOM 12612 N CYS B 194 37. ,211 -48. 059 -88. ,897 1.00 33. ,44 B N

ATOM 12613 CA CYS B 194 35. .860 -47. 676 -88. 491 1.00 34. ,54 B c

ATOM 12615 CB CYS B 194 35. ,483 -46. 333 -89. 128 1.00 42. ,51 B c

ATOM 12618 SG CYS B 194 36. ,648 -44. 948 -88. 878 1.00 43. ,06 B s

ATOM 12620 C CYS B 194 34. ,835 -48. 731 -88. 889 1.00 34. ,89 B c

ATOM 12621 O CYS B 194 35. ,167 -49. 707 -89. 584 1.00 31. ,54 B 0

ATOM 12623 N LYS B 195 33. ,590 -48. 527 -88. 450 1.00 35. ,30 B N

ATOM 12624 CA LYS B 195 32. ,478 -49. 382 -88. 852 1.00 36. ,48 B c

ATOM 12626 CB LYS B 195 31.143 -48. ,702 -88. ,548 1.00 43. ,84 B c

ATOM 12629 CG LYS B 195 29. ,908 -49. ,586 -88. 764 1.00 45. ,58 B c

ATOM 12632 CD LYS B 195 28. ,614 -48. 822 -88. ,415 1.00 48. ,20 B c

ATOM 12635 CE LYS B 195 27. ,345 -49. 649 -88. 697 1.00 49. ,81 B c

ATOM 12638 NZ LYS B 195 26. ,137 -48. 785 -88. 920 1.00 50. 73 B N

ATOM 12642 C LYS B 195 32. ,601 -49. 707 -90. 341 1.00 36. ,37 B c

ATOM 12643 0 LYS B 195 32. ,814 -48. 813 -91. 167 1.00 38. 14 B 0

ATOM 12645 N GLY B 196 32. ,527 -50. 996 -90. 669 1.00 34. ,77 B N

ATOM 12646 CA GLY B 196 32. ,722 -51.474 -92. 044 1.00 31.07 B C

ATOM 12649 C GLY B 196 34. 132 -51. 928 -92. 374 1.00 28. ,95 B c

ATOM 12650 0 GLY B 196 34. ,339 -52. 607 -93. 387 1.00 28. ,36 B 0

ATOM 12652 N ASP B 197 35. ,112 -51. 563 -91. 541 1.00 28. ,85 B N

ATOM 12653 CA ASP B 197 36. ,484 -52. 030 -91. 727 1.00 30. ,11 B c

ATOM 12655 CB ASP B 197 37. ,505 -50. 986 -91. 263 1.00 32. ,11 B c

ATOM 12658 CG ASP B 197 37. ,480 -49. ,716 -92. 106 1.00 32. ,64 B c

ATOM 12659 ODl ASP B 197 37. ,596 -49. 815 -93. 347 1.00 25. ,98 B 0

ATOM 12660 002 ASP B 197 37. ,354 -48. 620 -91.514 1.00 28. ,14 B 0

ATOM 12661 C ASP B 197 36. ,720 -53. 343 -90. 986 1.00 27. ,89 B c

ATOM 12662 0 ASP B 197 37. ,725 -54. 005 -91.230 1.00 23. ,25 B 0

ATOM 12664 N SER B 198 35. ,801 -53. ,705 -90. 086 1.00 27. ,74 B N

ATOM 12665 CA SER B 198 35. ,899 -54. ,941 -89. 303 1.00 28. ,33 B c

ATOM 12667 CB SER B 198 34. ,637 -55. 164 -88. 473 1.00 32. ,77 B c

ATOM 12670 OG SER B 198 34. ,074 -53. 940 -88. 067 1.00 35. ,65 B 0

ATOM 12672 C SER B 198 36. ,066 -56. 136 -90. 217 1.00 34. ,26 B c

ATOM 12673 0 SER B 198 35. ,490 -56. ,189 -91. ,301 1.00 36. ,53 B 0

ATOM 12675 N GLY B 199 36. ,860 -57. ,097 -89. ,773 1.00 30. ,10 B N

ATOM 12676 CA GLY B 199 37. ,126 -58. ,276 -90. ,551 1.00 25. ,02 B C

ATOM 12679 C GLY B 199 38. ,278 -58. ,042 -91. ,501 1.00 26. ,51 B c

ATOM 12680 0 GLY B 199 38. ,868 -58. ,993 -92. Oil 1.00 25. ,55 B 0

ATOM 12682 N GLY B 200 38. ,609 -56. ,779 -91. 744 1.00 21.40 B N

ATOM 12683 CA GLY B 200 39. ,683 -56. ,459 -92. ,668 1.00 19. ,67 B c

ATOM 12686 C GLY B 200 41. ,069 -56. ,686 -92. 088 1.00 18. ,61 B C

ATOM 12687 0 GLY B 200 41. ,238 -56. ,963 -90. ,905 1.00 24. ,41 B 0

ATOM 12689 N PRO B 201 42. 085 -56. ,557 -92. 924 1.00 19. ,41 B N

ATOM 12690 CA PRO B 201 43. ,452 -56. ,891 -92. 550 1.00 20. ,21 B c

ATOM 12692 CB PRO B 201 44. ,087 -57. ,196 -93. ,905 1.00 14. ,63 B c

ATOM 12695 CG PRO B 201 43. ,389 -56. ,287 -94. ,840 1.00 16, .23 B c

ATOM 12698 CD PRO B 201 41. .986 -56. ,123 -94. ,328 1.00 18, .49 B c

ATOM 12701 C PRO B 201 44. ,281 -55. ,802 -91. ,865 1.00 19, .96 B c

ATOM 12702 0 PRO B 201 44. ,224 -54. 626 -92. ,261 1.00 25. .78 B 0

ATOM 12703 N LEU B 202 45. ,067 -56. ,209 -90. ,866 1.00 21. .43 B N

ATOM 12704 CA LEU B 202 46. ,146 -55. ,384 -90. 322 1.00 21, ,51 B c

ATOM 12706 CB LEU B 202 46. ,092 -55. ,315 -88. ,799 1.00 22. .40 B C

ATOM 12709 CG LEU B 202 47. ,095 -54. ,366 -88. ,132 1.00 26. ,16 B C

ATOM 12711 CDl LEU B 202 46. ,977 -52. ,967 -88. ,727 1.00 30. ,54 B c

ATOM 12715 CD 2 LEU B 202 46. ,884 -54. ,299 -86. ,618 1.00 22. ,05 B c

ATOM 12719 C LEU B 202 47. ,428 -56. ,025 -90. 780 1.00 19. ,80 B c cyno fD..Fab

ATOM 12720 O LEU B 202 47. 732 -57. 166 -90. 424 1.00 23. 87 B 0

ATOM 12722 N VAL B 203 48. 176 -55. 304 -91.597 1.00 21. 60 B N

ATOM 12723 CA VAL B 203 49. ,307 -55. 889 -92. 299 1.00 23. 05 B C

ATOM 12725 CB VAL B 203 49. ,119 -55. 799 -93. 817 1.00 21. 19 B C

ATOM 12727 CGl VAL B 203 50. ,339 -56. ,388 -94. 554 1.00 19. 96 B c

ATOM 12731 CG2 VAL B 203 47. ,849 -56. ,540 -94. 229 1.00 18. 47 B c

ATOM 12735 C VAL B 203 50. ,577 -55. ,182 -91. 869 1.00 27. 66 B c

ATOM 12736 O VAL B 203 50. ,609 -53. ,958 -91.755 1.00 30. 26 B 0

ATOM 12738 N CYS B 204 51. ,618 -55. 961 -91. 613 1.00 33. 39 B N

ATOM 12739 CA CYS B 204 52. ,807 -55. 431 -90. 984 1.00 32. 24 B c

ATOM 12741 CB CYS B 204 52. ,648 -55. 525 -89. 467 1.00 37. 62 B c

ATOM 12744 SG CYS B 204 53. 062 -53. 960 -88. 775 1.00 48. 12 B s

ATOM 12746 C CYS B 204 54. 071 -56. 124 -91. 457 1.00 34. 61 B c

ATOM 12747 O CYS B 204 54. ,273 -57. 308 -91. 209 1.00 40. 52 B 0

ATOM 12749 N GLY B 205 54. ,911 -55. ,378 -92. 169 1.00 33. 44 B N

ATOM 12750 CA GLY B 205 56. ,124 -55. 926 -92. 762 1.00 31. 85 B c

ATOM 12753 C GLY B 205 55. 893 -56. ,808 -93. 989 1.00 30. 55 B c

ATOM 12754 O GLY B 205 56. ,761 -57. 600 -94. 349 1.00 31. 65 B 0

ATOM 12756 N GLY B 206 54. ,727 -56. 664 -94. 619 1.00 29. 64 B N

ATOM 12757 CA GLY B 206 54. 300 -57. 523 -95. 719 1.00 28. 20 B c

ATOM 12760 C GLY B 206 53. 526 -58. 774 -95. 314 1.00 27. 32 B c

ATOM 12761 O GLY B 206 53. 221 -59. 617 -96. 171 1.00 29. 21 B 0

ATOM 12763 N VAL B 207 53. 195 -58. 886 -94. 027 1.00 21. 74 B N

ATOM 12764 CA VAL B 207 52. ,625 -60. 095 -93. 452 1.00 23. 06 B c

ATOM 12766 CB VAL B 207 53. ,608 -60. ,717 -92. 416 1.00 28. 00 B c

ATOM 12768 CGl VAL B 207 52. 990 -61. 924 -91. 712 1.00 27. 18 B c

ATOM 12772 CG2 VAL B 207 54. 913 -61. 099 -93. 073 1.00 26. 98 B c

ATOM 12776 C VAL B 207 51. 339 -59. 742 -92. 729 1.00 24. 52 B c

ATOM 12777 O VAL B 207 51.279 -58. 723 -92. 050 1.00 27. 17 B 0

ATOM 12779 N LEU B 208 50. 307 -60. 574 -92. 855 1.00 21. 49 B N

ATOM 12780 CA LEU B 208 49. 075 -60. 344 -92. 110 1.00 19. 75 B C

ATOM 12782 CB LEU B 208 47. 915 -61.183 -92. 660 1.00 19. 46 B C

ATOM 12785 CG LEU B 208 46. 549 -60. 993 -91. 984 1.00 21.09 B C

ATOM 12787 CDl LEU B 208 45. 990 -59. 594 -92. 231 1.00 20. 90 B c

ATOM 12791 CD2 LEU B 208 45. 578 -62. 058 -92. 451 1.00 24. 00 B c

ATOM 12795 C LEU B 208 49. 306 -60. 672 -90. 639 1.00 16. 80 B c

ATOM 12796 O LEU B 208 49. ,732 -61. 779 -90. 311 1.00 17. 28 B 0

ATOM 12798 N GLU B 209 49. 007 -59. ,716 -89. 759 1.00 19. 57 B N

ATOM 12799 CA GLU B 209 49. 160 -59. 901 -88. 307 1.00 18. 30 B c

ATOM 12801 CB GLU B 209 50. 145 -58. 858 -87. 737 1.00 20. 45 B c

ATOM 12804 CG GLU B 209 51. 604 -59. 002 -88. 212 1.00 22. 24 B c

ATOM 12807 CD GLU B 209 52. 406 -60. 092 -87. 487 1.00 22. 68 B c

ATOM 12808 OEl GLU B 209 51.894 -60. 705 -86. 527 1.00 20. 36 B 0

ATOM 12809 OE2 GLU B 209 53. ,570 -60. ,330 -87. 882 1.00 23. ,81 B 0

ATOM 12810 C GLU B 209 47. ,840 -59. ,808 -87. 544 1.00 19. 66 B c

ATOM 12811 0 GLU B 209 47. ,707 -60. ,371 -86. 467 1.00 21. ,43 B 0

ATOM 12813 N GLY B 210 46. 875 -59. ,076 -88. 080 1.00 20. 19 B N

ATOM 12814 CA GLY B 210 45. 633 -58. ,844 -87. 367 1.00 22. ,73 B c

ATOM 12817 C GLY B 210 44. ,441 -58. ,773 -88. 285 1.00 24. ,35 B c

ATOM 12818 0 GLY B 210 44. ,579 -58. 555 -89. 492 1.00 29. 49 B 0

ATOM 12820 N VAL B 211 43. 280 -59. ,001 -87. 690 1.00 23. 47 B N

ATOM 12821 CA VAL B 211 41. 994 -58. ,839 -88. 334 1.00 27. 41 B c

ATOM 12823 CB VAL B 211 41. ,218 -60. ,196 -88. 437 1.00 26. 91 B c

ATOM 12825 CGl VAL B 211 39. ,808 -59. ,985 -88. ,945 1.00 22. ,67 B c

ATOM 12829 CG2 VAL B 211 41. ,947 -61.137 -89. 339 1.00 24. ,74 B c

ATOM 12833 C VAL B 211 41. ,218 -57. ,847 -87. 489 1.00 26. ,97 B c

ATOM 12834 0 VAL B 211 41. ,057 -58. ,037 -86. 274 1.00 29. ,50 B 0

ATOM 12836 N VAL B 212 40. ,768 -56. ,772 -88. 126 1.00 25. ,07 B N

ATOM 12837 CA VAL B 212 40. ,040 -55. ,722 -87. 429 1.00 30. ,10 B c

ATOM 12839 CB VAL B 212 39. 562 -54. ,624 -88. 410 1.00 26. ,29 B c

ATOM 12841 CGl VAL B 212 38. ,905 -53. ,504 -87. 667 1.00 22. ,55 B c

ATOM 12845 CG2 VAL B 212 40. ,721 -54. ,100 -89. 261 1.00 23. ,72 B c

ATOM 12849 C VAL B 212 38. ,838 -56. ,354 -86. 732 1.00 32. 68 B c

ATOM 12850 0 VAL B 212 38. ,007 -56. ,977 -87. 392 1.00 32. ,55 B 0

ATOM 12852 N TH B 213 38. ,751 -56. ,205 -85. ,410 1.00 38. 68 B N

ATOM 12853 CA THR B 213 37. 755 -56. 931 -84. ,617 1.00 43. ,21 B c

ATOM 12855 CB THR B 213 38. 284 -57. ,420 -83. 232 1.00 44. ,47 B c

ATOM 12857 OGl THR B 213 37. 737 -56. ,618 -82. ,178 1.00 51. ,49 B 0 cyno fD_Fab

ATOM 12859 CG2 THR B 213 39. 776 -57. .391 -83. 161 1.00 45. 20 B C

ATOM 12863 C THR B 213 36. 547 -56. .066 -84. 348 1.00 48. 06 B C

ATOM 12864 O THR B 213 36. 689 -54. ,904 -83. 949 1.00 48. 06 B 0

ATOM 12866 N SER B 214 35. 370 -56. .680 -84. 514 1.00 52. 98 B N

ATOM 12867 CA SER B 214 34. 056 -56. ,028 -84. 388 1.00 53. 87 B C

ATOM 12869 CB SER B 214 32. 943 -57. ,038 -84. 683 1.00 54. 46 B C

ATOM 12872 OG SER B 214 33. 121 -57. ,650 -85. 952 1.00 56. 90 B 0

ATOM 12874 C SER B 214 33. 773 -55. ,386 -83. 024 1.00 56. 74 B C

ATOM 12875 O SER B 214 34. 412 -55. ,709 -82. 012 1.00 55. 19 B 0

ATOM 12877 N GLY B 215 32. 795 -54. ,479 -83. 020 1.00 57. 46 B N

ATOM 12878 CA GLY B 215 32. 375 -53. .799 -81. 801 1.00 58. 22 B c

ATOM 12881 C GLY B 215 31. 651 -52. ,491 -82. 057 1.00 59. 41 B c

ATOM 12882 O GLY B 215 31. 572 -52. 017 -83. 196 1.00 58. 04 B 0

ATOM 12884 N SER B 216 31. 139 -51. ,908 -80. 973 1.00 60. 54 B N

ATOM 12885 CA SER B 216 30. 436 -50. ,626 -81. 010 1.00 58. 52 B C

ATOM 12887 CB SER B 216 29. 458 -50. ,531 -79. 829 1.00 62. 23 B C

ATOM 12890 OG SER B 216 28. 595 -51. ,655 -79. 770 1.00 63. 51 B 0

ATOM 12892 C SER B 216 31. 401 -49. ,440 -80. 941 1.00 58. 82 B c

ATOM 12893 O SER B 216 30. 979 -48. ,307 -80. 669 1.00 59. 52 B 0

ATOM 12895 N ARG B 217 32. 687 -49. ,687 -81. 190 1.00 52. 13 B N

ATOM 12896 CA ARG B 217 33. 693 -48. ,661 -80. 985 1.00 49. 02 B c

ATOM 12898 CB ARG B 217 35. 099 -49. 260 -81. 009 1.00 47. 01 B c

ATOM 12901 CG ARG B 217 36. 190 -48. ,329 -80. 506 1.00 44. 75 B c

ATOM 12904 CD ARG B 217 37. 541 -49. ,000 -80. 614 1.00 43. ,24 B c

ATOM 12907 NE ARG B 217 37. 833 -49. ,308 -82. 006 1.00 40. 55 B N

ATOM 12909 CZ ARG B 217 38. 405 -48. ,474 -82. 866 1.00 40. 85 B c

ATOM 12910 NHl ARG B 217 38. 802 -47. ,263 -82. 488 1.00 41.60 B N

ATOM 12913 NH2 ARG B 217 38. 596 -48. ,863 -84. 111 1.00 41. 87 B N

ATOM 12916 C ARG B 217 33. 542 -47. ,574 -82. 044 1.00 46. 79 B c

ATOM 12917 0 ARG B 217 33. 588 -47. ,845 -83. 253 1.00 43. 16 B 0

ATOM 12919 N VAL B 218 33. 333 -46. ,349 -81. 565 1.00 45. 08 B N

ATOM 12920 CA VAL B 218 33. 277 -45. ,168 -82. 420 1.00 44. 05 B c

ATOM 12922 CB VAL B 218 32. 370 -44. ,007 -81. 831 1.00 42. 47 B C

ATOM 12924 CGI VAL B 218 31. 669 -44. ,430 -80. 534 1.00 45. 34 B c

ATOM 12928 CG2 VAL B 218 33. 145 -42. ,684 -81.665 1.00 37. 20 B c

ATOM 12932 C VAL B 218 34. 723 -44. ,760 -82. 688 1.00 42. 28 B c

ATOM 12933 0 VAL B 218 35. 502 -44. ,535 -81.763 1.00 47. 05 B 0

ATOM 12935 N CYS B 219 35. 078 -44. ,718 -83. 964 1.00 42. 66 B N

ATOM 12936 CA CYS B 219 36. 449 -44. ,539 -84. 365 1.00 40. 61 B c

ATOM 12938 CB CYS B 219 36. 652 -45. ,026 -85. 811 1.00 45. 01 B c

ATOM 12941 SG CYS B 219 35. 958 -44. ,035 -87. 177 1.00 44. 56 B S

ATOM 12943 C CYS B 219 36. 896 -43. ,095 -84. 184 1.00 38. 26 B c

ATOM 12944 0 CYS B 219 36. 081 -42. ,216 -83. 920 1.00 35. 49 B 0

ATOM 12946 N GLY B 220 38. 207 -42. ,875 -84. ,290 1.00 38. 66 B N

ATOM 12947 CA GLY B 220 38. 796 -41. ,545 -84. 193 1.00 36. 27 B c

ATOM 12950 C GLY B 220 39. 009 -40. ,990 -82. 800 1.00 34. 67 B c

ATOM 12951 0 GLY B 220 39. 574 -39. ,908 -82. ,666 1.00 31. ,81 B 0

ATOM 12953 N ASN B 221 38. 561 -41. ,722 -81. 775 1.00 34. 53 B N

ATOM 12954 CA ASN B 221 38. 732 -41. ,330 -80. ,361 1.00 31. ,34 B C

ATOM 12956 CB ASN B 221 37. 532 -41. ,804 -79. 526 1.00 30. 32 B C

ATOM 12959 CG ASN B 221 37. 630 -41. ,368 -78. ,079 1.00 33. 10 B c

ATOM 12960 ODl ASN B 221 38. 596 -40. ,687 -77. 695 1.00 29. 33 B 0

ATOM 12961 ND2 ASN B 221 36. 632 -41. .747 -77. ,260 1.00 30. ,55 B N

ATOM 12964 C ASN B 221 40. 008 -41.892 -79. ,708 1.00 25. ,77 B c

ATOM 12965 0 ASN B 221 40. 168 -43. .115 -79. ,556 1.00 31. ,37 B 0

ATOM 12967 N ARG B 222 40. 877 -40. ,998 -79. ,260 1.00 21. ,52 B N

ATOM 12968 CA ARG B 222 42. 143 -41. ,397 -78. ,662 1.00 31. 80 B C

ATOM 12970 CB ARG B 222 42. 990 -40. ,174 -78. ,280 1.00 39. ,15 B C

ATOM 12973 CG ARG B 222 42. 325 -39. ,248 -77. ,270 1.00 42. ,38 B C

ATOM 12976 CD ARG B 222 43. 326 -38. ,407 -76. ,524 1.00 43. ,71 B C

ATOM 12979 NE ARG B 222 42. 674 -37. ,524 -75. ,548 1.00 46. ,61 B N

ATOM 12981 CZ ARG B 222 42. 638 -37. .716 -74. ,222 1.00 48. ,44 B C

ATOM 12982 NHl ARG B 222 43. 201 -38. .782 -73. ,650 1.00 48. ,01 B N

ATOM 12985 NH2 ARG B 222 42. 026 -36. .820 -73. ,455 1.00 48. ,27 B N

ATOM 12988 C ARG B 222 41. 975 -42. .294 -77. ,441 1.00 29. ,03 B C

ATOM 12989 0 ARG B 222 42. 868 -43. .078 -77. ,147 1.00 26. ,64 B 0

ATOM 12991 N LYS B 223 40. 839 -42. .176 -76. 742 1.00 19. ,67 B N

ATOM 12992 CA LYS B 223 40. 588 -42. ,968 -75. 549 1.00 23. ,73 B C cyno fD_Fab

ATOM 12994 CB LYS B 223 39. 543 -42. 280 -74. 663 1.00 26. 03 B C

ATOM 12997 CG LYS B 223 40. Oil -40. 935 -74. 111 1.00 24. ,43 B C

ATOM 13000 CD LYS B 223 38. 967 -40. 338 -73. 182 1.00 26. 56 B C

ATOM 13003 CE LYS B 223 39. 451 -39. ,070 -72. 541 1.00 26. ,53 B c

ATOM 13006 NZ LYS B 223 38. 410 -38. 586 -71.534 1.00 26. ,62 B N

ATOM 13010 C LYS B 223 40. 138 -44. 383 -75. 830 1.00 23. ,91 B c

ATOM 13011 0 LYS B 223 39. 960 -45. ,137 -74. 897 1.00 25. ,38 B 0

ATOM 13013 N LYS B 224 39. 928 -44. ,739 -77. 100 1.00 25. ,57 B N

ATOM 13014 CA LYS B 224 39. 579 -46. 107 -77. 475 1.00 23. ,84 B C

ATOM 13016 CB LYS B 224 38. 086 -46. 197 -77. 726 1.00 27. 62 B C

ATOM 13019 CG LYS B 224 37. 227 -45. 953 -76. 487 1.00 22. ,32 B c

ATOM 13022 CD LYS B 224 37. 413 -47. 064 -75. 495 1.00 28. ,01 B c

ATOM 13025 CE LYS B 224 36. 370 -47. ,038 -74. 389 1.00 30. ,00 B c

ATOM 13028 NZ LYS B 224 36. 718 -45. 985 -73. 460 1.00 30. ,16 B N

ATOM 13032 C LYS B 224 40. 333 -46. ,526 -78. 728 1.00 26. ,59 B c

ATOM 13033 0 LYS B 224 39. 846 -46. ,292 -79. 821 1.00 26. ,94 B 0

ATOM 13035 N PRO B 225 41.534 -47. 125 -78. 568 1.00 21. ,64 B N

ATOM 13036 CA PRO B 225 42. 341 -47. 586 -79. 692 1.00 24. ,08 B c

ATOM 13038 CB PRO B 225 43. 583 -48. 179 -79. 008 1.00 24. ,21 B c

ATOM 13041 CG PRO B 225 43. 609 -47. 510 -77. 623 1.00 21. ,28 B c

ATOM 13044 CD PRO B 225 42. 198 -47. ,388 -77. 279 1.00 19. 22 B c

ATOM 13047 C PRO B 225 41. 652 -48. ,654 -80. 537 1.00 24. ,95 B c

ATOM 13048 0 PRO B 225 40. 725 -49. ,311 -80. 064 1.00 19. ,94 B 0

ATOM 13049 N GLY B 226 42. 114 -48. 815 -81. 779 1.00 25. 87 B N

ATOM 13050 CA GLY B 226 41. 706 -49. 936 -82. 601 1.00 23. 30 B c

ATOM 13053 C GLY B 226 42. 083 -51. 256 -81.954 1.00 24. 37 B c

ATOM 13054 0 GLY B 226 43. 182 -51. 391 -81. 399 1.00 20. 66 B 0

ATOM 13056 N ILE B 227 41. 149 -52. 209 -81. 989 1.00 26. 50 B N

ATOM 13057 CA ILE B 227 41. 370 -53. 579 -81. 511 1.00 26. ,12 B c

ATOM 13059 CB ILE B 227 40. 251 -54. ,075 -80. 599 1.00 23. ,20 B c

ATOM 13061 CGI ILE B 227 40. 032 -53. ,100 -79. 451 1.00 27. ,37 B c

ATOM 13064 CDl ILE B 227 38. 962 -53. ,533 -78. 473 1.00 25. ,99 B c

ATOM 13068 CG2 ILE B 227 40. 620 -55. ,455 -80. 016 1.00 24. 03 B c

ATOM 13072 C ILE B 227 41. 476 -54. 525 -82. 705 1.00 22. ,93 B c

ATOM 13073 0 ILE B 227 40. 673 -54. ,453 -83. 600 1.00 24. ,13 B 0

ATOM 13075 N TYR B 228 42. 495 -55. 383 -82. 702 1.00 24. 67 B N

ATOM 13076 CA TYR B 228 42. 776 -56. 303 -83. 800 1.00 27. 23 B c

ATOM 13078 CB TYR B 228 43. 970 -55. ,808 -84. 632 1.00 30. ,05 B c

ATOM 13081 CG TYR B 228 43. 768 -54. ,405 -85. ,142 1.00 31. ,24 B c

ATOM 13082 CDl TYR B 228 43. 292 -54. ,167 -86. 431 1.00 34. ,27 B c

ATOM 13084 CEl TYR B 228 43. 077 -52. ,867 -86. 893 1.00 31. ,75 B c

ATOM 13086 CZ TYR B 228 43. 329 -51. ,788 -86. 052 1.00 32. ,54 B c

ATOM 13087 OH TYR B 228 43. 123 -50. ,480 -86. 484 1.00 34. ,49 B 0

ATOM 13089 CE2 TYR B 228 43. 792 -52. ,007 -84. 770 1.00 32. ,60 B c

ATOM 13091 CD2 TYR B 228 44. 017 -53. ,309 -84. 326 1.00 32. ,70 B c

ATOM 13093 C TYR B 228 43. 036 -57. ,679 -83. 186 1.00 29. ,09 B c

ATOM 13094 0 TYR B 228 43. 648 -57. ,774 -82. ,126 1.00 32. ,03 B 0

ATOM 13096 N THR B 229 42. 518 -58. ,732 -83. ,820 1.00 33. ,05 B N

ATOM 13097 CA THR B 229 42. 749 -60. ,102 -83. 359 1.00 28. ,74 B c

ATOM 13099 CB THR B 229 41.557 -61. ,033 -83. 664 1.00 27. ,50 B c

ATOM 13101 OGl THR B 229 40. 393 -60. ,526 -82. 999 1.00 35. ,85 B 0

ATOM 13103 CG2 THR B 229 41.840 -62. ,435 -83. ,160 1.00 27. ,56 B c

ATOM 13107 C THR B 229 43. 984 -60. ,599 -84. ,045 1.00 25. ,39 B c

ATOM 13108 0 THR B 229 44. 106 -60. ,457 -85. 259 1.00 27. ,69 B 0

ATOM 13110 N ARG B 230 44. 900 -61. ,188 -83. ,273 1.00 25. .80 B N

ATOM 13111 CA ARG B 230 46. 200 -61. ,611 -83. ,801 1.00 22. ,04 B c

ATOM 13113 CB ARG B 230 47. 243 -61. ,674 -82. ,687 1.00 16. .56 B c

ATOM 13116 CG ARG B 230 47. 309 -60. ,448 -81. ,785 1.00 21.78 B c

ATOM 13119 CD ARG B 230 48. 451 -60. ,508 -80. ,760 1.00 20. ,47 B c

ATOM 13122 NE ARG B 230 49. 634 -61. ,154 -81.339 1.00 20. ,11 B N

ATOM 13124 CZ ARG B 230 50. 078 -62. ,374 -81. ,025 1.00 19. ,36 B c

ATOM 13125 NHl ARG B 230 49. 464 -63. ,094 -80. ,088 1.00 15. ,22 B N

ATOM 13128 NH2 ARG B 230 51.166 -62. ,864 -81. ,634 1.00 17. .45 B N

ATOM 13131 C ARG B 230 46. 100 -62. .971 -84. ,496 1.00 23. ,77 B c

ATOM 13132 0 ARG B 230 45. 770 -63. ,954 -83. ,861 1.00 23, .45 B 0

ATOM 13134 N VAL B 231 46. 396 -63. ,020 -85. ,799 1.00 24. .64 B N

ATOM 13135 CA VAL B 231 46. 173 -64. ,227 -86. ,590 1.00 24. ,06 B C

ATOM 13137 CB VAL B 231 46. 328 -63. ,989 -88. ,137 1.00 19. ,98 B c cyno fD_Fab

ATOM 13139 CGI VAL B 231 45. ,390 -62. 868 -88. 619 1. 00 15. .87 B C

ATOM 13143 CG2 VAL B 231 47. ,761 -63. ,676 -88. 517 1. 00 20. ,74 B C

ATOM 13147 C VAL B 231 47. ,100 -65. ,345 -86. 106 1. 00 31. ,59 B C

ATOM 13148 O VAL B 231 46. ,669 -66. ,492 -85. 989 1. 00 30. 56 B 0

ATOM 13150 N ALA B 232 48. ,348 -64. ,988 -85. 778 1. 00 34. 03 B N

ATOM 13151 CA ALA B 232 49. ,348 -65. ,922 -85. 239 1. 00 29. ,56 B C

ATOM 13153 CB ALA B 232 50. ,632 -65. ,180 -84. 896 1. 00 28. ,02 B c

ATOM 13157 C ALA B 232 48. 862 -66. ,711 -84. 025 1. 00 27. ,13 B c

ATOM 13158 O ALA B 232 49. ,232 -67. ,863 -83. 848 1. 00 30, ,33 B 0

ATOM 13160 N SER B 233 48. 003 -66. ,104 -83. 224 1. 00 29. ,52 B N

ATOM 13161 CA SER B 233 47. ,456 -66. ,758 -82. 041 1. 00 32. ,05 B c

ATOM 13163 CB SER B 233 46. ,819 -65. ,705 -81. 138 1. 00 32. ,47 B c

ATOM 13166 OG ASER B 233 46. ,469 -66. ,253 -79. 886 0. 70 33. 28 B 0

ATOM 13167 OG BSER B 233 46. ,476 -66. ,253 -79. 881 0. 30 32. ,87 B 0

ATOM 13170 C SER B 233 46. ,418 -67. ,841 -82. 379 1. 00 36. ,21 B c

ATOM 13171 O SER B 233 46. ,042 -68. ,639 -81. 511 1. 00 32. ,89 B 0

ATOM 13173 N TYR B 234 45. ,946 -67. ,840 -83. 628 1. 00 36. ,81 B N

ATOM 13174 CA TYR B 234 44. ,969 -68. ,809 -84. ,119 1. 00 33. ,43 B c

ATOM 13176 CB TYR B 234 43. ,687 -68. ,069 -84. 538 1. 00 27. ,07 B c

ATOM 13179 CG TYR B 234 43. ,034 -67. ,410 -83. 355 1. 00 27. ,36 B c

ATOM 13180 CDl TYR B 234 42. ,121 -68. ,102 -82. 570 1. 00 24. ,29 B c

ATOM 13182 CEl TYR B 234 41. ,547 -67. ,516 -81.470 1. 00 27. ,04 B c

ATOM 13184 CZ TYR B 234 41. 885 -66. ,214 -81. 131 1. 00 27. ,17 B c

ATOM 13185 OH TYR B 234 41. ,313 -65. ,636 -80. 024 1. 00 24. ,92 B 0

ATOM 13187 CE2 TYR B 234 42. ,802 -65. ,513 -81. ,889 1. 00 23. ,22 B c

ATOM 13189 CD2 TYR B 234 43. ,363 -66. ,105 -82. ,990 1. 00 24, ,96 B c

ATOM 13191 C TYR B 234 45. 537 -69. ,629 -85. 275 1. 00 32. ,65 B c

ATOM 13192 O TYR B 234 44. ,787 -70. 129 -86. 101 1. 00 32. ,40 B 0

ATOM 13194 N ALA B 235 46. 859 -69. 788 -85. 313 1. 00 33. ,23 B N

ATOM 13195 CA ALA B 235 47. 530 -70. 362 -86. 468 1. 00 36. ,14 B c

ATOM 13197 CB ALA B 235 49. 038 -70. ,188 -86. 358 1. 00 35. ,92 B c

ATOM 13201 C ALA B 235 47. 180 -71. ,829 -86. 685 1. 00 40. ,42 B c

ATOM 13202 O ALA B 235 47. 099 -72. ,268 -87. 827 1. 00 37. ,42 B 0

ATOM 13204 N ALA B 236 46. ,969 -72. ,574 -85. 596 1. 00 44. ,20 B N

ATOM 13205 CA ALA B 236 46. ,585 -73. ,992 -85. ,682 1. 00 44. ,92 B c

ATOM 13207 CB ALA B 236 46. ,840 -74. ,698 -84. ,354 1. 00 45, ,62 B c

ATOM 13211 C ALA B 236 45. ,118 -74. ,160 -86. 111 1. 00 46. ,95 B c

ATOM 13212 O ALA B 236 44. ,770 -75. ,138 -86. 793 1. 00 44. ,28 B 0

ATOM 13214 N TRP B 237 44. ,275 -73. ,206 -85. ,711 1. 00 45, ,41 B N

ATOM 13215 CA TRP B 237 42. 873 -73. ,171 -86. 131 1. 00 44. ,74 B c

ATOM 13217 CB TRP B 237 42. 097 -72. ,176 -85. 284 1. 00 46. ,44 B c

ATOM 13220 CG TRP B 237 40. 679 -72. ,060 -85. 689 1. 00 47. ,73 B c

ATOM 13221 CDl TRP B 237 39. ,682 -72. ,956 -85. .439 1. 00 48. ,34 B c

ATOM 13223 NEl TRP B 237 38. ,496 -72. ,503 -85. ,968 1. 00 48. ,60 B N

ATOM 13225 CE2 TRP B 237 38. ,712 -71. ,296 -86. ,581 1. 00 48. ,23 B c

ATOM 13226 CD2 TRP B 237 40. ,079 -70. ,983 -86. ,424 1. 00 49. ,07 B c

ATOM 13227 CE3 TRP B 237 40. ,564 -69. ,781 -86. ,961 1. ,00 49. ,18 B c

ATOM 13229 CZ3 TRP B 237 39. ,675 -68. ,940 -87. ,628 1. 00 47. ,94 B c

ATOM 13231 CH2 TRP B 237 38. ,320 -69. ,280 -87. ,765 1. 00 47, ,55 B c

ATOM 13233 CZ2 TRP B 237 37. ,820 -70. ,449 -87. ,253 1. 00 48. ,82 B c

ATOM 13235 C TRP B 237 42. ,717 -72. ,809 -87. ,611 1. 00 43. ,89 B c

ATOM 13236 O TRP B 237 41, ,906 -73. ,412 -88, ,318 1. ,00 43, .80 B 0

ATOM 13238 N ILE B 238 43. ,483 -71, ,818 -88. ,066 1. ,00 41, ,60 B N

ATOM 13239 CA ILE B 238 43. ,484 -71. ,413 -89. ,472 1. ,00 41. .42 B c

ATOM 13241 CB ILE B 238 44. ,378 -70. ,159 -89. ,731 1. ,00 40. ,10 B c

ATOM 13243 CGI ILE B 238 43. ,760 -68. ,917 -89. ,084 1. 00 37. ,96 B c

ATOM 13246 CDl ILE B 238 44. ,693 -67. ,720 -89. ,048 1. 00 37. ,39 B c

ATOM 13250 CG2 ILE B 238 44. ,584 -69. ,923 -91. ,243 1. ,00 38. ,65 B c

ATOM 13254 C ILE B 238 43. ,947 -72. ,562 -90. ,366 1. 00 41, ,67 B c

ATOM 13255 O ILE B 238 43. ,383 -72. ,769 -91. ,440 1. 00 43. ,03 B 0

ATOM 13257 N ASP B 239 44. ,967 -73, .299 -89. ,922 1. ,00 40, ,13 B N

ATOM 13258 CA ASP B 239 45. ,498 -74, .433 -90, ,684 1. ,00 38, ,88 B C

ATOM 13260 CB ASP B 239 46. ,751 -75, .012 -89, ,999 1. ,00 41. .07 B C

ATOM 13263 CG ASP B 239 47. ,972 -74, ,107 -90. ,106 1. 00 39, ,85 B C

ATOM 13264 ODl ASP B 239 48. ,036 -73. ,261 -91, ,020 1. 00 40, .45 B 0

ATOM 13265 OD2 ASP B 239 48. ,881 -74. ,257 -89. ,263 1. 00 34, .60 B 0

ATOM 13266 C ASP B 239 44. .478 -75. ,568 -90. ,860 1. ,00 35. ,34 B C

ATOM 13267 O ASP B 239 44. ,451 -76, ,224 -91. ,919 1. 00 29. ,37 B 0 cyno fD_Fab

ATOM 13269 N SER B 240 43. ,676 -75. 804 -89. ,814 1.00 31.43 B N

ATOM 13270 CA SER B 240 42. ,705 -76. 898 -89. 789 1.00 35. ,28 B C

ATOM 13272 CB SER B 240 42. ,243 -77. ,205 -88. ,362 1.00 32. ,54 B C

ATOM 13275 OG ASER B 240 41. ,543 -76. 119 -87. 793 0.60 34. 01 B 0

ATOM 13276 OG 1 3SER B 240 41. ,545 -76. 114 -87. ,795 0.40 33. ,91 B 0

ATOM 13279 C SER B 240 41. ,502 -76. 639 -90. 690 1.00 39. ,25 B c

ATOM 13280 O SER B 240 40. ,983 -77. 568 -91. 311 1.00 41. ,26 B 0

ATOM 13282 N VAL B 241 41. ,066 -75. 383 -90. 761 1.00 42. ,50 B N

ATOM 13283 CA VAL B 241 39. ,999 -74. ,996 -91. ,678 1.00 39. ,20 B c

ATOM 13285 CB VAL B 241 39. ,357 -73. ,676 -91. ,240 1.00 38. 67 B c

ATOM 13287 CGl VAL B 241 38. ,297 -73. 229 -92. 236 1.00 41.01 B c

ATOM 13291 CG2 VAL B 241 38. ,739 -73. ,840 -89. ,850 1.00 37. ,15 B c

ATOM 13295 C VAL B 241 40. ,512 -74. ,973 -93. ,138 1.00 40. ,16 B c

ATOM 13296 0 VAL B 241 39. 831 -75. ,471 -94. ,030 1.00 42. ,73 B 0

ATOM 13298 N LEU B 242 41. ,725 -74. 459 -93. 369 1.00 39. ,93 B N

ATOM 13299 CA LEU B 242 42. ,328 -74. 414 -94. 729 1.00 40. ,02 B c

ATOM 13301 CB LEU B 242 43. ,447 -73. 358 -94. 810 1.00 37. ,96 B c

ATOM 13304 CG LEU B 242 43. ,039 -71.901 -95. 059 1.00 35. ,95 B c

ATOM 13306 CDl LEU B 242 42. ,081 -71. ,428 -94. ,012 1.00 33. ,01 B c

ATOM 13310 CD2 LEU B 242 44. ,268 -71. ,016 -95. ,095 1.00 37. ,74 B c

ATOM 13314 C LEU B 242 42. 891 -75. ,745 -95. 246 1.00 43. 69 B c

ATOM 13315 O LEU B 242 43. ,248 -75. ,850 -96. ,432 1.00 41.13 B 0

ATOM 13317 N ALA B 243 42. 987 -76. ,746 -94. ,371 1.00 44. ,89 B N

ATOM 13318 CA ALA B 243 43. 600 -78. ,025 -94. 725 1.00 44. ,55 B c

ATOM 13320 CB ALA B 243 43. 643 -78. 939 -93. 509 1.00 44. ,61 B c

ATOM 13324 C ALA B 243 42. ,863 -78. 708 -95. 879 1.00 45. ,79 B c

ATOM 13325 O ALA B 243 43. ,480 -79. 312 -96. 763 1.00 48. ,06 B 0

ATOM 13327 OXT ALA B 243 41. ,634 -78. 667 -95. 950 1.00 43. ,21 B 0

ATOM 13328 N ASP D 1 48. ,973 -32. ,215 -66. ,529 1.00 19. ,57 D N

ATOM 13329 CA ASP D 1 48. 225 -32. ,692 -65. 331 1.00 24. ,41 D c

ATOM 13331 CB ASP D 1 49. 025 -32. ,404 -64. 042 1.00 26. ,97 D c

ATOM 13334 CG ASP D 1 49. 111 -30. ,913 -63. ,702 1.00 32. ,13 D c

ATOM 13335 ODl ASP D 1 49. ,242 -30. ,078 -64. ,640 1.00 28. ,05 D 0

ATOM 13336 OD2 ASP D 1 49. ,041 -30. ,579 -62. 487 1.00 31. ,06 D 0

ATOM 13337 C ASP D 1 46. ,853 -32. ,036 -65. 278 1.00 21.56 D c

ATOM 13338 O ASP D 1 46. ,668 -30. 908 -65. 781 1.00 25. ,79 D 0

ATOM 13342 N ILE D 2 45. ,894 -32. 724 -64. 666 1.00 22. ,91 D N

ATOM 13343 CA ILE D 2 44. ,509 -32. 222 -64. 563 1.00 21. ,69 D c

ATOM 13345 CB ILE D 2 43. ,496 -33. 203 -65. ,207 1.00 19. ,40 D c

ATOM 13347 CGl ILE D 2 43. ,829 -33. ,417 -66. ,693 1.00 25. ,16 D c

ATOM 13350 CDl ILE D 2 42. ,831 -34. ,241 -67. ,486 1.00 25. ,49 D c

ATOM 13354 CG2 ILE D 2 42. ,041 -32. 716 -65. ,022 1.00 19. ,22 D c

ATOM 13358 C ILE D 2 44. ,166 -32. ,014 -63. ,090 1.00 26. 88 D c

ATOM 13359 O ILE D 2 44. ,398 -32. 898 -62. 261 1.00 30. ,79 D 0

ATOM 13361 N GLN D 3 43. ,620 -30. 841 -62. 771 1.00 25. ,83 D N

ATOM 13362 CA GLN D 3 43. ,249 -30. 493 -61. ,404 1.00 24. .89 D c

ATOM 13364 CB GLN D 3 43. ,170 -28. 973 -61. ,229 1.00 31. ,96 D c

ATOM 13367 CG GLN D 3 42. ,984 -28. ,463 -59. ,797 1.00 29. ,94 D c

ATOM 13370 CD GLN D 3 42. ,672 -26. ,982 -59. ,746 1.00 35. .38 D c

ATOM 13371 OEl GLN D 3 42. ,206 -26. ,393 -60. 723 1.00 47. .20 D 0

ATOM 13372 NE2 GLN D 3 42. ,916 -26. ,367 -58. 599 1.00 39. ,60 D N

ATOM 13375 C GLN D 3 41. ,897 -31.096 -61. 070 1.00 24. ,25 D c

ATOM 13376 0 GLN D 3 40. ,986 -31.154 -61.901 1.00 20. ,21 D 0

ATOM 13378 N VAL D 4 41.762 -31. ,543 -59. ,829 1.00 20. ,69 D N

ATOM 13379 CA VAL D 4 40. ,531 -32. ,103 -59. 389 1.00 20. ,45 D c

ATOM 13381 CB VAL D 4 40. ,607 -33. 631 -59. ,293 1.00 26. .93 D c

ATOM 13383 CGl VAL D 4 39. ,261 -34. ,207 -58. ,858 1.00 31.60 D c

ATOM 13387 CG2 VAL D 4 41. ,038 -34. ,213 -60. ,647 1.00 25. ,84 D c

ATOM 13391 C VAL D 4 40. ,255 -31. ,487 -58. ,045 1.00 23, .12 D c

ATOM 13392 0 VAL D 4 41. ,082 -31. ,560 -57. ,122 1.00 22, ,41 D 0

ATOM 13394 N THR D 5 39. ,088 -30. ,867 -57. ,941 1.00 24, .54 D N

ATOM 13395 CA THR D 5 38. ,617 -30. ,330 -56. ,681 1.00 20, .09 D c

ATOM 13397 CB THR D 5 38. ,138 -28. ,873 -56. ,853 1.00 22, .80 D c

ATOM 13399 OGl THR D 5 39. ,254 -28. ,080 -57. ,176 1.00 22, .15 D 0

ATOM 13401 CG2 THR D 5 37. ,526 -28. ,338 -55. ,555 1.00 21, .63 D c

ATOM 13405 C THR D 5 37. ,454 -31. ,145 -56. ,192 1.00 18, .91 D c

ATOM 13406 0 THR D 5 36. ,415 -31.199 -56. ,850 1.00 22. .90 D 0

ATOM 13408 N GLN D 6 37. ,614 -31. ,742 -55. ,014 1.00 28. .74 D N cyno fD_Fab

ATOM 13409 CA GLN D 6 36.606 -32. ,573 -54. 418 1.00 23. 73 D C

ATOM 13411 CB GLN D 6 37. 190 -33. ,910 -53. 965 1.00 24. 43 D C

ATOM 13414 CG GLN D 6 36. 124 -34. ,842 -53. 363 1.00 27. 14 D C

ATOM 13417 CD GLN D 6 36. 607 -36. ,243 -53. 121 1.00 29. 14 D C

ATOM 13418 OEl GLN D 6 37. 618 -36. ,678 -53. 685 1.00 29. 57 D 0

ATOM 13419 NE2 GLN D 6 35. 892 -36.963 -52. 272 1.00 26. ,51 D N

ATOM 13422 C GLN D 6 36. 017 -31. 886 -53. 207 1.00 25. 91 D C

ATOM 13423 O GLN D 6 36. 756 -31. 321 -52. 389 1.00 21.21 D 0

ATOM 13425 N SER D 7 34. 691 -31. 979 -53. 069 1.00 25. 02 D N

ATOM 13426 CA SER D 7 34. 006 -31. 337 -51. 944 1.00 23. 41 D C

ATOM 13428 CB SER D 7 33. 661 -29. ,874 -52. 279 1.00 26. 36 D C

ATOM 13431 OG SER D 7 33. 278 -29. 733 -53. 615 1.00 27. 44 D 0

ATOM 13433 C SER D 7 32. 760 -32. ,089 -51. 496 1.00 20. 11 D c

ATOM 13434 O SER D 7 32. 172 -32. ,827 -52. 270 1.00 17. 38 D 0

ATOM 13436 N PRO D 8 32. 362 -31.936 -50. 213 1.00 20. 95 D N

ATOM 13437 CA PRO D 8 33. 012 -31. 202 -49. 150 1.00 20. 86 D c

ATOM 13439 CB PRO D 8 31. 915 -31. ,094 -48. 088 1.00 22. 69 D c

ATOM 13442 CG PRO D 8 31. 151 -32. ,325 -48. 232 1.00 20. 93 D c

ATOM 13445 CD PRO D 8 31. 143 -32. ,611 -49. 731 1.00 18. 09 D c

ATOM 13448 C PRO D 8 34. 199 -31. ,997 -48. 598 1.00 23. ,11 D c

ATOM 13449 O PRO D 8 34. 405 -33. 155 -48. 991 1.00 28. 31 D 0

ATOM 13450 N SER D 9 34. 950 -31. ,386 -47. 683 1.00 23. ,18 D N

ATOM 13451 CA SER D 9 36. 032 -32. ,063 -46. 978 1.00 25. 81 D c

ATOM 13453 CB SER D 9 36. 928 -31. ,059 -46. 272 1.00 29. 03 D c

ATOM 13456 OG SER D 9 37. 318 -30. ,064 -47. 196 1.00 38. 54 D 0

ATOM 13458 C SER D 9 35. 487 -33. ,051 -45. 982 1.00 24. 05 D c

ATOM 13459 O SER D 9 36. 058 -34. ,107 -45. 785 1.00 18. 27 D 0

ATOM 13461 N SER D 10 34. 367 -32. ,711 -45. 355 1.00 24. 78 D N

ATOM 13462 CA SER D 10 33. 684 -33. ,657 -44. 500 1.00 22. 43 D c

ATOM 13464 CB SER D 10 34. 355 -33. ,723 -43. 112 1.00 24. 16 D c

ATOM 13467 OG SER D 10 34. 357 -32. ,461 -42. ,487 1.00 30. 49 D 0

ATOM 13469 C SER D 10 32. 187 -33. ,330 -44. 425 1.00 22. 54 D c

ATOM 13470 O SER D 10 31. 733 -32. ,216 -44. 731 1.00 20. 86 D 0

ATOM 13472 N LEU D 11 31. ,417 -34. ,348 -44. 109 1.00 22. 69 D N

ATOM 13473 CA LEU D 11 29. 981 -34. ,203 -43. 931 1.00 22. 25 D c

ATOM 13475 CB LEU D 11 29. 197 -34. ,378 -45. 240 1.00 22. 13 D c

ATOM 13478 CG LEU D 11 29. 091 -35. ,745 -45. 905 1.00 20. 33 D c

ATOM 13480 CDl LEU D 11 27. 960 -36. ,598 -45. 314 1.00 18. ,37 D c

ATOM 13484 CD2 LEU D 11 28. 928 -35. ,596 -47. 436 1.00 23. ,97 D c

ATOM 13488 C LEU D 11 29. 530 -35. ,214 -42. 922 1.00 24. ,57 D c

ATOM 13489 O LEU D 11 30. 217 -36. 222 -42. 667 1.00 25. 25 D 0

ATOM 13491 N SER D 12 28. 373 -34. ,911 -42. 351 1.00 26. ,67 D N

ATOM 13492 CA SER D 12 27. 732 -35. 727 -41. 361 1.00 26. 87 D c

ATOM 13494 CB SER D 12 27. 901 -35. ,083 -39. 991 1.00 30. ,17 D c

ATOM 13497 OG SER D 12 27. ,493 -35. ,975 -38. 995 1.00 30. 87 D 0

ATOM 13499 C SER D 12 26. 245 -35. ,813 -41. ,692 1.00 26. 02 D c

ATOM 13500 O SER D 12 25. ,575 -34. .796 -41. 839 1.00 25. ,36 D 0

ATOM 13502 N ALA D 13 25. ,727 -37. ,030 -41. 783 1.00 24. ,10 D N

ATOM 13503 CA ALA D 13 24. 323 -37. ,238 -42. 116 1.00 26. ,90 D c

ATOM 13505 CB ALA D 13 24. 176 -37. ,461 -43. 588 1.00 28. ,31 D c

ATOM 13509 C ALA D 13 23. 808 -38. ,430 -41. 346 1.00 28. 05 D c

ATOM 13510 O ALA D 13 24. 592 -39. ,235 -40. ,880 1.00 26. 76 D 0

ATOM 13512 N SER D 14 22. 490 -38. ,546 -41. 217 1.00 30. ,67 D N

ATOM 13513 CA SER D 14 21. 874 -39. ,675 -40. 529 1.00 25. ,25 D c

ATOM 13515 CB SER D 14 20. ,503 -39. ,275 -40. ,003 1.00 26. ,90 D c

ATOM 13518 OG SER D 14 20. ,585 -38. ,111 -39. ,208 1.00 33. ,41 D 0

ATOM 13520 C SER D 14 21. 726 -40. ,916 -41.424 1.00 26. ,66 D c

ATOM 13521 O SER D 14 21. ,773 -40. ,833 -42. 663 1.00 23. ,39 D 0

ATOM 13523 N VAL D 15 21. 518 -42. ,061 -40. 776 1.00 20. ,93 D N

ATOM 13524 CA VAL D 15 21.249 -43. ,328 -41. ,457 1.00 26. ,09 D c

ATOM 13526 CB VAL D 15 21. 135 -44. ,512 -40. ,430 1.00 25. ,46 D c

ATOM 13528 CGI VAL D 15 20. 622 -45. ,811 -41. ,082 1.00 22. ,95 D c

ATOM 13532 CG2 VAL D 15 22. ,485 -44, .765 -39. .768 1.00 24. .08 D c

ATOM 13536 C VAL D 15 19. ,972 -43. ,199 -42. ,291 1.00 28. ,08 D c

ATOM 13537 O VAL D 15 18. ,915 -42. ,804 -41. ,780 1.00 29. ,11 D 0

ATOM 13539 N GLY D 16 20. ,087 -43. ,529 -43. ,575 1.00 27. ,77 D N

ATOM 13540 CA GLY D 16 19. 010 -43. ,361 -44. ,532 1.00 26.28 D c

ATOM 13543 C GLY D 16 19. 047 -42. ,075 -45. ,344 1.00 26. ,03 D c cyno fD_Fab

ATOM 13544 O GLY D 16 18. 415 -42. 004 -46. 388 1.00 24. 84 D 0

ATOM 13546 N ASP D 17 19. 778 -41. 054 -44. ,895 1.00 27. ,51 D N

ATOM 13547 CA ASP D 17 19. 919 -39. 818 -45. ,685 1.00 26. ,21 D C

ATOM 13549 CB ASP D 17 20. 653 -38. 715 -44. ,903 1.00 25. ,90 D C

ATOM 13552 CG ASP D 17 19. 813 -38. 096 -43. ,823 1.00 27. ,62 D c

ATOM 13553 ODl ASP D 17 18. 591 -38. 364 -43. ,764 1.00 39. ,37 D 0

ATOM 13554 OD2 ASP D 17 20. 381 -37. 334 -43. ,016 1.00 29. ,26 D 0

ATOM 13555 C ASP D 17 20. 666 -40. 040 -47. Oil 1.00 26. 68 D c

ATOM 13556 O ASP D 17 21. 462 -40. 975 -47. ,147 1.00 30. 93 D 0

ATOM 13558 N ARG D 18 20. 385 -39. 163 -47. ,970 1.00 27. ,18 D N

ATOM 13559 CA ARG D 18 21. 147 -39. 054 -49. ,195 1.00 26. ,36 D c

ATOM 13561 CB ARG D 18 20. 319 -38. 510 -50. ,340 1.00 27. ,00 D c

ATOM 13564 CG ARG D 18 21.175 -38. 357 -51. ,619 1.00 30. ,93 D c

ATOM 13567 CD ARG D 18 20. 426 -37. 813 -52. ,760 1.00 34. ,70 D c

ATOM 13570 NE ARG D 18 19. 295 -38. 674 -53. ,084 1.00 44. ,15 D N

ATOM 13572 CZ ARG D 18 18. 244 -38. 290 -53. ,801 1.00 43. ,90 D C

ATOM 13573 NHl ARG D 18 18. 181 -37. 055 -54. ,301 1.00 43. ,67 D N

ATOM 13576 NH2 ARG D 18 17. 255 -39. 152 -54. ,021 1.00 39. ,28 D N

ATOM 13579 C ARG D 18 22. 348 -38. 143 -48. ,974 1.00 25. ,60 D C

ATOM 13580 0 ARG D 18 22. 212 -36. 959 -48. ,602 1.00 27. ,50 D 0

ATOM 13582 N VAL D 19 23. 516 -38. 729 -49. ,216 1.00 23. ,65 D N

ATOM 13583 CA VAL D 19 24. 813 -38. 084 -49. 111 1.00 24. ,05 D C

ATOM 13585 CB VAL D 19 25. 843 -39. 040 -48. ,431 1.00 21. ,27 D c

ATOM 13587 CGI VAL D 19 27. 280 -38. 567 -48. ,644 1.00 23. ,14 D c

ATOM 13591 CG2 VAL D 19 25. 529 -39. 218 -46. ,928 1.00 18. ,30 D c

ATOM 13595 C VAL D 19 25. 241 -37. 818 -50. ,552 1.00 21. ,67 D c

ATOM 13596 O VAL D 19 25. 174 -38. 708 -51. ,372 1.00 20. ,46 D 0

ATOM 13598 N THR D 20 25. 629 -36. 588 -50. ,864 1.00 27. ,05 D N

ATOM 13599 CA THR D 20 26. 116 -36. 252 -52. ,209 1.00 23. ,42 D c

ATOM 13601 CB THR D 20 25. 155 -35. 312 -52. ,981 1.00 25. ,07 D c

ATOM 13603 OG1 THR D 20 24. 894 -34. 150 -52. ,213 1.00 38. ,55 D 0

ATOM 13605 CG2 THR D 20 23. 850 -35. 985 -53. ,301 1.00 27. ,26 D c

ATOM 13609 C THR D 20 27. 517 -35. 636 -52. ,114 1.00 24. ,90 D c

ATOM 13610 O THR D 20 27. 796 -34. 811 -51. ,223 1.00 22. .86 D 0

ATOM 13612 N ILE D 21 28. 404 -36. 081 -53. ,005 1.00 25. ,69 D N

ATOM 13613 CA ILE D 21 29. 831 -35. 688 -53. ,013 1.00 26. .57 D c

ATOM 13615 CB ILE D 21 30. 730 -36. 853 -52. ,486 1.00 31. .11 D c

ATOM 13617 CGI ILE D 21 30. 437 -37. 123 -51. .009 1.00 30. 64 D c

ATOM 13620 CDl ILE D 21 31. 123 -38. 390 -50. ,436 1.00 29. 62 D c

ATOM 13624 CG2 ILE D 21 32. 210 -36. 548 -52. ,678 1.00 26. ,71 D c

ATOM 13628 C ILE D 21 30. 225 -35. 312 -54. ,445 1.00 22. ,51 D c

ATOM 13629 O ILE D 21 29. 790 -35. 998 -55. ,385 1.00 22. ,54 D 0

ATOM 13631 N THR D 22 31. 004 -34. 231 -54. ,646 1.00 26. ,62 D N

ATOM 13632 CA THR D 22 31. 348 -33. ,813 -56. ,040 1.00 28. ,09 D c

ATOM 13634 CB THR D 22 30. 640 -32. 432 -56. ,461 1.00 33. ,03 D c

ATOM 13636 OGl THR D 22 31. 335 -31. 306 -55. ,944 1.00 38. ,54 D 0

ATOM 13638 CG2 THR D 22 29. 227 -32. 351 -55. ,955 1.00 29. ,38 D c

ATOM 13642 C THR D 22 32. 866 -33. 767 -56. ,345 1.00 26. ,88 D c

ATOM 13643 O THR D 22 33. 679 -33. 619 -55. ,456 1.00 23. ,25 D 0

ATOM 13645 N CYS D 23 33. 222 -33. 920 -57. ,619 1.00 27. ,11 D N

ATOM 13646 CA CYS D 23 34. 543 -33. 626 -58. ,100 1.00 29. ,52 D c

ATOM 13648 CB CYS D 23 35. 399 -34. 892 -58. ,354 1.00 32. ,01 D c

ATOM 13651 SG CYS D 23 36. 043 -35. ,430 -56, .782 1.00 51. ,73 D s

ATOM 13653 C CYS D 23 34. 389 -32. 812 -59. .340 1.00 24. ,57 D c

ATOM 13654 O CYS D 23 33. 763 -33. 270 -60. .293 1.00 25. ,41 D 0

ATOM 13656 N ILE D 24 34. 950 -31. 604 -59. ,325 1.00 27. ,70 D N

ATOM 13657 CA ILE D 24 35. 008 -30. 779 -60. ,520 1.00 28. ,71 D c

ATOM 13659 CB ILE D 24 34. 573 -29. 322 -60. ,256 1.00 28. ,50 D c

ATOM 13661 CGI ILE D 24 33. 064 -29. 176 -59. .963 1.00 32. ,83 D c

ATOM 13664 CDl ILE D 24 32. 521 -30. 007 -58. ,894 1.00 38. ,35 D c

ATOM 13668 CG2 ILE D 24 34. 819 -28. 482 -61.518 1.00 28. ,22 D c

ATOM 13672 C ILE D 24 36. ,450 -30. ,828 -61. .057 1.00 32, ,49 D c

ATOM 13673 O ILE D 24 37. ,393 -30. ,727 -60. .285 1.00 32. ,44 D 0

ATOM 13675 N THR D 25 36. ,610 -30. 982 -62, .373 1.00 30. .24 D N

ATOM 13676 CA THR D 25 37. ,925 -31. 082 -62, .982 1.00 29. ,16 D c

ATOM 13678 CB THR D 25 38. 032 -32. ,313 -63, .901 1.00 29. ,13 D c

ATOM 13680 OGl THR D 25 37. ,091 -32. ,209 -64, .980 1.00 26. ,63 D 0

ATOM 13682 CG2 THR D 25 37. ,789 -33. ,588 -63, .111 1.00 24. ,56 D c cyno fD_Fab

ATOM 13686 C THR D 25 38. 308 -29. 820 -63. 762 1. 00 29. ,07 D C

ATOM 13687 0 THR D 25 37. 431 -29. ,079 -64. 202 1. 00 30. 03 D 0

ATOM 13689 N SER D 26 39. 616 -29. 585 -63. 938 1. 00 32. 08 D N

ATOM 13690 CA SER D 26 40. 068 -28. ,330 -64. 567 1. 00 36. ,35 D C

ATOM 13692 CB SER D 26 41. 580 -28. ,012 -64. 335 1. 00 40. ,56 D C

ATOM 13695 OG SER D 26 42. 504 -29. ,051 -64. 675 1. 00 38. ,34 D 0

ATOM 13697 C SER D 26 39. 687 -28. ,294 -66. 037 1. 00 39. ,18 D C

ATOM 13698 O SER D 26 39. 505 -27. ,218 -66. 613 1. 00 46. 60 D 0

ATOM 13700 N THR D 27 39. 522 -29. ,476 -66. 617 1. 00 36. ,43 D N

ATOM 13701 CA THR D 27 39. 239 -29. ,620 -68. 032 1. 00 34. ,46 D c

ATOM 13703 CB THR D 27 40. 579 -29. ,829 -68. 841 1. 00 36. ,28 D c

ATOM 13705 OGl THR D 27 40. 326 -29. ,660 -70. 243 1. 00 45. ,08 D 0

ATOM 13707 CG2 THR D 27 41.188 -31. ,179 -68. 606 1. 00 35. 39 D c

ATOM 13711 C THR D 27 38. 223 -30. ,753 -68. 282 1. 00 28. ,55 D c

ATOM 13712 O THR D 27 37. 869 -31. ,508 -67. 375 1. 00 31. ,91 D 0

ATOM 13714 N ASP D 28 37. 749 -30. ,850 -69. 517 1. 00 28. ,66 D N

ATOM 13715 CA ASP D 28 36. 725 -31. ,818 -69. 869 1. 00 28. .99 D c

ATOM 13717 CB ASP D 28 36. 017 -31. ,430 -71. 182 1. 00 20. ,71 D c

ATOM 13720 CG ASP D 28 34. 689 -32. ,223 -71. 410 1. 00 27. ,85 D c

ATOM 13721 ODl ASP D 28 33. 584 -31.650 -71. 254 1. 00 29. ,94 D 0

ATOM 13722 OD2 ASP D 28 34. 740 -33. 427 -71. 719 1. 00 27. ,91 D 0

ATOM 13723 C ASP D 28 37. 343 -33. ,209 -69. 973 1. 00 27. ,05 D c

ATOM 13724 O ASP D 28 38. 277 -33. 408 -70. 735 1. 00 31.78 D 0

ATOM 13726 N ILE D 29 36. 785 -34. ,170 -69. 239 1. 00 24. ,21 D N

ATOM 13727 CA ILE D 29 37. 358 -35. ,514 -69. 183 1. 00 23. ,76 D c

ATOM 13729 CB ILE D 29 37. 950 -35. ,824 -67. 763 1. 00 18. ,28 D c

ATOM 13731 CGI ILE D 29 36. 882 -35. ,862 -66. 682 1. 00 22. ,62 D c

ATOM 13734 CDl ILE D 29 37. 255 -36. ,886 -65. 550 1. 00 22. ,33 D c

ATOM 13738 CG2 ILE D 29 39. 036 -34. ,837 -67. 429 1. 00 13. ,90 D c

ATOM 13742 C ILE D 29 36. 425 -36. ,635 -69. 614 1. 00 27. ,66 D c

ATOM 13743 0 ILE D 29 36. 694 -37. 809 -69. 335 1. 00 31. ,60 D 0

ATOM 13745 N ASP D 30 35. 325 -36. 264 -70. 272 1. 00 28. ,90 D N

ATOM 13746 CA ASP D 30 34. 296 -37. ,195 -70. 710 1. 00 24. ,76 D c

ATOM 13748 CB ASP D 30 34. 872 -38. ,119 -71. 786 1. 00 24. ,79 D c

ATOM 13751 CG ASP D 30 35. 525 -37. ,347 -72. 894 1. 00 21. ,67 D c

ATOM 13752 ODl ASP D 30 34. 797 -36. ,665 -73. 623 1. 00 23. ,19 D 0

ATOM 13753 OD2 ASP D 30 36. 767 -37. ,391 -73. 049 1. 00 33. ,85 D 0

ATOM 13754 C ASP D 30 33. 701 -37. ,902 -69. 504 1. 00 27. ,74 D c

ATOM 13755 0 ASP D 30 33. 231 -37. ,235 -68. 587 1. 00 25. ,51 D 0

ATOM 13757 N ASP D 31 33. 702 -39. ,231 -69. 474 1. 00 25. ,33 D N

ATOM 13758 CA ASP D 31 33. 083 -39. ,952 -68. 342 1. 00 30. ,45 D c

ATOM 13760 CB ASP D 31 32. 075 -40. ,977 -68. 879 1. 00 34, ,21 D c

ATOM 13763 CG ASP D 31 32. 697 -41. ,927 -69. 879 1. 00 39. ,14 D c

ATOM 13764 ODl ASP D 31 33. 859 -41. ,677 -70. 285 1. GO 39. ,74 D 0

ATOM 13765 OD2 ASP D 31 32. 050 -42. ,918 -70. 266 1. 00 47, ,57 D 0

ATOM 13766 C ASP D 31 34. 133 -40. ,639 -67. 439 1. 00 29. ,18 D c

ATOM 13767 0 ASP D 31 33. 796 -41. ,460 -66. 586 1. 00 29. ,06 D 0

ATOM 13769 N ASP D 32 35. 399 -40. ,248 -67. 602 1. 00 27. ,83 D N

ATOM 13770 CA ASP D 32 36. 530 -40. ,943 -67. 012 1. 00 26. ,56 D c

ATOM 13772 CB ASP D 32 37. 769 -40. ,717 -67. 871 1. 00 24. ,54 D c

ATOM 13775 CG ASP D 32 37. 671 -41.412 -69. ,206 1. 00 26. .39 D c

ATOM 13776 ODl ASP D 32 37. 534 -42. ,644 -69. 203 1. 00 29. .06 D 0

ATOM 13777 OD2 ASP D 32 37. 731 -40. ,747 -70. ,249 1. 00 29. ,32 D 0

ATOM 13778 C ASP D 32 36. 785 -40. ,541 -65. ,558 1. 00 21. ,42 D c

ATOM 13779 0 ASP D 32 37. 847 -40. ,061 -65. 200 1. 00 13. ,97 D 0

ATOM 13781 N MET D 33 35. 780 -40. ,766 -64. ,723 1. 00 27. ,01 D N

ATOM 13782 CA MET D 33 35. 858 -40. ,471 -63. 310 1. 00 24. ,32 D c

ATOM 13784 CB MET D 33 34. 774 -39. ,476 -62. 915 1. 00 25. ,82 D c

ATOM 13787 CG MET D 33 34. 789 -39. ,026 -61. 441 1. 00 19. ,73 D c

ATOM 13790 SD MET D 33 36. 361 -38. ,333 -60. 880 1. 00 28. ,62 D s

ATOM 13791 CE MET D 33 36. 511 -36. ,793 -61. 766 1. 00 26, ,84 D c

ATOM 13795 C MET D 33 35. 637 -41. .762 -62. ,547 1. ,00 28, .66 D c

ATOM 13796 0 MET D 33 34. 733 -42. .538 -62. ,860 1. 00 36, .36 D 0

ATOM 13798 N ASN D 34 36. 426 -41. .938 -61. ,500 1. 00 28, .11 D N

ATOM 13799 CA ASN D 34 36. 346 -43. .093 -60. ,639 1. 00 21, .47 D c

ATOM 13801 CB ASN D 34 37. 655 -43. .876 -60. ,702 1. 00 21, .22 D c

ATOM 13804 CG ASN D 34 38. 053 -44, .231 -62. ,136 1. 00 19. .56 D c

ATOM 13805 ODl ASN D 34 37. 768 -45, ,311 -62. ,612 1. 00 21. .13 D 0 cyno fD_Fab

ATOM 13806 ND2 ASN D 34 38. ,667 -43. ,291 -62. ,824 1.00 15. .44 D N

ATOM 13809 C ASN D 34 36. .084 -42. ,643 -59. 208 1.00 18. ,56 D C

ATOM 13810 O ASN D 34 36. .369 -41. ,523 -58. ,837 1.00 25. ,59 D 0

ATOM 13812 N TRP D 35 35. ,564 -43. ,541 -58. ,399 1.00 20. ,95 D N

ATOM 13813 CA TRP D 35 35. ,350 -43. ,236 -56. ,985 1.00 18. 24 D C

ATOM 13815 CB TRP D 35 33. .878 -42. ,956 -56. 716 1.00 22. ,65 D C

ATOM 13818 CG TRP D 35 33. 393 -41. ,721 -57. 362 1.00 23. ,75 D C

ATOM 13819 CDl TRP D 35 32. ,830 -41. ,621 -58. 579 1.00 23. 33 D c

ATOM 13821 NEl TRP D 35 32. ,487 -40. ,334 -58. 833 1.00 23. ,97 D N

ATOM 13823 CE2 TRP D 35 32. ,822 -39. ,558 -57. 761 1.00 24. ,90 D c

ATOM 13824 CD2 TRP D 35 33. ,401 -40. ,404 -56. ,810 1.00 23. ,96 D c

ATOM 13825 CE3 TRP D 35 33. ,828 -39. ,863 -55. ,595 1.00 27. ,35 D c

ATOM 13827 CZ3 TRP D 35 33. ,678 -38. ,500 -55. 390 1.00 25. ,24 D c

ATOM 13829 CH2 TRP D 35 33. ,118 -37. ,677 -56. 376 1.00 24. ,10 D c

ATOM 13831 CZ2 TRP D 35 32. 678 -38. ,181 -57. 559 1.00 21.08 D c

ATOM 13833 C TRP D 35 35. ,771 -44. ,393 -56. ,164 1.00 17. ,08 D c

ATOM 13834 O TRP D 35 35. ,351 -45. ,532 -56. ,442 1.00 19. ,35 D 0

ATOM 13836 N TYR D 36 36. ,589 -44. ,096 -55. 153 1.00 21. ,50 D N

ATOM 13837 CA TYR D 36 37. ,095 -45. ,067 -54. 199 1.00 22. ,21 D c

ATOM 13839 CB TYR D 36 38. ,628 -44. ,988 -54. 098 1.00 26. ,01 D c

ATOM 13842 CG TYR D 36 39. ,397 -45. ,388 -55. 322 1.00 24. ,74 D c

ATOM 13843 CDl TYR D 36 40. 007 -46. ,640 -55. 395 1.00 25. ,44 D c

ATOM 13845 CEl TYR D 36 40. ,726 -47. ,025 -56. ,498 1.00 24. ,30 D c

ATOM 13847 CZ TYR D 36 40. ,866 -46. ,176 -57. ,569 1.00 24. ,66 D c

ATOM 13848 OH TYR D 36 41. ,607 -46. ,627 -58. ,641 1.00 26. ,35 D 0

ATOM 13850 CE2 TYR D 36 40. ,287 -44. ,916 -57. ,544 1.00 24. 23 D c

ATOM 13852 CD2 TYR D 36 39. ,545 -44. 520 -56. 408 1.00 26. ,43 D c

ATOM 13854 C TYR D 36 36. ,554 -44. ,794 -52. 802 1.00 22. ,90 D c

ATOM 13855 O TYR D 36 36. 283 -43. ,652 -52. 434 1.00 22. ,53 D 0

ATOM 13857 N GLN D 37 36. ,434 -45. ,868 -52. 029 1.00 23. ,80 D N

ATOM 13858 CA GLN D 37 36. 139 -45. ,816 -50. 600 1.00 24. ,57 D c

ATOM 13860 CB GLN D 37 34. 910 -46. ,693 -50. 318 1.00 25. ,51 D c

ATOM 13863 CG GLN D 37 34. 398 -46. ,722 -48. 883 1.00 26. 28 D c

ATOM 13866 CD GLN D 37 33. ,468 -47. ,905 -48. ,651 1.00 24. 39 D c

ATOM 13867 OEl GLN D 37 33. ,829 -49. ,048 -48. 928 1.00 24. ,49 D 0

ATOM 13868 NE2 GLN D 37 32. ,250 -47. ,629 -48. 191 1.00 25. ,14 D N

ATOM 13871 C GLN D 37 37. ,362 -46. ,338 -49. 845 1.00 26. ,54 D c

ATOM 13872 O GLN D 37 38. ,028 -47. ,293 -50. 290 1.00 26. 31 D 0

ATOM 13874 N GLN D 38 37. ,691 -45. ,695 -48. 731 1.00 24. 41 D N

ATOM 13875 CA GLN D 38 38. 710 -46. ,208 -47. 832 1.00 27. 86 D c

ATOM 13877 CB GLN D 38 40. ,043 -45. ,479 -48. 021 1.00 29. ,31 D c

ATOM 13880 CG GLN D 38 41. 189 -46. ,099 -47. 216 1.00 26. ,56 D c

ATOM 13883 CD GLN D 38 42. 511 -45. ,403 -47. 455 1.00 28. ,84 D c

ATOM 13884 OEl GLN D 38 43. 557 -46. ,038 -47. 583 1.00 27. ,15 D 0

ATOM 13885 NE2 GLN D 38 42. ,465 -44. ,097 -47. ,524 1.00 24. ,65 D N

ATOM 13888 C GLN D 38 38. ,298 -46. ,091 -46. ,373 1.00 28. ,26 D c

ATOM 13889 0 GLN D 38 38. ,010 -45. ,007 -45. ,887 1.00 29. ,09 D 0

ATOM 13891 N LYS D 39 38. ,289 -47. ,224 -45. 686 1.00 31.58 D N

ATOM 13892 CA LYS D 39 38. 109 -47. ,257 -44. ,245 1.00 37. ,31 D c

ATOM 13894 CB LYS D 39 37. 285 -48. ,476 -43. 866 1.00 40.00 D c

ATOM 13897 CG LYS D 39 35. .930 -48. ,488 -44. ,573 1.00 40. ,40 D c

ATOM 13900 CD LYS D 39 35. 001 -49. ,492 -43. 955 1.00 41. ,69 D c

ATOM 13903 CE LYS D 39 33. 662 -49. ,530 -44. 655 1.00 43. ,81 D c

ATOM 13906 NZ LYS D 39 32. 720 -50. ,444 -43. 930 1.00 45. ,82 D N

ATOM 13910 C LYS D 39 39. 479 -47. ,223 -43. 564 1.00 39. ,96 D c

ATOM 13911 0 LYS D 39 40. 495 -47. ,569 -44. 189 1.00 35. ,82 D 0

ATOM 13913 N PRO D 40 39. 522 -46. ,787 -42. ,289 1.00 42. ,77 D N

ATOM 13914 CA PRO D 40 40. ,769 -46. ,355 -41. ,638 1.00 44. ,48 D C

ATOM 13916 CB PRO D 40 40. ,305 -45. ,976 -40. ,223 1.00 47. ,51 D C

ATOM 13919 CG PRO D 40 38. 860 -45. ,650 -40. ,399 1.00 45, ,42 D C

ATOM 13922 CD PRO D 40 38. 387 -46. ,671 -41. ,359 1.00 45. ,74 D C

ATOM 13925 C PRO D 40 41. ,902 -47. ,381 -41. ,587 1.00 44. ,02 D C

ATOM 13926 0 PRO D 40 43. ,073 -47, ,002 -41. ,605 1.00 49. ,61 D 0

ATOM 13927 N GLY D 41 41. 575 -48. ,661 -41. ,535 1.00 38. 33 D N

ATOM 13928 CA GLY D 41 42. 627 -49. ,669 -41. ,486 1.00 43. ,53 D C

ATOM 13931 C GLY D 41 42. 995 -50. ,259 -42. 832 1.00 40.36 D C

ATOM 13932 0 GLY D 41 43. ,975 -50. ,986 -42. 940 1.00 43. ,33 D 0

ATOM 13934 N LYS D 42 42. 230 -49. ,914 -43. ,858 1.00 38. ,03 D N cyno f D. _Fab

ATOM 13935 CA LYS D 42 42. .079 -50. .757 -45. 027 1.00 37. ,97 D C

ATOM 13937 CB LYS D 42 40. .588 -51. .092 -45. 194 1.00 44. ,93 D C

ATOM 13940 CG LYS D 42 39. ,902 -51. 622 -43. 907 1.00 46. ,57 D C

ATOM 13943 CD LYS D 42 38. ,492 -52. ,194 -44. 185 1.00 48. ,07 D C

ATOM 13946 CE LYS D 42 37. ,761 -52. 618 -42. 870 1.00 51. ,72 D C

ATOM 13949 NZ LYS D 42 36. ,239 -52. 680 -42. 963 1.00 49. ,90 D N

ATOM 13953 C LYS D 42 42. ,620 -50. 123 -46. 305 1.00 30. ,72 D C

ATOM 13954 O LYS D 42 42. ,899 -48. 937 -46. 350 1.00 31. ,81 D 0

ATOM 13956 N VAL D 43 42. ,746 -50. ,945 -47. 340 1.00 31. ,34 D N

ATOM 13957 CA VAL D 43 43. ,212 -50. ,524 -48. 644 1.00 31. ,02 D C

ATOM 13959 CB VAL D 43 43. ,834 -51. ,721 -49. 427 1.00 31. ,82 D C

ATOM 13961 CGI VAL D 43 44. ,248 -51. .339 -50. 827 1.00 34. ,86 D c

ATOM 13965 CG2 VAL D 43 45. ,040 -52. 228 -48. 705 1.00 34. ,60 D c

ATOM 13969 C VAL D 43 42. ,048 -49. ,851 -49. 384 1.00 29. ,76 D c

ATOM 13970 O VAL D 43 40. 872 -50. ,098 -49. 076 1.00 30. ,34 D 0

ATOM 13972 N PRO D 44 42. 360 -48. 895 -50. 274 1.00 30. ,43 D N

ATOM 13973 CA PRO D 44 41. 251 -48. 331 -51. 029 1.00 28. ,97 D c

ATOM 13975 CB PRO D 44 41. 911 -47. ,224 -51.859 1.00 27. ,75 D c

ATOM 13978 CG PRO D 44 43. 126 -46. ,884 -51. 110 1.00 31. ,17 D c

ATOM 13981 CD PRO D 44 43. 617 -48. ,184 -50. 558 1.00 28. ,40 D c

ATOM 13984 C PRO D 44 40. 547 -49. ,371 -51. 892 1.00 22. 98 D c

ATOM 13985 O PRO D 44 41. 193 -50. ,285 -52. 436 1.00 27. 14 D 0

ATOM 13986 N LYS D 45 39. 225 -49. ,223 -51. 964 1.00 28. ,18 D N

ATOM 13987 CA LYS D 45 38. ,309 -50. ,041 -52. 767 1.00 31. ,51 D c

ATOM 13989 CB LYS D 45 37. ,226 -50. ,628 -51. 855 1.00 34. 90 D c

ATOM 13992 CG LYS D 45 36. 322 -51. ,678 -52. 463 1.00 37. 11 D c

ATOM 13995 CD LYS D 45 35. 368 -52. ,206 -51. 370 1.00 40. ,72 D c

ATOM 13998 CE LYS D 45 34. 075 -52. ,858 -51. 910 1.00 43. 90 D c

ATOM 14001 NZ LYS D 45 32. 936 -52. ,807 -50. 887 1.00 45. 13 D N

ATOM 14005 C LYS D 45 37. 654 -49. ,155 -53. 830 1.00 27. 81 D c

ATOM 14006 0 LYS D 45 37. 020 -48. ,158 -53. 495 1.00 25. 67 D 0

ATOM 14008 N LEU D 46 37. 823 -49. 518 -55. 106 1.00 21. ,45 D N

ATOM 14009 CA LEU D 46 37. 117 -48. 861 -56. 200 1.00 24. 98 D c

ATOM 14011 CB LEU D 46 37. 763 -49. ,178 -57. 545 1.00 16. 53 D c

ATOM 14014 CG LEU D 46 37. ,211 -48. ,458 -58. 767 1.00 21.09 D c

ATOM 14016 CDl LEU D 46 37. ,386 -47. Oil -58. 612 1.00 23. ,73 D c

ATOM 14020 CD2 LEU D 46 37. ,947 -48. ,879 -59. 986 1.00 18. ,78 D c

ATOM 14024 C LEU D 46 35. ,646 -49. ,306 -56. 201 1.00 27. ,40 D c

ATOM 14025 0 LEU D 46 35. ,335 -50. ,508 -56. 293 1.00 24. ,52 D 0

ATOM 14027 N LEU D 47 34. 754 -48. ,320 -56. 082 1.00 24. ,57 D N

ATOM 14028 CA LEU D 47 33. 320 -48. ,555 -56. 054 1.00 26. ,84 D c

ATOM 14030 CB LEU D 47 32. 681 -47. ,637 -55. 027 1.00 24. ,47 D c

ATOM 14033 CG LEU D 47 32. 997 -47. ,834 -53. 547 1.00 24. ,27 D c

ATOM 14035 CDl LEU D 47 31.893 -47. ,247 -52. 725 1.00 22. ,16 D c

ATOM 14039 CD2 LEU D 47 33. ,164 -49. ,286 -53. ,187 1.00 21. ,79 D c

ATOM 14043 C LEU D 47 32. ,660 -48. .306 -57. ,411 1.00 28. ,13 D c

ATOM 14044 0 LEU D 47 31. ,813 -49. ,087 -57. ,867 1.00 30. ,53 D 0

ATOM 14046 N ILE D 48 33. ,026 -47. .185 -58. ,014 1.00 27. ,03 D N

ATOM 14047 CA ILE D 48 32. ,441 -46. .699 -59. 258 1.00 25. .86 D c

ATOM 14049 CB ILE D 48 31. ,666 -45. ,385 -59. ,071 1.00 23. ,02 D c

ATOM 14051 CGI ILE D 48 30. ,579 -45. 480 -57. ,982 1.00 26. .89 D c

ATOM 14054 CDl ILE D 48 29. ,472 -46. 399 -58. 247 1.00 23. ,66 D c

ATOM 14058 CG2 ILE D 48 31. 099 -44. 886 -60. 408 1.00 24. ,89 D c

ATOM 14062 C ILE D 48 33. ,611 -46. ,370 -60. 167 1.00 22. ,34 D c

ATOM 14063 0 ILE D 48 34. ,566 -45. ,739 -59. 730 1.00 31.22 D 0

ATOM 14065 N SER D 49 33. ,534 -46. ,793 -61. 419 1.00 22. ,90 D N

ATOM 14066 CA SER D 49 34. .565 -46. .470 -62. ,422 1.00 24. .91 D c

ATOM 14068 CB SER D 49 35. ,225 -47. .759 -62. 898 1.00 23. ,68 D c

ATOM 14071 OG SER D 49 34. .286 -48. ,614 -63. 519 1.00 29. .51 D 0

ATOM 14073 C SER D 49 33. 980 -45. .690 -63. 605 1.00 27. ,66 D c

ATOM 14074 0 SER D 49 32. 820 -45. .292 -63. 578 1.00 22. .43 D 0

ATOM 14076 N GLY D 50 34. 785 -45. ,467 -64. 645 1.00 27. .77 D N

ATOM 14077 CA GLY D 50 34. 400 -44. .606 -65. 753 1.00 24. ,55 D c

ATOM 14080 C GLY D 50 33. ,040 -44. .954 -66. 303 1.00 30. .19 D c

ATOM 14081 0 GLY D 50 32. 669 -46. ,124 -66. 328 1.00 38. .06 D 0

ATOM 14083 N GLY D 51 32. 291 -43. .941 -66. 728 1.00 28. ,78 D N

ATOM 14084 CA GLY D 51 30. ,933 -44. ,131 -67. ,270 1.00 28. .38 D c

ATOM 14087 C GLY D 51 29. .881 -44. ,310 -66. .188 1.00 27. .91 D c cyno fD_Fab

ATOM 14088 O GLY D 51 28. ,766 -44. ,781 -66. ,455 1.00 26. 87 D 0

ATOM 14090 N ASN D 52 30. 251 -43. ,935 -64. ,967 1.00 30. 53 D N

ATOM 14091 CA ASN D 52 29. 437 -44. ,166 -63. ,782 1.00 29. 12 D C

ATOM 14093 CB ASN D 52 28. 248 -43. 214 -63. ,829 1.00 34. 31 D C

ATOM 14096 CG ASN D 52 28. 694 -41. ,765 -63. 733 1.00 36. 82 D C

ATOM 14097 ODl ASN D 52 29. 440 -41. 427 -62. 824 1.00 40. 42 D 0

ATOM 14098 ND2 ASN D 52 28. 273 -40. ,913 -64. 686 1.00 33. 25 D N

ATOM 14101 C ASN D 52 29. 051 -45. ,645 -63. 585 1.00 30. 61 D c

ATOM 14102 O ASN D 52 27. 912 -45. 974 -63. 238 1.00 33. 36 D 0

ATOM 14104 N TH D 53 30. 043 -46. 522 -63. 784 1.00 22. 05 D N

ATOM 14105 CA THR D 53 29. 863 -47. ,979 -63. ,793 1.00 20. 62 D c

ATOM 14107 CB THR D 53 30. 896 -48. ,631 -64. 758 1.00 22. 22 D c

ATOM 14109 OG1 THR D 53 30. 714 -48. ,078 -66. 057 1.00 26. 58 D 0

ATOM 14111 CG2 THR D 53 30. 791 -50. ,175 -64. 830 1.00 19. 41 D c

ATOM 14115 C THR D 53 30. 067 -48. ,515 -62. 371 1.00 24. 84 D c

ATOM 14116 0 THR D 53 31. 184 -48. ,513 -61.856 1.00 25. 16 D 0

ATOM 14118 N LEU D 54 28. 977 -48. ,948 -61. 739 1.00 27. 31 D N

ATOM 14119 CA LEU D 54 29. 027 -49. ,594 -60. 428 1.00 29. 35 D c

ATOM 14121 CB LEU D 54 27. 598 -49. 808 -59. 907 1.00 28. 32 D c

ATOM 14124 CG LEU D 54 27. 398 -50. 299 -58. 474 1.00 25. 72 D c

ATOM 14126 CDl LEU D 54 27. 834 -49. 269 -57. 444 1.00 24. 93 D c

ATOM 14130 CD2 LEU D 54 25. 952 -50. 637 -58. 284 1.00 29. 74 D c

ATOM 14134 C LEU D 54 29. 771 -50. ,927 -60. ,530 1.00 29. 32 D c

ATOM 14135 O LEU D 54 29. 413 -51. ,776 -61. ,340 1.00 28. 60 D 0

ATOM 14137 N ARG D 55 30. 829 -51. ,104 -59. ,740 1.00 31. 51 D N

ATOM 14138 CA ARG D 55 31. 553 -52. ,375 -59. 738 1.00 33. 30 D c

ATOM 14140 CB ARG D 55 32. 850 -52. ,277 -58. 928 1.00 40. 35 D c

ATOM 14143 CG ARG D 55 33. 912 -51. 333 -59. 501 1.00 44. 95 D c

ATOM 14146 CD ARG D 55 34. 178 -51. ,515 -61.024 1.00 46. 02 D c

ATOM 14149 NE ARG D 55 35. 576 -51. 228 -61. 345 1.00 48. 65 D N

ATOM 14151 cz ARG D 55 36. 140 -51.346 -62. 548 1.00 49. 14 D c

ATOM 14152 NHl ARG D 55 35. 425 -51. 741 -63. 593 1.00 54. 73 D N

ATOM 14155 NH2 ARG D 55 37. 427 -51. 061 -62. 709 1.00 46. 65 D N

ATOM 14158 C ARG D 55 30. 715 -53. ,522 -59. ,174 1.00 32. 58 D C

ATOM 14159 0 ARG D 55 29. 976 -53. ,326 -58. ,215 1.00 34. 68 D 0

ATOM 14161 N PRO D 56 30. 843 -54. ,736 -59. ,759 1.00 36. 36 D N

ATOM 14162 CA PRO D 56 30. 186 -55. 933 -59. 233 1.00 35. 21 D C

ATOM 14164 CB PRO D 56 30. 855 -57. ,065 -60. ,016 1.00 38. 48 D C

ATOM 14167 CG PRO D 56 31. 165 -56. ,452 -61. ,319 1.00 39. 04 D C

ATOM 14170 CD PRO D 56 31. 581 -55. ,040 -60. ,999 1.00 37. 26 D c

ATOM 14173 C PRO D 56 30. 393 -56. ,128 -57. 732 1.00 35. 33 D c

ATOM 14174 0 PRO D 56 31. 528 -56. ,135 -57. 265 1.00 36. 15 D 0

ATOM 14175 N GLY D 57 29. 299 -56. ,266 -56. 993 1.00 26. 46 D N

ATOM 14176 CA GLY D 57 29. 378 -56. ,521 -55. 566 1.00 31.17 D c

ATOM 14179 C GLY D 57 29. 219 -55. ,302 -54. ,683 1.00 29. 16 D c

ATOM 14180 0 GLY D 57 29. 114 -55. ,441 -53. ,466 1.00 34. 16 D 0

ATOM 14182 N VAL D 58 29. 219 -54. ,111 -55. ,291 1.00 34. 24 D N

ATOM 14183 CA VAL D 58 29. 083 -52. ,851 -54. ,562 1.00 29. 71 D c

ATOM 14185 CB VAL D 58 29. 877 -51. ,698 -55. ,235 1.00 28. 16 D c

ATOM 14187 CGI VAL D 58 29. 707 -50. ,394 -54. ,454 1.00 19. 29 D c

ATOM 14191 CG2 VAL D 58 31. 369 -52. ,075 -55. ,322 1.00 25. 50 D c

ATOM 14195 C VAL D 58 27. 588 -52. 560 -54. ,463 1.00 31. 44 D c

ATOM 14196 0 VAL D 58 26. 861 -52. ,688 -55. ,459 1.00 29. 45 D 0

ATOM 14198 N PRO D 59 27. 098 -52. ,260 -53. ,245 1.00 29. 19 D N

ATOM 14199 CA PRO D 59 25. 680 -52. ,036 -53. ,071 1.00 28. 16 D c

ATOM 14201 CB PRO D 59 25. 588 -51. ,629 -51. ,606 1.00 27. 76 D c

ATOM 14204 CG PRO D 59 26. 683 -52. ,323 -50. ,998 1.00 28. 56 D c

ATOM 14207 CD PRO D 59 27. 792 -52. ,181 -51. ,954 1.00 29. 87 D c

ATOM 14210 C PRO D 59 25. 098 -50. ,969 -53. ,992 1.00 26. 31 D c

ATOM 14211 0 PRO D 59 25. 759 -49. ,984 -54. ,310 1.00 29. 09 D 0

ATOM 14212 N SER D 60 23. 859 -51. ,177 -54. ,416 1.00 29. 56 D N

ATOM 14213 CA SER D 60 23. 217 -50. ,340 -55. 423 1.00 29. 02 D C

ATOM 14215 CB SER D 60 21. 908 -51. ,004 -55. 897 1.00 38. 41 D C

ATOM 14218 OG SER D 60 21. 134 -51. ,460 -54. 786 1.00 42. 50 D 0

ATOM 14220 C SER D 60 22. 935 -48. ,919 -54. ,952 1.00 30. 03 D C

ATOM 14221 0 SER D 60 22. 784 -48. ,024 -55. 783 1.00 24. 17 D 0

ATOM 14223 N ARG D 61 22. 871 -48. ,698 -53. 632 1.00 26. 60 D N

ATOM 14224 CA ARG D 61 22. 708 -47, .343 -53. ,100 1.00 26. 75 D C cyno fD_Fab

ATOM 14226 CB ARG D 61 22. .591 -47. ,364 -51. ,581 1.00 28. ,78 D C

ATOM 14229 CG ARG D 61 23. .774 -47. ,952 -50. ,885 1.00 31. ,92 D C

ATOM 14232 CD ARG D 61 23. ,630 -47. ,815 -49. ,400 1.00 32. ,72 D C

ATOM 14235 NE ARG D 61 24. .797 -48. ,355 -48. ,726 1.00 36. ,88 D N

ATOM 14237 CZ ARG D 61 24. ,948 -49. ,627 -48. ,372 1.00 38. ,14 D C

ATOM 14238 NHl ARG D 61 24. ,016 -50. ,533 -48. 648 1.00 44. ,10 D N

ATOM 14241 NH2 ARG D 61 26.056 -50. ,001 -47. 754 1.00 34. ,40 D N

ATOM 14244 C ARG D 61 23. ,842 -46. ,400 -53. 516 1.00 23. ,75 D C

ATOM 14245 O ARG D 61 23. ,699 -45. ,185 -53. ,459 1.00 24. ,94 D 0

ATOM 14247 N PHE D 62 24. ,971 -46. ,967 -53. ,927 1.00 30. ,31 D N

ATOM 14248 CA PHE D 62 26. ,062 -46. ,197 -54. ,486 1.00 26. ,78 D C

ATOM 14250 CB PHE D 62 27. ,391 -46. ,933 -54. ,285 1.00 28. ,56 D C

ATOM 14253 CG PHE D 62 27. ,852 -46. ,959 -52. ,861 1.00 27. ,28 D C

ATOM 14254 CDl PHE D 62 28. ,552 -45. ,890 -52. 339 1.00 27. ,71 D c

ATOM 14256 CEl PHE D 62 28. ,970 -45. 906 -51. ,027 1.00 29. ,22 D c

ATOM 14258 CZ PHE D 62 28. ,710 -47. ,001 -50. ,237 1.00 28. ,43 D c

ATOM 14260 CE2 PHE D 62 28. ,025 -48. ,076 -50. 747 1.00 26. ,39 D c

ATOM 14262 CD 2 PHE D 62 27. ,598 -48. ,053 -52. 051 1.00 25. ,00 D c

ATOM 14264 C PHE D 62 25. ,825 -45. ,959 -55. 975 1.00 30. ,49 D c

ATOM 14265 0 PHE D 62 25. ,576 -46. ,893 -56. 733 1.00 35. 90 D 0

ATOM 14267 N SER D 63 25. ,912 -44. ,706 -56. ,400 1.00 32. ,22 D N

ATOM 14268 CA SER D 63 25. ,820 -44. ,401 -57. 814 1.00 26. ,18 D C

ATOM 14270 CB SER D 63 24. ,358 -44. ,259 -58. 243 1.00 28. ,90 D c

ATOM 14273 OG SER D 63 23. ,772 -43. ,095 -57. 709 1.00 28. ,18 D 0

ATOM 14275 C SER D 63 26. ,570 -43. ,148 -58. 113 1.00 27. ,36 D c

ATOM 14276 0 SER D 63 26. ,681 -42. ,262 -57. 265 1.00 24. 28 D 0

ATOM 14278 N GLY D 64 27. ,107 -43. ,085 -59. 328 1.00 24. 83 D N

ATOM 14279 CA GLY D 64 27. ,759 -41.900 -59. 831 1.00 25. 07 D c

ATOM 14282 C GLY D 64 26. ,955 -41. ,245 -60. 937 1.00 27. ,82 D c

ATOM 14283 0 GLY D 64 26. ,152 -41.899 -61.604 1.00 29. ,25 D 0

ATOM 14285 N SER D 65 27. ,197 -39. ,954 -61. 156 1.00 28. ,23 D N

ATOM 14286 CA SER D 65 26. ,547 -39. ,210 -62. 229 1.00 31. ,92 D c

ATOM 14288 CB SER D 65 25. 229 -38. ,606 -61. 751 1.00 34. 45 D c

ATOM 14291 OG SER D 65 25. ,445 -37. ,740 -60. 650 1.00 38. ,75 D 0

ATOM 14293 C SER D 65 27. ,413 -38. ,074 -62. ,731 1.00 28. ,36 D c

ATOM 14294 0 SER D 65 28. ,176 -37. ,502 -61. 988 1.00 22. 28 D 0

ATOM 14296 N GLY D 66 27. 250 -37. ,732 -64. ,000 1.00 28. ,51 D N

ATOM 14297 CA GLY D 66 27. 882 -36. ,556 -64. ,539 1.00 28. 37 D c

ATOM 14300 C GLY D 66 28. 931 -36. ,939 -65. 529 1.00 26. 52 D c

ATOM 14301 0 GLY D 66 29. 410 -38. ,063 -65. 539 1.00 35. ,55 D 0

ATOM 14303 N SER D 67 29. ,241 -36.001 -66. 408 1.00 21. ,98 D N

ATOM 14304 CA SER D 67 30. 272 -36. ,209 -67. 395 1.00 29. ,87 D c

ATOM 14306 CB SER D 67 29. 744 -37. ,081 -68. 546 1.00 28. ,03 D c

ATOM 14309 OG SER D 67 29. ,027 -36. ,318 -69. 495 1.00 33. ,55 D 0

ATOM 14311 C SER D 67 30. ,759 -34. ,827 -67. 842 1.00 25. ,47 D c

ATOM 14312 0 SER D 67 30. ,026 -33. ,858 -67. 765 1.00 37. ,07 D 0

ATOM 14314 N GLY D 68 32. ,008 -34. ,734 -68. 253 1.00 30. ,12 D N

ATOM 14315 CA GLY D 68 32. ,576 -33. ,477 -68. ,703 1.00 30. ,71 D c

ATOM 14318 C GLY D 68 33. ,501 -33. ,029 -67. ,621 1.00 24. ,62 D c

ATOM 14319 0 GLY D 68 34. ,577 -33. ,566 -67. ,497 1.00 27. ,36 D 0

ATOM 14321 N THR D 69 33. ,060 -32. ,068 -66. ,813 1.00 29. ,97 D N

ATOM 14322 CA THR D 69 33. ,871 -31. ,529 -65. ,716 1.00 26. ,63 D C

ATOM 14324 CB THR D 69 34. 061 -30. ,007 -65. ,837 1.00 29. ,25 D C

ATOM 14326 OGl THR D 69 32. ,792 -29. ,361 -65. ,695 1.00 22. ,95 D 0

ATOM 14328 CG2 THR D 69 34. ,760 -29. ,591 -67. ,182 1.00 20. ,12 D C

ATOM 14332 C THR D 69 33. ,263 -31. ,771 -64. 336 1.00 26. ,86 D C

ATOM 14333 0 THR D 69 33. ,988 -31. ,723 -63. ,359 1.00 25. ,38 D 0

ATOM 14335 N ASP D 70 31. ,950 -32. ,023 -64. ,271 1.00 26. ,49 D N

ATOM 14336 CA ASP D 70 31. ,173 -32. .035 -63. ,022 1.00 26. ,27 D c

ATOM 14338 CB ASP D 70 29. ,943 -31.115 -63. ,135 1.00 29. ,07 D c

ATOM 14341 CG ASP D 70 30. ,293 -29. ,614 -63. ,281 1.00 31. ,26 D c

ATOM 14342 001 ASP D 70 31.473 -29. ,209 -63. 373 1.00 26. ,00 D 0

ATOM 14343 002 ASP D 70 29. 333 -28. ,820 -63. ,301 1.00 32. ,48 D 0

ATOM 14344 C ASP D 70 30. ,689 -33. ,450 -62. 652 1.00 24. ,36 D c

ATOM 14345 0 ASP D 70 29. ,790 -34. ,005 -63. ,286 1.00 23. ,67 D 0

ATOM 14347 N PHE D 71 31. ,261 -34. ,021 -61. ,600 1.00 24. ,90 D N

ATOM 14348 CA PHE D 71 31. ,010 -35. ,425 -61. ,247 1.00 22. ,55 D c

ATOM 14350 CB PHE D 71 32. ,288 -36. ,241 -61. ,431 1.00 19. ,80 D c ATOM 14353 CG PHE D 71 -62.,876 1.00 19.,54 D C

ATOM 14354 CDl PHE D 71 -63. ,790 1.00 18. ,61 D C

ATOM 14356 CEl PHE D 71 -65. ,113 1.00 25. ,10 D C

ATOM 14358 CZ PHE D 71 -65. ,529 1.00 20. 59 D C

ATOM 14360 CE2 PHE D 71 -64. ,647 1.00 19. ,12 D C

ATOM 14362 CD2 PHE D 71 -63. ,291 1.00 16. ,91 D C

ATOM 14364 C PHE D 71 -59. ,827 1.00 21. ,61 D C

ATOM 14365 O PHE D 71 -58. 980 1.00 28. ,30 D 0

ATOM 14367 N THR D 72 -59. ,613 1.00 25. ,78 D N

ATOM 14368 CA THR D 72 -58. ,336 1.00 25. ,62 D C

ATOM 14370 CB THR D 72 -58. ,385 1.00 23. ,90 D C

ATOM 14372 OGl THR D 72 -58. ,875 1.00 25. ,14 D 0

ATOM 14374 CG2 THR D 72 26. ,783 -35. 968 -57. ,045 1.00 24. ,08 D c

ATOM 14378 C THR D 72 28. ,805 -38. 106 -58. ,009 1.00 25. ,39 D c

ATOM 14379 O THR D 72 28. ,464 -38. 923 -58. ,844 1.00 27. ,12 D 0

ATOM 14381 N LEU D 73 29. ,144 -38. 423 -56. ,773 1.00 26. 32 D N

ATOM 14382 CA LEU D 73 28. ,881 -39. 699 -56. ,180 1.00 23. ,73 D c

ATOM 14384 CB LEU D 73 30. 111 -40. 174 -55. ,428 1.00 22. ,91 D c

ATOM 14387 CG LEU D 73 29. ,978 -41. 318 -54. ,447 1.00 24. ,18 D c

ATOM 14389 CDl LEU D 73 29. ,655 -42. 561 -55. ,160 1.00 19. ,36 D c

ATOM 14393 CD2 LEU D 73 31. ,275 -41. 487 -53. ,661 1.00 19. ,61 D c

ATOM 14397 C LEU D 73 27. ,760 -39. 475 -55. ,181 1.00 24. 08 D c

ATOM 14398 O LEU D 73 27. ,847 -38. 587 -54. ,343 1.00 28. ,07 D 0

ATOM 14400 N THR D 74 26. ,741 -40. 324 -55. 255 1.00 22. ,40 D N

ATOM 14401 CA THR D 74 25. 577 -40. 246 -54. 387 1.00 28. ,50 D c

ATOM 14403 CB THR D 74 24. 351 -39. 945 -55. ,231 1.00 27. ,25 D c

ATOM 14405 OGl THR D 74 24. 503 -38. 624 -55. 765 1.00 24. ,36 D 0

ATOM 14407 CG2 THR D 74 23. 064 -40. 034 -54. ,413 1.00 22. ,43 D c

ATOM 14411 C THR D 74 25. ,433 -41. 561 -53. ,643 1.00 25. ,66 D c

ATOM 14412 O THR D 74 25. 540 -42. 606 -54. 241 1.00 32. ,11 D 0

ATOM 14414 N ILE D 75 25. 291 -41. 499 -52. 326 1.00 22. ,22 D N

ATOM 14415 CA ILE D 75 24. 803 -42. 646 -51. 549 1.00 27. ,18 D c

ATOM 14417 CB ILE D 75 25. 612 -42. 883 -50. 224 1.00 23. ,69 D c

ATOM 14419 CGI ILE D 75 27. 135 -42. 724 -50. ,454 1.00 21. ,60 D c

ATOM 14422 CDl ILE D 75 27. ,970 -42. 768 -49. ,214 1.00 24. ,13 D c

ATOM 14426 CG2 ILE D 75 25. ,317 -44. 269 -49. ,661 1.00 19. ,91 D c

ATOM 14430 C ILE D 75 23. 331 -42. 375 -51. 208 1.00 29. ,24 D c

ATOM 14431 O ILE D 75 23. ,048 -41. 487 -50. ,424 1.00 31. 02 D 0

ATOM 14433 N SER D 76 22. 409 -43. 172 -51. ,752 1.00 33. 66 D N

ATOM 14434 CA SER D 76 20. ,962 -42. 875 -51. ,659 1.00 32. 65 D c

ATOM 14436 CB SER D 76 20. ,178 -43. 680 -52. 693 1.00 35. 78 D c

ATOM 14439 OG SER D 76 20. 217 -45. 077 -52. 399 1.00 41. ,64 D 0

ATOM 14441 C SER D 76 20. ,354 -43. 109 -50. 281 1.00 33. ,79 D c

ATOM 14442 O SER D 76 19. ,371 -42. 450 -49. 900 1.00 35. 88 D 0

ATOM 14444 N SER D 77 20. ,923 -44. 053 -49. ,544 1.00 33. ,75 D N

ATOM 14445 CA SER D 77 20. ,465 -44. 364 -48. ,201 1.00 31. ,69 D c

ATOM 14447 CB SER D 77 19. ,432 -45. 497 -48. ,225 1.00 32. ,75 D c

ATOM 14450 OG SER D 77 19. ,199 -45. 983 -46. ,927 1.00 39. ,45 D 0

ATOM 14452 C SER D 77 21.678 -44. ,758 -47. ,388 1.00 31.73 D c

ATOM 14453 O SER D 77 22. ,107 -45. ,905 -47. ,423 1.00 35. ,95 D 0

ATOM 14455 N LEU D 78 22. ,217 -43. ,789 -46. ,653 1.00 28. ,56 D N

ATOM 14456 CA LEU D 78 23. ,472 -43. 944 -45. ,967 1.00 29. ,79 D C

ATOM 14458 CB LEU D 78 23. ,908 -42. 607 -45. ,365 1.00 29. .88 D C

ATOM 14461 CG LEU D 78 25. ,254 -42. 579 -44. ,639 1.00 28. ,42 D c

ATOM 14463 CDl LEU D 78 26. ,351 -42. 861 -45. ,640 1.00 23. ,97 D c

ATOM 14467 CD2 LEU D 78 25. ,479 -41. 253 -43. ,933 1.00 27. ,13 D c

ATOM 14471 C LEU D 78 23. ,324 -44. ,990 -44. ,872 1.00 29. .47 D c

ATOM 14472 O LEU D 78 22. ,466 -44. 858 -44. ,009 1.00 26. .89 D 0

ATOM 14474 N GLN D 79 24. ,144 -46. 040 -44. ,943 1.00 29. ,19 D N

ATOM 14475 CA GLN D 79 24. ,121 -47. 110 -43. ,956 1.00 30. ,05 D c

ATOM 14477 CB GLN D 79 24. ,123 -48. ,497 -44. ,622 1.00 28. .19 D c

ATOM 14480 CG GLN D 79 22. ,892 -48. ,854 -45. ,462 1.00 29. ,10 D c

ATOM 14483 CD GLN D 79 21. ,585 -48. 584 -44. ,758 1.00 29. ,94 D c

ATOM 14484 OEl GLN D 79 21. ,339 -49. ,097 -43. ,679 1.00 29. ,19 D 0

ATOM 14485 NE2 GLN D 79 20. ,739 -47. ,765 -45. ,368 1.00 34. ,70 D N

ATOM 14488 C GLN D 79 25. ,341 -46. 944 -43. ,056 1.00 30. ,15 D c

ATOM 14489 O GLN D 79 26. ,330 -46. 336 -43. ,457 1.00 26. ,76 D 0

ATOM 14491 N PRO D 80 25. ,275 -47. ,478 -41. .830 1.00 30, .40 D N cyno fD_Fab

ATOM 14492 CA PRO D 80 26. ,376 -47. ,363 -40. ,863 1.00 31. 68 D C

ATOM 14494 CB PRO D 80 25. ,945 -48. ,308 -39. ,749 1.00 31. 64 D C

ATOM 14497 CG PRO D 80 24. ,493 -48. 325 -39. ,827 1.00 32. 58 D C

ATOM 14500 CD PRO D 80 24. ,140 -48. 216 -41. ,261 1.00 31. 88 D C

ATOM 14503 C PRO D 80 27. ,756 -47. 764 -41. ,399 1.00 28. 99 D c

ATOM 14504 O PRO D 80 28. ,746 -47. 109 -41. ,092 1.00 28. 58 D 0

ATOM 14505 N GLU D 81 27. ,797 -48. ,819 -42, .205 1.00 28. 68 D N

ATOM 14506 CA GLU D 81 29. ,045 -49. ,340 -42. .775 1.00 30. 29 D C

ATOM 14508 CB GLU D 81 28. ,845 -50. ,761 -43. ,307 1.00 28. 25 D c

ATOM 14511 CG GLU D 81 27. ,828 -50. ,918 -44. ,423 1.00 34. 74 D c

ATOM 14514 CD GLU D 81 26. ,494 -51. ,513 -43. ,965 1.00 43. 46 D c

ATOM 14515 OEl GLU D 81 25. ,899 -51. ,057 -42. ,940 1.00 40. 82 D 0

ATOM 14516 OE2 GLU D 81 26. ,041 -52. ,451 -44. ,654 1.00 47. 54 D 0

ATOM 14517 C GLU D 81 29. ,611 -48. 473 -43. ,895 1.00 30. 45 D c

ATOM 14518 O GLU D 81 30. ,666 -48. 784 -44. ,443 1.00 32. 05 D 0

ATOM 14520 N ASP D 82 28. ,886 -47. 417 -44. ,257 1.00 31. 69 D N

ATOM 14521 CA ASP D 82 29. ,332 -46. 470 -45. ,272 1.00 28. 01 D c

ATOM 14523 CB ASP D 82 28. ,118 -45. ,842 -45. .958 1.00 32. 15 D c

ATOM 14526 CG ASP D 82 27. ,327 -46. ,851 -46. ,738 1.00 30. 80 D c

ATOM 14527 ODl ASP D 82 27. ,942 -47. ,847 -47. ,173 1.00 35. 80 D 0

ATOM 14528 OD2 ASP D 82 26. 111 -46. ,664 -46. ,904 1.00 27. 92 D 0

ATOM 14529 C ASP D 82 30. 265 -45. ,381 -44. ,743 1.00 26. 99 D c

ATOM 14530 O ASP D 82 30. 785 -44. 600 -45. ,545 1.00 23. 23 D 0

ATOM 14532 N VAL D 83 30. 487 -45. 319 -43. ,422 1.00 25. 48 D N

ATOM 14533 CA VAL D 83 31. ,464 -44. 376 -42, ,878 1.00 27. 11 D c

ATOM 14535 CB VAL D 83 31. ,436 -44. 223 -41, ,302 1.00 31. 38 D c

ATOM 14537 CGI VAL D 83 30. 059 -43. 713 -40. ,827 1.00 32. 69 D c

ATOM 14541 CG2 VAL D 83 31.825 -45. ,494 -40. ,585 1.00 29. 63 D c

ATOM 14545 C VAL D 83 32. ,864 -44. ,748 -43. .403 1.00 28. 07 D c

ATOM 14546 O VAL D 83 33. ,378 -45. 855 -43. .185 1.00 26. 35 D 0

ATOM 14548 N ALA D 84 33. ,446 -43. ,807 -44. ,133 1.00 23. 32 D N

ATOM 14549 CA ALA D 84 34. ,720 -43. 993 -44. ,802 1.00 25. 07 D c

ATOM 14551 CB ALA D 84 34. ,545 -44. 943 -45. ,992 1.00 26. 25 D c

ATOM 14555 C ALA D 84 35. ,157 -42. 620 -45. ,278 1.00 26. 17 D c

ATOM 14556 O ALA D 84 34. 410 -41. 639 -45. ,107 1.00 21. 62 D 0

ATOM 14558 N THR D 85 36. ,360 -42. 528 -45. ,843 1.00 24. 62 D N

ATOM 14559 CA THR D 85 36. ,709 -41. 384 -46. ,665 1.00 21. 77 D c

ATOM 14561 CB THR D 85 38. 121 -40. 820 -46. ,367 1.00 20. 79 D c

ATOM 14563 OG1 THR D 85 38. ,107 -40. ,247 -45, .066 1.00 27. 09 D 0

ATOM 14565 CG2 THR D 85 38. ,504 -39. ,693 -47. .343 1.00 21. 26 D c

ATOM 14569 C THR D 85 36. ,547 -41. ,856 -48, .092 1.00 27. 22 D c

ATOM 14570 O THR D 85 36. ,887 -42. ,997 -48. .414 1.00 17. ,46 D 0

ATOM 14572 N TYR D 86 35. ,962 -40. ,985 -48. .916 1.00 28. 12 D N

ATOM 14573 CA TYR D 86 35. ,712 -41. ,235 -50. .313 1.00 22. 80 D c

ATOM 14575 CB TYR D 86 34. ,207 -40. 997 -50. .614 1.00 22. 25 D c

ATOM 14578 CG TYR D 86 33. ,298 -42. ,037 -49. .948 1.00 20. 76 D c

ATOM 14579 CDl TYR D 86 32. ,927 -43. ,191 -50. ,612 1.00 23. 74 D c

ATOM 14581 CEl TYR D 86 32. ,155 -44. ,176 -49. ,986 1.00 19. 70 D c

ATOM 14583 CZ TYR D 86 31. ,753 -43. ,999 -48. ,677 1.00 22. 91 D c

ATOM 14584 OH TYR D 86 30. ,989 -44. ,963 -48, .036 1.00 19. ,15 D 0

ATOM 14586 CE2 TYR D 86 32. ,128 -42. ,865 -48, .002 1.00 21. ,28 D c

ATOM 14588 CD2 TYR D 86 32. ,894 -41. ,897 -48, .627 1.00 17. ,54 D c

ATOM 14590 C TYR D 86 36. ,669 -40. ,351 -51, .142 1.00 25. ,73 D c

ATOM 14591 O TYR D 86 36. ,858 -39. ,173 -50. .817 1.00 25. 01 D 0

ATOM 14593 N TYR D 87 37. ,302 -40. ,944 -52, .165 1.00 22. 30 D N

ATOM 14594 CA TYR D 87 38. 235 -40. ,245 -53, .074 1.00 21. 15 D c

ATOM 14596 CB TYR D 87 39. ,681 -40. ,789 -52, .972 1.00 22. 58 D c

ATOM 14599 CG TYR D 87 40. ,291 -40. ,635 -51, .617 1.00 17. ,27 D c

ATOM 14600 CDl TYR D 87 40. ,969 -39. ,470 -51. .271 1.00 20. ,42 D c

ATOM 14602 CEl TYR D 87 41. ,483 -39. ,293 -50, .009 1.00 15. 93 D c

ATOM 14604 CZ TYR D 87 41. ,348 -40. ,303 -49, .089 1.00 18. 29 D c

ATOM 14605 OH TYR D 87 41. ,854 -40. ,141 -47, .838 1.00 21.68 D 0

ATOM 14607 CE2 TYR D 87 40. ,666 -41. ,466 -49, .394 1.00 14. ,46 D c

ATOM 14609 CD2 TYR D 87 40. ,146 -41.630 -50, .652 1.00 17. ,04 D c

ATOM 14611 C TYR D 87 37. 809 -40. ,434 -54, .510 1.00 20. 23 D c

ATOM 14612 O TYR D 87 37. 623 -41. ,555 -54, .954 1.00 21. ,73 D 0

ATOM 14614 N CYS D 88 37. 675 -39. ,335 -55, .247 1.00 20. ,76 D N

ATOM 14615 CA CYS D 88 37. 525 -39. ,422 -56, .682 1.00 23. ,97 D c cyno fD_Fab

ATOM 14617 CB CYS D 88 36. .786 -38. ,217 -57. 250 1. 00 31. .52 D C

ATOM 14620 SG CYS D 88 37. .593 -36. 643 -57. 101 1. 00 34. .61 D S

ATOM 14622 C CYS D 88 38. .882 -39. 604 -57. 348 1. 00 23. ,12 D C

ATOM 14623 O CYS D 88 39. ,927 -39. 331 -56. 754 1. 00 22. ,11 D 0

ATOM 14625 N LEU D 89 38. ,851 -40. 131 -58. 567 1. 00 23. ,55 D N

ATOM 14626 CA LEU D 89 40. ,046 -40. 273 -59. 350 1. 00 23. ,64 D C

ATOM 14628 CB LEU D 89 40, ,697 -41. 642 -59. 151 1. 00 21.20 D C

ATOM 14631 CG LEU D 89 41. ,865 -41. 890 -60. 131 1. 00 23. ,42 D C

ATOM 14633 CDl LEU D 89 43. .189 -41. 499 -59. 535 1. 00 16.08 D c

ATOM 14637 CD2 LEU D 89 41. .886 -43. 325 -60. 534 1. 00 21. .64 D c

ATOM 14641 C LEU D 89 39. ,741 -40. 044 -60. 824 1. 00 22. ,50 D c

ATOM 14642 O LEU D 89 39. ,035 -40. 795 -61. 473 1. 00 24. ,42 D 0

ATOM 14644 N GLN D 90 40. ,383 -39. 024 -61. 332 1. 00 21. ,44 D N

ATOM 14645 CA GLN D 90 40. ,335 -38. 627 -62. 714 1. 00 25. ,59 D c

ATOM 14647 CB GLN D 90 40. ,830 -37. 174 -62. 689 1. 00 26. ,82 D c

ATOM 14650 CG GLN D 90 41. ,095 -36. 496 -63. 935 1. 00 29. ,48 D c

ATOM 14653 CD GLN D 90 42. ,328 -36. 969 -64. 655 1. 00 19. ,89 D c

ATOM 14654 OEl GLN D 90 43. ,474 -36. 844 -64. 208 1. 00 26. ,78 D 0

ATOM 14655 NE2 GLN D 90 42. ,092 -37. ,456 -65. 823 1. 00 24. ,69 D N

ATOM 14658 C GLN D 90 41. ,255 -39. 564 -63. 511 1. 00 24. ,41 D c

ATOM 14659 0 GLN D 90 42. ,419 -39. 669 -63. 176 1. 00 24. ,58 D 0

ATOM 14661 N SER D 91 40. ,746 -40. 218 -64. 563 1. 00 25. ,09 D N

ATOM 14662 CA SER D 91 41. ,561 -41. 085 -65. 433 1. 00 23. ,75 D c

ATOM 14664 CB SER D 91 41. ,324 -42. 564 -65. 110 1. 00 28. ,68 D c

ATOM 14667 OG SER D 91 39. ,952 -42. 888 -65. 101 1. 00 27. ,41 D 0

ATOM 14669 C SER D 91 41. ,404 -40. 835 -66. 948 1. 00 22. ,49 D c

ATOM 14670 0 SER D 91 41.363 -41. 746 -67. 769 1. 00 23. ,99 D 0

ATOM 14672 N ASP D 92 41. ,353 -39. 570 -67. 293 1. 00 23. ,36 D N

ATOM 14673 CA ASP D 92 41.367 -39. ,088 -68. 670 1. 00 22. ,56 D c

ATOM 14675 CB ASP D 92 41. ,155 -37. 570 -68. 634 1. 00 25. ,39 D C

ATOM 14678 CG ASP D 92 41. ,245 -36. 942 -69. 976 1. 00 26. .61 D C

ATOM 14679 ODl ASP D 92 40. ,226 -36. 906 -70. 683 1. 00 27. ,79 D 0

ATOM 14680 002 ASP D 92 42. ,336 -36. 460 -70. 300 1. 00 28. ,44 D 0

ATOM 14681 C ASP D 92 42. ,666 -39. 402 -69. 406 1. 00 24. ,59 D C

ATOM 14682 0 ASP D 92 42. ,645 -39. 776 -70. 589 1. 00 20. ,40 D 0

ATOM 14684 N SER D 93 43. 783 -39. 256 -68. 694 1. 00 22. ,26 D N

ATOM 14685 CA SER D 93 45. ,122 -39. 366 -69. 279 1. 00 23. ,17 D C

ATOM 14687 CB SER D 93 45. ,437 -38. 103 -70. 076 1. 00 24. ,63 D C

ATOM 14690 OG SER D 93 45. ,139 -36. ,940 -69. 309 1. 00 17. .68 D 0

ATOM 14692 C SER D 93 46. ,145 -39. ,553 -68. 173 1. 00 22. ,37 D c

ATOM 14693 0 SER D 93 45. ,819 -39. ,409 -67. 010 1. 00 18. ,71 D 0

ATOM 14695 N LEU D 94 47. ,385 -39. ,889 -68. 530 1. 00 25. ,40 D N

ATOM 14696 CA LEU D 94 48. ,458 -39. ,933 -67. 541 1. 00 25. ,92 D C

ATOM 14698 CB LEU D 94 49. ,565 -40. ,908 -67. 945 1. 00 22. ,65 D C

ATOM 14701 CG LEU D 94 49. ,144 -42. ,378 -67. 965 1. 00 27. ,95 D C

ATOM 14703 CDl LEU D 94 50. ,213 -43. ,176 -68. 669 1. 00 24. ,33 D c

ATOM 14707 CD2 LEU D 94 48. 849 -42. ,925 -66. 544 1. 00 25. ,24 D c

ATOM 14711 C LEU D 94 49. ,033 -38. 535 -67. 440 1. 00 24. ,84 D c

ATOM 14712 0 LEU D 94 49. ,247 -37. ,898 -68. 469 1. 00 30, .22 D 0

ATOM 14714 N PRO D 95 49. ,311 -38. ,054 -66. 207 1. 00 17. .81 D N

ATOM 14715 CA PRO D 95 49. ,148 -38. 694 -64. 908 1. 00 17, .93 D c

ATOM 14717 CB PRO D 95 50. ,081 -37. ,877 -64. 021 1. 00 18. .50 D c

ATOM 14720 CG PRO D 95 50. ,003 -36. 559 -64. 560 1. 00 18. .07 D c

ATOM 14723 CD PRO D 95 49. ,848 -36. 700 -66. 048 1. 00 18. ,43 D c

ATOM 14726 C PRO D 95 47. ,717 -38. 576 -64. 393 1. 00 17. ,72 D c

ATOM 14727 0 PRO D 95 47. ,064 -37. 578 -64. 666 1. 00 16. ,78 D 0

ATOM 14728 N TYR D 96 47. ,228 -39. ,594 -63. 693 1. 00 23. ,06 D N

ATOM 14729 CA TYR D 96 45. ,895 -39. ,541 -63. 081 1. 00 14. ,78 D c

ATOM 14731 CB TYR D 96 45. ,442 -40. ,921 -62. 612 1. 00 16, ,14 D c

ATOM 14734 CG TYR D 96 45. ,245 -42. ,001 -63. 661 1. 00 17, ,13 D c

ATOM 14735 CDl TYR D 96 45. ,156 -41. ,691 -65. 020 1. 00 17, .38 D c

ATOM 14737 CEl TYR D 96 44. ,941 -42. ,645 -65. 937 1. 00 15, .77 D c

ATOM 14739 CZ TYR D 96 44. ,790 -43. ,951 -65. 541 1. 00 17, ,77 D c

ATOM 14740 OH TYR D 96 44. ,553 -44. ,887 -66. 492 1. 00 17, .87 D 0

ATOM 14742 CE2 TYR D 96 44. ,841 -44. 308 -64. 200 1. 00 15, ,05 D c

ATOM 14744 CD2 TYR D 96 45. ,090 -43. 329 -63. 278 1. 00 15. .05 D c

ATOM 14746 C TYR D 96 45. ,960 -38. ,617 -61. 871 1. 00 21. ,05 D c

ATOM 14747 0 TYR D 96 47. ,041 -38. ,251 -61. 435 1. 00 16. ,87 D 0 cyno fD_Fab

ATOM 14749 N THR D 97 44. .794 -38. ,255 -61. ,315 1.00 22. 41 D N

ATOM 14750 CA THR D 97 44. ,727 -37. ,339 -60. 182 1.00 19. 27 D C

ATOM 14752 CB THR D 97 44. ,372 -35. 849 -60. ,564 1.00 23. 55 D C

ATOM 14754 OGl THR D 97 45. ,007 -35. 462 -61. 789 1.00 19. 90 D 0

ATOM 14756 CG2 THR D 97 44. ,749 -34. 866 -59. ,416 1.00 18. 47 D C

ATOM 14760 C THR D 97 43. ,612 -37. 800 -59. 262 1.00 20. 18 D c

ATOM 14761 0 THR D 97 42. ,496 -37. 968 -59. ,714 1.00 18. 25 D 0

ATOM 14763 N PHE D 98 43. ,941 -37. 946 -57. 978 1.00 17. 72 D N

ATOM 14764 CA PHE D 98 42. ,975 -38. ,130 -56. ,931 1.00 19. 02 D c

ATOM 14766 CB PHE D 98 43. ,628 -38. 810 -55. ,733 1.00 16. 64 D c

ATOM 14769 CG PHE D 98 43. ,751 -40. 308 -55. ,830 1.00 16. 93 D c

ATOM 14770 CDl PHE D 98 42. ,640 -41. 125 -55. ,674 1.00 16. 30 D c

ATOM 14772 CEl PHE D 98 42. ,732 -42. 493 -55. ,713 1.00 15. 69 D c

ATOM 14774 CZ PHE D 98 43. ,973 -43. 088 -55. ,887 1.00 16. 00 D c

ATOM 14776 CE2 PHE D 98 45. ,112 -42. 288 -55. ,993 1.00 16. 64 D c

ATOM 14778 CD2 PHE D 98 44. ,996 -40. 899 -55. ,969 1.00 15. 33 D c

ATOM 14780 C PHE D 98 42. ,504 -36. 759 -56. ,450 1.00 23. 22 D c

ATOM 14781 0 PHE D 98 43. ,284 -35. 823 -56. ,404 1.00 24. 78 D 0

ATOM 14783 N GLY D 99 41. ,241 -36. 646 -56. 062 1.00 25. 63 D N

ATOM 14784 CA GLY D 99 40. ,803 -35. 504 -55. ,284 1.00 22. 02 D c

ATOM 14787 C GLY D 99 41. ,242 -35. 574 -53. ,819 1.00 19. 87 D c

ATOM 14788 0 GLY D 99 41. ,809 -36. 564 -53. ,371 1.00 24. 13 D 0

ATOM 14790 N GLN D 100 40. ,930 -34. 521 -53. ,067 1.00 17. 76 D N

ATOM 14791 CA GLN D 100 41. ,467 -34. 303 -51.729 1.00 20. 61 D c

ATOM 14793 CB GLN D 100 41.405 -32. 826 -51. ,364 1.00 20. 81 D c

ATOM 14796 CG GLN D 100 42. 122 -31. 883 -52. ,348 1.00 25. 98 D c

ATOM 14799 CD GLN D 100 41.378 -31. 633 -53. ,674 1.00 26. 07 D c

ATOM 14800 OEl GLN D 100 40. 359 -32. 252 -53. ,982 1.00 32. 19 D 0

ATOM 14801 NE2 GLN D 100 41. ,892 -30. 707 -54. ,448 1.00 31. 10 D N

ATOM 14804 C GLN D 100 40. ,751 -35. 143 -50. ,679 1.00 16. 02 D c

ATOM 14805 0 GLN D 100 41. 194 -35. 251 -49. ,539 1.00 21. 53 D 0

ATOM 14807 N GLY D 101 39. ,640 -35. 743 -51. ,073 1.00 23. 63 D N

ATOM 14808 CA GLY D 101 38. ,920 -36. 670 -50. 215 1.00 24. 16 D c

ATOM 14811 C GLY D 101 37. ,772 -35. 988 -49. ,498 1.00 19. 70 D c

ATOM 14812 0 GLY D 101 37. ,788 -34. 777 -49. ,312 1.00 23. 12 D 0

ATOM 14814 N THR D 102 36. ,789 -36. 803 -49. ,110 1.00 23. 12 D N

ATOM 14815 CA THR D 102 35. 608 -36. 385 -48. ,339 1.00 19. 43 D c

ATOM 14817 CB THR D 102 34. ,339 -36. 243 -49. ,202 1.00 20. 17 D c

ATOM 14819 OGl THR D 102 34. 567 -35. 342 -50. ,290 1.00 22. 19 D 0

ATOM 14821 CG2 THR D 102 33. ,177 -35. 711 -48. ,365 1.00 16. 57 D c

ATOM 14825 C THR D 102 35. ,319 -37. 430 -47. ,262 1.00 20. 19 D c

ATOM 14826 0 THR D 102 35. ,013 -38. 592 -47. ,551 1.00 18. 78 D 0

ATOM 14828 N LYS D 103 35. ,445 -37. 028 -46. ,012 1.00 19. 52 D N

ATOM 14829 CA LYS D 103 35. ,133 -37. 910 -44. ,908 1.00 21. 81 D c

ATOM 14831 CB LYS D 103 35. ,896 -37. 453 -43. ,664 1.00 22. 97 D c

ATOM 14834 CG LYS D 103 35. ,842 -38. 453 -42. ,523 1.00 24. 14 D c

ATOM 14837 CD LYS D 103 35. ,941 -37. ,747 -41. ,171 1.00 29. 39 D c

ATOM 14840 CE LYS D 103 37. ,302 -37. 845 -40. ,569 1.00 36. 08 D c

ATOM 14843 NZ LYS D 103 37. ,363 -39. ,041 -39. ,724 1.00 37. 15 D N

ATOM 14847 C LYS D 103 33. ,634 -37. 882 -44. ,624 1.00 22. 14 D c

ATOM 14848 0 LYS D 103 33. ,098 -36. 848 -44. ,257 1.00 21. 42 D 0

ATOM 14850 N VAL D 104 32. ,974 -39. 027 -44. 792 1.00 26. 54 D N

ATOM 14851 CA VAL D 104 31.551 -39. 170 -44. ,521 1.00 23. 50 D c

ATOM 14853 CB VAL D 104 30. ,876 -40. 053 -45. 569 1.00 22. 74 D c

ATOM 14855 CGl VAL D 104 29. ,409 -40. 285 -45. 188 1.00 24. 14 D c

ATOM 14859 CG2 VAL D 104 31. ,004 -39. 421 -46. 967 1.00 18. 29 D c

ATOM 14863 C VAL D 104 31. ,331 -39. 766 -43. 130 1.00 29. 41 D c

ATOM 14864 0 VAL D 104 31. ,807 -40. 861 -42. 856 1.00 28. 82 D 0

ATOM 14866 N GLU D 105 30. ,595 -39. ,045 -42. ,276 1.00 28. 13 D N

ATOM 14867 CA GLU D 105 30. ,346 -39. ,448 -40. ,893 1.00 28. 64 D c

ATOM 14869 CB GLU D 105 30. ,939 -38. ,421 -39. ,928 1.00 31. ,57 D C

ATOM 14872 CG GLU D 105 32. ,398 -38. ,055 -40. ,236 1.00 35. ,47 D c

ATOM 14875 CD GLU D 105 33. ,176 -37. 619 -39. ,002 1.00 37. ,71 D c

ATOM 14876 OEl GLU D 105 33. ,318 -36. 392 -38. ,799 1.00 41. 28 D 0

ATOM 14877 OE2 GLU D 105 33. ,634 -38. 506 -38. ,235 1.00 37. 76 D 0

ATOM 14878 C GLU D 105 28. ,849 -39. 604 -40. ,621 1.00 25. 14 D c

ATOM 14879 0 GLU D 105 28. ,021 -39. 041 -41. ,310 1.00 21. ,64 D 0

ATOM 14881 N ILE D 106 28. ,490 -40. ,398 -39. ,626 1.00 32. 36 D N cyno fD_Fab

ATOM 14882 CA ILE D 106 27. .072 -40. .610 -39. 333 1. 00 29. ,59 D C

ATOM 14884 CB ILE D 106 26. .686 -42. ,098 -39. 205 1. 00 27. ,88 D C

ATOM 14886 CGI ILE D 106 26.529 -42. ,705 -40. 585 1. 00 24. ,47 D C

ATOM 14889 CDl ILE D 106 25. .983 -44. ,058 -40. 566 1. 00 24. ,61 D C

ATOM 14893 CG2 ILE D 106 25. ,366 -42. ,267 -38. 449 1. 00 28. ,17 D C

ATOM 14897 C ILE D 106 26. ,697 -39. ,879 -38. 087 1. 00 31. ,86 D c

ATOM 14898 O ILE D 106 27. ,394 -39. ,958 -37. 078 1. 00 35. ,56 D 0

ATOM 14900 N LYS D 107 25. ,588 -39. ,154 -38. 177 1. 00 35. ,20 D N

ATOM 14901 CA LYS D 107 24. ,985 -38. ,536 -37. 017 1. 00 34. ,44 D c

ATOM 14903 CB LYS D 107 24. ,512 -37. ,111 -37. 325 1. 00 37. ,48 D c

ATOM 14906 CG LYS D 107 23. ,017 -36. ,868 -37. 381 1. 00 43. ,55 D c

ATOM 14909 CD LYS D 107 22. ,540 -36. ,073 -36. 181 1. 00 46. 00 D c

ATOM 14912 CE LYS D 107 22. ,850 -34. ,594 -36. 358 1. 00 47. ,73 D c

ATOM 14915 NZ LYS D 107 22. ,653 -33. ,837 -35. 091 1. 00 47. 52 D N

ATOM 14919 C LYS D 107 23. ,879 -39. ,471 -36. 542 1. 00 33. ,34 D c

ATOM 14920 O LYS D 107 23. ,188 -40. ,118 -37. 328 1. 00 35. 03 D 0

ATOM 14922 N ARG D 108 23. ,732 -39. ,527 -35. 233 1. 00 33. 03 D N

ATOM 14923 CA ARG D 108 23. ,187 -40. ,680 -34. 569 1. 00 31. ,01 D c

ATOM 14925 CB ARG D 108 24. ,305 -41. ,714 -34. 538 1. 00 32. ,10 D c

ATOM 14928 CG ARG D 108 24. 050 -42. ,977 -33. 803 1. 00 37. 21 D c

ATOM 14931 CD ARG D 108 24. ,979 -43. ,109 -32. 625 1. 00 39. 14 D c

ATOM 14934 NE ARG D 108 24. ,977 -44. ,485 -32. 170 1. 00 43. 01 D N

ATOM 14936 CZ ARG D 108 24. ,055 -45. ,038 -31. 387 1. 00 41. ,52 D c

ATOM 14937 NHl ARG D 108 23. ,043 -44. ,335 -30. 905 1. 00 42. ,43 D N

ATOM 14940 NH2 ARG D 108 24. ,174 -46. ,318 -31. 067 1. 00 45. 02 D N

ATOM 14943 C ARG D 108 22. ,758 -40. ,199 -33. 187 1. 00 29. ,58 D C

ATOM 14944 0 ARG D 108 23. ,211 -39. ,147 -32. 737 1. 00 30. ,07 D 0

ATOM 14946 N THR D 109 21. ,856 -40, ,926 -32. 538 1. 00 31. ,51 D N

ATOM 14947 CA THR D 109 21. ,395 -40. ,566 -31. 189 1. 00 31. ,58 D C

ATOM 14949 CB THR D 109 20. ,217 -41. ,476 -30. 704 1. 00 31. ,60 D C

ATOM 14951 OGl THR D 109 20. ,539 -42. ,856 -30. 914 1. 00 33. ,30 D 0

ATOM 14953 CG2 THR D 109 18. ,946 -41. ,169 -31.459 1. 00 25. ,01 D C

ATOM 14957 C THR D 109 22. ,533 -40. ,637 -30. 180 1. 00 31. 79 D c

ATOM 14958 0 THR D 109 23. ,572 -41. ,235 -30. 445 1. 00 35. ,81 D 0

ATOM 14960 N VAL D 110 22, ,327 -40. ,029 -29. 018 1. 00 31. ,94 D N

ATOM 14961 CA VAL D 110 23. ,354 -39. ,981 -27. 985 1. 00 33. ,09 D c

ATOM 14963 CB VAL D 110 23. ,073 -38. ,850 -26. 964 1. 00 33. ,06 D c

ATOM 14965 CGl VAL D 110 23. ,279 -37. ,504 -27. 623 1. 00 35. ,90 D c

ATOM 14969 CG2 VAL D 110 23. ,982 -38. ,958 -25. 784 1. 00 32. ,84 D c

ATOM 14973 C VAL D 110 23. ,501 -41. ,323 -27. 258 1. 00 35. ,00 D c

ATOM 14974 0 VAL D 110 22. 512 -41.960 -26. 892 1. 00 35. ,42 D 0

ATOM 14976 N ALA D 111 24. 748 -41. ,749 -27. 076 1. 00 33. ,63 D N

ATOM 14977 CA ALA D 111 25. 062 -42. ,979 -26. 373 1. 00 30. ,52 D c

ATOM 14979 CB ALA D 111 25. ,590 -44. ,016 -27. 330 1. 00 28. ,06 D c

ATOM 14983 C ALA D 111 26. ,096 -42. ,674 -25. 301 1. 00 32. ,32 D c

ATOM 14984 0 ALA D 111 27. ,192 -42, .189 -25. 605 1. 00 34. ,60 D 0

ATOM 14986 N ALA D 112 25. ,739 -42, .937 -24. 046 1. 00 29. ,23 D N

ATOM 14987 CA ALA D 112 26. ,682 -42, .814 -22. 940 1. 00 29. ,88 D c

ATOM 14989 CB ALA D 112 25. ,966 -42, .934 -21. ,606 1. 00 25. ,30 D c

ATOM 14993 C ALA D 112 27. ,714 -43, .921 -23. 084 1. 00 29. ,74 D c

ATOM 14994 0 ALA D 112 27. ,378 -45, .018 -23. 538 1. 00 32. ,65 D 0

ATOM 14996 N PRO D 113 28. ,982 -43. .634 -22. 748 1. 00 27. ,72 D N

ATOM 14997 CA PRO D 113 29. ,965 -44. .707 -22. 751 1. 00 27. ,32 D c

ATOM 14999 CB PRO D 113 31. ,295 -43. .963 -22. 645 1. 00 26. ,69 D c

ATOM 15002 CG PRO D 113 30. ,964 -42. ,689 -21. 969 1. 00 26. ,88 D c

ATOM 15005 CD PRO D 113 29. ,578 -42. ,336 -22. 393 1. 00 26. ,25 D c

ATOM 15008 C PRO D 113 29. ,788 -45. ,625 -21. 557 1. 00 29. ,97 D c

ATOM 15009 0 PRO D 113 29. ,350 -45, .177 -20. ,500 1. 00 30. ,27 D 0

ATOM 15010 N SER D 114 30. ,104 -46, .905 -21. 746 1. 00 31.38 D N

ATOM 15011 CA SER D 114 30. ,398 -47, .809 -20. ,637 1. 00 28. ,44 D c

ATOM 15013 CB SER D 114 30. ,195 -49, .271 -21. 047 1. 00 31, ,00 D c

ATOM 15016 OG SER D 114 29. ,261 -49, .396 -22. 110 1. 00 37, ,75 D 0

ATOM 15018 C SER D 114 31. ,865 -47, .563 -20. 277 1. 00 28. ,88 D c

ATOM 15019 0 SER D 114 32. ,692 -47, .392 -21. 168 1. 00 29. ,06 D 0

ATOM 15021 N VAL D 115 32. ,193 -47, .528 -18. ,985 1. 00 30. ,10 D N

ATOM 15022 CA VAL D 115 33. ,564 -47, .210 -18. 565 1. 00 29, ,12 D c

ATOM 15024 CB VAL D 115 33. ,630 -45, .911 -17. 744 1. 00 26. ,46 D c

ATOM 15026 CGl VAL D 115 35. ,053 -45, .662 -17. 241 1. 00 21. ,50 D c cyno fD_Fab

ATOM 15030 CG2 VAL D 115 33. ,147 -44, ,738 -18. ,586 1. 00 21. ,91 D C

ATOM 15034 C VAL D 115 34. ,182 -48. ,351 -17. ,767 1. 00 29. ,14 D C

ATOM 15035 O VAL D 115 33. ,528 -48. ,933 -16. ,917 1. 00 25. ,04 D 0

ATOM 15037 N PHE D 116 35. ,441 -48. ,660 -18. ,086 1. 00 31. 23 D N

ATOM 15038 CA PHE D 116 36. ,198 -49. ,741 -17. ,466 1. 00 29. 75 D C

ATOM 15040 CB PHE D 116 36. ,376 -50. 917 -18. ,439 1. 00 33. 06 D C

ATOM 15043 CG PHE D 116 35. 086 -51. ,458 -19. ,011 1. 00 34. 46 D C

ATOM 15044 CDl PHE D 116 34. 391 -52. ,475 -18. ,366 1. 00 35. 78 D c

ATOM 15046 CEl PHE D 116 33. ,213 -52. ,983 -18. ,905 1. 00 33. ,55 D c

ATOM 15048 CZ PHE D 116 32. ,730 -52. ,485 -20. ,093 1. 00 33. 99 D c

ATOM 15050 CE2 PHE D 116 33. ,413 -51. ,481 -20. ,750 1. 00 33. ,27 D c

ATOM 15052 CD2 PHE D 116 34. 589 -50. ,976 -20. ,214 1. 00 32. ,96 D c

ATOM 15054 C PHE D 116 37. ,584 -49. ,231 -17. ,100 1. 00 27. 39 D c

ATOM 15055 O PHE D 116 38. 196 -48. ,490 -17. ,865 1. 00 24. 57 D 0

ATOM 15057 N ILE D 117 38. 091 -49. ,657 -15. ,945 1. 00 30. 76 D N

ATOM 15058 CA ILE D 117 39. 436 -49. ,291 -15. ,511 1. 00 28. 81 D c

ATOM 15060 CB ILE D 117 39. 388 -48. ,460 -14. ,191 1. 00 30. 10 D c

ATOM 15062 CGI ILE D 117 40. 780 -47. ,918 -13. ,834 1. 00 28. 19 D c

ATOM 15065 CDl ILE D 117 40. ,759 -46. ,847 -12. ,775 1. 00 26. ,00 D c

ATOM 15069 CG2 ILE D 117 38. 784 -49. ,277 -13. ,057 1. 00 25. ,02 D c

ATOM 15073 C ILE D 117 40. 282 -50. ,564 -15. ,378 1. 00 29. ,40 D c

ATOM 15074 O ILE D 117 39. ,769 -51.614 -14. .988 1. 00 27. ,02 D 0

ATOM 15076 N PHE D 118 41. 563 -50. ,464 -15. ,745 1. 00 31. 05 D N

ATOM 15077 CA PHE D 118 42. 510 -51.581 -15. ,691 1. 00 29. 55 D c

ATOM 15079 CB PHE D 118 42. 968 -51. ,996 -17. ,089 1. 00 30. 50 D c

ATOM 15082 CG PHE D 118 41. 879 -52. ,537 -17. ,950 1. 00 30. 95 D c

ATOM 15083 CDl PHE D 118 41. 530 -53. ,875 -17. ,879 1. 00 29. 74 D c

ATOM 15085 CEl PHE D 118 40. 530 -54. ,384 -18. ,674 1. 00 30. 56 D c

ATOM 15087 CZ PHE D 118 39. ,861 -53. ,558 -19. ,546 1. 00 30. ,88 D c

ATOM 15089 CE2 PHE D 118 40. ,197 -52. ,211 -19. ,624 1. 00 30. 79 D c

ATOM 15091 CD2 PHE D 118 41. ,206 -51. ,711 -18. ,835 1. 00 30. ,33 D c

ATOM 15093 C PHE D 118 43. ,756 -51. ,178 -14. ,937 1. 00 29. ,55 D c

ATOM 15094 0 PHE D 118 44. ,518 -50. ,350 -15. ,426 1. 00 31. ,14 D 0

ATOM 15096 N PRO D 119 43. 999 -51. ,786 -13. ,765 1. 00 28. 66 D N

ATOM 15097 CA PRO D 119 45. 267 -51.525 -13. ,095 1. 00 29. 35 D c

ATOM 15099 CB PRO D 119 45. 169 -52. ,344 -11.804 1. 00 29. 92 D c

ATOM 15102 CG PRO D 119 43. 726 -52. ,651 -11. ,632 1. 00 31. 03 D c

ATOM 15105 CD PRO D 119 43. 140 -52. ,701 -12. ,997 1. 00 29. 98 D c

ATOM 15108 C PRO D 119 46. ,440 -52. ,007 -13. ,930 1. 00 27. ,14 D c

ATOM 15109 0 PRO D 119 46. ,240 -52. ,749 -14. ,883 1. 00 25. 56 D 0

ATOM 15110 N PRO D 120 47. ,667 -51. ,622 -13. ,554 1. 00 29. 13 D N

ATOM 15111 CA PRO D 120 48. ,806 -52. ,126 -14. ,300 1. 00 30. ,79 D c

ATOM 15113 CB PRO D 120 50. ,003 -51. ,384 -13. ,691 1. 00 27. ,20 D c

ATOM 15116 CG PRO D 120 49. ,442 -50. 309 -12. ,896 1. 00 29. 10 D c

ATOM 15119 CD PRO D 120 48. ,090 -50. 759 -12. ,448 1. 00 29. ,73 D c

ATOM 15122 C PRO D 120 48. ,976 -53. 621 -14, ,118 1. 00 33. ,17 D c

ATOM 15123 0 PRO D 120 48. 596 -54. ,180 -13. ,080 1. 00 33. ,53 D 0

ATOM 15124 N SER D 121 49. 540 -54. ,252 -15. ,139 1. 00 34. 61 D N

ATOM 15125 CA SER D 121 49. ,883 -55. ,661 -15. .093 1. 00 36. ,58 D c

ATOM 15127 CB SER D 121 50. ,432 -56. ,085 -16. .450 1. 00 34. ,74 D c

ATOM 15130 OG SER D 121 50. ,750 -57. ,452 -16. .452 1. 00 38. ,70 D 0

ATOM 15132 C SER D 121 50. 931 -55. ,924 -14. .010 1. 00 38. ,64 D c

ATOM 15133 0 SER D 121 51. ,852 -55. ,122 -13. ,821 1. 00 37. ,91 D 0

ATOM 15135 N ASP D 122 50. 802 -57. ,046 -13. ,305 1. 00 39. ,96 D N

ATOM 15136 CA ASP D 122 51. 814 -57. ,423 -12. ,327 1. 00 40. ,89 D c

ATOM 15138 CB ASP D 122 51. ,420 -58. ,700 -11. ,564 1. 00 46. ,16 D c

ATOM 15141 CG ASP D 122 50. ,536 -58. ,421 -10. ,338 1. 00 48. ,41 D c

ATOM 15142 ODl ASP D 122 50. ,770 -57. ,421 -9. ,621 1. 00 46. ,39 D 0

ATOM 15143 OD2 ASP D 122 49. ,613 -59. ,225 -10. .084 1. 00 50. ,90 D 0

ATOM 15144 C ASP D 122 53. ,143 -57. ,604 -13, .057 1. 00 39. ,97 D c

ATOM 15145 0 ASP D 122 54. 201 -57. ,233 -12, .549 1. 00 39. ,70 D 0

ATOM 15147 N GLU D 123 53. ,075 -58. ,150 -14. .265 1. 00 40. ,92 D N

ATOM 15148 CA GLU D 123 54. ,254 -58. ,304 -15. .106 1. 00 41. ,52 D c

ATOM 15150 CB GLU D 123 53. ,874 -58. ,981 -16. ,414 1. 00 41. ,20 D c

ATOM 15153 CG GLU D 123 55. ,073 -59. ,428 -17. .223 1. 00 43. ,54 D c

ATOM 15156 CD GLU D 123 54. ,680 -60. ,002 -18. .564 1. 00 48. ,16 D c

ATOM 15157 OE1 GLU D 123 53. ,464 -60. ,049 -18. ,866 1. 00 51. ,94 D 0

ATOM 15158 OE2 GLU D 123 55. ,593 -60. ,400 -19. ,319 1. 00 52. ,58 D 0 cyno fD_Fab

ATOM 15159 C GLU D 123 54. ,933 -56. ,973 -15. 418 1. 00 41.78 D C

ATOM 15160 O GLU D 123 56. ,163 -56. ,902 -15. 475 1. 00 41. ,61 D 0

ATOM 15162 N GLN D 124 54. ,126 -55. ,931 -15. 639 1. 00 41.22 D N

ATOM 15163 CA GLN D 124 54. .637 -54. ,613 -16. 020 1. 00 39. ,06 D C

ATOM 15165 CB GLN D 124 53. ,523 -53. ,710 -16. ,564 1. 00 36. ,82 D c

ATOM 15168 CG GLN D 124 54. ,082 -52. ,438 -17. 204 1. 00 37. ,60 D c

ATOM 15171 CD GLN D 124 53. ,044 -51. ,384 -17. 552 1. 00 33. ,82 D c

ATOM 15172 OEl GLN D 124 51. ,851 -51. ,530 -17. 276 1. 00 29. 25 D 0

ATOM 15173 NE2 GLN D 124 53. ,507 -50. ,304 -18. 169 1. 00 33. 21 D N

ATOM 15176 C GLN D 124 55. ,350 -53. ,912 -14. 865 1. 00 39. ,73 D c

ATOM 15177 O GLN D 124 56. ,408 -53. ,311 -15. ,072 1. 00 38. ,43 D 0

ATOM 15179 N LEU D 125 54. ,764 -53. ,965 -13. 666 1. 00 41.44 D N

ATOM 15180 CA LEU D 125 55. ,404 -53. ,410 -12. 463 1. 00 42. .32 D c

ATOM 15182 CB LEU D 125 54, ,605 -53. ,747 -11. 198 1. 00 37. ,58 D c

ATOM 15185 CG LEU D 125 53. ,410 -52. ,905 -10. 742 1. 00 33. 02 D c

ATOM 15187 CDl LEU D 125 53. ,620 -51. ,428 -11. 052 1. 00 31.93 D c

ATOM 15191 CD2 LEU D 125 52. ,118 -53. ,421 -11. 324 1. 00 31. ,83 D c

ATOM 15195 C LEU D 125 56. ,826 -53. ,957 -12. 317 1. 00 44. ,07 D c

ATOM 15196 0 LEU D 125 57. ,767 -53. ,210 -12. 043 1. 00 44. ,84 D 0

ATOM 15198 N LYS D 126 56. ,954 -55. ,267 -12. 508 1. 00 46. ,83 D N

ATOM 15199 CA LYS D 126 58. ,245 -55. ,968 -12. 542 1. 00 50. ,83 D C

ATOM 15201 CB LYS D 126 58. ,040 -57. ,354 -13. ,177 1. 00 54. ,90 D C

ATOM 15204 CG LYS D 126 58. ,628 -58. ,538 -12. 421 1. 00 56. ,24 D c

ATOM 15207 CD LYS D 126 57, ,774 -59. ,791 -12. 673 1. 00 56. ,17 D c

ATOM 15210 CE LYS D 126 58. ,559 -61. ,079 -12. 507 1. 00 57. ,56 D c

ATOM 15213 NZ LYS D 126 59. ,624 -61.239 -13. 537 1. 00 59. ,31 D N

ATOM 15217 C LYS D 126 59. ,326 -55. ,195 -13. 322 1. 00 52. ,15 D c

ATOM 15218 0 LYS D 126 60. 465 -55. ,081 -12. 859 1. 00 53. ,19 D 0

ATOM 15220 N SER D 127 58. ,959 -54. ,672 -14. ,497 1. 00 50. ,79 D N

ATOM 15221 CA SER D 127 59. .883 -53. ,908 -15. ,353 1. 00 48. ,68 D C

ATOM 15223 CB SER D 127 59. ,476 -54. ,031 -16. ,832 1. 00 50. ,68 D C

ATOM 15226 OG SER D 127 58. ,198 -53. ,463 -17. ,091 1. 00 49. ,93 D 0

ATOM 15228 C SER D 127 60. ,026 -52. ,422 -14. ,954 1. 00 47. ,27 D C

ATOM 15229 0 SER D 127 60. .800 -51. ,690 -15. 574 1. 00 46. ,30 D 0

ATOM 15231 N GLY D 128 59. ,278 -51. ,983 -13. 939 1. 00 45. ,20 D N

ATOM 15232 CA GLY D 128 59. ,483 -50. ,670 -13. 316 1. 00 44. ,46 D c

ATOM 15235 C GLY D 128 58. ,550 -49. ,533 -13. 719 1. 00 44. ,32 D c

ATOM 15236 0 GLY D 128 58. ,847 -48. .372 -13. ,425 1. 00 44. ,67 D 0

ATOM 15238 N THR D 129 57. ,425 -49. ,852 -14. ,366 1. 00 42. ,57 D N

ATOM 15239 CA THR D 129 56. ,453 -48. ,836 -14. ,823 1. 00 40. ,41 D c

ATOM 15241 CB THR D 129 56. ,625 -48. ,522 -16. ,331 1. 00 41, ,75 D c

ATOM 15243 OGl THR D 129 58. ,008 -48. ,301 -16. 622 1. 00 44. ,53 D 0

ATOM 15245 CG2 THR D 129 55. ,819 -47. ,282 -16. ,734 1. 00 41. ,17 D c

ATOM 15249 C THR D 129 55. ,003 -49. ,281 -14. ,592 1. 00 37. ,87 D c

ATOM 15250 0 THR D 129 54. ,674 -50. ,458 -14. ,738 1. 00 35. ,71 D 0

ATOM 15252 N ALA D 130 54. ,143 -48. ,325 -14. ,242 1. 00 36. ,71 D N

ATOM 15253 CA ALA D 130 52, .703 -48, .565 -14. ,087 1. 00 34. ,74 D c

ATOM 15255 CB ALA D 130 52. .246 -48, .110 -12. ,707 1. 00 33. ,49 D c

ATOM 15259 C ALA D 130 51. .903 -47. .837 -15. ,179 1. 00 34. ,70 D c

ATOM 15260 0 ALA D 130 51. .999 -46. .615 -15. ,321 1. 00 34. ,83 D 0

ATOM 15262 N SER D 131 51. ,131 -48. .593 -15. 960 1. 00 31. ,77 D N

ATOM 15263 CA SER D 131 50. ,190 -48. .020 -16. 902 1. 00 28. ,49 D c

ATOM 15265 CB SER D 131 50. ,479 -48. ,516 -18. 310 1. 00 28. ,78 D c

ATOM 15268 OG SER D 131 51.859 -48. ,361 -18. ,587 1. 00 30. ,26 D 0

ATOM 15270 C SER D 131 48. ,776 -48. ,379 -16. ,470 1. 00 27. ,13 D c

ATOM 15271 0 SER D 131 48, ,406 -49, .548 -16. ,424 1. 00 25, .44 D 0

ATOM 15273 N VAL D 132 47, ,998 -47. .357 -16. ,125 1. 00 26, .88 D N

ATOM 15274 CA VAL D 132 46, .616 -47, .537 -15. ,708 1. 00 26. .00 D c

ATOM 15276 CB VAL D 132 46. .255 -46, .646 -14. ,490 1. 00 20. .58 D c

ATOM 15278 CGI VAL D 132 44. ,985 -47, .142 -13. ,822 1. 00 17. ,41 D c

ATOM 15282 CG2 VAL D 132 47. .415 -46, .583 -13. ,502 1. 00 16. ,64 D c

ATOM 15286 C VAL D 132 45. ,775 -47. .146 -16. ,908 1. 00 25. ,48 D c

ATOM 15287 0 VAL D 132 45. .922 -46. .040 -17. ,428 1. 00 30. ,57 D 0

ATOM 15289 N VAL D 133 44. ,910 -48. .051 -17. ,361 1. 00 25. ,94 D

ATOM 15290 CA VAL D 133 44, .162 -47, .846 -18. ,598 1. 00 27, .27 D c

ATOM 15292 CB VAL D 133 44, .412 -49, .016 -19. ,599 1. 00 26, .21 D c

ATOM 15294 CGI VAL D 133 43, .535 -48, .899 -20. ,842 1. 00 22, .42 D c

ATOM 15298 CG2 VAL D 133 45, .880 -49, .055 -20. ,010 1. 00 24, .94 D c cyno fD_Fab

ATOM 15302 C VAL D 133 42. 666 -47. 632 -18. ,305 1. 00 28. 46 D C

ATOM 15303 O VAL D 133 42. 048 -48. 378 -17. ,543 1. 00 27. 42 D 0

ATOM 15305 N CYS D 134 42. 101 -46. 585 -18. 899 1. 00 31. 94 D N

ATOM 15306 CA CYS D 134 40. 676 -46. 307 -18. ,789 1. 00 31. ,66 D C

ATOM 15308 CB CYS D 134 40. 451 -44. 938 -18. 130 1. 00 34. ,11 D C

ATOM 15311 SG CYS D 134 38. 731 -44. 420 -17. ,972 1. 00 36. ,06 D S

ATOM 15313 C CYS D 134 40. 039 -46. 406 -20. ,183 1. 00 33. 22 D c

ATOM 15314 O CYS D 134 40. 525 -45. ,818 -21. ,151 1. 00 33. 36 D 0

ATOM 15316 N LEU D 135 38. 955 -47. 169 -20. ,274 1. 00 32. ,61 D N

ATOM 15317 CA LEU D 135 38. 301 -47. 450 -21. ,545 1. 00 32. ,21 D c

ATOM 15319 CB LEU D 135 38. 270 -48. 962 -21. ,774 1. 00 31. 24 D c

ATOM 15322 CG LEU D 135 37. 463 -49. 519 -22. ,948 1. 00 32. ,70 D c

ATOM 15324 CDl LEU D 135 37. 919 -48. 937 -24. ,296 1. 00 27. ,46 D c

ATOM 15328 CD2 LEU D 135 37. 584 -51. 039 -22. 928 1. 00 33. ,39 D c

ATOM 15332 C LEU D 135 36. 880 -46. 889 -21. ,566 1. 00 31. ,76 D c

ATOM 15333 0 LEU D 135 36. 059 -47. 242 -20. 721 1. 00 31. ,70 D 0

ATOM 15335 N LEU D 136 36. 603 -46. ,006 -22. ,530 1. 00 33. ,85 D N

ATOM 15336 CA LEU D 136 35. ,239 -45. ,548 -22. ,807 1. 00 30. ,59 D c

ATOM 15338 CB LEU D 136 35. 210 -44. ,041 -23. ,084 1. 00 30. ,02 D c

ATOM 15341 CG LEU D 136 35. 494 -43. 100 -21. ,902 1. 00 29. ,87 D c

ATOM 15343 CDl LEU D 136 36. 729 -43. 532 -21. ,139 1. 00 27. ,59 D c

ATOM 15347 CD2 LEU D 136 35. 647 -41.652 -22. ,366 1. 00 28. ,29 D c

ATOM 15351 C LEU D 136 34. 750 -46. 324 -24. ,017 1. 00 31. ,44 D c

ATOM 15352 0 LEU D 136 35. 324 -46. 204 -25. ,096 1. 00 37. ,86 D 0

ATOM 15354 N ASN D 137 33. 699 -47. 120 -23. ,850 1. 00 32. ,20 D N

ATOM 15355 CA ASN D 137 33. 246 -48. 027 -24. ,916 1. 00 32. ,34 D C

ATOM 15357 CB ASN D 137 33. 100 -49. 459 -24. ,366 1. 00 35. ,12 D C

ATOM 15360 CG ASN D 137 33. 546 -50. ,529 -25. ,360 1. 00 38. ,43 D C

ATOM 15361 001 ASN D 137 34. 679 -50. ,514 -25. ,842 1. 00 42. ,18 D 0

ATOM 15362 ND2 ASN D 137 32. 662 -51. 477 -25. ,649 1. 00 39. ,41 D N

ATOM 15365 C ASN D 137 31. 931 -47. 573 -25. 570 1. 00 30. ,34 D C

ATOM 15366 0 ASN D 137 30. 942 -47. 316 -24. 881 1. 00 27. ,97 D 0

ATOM 15368 N ASN D 138 31. 943 -47. 464 -26. 902 1. 00 29. ,02 D N

ATOM 15369 CA ASN D 138 30. 728 -47. 294 -27. 692 1. 00 28. ,20 D C

ATOM 15371 CB ASN D 138 29. 896 -48. 585 -27. ,677 1. 00 30. ,41 D C

ATOM 15374 CG ASN D 138 30. 694 -49. 824 -28. ,079 1. 00 36. 99 D c

ATOM 15375 ODl ASN D 138 31. 434 -49. 840 -29. 073 1. 00 38. ,74 D 0

ATOM 15376 ND2 ASN D 138 30. 512 -50. 892 -27. 311 1. 00 44. ,52 D N

ATOM 15379 C ASN D 138 29. 836 -46. ,094 -27. ,287 1. 00 27. ,01 D c

ATOM 15380 0 ASN D 138 28. 670 -46. ,266 -26. ,898 1. 00 28. ,24 D 0

ATOM 15382 N PHE D 139 30. 382 -44. ,886 -27. ,410 1. 00 24. ,88 D N

ATOM 15383 CA PHE D 139 29. 644 -43. 653 -27. ,093 1. 00 28. 00 D C

ATOM 15385 CB PHE D 139 30. 340 -42. 878 -25. ,955 1. 00 29. ,11 D C

ATOM 15388 CG PHE D 139 31. 760 -42. 450 -26. 263 1. 00 28. ,78 D c

ATOM 15389 CDl PHE D 139 32. 022 -41. 192 -26. 793 1. 00 28. 17 D c

ATOM 15391 CEl PHE D 139 33. 321 -40. 790 -27. ,075 1. 00 26. ,79 D c

ATOM 15393 CZ PHE D 139 34. 373 -41. ,642 -26. ,819 1. 00 27. 16 D c

ATOM 15395 CE2 PHE D 139 34. 130 -42. ,891 -26. 288 1. 00 26. ,75 D c

ATOM 15397 CD2 PHE D 139 32. 830 -43. 288 -26. ,002 1. 00 27. ,54 D c

ATOM 15399 C PHE D 139 29. 386 -42. ,747 -28. ,306 1. 00 29. ,03 D c

ATOM 15400 0 PHE D 139 30. 031 -42. ,876 -29. ,364 1. 00 31. ,03 D 0

ATOM 15402 N TYR D 140 28. ,394 -41. ,870 -28. ,160 1. 00 29. ,92 D N

ATOM 15403 CA TYR D 140 28. 122 -40. ,821 -29. ,147 1. 00 31. ,12 D c

ATOM 15405 CB TYR D 140 27. 152 -41.299 -30. ,242 1. 00 29. ,92 D c

ATOM 15408 CG TYR D 140 27. 111 -40. 328 -31. ,391 1. 00 30. ,80 D c

ATOM 15409 CDl TYR D 140 28. 010 -40. ,438 -32. ,448 1. 00 24. ,94 D c

ATOM 15411 CEl TYR D 140 28. 007 -39. ,526 -33. ,482 1. 00 31. ,63 D c

ATOM 15413 CZ TYR D 140 27. 103 -38. ,473 -33. ,450 1. 00 31. ,49 D c

ATOM 15414 OH TYR D 140 27. 085 -37. ,546 -34. ,454 1. 00 28. ,96 D 0

ATOM 15416 CE2 TYR D 140 26. 219 -38. ,336 -32. ,400 1. 00 27. ,23 D c

ATOM 15418 CD2 TYR D 140 26. 225 -39. ,255 -31. ,381 1. 00 28. ,73 D c

ATOM 15420 C TYR D 140 27. ,560 -39. ,574 -28. .455 1. 00 34. ,37 D c

ATOM 15421 0 TYR D 140 26. ,641 -39. ,692 -27. ,637 1. 00 34. ,18 D 0

ATOM 15423 N PRO D 141 28. ,074 -38. ,373 -28. ,799 1. 00 34. ,24 D N

ATOM 15424 CA PRO D 141 29. 070 -38. ,051 -29. ,827 1. 00 33. ,63 D c

ATOM 15426 CB PRO D 141 28. 758 -36. ,588 -30. ,171 1. 00 32. ,65 D c

ATOM 15429 CG PRO D 141 28. 106 -36. ,030 -28. ,974 1. 00 32. ,13 D c

ATOM 15432 CD PRO D 141 27. 588 -37. ,157 -28. ,119 1. 00 33. ,61 D c cyno fD_Fab

ATOM 15435 C PRO D 141 30. 547 -38. 224 -29, ,434 1. 00 35. 56 D C

ATOM 15436 O PRO D 141 30. 871 -38. 600 -28, ,318 1. 00 31. 71 D 0

ATOM 15437 N ARG D 142 31. 418 -37. 941 -30, ,394 1. 00 39. 14 D N

ATOM 15438 CA ARG D 142 32. 867 -38. 072 -30. ,264 1. 00 37. 08 D C

ATOM 15440 CB ARG D 142 33. 489 -37. 472 -31, .523 1. 00 41. 30 D c

ATOM 15443 CG ARG D 142 34. 967 -37. 275 -31. ,509 1. 00 46. 19 D c

ATOM 15446 CD ARG D 142 35. 703 -38. 569 -31.413 1. 00 52. 29 D c

ATOM 15449 NE ARG D 142 37. 138 -38. 330 -31. ,526 1. 00 57. 43 D N

ATOM 15451 cz ARG D 142 37. 780 -38. 094 -32. ,670 1. 00 60. 40 D c

ATOM 15452 NHl ARG D 142 37. 120 -38. 073 -33. ,831 1. 00 60. 11 D N

ATOM 15455 NH2 ARG D 142 39. 097 -37. 885 -32. ,653 1. 00 59. 46 D N

ATOM 15458 C ARG D 142 33. 454 -37. 406 -29. ,015 1. 00 37. 18 D c

ATOM 15459 O ARG D 142 34. 409 -37. 904 -28. ,426 1. 00 37. 44 D 0

ATOM 15461 N GLU D 143 32. 871 -36. 280 -28. .624 1. 00 36. 04 D N

ATOM 15462 CA GLU D 143 33. 399 -35. 438 -27. ,558 1. 00 36. 98 D C

ATOM 15464 CB GLU D 143 32. 740 -34. 050 -27. ,607 1. 00 39. 85 D C

ATOM 15467 CG GLU D 143 33. 201 -33. 158 -28. ,776 1. 00 41.92 D C

ATOM 15470 CD GLU D 143 32. 669 -33. 598 -30. ,136 1. 00 43. 37 D c

ATOM 15471 OEl GLU D 143 31. 490 -34. 005 -30. ,210 1. 00 45. 37 D 0

ATOM 15472 OE2 GLU D 143 33. 434 -33. 532 -31. ,131 1. 00 42. 99 D 0

ATOM 15473 C GLU D 143 33. 204 -36. 051 -26. ,160 1. 00 37. 43 D c

ATOM 15474 O GLU D 143 32. 079 -36. 331 -25. ,742 1. 00 37. 88 D 0

ATOM 15476 N ALA D 144 34. 313 -36. 234 -25. ,447 1. 00 34. 18 D N

ATOM 15477 CA ALA D 144 34. 304 -36. 815 -24. .112 1. 00 37. 33 D c

ATOM 15479 CB ALA D 144 34. 262 -38. 339 -24, ,194 1. 00 37. 08 D c

ATOM 15483 C ALA D 144 35. 547 -36. 362 -23. ,365 1. 00 36. 80 D c

ATOM 15484 O ALA D 144 36. 591 -36. 127 -23, ,978 1. 00 37. 64 D 0

ATOM 15486 N LYS D 145 35. 430 -36. 241 -22. ,048 1. 00 37. 39 D N

ATOM 15487 CA LYS D 145 36. 562 -35. 843 -21.211 1. 00 39. 09 D c

ATOM 15489 CB LYS D 145 36. 279 -34. 533 -20. ,481 1. 00 39. 83 D c

ATOM 15492 CG LYS D 145 37. 552 -33. 781 -20. ,115 1. 00 42. 52 D c

ATOM 15495 CD LYS D 145 37. 283 -32. 588 -19. ,203 1. 00 43. 56 D c

ATOM 15498 CE LYS D 145 37. 149 -32. 999 -17. ,750 1. 00 45. 83 D c

ATOM 15501 NZ LYS D 145 36. 957 -31.803 -16. .880 1. 00 43. 85 D N

ATOM 15505 C LYS D 145 36. 894 -36. 933 -20. .205 1. 00 35. 48 D C

ATOM 15506 O LYS D 145 35. 994 -37. 489 -19. .582 1. 00 31. 31 D 0

ATOM 15508 N VAL D 146 38. 188 -37. 237 -20. .089 1. 00 35. 08 D N

ATOM 15509 CA VAL D 146 38. 703 -38. 226 -19. .145 1. 00 36. 58 D C

ATOM 15511 CB VAL D 146 39. 436 -39. 383 -19. ,862 1. 00 35. 47 D c

ATOM 15513 CGl VAL D 146 39. 919 -40. 415 -18. ,854 1. 00 34. 12 D c

ATOM 15517 CG2 VAL D 146 38. 531 -40. 038 -20. ,892 1. 00 36. 56 D c

ATOM 15521 C VAL D 146 39. 679 -37. 520 -18. ,201 1. 00 36. 13 D c

ATOM 15522 O VAL D 146 40. 666 -36. 929 -18, ,642 1. 00 35. 35 D 0

ATOM 15524 N GLN D 147 39. 390 -37. 584 -16, .905 1. 00 40. 14 D N

ATOM 15525 CA GLN D 147 40. 224 -36. 961 -15, .872 1. 00 38. 74 D c

ATOM 15527 CB GLN D 147 39. 396 -35. 920 -15, .100 1. 00 43. 79 D c

ATOM 15530 CG GLN D 147 40. 103 -35. 254 -13, .909 1. 00 45. 49 D c

ATOM 15533 CD GLN D 147 41. 346 -34. 466 -14, .307 1. 00 50. 28 D c

ATOM 15534 OEl GLN D 147 42. 412 -34. 607 -13, .693 1. 00 50. 78 D 0

ATOM 15535 NE2 GLN D 147 41. 214 -33. 628 -15, .336 1. 00 52. 62 D N

ATOM 15538 C GLN D 147 40. 767 -38. 038 -14, .930 1. 00 36. 50 D c

ATOM 15539 O GLN D 147 39. 995 -38. 772 -14, .308 1. 00 34. 45 D 0

ATOM 15541 N TRP D 148 42. 092 -38. 130 -14, .827 1. 00 34. 03 D N

ATOM 15542 CA TRP D 148 42. 722 -39. 067 -13, .898 1. 00 34. 45 D c

ATOM 15544 CB TRP D 148 44. 066 -39. 544 -14, .446 1. 00 30. 66 D c

ATOM 15547 CG TRP D 148 43. 918 -40. 598 -15, .490 1. 00 29. 58 D c

ATOM 15548 CDl TRP D 148 44. 074 -40. 449 -16, .834 1. 00 29. 30 D c

ATOM 15550 NEl TRP D 148 43. 845 -41. 643 -17, .467 1. 00 29. 69 D N

ATOM 15552 CE2 TRP D 148 43. 531 -42. 591 -16.530 1. 00 29. 30 D c

ATOM 15553 CD2 TRP D 148 43. 562 -41. 967 -15, .274 1. 00 29. 25 D c

ATOM 15554 CE3 TRP D 148 43. 280 -42. 729 -14, .135 1. 00 28. 96 D c

ATOM 15556 CZ3 TRP D 148 42. 971 -44. 066 -14, .287 1. 00 28. 54 D c

ATOM 15558 CH2 TRP D 148 42. 954 -44. 660 -15, .547 1. 00 29. 27 D c

ATOM 15560 CZ2 TRP D 148 43. 232 -43. 942 -16, .681 1. 00 29. 79 D c

ATOM 15562 C TRP D 148 42. 915 -38. 451 -12, .510 1. 00 35. 26 D c

ATOM 15563 O TRP D 148 43. 365 -37. 316 -12, .386 1. 00 35. 44 D 0

ATOM 15565 N LYS D 149 42. ,548 -39. 208 -11, .479 1. 00 35. 54 D N

ATOM 15566 CA LYS D 149 42. 760 -38. 815 -10 .095 1. 00 38. 11 D C cyno fD_Fab

ATOM 15568 CB LYS D 149 41. 427 -38, ,644 -9. 368 1. 00 40. ,72 D C

ATOM 15571 CG LYS D 149 40. 555 -37. ,472 -9. 795 1. 00 41.09 D C

ATOM 15574 CD LYS D 149 39. ,265 -37. .475 -8. 952 1. 00 41. ,77 D C

ATOM 15577 CE LYS D 149 38. 562 -36, .118 -8. ,888 1. 00 42. ,78 D C

ATOM 15580 NZ LYS D 149 37. 509 -35. .986 -9. 914 1. 00 42. ,94 D N

ATOM 15584 C LYS D 149 43. ,547 -39. ,917 -9. 382 1. 00 38. ,03 D C

ATOM 15585 O LYS D 149 43. 187 -41. ,086 -9. 474 1. 00 36. ,30 D 0

ATOM 15587 N VAL D 150 44. 609 -39. ,538 -8. 674 1. 00 37. ,91 D N

ATOM 15588 CA VAL D 150 45. 321 -40. ,452 -7. 781 1. 00 36. ,63 D C

ATOM 15590 CB VAL D 150 46. 800 -40. ,590 -8. 184 1. 00 34. ,89 D C

ATOM 15592 CGI VAL D 150 47. 487 -41.659 -7. 351 1. 00 33. ,82 D C

ATOM 15596 CG2 VAL D 150 46. ,911 -40. .922 -9. 659 1. 00 31. ,87 D c

ATOM 15600 C VAL D 150 45. 195 -39. ,926 -6. 345 1. 00 37, ,19 D c

ATOM 15601 0 VAL D 150 45. 719 -38. ,856 -6. 020 1. 00 37. ,56 D 0

ATOM 15603 N ASP D 151 44. 493 -40. ,676 -5. 496 1. 00 35. 96 D N

ATOM 15604 CA ASP D 151 44. 184 -40. ,243 -4. 124 1. 00 37. 33 D c

ATOM 15606 CB ASP D 151 45. 455 -40. ,143 -3. 245 1. 00 37. 08 D c

ATOM 15609 CG ASP D 151 45. 949 -41. ,499 -2. 724 1. 00 34. ,84 D c

ATOM 15610 ODl ASP D 151 45. 172 -42. ,482 -2. 698 1. 00 32. 13 D 0

ATOM 15611 OD2 ASP D 151 47. 129 -41. ,560 -2. 311 1. 00 32. ,66 D 0

ATOM 15612 C ASP D 151 43. 440 -38. ,903 -4. 172 1. 00 37, ,55 D c

ATOM 15613 O ASP D 151 43. 746 -37. ,970 -3. 428 1. 00 37. ,91 D 0

ATOM 15615 N ASN D 152 42. 470 -38. ,828 -5. 077 1. 00 37. ,12 D N

ATOM 15616 CA ASN D 152 41. 647 -37. ,631 -5. 312 1. 00 38. .08 D c

ATOM 15618 CB ASN D 152 40. 775 -37. ,325 -4. 088 1. 00 40.69 D c

ATOM 15621 CG ASN D 152 39. 363 -36. ,897 -4. 477 1. 00 45. ,14 D c

ATOM 15622 ODl ASN D 152 38. 914 -35. ,800 -4. 129 1. 00 45. 59 D 0

ATOM 15623 ND2 ASN D 152 38. 665 -37. ,757 -5. 221 1. 00 47. ,05 D N

ATOM 15626 C ASN D 152 42. 373 -36. ,355 -5. 795 1. 00 36. ,43 D c

ATOM 15627 O ASN D 152 41.743 -35. ,305 -5. 926 1. 00 36. ,65 D 0

ATOM 15629 N ALA D 153 43. 673 -36. ,446 -6. 078 1. 00 33. ,09 D N

ATOM 15630 CA ALA D 153 44. 406 -35. ,337 -6. 679 1. 00 33. ,65 D c

ATOM 15632 CB ALA D 153 45. 860 -35. ,362 -6. 262 1. 00 31. ,73 D c

ATOM 15636 C ALA D 153 44. 289 -35. ,448 -8. 198 1. 00 33. ,55 D c

ATOM 15637 O ALA D 153 44. 605 -36. ,488 -8. 777 1. 00 30. ,56 D 0

ATOM 15639 N LEU D 154 43. 833 -34. ,369 -8. 830 1. 00 34. ,49 D N

ATOM 15640 CA LEU D 154 43. 655 -34. ,325 -10. 276 1. 00 35. ,99 D c

ATOM 15642 CB LEU D 154 42. 848 -33. ,077 -10. 664 1. 00 40. ,15 D c

ATOM 15645 CG LEU D 154 41.387 -33. ,066 -10. ,193 1. 00 43. ,14 D c

ATOM 15647 CDl LEU D 154 40. 756 -31.690 -10. ,337 1. 00 42. ,70 D c

ATOM 15651 CD2 LEU D 154 40. 578 -34. ,084 -10. ,975 1. 00 45. ,09 D c

ATOM 15655 C LEU D 154 45. 001 -34. ,357 -11. ,019 1. 00 35. ,56 D c

ATOM 15656 O LEU D 154 45. 910 -33. ,588 -10. 710 1. 00 35. ,73 D 0

ATOM 15658 N GLN D 155 45. 114 -35. ,251 -11. 999 1. 00 33. ,47 D N

ATOM 15659 CA GLN D 155 46. 352 -35. ,438 -12. 744 1. 00 33. ,18 D c

ATOM 15661 CB GLN D 155 46. 543 -36. ,920 -13. 088 1. 00 32. ,91 D c

ATOM 15664 CG GLN D 155 46. 513 -37, .874 -11. 909 1. 00 32, .02 D c

ATOM 15667 CD GLN D 155 47. ,631 -37, .627 -10. ,930 1. 00 29, .51 D c

ATOM 15668 OEl GLN D 155 47. 389 -37, .326 -9. ,760 1. 00 25, ,58 D 0

ATOM 15669 NE2 GLN D 155 48. ,865 -37. ,743 -11. ,400 1. 00 26. .71 D N

ATOM 15672 C GLN D 155 46. 346 -34. ,651 -14. ,046 1. 00 33. ,11 D c

ATOM 15673 O GLN D 155 45. 292 -34. ,403 -14. ,634 1. 00 33. ,54 D 0

ATOM 15675 N SER D 156 47. 536 -34, ,260 -14. ,490 1. 00 33. ,03 D N

ATOM 15676 CA SER D 156 47. 744 -33. ,837 -15. ,870 1. 00 37. ,14 D c

ATOM 15678 CB SER D 156 47. 312 -32. ,387 -16. ,107 1. 00 42. ,00 D c

ATOM 15681 OG SER D 156 48. ,295 -31.473 -15. ,641 1. 00 44, .81 D 0

ATOM 15683 C SER D 156 49. ,212 -33, .999 -16. ,221 1. 00 37, .76 D c

ATOM 15684 O SER D 156 50. ,075 -34, ,027 -15. ,335 1. 00 29, .55 D 0

ATOM 15686 N GLY D 157 49. ,478 -34, .112 -17. ,522 1. 00 37, .09 D N

ATOM 15687 CA GLY D 157 50. ,830 -34, .292 -18. 036 1. 00 37, .74 D c

ATOM 15690 C GLY D 157 51. ,270 -35, .741 -18. ,145 1. 00 39, .38 D c

ATOM 15691 O GLY D 157 52. ,274 -36. .025 -18. 792 1. 00 43, .20 D 0

ATOM 15693 N ASN D 158 50. 521 -36. ,659 -17. ,532 1. 00 38, .65 D N

ATOM 15694 CA ASN D 158 50. 937 -38. ,063 -17. ,442 1. 00 36, .08 D c

ATOM 15696 CB ASN D 158 51. ,246 -38, .442 -15. ,977 1. 00 35, .48 D c

ATOM 15699 CG ASN D 158 50. ,128 -38, .074 -15. ,010 1. 00 33, .80 D c

ATOM 15700 ODl ASN D 158 48. ,986 -37, .842 -15. ,399 1. 00 35, .68 D 0

ATOM 15701 ND2 ASN D 158 50. ,467 -38, .020 -13. ,734 1. 00 33, .93 D N cyno fD_Fab

ATOM 15704 C ASN D 158 49. ,954 -39. ,056 -18. 072 1.00 34. ,29 D C

ATOM 15705 O ASN D 158 50. 002 -40. ,245 -17. 777 1.00 33. ,25 D 0

ATOM 15707 N SER D 159 49. ,080 -38. ,565 -18. 949 1.00 34. ,43 D N

ATOM 15708 CA SER D 159 48. ,137 -39. 424 -19. 664 1.00 32. ,18 D C

ATOM 15710 CB SER D 159 46. ,729 -39. 364 -19. 043 1.00 30. ,03 D C

ATOM 15713 OG SER D 159 46. ,224 -38. ,042 -18. 969 1.00 28. ,71 D 0

ATOM 15715 C SER D 159 48. ,088 -39. ,079 -21. 147 1.00 32. ,21 D c

ATOM 15716 O SER D 159 48. ,432 -37. ,963 -21. 544 1.00 30. 66 D 0

ATOM 15718 N GLN D 160 47. ,691 -40. ,065 -21. 954 1.00 32. ,47 D N

ATOM 15719 CA GLN D 160 47. ,448 -39. ,883 -23. 386 1.00 30. ,75 D c

ATOM 15721 CB GLN D 160 48. ,608 -40. ,438 -24. 202 1.00 30. ,58 D c

ATOM 15724 CG GLN D 160 49. ,943 -39. 843 -23. 843 1.00 31. ,86 D c

ATOM 15727 CD GLN D 160 51.003 -40. 138 -24. 881 1.00 31.77 D c

ATOM 15728 OEl GLN D 160 51. 282 -39. 310 -25. 754 1.00 32. 06 D 0

ATOM 15729 NE2 GLN D 160 51. 597 -41. 321 -24. 797 1.00 30. ,39 D N

ATOM 15732 C GLN D 160 46. ,175 -40. ,599 -23. 803 1.00 31. ,17 D c

ATOM 15733 O GLN D 160 45. ,767 -41. 566 -23. 163 1.00 33. ,67 D 0

ATOM 15735 N GLU D 161 45. 569 -40. ,123 -24. 889 1.00 31.98 D N

ATOM 15736 CA GLU D 161 44. 319 -40. 673 -25. 406 1.00 31. ,46 D c

ATOM 15738 CB GLU D 161 43. 222 -39. 619 -25. 396 1.00 33. ,09 D c

ATOM 15741 CG GLU D 161 42. 811 -39. 200 -24. 023 1.00 35. ,15 D c

ATOM 15744 CD GLU D 161 41. 595 -38. 298 -24. 026 1.00 36. ,71 D c

ATOM 15745 OEl GLU D 161 41. 254 -37. 730 -25. 097 1.00 38. ,31 D 0

ATOM 15746 OE2 GLU D 161 40. 985 -38. 155 -22. 945 1.00 41. ,05 D 0

ATOM 15747 C GLU D 161 44. ,450 -41. ,179 -26. 827 1.00 27. ,44 D c

ATOM 15748 O GLU D 161 45. 317 -40. ,748 -27. 588 1.00 25. ,73 D 0

ATOM 15750 N SER D 162 43. 562 -42. ,102 -27. 164 1.00 27. 69 D N

ATOM 15751 CA SER D 162 43. 418 -42. ,603 -28. 512 1.00 28. 23 D c

ATOM 15753 CB SER D 162 44. 196 -43. ,893 -28. 658 1.00 30. ,31 D c

ATOM 15756 OG SER D 162 44. 415 -44. 198 -30. 010 1.00 30. ,35 D 0

ATOM 15758 C SER D 162 41. 945 -42. 869 -28. 707 1.00 28. ,46 D c

ATOM 15759 O SER D 162 41. 287 -43. 382 -27. 804 1.00 27. ,71 D 0

ATOM 15761 N VAL D 163 41. 406 -42. 489 -29. 858 1.00 30. ,04 D N

ATOM 15762 CA VAL D 163 39. 987 -42. ,682 -30. 116 1.00 27. ,10 D c

ATOM 15764 CB VAL D 163 39. 246 -41. ,346 -30. 259 1.00 27. ,85 D c

ATOM 15766 CGI VAL D 163 37. ,750 -41. ,591 -30. 378 1.00 28. ,84 D c

ATOM 15770 CG2 VAL D 163 39. ,537 -40. ,438 -29. 062 1.00 28. ,04 D c

ATOM 15774 C VAL D 163 39. 850 -43. ,491 -31. 385 1.00 27. ,06 D c

ATOM 15775 O VAL D 163 40. 619 -43. ,279 -32. 324 1.00 25. ,24 D 0

ATOM 15777 N THR D 164 38. 903 -44. ,432 -31. 405 1.00 27. ,15 D N

ATOM 15778 CA THR D 164 38. 660 -45. ,235 -32. 603 1.00 28. ,10 D c

ATOM 15780 CB THR D 164 37. 803 -46. 520 -32. 350 1.00 29. ,51 D c

ATOM 15782 OGl THR D 164 36. ,661 -46. ,219 -31. 535 1.00 34. ,64 D 0

ATOM 15784 CG2 THR D 164 38. ,629 -47. ,628 -31. ,685 1.00 27. ,01 D c

ATOM 15788 C THR D 164 37. ,946 -44. ,371 -33. ,615 1.00 32. ,43 D c

ATOM 15789 O THR D 164 37. ,360 -43. ,342 -33. ,268 1.00 36. ,29 D 0

ATOM 15791 N GLU D 165 37. ,987 -44. ,781 -34. 877 1.00 30. ,38 D N

ATOM 15792 CA GLU D 165 37. ,078 -44. ,202 -35. 834 1.00 31. ,13 D C

ATOM 15794 CB GLU D 165 37. 494 -44. ,494 -37. 274 1.00 36. ,06 D c

ATOM 15797 CG GLU D 165 38. ,190 -43. ,307 -37. 948 1.00 44. ,65 D c

ATOM 15800 CD GLU D 165 37. 282 -42. ,063 -38. 102 1.00 52. ,43 D c

ATOM 15801 OEl GLU D 165 36. ,029 -42. ,203 -38. ,273 1.00 49. ,18 D 0

ATOM 15802 OE2 GLU D 165 37. ,845 -40. ,938 -38. ,046 1.00 52. .85 D 0

ATOM 15803 C GLU D 165 35. ,677 -44. ,718 -35. ,541 1.00 28. ,03 D c

ATOM 15804 O GLU D 165 35. ,496 -45. ,702 -34. 837 1.00 25. ,73 D 0

ATOM 15806 N GLN D 166 34. 692 -44. ,036 -36. 099 1.00 30. ,47 D N

ATOM 15807 CA GLN D 166 33. 297 -44. ,414 -35. 934 1.00 30. ,73 D c

ATOM 15809 CB GLN D 166 32. ,415 -43. ,488 -36. ,776 1.00 29. ,32 D c

ATOM 15812 CG GLN D 166 30. ,991 -43. 421 -36. ,326 1.00 30. ,43 D c

ATOM 15815 CD GLN D 166 30. 241 -42. ,266 -36. ,920 1.00 30. 89 D c

ATOM 15816 OEl GLN D 166 30. 576 -41. ,766 -38. 014 1.00 34. ,28 D 0

ATOM 15817 NE2 GLN D 166 29. 202 -41. ,839 -36. 222 1.00 26. ,71 D N

ATOM 15820 C GLN D 166 33. ,068 -45. ,883 -36. ,321 1.00 28. ,74 D C

ATOM 15821 O GLN D 166 33. ,509 -46. ,338 -37. ,374 1.00 25. ,41 D 0

ATOM 15823 N ASP D 167 32. ,374 -46. ,614 -35. ,455 1.00 30. ,23 D N

ATOM 15824 CA ASP D 167 32. 185 -48. ,045 -35. 637 1.00 28. ,99 D C

ATOM 15826 CB ASP D 167 31. ,597 -48. ,686 -34. ,379 1.00 32. ,03 D C

ATOM 15829 CG ASP D 167 31. ,454 -50. ,187 -34. ,510 1.00 32. ,07 D C cyno fD_Fab

ATOM 15830 ODl ASP D 167 32.474 -50. 908 -34. ,441 1.00 37. ,59 D 0

ATOM 15831 OD2 ASP D 167 30. 313 -50. 644 -34. ,696 1.00 32. 20 D 0

ATOM 15832 C ASP D 167 31. 268 -48. 303 -36. ,803 1.00 28. ,01 D C

ATOM 15833 O ASP D 167 30. 302 -47. 574 -36. ,983 1.00 30. ,14 D 0

ATOM 15835 N SER D 168 31. 568 -49. 354 -37. ,575 1.00 28. ,72 D N

ATOM 15836 CA SER D 168 30. 867 -49. 650 -38. ,828 1.00 29. ,80 D C

ATOM 15838 CB SER D 168 31. 730 -50. 541 -39. ,733 1.00 31.87 D C

ATOM 15841 OG SER D 168 31.876 -51. 855 -39. ,185 1.00 29. ,49 D 0

ATOM 15843 C SER D 168 29. 503 -50. 309 -38. ,628 1.00 29. ,96 D C

ATOM 15844 O SER D 168 28. 778 -50. 516 -39. ,599 1.00 30. ,34 D 0

ATOM 15846 N LYS D 169 29. 158 -50. 648 -37. ,384 1.00 33. ,12 D N

ATOM 15847 CA LYS D 169 27. 887 -51.301 -37. ,093 1.00 34. ,76 D C

ATOM 15849 CB LYS D 169 28. 115 -52. 623 -36. ,356 1.00 39. ,32 D C

ATOM 15852 CG LYS D 169 28. 835 -53. 652 -37. ,223 1.00 41. ,84 D c

ATOM 15855 CD LYS D 169 28. 988 -55. 021 -36.555 1.00 43. ,16 D c

ATOM 15858 CE LYS D 169 29. 279 -56. 106 -37. ,592 1.00 45. ,57 D c

ATOM 15861 NZ LYS D 169 30. 065 -55. 586 -38. ,763 1.00 46. ,95 D N

ATOM 15865 C LYS D 169 26. 937 -50. 408 -36. ,318 1.00 33. ,26 D c

ATOM 15866 0 LYS D 169 25. 777 -50. 289 -36. ,703 1.00 32. ,76 D 0

ATOM 15868 N ASP D 170 27. 419 -49. 777 -35. ,247 1.00 33. ,20 D N

ATOM 15869 CA ASP D 170 26. 569 -48. 912 -34. ,424 1.00 36. ,00 D c

ATOM 15871 CB ASP D 170 26. 465 -49. 449 -32. ,979 1.00 40. ,28 D c

ATOM 15874 CG ASP D 170 27. 785 -49. 410 -32. ,221 1.00 42. .24 D c

ATOM 15875 ODl ASP D 170 28. 727 -48. 737 -32. ,678 1.00 42. 34 D 0

ATOM 15876 OD2 ASP D 170 27. 871 -50. 058 -31.152 1.00 45. ,54 D 0

ATOM 15877 C ASP D 170 26. 948 -47. 423 -34. ,443 1.00 33. 34 D c

ATOM 15878 O ASP D 170 26. 369 -46. 630 -33. 703 1.00 33. ,74 D 0

ATOM 15880 N SER D 171 27. 899 -47. 046 -35. ,292 1.00 33. ,62 D N

ATOM 15881 CA SER D 171 28. 255 -45. 632 -35. ,487 1.00 33. ,82 D c

ATOM 15883 CB SER D 171 27. 078 -44. 863 -36. ,103 1.00 25. ,73 D c

ATOM 15886 OG SER D 171 26. 557 -45. 586 -37. ,194 1.00 27. ,43 D 0

ATOM 15888 C SER D 171 28. 732 -44. 928 -34. ,207 1.00 32. ,41 D c

ATOM 15889 O SER D 171 28. 561 -43. 715 -34. ,070 1.00 31. ,95 D 0

ATOM 15891 N THR D 172 29. 348 -45. 685 -33. ,296 1.00 32. .89 D N

ATOM 15892 CA THR D 172 29. 850 -45. 124 -32. ,034 1.00 29. ,07 D c

ATOM 15894 CB THR D 172 29. 399 -45. 950 -30. ,806 1.00 29. 96 D c

ATOM 15896 OG1 THR D 172 29. 889 -47. 290 -30. ,917 1.00 30. ,75 D 0

ATOM 15898 CG2 THR D 172 27. 865 -45. 962 -30. ,675 1.00 25. ,69 D c

ATOM 15902 C THR D 172 31. 375 -44. 995 -32. ,029 1.00 24. ,97 D c

ATOM 15903 O THR D 172 32. 068 -45. 469 -32. ,927 1.00 26. ,50 D 0

ATOM 15905 N TYR D 173 31. 879 -44. 324 -31. ,004 1.00 28. ,98 D N

ATOM 15906 CA TYR D 173 33. 300 -44. ,157 -30. ,797 1.00 25. ,87 D c

ATOM 15908 CB TYR D 173 33. 625 -42. 669 -30. ,676 1.00 28. ,62 D c

ATOM 15911 CG TYR D 173 33. 320 -41. 861 -31. ,913 1.00 27. ,20 D c

ATOM 15912 CDl TYR D 173 34. 216 -41. 820 -32. ,968 1.00 27. ,80 D c

ATOM 15914 CEl TYR D 173 33. 959 -41. 072 -34. ,101 1.00 26. ,92 D c

ATOM 15916 cz TYR D 173 32. 770 -40. ,360 -34. .207 1.00 29, .72 D c

ATOM 15917 OH TYR D 173 32. 514 -39. ,636 -35. ,353 1.00 28. .75 D 0

ATOM 15919 CE2 TYR D 173 31. 856 -40. ,380 -33. .174 1.00 29. .12 D c

ATOM 15921 CD2 TYR D 173 32. 137 -41. ,131 -32. ,027 1.00 29. .23 D c

ATOM 15923 C TYR D 173 33. 731 -44. ,881 -29. ,531 1.00 27. ,51 D c

ATOM 15924 0 TYR D 173 32. 929 -45. ,109 -28. ,621 1.00 29. ,23 D 0

ATOM 15926 N SER D 174 35. 005 -45. ,246 -29. ,467 1.00 26. ,48 D N

ATOM 15927 CA SER D 174 35. 584 -45. ,769 -28. ,237 1.00 24. ,31 D c

ATOM 15929 CB SER D 174 35. 764 -47. ,287 -28, .317 1.00 24, .07 D c

ATOM 15932 OG SER D 174 34. 504 -47. ,933 -28, ,300 1.00 28, .45 D 0

ATOM 15934 C SER D 174 36. 906 -45. ,068 -27. ,952 1.00 19, .92 D c

ATOM 15935 0 SER D 174 37. 594 -44. ,642 -28, ,865 1.00 18, ,96 D 0

ATOM 15937 N LEU D 175 37. 252 -44. ,949 -26. .675 1.00 24, ,70 D N

ATOM 15938 CA LEU D 175 38. 438 -44. ,211 -26. .285 1.00 25, ,47 D c

ATOM 15940 CB LEU D 175 38. 041 -42. ,815 -25. ,816 1.00 25, .20 D c

ATOM 15943 CG LEU D 175 39. 119 -41. ,825 -25. ,364 1.00 22, .37 D c

ATOM 15945 CDl LEU D 175 38. 727 -40. ,446 -25, .867 1.00 25.49 D c

ATOM 15949 CD2 LEU D 175 39. 301 -41. ,833 -23, .846 1.00 23, .33 D c

ATOM 15953 C LEU D 175 39. 204 -44. ,929 -25, .195 1.00 26, .86 D c

ATOM 15954 0 LEU D 175 38. 613 -45. ,432 -24, .237 1.00 25, .28 D 0

ATOM 15956 N SER D 176 40. 525 -44. ,974 -25, .362 1.00 27, .38 D N

ATOM 15957 CA SER D 176 41. 428 -45. 410 -24, .316 1.00 29, .19 D c cyno fD_Fab

ATOM 15959 CB SER D 176 42. .442 -46. ,410 -24. 859 1. 00 33. ,77 D C

ATOM 15962 OG SER D 176 43. ,403 -45. ,767 -25. 680 1. 00 37. ,34 D 0

ATOM 15964 C SER D 176 42. .167 -44. ,203 -23. 754 1. 00 30. 52 D C

ATOM 15965 O SER D 176 42. ,667 -43. ,377 -24. 514 1. 00 30. ,01 D 0

ATOM 15967 N SER D 177 42. .219 -44. 111 -22. 424 1. 00 31. ,83 D N

ATOM 15968 CA SER D 177 43. ,109 -43. ,184 -21. 725 1. 00 30. ,27 D C

ATOM 15970 CB SER D 177 42. .320 -42. ,275 -20. 778 1. 00 30. ,61 D c

ATOM 15973 OG SER D 177 43, .035 -41. ,079 -20. 519 1. 00 32. ,91 D 0

ATOM 15975 C SER D 177 44. .118 -44. ,009 -20. 930 1. 00 30. ,59 D c

ATOM 15976 O SER D 177 43, ,726 -44. ,911 -20. 206 1. 00 29. ,89 D 0

ATOM 15978 N THR D 178 45. .405 -43. ,693 -21.070 1. 00 28. ,97 D N

ATOM 15979 CA THR D 178 46. .458 -44. ,406 -20. 377 1. 00 28. 38 D c

ATOM 15981 CB THR D 178 47. ,406 -45. ,101 -21. 387 1. 00 29. 09 D c

ATOM 15983 OGl THR D 178 46. ,634 -45. ,953 -22. 242 1. 00 31. ,29 D 0

ATOM 15985 CG2 THR D 178 48. ,480 -45. ,940 -20. 669 1. 00 28. ,86 D c

ATOM 15989 C THR D 178 47. ,245 -43. ,469 -19. 451 1. 00 28. ,06 D c

ATOM 15990 O THR D 178 47, ,981 -42. ,607 -19. 923 1. 00 27. ,36 D 0

ATOM 15992 N LEU D 179 47, .072 -43. ,649 -18. 136 1. 00 26. ,29 D N

ATOM 15993 CA LEU D 179 47. ,867 -42. ,945 -17. 113 1. 00 26. ,08 D c

ATOM 15995 CB LEU D 179 47. .086 -42. ,861 -15. 791 1. 00 25. ,21 D c

ATOM 15998 CG LEU D 179 47. ,722 -42. ,138 -14. 599 1. 00 26. ,26 D c

ATOM 16000 CDl LEU D 179 47. ,712 -40. 632 -14. 814 1. 00 28. ,61 D c

ATOM 16004 CD2 LEU D 179 47. ,002 -42. ,500 -13. 311 1. 00 25. ,59 D c

ATOM 16008 C LEU D 179 49. ,169 -43. ,702 -16. 897 1. 00 27. 09 D c

ATOM 16009 O LEU D 179 49. ,139 -44. ,900 -16. 613 1. 00 27. ,94 D 0

ATOM 16011 N THR D 180 50. ,309 -43. ,021 -17. 045 1. 00 30. ,50 D N

ATOM 16012 CA THR D 180 51. ,626 -43. ,654 -16. 854 1. 00 30. 60 D c

ATOM 16014 CB THR D 180 52. .514 -43. ,543 -18. 121 1. 00 32. ,67 D c

ATOM 16016 OGl THR D 180 51. .854 -44. ,176 -19. 228 1. 00 33. 88 D 0

ATOM 16018 CG2 THR D 180 53. ,866 -44. ,228 -17. 902 1. 00 30. ,78 D c

ATOM 16022 C THR D 180 52. ,371 -43. ,102 -15. 622 1. 00 31. ,85 D c

ATOM 16023 O THR D 180 52. ,488 -41. ,880 -15. 427 1. 00 29. ,00 D 0

ATOM 16025 N LEU D 181 52. ,858 -44. ,027 -14. 794 1. 00 32. ,12 D N

ATOM 16026 CA LEU D 181 53. ,596 -43. ,712 -13. 569 1. 00 33. ,43 D c

ATOM 16028 CB LEU D 181 52. ,731 -44. ,015 -12. 339 1. 00 31. 62 D c

ATOM 16031 CG LEU D 181 51. ,864 -42. ,899 -11. 756 1. 00 29. ,87 D c

ATOM 16033 CDl LEU D 181 50. ,536 -42. ,775 -12. 449 1. 00 25. ,58 D c

ATOM 16037 CD2 LEU D 181 51. ,648 -43. ,164 -10. 271 1. 00 32. ,46 D c

ATOM 16041 C LEU D 181 54. ,880 -44. ,534 -13. 476 1. 00 34. ,17 D c

ATOM 16042 0 LEU D 181 55. ,022 -45. ,561 -14. 135 1. 00 33. ,85 D 0

ATOM 16044 N SER D 182 55. ,818 -44. ,084 -12. 648 1. 00 38. ,37 D N

ATOM 16045 CA SER D 182 56. ,928 -44. ,941 -12. 240 1. 00 39. ,27 D c

ATOM 16047 CB SER D 182 58. ,045 -44. ,123 -11. 593 1. 00 40. ,02 D c

ATOM 16050 OG SER D 182 57. ,671 -43. ,690 -10. 296 1. 00 42. ,36 D 0

ATOM 16052 C SER D 182 56. ,377 -45. ,953 -11. 243 1. 00 39. ,75 D c

ATOM 16053 0 SER D 182 55. ,328 -45. ,726 -10. 639 1. 00 37. ,90 D 0

ATOM 16055 N LYS D 183 57. ,078 -47. ,070 -11.074 1. 00 43. ,74 D N

ATOM 16056 CA LYS D 183 56. ,732 -48. ,040 -10. 035 1. 00 44. ,36 D c

ATOM 16058 CB LYS D 183 57. ,684 -49. ,240 -10. 069 1. 00 44. ,77 D c

ATOM 16061 CG LYS D 183 57. ,254 -50. ,413 -9. 191 1. 00 44. ,98 D c

ATOM 16064 CD LYS D 183 58. ,378 -51.442 -9. 035 1. 00 45. .67 D c

ATOM 16067 CE LYS D 183 57. .968 -52. ,587 -8. 120 1. 00 45. .92 D c

ATOM 16070 NZ LYS D 183 57. .676 -52. ,116 -6. 729 1. 00 45. ,82 D N

ATOM 16074 C LYS D 183 56. .796 -47. ,355 -8. 669 1. 00 46. .88 D c

ATOM 16075 0 LYS D 183 55. ,909 -47. ,539 -7. 829 1. 00 47, ,63 D 0

ATOM 16077 N ALA D 184 57, ,848 -46. ,564 -8. 462 1. 00 46.70 D N

ATOM 16078 CA ALA D 184 58. ,023 -45. ,801 -7. 226 1. 00 45. ,20 D c

ATOM 16080 CB ALA D 184 59, ,250 -44. ,890 -7. 332 1. 00 46.92 D c

ATOM 16084 C ALA D 184 56. ,786 -44. ,973 -6. 884 1. 00 44. ,41 D c

ATOM 16085 0 ALA D 184 56. ,285 -45. ,034 -5. 762 1. 00 41. ,87 D 0

ATOM 16087 N ASP D 185 56, ,289 -44. ,212 -7. 855 1. 00 43, ,99 D N

ATOM 16088 CA ASP D 185 55, .181 -43. ,293 -7. ,606 1. 00 42, .27 D c

ATOM 16090 CB ASP D 185 55, .165 -42. ,173 -8. 653 1. 00 44, .69 D c

ATOM 16093 CG ASP D 185 54. ,563 -40. ,883 -8. 116 1. 00 49, .02 D c

ATOM 16094 ODl ASP D 185 53. .582 -40. ,385 -8. 714 1. 00 50, .64 D 0

ATOM 16095 OD2 ASP D 185 55. .065 -40. ,369 -7. 086 1. 00 50, .57 D 0

ATOM 16096 C ASP D 185 53. ,824 -44. Oil -7. 547 1. 00 40, .11 D c

ATOM 16097 0 ASP D 185 52. ,938 -43. ,587 -6. 807 1. 00 38, .69 D 0 cyno fD_Fab

ATOM 16099 N TYR D 186 53. ,670 -45. ,094 -8. 313 1.00 37.25 D N

ATOM 16100 CA TYR D 186 52. ,436 -45. ,893 -8. 300 1.00 36.60 D C

ATOM 16102 CB TYR D 186 52. ,461 -46. ,973 -9. 397 1.00 34.06 D c

ATOM 16105 CG TYR D 186 51. 267 -47. ,919 -9. 363 1.00 33.86 D c

ATOM 16106 CDl TYR D 186 49. 988 -47. ,473 -9. 678 1.00 33.27 D c

ATOM 16108 CEl TYR D 186 48. ,887 -48. ,333 -9. 645 1.00 32.91 D c

ATOM 16110 CZ TYR D 186 49. ,067 -49. ,656 -9. 289 1.00 34.12 D c

ATOM 16111 OH TYR D 186 47. 989 -50. ,506 -9. 240 1.00 34.03 D 0

ATOM 16113 CE2 TYR D 186 50. 329 -50. ,128 -8. 976 1.00 32.80 D c

ATOM 16115 CD2 TYR D 186 51. ,421 -49. ,261 -9. 017 1.00 33.55 D c

ATOM 16117 C TYR D 186 52. 168 -46. ,536 -6. 930 1.00 35.62 D c

ATOM 16118 O TYR D 186 51.053 -46. 460 -6. 417 1.00 32.60 D 0

ATOM 16120 N GLU D 187 53. 197 -47. 145 -6. 339 1.00 37.51 D N

ATOM 16121 CA GLU D 187 53. 074 -47. 832 -5. 033 1.00 40.24 D c

ATOM 16123 CB GLU D 187 54. 318 -48. ,695 -4. 753 1.00 44.53 D c

ATOM 16126 CG GLU D 187 54. 672 -49. ,730 -5. 834 1.00 48.07 D c

ATOM 16129 CD GLU D 187 53. 838 -50. ,999 -5. 764 1.00 50.87 D c

ATOM 16130 OEl GLU D 187 52. 691 -50. ,949 -5. 262 1.00 51.16 D 0

ATOM 16131 OE2 GLU D 187 54. 332 -52. ,051 -6. 229 1.00 52.56 D 0

ATOM 16132 C GLU D 187 52. 868 -46. ,861 -3. 852 1.00 39.07 D c

ATOM 16133 O GLU D 187 52. 556 -47. ,277 -2. 738 1.00 37.05 D 0

ATOM 16135 N LYS D 188 53. 055 -45. ,574 -4. 120 1.00 40.18 D N

ATOM 16136 CA LYS D 188 52. 930 -44. ,494 -3. 142 1.00 39.27 D c

ATOM 16138 CB LYS D 188 53. 542 -43. ,233 -3. 775 1.00 41.65 D c

ATOM 16141 CG LYS D 188 54. 252 -42. ,270 -2. 865 1.00 43.39 D c

ATOM 16144 CD LYS D 188 54. 604 -40. ,995 -3. 642 1.00 43.40 D c

ATOM 16147 CE LYS D 188 55. 868 -40. .335 -3. 109 1.00 44.77 D c

ATOM 16150 NZ LYS D 188 57. 085 -41. ,089 -3. 532 1.00 46.07 D N

ATOM 16154 C LYS D 188 51. 463 -44. ,213 -2. 746 1.00 38.41 D c

ATOM 16155 0 LYS D 188 51.188 -43. ,743 -1. 630 1.00 34.22 D 0

ATOM 16157 N HIS D 189 50. 531 -44. ,494 -3. 667 1.00 37.82 D N

ATOM 16158 CA HIS D 189 49. 127 -44. ,058 -3. 547 1.00 36.28 D c

ATOM 16160 CB HIS D 189 48. 822 -43. ,007 -4. 629 1.00 35.79 D c

ATOM 16163 CG HIS D 189 49. ,745 -41.821 -4. 602 1.00 36.10 D c

ATOM 16164 NDl HIS D 189 49. 762 -40. ,909 -3. 564 1.00 36.34 D N

ATOM 16166 CEl HIS D 189 50. 674 -39. ,982 -3. ,809 1.00 36.94 D c

ATOM 16168 NE2 HIS D 189 51. 243 -40. ,255 -4. 972 1.00 35.63 D N

ATOM 16170 CD2 HIS D 189 50. 679 -41.397 -5. 489 1.00 33.77 D C

ATOM 16172 C HIS D 189 48. 132 -45. ,234 -3. 621 1.00 34.10 D c

ATOM 16173 0 HIS D 189 48. 481 -46, ,325 -4. 069 1.00 31.99 D 0

ATOM 16175 N LYS D 190 46. 894 -45. ,004 -3. 181 1.00 34.90 D N

ATOM 16176 CA LYS D 190 45. 894 -46. ,077 -3. 047 1.00 36.79 D c

ATOM 16178 CB LYS D 190 45. 215 -45. ,991 -1. ,671 1.00 38.91 D c

ATOM 16181 CG LYS D 190 44. 106 -47, ,030 -1. ,425 1.00 38.77 D c

ATOM 16184 CD LYS D 190 43. 619 -46. ,998 0. ,031 1.00 40.74 D c

ATOM 16187 CE LYS D 190 42. 582 -48, ,087 0. 333 1.00 41.42 D c

ATOM 16190 NZ LYS D 190 42. 602 -48. ,512 1. ,771 1.00 39.05 D N

ATOM 16194 C LYS D 190 44. 823 -46. ,056 -4. ,137 1.00 38.54 D c

ATOM 16195 0 LYS D 190 44. 696 -47, ,007 -4. ,913 1.00 39.33 D 0

ATOM 16197 N VAL D 191 44. 053 -44. ,968 -4. ,170 1.00 37.39 D N

ATOM 16198 CA VAL D 191 42. 872 -44. ,854 -5. ,023 1.00 34.04 D c

ATOM 16200 CB VAL D 191 41. 814 -43, ,901 -4. ,407 1.00 33.29 D c

ATOM 16202 CGI VAL D 191 40. 522 -43, .924 -5. ,228 1.00 30.42 D c

ATOM 16206 CG2 VAL D 191 41. ,551 -44, .249 -2. ,922 1.00 30.00 D c

ATOM 16210 C VAL D 191 43. ,258 -44, ,315 -6. ,395 1.00 34.11 D c

ATOM 16211 0 VAL D 191 43. ,824 -43. .223 -6. ,502 1.00 33.76 D 0

ATOM 16213 N TYR D 192 42. 951 -45. ,096 -7. ,431 1.00 32.52 D N

ATOM 16214 CA TYR D 192 43. ,135 -44. ,689 -8. ,820 1.00 30.69 D c

ATOM 16216 CB TYR D 192 44. ,060 -45. ,676 -9. ,536 1.00 28.33 D c

ATOM 16219 CG TYR D 192 45. ,498 -45. .483 -9. ,122 1.00 27.51 D c

ATOM 16220 CDl TYR D 192 46. ,376 -44. ,740 -9. ,904 1.00 27.16 D c

ATOM 16222 CEl TYR D 192 47. ,686 -44, .544 -9. ,517 1.00 27.83 D c

ATOM 16224 CZ TYR D 192 48. ,130 -45, .078 -8. ,318 1.00 26.98 D c

ATOM 16225 OH TYR D 192 49. ,424 -44, .885 -7. ,919 1.00 26.79 D 0

ATOM 16227 CE2 TYR D 192 47. ,279 -45, ,805 -7. ,522 1.00 28.45 D c

ATOM 16229 CD2 TYR D 192 45. ,964 -45, .998 -7. ,927 1.00 29.20 D c

ATOM 16231 C TYR D 192 41. ,776 -44. ,615 -9. ,490 1.00 27.53 D c

ATOM 16232 0 TYR D 192 41. ,050 -45. .599 -9. ,518 1.00 24.27 D 0 cyno fD_Fab

ATOM 16234 N ALA D 193 41, .432 -43. ,438 -10. 013 1. 00 30. ,95 D N

ATOM 16235 CA ALA D 193 40. ,110 -43. 192 -10. 587 1. 00 32. ,32 D C

ATOM 16237 CB ALA D 193 39. ,261 -42. ,390 -9. ,598 1. 00 29. ,12 D C

ATOM 16241 C ALA D 193 40. ,204 -42. 450 -11. ,915 1. 00 31. ,75 D C

ATOM 16242 O ALA D 193 40, .863 -41. ,418 -12. ,001 1. 00 29. ,95 D 0

ATOM 16244 N CYS D 194 39, .559 -42. 972 -12. ,955 1. 00 38. ,65 D N

ATOM 16245 CA CYS D 194 39. ,306 -42. ,167 -14. ,150 1. 00 38. ,12 D c

ATOM 16247 CB CYS D 194 39. ,603 -42. 925 -15. ,456 1. 00 41.97 D c

ATOM 16250 SG CYS D 194 38. ,380 -44. 133 -15. ,993 1. 00 45. ,44 D s

ATOM 16252 C CYS D 194 37. ,864 -41. ,667 -14. ,069 1. 00 38. ,55 D c

ATOM 16253 O CYS D 194 36. ,938 -42. ,445 -13. 825 1. 00 35. 85 D 0

ATOM 16255 N GLU D 195 37. ,699 -40. 354 -14. ,225 1. 00 41. 02 D N

ATOM 16256 CA GLU D 195 36. ,393 -39. 700 -14. 172 1. 00 40. 19 D c

ATOM 16258 CB GLU D 195 36. ,441 -38. ,461 -13. ,267 1. 00 41. ,74 D c

ATOM 16261 CG GLU D 195 35. ,075 -37. ,797 -13. ,038 1. 00 43. ,78 D c

ATOM 16264 CD GLU D 195 35. ,168 -36. 370 -12. ,504 1. 00 44. 86 D c

ATOM 16265 OEl GLU D 195 35. ,699 -35. 487 -13. ,220 1. 00 45. ,69 D 0

ATOM 16266 OE2 GLU D 195 34. ,677 -36. 130 -11.379 1. 00 45. .42 D 0

ATOM 16267 C GLU D 195 36. ,008 -39. 296 -15. ,589 1. 00 36. 20 D c

ATOM 16268 O GLU D 195 36. ,749 -38. 578 -16. ,256 1. 00 33. 18 D 0

ATOM 16270 N VAL D 196 34. ,840 -39. 746 -16. ,036 1. 00 36. 84 D N

ATOM 16271 CA VAL D 196 34. ,418 -39. ,564 -17. ,421 1. 00 37. ,63 D c

ATOM 16273 CB VAL D 196 34. ,080 -40. 921 -18. ,076 1. 00 36. ,55 D c

ATOM 16275 CGl VAL D 196 33. ,663 -40. 725 -19. ,529 1. 00 36. ,34 D c

ATOM 16279 CG2 VAL D 196 35. ,279 -41. ,875 -17. ,980 1. 00 35. ,41 D c

ATOM 16283 C VAL D 196 33. ,220 -38. 612 -17. ,530 1. 00 36. 83 D c

ATOM 16284 O VAL D 196 32. ,188 -38. 821 -16. ,883 1. 00 33. 70 D 0

ATOM 16286 N THR D 197 33. ,378 -37. 565 -18. ,344 1. 00 38. 36 D N

ATOM 16287 CA THR D 197 32. ,293 -36. 626 -18. ,666 1. 00 37. 73 D c

ATOM 16289 CB THR D 197 32. ,710 -35. ,166 -18. ,387 1. 00 38. ,84 D c

ATOM 16291 OGl THR D 197 33. ,022 -35. 015 -16. ,999 1. 00 38. ,26 D 0

ATOM 16293 CG2 THR D 197 31. ,590 -34. ,193 -18. ,761 1. 00 39. ,70 D c

ATOM 16297 C THR D 197 31. ,900 -36. 750 -20. ,139 1. 00 37. ,89 D c

ATOM 16298 O THR D 197 32. ,755 -36. ,762 -21. 022 1. 00 33. 38 D 0

ATOM 16300 N HIS D 198 30. ,598 -36. 834 -20. 394 1. 00 39. ,44 D N

ATOM 16301 CA HIS D 198 30. ,074 -36. 974 -21. ,748 1. 00 38. ,43 D c

ATOM 16303 CB HIS D 198 30. 194 -38. 443 -22. ,199 1. 00 37. 37 D c

ATOM 16306 CG HIS D 198 29. ,631 -38. ,721 -23. ,564 1. 00 35. ,05 D c

ATOM 16307 NDl HIS D 198 30. ,320 -38. ,455 -24. ,729 1. 00 32. ,61 D N

ATOM 16309 CEl HIS D 198 29. ,580 -38. 807 -25. ,763 1. 00 31.14 D c

ATOM 16311 NE2 HIS D 198 28. ,439 -39. 297 -25. ,314 1. 00 33. ,29 D N

ATOM 16313 CD2 HIS D 198 28. ,452 -39. 264 -23. ,941 1. 00 33. ,34 D c

ATOM 16315 C HIS D 198 28. ,623 -36. 474 -21. ,793 1. 00 41. ,74 D c

ATOM 16316 O HIS D 198 27. ,922 -36. ,476 -20. ,769 1. 00 38. ,95 D 0

ATOM 16318 N GLN D 199 28. ,191 -36. ,030 -22. ,974 1. 00 43. ,67 D N

ATOM 16319 CA GLN D 199 26. ,853 -35. 463 -23. ,160 1. 00 43. ,93 D c

ATOM 16321 CB GLN D 199 26. ,648 -35. ,061 -24, ,627 1. 00 46. ,28 D c

ATOM 16324 CG GLN D 199 25. ,225 -34. ,605 -24. ,954 1. 00 48. ,17 D c

ATOM 16327 CD GLN D 199 25. ,081 -34. ,033 -26. ,347 1. 00 50. ,85 D c

ATOM 16328 OEl GLN D 199 26. ,046 -33. ,967 -27. ,115 1. 00 54. ,41 D 0

ATOM 16329 NE2 GLN D 199 23. ,860 -33. ,620 -26. ,687 1. 00 54. 51 D N

ATOM 16332 C GLN D 199 25. ,738 -36. ,413 -22. ,714 1. 00 43. ,84 D c

ATOM 16333 O GLN D 199 24. ,764 -35. ,983 -22. ,106 1. 00 48. ,58 D 0

ATOM 16335 N GLY D 200 25, ,888 -37. .699 -23, ,021 1. 00 42. ,80 D N

ATOM 16336 CA GLY D 200 24. ,913 -38. ,732 -22, .645 1. 00 41. ,96 D C

ATOM 16339 C GLY D 200 24. ,961 -39. ,217 -21. .205 1. 00 40. ,62 D C

ATOM 16340 O GLY D 200 24, ,310 -40. ,206 -20. ,865 1. 00 38. ,70 D 0

ATOM 16342 N LEU D 201 25. .741 -38. ,532 -20. ,368 1. 00 42. ,21 D N

ATOM 16343 CA LEU D 201 25. ,808 -38. ,803 -18, ,937 1. 00 41. ,75 D c

ATOM 16345 CB LEU D 201 27. ,255 -39. ,068 -18. ,508 1. 00 35. ,33 D c

ATOM 16348 CG LEU D 201 27. ,876 -40. ,399 -18. ,933 1. 00 30. ,90 D c

ATOM 16350 CDl LEU D 201 29, ,348 -40. ,445 -18, .555 1. 00 24. ,45 D c

ATOM 16354 CD2 LEU D 201 27, .123 -41. ,586 -18, .339 1. 00 31. ,71 D c

ATOM 16358 C LEU D 201 25, .263 -37. ,590 -18, .182 1. 00 46. ,14 D c

ATOM 16359 O LEU D 201 25, .722 -36. ,464 -18, ,403 1. 00 46. ,98 D 0

ATOM 16361 N SER D 202 24. .288 -37. ,827 -17, .297 1. 00 48. ,27 D N

ATOM 16362 CA SER D 202 23. ,693 -36. ,763 -16, .476 1. 00 49. ,04 D c

ATOM 16364 CB SER D 202 22. ,461 -37. ,278 -15. ,713 1. 00 51. ,12 D c cyno fD_Fab

ATOM 16367 OG SER D 202 22. 714 -38. 523 -15. 078 1. 00 51. ,09 D 0

ATOM 16369 C SER D 202 24. 735 -36. 175 -15. 513 1. 00 50. 73 D C

ATOM 16370 O SER D 202 24. 909 -34. 957 -15. 440 1. 00 51. 01 D 0

ATOM 16372 N SER D 203 25. 428 -37. ,046 -14. 787 1. 00 49. 62 D N

ATOM 16373 CA SER D 203 26. 593 -36. ,641 -14. 004 1. 00 49. ,43 D C

ATOM 16375 CB SER D 203 26. 290 -36. 699 -12. 502 1. 00 50. 66 D c

ATOM 16378 OG SER D 203 25. 822 -37. 982 -12. 112 1. 00 51. 17 D 0

ATOM 16380 C SER D 203 27. 784 -37. 540 -14. 359 1. 00 49. ,42 D c

ATOM 16381 O SER D 203 27. 587 -38. 680 -14. 791 1. 00 51. ,11 D 0

ATOM 16383 N PRO D 204 29. 023 -37. 028 -14. 194 1. 00 47. 80 D N

ATOM 16384 CA PRO D 204 30. 223 -37. 823 -14. 468 1. 00 46. 13 D C

ATOM 16386 CB PRO D 204 31. 363 -36. 904 -14. 017 1. 00 45. 04 D C

ATOM 16389 CG PRO D 204 30. ,817 -35. 547 -14. 147 1. 00 45. 68 D c

ATOM 16392 CD PRO D 204 29. 373 -35. ,659 -13. 775 1. 00 46. ,28 D c

ATOM 16395 C PRO D 204 30. 292 -39. ,151 -13. 713 1. 00 46. ,65 D c

ATOM 16396 O PRO D 204 29. 969 -39. 208 -12. 523 1. 00 47. 98 D 0

ATOM 16397 N VAL D 205 30. 712 -40. 201 -14. ,418 1. 00 45. ,61 D N

ATOM 16398 CA VAL D 205 30. 868 -41. 535 -13. 847 1. 00 42. 96 D c

ATOM 16400 CB VAL D 205 30. 379 -42. 635 -14. 826 1. 00 45. 57 D c

ATOM 16402 CGI VAL D 205 30. 367 -44. 003 -14. 145 1. 00 47. 04 D c

ATOM 16406 CG2 VAL D 205 28. ,994 -42. 300 -15. 370 1. 00 47. 22 D c

ATOM 16410 C VAL D 205 32. 345 -41. 767 -13. 543 1. 00 42. 43 D c

ATOM 16411 O VAL D 205 33. 198 -41. 585 -14. 414 1. 00 40. 17 D 0

ATOM 16413 N THR D 206 32. 639 -42. ,146 -12. 298 1. 00 41. ,03 D N

ATOM 16414 CA THR D 206 33. 983 -42. ,532 -11. 895 1. 00 38. 54 D c

ATOM 16416 CB THR D 206 34. 381 -41. 909 -10. 533 1. 00 39. 58 D c

ATOM 16418 OGl THR D 206 34. 270 -40. 483 -10. 607 1. 00 41. 40 D 0

ATOM 16420 CG2 THR D 206 35. 811 -42. 271 -10. 161 1. 00 38. 33 D c

ATOM 16424 C THR D 206 34. 041 -44. 051 -11. 794 1. 00 35. 16 D c

ATOM 16425 O THR D 206 33. 097 -44. 693 -11. 324 1. 00 31.19 D 0

ATOM 16427 N LYS D 207 35. 141 -44. 612 -12. 282 1. 00 33. 94 D N

ATOM 16428 CA LYS D 207 35. 494 -45. 999 -12. 045 1. 00 34. 16 D c

ATOM 16430 CB LYS D 207 35. 602 -46. 792 -13. 351 1. 00 37. 15 D c

ATOM 16433 CG LYS D 207 34. 285 -46. 987 -14. 096 1. 00 37. ,18 D c

ATOM 16436 CD LYS D 207 33. 360 -47. ,969 -13. 373 1. 00 38. 88 D c

ATOM 16439 CE LYS D 207 32. 006 -48. 076 -14. 070 1. 00 39. ,50 D c

ATOM 16442 NZ LYS D 207 30. 967 -48. 701 -13. 215 1. 00 39. 35 D N

ATOM 16446 C LYS D 207 36. 833 -45. 945 -11. 342 1. 00 32. 99 D C

ATOM 16447 0 LYS D 207 37. 758 -45. 289 -11. 819 1. 00 28. 90 D 0

ATOM 16449 N SER D 208 36. 927 -46. 596 -10. 188 1. 00 32. 63 D N

ATOM 16450 CA SER D 208 38. 166 -46. 589 -9. 423 1. 00 34. 88 D C

ATOM 16452 CB SER D 208 38. 057 -45. 619 -8. 238 1. 00 35. 83 D C

ATOM 16455 OG SER D 208 36. 774 -45. 672 -7. 627 1. 00 37. 02 D 0

ATOM 16457 C SER D 208 38. 556 -47. ,982 -8. 946 1. 00 35. ,88 D C

ATOM 16458 O SER D 208 37. 736 -48. ,899 -8. 930 1. 00 37. ,55 D 0

ATOM 16460 N PHE D 209 39. 832 -48. ,134 -8. 597 1. 00 35. ,66 D N

ATOM 16461 CA PHE D 209 40. 308 -49. ,315 -7. 895 1. 00 34. ,47 D c

ATOM 16463 CB PHE D 209 40. 938 -50. ,320 -8. 859 1. 00 30. ,65 D c

ATOM 16466 CG PHE D 209 42. 191 -49. ,831 -9. 519 1. 00 29. ,51 D c

ATOM 16467 CDl PHE D 209 43. 409 -49. ,875 -8. 857 1. 00 29. ,10 D c

ATOM 16469 CEl PHE D 209 44. 572 -49. ,430 -9. ,470 1. 00 30. ,20 D c

ATOM 16471 cz PHE D 209 44. 525 -48. ,953 -10. 761 1. 00 29. ,49 D c

ATOM 16473 CE2 PHE D 209 43. 319 -48. ,917 -11. 435 1. 00 29. ,96 D c

ATOM 16475 CD2 PHE D 209 42. 160 -49. ,356 -10. 818 1. 00 29. ,38 D c

ATOM 16477 C PHE D 209 41. 306 -48. ,916 -6. 810 1. 00 37. ,09 D c

ATOM 16478 O PHE D 209 42. 036 -47. ,934 -6. 962 1. 00 39. ,98 D 0

ATOM 16480 N ASN D 210 41. 318 -49. ,681 -5. 720 1. 00 37. ,21 D N

ATOM 16481 CA ASN D 210 42. 311 -49. ,521 -4. 651 1. 00 34. ,25 D c

ATOM 16483 CB ASN D 210 41. 704 -49. ,888 -3. 304 1. 00 33. ,38 D c

ATOM 16486 CG ASN D 210 40. 571 -48. ,978 -2. 904 1. 00 33. ,17 D c

ATOM 16487 ODl ASN D 210 40. 398 -47. ,896 -3. 457 1. 00 33. ,54 D 0

ATOM 16488 ND2 ASN D 210 39. ,793 -49. ,411 -1. 920 1. 00 34. ,26 D N

ATOM 16491 C ASN D 210 43. 508 -50. ,420 -4. 934 1. 00 30. .44 D c

ATOM 16492 O ASN D 210 43. 351 -51. .630 -5. ,103 1. 00 28. .02 D 0

ATOM 16494 N ARG D 211 44. 699 -49. ,835 -4. ,990 1. 00 30. ,03 D N

ATOM 16495 CA ARG D 211 45. 892 -50. .582 -5. 377 1. 00 35. ,18 D c

ATOM 16497 CB ARG D 211 47. 103 -49. ,657 -5. 393 1. 00 33. ,25 D c

ATOM 16500 CG ARG D 211 48. 376 -50. ,345 -5. 845 1. 00 31.85 D c cyn fD_Fab

ATOM 16503 CD ARG D 211 49..564 -49. 417 -5. ,759 1.00 31. ,50 D C

ATOM 16506 NE ARG D 211 49. .639 -48. 772 -4. ,458 1.00 30. ,34 D N

ATOM 16508 CZ ARG D 211 49. .947 -49. 402 -3. ,325 1.00 30. 43 D C

ATOM 16509 NHl ARG D 211 50. .247 -50. 696 -3. ,320 1.00 29. 16 D N

ATOM 16512 NH2 ARG D 211 49. .972 -48. 722 -2. ,189 1.00 28. ,99 D N

ATOM 16515 C ARG D 211 46. .176 -51. 777 -4. ,456 1.00 41. ,18 D C

ATOM 16516 O ARG D 211 46. .447 -51. 600 -3. ,264 1.00 43. ,62 D 0

ATOM 16518 N GLY D 212 46. ,124 -52. 985 -5. ,019 1.00 45. 70 D N

ATOM 16519 CA GLY D 212 46. ,390 -54. 215 -4. ,263 1.00 45. 88 D C

ATOM 16522 C GLY D 212 45. ,244 -54. 612 -3. ,347 1.00 48. ,12 D C

ATOM 16523 O GLY D 212 45. ,450 -54. 831 -2. ,150 1.00 48. 60 D 0

ATOM 16525 N GLU D 213 44. ,038 -54. 699 -3. ,915 1.00 49. 33 D N

ATOM 16526 CA GLU D 213 42. ,822 -55. 053 -3. ,169 1.00 49. 58 D C

ATOM 16528 CB GLU D 213 42. ,228 -53. 815 -2. ,483 1.00 51. 00 D c

ATOM 16531 CG GLU D 213 43. ,007 -53. 338 -1. ,243 1.00 52. ,20 D c

ATOM 16534 CD GLU D 213 42. ,317 -52. 210 -0. ,485 1.00 50. 89 D c

ATOM 16535 OEl GLU D 213 41. ,126 -51. 939 -0. 755 1.00 52. 48 D 0

ATOM 16536 OE2 GLU D 213 42. ,974 -51. 588 0. 379 1.00 46. 68 D 0

ATOM 16537 C GLU D 213 41. ,757 -55. 688 -4. 069 1.00 48. ,61 D c

ATOM 16538 O GLU D 213 42. ,032 -56. 091 -5. ,201 1.00 45. 50 D 0

ATOM 16540 N GLU E 1 43. 361 -66. 395 -59. ,205 1.00 45. 81 E N

ATOM 16541 CA GLU E 1 43. ,110 -65. 205 -58. ,342 1.00 42. 61 E C

ATOM 16543 CB GLU E 1 43. ,050 -65. 629 -56. ,876 1.00 47. 52 E C

ATOM 16546 CG GLU E 1 42. ,731 -64. 499 -55. 890 1.00 50. ,47 E c

ATOM 16549 CD GLU E 1 43. ,429 -64. 670 -54. 529 1.00 54. 38 E c

ATOM 16550 OEl GLU E 1 43. ,597 -65. 826 -54. 060 1.00 59. 16 E 0

ATOM 16551 OE2 GLU E 1 43. ,814 -63. 638 -53. 928 1.00 58. 37 E 0

ATOM 16552 C GLU E 1 44. 240 -64. 207 -58. ,525 1.00 36. 60 E c

ATOM 16553 O GLU E 1 45. 401 -64. 573 -58. ,404 1.00 36. 70 E 0

ATOM 16557 N VAL E 2 43. 903 -62. 953 -58. ,817 1.00 34. 34 E N

ATOM 16558 CA VAL E 2 44. 896 -61. 878 -58. ,869 1.00 31. 82 E c

ATOM 16560 CB VAL E 2 44. ,314 -60. 623 -59. ,526 1.00 28. 68 E c

ATOM 16562 CGI VAL E 2 45. ,290 -59. 438 -59. 404 1.00 24. 69 E c

ATOM 16566 CG2 VAL E 2 43. ,993 -60. 927 -60. ,973 1.00 26. 92 E c

ATOM 16570 C VAL E 2 45. ,441 -61. 538 -57. ,471 1.00 31. 24 E c

ATOM 16571 O VAL E 2 44. ,677 -61. 246 -56. ,539 1.00 26. 34 E 0

ATOM 16573 N GLN E 3 46. ,763 -61. 607 -57. ,328 1.00 29. 40 E N

ATOM 16574 CA GLN E 3 47. ,428 -61. 205 -56. ,110 1.00 32. 39 E c

ATOM 16576 CB GLN E 3 48. 029 -62. 417 -55. ,402 1.00 37. ,61 E c

ATOM 16579 CG GLN E 3 47. ,121 -63. 080 -54. ,390 1.00 40. ,10 E c

ATOM 16582 CD GLN E 3 47. ,828 -64. 214 -53. ,667 1.00 44. ,10 E c

ATOM 16583 OEl GLN E 3 47. ,745 -65. 376 -54. ,080 1.00 45. 91 E 0

ATOM 16584 NE2 GLN E 3 48. ,565 -63. 875 -52. ,602 1.00 48. 83 E N

ATOM 16587 C GLN E 3 48. ,533 -60. 205 -56. ,391 1.00 30. ,41 E c

ATOM 16588 O GLN E 3 49. ,308 -60. 369 -57. ,342 1.00 26. ,65 E 0

ATOM 16590 N LEU E 4 48. ,576 -59. 171 -55. ,551 1.00 30. ,61 E N

ATOM 16591 CA LEU E 4 49. ,668 -58. 196 -55. ,491 1.00 28. ,61 E C

ATOM 16593 CB LEU E 4 49. ,167 -56. 791 -55. ,848 1.00 28. ,10 E C

ATOM 16596 CG LEU E 4 48. ,654 -56. 615 -57. ,281 1.00 29. 88 E C

ATOM 16598 CDl LEU E 4 48. ,294 -55. 192 -57. ,529 1.00 28. ,48 E c

ATOM 16602 CD2 LEU E 4 49. ,682 -57. 115 -58. ,307 1.00 27. ,51 E c

ATOM 16606 C LEU E 4 50. ,214 -58. 199 -54. ,070 1.00 26. ,28 E c

ATOM 16607 O LEU E 4 49. ,516 -57. 775 -53. ,155 1.00 26. .99 E 0

ATOM 16609 N VAL E 5 51. ,442 -58. 696 -53. ,884 1.00 24. ,82 E N

ATOM 16610 CA VAL E 5 52. ,037 -58. 824 -52. ,549 1.00 25. ,39 E c

ATOM 16612 CB VAL E 5 52. ,422 -60. 302 -52. ,212 1.00 28. ,03 E c

ATOM 16614 CGI VAL E 5 52. ,860 -60. 443 -50. ,734 1.00 23. ,12 E c

ATOM 16618 CG2 VAL E 5 51. ,253 -61. 242 -52. ,530 1.00 24. ,65 E c

ATOM 16622 C VAL E 5 53. ,248 -57. 901 -52. ,415 1.00 26. ,85 E c

ATOM 16623 0 VAL E 5 54. ,261 -58. 078 -53. ,085 1.00 29. ,63 E 0

ATOM 16625 N GLN E 6 53. ,120 -56. 899 -51. ,555 1.00 28. ,37 E N

ATOM 16626 CA GLN E 6 54. ,185 -55. 925 -51. ,348 1.00 26. ,85 E c

ATOM 16628 CB GLN E 6 53. ,602 -54. 535 -51.083 1.00 27. ,34 E C

ATOM 16631 CG GLN E 6 53. ,048 -53. 905 -52. ,318 1.00 23. ,89 E C

ATOM 16634 CD GLN E 6 52. ,471 -52. 539 -52. ,082 1.00 20. ,30 E C

ATOM 16635 OEl GLN E 6 51, ,270 -52. 373 -52. ,092 1.00 23. ,44 E 0

ATOM 16636 NE2 GLN E 6 53. ,320 -51. 558 -51. ,863 1.00 21. ,80 E N

ATOM 16639 C GLN E 6 55. ,129 -56. 302 -50. ,227 1.00 30. ,71 E C cyno fD_Fab

ATOM 16640 O GLN E 6 54 768 -57 050 -49 299 1.00 24. 90 E 0

ATOM 16642 N SER E 7 56 345 -55 762 -50 327 1.00 29. 21 E N

ATOM 16643 CA SER E 7 57 391 -56 046 -49 371 1.00 28. 15 E C

ATOM 16645 CB SER E 7 58 763 -55 600 -49 892 1.00 26. 60 E C

ATOM 16648 OG SER E 7 58 776 -54 229 -50 234 1.00 27. 79 E 0

ATOM 16650 C SER E 7 57 064 -55 383 -48 050 1.00 27. 88 E C

ATOM 16651 O SER E 7 56 200 -54 518 -47 972 1.00 29. 50 E 0

ATOM 16653 N GLY E 8 57 759 -55 818 -47 007 1.00 30. 06 E N

ATOM 16654 CA GLY E 8 57 426 -55 456 -45 642 1.00 26. 95 E c

ATOM 16657 C GLY E 8 57 803 -54 039 -45 282 1.00 28. 72 E c

ATOM 16658 0 GLY E 8 58 440 -53 334 -46 074 1.00 30. 52 E 0

ATOM 16660 N PRO E 9 57 397 -53 602 -44 079 1.00 29. 77 E N

ATOM 16661 CA PRO E 9 57 683 -52 241 -43 647 1.00 31.34 E C

ATOM 16663 CB PRO E 9 56 949 -52 118 -42 306 1.00 30. 32 E C

ATOM 16666 CG PRO E 9 56 641 -53 492 -41 874 1.00 27. 28 E c

ATOM 16669 CD PRO E 9 56 623 -54 362 -43 083 1.00 30. 08 E c

ATOM 16672 C PRO E 9 59 176 -52 007 -43 483 1.00 32. 24 E c

ATOM 16673 O PRO E 9 59 917 -52 941 -43 202 1.00 34. 90 E 0

ATOM 16674 N GLU E 10 59 593 -50 761 -43 683 1.00 33. 21 E N

ATOM 16675 CA GLU E 10 60 999 -50 379 -43 694 1.00 32. 14 E c

ATOM 16677 CB GLU E 10 61 408 -49 916 -45 101 1.00 33. 21 E c

ATOM 16680 CG GLU E 10 61 240 -50 975 -46 214 1.00 35. 14 E c

ATOM 16683 CD GLU E 10 62 501 -51 777 -46 501 1.00 34. 56 E c

ATOM 16684 OEl GLU E 10 63 442 -51 751 -45 690 1.00 32. 42 E 0

ATOM 16685 OE2 GLU E 10 62 555 -52 434 -47 561 1.00 38. 18 E 0

ATOM 16686 C GLU E 10 61 214 -49 242 -42 716 1.00 31. 38 E c

ATOM 16687 O GLU E 10 60 318 -48 446 -42 475 1.00 35. 40 E 0

ATOM 16689 N LEU E 11 62 400 -49 195 -42 124 1.00 31. 96 E N

ATOM 16690 CA LEU E 11 62 843 -48 035 -41 372 1.00 31.09 E c

ATOM 16692 CB LEU E 11 62 948 -48 352 -39 871 1.00 29. 38 E c

ATOM 16695 CG LEU E 11 63 606 -47 303 -38 960 1.00 29. 82 E c

ATOM 16697 CDl LEU E 11 62 813 -45 987 -38 918 1.00 26. 14 E c

ATOM 16701 CD2 LEU E 11 63 792 -47 878 -37 570 1.00 30. 98 E c

ATOM 16705 C LEU E 11 64 196 -47 655 -41 970 1.00 30. 59 E c

ATOM 16706 O LEU E 11 65 097 -48 491 -42 071 1.00 30. 89 E 0

ATOM 16708 N LYS E 12 64 322 -46 407 -42 393 1.00 26. 41 E N

ATOM 16709 CA LYS E 12 65 533 -45 944 -43 042 1.00 29. 62 E c

ATOM 16711 CB LYS E 12 65 310 -45 803 -44 552 1.00 29. 74 E c

ATOM 16714 CG LYS E 12 65 085 -47 121 -45 280 1.00 28. 86 E c

ATOM 16717 CD LYS E 12 66 384 -47 945 -45 438 1.00 31. 34 E c

ATOM 16720 CE LYS E 12 66 074 -49 311 -46 021 1.00 32. 85 E c

ATOM 16723 NZ LYS E 12 67 276 -50 055 -46 456 1.00 33. 76 E N

ATOM 16727 C LYS E 12 65 913 -44 611 -42 441 1.00 32. 39 E c

ATOM 16728 O LYS E 12 65 053 -43 881 -41 958 1.00 35. 52 E 0

ATOM 16730 N LYS E 13 67 202 -44 300 -42 461 1.00 35. 01 E N

ATOM 16731 CA LYS E 13 67 692 -43 053 -41 901 1.00 35 82 E c

ATOM 16733 CB LYS E 13 69 144 -43 208 -41 441 1.00 40 75 E c

ATOM 16736 CG LYS E 13 69 351 -44 308 -40 396 1.00 43 06 E c

ATOM 16739 CD LYS E 13 70 832 -44 533 -40 092 1.00 42 05 E c

ATOM 16742 CE LYS E 13 71 041 -45 559 -38 980 1.00 44. 10 E c

ATOM 16745 NZ LYS E 13 70 406 -45 124 -37 702 1.00 46. 88 E N

ATOM 16749 C LYS E 13 67 584 -41 982 -42 961 1.00 33. 75 E C

ATOM 16750 0 LYS E 13 67 642 -42 293 -44 152 1.00 34. 61 E 0

ATOM 16752 N PRO E 14 67 409 -40 716 -42 544 1.00 33. 41 E N

ATOM 16753 CA PRO E 14 67 418 -39 622 -43 516 1.00 33. 70 E C

ATOM 16755 CB PRO E 14 67 437 -38 369 -42 635 1.00 33. 84 E c

ATOM 16758 CG PRO E 14 66 805 -38 791 -41 355 1.00 32 05 E c

ATOM 16761 CD PRO E 14 67 160 -40.239 -41 171 1.00 32 78 E c

ATOM 16764 C PRO E 14 68 655 -39 680 -44 416 1.00 31.92 E c

ATOM 16765 0 PRO E 14 69 729 -40 006 -43 939 1.00 32 74 E 0

ATOM 16766 N GLY E 15 68 497 -39 400 -45 705 1.00 30 81 E N

ATOM 16767 CA GLY E 15 69 617 -39 467 -46 649 1.00 30 33 E c

ATOM 16770 C GLY E 15 69 744 -40 783 -47 397 1.00 27 88 E c

ATOM 16771 0 GLY E 15 70 218 -40 809 -48 531 1.00 30 77 E 0

ATOM 16773 N ALA E 16 69 304 -41 871 -46 771 1.00 27 56 E N

ATOM 16774 CA ALA E 16 69 387 -43 202 -47 360 1.00 27 98 E c

ATOM 16776 CB ALA E 16 69 060 -44 249 -46 305 1.00 29 11 E c

ATOM 16780 C ALA E 16 68 476 -43 383 -48 575 1.00 28 26 E c cyno fD_Fab

ATOM 16781 O ALA E 16 67. ,811 -42. 452 -49. 012 1.00 28. 42 E 0

ATOM 16783 N SER E 17 68. ,481 -44. 594 -49. 125 1.00 30. 36 E N

ATOM 16784 CA SER E 17 67. ,579 -44. 994 -50. 205 1.00 27. 43 E C

ATOM 16786 CB SER E 17 68. ,360 -45. 233 -51. ,498 1.00 28. 83 E C

ATOM 16789 OG SER E 17 68. 799 -44. 003 -52. ,047 1.00 30. 20 E 0

ATOM 16791 C SER E 17 66. ,838 -46. 268 -49. 806 1.00 25. 64 E C

ATOM 16792 O SER E 17 67. ,313 -47. 031 -48. ,984 1.00 23. 68 E 0

ATOM 16794 N VAL E 18 65. 665 -46. 478 -50. 391 1.00 25. 18 E N

ATOM 16795 CA VAL E 18 64. 846 -47. ,661 -50. ,124 1.00 23. 49 E C

ATOM 16797 CB VAL E 18 63. ,730 -47. 357 -49. ,077 1.00 21. 83 E C

ATOM 16799 CGI VAL E 18 62. 725 -46. 369 -49. ,643 1.00 16. 12 E C

ATOM 16803 CG2 VAL E 18 63. 057 -48. 640 -48. ,601 1.00 20. 09 E c

ATOM 16807 C VAL E 18 64. 214 -48. 110 -51. ,435 1.00 22. 97 E c

ATOM 16808 O VAL E 18 63. 906 -47. 289 -52. ,301 1.00 22. 32 E 0

ATOM 16810 N LYS E 19 64. 038 -49. 415 -51.578 1.00 24. 24 E N

ATOM 16811 CA LYS E 19 63. 450 -49. ,988 -52. ,775 1.00 25. 40 E c

ATOM 16813 CB LYS E 19 64. 520 -50. ,659 -53. ,603 1.00 29. 70 E c

ATOM 16816 CG LYS E 19 64. 102 -51.121 -54. ,969 1.00 27. 47 E c

ATOM 16819 CD LYS E 19 65. 254 -51. 967 -55. ,514 1.00 26. 94 E c

ATOM 16822 CE LYS E 19 64. 950 -52. 543 -56. ,859 1.00 27. 65 E c

ATOM 16825 NZ LYS E 19 65. 914 -53. 646 -57. ,171 1.00 22. 24 E N

ATOM 16829 C LYS E 19 62. 399 -50. 990 -52. ,353 1.00 24. 50 E c

ATOM 16830 0 LYS E 19 62. 720 -52. 019 -51.767 1.00 25. 94 E 0

ATOM 16832 N VAL E 20 61. 145 -50. 660 -52. 661 1.00 23. 41 E N

ATOM 16833 CA VAL E 20 59. 961 -51. 418 -52. ,261 1.00 24. 90 E c

ATOM 16835 CB VAL E 20 58. 852 -50. 428 -51. ,790 1.00 28. 28 E c

ATOM 16837 CGI VAL E 20 57. 481 -51. 103 -51. ,680 1.00 31. 52 E c

ATOM 16841 CG2 VAL E 20 59. 269 -49. 800 -50. ,456 1.00 32. 24 E c

ATOM 16845 C VAL E 20 59. 486 -52. 236 -53. ,456 1.00 23. 66 E c

ATOM 16846 O VAL E 20 59. 491 -51. 739 -54. ,576 1.00 24. 78 E 0

ATOM 16848 N SER E 21 59. 101 -53. 492 -53. 223 1.00 25. 05 E N

ATOM 16849 CA SER E 21 58. 644 -54. 372 -54. 290 1.00 25. 66 E c

ATOM 16851 CB SER E 21 59. 462 -55. 671 -54. 307 1.00 32. 53 E c

ATOM 16854 OG SER E 21 59. 257 -56. ,459 -53. ,154 1.00 35. 58 E 0

ATOM 16856 C SER E 21 57. 124 -54. 655 -54. ,260 1.00 26. 81 E c

ATOM 16857 O SER E 21 56. 462 -54. 510 -53. 227 1.00 18. 48 E 0

ATOM 16859 N CYS E 22 56. 606 -55. 034 -55. 431 1.00 27. 56 E N

ATOM 16860 CA CYS E 22 55. 209 -55. 408 -55. 657 1.00 27. 74 E c

ATOM 16862 CB CYS E 22 54. 442 -54. 237 -56. ,304 1.00 30. 59 E c

ATOM 16865 SG CYS E 22 52. 649 -54. 540 -56. ,585 1.00 30. 39 E s

ATOM 16867 C CYS E 22 55. 165 -56. 638 -56. ,575 1.00 29. 21 E c

ATOM 16868 O CYS E 22 55. 279 -56. 521 -57. ,800 1.00 27. 90 E 0

ATOM 16870 N LYS E 23 55. 013 -57. 814 -55. .977 1.00 27. 07 E N

ATOM 16871 CA LYS E 23 54. 981 -59. ,080 -56. ,721 1.00 28. 97 E C

ATOM 16873 CB LYS E 23 55. 634 -60. ,196 -55. ,872 1.00 31. 05 E C

ATOM 16876 CG LYS E 23 55. 382 -61. 660 -56. 282 1.00 34. 03 E c

ATOM 16879 CD LYS E 23 56. 198 -62. 100 -57. ,489 1.00 37. ,11 E c

ATOM 16882 CE LYS E 23 56. 492 -63. 610 -57. ,475 1.00 38. 58 E c

ATOM 16885 NZ LYS E 23 57. 847 -63. 904 -56. ,934 1.00 41. 40 E N

ATOM 16889 C LYS E 23 53. 542 -59. 412 -57. ,175 1.00 30. 45 E c

ATOM 16890 O LYS E 23 52. 633 -59. 573 -56. ,355 1.00 34. 33 E 0

ATOM 16892 N ALA E 24 53. 359 -59. ,470 -58. ,496 1.00 27. 62 E N

ATOM 16893 CA ALA E 24 52. 092 -59. ,808 -59. ,141 1.00 25. 35 E C

ATOM 16895 CB ALA E 24 51. 952 -59. ,030 -60. ,454 1.00 20. 29 E C

ATOM 16899 C ALA E 24 52. Oil -61. 311 -59. ,420 1.00 22. 63 E C

ATOM 16900 O ALA E 24 53.023 -61. ,963 -59. ,662 1.00 24. 06 E 0

ATOM 16902 N SER E 25 50. 804 -61. 852 -59. ,368 1.00 23. ,69 E N

ATOM 16903 CA SER E 25 50. 538 -63. 231 -59. ,752 1.00 27. ,84 E C

ATOM 16905 CB SER E 25 50. 999 -64. ,241 -58. ,677 1.00 27. 33 E c

ATOM 16908 OG SER E 25 50. 230 -64. 142 -57. ,491 1.00 30. 87 E 0

ATOM 16910 C SER E 25 49. 049 -63. 385 -60. ,032 1.00 31. ,19 E c

ATOM 16911 0 SER E 25 48. 227 -62. ,533 -59. ,633 1.00 26. 98 E 0

ATOM 16913 N GLY E 26 48. 719 -64. ,468 -60. ,730 1.00 28. ,91 E N

ATOM 16914 CA GLY E 26 47. 350 -64. ,736 -61. ,146 1.00 28. ,96 E c

ATOM 16917 C GLY E 26 46. 894 -63. ,971 -62. ,376 1.00 31.23 E c

ATOM 16918 0 GLY E 26 45. 688 -63. ,893 -62. ,643 1.00 30. ,95 E 0

ATOM 16920 N TYR E 27 47. 839 -63. ,384 -63. 111 1.00 29. ,16 E N

ATOM 16921 CA TYR E 27 47. 529 -62. ,719 -64. ,376 1.00 28. ,01 E c cyno fD_Fab

ATOM 16923 CB TYR E 27 46 774 -61.393 -64. 142 1.00 28. ,84 E C

ATOM 16926 CG TYR E 27 47 628 -60. ,260 -63. 598 1.00 29. ,20 E C

ATOM 16927 CDl TYR E 27 48 219 -59. ,339 -64. 463 1.00 30. ,72 E C

ATOM 16929 CEl TYR E 27 48 998 -58. ,290 -63. 985 1.00 28. 44 E C

ATOM 16931 CZ TYR E 27 49 193 -58. ,151 -62. 635 1.00 26. ,00 E C

ATOM 16932 OH TYR E 27 49 977 -57. ,122 -62. 177 1.00 27. ,67 E 0

ATOM 16934 CE2 TYR E 27 48 605 -59. ,044 -61. 740 1.00 29. ,54 E C

ATOM 16936 CD2 TYR E 27 47 826 -60. ,090 -62. 226 1.00 27. ,82 E C

ATOM 16938 C TYR E 27 48 812 -62. ,481 -65. 175 1.00 27. ,01 E C

ATOM 16939 O TYR E 27 49 908 -62. ,523 -64. 614 1.00 25. ,37 E 0

ATOM 16941 N THR E 28 48. 673 -62. ,224 -66. 475 1.00 25. 48 E N

ATOM 16942 CA THR E 28 49. 827 -61. ,926 -67. 330 1.00 25. 80 E C

ATOM 16944 CB THR E 28 49 484 -62. ,069 -68. 826 1.00 27. ,75 E C

ATOM 16946 OGl THR E 28 48 834 -63. ,323 -69. 047 1.00 32. ,12 E 0

ATOM 16948 CG2 THR E 28 50 755 -62. ,006 -69. 699 1.00 23. 45 E C

ATOM 16952 C THR E 28 50 339 -60. ,512 -67. 019 1.00 22. 81 E C

ATOM 16953 O THR E 28 49 627 -59. ,524 -67. 176 1.00 21. ,44 E 0

ATOM 16955 N PHE E 29 51 587 -60. ,442 -66. 580 1.00 23. 28 E N

ATOM 16956 CA PHE E 29 52. 161 -59. ,244 -65. 980 1.00 26. 12 E C

ATOM 16958 CB PHE E 29 53. 540 -59. ,585 -65. 402 1.00 23. 11 E c

ATOM 16961 CG PHE E 29 54. 187 -58. ,462 -64. 643 1.00 22. 05 E c

ATOM 16962 CDl PHE E 29 53 619 -57. .989 -63. 457 1.00 18. ,67 E c

ATOM 16964 CEl PHE E 29 54 230 -56. ,959 -62. 745 1.00 20. ,45 E c

ATOM 16966 CZ PHE E 29 55 431 -56. ,412 -63. 199 1.00 21. 30 E c

ATOM 16968 CE2 PHE E 29 56 018 -56. 882 -64. 363 1.00 20. 28 E c

ATOM 16970 CD2 PHE E 29 55. 397 -57. 913 -65. 083 1.00 24. 32 E c

ATOM 16972 C PHE E 29 52. 241 -58. 078 -66. 968 1.00 25. 34 E c

ATOM 16973 O PHE E 29 51. 826 -56. ,974 -66. 653 1.00 26. 22 E 0

ATOM 16975 N THR E 30 52. 729 -58. ,341 -68. 174 1.00 22. 25 E N

ATOM 16976 CA THR E 30 52 874 -57. .297 -69. 179 1.00 21. ,54 E c

ATOM 16978 CB THR E 30 53 894 -57. ,706 -70. 242 1.00 19. ,16 E c

ATOM 16980 OGl THR E 30 53 457 -58. 903 -70. 896 1.00 27. ,04 E 0

ATOM 16982 CG2 THR E 30 55. 243 -57. ,933 -69. 600 1.00 14. ,18 E c

ATOM 16986 C THR E 30 51. 560 -56. ,859 -69. 851 1.00 25. ,42 E c

ATOM 16987 O THR E 30 51. 580 -55. 995 -70. 722 1.00 28. ,86 E 0

ATOM 16989 N ASN E 31 50. 433 -57. ,440 -69. 436 1.00 26. 85 E N

ATOM 16990 CA ASN E 31 49. 097 -57. ,071 -69. 946 1.00 25. 25 E c

ATOM 16992 CB ASN E 31 48 063 -58. .189 -69. 691 1.00 24. 62 E c

ATOM 16995 CG ASN E 31 48 048 -59. .262 -70. ,770 1.00 19. ,10 E c

ATOM 16996 ODl ASN E 31 49 030 -59. .483 -71. ,498 1.00 25. 22 E 0

ATOM 16997 ND2 ASN E 31 46 931 -59. ,971 -70. ,847 1.00 21. ,48 E N

ATOM 17000 C ASN E 31 48 551 -55. .808 -69. 322 1.00 23. ,41 E c

ATOM 17001 0 ASN E 31 47 741 -55. .120 -69. 934 1.00 26. ,09 E 0

ATOM 17003 N TYR E 32 48 981 -55. .533 -68. 094 1.00 22. ,97 E N

ATOM 17004 CA TYR E 32 48. 507 -54. ,415 -67. 300 1.00 22. ,74 E c

ATOM 17006 CB TYR E 32 47. 616 -54. .895 -66. ,149 1.00 21. .77 E c

ATOM 17009 CG TYR E 32 46 390 -55. ,733 -66. ,497 1.00 21. ,56 E c

ATOM 17010 CDl TYR E 32 45 114 -55. .170 -66. ,465 1.00 22. ,22 E c

ATOM 17012 CEl TYR E 32 43 999 -55. ,913 -66. ,755 1.00 20. ,44 E c

ATOM 17014 CZ TYR E 32 44 115 -57. ,256 -67. 050 1.00 22. ,11 E c

ATOM 17015 OH TYR E 32 42 959 -57. ,962 -67. 318 1.00 27. ,65 E 0

ATOM 17017 CE2 TYR E 32 45 361 -57. ,859 -67. 083 1.00 18. 79 E c

ATOM 17019 CD2 TYR E 32 46 495 -57. ,096 -66. 799 1.00 20. ,23 E c

ATOM 17021 C TYR E 32 49 698 -53. ,680 -66. ,685 1.00 22. ,46 E c

ATOM 17022 0 TYR E 32 50 644 -54. .306 -66. 212 1.00 25. ,60 E 0

ATOM 17024 N GLY E 33 49 637 -52. .354 -66. ,669 1.00 22. ,53 E N

ATOM 17025 CA GLY E 33 50 670 -51, .553 -66. ,038 1.00 24. ,09 E c

ATOM 17028 C GLY E 33 50 424 -51. .446 -64. ,552 1.00 21. ,45 E c

ATOM 17029 0 GLY E 33 49 420 -51. ,946 -64. ,047 1.00 21. ,24 E 0

ATOM 17031 N MET E 34 51 350 -50. .809 -63. ,841 1.00 22. 33 E N

ATOM 17032 CA MET E 34 51.218 -50, .642 -62. 390 1.00 24. ,25 E c

ATOM 17034 CB MET E 34 52 331 -51. ,385 -61. ,674 1.00 21.45 E c

ATOM 17037 CG MET E 34 52 103 -51. .671 -60. ,200 1.00 23. ,10 E c

ATOM 17040 SD MET E 34 50 995 -53. .059 -59. ,916 1.00 28. ,20 E s

ATOM 17041 CE MET E 34 51 880 -54. .403 -60. .693 1.00 22. ,31 E c

ATOM 17045 C MET E 34 51 286 -49, .167 -62. ,030 1.00 23. ,22 E c

ATOM 17046 0 MET E 34 52 174 -48, .448 -62. ,501 1.00 23. .65 E 0

ATOM 17048 N ASN E 35 50 350 -48, .735 -61. ,192 1.00 19. ,83 E N cyno fD_Fab

ATOM 17049 CA ASN E 35 50. 388 -47. 411 -60. 593 1. 00 21. 90 E C

ATOM 17051 CB ASN E 35 48. ,994 -46. 811 -60. 390 1. 00 23. 06 E C

ATOM 17054 CG ASN E 35 48. ,145 -46. 795 -61. 634 1. 00 26. 53 E c

ATOM 17055 ODl ASN E 35 48. ,634 -46. 656 -62. 761 1. 00 23. 14 E 0

ATOM 17056 ND2 ASN E 35 46. ,833 -46. 890 -61. 422 1. 00 22. 83 E N

ATOM 17059 C ASN E 35 50. ,987 -47. 512 -59. 200 1. 00 23. 59 E c

ATOM 17060 O ASN E 35 50. ,859 -48. 526 -58. 516 1. 00 23. 35 E 0

ATOM 17062 N TRP E 36 51. ,588 -46. 418 -58. 767 1. 00 23. 35 E N

ATOM 17063 CA TRP E 36 52. ,098 -46. 296 -57. 431 1. 00 21. 65 E c

ATOM 17065 CB TRP E 36 53. ,602 -46. 036 -57. 507 1. 00 21. 09 E c

ATOM 17068 CG TRP E 36 54. 338 -47. 296 -57. 797 1. 00 23. 40 E c

ATOM 17069 CDl TRP E 36 54. 787 -47. 734 -59. 013 1. 00 21. 20 E c

ATOM 17071 NEl TRP E 36 55. ,402 -48. 944 -58. 866 1. 00 21. 95 E N

ATOM 17073 CE2 TRP E 36 55. 351 -49. 317 -57. 548 1. 00 20. 18 E c

ATOM 17074 CD2 TRP E 36 54. 682 -48. 308 -56. 851 1. 00 20. 25 E c

ATOM 17075 CE3 TRP E 36 54. ,492 -48. 451 -55. 473 1. 00 22. 82 E c

ATOM 17077 CZ3 TRP E 36 54. 985 -49. 587 -54. 851 1. 00 21. 22 E c

ATOM 17079 CH2 TRP E 36 55. 631 -50. 573 -55. 573 1. 00 21. 59 E c

ATOM 17081 CZ2 TRP E 36 55. 830 -50. 462 -56. 920 1. 00 23. 19 E c

ATOM 17083 C TRP E 36 51.383 -45. 155 -56. 770 1. 00 13. 93 E c

ATOM 17084 O TRP E 36 51. ,215 -44. 129 -57. 372 1. 00 13. 75 E 0

ATOM 17086 N VAL E 37 50. 993 -45. 331 -55. 517 1. 00 24. 14 E N

ATOM 17087 CA VAL E 37 50. 160 -44. 379 -54. 813 1. 00 19. 31 E c

ATOM 17089 CB VAL E 37 48. 688 -44. 905 -54. 736 1. 00 21. 14 E c

ATOM 17091 CGI VAL E 37 47. 787 -43. 976 -53. 930 1. 00 15. 34 E c

ATOM 17095 CG2 VAL E 37 48. 110 -45. 143 -56. 136 1. 00 19. 69 E c

ATOM 17099 C VAL E 37 50. 714 -44. 223 -53. 399 1. 00 23. 73 E c

ATOM 17100 O VAL E 37 51. 084 -45. 213 -52. 787 1. 00 24. 89 E 0

ATOM 17102 N ARG E 38 50. 798 -42. 996 -52. 874 1. 00 23. 48 E N

ATOM 17103 CA ARG E 38 51. ,124 -42. 854 -51. 455 1. 00 25. 97 E c

ATOM 17105 CB ARG E 38 52. 496 -42. 213 -51. 211 1. 00 30. 87 E c

ATOM 17108 CG ARG E 38 52. ,584 -40. 738 -51.334 1. 00 30. 30 E c

ATOM 17111 CD ARG E 38 53. 907 -40. 251 -50. 710 1. 00 31. 62 E c

ATOM 17114 NE ARG E 38 53. 693 -39. 077 -49. 871 1. 00 35. 50 E N

ATOM 17116 CZ ARG E 38 54. 664 -38. 386 -49. 289 1. 00 41. 20 E c

ATOM 17117 NHl ARG E 38 55. 942 -38. 739 -49. 443 1. 00 45. 93 E N

ATOM 17120 NH2 ARG E 38 54. 352 -37. 336 -48. 542 1. 00 42. 14 E N

ATOM 17123 C ARG E 38 50. ,043 -42. 214 -50. 601 1. 00 20. 05 E C

ATOM 17124 0 ARG E 38 49. ,165 -41. 511 -51. ,088 1. 00 18. 25 E 0

ATOM 17126 N GLN E 39 50. ,097 -42. 553 -49. 325 1. 00 22. ,48 E N

ATOM 17127 CA GLN E 39 49. ,288 -41. 936 -48. 318 1. 00 25. ,55 E C

ATOM 17129 CB GLN E 39 48. ,101 -42. 832 -47. 993 1. 00 27. 38 E c

ATOM 17132 CG GLN E 39 47. ,147 -42. 288 -46. 958 1. 00 25. 90 E c

ATOM 17135 CD GLN E 39 45. 818 -42. 992 -47. 008 1. 00 23. ,35 E c

ATOM 17136 OEl GLN E 39 44. 769 -42. 363 -47. 161 1. 00 19. 77 E 0

ATOM 17137 NE2 GLN E 39 45. 855 -44. 307 -46. 943 1. 00 23. 35 E N

ATOM 17140 C GLN E 39 50. ,171 -41. 725 -47. 111 1. 00 26. ,42 E C

ATOM 17141 0 GLN E 39 50. 491 -42. ,671 -46. ,392 1. 00 27. ,02 E 0

ATOM 17143 N ALA E 40 50. 588 -40. 473 -46. 926 1. 00 28. 23 E N

ATOM 17144 CA ALA E 40 51. 276 -40. 040 -45. ,721 1. 00 27. ,90 E C

ATOM 17146 CB ALA E 40 51. ,707 -38. 576 -45. ,842 1. 00 26. ,11 E C

ATOM 17150 C ALA E 40 50. 324 -40. 220 -44. ,546 1. 00 30. ,93 E C

ATOM 17151 0 ALA E 40 49. 105 -40. 170 -44. ,723 1. 00 29. ,79 E 0

ATOM 17153 N PRO E 41 50. 861 -40. 425 -43. ,334 1. 00 33. ,06 E N

ATOM 17154 CA PRO E 41 49. ,964 -40. 724 -42. ,208 1. 00 34. ,14 E c

ATOM 17156 CB PRO E 41 50. ,923 -40. ,834 -41.019 1. 00 35. ,11 E c

ATOM 17159 CG PRO E 41 52. 213 -41. 228 -41. ,637 1. 00 35. ,80 E c

ATOM 17162 CD PRO E 41 52. 267 -40. ,432 -42. ,911 1. 00 33. ,95 E c

ATOM 17165 C PRO E 41 48. ,897 -39. ,670 -41. 945 1. 00 33. ,57 E c

ATOM 17166 0 PRO E 41 49. ,199 -38. ,477 -41. ,861 1. 00 38. ,62 E 0

ATOM 17167 N GLY E 42 47. ,651 -40. 122 -41.834 1. 00 32. ,79 E N

ATOM 17168 CA GLY E 42 46. ,521 -39. 237 -41.625 1. 00 32. ,77 E c

ATOM 17171 C GLY E 42 46. ,112 -38. 361 -42. ,808 1. 00 33. ,41 E c

ATOM 17172 0 GLY E 42 45. ,282 -37. ,469 -42. ,651 1. 00 31. ,00 E 0

ATOM 17174 N GLN E 43 46. ,662 -38. ,620 -43. ,992 1. 00 36. ,03 E H

ATOM 17175 CA GLN E 43 46. ,466 -37. 728 -45. ,142 1. 00 30. ,29 E c

ATOM 17177 CB GLN E 43 47. ,809 -37. 172 -45. 624 1. 00 30. ,92 E c

ATOM 17180 CG GLN E 43 48. ,561 -36. 362 -44. ,593 1. 00 37. .04 E c cyno fD..Fab

ATOM 17183 CD GLN E 43 47. ,795 -35. 120 -44. 160 1. 00 43. 95 E C

ATOM 17184 OEl GLN E 43 47. 280 -34. 363 -44. 995 1. 00 47. 10 E 0

ATOM 17185 NE2 GLN E 43 47. ,712 -34. 905 -42. 850 1. 00 47. 30 E N

ATOM 17188 C GLN E 43 45. ,760 -38. 465 -46. 258 1. 00 27. 09 E C

ATOM 17189 O GLN E 43 45. ,394 -39. ,634 -46. 114 1. 00 28. 47 E 0

ATOM 17191 N GLY E 44 45. ,559 -37. ,779 -47. 376 1. 00 24. 18 E N

ATOM 17192 CA GLY E 44 44. ,814 -38. 334 -48. 475 1. 00 23. 65 E C

ATOM 17195 C GLY E 44 45. ,683 -39. 156 -49. 388 1. 00 18. 02 E C

ATOM 17196 0 GLY E 44 46. ,886 -39. 215 -49. 216 1. 00 25. 49 E 0

ATOM 17198 N LEU E 45 45. ,062 -39. 796 -50. 366 1. 00 25. 41 E N

ATOM 17199 CA LEU E 45 45. ,793 -40. 592 -51. 359 1. 00 21. 76 E c

ATOM 17201 CB LEU E 45 44. ,837 -41. 524 -52. 089 1. 00 23. 56 E c

ATOM 17204 CG LEU E 45 44. ,041 -42. 528 -51. 286 1. 00 21.92 E c

ATOM 17206 CDl LEU E 45 43. ,184 -43. 335 -52. 254 1. 00 20. 25 E c

ATOM 17210 CD2 LEU E 45 44. ,978 -43. ,437 -50. 460 1. 00 22. 71 E c

ATOM 17214 C LEU E 45 46. ,444 -39. 677 -52. 401 1. 00 23. 48 E c

ATOM 17215 O LEU E 45 45. ,815 -38. 703 -52. 847 1. 00 24. 51 E 0

ATOM 17217 N GLU E 46 47. 677 -40. 004 -52. 811 1. 00 24. 62 E N

ATOM 17218 CA GLU E 46 48. 343 -39. 283 -53. 888 1. 00 21. 46 E c

ATOM 17220 CB GLU E 46 49. 529 -38. 471 -53. 371 1. 00 26. 40 E c

ATOM 17223 CG GLU E 46 49. ,315 -37. 731 -52. 087 1. 00 27. 56 E c

ATOM 17226 CD GLU E 46 50. 616 -37. 256 -51.506 1. 00 26. 92 E c

ATOM 17227 OEl GLU E 46 51.028 -37. 779 -50. 439 1. 00 26. 86 E 0

ATOM 17228 OE2 GLU E 46 51. ,234 -36. 382 -52. 139 1. 00 33. 13 E 0

ATOM 17229 C GLU E 46 48. ,845 -40. ,237 -54. 959 1. 00 22. 53 E c

ATOM 17230 O GLU E 46 49. ,574 -41. 196 -54. 677 1. 00 25. 39 E 0

ATOM 17232 N TRP E 47 48. ,464 -39. 948 -56. 196 1. 00 20. 56 E N

ATOM 17233 CA TRP E 47 48. 877 -40. 727 -57. 332 1. 00 22. 88 E c

ATOM 17235 CB TRP E 47 47. ,914 -40. 492 -58. 482 1. 00 19. 92 E c

ATOM 17238 CG TRP E 47 47. ,919 -41. 560 -59. 509 1. 00 22. 88 E c

ATOM 17239 CDl TRP E 47 47. 227 -42. 725 -59. 473 1. 00 23. 12 E c

ATOM 17241 NEl TRP E 47 47. 464 -43. 443 -60. 603 1. 00 21. 42 E N

ATOM 17243 CE2 TRP E 47 48. 344 -42. 753 -61.395 1. 00 20. 09 E c

ATOM 17244 CD2 TRP E 47 48. ,656 -41. 565 -60. 732 1. 00 19. 46 E c

ATOM 17245 CE3 TRP E 47 49. ,540 -40. ,660 -61. 338 1. 00 24. 78 E c

ATOM 17247 CZ3 TRP E 47 50. ,070 -40. ,984 -62. 563 1. 00 21.36 E c

ATOM 17249 CH2 TRP E 47 49. ,727 -42. ,180 -63. 204 1. 00 20. 75 E c

ATOM 17251 CZ2 TRP E 47 48. 875 -43. ,077 -62. 639 1. 00 17. 71 E c

ATOM 17253 C TRP E 47 50. ,296 -40. ,295 -57. 714 1. 00 25. 90 E c

ATOM 17254 0 TRP E 47 50. 532 -39. ,118 -58. 021 1. 00 23. 94 E 0

ATOM 17256 N MET E 48 51. 226 -41. 253 -57. 673 1. 00 28. 23 E N

ATOM 17257 CA MET E 48 52. ,654 -40. 988 -57. 889 1. 00 24. 20 E c

ATOM 17259 CB MET E 48 53. 497 -41. 927 -57. 066 1. 00 18. 65 E c

ATOM 17262 CG MET E 48 53. ,302 -41. ,774 -55. 601 1. 00 18. ,43 E c

ATOM 17265 SD MET E 48 54. ,150 -43. ,057 -54. 704 1. 00 19. 60 E s

ATOM 17266 CE MET E 48 55. ,843 -42. ,529 -54. 858 1. 00 21. 52 E c

ATOM 17270 C MET E 48 53. ,067 -41.137 -59. 321 1. 00 22. ,49 E c

ATOM 17271 0 MET E 48 53. ,886 -40. ,366 -59. ,811 1. 00 28. 41 E 0

ATOM 17273 N GLY E 49 52. ,496 -42. ,125 -59. 999 1. 00 18. 39 E N

ATOM 17274 CA GLY E 49 52. ,833 -42. ,369 -61.379 1. 00 16. 32 E c

ATOM 17277 C GLY E 49 52. ,551 -43. ,769 -61. 873 1. 00 16. 96 E c

ATOM 17278 0 GLY E 49 52. Oil -44. ,596 -61. 169 1. 00 16. 68 E 0

ATOM 17280 N TRP E 50 52. ,940 -44. ,023 -63. ,109 1. 00 20. ,14 E N

ATOM 17281 CA TRP E 50 52. .658 -45. ,275 -63. ,770 1. 00 16. ,94 E c

ATOM 17283 CB TRP E 50 51. ,606 -45. ,005 -64. ,838 1. 00 22. 28 E c

ATOM 17286 CG TRP E 50 51.749 -45. 628 -66. ,186 1. 00 19. ,14 E c

ATOM 17287 CDl TRP E 50 52. 587 -45. 230 -67. ,204 1. 00 23. 36 E c

ATOM 17289 NEl TRP E 50 52. 409 -46. 029 -68. ,314 1. 00 21. ,05 E N

ATOM 17291 CE2 TRP E 50 51. 422 -46. 941 -68. ,030 1. 00 25. ,78 E c

ATOM 17292 CD2 TRP E 50 50. ,997 -46. ,716 -66. ,689 1. 00 18. ,07 E c

ATOM 17293 CE3 TRP E 50 50. ,012 -47. 538 -66. ,147 1. 00 21. ,64 E c

ATOM 17295 CZ3 TRP E 50 49. ,477 -48. ,522 -66. ,927 1. 00 22. ,09 E c

ATOM 17297 CH2 TRP E 50 49. ,919 -48. ,734 -68. ,254 1. 00 21. ,99 E c

ATOM 17299 CZ2 TRP E 50 50. ,896 -47. ,966 -68. ,814 1. 00 20. ,34 E c

ATOM 17301 C TRP E 50 53. ,942 -45. ,808 -64. ,349 1. 00 24. ,10 E c

ATOM 17302 0 TRP E 50 54. ,761 -45. ,036 -64. ,838 1. 00 26. ,64 E 0

ATOM 17304 N ILE E 51 54. ,130 -47. ,124 -64. ,257 1. 00 20. ,65 E N

ATOM 17305 CA ILE E 51 55. 096 -47. ,804 -65. ,084 1. 00 22. ,17 E c cyno fD_ .Fab

ATOM 17307 CB ILE E 51 56..169 -48. 589 -64. 275 1.00 20. 11 E C

ATOM 17309 CGI ILE E 51 57. ,199 -49. 209 -65. 239 1.00 22. 02 E C

ATOM 17312 CDl ILE E 51 58. ,602 -49. 424 -64. 664 1.00 18. 26 E c

ATOM 17316 CG2 ILE E 51 55. ,512 -49. 601 -63. 313 1.00 13. 25 E c

ATOM 17320 C ILE E 51 54. ,344 -48. 731 -66. 041 1.00 25. 20 E c

ATOM 17321 O ILE E 51 53. ,393 -49. 443 -65. 646 1.00 22. 52 E 0

ATOM 17323 N ASN E 52 54. ,756 -48. 672 -67. 308 1.00 16. ,52 E N

ATOM 17324 CA ASN E 52 54. ,278 -49. 583 -68. 328 1.00 16. 49 E c

ATOM 17326 CB ASN E 52 54. ,443 -48. 924 -69. 703 1.00 14. 19 E c

ATOM 17329 CG ASN E 52 53. ,823 -49. 740 -70. 834 1.00 18. 18 E c

ATOM 17330 ODl ASN E 52 53. ,946 -50. 973 -70. 887 1.00 21.43 E 0

ATOM 17331 ND2 ASN E 52 53. ,171 -49. 052 -71. 752 1.00 20. 18 E N

ATOM 17334 C ASN E 52 55. ,094 -50. 872 -68. 196 1.00 18. 87 E c

ATOM 17335 O ASN E 52 56. ,325 -50. 875 -68. 407 1.00 19. 61 E 0

ATOM 17337 N THR E 53 54. ,424 -51. 951 -67. 786 1.00 16. ,17 E N

ATOM 17338 CA THR E 53 55. ,067 -53. 239 -67. 545 1.00 20. 06 E c

ATOM 17340 CB THR E 53 54. ,142 -54. 175 -66 . 736 1.00 16. 62 E c

ATOM 17342 OGl THR E 53 52. 935 -54. 333 -67. 465 1.00 18. 91 E 0

ATOM 17344 CG2 THR E 53 53. 810 -53. 612 -65. 298 1.00 10. 24 E c

ATOM 17348 C THR E 53 55. ,463 -53. 975 -68. 854 1.00 20. 76 E c

ATOM 17349 O THR E 53 56. ,186 -54. 977 -68. 799 1.00 24. 69 E 0

ATOM 17351 N TYR E 54 54. ,982 -53. 487 -70. 002 1.00 17. 95 E N

ATOM 17352 CA TYR E 54 55. ,283 -54. 067 -71. 311 1.00 19. 27 E c

ATOM 17354 CB TYR E 54 54. 082 -53. 979 -72. 287 1.00 17. 85 E c

ATOM 17357 CG TYR E 54 54. 267 -54. 864 -73. 507 1.00 17. ,18 E c

ATOM 17358 CDl TYR E 54 53. ,686 -56. 123 -73. 575 1.00 19. 27 E c

ATOM 17360 CE1 TYR E 54 53. 868 -56. 940 -74. 684 1.00 21. 16 E c

ATOM 17362 CZ TYR E 54 54. 667 -56. 517 -75. 738 1.00 20. 33 E c

ATOM 17363 OH TYR E 54 54. ,852 -57. 331 -76. 821 1.00 18. 54 E 0

ATOM 17365 CE2 TYR E 54 55. 266 -55. 278 -75. 695 1.00 19. 97 E c

ATOM 17367 CD2 TYR E 54 55. ,051 -54. 452 -74. 578 1.00 11.76 E c

ATOM 17369 C TYR E 54 56. 504 -53. 404 -71.938 1.00 21. 93 E c

ATOM 17370 O TYR E 54 57. 401 -54. 091 -72. 408 1.00 26. 66 E 0

ATOM 17372 N THR E 55 56. ,527 -52. 074 -71. 966 1.00 25. ,48 E N

ATOM 17373 CA THR E 55 57. ,607 -51.323 -72. 632 1.00 23. 25 E c

ATOM 17375 CB THR E 55 57. ,024 -50. 145 -73. 403 1.00 23. 75 E c

ATOM 17377 OGl THR E 55 56. ,303 -49. 294 -72. 501 1.00 28. 13 E 0

ATOM 17379 CG2 THR E 55 56. ,071 -50. 657 -74. 500 1.00 18. ,72 E c

ATOM 17383 C THR E 55 58. ,677 -50. 798 -71. 665 1.00 26. 93 E c

ATOM 17384 O THR E 55 59. ,835 -50. 565 -72. 061 1.00 24. 82 E 0

ATOM 17386 N GLY E 56 58. ,297 -50. 641 -70. 398 1.00 19. 62 E N

ATOM 17387 CA GLY E 56 59. ,195 -50. 128 -69. 366 1.00 23. 63 E c

ATOM 17390 C GLY E 56 59. ,091 -48. 621 -69. 128 1.00 29. 02 E c

ATOM 17391 O GLY E 56 59. ,684 -48. 108 -68. 172 1.00 32. ,83 E 0

ATOM 17393 N GLU E 57 58. ,339 -47. 910 -69. 972 1.00 32. 68 E N

ATOM 17394 CA GLU E 57 58. ,235 -46. 452 -69. ,855 1.00 32. ,74 E c

ATOM 17396 CB GLU E 57 57. ,833 -45. 761 -71. ,182 1.00 33 . ,15 E c

ATOM 17399 CG GLU E 57 56. ,506 -46. 146 -71.813 1.00 41. 40 E c

ATOM 17402 CD GLU E 57 56. ,528 -46. 181 -73. 375 1.00 44. ,50 E c

ATOM 17403 OEl GLU E 57 57. ,399 -45. 541 -74. Oil 1.00 48. ,94 E 0

ATOM 17404 OE2 GLU E 57 55. ,652 -46. 862 -73. 965 1.00 46. ,71 E 0

ATOM 17405 C GLU E 57 57. ,363 -46. 013 -68. 676 1.00 30. ,95 E c

ATOM 17406 O GLU E 57 56. ,423 -46. 712 -68. ,251 1.00 29. ,34 E 0

ATOM 17408 N THR E 58 57. ,697 -44. 836 -68. ,159 1.00 28. ,93 E N

ATOM 17409 CA THR E 58 57. ,161 -44. 355 -66 . ,897 1.00 27. ,41 E C

ATOM 17411 CB THR E 58 58. ,257 -44. 334 -65. ,809 1.00 24. ,06 E C

ATOM 17413 OGl THR E 58 59. ,429 -43. 650 -66. ,290 1.00 27. ,56 E 0

ATOM 17415 CG2 THR E 58 58. ,640 -45. 716 -65. ,421 1.00 12. 88 E c

ATOM 17419 C THR E 58 56. ,607 -42. 958 -67. ,032 1.00 30. ,29 E c

ATOM 17420 O THR E 58 57. ,128 -42. 162 -67. ,811 1.00 30. ,14 E 0

ATOM 17422 N THR E 59 55. ,531 -42. 681 -66. ,284 1.00 30. ,56 E N

ATOM 17423 CA THR E 59 54. ,985 -41. 337 -66. ,117 1.00 28. ,91 E c

ATOM 17425 CB THR E 59 53. ,571 -41.198 -66. ,729 1.00 28. ,95 E c

ATOM 17427 OGl THR E 59 53. ,604 -41. 562 -68. ,107 1.00 30. ,42 E 0

ATOM 17429 CG2 THR E 59 53. ,054 -39. 786 - 66. ,616 1.00 29. ,89 E c

ATOM 17433 C THR E 59 54. ,897 -41.058 -64. ,619 1.00 31.92 E c

ATOM 17434 O THR E 59 54. ,336 -41. 853 -63. ,862 1.00 30. ,64 E 0

ATOM 17436 N TYR E 60 55. ,453 -39. 927 -64. ,204 1.00 29. ,29 E N cyno fD_Fab

ATOM 17437 CA TYR E 60 55. 396 -39. ,488 -62. 823 1.00 25. ,84 E C

ATOM 17439 CB TYR E 60 56. ,794 -39. ,131 -62. 353 1.00 25. ,55 E C

ATOM 17442 CG TYR E 60 57. 758 -40. 281 -62. 458 1.00 21. ,89 E C

ATOM 17443 CDl TYR E 60 57. ,861 -41. 201 -61. 435 1.00 24. ,18 E c

ATOM 17445 CEl TYR E 60 58. ,732 -42. 241 -61. 501 1.00 24. ,72 E c

ATOM 17447 cz TYR E 60 59. ,503 -42. 413 -62. 630 1.00 23. 01 E c

ATOM 17448 OH TYR E 60 60. 369 -43. 476 -62. 664 1.00 23. 68 E 0

ATOM 17450 CE2 TYR E 60 59. ,426 -41. ,517 -63. 672 1.00 21.19 E c

ATOM 17452 CD2 TYR E 60 58. 560 -40. 448 -63. 576 1.00 23. ,95 E c

ATOM 17454 C TYR E 60 54. ,510 -38. 265 -62. 694 1.00 26. ,44 E c

ATOM 17455 O TYR E 60 54. ,466 -37. 423 -63. 596 1.00 26. ,63 E 0

ATOM 17457 N ALA E 61 53. ,790 -38. ,182 -61. 577 1.00 25. ,75 E N

ATOM 17458 CA ALA E 61 53. ,054 -36. ,984 -61. 233 1.00 26. ,98 E c

ATOM 17460 CB ALA E 61 52. ,126 -37. 236 -60. 038 1.00 24. ,01 E c

ATOM 17464 C ALA E 61 54. ,099 -35. 929 -60. 906 1.00 24. ,46 E c

ATOM 17465 O ALA E 61 55. 210 -36. 269 -60. 548 1.00 20. 53 E 0

ATOM 17467 N ASP E 62 53. 758 -34. 653 -61. 055 1.00 28. 06 E N

ATOM 17468 CA ASP E 62 54. 733 -33. 570 -60. 829 1.00 27. 68 E c

ATOM 17470 CB ASP E 62 54. 089 -32. 186 -61.112 1.00 33. 85 E c

ATOM 17473 CG ASP E 62 53. 989 -31. 878 -62. 623 1.00 39. 86 E c

ATOM 17474 ODl ASP E 62 54. 999 -32. 047 -63. 348 1.00 49. ,52 E 0

ATOM 17475 OD2 ASP E 62 52. 913 -31. 469 -63. 101 1.00 41. ,29 E 0

ATOM 17476 C ASP E 62 55. ,416 -33. 609 -59. 452 1.00 27. ,74 E c

ATOM 17Λ77 O ASP E 62 56. 626 -33. 346 -59. 337 1.00 25. 00 E 0

ATOM 17479 N ASP E 63 54. ,669 -33. 961 -58. 410 1.00 24. 36 E N

ATOM 17480 CA ASP E 63 55. 237 -34. 014 -57. 049 1.00 25. 69 E c

ATOM 17482 CB ASP E 63 54. 116 -34. 126 -56. 012 1.00 35. 83 E c

ATOM 17485 CG ASP E 63 53. 297 -32. 839 -55. 869 1.00 37. 82 E c

ATOM 17486 ODl ASP E 63 53. 769 -31. 733 -56. 253 1.00 33. 55 E 0

ATOM 17487 OD2 ASP E 63 52. 174 -32. 958 -55. 340 1.00 39. 96 E 0

ATOM 17488 C ASP E 63 56. 234 -35. 164 -56. 796 1.00 30. 06 E c

ATOM 17489 O ASP E 63 56. 893 -35. 206 -55. 735 1.00 23. 42 E 0

ATOM 17491 N PHE E 64 56. 343 -36. 096 -57. 748 1.00 23. 74 E N

ATOM 17492 CA PHE E 64 57. 198 -37. ,264 -57. 580 1.00 26. 32 E C

ATOM 17494 CB PHE E 64 56. 328 -38. 502 -57. 490 1.00 20. 36 E C

ATOM 17497 CG PHE E 64 55. 487 -38. 507 -56. 282 1.00 19. ,04 E C

ATOM 17498 CDl PHE E 64 56. ,003 -38. 962 -55. 084 1.00 20. 13 E C

ATOM 17500 CEl PHE E 64 55. 254 -38. 921 -53. 950 1.00 22. 53 E c

ATOM 17502 CZ PHE E 64 53. 966 -38. 396 -53. 989 1.00 18. 73 E c

ATOM 17504 CE2 PHE E 64 53. 450 -37. 911 -55. 163 1.00 17. 94 E c

ATOM 17506 CD2 PHE E 64 54. 200 -37. ,955 -56. 306 1.00 20. 70 E c

ATOM 17508 C PHE E 64 58. 237 -37. ,402 -58. 668 1.00 24. 60 E c

ATOM 17509 O PHE E 64 58. 766 -38. ,483 -58. 891 1.00 33. 90 E 0

ATOM 17511 N LYS E 65 58. 533 -36. 300 -59. 341 1.00 29. 38 E N

ATOM 17512 CA LYS E 65 59. 609 -36. 284 -60. 316 1.00 33. 29 E c

ATOM 17514 CB LYS E 65 59. 334 -35. 234 -61. 394 1.00 35. 87 E c

ATOM 17517 CG LYS E 65 58. 084 -35. ,521 -62. 226 1.00 36. 19 E c

ATOM 17520 CD LYS E 65 57. ,727 -34. 347 -63. 127 1.00 36. ,57 E c

ATOM 17523 CE LYS E 65 57. Oil -34. ,800 -64. 387 1.00 35. 68 E c

ATOM 17526 NZ LYS E 65 56. 228 -33. 677 -64. 975 1.00 40. 68 E N

ATOM 17530 C LYS E 65 60. ,899 -35. ,977 -59. 569 1.00 31. ,57 E C

ATOM 17531 O LYS E 65 60. ,982 -34. ,979 -58. ,851 1.00 32. ,77 E 0

ATOM 17533 N GLY E 66 61. 884 -36. ,857 -59. 698 1.00 36. ,07 E N

ATOM 17534 CA GLY E 66 63. 224 -36. ,585 -59. 170 1.00 32. ,70 E C

ATOM 17537 C GLY E 66 63. 802 -37. ,665 -58. 289 1.00 29. 23 E C

ATOM 17538 O GLY E 66 64. 744 -38. ,347 -58. 684 1.00 33. 74 E 0

ATOM 17540 N ARG E 67 63. 275 -37. ,806 -57. 082 1.00 20. 61 E N

ATOM 17541 CA ARG E 67 63. 791 -38. ,805 -56. 155 1.00 25. 40 E c

ATOM 17543 CB ARG E 67 63. 706 -38. ,311 -54. ,713 1.00 23. ,13 E c

ATOM 17546 CG ARG E 67 64. ,315 -36. ,956 -54. ,508 1.00 26. ,67 E c

ATOM 17549 CD ARG E 67 64. ,396 -36. ,571 -53. ,041 1.00 26. ,08 E c

ATOM 17552 NE ARG E 67 63. ,073 -36. ,340 -52. ,463 1.00 25. 32 E N

ATOM 17554 CZ ARG E 67 62. ,444 -37. ,152 -51. 621 1.00 22. ,19 E c

ATOM 17555 NHl ARG E 67 62. ,993 -38. ,285 -51. ,226 1.00 23. ,36 E N

ATOM 17558 NH2 ARG E 67 61. ,242 -36. ,820 -51. ,181 1.00 25. ,96 E N

ATOM 17561 C ARG E 67 63. ,109 -40. ,175 -56. ,264 1.00 25. ,60 E C

ATOM 17562 0 ARG E 67 63. ,494 -41. ,100 -55. ,540 1.00 24. ,89 E 0

ATOM 17564 N PHE E 68 62. 132 -40. ,309 -57. ,170 1.00 27. ,13 E N cyrv fD_Fab

ATOM 17565 CA PHE E 68 61.286 -41. 518 -57. ,273 1.00 23. 54 E C

ATOM 17567 CB PHE E 68 59. ,804 -41.163 -57. 062 1.00 22. 48 E C

ATOM 17570 CG PHE E 68 59. ,522 -40. 523 -55. ,744 1.00 23. 93 E C

ATOM 17571 CDl PHE E 68 59. ,071 -41. 272 -54. ,677 1.00 25. 35 E C

ATOM 17573 CEl PHE E 68 58. ,829 -40. 677 -53. ,459 1.00 18. 46 E C

ATOM 17575 CZ PHE E 68 59. ,048 -39. 333 -53. ,297 1.00 20. 39 E C

ATOM 17577 CE2 PHE E 68 59. ,479 -38. 574 -54. ,346 1.00 22. 00 E c

ATOM 17579 CD 2 PHE E 68 59. ,713 -39. 162 -55. ,562 1.00 26. 97 E c

ATOM 17581 C PHE E 68 61. ,444 -42. 179 -58. ,625 1.00 23. 80 E c

ATOM 17582 0 PHE E 68 61. ,245 -41. 519 -59. ,655 1.00 20. 89 E 0

ATOM 17584 N VAL E 69 61. ,799 -43. 473 -58. ,619 1.00 26. 79 E N

ATOM 17585 CA VAL E 69 62. ,053 -44. 239 -59. ,845 1.00 21. 38 E c

ATOM 17587 CB VAL E 69 63. 554 -44. 462 -60. ,064 1.00 23. 11 E c

ATOM 17589 CGI VAL E 69 63. 790 -45. 183 -61. ,375 1.00 12. 41 E c

ATOM 17593 CG2 VAL E 69 64. ,277 -43. 142 -60. ,048 1.00 22. 42 E c

ATOM 17597 C VAL E 69 61. ,350 -45. 592 -59. ,861 1.00 20. 04 E c

ATOM 17598 0 VAL E 69 61. ,484 -46. 377 -58. ,928 1.00 18. 12 E 0

ATOM 17600 N PHE E 70 60. ,577 -45. 851 -60. ,915 1.00 18. 90 E N

ATOM 17601 CA PHE E 70 59. 922 -47. 146 -61. ,088 1.00 19. 62 E c

ATOM 17603 CB PHE E 70 58. 535 -47. 034 -61. ,751 1.00 19. 63 E c

ATOM 17606 CG PHE E 70 57. 622 -45. 995 -61. ,131 1.00 19. 70 E c

ATOM 17607 CDl PHE E 70 57. 538 -45. 840 -59. ,756 1.00 20. 68 E c

ATOM 17609 CEl PHE E 70 56. 696 -44. 865 -59. ,193 1.00 19. 59 E c

ATOM 17611 CZ PHE E 70 55. 932 -44. 052 -60. ,005 1.00 21. 53 E c

ATOM 17613 CE2 PHE E 70 56. ,004 -44. 209 -61. ,392 1.00 19. 33 E c

ATOM 17615 CD2 PHE E 70 56. 847 -45. 176 -61.937 1.00 18. 38 E c

ATOM 17617 C PHE E 70 60. 811 -48. 023 -61. 956 1.00 18. 55 E c

ATOM 17618 0 PHE E 70 61.389 -47. 543 -62. ,938 1.00 23. 45 E 0

ATOM 17620 N SER E 71 60. 910 -49. 299 -61. 589 1.00 16. 20 E N

ATOM 17621 CA SER E 71 61. 559 -50. 312 -62. 426 1.00 20. 12 E c

ATOM 17623 CB SER E 71 63. 018 -50. 509 -62. ,014 1.00 16. 10 E c

ATOM 17626 OG SER E 71 63. 108 -50. 686 -60. ,621 1.00 24. 00 E 0

ATOM 17628 C SER E 71 60. 784 -51. 620 -62. ,333 1.00 22. 37 E c

ATOM 17629 0 SER E 71 59. 823 -51. 724 -61. ,551 1.00 22. 67 E 0

ATOM 17631 N LEU E 72 61. ,191 -52. 590 -63. ,158 1.00 20. ,88 E N

ATOM 17632 CA LEU E 72 60. 559 -53. 904 -63. 253 1.00 17. 96 E c

ATOM 17634 CB LEU E 72 59. 894 -54. 064 -64. ,616 1.00 21. 62 E c

ATOM 17637 CG LEU E 72 58. 892 -52. 997 -65. ,021 1.00 17. 90 E c

ATOM 17639 CDl LEU E 72 58. 557 -53. 154 -66. ,481 1.00 13. 13 E c

ATOM 17643 CD2 LEU E 72 57. 675 -53. 082 -64. 123 1.00 24. 52 E c

ATOM 17647 C LEU E 72 61. 569 -55. 008 -63. ,154 1.00 21. 97 E c

ATOM 17648 0 LEU E 72 62. 710 -54. 819 -63. ,524 1.00 19. 71 E 0

ATOM 17650 N ASP E 73 61. ,146 -56. 159 -62. ,645 1.00 26. ,26 E N

ATOM 17651 CA ASP E 73 61. ,794 -57. 418 -62. ,985 1.00 27. ,11 E c

ATOM 17653 CB ASP E 73 62. ,525 -58. 059 -61. ,813 1.00 28. ,49 E c

ATOM 17656 CG ASP E 73 63. 470 -59. 175 -62. ,267 1.00 24. 66 E c

ATOM 17657 ODl ASP E 73 63. ,227 -59. 744 -63. ,347 1.00 22. ,38 E 0

ATOM 17658 OD2 ASP E 73 64. ,453 -59. 475 -61. ,564 1.00 25. ,32 E 0

ATOM 17659 C ASP E 73 60. 717 -58. 344 -63. ,538 1.00 29. ,33 E c

ATOM 17660 0 ASP E 73 60. 014 -59. 025 -62. ,805 1.00 29. ,91 E 0

ATOM 17662 N THR E 74 60. 618 -58. 353 -64. ,856 1.00 30. ,27 E N

ATOM 17663 CA THR E 74 59. 529 -59. 005 -65. ,551 1.00 32. 11 E c

ATOM 17665 CB THR E 74 59. ,524 -58. 542 -67. ,030 1.00 30. ,75 E c

ATOM 17667 OGl THR E 74 58. ,245 -58. 007 -67. ,347 1.00 35. 93 E 0

ATOM 17669 CG2 THR E 74 59. ,881 -59. 640 -67. ,974 1.00 30. 98 E c

ATOM 17673 C THR E 74 59. 582 -60. 537 -65. ,391 1.00 32. ,79 E c

ATOM 17674 0 THR E 74 58. ,545 -61. 203 -65. ,369 1.00 35. ,69 E 0

ATOM 17676 N SER E 75 60. 791 -61. 076 -65, ,245 1.00 36. ,20 E N

ATOM 17677 CA SER E 75 61. 002 -62. 506 -64. ,996 1.00 34. ,83 E c

ATOM 17679 CB SER E 75 62. 491 -62. 826 -65. ,091 1.00 35. ,55 E c

ATOM 17682 OG SER E 75 63. 159 -62. 364 -63. ,935 1.00 34. ,07 E 0

ATOM 17684 C SER E 75 60. ,476 -62. 997 -63. .632 1.00 37. ,76 E c

ATOM 17685 0 SER E 75 60. ,246 -64. ,194 -63. .451 1.00 35. ,12 E 0

ATOM 17687 N VAL E 76 60. ,321 -62. 080 -62. .673 1.00 35. ,85 E N

ATOM 17688 CA VAL E 76 59. 753 -62. 398 -61, ,359 1.00 31. ,84 E c

ATOM 17690 CB VAL E 76 60. 757 -62. 062 -60, ,242 1.00 32. ,64 E c

ATOM 17692 CGI VAL E 76 60. 120 -62. 161 -58, ,878 1.00 39. ,14 E c

ATOM 17696 CG2 VAL E 76 61. ,946 -63. 014 -60. ,323 1.00 35. ,23 E c cyno fD_Fab

ATOM 17700 C VAL E 76 58. ,436 -61. 635 -61. ,192 1.00 32. 03 E C

ATOM 17701 O VAL E 76 57. .901 -61. ,509 -60. ,088 1.00 30. 94 E 0

ATOM 17703 N SER E 77 57. .912 -61. ,163 -62. 322 1.00 28. 84 E N

ATOM 17704 CA SER E 77 56. .730 -60. ,330 -62. ,386 1.00 30. 11 E C

ATOM 17706 CB SER E 77 55. .490 -61.215 -62. 526 1.00 31. 53 E C

ATOM 17709 OG SER E 77 55. ,279 -61. 944 -61. 349 1.00 39. 14 E 0

ATOM 17711 C SER E 77 56. ,627 -59. 376 -61. ,194 1.00 25. 33 E C

ATOM 17712 O SER E 77 55. ,657 -59. 396 -60. 460 1.00 21.60 E 0

ATOM 17714 N THR E 78 57. ,661 -58. 556 -61. 009 1.00 26. 14 E N

ATOM 17715 CA THR E 78 57. ,737 -57. 612 -59. 886 1.00 25. 05 E c

ATOM 17717 CB THR E 78 58. ,844 -58. 038 -58. 880 1.00 24. 81 E c

ATOM 17719 OGl THR E 78 58. ,665 -59. ,407 -58. ,528 1.00 26. 63 E 0

ATOM 17721 CG2 THR E 78 58. ,823 -57. ,209 -57. ,607 1.00 19. 58 E c

ATOM 17725 C THR E 78 57. ,995 -56. 188 -60. ,401 1.00 23. 95 E c

ATOM 17726 O THR E 78 58. ,771 -55. 992 -61. ,335 1.00 22. 95 E 0

ATOM 17728 N ALA E 79 57. ,294 -55. 223 -59. 807 1.00 22. 50 E N

ATOM 17729 CA ALA E 79 57. ,521 -53. 799 -60. ,009 1.00 21.03 E c

ATOM 17731 CB ALA E 79 56. ,196 -53. 077 -60. 292 1.00 15. 40 E c

ATOM 17735 C ALA E 79 58. ,145 -53. 254 -58. ,742 1.00 20. 97 E c

ATOM 17736 O ALA E 79 57. ,826 -53. 714 -57. 642 1.00 20. 71 E 0

ATOM 17738 N TYR E 80 59. ,033 -52. 277 -58. 901 1.00 21.36 E N

ATOM 17739 CA TYR E 80 59. ,726 -51. 646 -57. 784 1.00 22. 23 E c

ATOM 17741 CB TYR E 80 61. 239 -51. 957 -57. 827 1.00 24. 92 E c

ATOM 17744 CG TYR E 80 61. ,554 -53. 413 -57. 885 1.00 21. 60 E c

ATOM 17745 CDl TYR E 80 61. ,659 -54. 162 -56. 719 1.00 24. 57 E c

ATOM 17747 CEl TYR E 80 61. 966 -55. 510 -56. 756 1.00 25. 85 E c

ATOM 17749 CZ TYR E 80 62. ,140 -56. 139 -57. ,978 1.00 26. 02 E c

ATOM 17750 OH TYR E 80 62. ,440 -57. 482 -57. 999 1.00 27. 13 E 0

ATOM 17752 CE2 TYR E 80 62. 035 -55. 421 -59. 162 1.00 23. 64 E c

ATOM 17754 CD2 TYR E 80 61. 743 -54. 059 -59. 109 1.00 24. 53 E c

ATOM 17756 C TYR E 80 59. ,581 -50. 145 -57. ,773 1.00 21. 55 E c

ATOM 17757 O TYR E 80 59. 479 -49. 492 -58. ,814 1.00 19. 84 E 0

ATOM 17759 N LEU E 81 59. ,596 -49. 602 -56. 564 1.00 24. 83 E N

ATOM 17760 CA LEU E 81 59. 677 -48. 173 -56. 368 1.00 23. 80 E c

ATOM 17762 CB LEU E 81 58. 448 -47. 641 -55. 624 1.00 23. 00 E c

ATOM 17765 CG LEU E 81 58. 463 -46. 204 -55. 077 1.00 20. 80 E c

ATOM 17767 CDl LEU E 81 58. 547 -45. 101 -56. 167 1.00 9. 61 E c

ATOM 17771 CD2 LEU E 81 57. 244 -46. 047 -54. 207 1.00 16. 24 E c

ATOM 17775 C LEU E 81 60. 932 -47. 942 -55. 572 1.00 21. 64 E c

ATOM 17776 O LEU E 81 61.082 -48. 463 -54. 485 1.00 23. 91 E 0

ATOM 17778 N GLN E 82 61. 856 -47. 195 -56. ,144 1.00 21. 13 E N

ATOM 17779 CA GLN E 82 63. ,016 -46. 754 -55. ,414 1.00 21. 41 E c

ATOM 17781 CB GLN E 82 64. 269 -46.995 -56. ,245 1.00 23. 14 E c

ATOM 17784 CG GLN E 82 65. ,551 -46. 727 -55. 528 1.00 22. 93 E c

ATOM 17787 CD GLN E 82 66. ,736 -47. 246 -56. 308 1.00 26. 57 E c

ATOM 17788 OEl GLN E 82 67. ,004 -48. 433 -56. ,304 1.00 23. 58 E 0

ATOM 17789 NE2 GLN E 82 67. ,438 -46. 354 -56. ,999 1.00 32. 14 E N

ATOM 17792 C GLN E 82 62. ,851 -45. 278 -55. ,072 1.00 16. 59 E c

ATOM 17793 O GLN E 82 62. ,543 -44. 466 -55. ,942 1.00 19. 82 E 0

ATOM 17795 N ILE E 83 63. ,016 -44. 950 -53. ,792 1.00 20. 99 E N

ATOM 17796 CA ILE E 83 63. 075 -43. 555 -53. ,330 1.00 21. 79 E c

ATOM 17798 CB ILE E 83 62. 039 -43. 230 -52. ,227 1.00 21. 02 E c

ATOM 17800 CGI ILE E 83 60. ,711 -43. 937 -52. ,484 1.00 19. 35 E c

ATOM 17803 CDl ILE E 83 59. ,667 -43. 716 -51. ,366 1.00 21. 19 E c

ATOM 17807 CG2 ILE E 83 61. ,839 -41. 713 -52. ,149 1.00 18. 89 E c

ATOM 17811 C ILE E 83 64. ,450 -43. ,210 -52. ,764 1.00 23. 74 E c

ATOM 17812 O ILE E 83 64. ,958 -43. ,894 -51. ,869 1.00 21. 30 E 0

ATOM 17814 N SER E 84 65. ,022 -42. ,116 -53. ,263 1.00 26. 69 E N

ATOM 17815 CA SER E 84 66. ,364 -41. ,678 -52. ,890 1.00 25. 06 E C

ATOM 17817 CB SER E 84 67. ,138 -41. ,311 -54. ,139 1.00 27. 73 E c

ATOM 17820 OG SER E 84 67. ,281 -42. ,450 -54. ,946 1.00 32. 86 E 0

ATOM 17822 C SER E 84 66. 333 -40. ,474 -51. ,981 1.00 25. ,62 E c

ATOM 17823 0 SER E 84 65. ,310 -39. 818 -51. ,868 1.00 27. 47 E 0

ATOM 17825 N SER E 85 67. ,467 -40. ,187 -51. ,340 1.00 28. 80 E N

ATOM 17826 CA SER E 85 67. ,618 -39. 008 -50. ,488 1.00 27. 22 E c

ATOM 17828 CB SER E 85 67. ,804 -37. 769 -51. ,353 1.00 30. 22 E c

ATOM 17831 OG SER E 85 68. ,946 -37. 920 -52. ,184 1.00 32. 28 E 0

ATOM 17833 C SER E 85 66. ,432 -38. 827 -49. ,541 1.00 27. 81 E c cyno fD_Fab

ATOM 17834 O SER E 85 65. .836 -37. 750 -49. ,465 1.00 24. ,90 E 0

ATOM 17836 N LEU E 86 66. ,120 -39. 899 -48. ,814 1.00 26. 51 E N

ATOM 17837 CA LEU E 86 64. .944 -39. 959 -47. ,951 1.00 29. 18 E C

ATOM 17839 CB LEU E 86 64. ,875 -41. 318 -47. ,246 1.00 29. 09 E C

ATOM 17842 CG LEU E 86 64. ,462 -42. 495 -48. ,138 1.00 25. 28 E c

ATOM 17844 CDl LEU E 86 64. ,699 -43. 803 -47. ,443 1.00 23. 42 E c

ATOM 17848 CD2 LEU E 86 63. ,003 -42. 386 -48. ,532 1.00 20. 35 E c

ATOM 17852 C LEU E 86 64. ,894 -38. 827 -46. ,931 1.00 30. ,66 E c

ATOM 17853 0 LEU E 86 65. ,899 -38. 488 -46. ,313 1.00 31. ,70 E 0

ATOM 17855 N LYS E 87 63. ,708 -38. 224 -46. ,815 1.00 33. ,24 E N

ATOM 17856 CA LYS E 87 63. ,401 -37. 172 -45. ,850 1.00 35. 49 E c

ATOM 17858 CB LYS E 87 62. ,763 -35. 957 -46. ,555 1.00 38. 89 E c

ATOM 17861 CG LYS E 87 63. ,598 -35. 378 -47. ,698 1.00 40. 14 E c

ATOM 17864 CD LYS E 87 62. ,825 -34. 392 -48. ,583 1.00 41. 06 E c

ATOM 17867 CE LYS E 87 63. ,761 -33. 806 -49. ,680 1.00 43. 26 E c

ATOM 17870 NZ LYS E 87 63. ,074 -32. 929 -50. ,697 1.00 41. 97 E N

ATOM 17874 C LYS E 87 62. ,397 -37. 775 -44. ,879 1.00 35. 49 E c

ATOM 17875 0 LYS E 87 61. ,723 -38. 745 -45. 217 1.00 35. 37 E 0

ATOM 17877 N ALA E 88 62. ,282 -37. 188 -43. 688 1.00 36. 11 E N

ATOM 17878 CA ALA E 88 61. ,264 -37. 595 -42. 701 1.00 33. 64 E c

ATOM 17880 CB ALA E 88 61. ,353 -36. 718 -41. ,444 1.00 29. ,97 E c

ATOM 17884 C ALA E 88 59. ,856 -37. 543 -43. 292 1.00 30. 38 E c

ATOM 17885 0 ALA E 88 59. ,009 -38. 356 -42. 947 1.00 27. 79 E 0

ATOM 17887 N GLU E 89 59. ,641 -36. 586 -44. ,194 1.00 33. 32 E N

ATOM 17888 CA GLU E 89 58. ,355 -36. 351 -44. 858 1.00 33. 72 E c

ATOM 17890 CB GLU E 89 58. ,381 -35. 018 -45. 613 1.00 38. 76 E c

ATOM 17893 CG GLU E 89 58. ,381 -33. 777 -44. 716 1.00 41.68 E c

ATOM 17896 CD GLU E 89 59. ,757 -33. 396 -44. 200 1.00 46. 63 E c

ATOM 17897 OEl GLU E 89 60. ,764 -33. 792 -44. 833 1.00 44. 32 E 0

ATOM 17898 OE2 GLU E 89 59. ,827 -32. 693 -43. 159 1.00 49. 77 E 0

ATOM 17899 C GLU E 89 57. ,953 -37. 442 -45. 849 1.00 34. 39 E c

ATOM 17900 0 GLU E 89 56. 794 -37. 489 -46. 272 1.00 31. 31 E 0

ATOM 17902 N ASP E 90 58. 913 -38. 285 -46. 240 1.00 31. 74 E N

ATOM 17903 CA ASP E 90 58. 628 -39. 465 -47. ,057 1.00 27. 31 E c

ATOM 17905 CB ASP E 90 59. ,884 -39. 973 -47. ,748 1.00 24. 96 E c

ATOM 17908 CG ASP E 90 60. ,421 -39. 005 -48. ,744 1.00 22. 36 E c

ATOM 17909 ODl ASP E 90 59. 625 -38. 292 -49. ,370 1.00 26. 32 E 0

ATOM 17910 002 ASP E 90 61. ,650 -38. 989 -48. ,934 1.00 26. 57 E 0

ATOM 17911 C ASP E 90 58. 027 -40. 605 -46. 256 1.00 22. 79 E c

ATOM 17912 0 ASP E 90 57. 652 -41.621 -46. ,837 1.00 25. 51 E 0

ATOM 17914 N THR E 91 57. 964 -40. 461 -44. ,936 1.00 23. 54 E N

ATOM 17915 CA THR E 91 57. 273 -41. 432 -44. 089 1.00 24. 73 E c

ATOM 17917 CB THR E 91 57. 300 -41. 025 -42. 592 1.00 26. 19 E c

ATOM 17919 OGl THR E 91 58. ,657 -40. 893 -42. 150 1.00 23. 99 E 0

ATOM 17921 CG2 THR E 91 56. ,569 -42. 051 -41.722 1.00 24. 19 E c

ATOM 17925 C THR E 91 55. ,829 -41. 524 -44. 557 1.00 26. 14 E c

ATOM 17926 0 THR E 91 55. 066 -40. 546 -44. ,481 1.00 26. ,53 E 0

ATOM 17928 N ALA E 92 55. ,471 -42. 697 -45. ,070 1.00 23. ,41 E N

ATOM 17929 CA ALA E 92 54. ,172 -42. 909 -45. ,676 1.00 20. 23 E C

ATOM 17931 CB ALA E 92 54. ,043 -42. 051 -46. ,945 1.00 18. ,83 E C

ATOM 17935 C ALA E 92 53. ,974 -44. 379 -46. ,016 1.00 17. ,50 E C

ATOM 17936 0 ALA E 92 54. 949 -45. 135 -46. ,095 1.00 21. ,47 E 0

ATOM 17938 N VAL E 93 52. ,715 -44. 767 -46. ,234 1.00 22. 88 E N

ATOM 17939 CA VAL E 93 52. ,374 -46. 033 -46. ,892 1.00 21. 18 E C

ATOM 17941 CB VAL E 93 50. 993 -46. 569 -46. ,457 1.00 20. 20 E C

ATOM 17943 CGI VAL E 93 50. ,676 -47. 864 -47. ,191 1.00 14. 16 E C

ATOM 17947 CG2 VAL E 93 50. ,955 -46. 805 -44. ,935 1.00 21. 20 E C

ATOM 17951 C VAL E 93 52. ,385 -45. 860 -48. ,422 1.00 23. 32 E C

ATOM 17952 0 VAL E 93 51. ,793 -44. 929 -48. ,960 1.00 23. ,78 E 0

ATOM 17954 N TYR E 94 53. ,063 -46. 771 -49. ,107 1.00 24. 98 E N

ATOM 17955 CA TYR E 94 53. ,184 -46. 757 -50. ,569 1.00 21.09 E C

ATOM 17957 CB TYR E 94 54. ,656 -46. 789 -50. ,981 1.00 18. ,31 E c

ATOM 17960 CG TYR E 94 55. ,393 -45. 546 -50. ,563 1.00 16. ,32 E c

ATOM 17961 CDl TYR E 94 55. ,510 -44. 469 -51. ,432 1.00 19. ,59 E c

ATOM 17963 CEl TYR E 94 56. ,152 -43. 308 -51. ,061 1.00 17. ,02 E c

ATOM 17965 CZ TYR E 94 56. ,703 -43. 201 -49. ,819 1.00 17. ,08 E c

ATOM 17966 OH TYR E 94 57. ,331 -42. 027 -49. ,512 1.00 21. ,17 E 0

ATOM 17968 CE2 TYR E 94 56. ,618 -44. 248 -48. ,916 1.00 16. ,36 E c cyno fD_Fab

ATOM 17970 CD2 TYR E 94 55. .966 -45. .432 -49. ,299 1. 00 18. 62 E C

ATOM 17972 C TYR E 94 52. 504 -47. ,994 -51. ,097 1. 00 21. 71 E C

ATOM 17973 O TYR E 94 52. ,835 -49. ,104 -50. ,674 1. 00 32. 23 E 0

ATOM 17975 N TYR E 95 51. 575 -47. ,802 -52. ,029 1. 00 23. 89 E N

ATOM 17976 CA TYR E 95 50. ,782 -48. ,886 -52. ,602 1. 00 23. 75 E C

ATOM 17978 CB TYR E 95 49. ,301 -48, .540 -52. ,553 1. 00 24. 60 E C

ATOM 17981 CG TYR E 95 48. ,684 -48, .400 -51, ,195 1. 00 25. 48 E C

ATOM 17982 CDl TYR E 95 48. ,298 -49. .528 -50. ,476 1. 00 22. 52 E C

ATOM 17984 CEl TYR E 95 47. ,677 -49. .409 -49. ,238 1. 00 25. 46 E C

ATOM 17986 CZ TYR E 95 47. ,434 -48. .158 -48. ,715 1. 00 25. 51 E C

ATOM 17987 OH TYR E 95 46. ,840 -48, ,079 -47. ,485 1. 00 28. 74 E 0

ATOM 17989 CE2 TYR E 95 47. ,794 -46. ,997 -49. ,419 1. 00 23. 62 E C

ATOM 17991 CD2 TYR E 95 48. ,400 -47. ,126 -50. 657 1. 00 26. 10 E c

ATOM 17993 C TYR E 95 51. ,078 -49. ,042 -54. 071 1. 00 22. 24 E c

ATOM 17994 0 TYR E 95 51. ,351 -48. ,074 -54. 759 1. 00 24. 85 E 0

ATOM 17996 N CYS E 96 50. 953 -50, .260 -54. ,553 1. 00 24. 35 E N

ATOM 17997 CA CYS E 96 50. ,874 -50, .504 -55. .974 1. 00 28. 02 E c

ATOM 17999 CB CYS E 96 51. ,855 -51. .607 -56. ,411 1. 00 28. 06 E c

ATOM 18002 SG CYS E 96 51.699 -53. .139 -55. ,512 1. 00 32. 92 E S

ATOM 18004 C CYS E 96 49. ,426 -50. .860 -56. ,286 1. 00 23. 39 E c

ATOM 18005 0 CYS E 96 48. ,676 -51. .360 -55. ,434 1. 00 22. 74 E 0

ATOM 18007 N GLU E 97 49. ,032 -50. .549 -57. ,507 1. 00 21. 55 E N

ATOM 18008 CA GLU E 97 47. ,721 -50. .839 -57. 985 1. 00 20. 52 E c

ATOM 18010 CB GLU E 97 46. ,837 -49. .587 -57. ,876 1. 00 26. 41 E c

ATOM 18013 CG GLU E 97 45. 426 -49. ,752 -58. ,465 1. 00 24. 17 E c

ATOM 18016 CD GLU E 97 44. 740 -48. ,442 -58. ,791 1. 00 25. 51 E c

ATOM 18017 OEl GLU E 97 45. 445 -47. ,468 -59. ,116 1. 00 27. 02 E 0

ATOM 18018 OE2 GLU E 97 43. ,488 -48, .409 -58. ,745 1. 00 23. 30 E 0

ATOM 18019 C GLU E 97 47. ,840 -51. .255 -59. ,436 1. 00 23. 91 E c

ATOM 18020 0 GLU E 97 48. ,330 -50. .507 -60. ,263 1. 00 22. 36 E 0

ATOM 18022 N ARG E 98 47. 366 -52, .440 -59. ,765 1. 00 26. 29 E N

ATOM 18023 CA ARG E 98 47. 316 -52. ,814 -61. ,159 1. 00 24. 99 E c

ATOM 18025 CB ARG E 98 46. ,925 -54. ,276 -61.286 1. 00 26. 18 E c

ATOM 18028 CG ARG E 98 46. 875 -54. .759 -62. ,702 1. 00 27. 37 E c

ATOM 18031 CD ARG E 98 46. 392 -56. ,159 -62. ,757 1. 00 24. 02 E c

ATOM 18034 NE ARG E 98 44. 947 -56. ,254 -62. ,627 1. 00 20. 20 E N

ATOM 18036 CZ ARG E 98 44. 232 -57. ,291 -63. ,027 1. 00 20. 72 E c

ATOM 18037 NHl ARG E 98 44. 828 -58. ,334 -63. ,584 1. 00 20. 91 E N

ATOM 18040 NH2 ARG E 98 42. 906 -57. .278 -62. ,895 1. 00 19. 62 E N

ATOM 18043 C ARG E 98 46. 337 -51, ,882 -61. .884 1. 00 23. 45 E C

ATOM 18044 0 ARG E 98 45. ,215 -51, .678 -61. .423 1. 00 23. 36 E 0

ATOM 18046 N GLU E 99 46. ,781 -51, .294 -62. .997 1. 00 23. 02 E N

ATOM 18047 CA GLU E 99 45. ,910 -50. .493 -63. ,893 1. 00 27. 53 E C

ATOM 18049 CB GLU E 99 46. ,764 -49. .405 -64. ,551 1. 00 24. 81 E C

ATOM 18052 CG GLU E 99 46. 009 -48, ,497 -65. ,500 1. 00 19. 47 E c

ATOM 18055 CD GLU E 99 44. 822 -47. .843 -64. ,880 1. 00 25. 79 E c

ATOM 18056 OEl GLU E 99 44. 718 -47. .780 -63. ,630 1. 00 23. 21 E 0

ATOM 18057 OE2 GLU E 99 43. ,984 -47. .361 -65. ,662 1. 00 27. 51 E 0

ATOM 18058 C GLU E 99 45. ,414 -51, .465 -64. ,942 1. 00 26. 47 E c

ATOM 18059 0 GLU E 99 46. 049 -51. .609 -65. ,978 1. 00 30. 84 E 0

ATOM 18061 N GLY E 100 44. ,299 -52, .152 -64. .748 1. 00 33. 02 E N

ATOM 18062 CA GLY E 100 42. ,912 -51, .710 -64. ,957 1. 00 27. 89 E c

ATOM 18065 C GLY E 100 42. ,283 -53, .123 -64. ,875 1. 00 28. 71 E c

ATOM 18066 0 GLY E 100 42. ,874 -54, ,001 -64. ,248 1. 00 29. 43 E 0

ATOM 18068 N GLY E 101 41. ,128 -53, .387 -65, ,487 1. 00 33. 38 E N

ATOM 18069 CA GLY E 101 40. ,415 -54, .653 -65. .258 1. 00 29. 46 E c

ATOM 18072 C GLY E 101 39. ,858 -54, .667 -63, ,845 1. 00 27. 19 E c

ATOM 18073 0 GLY E 101 39. ,791 -53, .633 -63. ,190 1. 00 29. 35 E 0

ATOM 18075 N VAL E 108 39. ,471 -55, .833 -63. ,351 1. 00 29. 50 E N

ATOM 18076 CA VAL E 108 38. ,991 -55, .936 -61, ,968 1. 00 26. 08 E c

ATOM 18078 CB VAL E 108 38. ,706 -57, .397 -61, .556 1. 00 22. 76 E c

ATOM 18080 CGl VAL E 108 38. ,468 -57, .500 -60, .035 1. 00 12. 62 E c

ATOM 18084 CG2 VAL E 108 37. ,514 -57, .924 -62, .351 1. 00 23. ,11 E c

ATOM 18088 C VAL E 108 40. ,059 -55, .323 -61, .083 1. 00 23. 76 E c

ATOM 18089 0 VAL E 108 41. ,213 -55, .740 -61, .127 1. 00 29. ,15 E 0

ATOM 18091 N ASN E 109 39. ,677 -54, .325 -60, .297 1. 00 25. ,50 E N

ATOM 18092 CA ASN E 109 40. ,641 -53, .463 -59. .613 1. 00 26. 20 E c

ATOM 18094 CB ASN E 109 39. ,958 -52, .186 -59, ,141 1. 00 24. ,73 E c cyno fD_Fab

ATOM 18097 CG ASN E 109 40. 947 -51. 134 -58. ,688 1.00 24. 12 E C

ATOM 18098 ODl ASN E 109 41. ,635 -50. 531 -59. ,495 1.00 29. 11 E 0

ATOM 18099 ND2 ASN E 109 40. 992 -50. 888 -57. ,398 1.00 20. 31 E N

ATOM 18102 C ASN E 109 41. 350 -54. 111 -58. ,421 1.00 28. 69 E C

ATOM 18103 O ASN E 109 40. ,724 -54. 396 -57. ,405 1.00 22. 78 E 0

ATOM 18105 N ASN E 110 42. ,672 -54. 264 -58. ,556 1.00 26. 87 E N

ATOM 18106 CA ASN E 110 43. 522 -54. 890 -57. ,557 1.00 27. 53 E C

ATOM 18108 CB ASN E 110 44. 113 -56. 164 -58. ,140 1.00 27. 19 E c

ATOM 18111 CG ASN E 110 43. 118 -57. 300 -58. ,137 1.00 28. 62 E c

ATOM 18112 ODl ASN E 110 42. 999 -58. 018 -57. ,146 1.00 33. 65 E 0

ATOM 18113 ND2 ASN E 110 42. 387 -57. 460 -59. ,233 1.00 22. 75 E N

ATOM 18116 C ASN E 110 44. 643 -53. 994 -57. ,014 1.00 28. 89 E c

ATOM 18117 O ASN E 110 45. 389 -53. 381 -57. ,784 1.00 26. 09 E 0

ATOM 18119 N TRP E 111 44. 731 -53. 932 -55. ,678 1.00 25. 29 E N

ATOM 18120 CA TRP E 111 45. ,787 -53. 214 -54. ,975 1.00 25. 75 E c

ATOM 18122 CB TRP E 111 45. 196 -52. 264 -53. ,961 1.00 21. 23 E c

ATOM 18125 CG TRP E 111 44. ,494 -51. 114 -54. 532 1.00 21.11 E c

ATOM 18126 CDl TRP E 111 43. 388 -51. 141 -55. 315 1.00 19. 91 E c

ATOM 18128 NEl TRP E 111 43. 010 -49. 872 -55. 632 1.00 22. 06 E N

ATOM 18130 CE2 TRP E 111 43. 876 -48. 988 -55. 055 1.00 20. 26 E c

ATOM 18131 CD2 TRP E 111 44. 822 -49. 740 -54. 345 1.00 18. 19 E c

ATOM 18132 CE3 TRP E 111 45. 835 -49. 072 -53. ,662 1.00 22. 18 E c

ATOM 18134 CZ3 TRP E 111 45. 875 -47. 694 -53. ,722 1.00 21.63 E c

ATOM 18136 CH2 TRP E 111 44. 901 -46. 973 -54. ,417 1.00 22. 86 E c

ATOM 18138 CZ2 TRP E 111 43. 901 -47. 600 -55. ,097 1.00 19. 37 E c

ATOM 18140 C TRP E 111 46. 669 -54. 192 -54. 203 1.00 27. 25 E c

ATOM 18141 O TRP E 111 46. 196 -55. 256 -53. ,786 1.00 27. 81 E 0

ATOM 18143 N GLY E 112 47. 935 -53. 815 -54. ,000 1.00 26. 66 E N

ATOM 18144 CA GLY E 112 48. 783 -54. 448 -52. 996 1.00 27. 29 E c

ATOM 18147 C GLY E 112 48. 365 -54. 001 -51. ,601 1.00 25. 61 E c

ATOM 18148 O GLY E 112 47. 526 -53. 121 -51. ,458 1.00 32. 03 E 0

ATOM 18150 N GLN E 113 48. 950 -54. 607 -50. ,573 1.00 31. 54 E N

ATOM 18151 CA GLN E 113 48. 557 -54. 337 -49. ,180 1.00 26. 71 E c

ATOM 18153 CB GLN E 113 48. 842 -55. 565 -48. ,285 1.00 29. 26 E c

ATOM 18156 CG GLN E 113 50. 296 -55. 744 -47. ,734 1.00 31. 08 E c

ATOM 18159 CD GLN E 113 51. 279 -56. 362 -48. ,732 1.00 31.05 E c

ATOM 18160 OEl GLN E 113 51. 025 -56. 398 -49. ,938 1.00 28. 43 E 0

ATOM 18161 NE2 GLN E 113 52. 417 -56. 855 -48. 222 1.00 29. 99 E N

ATOM 18164 C GLN E 113 49. 182 -53. 066 -48. ,600 1.00 27. 85 E c

ATOM 18165 0 GLN E 113 48. 803 -52. 619 -47. ,510 1.00 28. 73 E 0

ATOM 18167 N GLY E 114 50. 117 -52. 468 -49. ,336 1.00 29. 66 E N

ATOM 18168 CA GLY E 114 50. 833 -51. 287 -48. ,869 1.00 27. 88 E C

ATOM 18171 C GLY E 114 52. 127 -51. 660 -48. ,170 1.00 26. 39 E C

ATOM 18172 0 GLY E 114 52. ,207 -52. 684 -47. ,506 1.00 26. 61 E 0

ATOM 18174 N THR E 115 53. 146 -50. 831 -48. ,368 1.00 25. 61 E N

ATOM 18175 CA THR E 115 54. 359 -50. 864 -47. ,578 1.00 24. 35 E c

ATOM 18177 CB THR E 115 55. 629 -50. 996 -48. ,452 1.00 19. ,13 E c

ATOM 18179 OGl THR E 115 55. 542 -52. 158 -49. ,286 1.00 17. 95 E 0

ATOM 18181 CG2 THR E 115 56. 848 -51. 089 -47. ,557 1.00 22. ,18 E c

ATOM 18185 C THR E 115 54. 480 -49. 555 -46. ,811 1.00 22. ,42 E c

ATOM 18186 0 THR E 115 54. 521 -48. 496 -47. ,411 1.00 25. 63 E 0

ATOM 18188 N LEU E 116 54. 571 -49. 628 -45. ,485 1.00 25. 47 E N

ATOM 18189 CA LEU E 116 54. ,910 -48. 449 -44. ,701 1.00 23. ,68 E c

ATOM 18191 CB LEU E 116 54. ,309 -48. 561 -43. ,307 1.00 25. ,55 E c

ATOM 18194 CG LEU E 116 54. 512 -47. 397 -42. ,329 1.00 26. ,87 E c

ATOM 18196 CDl LEU E 116 54. ,370 -46. 052 -43. ,006 1.00 28. ,24 E c

ATOM 18200 CD 2 LEU E 116 53. ,515 -47. 520 -41, ,201 1.00 29. ,87 E c

ATOM 18204 C LEU E 116 56. ,438 -48. 270 -44. ,638 1.00 24. ,44 E c

ATOM 18205 0 LEU E 116 57. ,146 -49. 167 -44. ,204 1.00 20. ,30 E 0

ATOM 18207 N VAL E 117 56. 933 -47. 123 -45. ,113 1.00 25. ,27 E N

ATOM 18208 CA VAL E 117 58. 341 -46. 739 -44. ,984 1.00 20. ,16 E c

ATOM 18210 CB VAL E 117 58. 890 -46. 197 -46. ,299 1.00 23. ,11 E c

ATOM 18212 CGI VAL E 117 60. ,348 -45. ,724 -46, ,140 1.00 19. ,22 E c

ATOM 18216 CG2 VAL E 117 58. ,761 -47. ,248 -47. ,394 1.00 25. ,16 E c

ATOM 18220 C VAL E 117 58. ,396 -45. 622 -43. ,946 1.00 20. ,45 E c

ATOM 18221 0 VAL E 117 57. ,644 -44. 677 -44. ,039 1.00 20. ,27 E 0

ATOM 18223 N THR E 118 59. ,244 -45. 768 -42. ,933 1.00 21. ,82 E N

ATOM 18224 CA THR E 118 59. ,450 -44. 740 -41. ,907 1.00 21.54 E c cyno fD_Fab

ATOM 18226 CB THR E 118 59. ,273 -45. ,336 -40. 488 1. 00 21. ,53 E C

ATOM 18228 OGl THR E 118 57. ,911 -45. ,748 -40. 313 1. 00 25. ,56 E 0

ATOM 18230 CG2 THR E 118 59. 644 -44. ,330 -39. 399 1. 00 19. 60 E C

ATOM 18234 C THR E 118 60. 865 -44. ,211 -42. 085 1. 00 21. 66 E C

ATOM 18235 O THR E 118 61. 800 -45. ,000 -42. 178 1. 00 22. 62 E 0

ATOM 18237 N VAL E 119 61. 024 -42. ,894 -42. 178 1. 00 20. 55 E N

ATOM 18238 CA VAL E 119 62. ,357 -42. ,302 -42. 253 1. 00 23. ,29 E C

ATOM 18240 CB VAL E 119 62. ,494 -41. ,312 -43. 411 1. 00 19. ,13 E c

ATOM 18242 CGl VAL E 119 63. 930 -40. ,865 -43. 510 1. 00 17. 35 E c

ATOM 18246 CG2 VAL E 119 62. 025 -41. ,956 -44. 737 1. 00 18. 28 E c

ATOM 18250 C VAL E 119 62. 713 -41. ,606 -40. 931 1. 00 27. 58 E c

ATOM 18251 O VAL E 119 62. 202 -40. ,531 -40. 633 1. 00 29. 65 E 0

ATOM 18253 N SER E 120 63. 599 -42. 233 -40. 158 1. 00 29. 33 E N

ATOM 18254 CA SER E 120 63. 987 -41. 753 -38. 830 1. 00 33. ,19 E c

ATOM 18256 CB SER E 120 63. 115 -42. 410 -37. 756 1. 00 35. 20 E c

ATOM 18259 OG SER E 120 63. ,167 -41.676 -36. 541 1. 00 36. 92 E 0

ATOM 18261 C SER E 120 65. 442 -42. ,092 -38. 543 1. 00 32. ,72 E c

ATOM 18262 O SER E 120 65. 990 -43. ,009 -39. 141 1. 00 30. ,45 E 0

ATOM 18264 N SER E 121 66. 060 -41. ,355 -37. 623 1. 00 37. ,17 E N

ATOM 18265 CA SER E 121 67. 389 -41. 723 -37. 103 1. 00 37. 20 E C

ATOM 18267 CB SER E 121 68. 151 -40. 488 -36. 608 1. 00 37. 78 E C

ATOM 18270 OG SER E 121 68. 500 -39. 621 -37. 679 1. 00 34. 29 E 0

ATOM 18272 C SER E 121 67. 260 -42. 750 -35. 971 1. 00 40. 95 E C

ATOM 18273 O SER E 121 68. 225 -43. 446 -35. 639 1. 00 41. 76 E 0

ATOM 18275 N ALA E 122 66. 061 -42. ,842 -35. 391 1. 00 40. ,67 E N

ATOM 18276 CA ALA E 122 65. 785 -43. ,767 -34. 291 1. 00 38. ,63 E C

ATOM 18278 CB ALA E 122 64. 397 -43. 480 -33. 694 1. 00 35. ,96 E C

ATOM 18282 C ALA E 122 65. 885 -45. 223 -34. 742 1. 00 38. 47 E c

ATOM 18283 O ALA E 122 65. 773 -45. 529 -35. 935 1. 00 38. 78 E 0

ATOM 18285 N SER E 123 66. 097 -46. ,115 -33. 777 1. 00 39. 35 E N

ATOM 18286 CA SER E 123 66. 339 -47. ,528 -34. 054 1. 00 39. 23 E c

ATOM 18288 CB SER E 123 67. 551 -48. 032 -33. 260 1. 00 43. 17 E c

ATOM 18291 OG SER E 123 68. 700 -47. 227 -33. 502 1. 00 44. 30 E 0

ATOM 18293 C SER E 123 65. 103 -48. ,345 -33. 713 1. 00 39. ,02 E c

ATOM 18294 O SER E 123 64. 218 -47. ,876 -33. 001 1. 00 40. ,07 E 0

ATOM 18296 N THR E 124 65. 052 -49. ,567 -34. 231 1. 00 40. ,54 E N

ATOM 18297 CA THR E 124 63. 891 -50. ,432 -34. 082 1. 00 39. ,95 E c

ATOM 18299 CB THR E 124 63. 958 -51. ,621 -35. 057 1. 00 40. ,85 E c

ATOM 18301 OGl THR E 124 63. 953 -51. ,134 -36. 406 1. 00 42. ,41 E 0

ATOM 18303 CG2 THR E 124 62. 770 -52. ,552 -34. 857 1. 00 42. ,33 E c

ATOM 18307 C THR E 124 63. 780 -50. ,963 -32. 656 1. 00 42. 60 E c

ATOM 18308 O THR E 124 64. 792 -51. ,239 -32. 010 1. 00 44. 92 E 0

ATOM 18310 N LYS E 125 62. 548 -51. ,081 -32. 169 1. 00 40. ,05 E N

ATOM 18311 CA LYS E 125 62. 281 -51. ,685 -30. ,872 1. 00 38. 98 E C

ATOM 18313 CB LYS E 125 62. 200 -50.625 -29. ,773 1. 00 39. 76 E C

ATOM 18316 CG LYS E 125 62. 200 -51. 233 -28. ,373 1. 00 41. 99 E c

ATOM 18319 CD LYS E 125 61. 798 -50. ,236 -27. ,295 1. 00 42. 24 E c

ATOM 18322 CE LYS E 125 61. 602 -50. ,919 -25. 932 1. 00 42. 89 E c

ATOM 18325 NZ LYS E 125 60. 554 -52. ,004 -25. ,930 1. 00 41. 30 E N

ATOM 18329 C LYS E 125 60. 982 -52. ,463 -30. 915 1. 00 35. 23 E c

ATOM 18330 0 LYS E 125 59. 942 -51. ,917 -31. 267 1. 00 36. ,71 E 0

ATOM 18332 N GLY E 126 61. ,041 -53. ,734 -30. ,549 1. 00 35. ,30 E N

ATOM 18333 CA GLY E 126 59. 846 -54. ,559 -30. ,451 1. 00 35. .86 E c

ATOM 18336 C GLY E 126 59. 013 -54. ,184 -29. ,241 1. 00 36. ,40 E c

ATOM 18337 O GLY E 126 59. 536 -53. .660 -28. ,252 1. 00 37. ,85 E 0

ATOM 18339 N PRO E 127 57. 708 -54. ,463 -29. ,297 1. 00 35. 89 E N

ATOM 18340 CA PRO E 127 56. 833 -54. ,111 -28. ,190 1. 00 35. ,78 E c

ATOM 18342 CB PRO E 127 55. 443 -54. ,197 -28. 822 1. 00 36. ,64 E c

ATOM 18345 CG PRO E 127 55. 578 -55. ,259 -29. ,849 1. 00 36. ,16 E c

ATOM 18348 CD PRO E 127 56. 978 -55. ,136 -30. ,385 1. 00 35. ,95 E c

ATOM 18351 C PRO E 127 56. ,921 -55. ,076 -27. ,009 1. 00 36. .88 E c

ATOM 18352 O PRO E 127 57. 202 -56. ,264 -27. ,191 1. 00 39. ,55 E 0

ATOM 18353 N SER E 128 56. 696 -54. ,557 -25. ,807 1. 00 33. .11 E N

ATOM 18354 CA SER E 128 56. ,311 -55. ,391 -24. ,679 1. 00 32. .71 E c

ATOM 18356 CB SER E 128 56. ,673 -54. ,730 -23. ,345 1. 00 35. ,31 E c

ATOM 18359 OG SER E 128 58. 071 -54. ,527 -23. 222 1. 00 34. ,75 E 0

ATOM 18361 C SER E 128 54. 803 -55. ,538 -24. 788 1. 00 31. ,04 E c

ATOM 18362 O SER E 128 54. 120 -54. ,594 -25. ,172 1. 00 31. ,18 E 0 cyno fD_Fab

ATOM 18364 N VAL E 129 54. ,273 -56. 710 -24. 467 1.00 29. 61 E N

ATOM 18365 CA VAL E 129 52. ,823 -56. 915 -24. 505 1.00 30. ,55 E C

ATOM 18367 CB VAL E 129 52. ,429 -57. 962 -25. 557 1.00 28. ,60 E C

ATOM 18369 CGI VAL E 129 50. ,928 -57. 942 -25. 789 1.00 29. ,67 E C

ATOM 18373 CG2 VAL E 129 53. ,177 -57. 702 -26. 868 1.00 29. ,87 E C

ATOM 18377 C VAL E 129 52. ,315 -57. 326 -23. ,116 1.00 31. ,56 E C

ATOM 18378 O VAL E 129 52. ,738 -58. ,346 -22. ,572 1.00 35. ,46 E 0

ATOM 18380 N PHE E 130 51. ,424 -56. ,518 -22. 547 1.00 28. ,21 E N

ATOM 18381 CA PHE E 130 50. ,883 -56. ,761 -21. ,214 1.00 27. 39 E C

ATOM 18383 CB PHE E 130 51. ,134 -55. 557 -20. 308 1.00 27. ,09 E C

ATOM 18386 CG PHE E 130 52. 575 -55. 133 -20. 246 1.00 27. ,89 E c

ATOM 18387 CDl PHE E 130 53. ,548 -56. 003 -19. 779 1.00 27. ,27 E c

ATOM 18389 CEl PHE E 130 54. ,876 -55. 618 -19. 716 1.00 26. 86 E c

ATOM 18391 CZ PHE E 130 55. ,248 -54. 354 -20. 118 1.00 26. ,67 E c

ATOM 18393 CE2 PHE E 130 54. ,290 -53. ,472 -20. ,577 1.00 27. ,39 E c

ATOM 18395 CD2 PHE E 130 52. ,958 -53. ,862 -20. 637 1.00 27. ,47 E c

ATOM 18397 C PHE E 130 49. ,390 -57. ,018 -21.305 1.00 26. ,91 E c

ATOM 18398 O PHE E 130 48. ,736 -56. 517 -22. ,212 1.00 29. ,62 E 0

ATOM 18400 N PRO E 131 48. 833 -57. ,781 -20.353 1.00 27. ,51 E N

ATOM 18401 CA PRO E 131 47. 410 -58. 058 -20. 395 1.00 28. ,15 E c

ATOM 18403 CB PRO E 131 47. ,313 -59. 408 -19. 695 1.00 27. ,96 E c

ATOM 18406 CG PRO E 131 48. ,407 -59. 372 -18. 680 1.00 27. 60 E c

ATOM 18409 CD PRO E 131 49. ,475 -58. 444 -19. 204 1.00 28. ,14 E c

ATOM 18412 C PRO E 131 46. ,590 -57. 017 -19. 646 1.00 30. 60 E c

ATOM 18413 O PRO E 131 47. ,012 -56. ,532 -18. ,593 1.00 37. ,40 E 0

ATOM 18414 N LEU E 132 45. ,426 -56. 688 -20. ,196 1.00 28. ,76 E N

ATOM 18415 CA LEU E 132 44. 453 -55. ,857 -19. ,514 1.00 28. ,34 E c

ATOM 18417 CB LEU E 132 43. 860 -54. 824 -20. ,477 1.00 27. ,41 E c

ATOM 18420 CG LEU E 132 44. ,899 -53. 922 -21. ,143 1.00 26. ,15 E c

ATOM 18422 CDl LEU E 132 44. ,283 -53. 076 -22. 245 1.00 26. ,83 E c

ATOM 18426 CD2 LEU E 132 45. ,553 -53. 042 -20. 103 1.00 29. ,76 E c

ATOM 18430 C LEU E 132 43. ,405 -56. 819 -18. 995 1.00 27. 96 E c

ATOM 18431 0 LEU E 132 42. 488 -57. 192 -19. 721 1.00 31. 86 E 0

ATOM 18433 N ALA E 133 43. ,573 -57. 243 -17. ,740 1.00 32. ,75 E N

ATOM 18434 CA ALA E 133 42. ,770 -58. 314 -17. ,164 1.00 30. ,19 E c

ATOM 18436 CB ALA E 133 43. ,406 -58. 801 -15. ,864 1.00 32. ,23 E c

ATOM 18440 C ALA E 133 41. ,328 -57. 865 -16. 917 1.00 30. ,06 E c

ATOM 18441 0 ALA E 133 41. ,103 -56. 747 -16. ,455 1.00 32. ,27 E 0

ATOM 18443 N PRO E 134 40. ,344 -58. 732 -17. 226 1.00 30. ,05 E N

ATOM 18444 CA PRO E 134 38. ,950 -58. 433 -16. 880 1.00 34. ,10 E c

ATOM 18446 CB PRO E 134 38. ,169 -59. 491 -17. ,650 1.00 31. ,15 E c

ATOM 18449 CG PRO E 134 39. ,106 -60. 632 -17. 774 1.00 30. ,14 E c

ATOM 18452 CD PRO E 134 40. ,476 -60. 040 -17. 893 1.00 28. ,56 E c

ATOM 18455 C PRO E 134 38. ,723 -58. ,576 -15. ,374 1.00 39. ,66 E c

ATOM 18456 0 PRO E 134 39. ,459 -59. ,325 -14. ,728 1.00 44. ,60 E 0

ATOM 18457 N SER E 135 37. ,730 -57. ,879 -14. ,814 1.00 43. ,36 E N

ATOM 18458 CA SER E 135 37. ,579 -57. ,821 -13. ,344 1.00 44. ,93 E c

ATOM 18460 CB SER E 135 38. ,511 -56. ,744 -12. ,774 1.00 47. .21 E c

ATOM 18463 OG SER E 135 38. ,208 -55. ,468 -13. ,315 1.00 46. .19 E 0

ATOM 18465 C SER E 135 36. ,146 -57. ,587 -12. ,842 1.00 47. .31 E c

ATOM 18466 0 SER E 135 35. ,227 -57. ,366 -13. ,634 1.00 44. .36 E 0

ATOM 18468 N SER E 136 35. ,984 -57. ,641 -11. ,513 1.00 48. .97 E N

ATOM 18469 CA SER E 136 34. ,674 -57. ,548 -10. ,846 1.00 47. .51 E c

ATOM 18471 CB SER E 136 34. ,852 -57. ,581 -9. ,323 1.00 48. ,26 E c

ATOM 18474 OG SER E 136 35. ,563 -58. ,738 -8. ,916 1.00 46. ,55 E 0

ATOM 18476 C SER E 136 33. ,883 -56. ,305 -11. ,233 1.00 47. ,90 E c

ATOM 18477 0 SER E 136 32. ,987 -56. ,370 -12. ,077 1.00 49. ,31 E 0

ATOM 18479 N GLY E 142 26. ,205 -60. ,189 -17. ,298 1.00 47. .53 E N

ATOM 18480 CA GLY E 142 26, ,622 -58. ,914 -17. ,882 1.00 48. ,55 E c

ATOM 18483 C GLY E 142 27. ,757 -59. ,026 -18. ,896 1.00 50. .08 E c

ATOM 18484 0 GLY E 142 28. ,189 -60. ,131 -19. ,236 1.00 51. .62 E 0

ATOM 18486 N THR E 143 28. ,235 -57. ,875 -19. ,378 1.00 48, ,52 E N

ATOM 18487 CA THR E 143 29. ,347 -57. ,809 -20. ,337 1.00 45. .44 E c

ATOM 18489 CB THR E 143 29. ,082 -56. ,749 -21.413 1.00 46, ,39 E c

ATOM 18491 OGl THR E 143 27. ,891 -57. ,099 -22. ,124 1.00 48, ,21 E 0

ATOM 18493 CG2 THR E 143 30. ,242 -56. ,651 -22. ,399 1.00 45. .23 E c

ATOM 18497 C THR E 143 30. ,665 -57. ,490 -19. ,633 1.00 44. .27 E c

ATOM 18498 0 THR E 143 30, ,701 -56. ,701 -18. ,684 1.00 43. .94 E 0 cyno fD_Fab

ATOM 18500 N ALA E 144 31. ,739 -58. 122 -20. ,104 1. 00 40, ,61 E N

ATOM 18501 CA ALA E 144 33. ,076 -57. 922 -19. ,563 1. 00 38. ,56 E C

ATOM 18503 CB ALA E 144 33. ,610 -59. 219 -18. ,992 1. 00 42. ,64 E C

ATOM 18507 C ALA E 144 34. ,010 -57. 388 -20. ,648 1. 00 37. ,69 E c

ATOM 18508 O ALA E 144 33. ,764 -57. 573 -21. ,851 1. 00 33. ,81 E 0

ATO 18510 N ALA E 145 35. ,068 -56. 708 -20. ,206 1. 00 36. ,38 E N

ATOM 18511 CA ALA E 145 36. ,053 -56. 099 -21. ,095 1. 00 33. ,12 E c

ATOM 18513 CB ALA E 145 35. 943 -54. 574 -21.054 1. 00 34. ,74 E c

ATOM 18517 C ALA E 145 37. 455 -56. 532 -20. ,714 1. 00 29. ,43 E c

ATOM 18518 O ALA E 145 37. ,796 -56. 599 -19. ,532 1. 00 29. ,62 E 0

ATOM 18520 N LEU E 146 38. ,255 -56. 844 -21. ,727 1. 00 27. 86 E N

ATOM 18521 CA LEU E 146 39. ,657 -57. 206 -21. ,549 1. 00 29. ,49 E c

ATOM 18523 CB LEU E 146 39. ,821 -58. 719 -21, ,341 1. 00 29. ,77 E c

ATOM 18526 CG LEU E 146 39. ,246 -59. 633 -22. ,433 1. 00 26. ,61 E c

ATOM 18528 CDl LEU E 146 40. ,267 -60. 675 -22. ,847 1. 00 26. ,32 E c

ATOM 18532 CD2 LEU E 146 37. 926 -60. 280 -21. ,996 1. 00 23. ,96 E c

ATOM 18536 C LEU E 146 40. 450 -56. 764 -22. ,770 1. 00 31. ,49 E c

ATOM 18537 O LEU E 146 39. 880 -56. 336 -23. ,777 1. 00 35. ,03 E 0

ATOM 18539 N GLY E 147 41. 766 -56. 865 -22. ,675 1. 00 32. 33 E N

ATOM 18540 CA GLY E 147 42. 617 -56. 430 -23. ,756 1. 00 29. ,40 E c

ATOM 18543 C GLY E 147 44. 084 -56. 714 -23. ,534 1. 00 30. ,48 E c

ATOM 18544 O GLY E 147 44. ,463 -57. 451 -22. ,617 1. 00 27. ,50 E 0

ATOM 18546 N CYS E 148 44. ,899 -56. 115 -24, ,397 1. 00 32. ,26 E N

ATOM 18547 CA CYS E 148 46. ,347 -56. 199 -24. ,322 1. 00 30. ,95 E c

ATOM 18549 CB CYS E 148 46. 886 -57. 160 -25. ,384 1. 00 35. ,56 E c

ATOM 18552 SG CYS E 148 46. 523 -58. 919 -25. ,111 1. 00 35. ,80 E s

ATOM 18554 C CYS E 148 46. 910 -54. 813 -24. ,571 1. 00 28. ,43 E c

ATOM 18555 O CYS E 148 46. 382 -54. 074 -25. ,397 1. 00 30. ,92 E 0

ATOM 18557 N LEU E 149 47. 976 -54. 468 -23. 855 1. 00 27. ,83 E N

ATOM 18558 CA LEU E 149 48. 656 -53. 182 -24. 015 1. 00 26. ,51 E c

ATOM 18560 CB LEU E 149 48. 942 -52. 565 -22. 639 1. 00 24. ,18 E c

ATOM 18563 CG LEU E 149 49. 843 -51. 325 -22. 563 1. 00 25. ,00 E c

ATOM 18565 CDl LEU E 149 49. 278 -50. 182 -23. ,426 1. 00 21.79 E c

ATOM 18569 CD2 LEU E 149 50. 042 -50. 871 -21.125 1. 00 19. ,16 E c

ATOM 18573 C LEU E 149 49. ,951 -53. 425 -24. ,775 1. 00 27. ,61 E c

ATOM 18574 O LEU E 149 50. 853 -54. 066 -24, ,257 1. 00 28. ,51 E 0

ATOM 18576 N VAL E 150 50. 031 -52. 944 -26. ,011 1. 00 31. ,28 E N

ATOM 18577 CA VAL E 150 51. 232 -53. 126 -26, ,833 1. 00 29. ,61 E c

ATOM 18579 CB VAL E 150 50. 866 -53. 370 -28. .312 1. 00 27. ,28 E c

ATOM 18581 CGI VAL E 150 52. 108 -53. 456 -29. ,188 1. 00 24. ,24 E c

ATOM 18585 CG2 VAL E 150 50. 042 -54. 664 -28. ,438 1. 00 26. ,74 E c

ATOM 18589 C VAL E 150 52. 087 -51. 880 -26. ,626 1. 00 30. 58 E c

ATOM 18590 O VAL E 150 51. 768 -50. 812 -27. ,128 1. 00 32. ,39 E 0

ATOM 18592 N LYS E 151 53. 162 -52. 031 -25. ,860 1. 00 32. ,82 E N

ATOM 18593 CA LYS E 151 53. 856 -50. 898 -25. ,249 1. 00 32. ,40 E c

ATOM 18595 CB LYS E 151 53. 885 -51. 118 -23. ,734 1. 00 35. ,97 E c

ATOM 18598 CG LYS E 151 54. ,494 -49. 990 -22. ,896 1. 00 36. ,11 E c

ATOM 18601 CD LYS E 151 53. ,509 -48. 884 -22. ,584 1. 00 36. ,41 E c

ATOM 18604 CE LYS E 151 53. 936 -48. 105 -21. .348 1. 00 36. ,60 E c

ATOM 18607 NZ LYS E 151 55. 399 -47. 866 -21. ,311 1. 00 36. ,68 E N

ATOM 18611 C LYS E 151 55. 280 -50. 724 -25. ,782 1. 00 30. ,30 E c

ATOM 18612 0 LYS E 151 56. 005 -51. 694 -25. ,959 1. 00 32. ,16 E 0

ATOM 18614 N ASP E 152 55. 664 -49. 475 -26. ,033 1. 00 31. ,04 E N

ATOM 18615 CA ASP E 152 57. 053 -49. 099 -26. ,325 1. 00 32. ,69 E c

ATOM 18617 CB ASP E 152 57. 945 -49. 356 -25. ,104 1. 00 36. ,61 E c

ATOM 18620 CG ASP E 152 57. 620 -48. 447 -23. ,931 1. 00 37. ,42 E c

ATOM 18621 ODl ASP E 152 57. 283 -47. 262 -24. ,152 1. 00 37. ,77 E 0

ATOM 18622 OD2 ASP E 152 57. ,730 -48. 924 -22, ,782 1. 00 36. .80 E 0

ATOM 18623 C ASP E 152 57. ,655 -49. 786 -27, .551 1. 00 32. ,28 E c

ATOM 18624 0 ASP E 152 58. ,522 -50. 652 -27, .425 1. 00 31. .31 E 0

ATOM 18626 N TYR E 153 57. ,201 -49. 384 -28, ,736 1. 00 33. ,88 E N

ATOM 18627 CA TYR E 153 57. ,767 -49. 893 -29. .990 1. 00 30. ,40 E c

ATOM 18629 CB TYR E 153 56. 849 -50. 933 -30. .619 1. 00 26. ,56 E c

ATOM 18632 CG TYR E 153 55. 517 -50. 416 -31. ,113 1. 00 28. ,23 E c

ATOM 18633 CDl TYR E 153 55. 355 -49. 984 -32. ,438 1. 00 24. ,58 E c

ATOM 18635 CEl TYR E 153 54. 134 -49. 541 -32. .897 1. 00 25. ,36 E c

ATOM 18637 CZ TYR E 153 53. 055 -49. 515 -32. ,028 1. 00 25. ,71 E c

ATOM 18638 OH TYR E 153 51.846 -49. 076 -32, ,460 1. 00 26. ,75 E 0 fD_Fab

ATOM 18640 CE2 TYR E 153 53. .3? -49. 940 -30. ,713 1.00 25. 56 E C

ATOM 18642 CD2 TYR E 153 54, .407 -50. 392 -30. ,271 1.00 23. 50 E C

ATOM 18644 C TYR E 153 58, .072 -48. 799 -31. ,002 1.00 28. ,97 E c

ATOM 18645 O TYR E 153 57. .570 -47. 683 -30. ,900 1.00 29. 19 E 0

ATOM 18647 N PHE E 154 58. .922 -49. 145 -31. 963 1.00 31. ,25 E N

ATOM 18648 CA PHE E 154 59. ,287 -48. 267 -33. ,059 1.00 31. ,43 E c

ATOM 18650 CB PHE E 154 60. ,357 -47. 266 -32. ,633 1.00 34. ,03 E c

ATOM 18653 CG PHE E 154 60. ,538 -46. 139 -33. ,608 1.00 34. ,05 E c

ATOM 18654 CDl PHE E 154 59, .711 -45. 021 -33. ,556 1.00 35. ,89 E c

ATOM 18656 CEl PHE E 154 59, .865 -43. 973 -34.464 1.00 35. ,55 E c

ATOM 18658 CZ PHE E 154 60, ,848 -44. 043 -35. 444 1.00 34. ,82 E c

ATOM 18660 CE2 PHE E 154 61. .675 -45. 154 -35. 514 1.00 34. ,11 E c

ATOM 18662 CD2 PHE E 154 61. .517 -46. 200 -34. 597 1.00 35. ,48 E c

ATOM 18664 C PHE E 154 59. .828 -49. 127 -34. 194 1.00 32. ,38 E c

ATOM 18665 O PHE E 154 60. ,548 -50. 083 -33. 940 1.00 27. ,95 E 0

ATOM 18667 N PRO E 155 59. ,450 -48. 829 -35. 448 1.00 30. ,79 E N

ATOM 18668 CA PRO E 155 58. ,497 -47. 835 -35. 890 1.00 32. ,00 E c

ATOM 18670 CB PRO E 155 59. ,002 -47. 496 -37. 294 1.00 31. ,04 E c

ATOM 18673 CG PRO E 155 59. ,542 -48. 773 -37. ,803 1.00 28. ,39 E c

ATOM 18676 CD PRO E 155 60. ,013 -49. 566 -36. 591 1.00 30. ,49 E c

ATOM 18679 C PRO E 155 57. ,091 -48. 434 -35. ,946 1.00 33. ,16 E c

ATOM 18680 O PRO E 155 56. ,851 -49. 534 -35. ,440 1.00 31. ,05 E 0

ATOM 18681 N GLU E 156 56. ,162 -47. 714 -36. ,554 1.00 32. ,87 E N

ATOM 18682 CA GLU E 156 54. ,917 -48. 330 -36. ,961 1.00 33. ,62 E C

ATOM 18684 CB GLU E 156 53. ,915 -47. 262 -37. ,389 1.00 35. ,87 E C

ATOM 18687 CG GLU E 156 53. ,385 -46. 403 -36. 242 1.00 33. ,75 E c

ATOM 18690 CD GLU E 156 52. ,083 -46. 934 -35. 648 1.00 35. ,68 E c

ATOM 18691 OEl GLU E 156 51. ,972 -48. 155 -35. 399 1.00 33. ,85 E 0

ATOM 18692 OE2 GLU E 156 51. ,168 -46. 115 -35. ,412 1.00 36. ,28 E 0

ATOM 18693 C GLU E 156 55. ,225 -49. 305 -38. ,110 1.00 35. ,08 E c

ATOM 18694 0 GLU E 156 56. ,282 -49. 208 -38. ,755 1.00 31. ,84 E 0

ATOM 18696 N PRO E 157 54. ,318 -50. 262 -38. 369 1.00 34. ,40 E N

ATOM 18697 CA PRO E 157 53. ,081 -50. 578 -37. 677 1.00 34. ,61 E c

ATOM 18699 CB PRO E 157 52. ,146 -50. 878 -38. ,840 1.00 35. ,02 E c

ATOM 18702 CG PRO E 157 53. ,058 -51. 570 -39. ,844 1.00 35. ,97 E c

ATOM 18705 CD PRO E 157 54. ,476 -51. 113 -39. ,563 1.00 34. ,44 E c

ATOM 18708 C PRO E 157 53. ,166 -51. 831 -36. 795 1.00 35. ,21 E c

ATOM 18709 0 PRO E 157 54. ,147 -52. 580 -36. ,854 1.00 31. ,58 E 0

ATOM 18710 N VAL E 158 52. ,130 -52. 038 -35. ,986 1.00 33. ,76 E N

ATOM 18711 CA VAL E 158 51. ,852 -53. 341 -35. ,411 1.00 35. ,15 E c

ATOM 18713 CB VAL E 158 51. ,933 -53. 362 -33. ,867 1.00 34. ,07 E c

ATOM 18715 CGI VAL E 158 53. ,327 -53. 026 -33. ,410 1.00 30. ,82 E c

ATOM 18719 CG2 VAL E 158 50. ,890 -52. 443 -33. ,246 1.00 33. ,68 E c

ATOM 18723 C VAL E 158 50. ,463 -53. 790 -35. ,824 1.00 35. ,73 E c

ATOM 18724 0 VAL E 158 49. ,580 -52. 968 -36. ,088 1.00 39. ,78 E 0

ATOM 18726 N THR E 159 50. ,281 -55. 102 -35. ,880 1.00 37. ,31 E N

ATOM 18727 CA THR E 159 48. ,973 -55. 694 -36. ,094 1.00 39. ,31 E c

ATOM 18729 CB THR E 159 48. .985 -56. 643 -37. ,297 1.00 41. ,40 E c

ATOM 18731 OGl THR E 159 49. ,816 -57. 773 -37. ,014 1.00 42. ,78 E 0

ATOM 18733 CG2 THR E 159 49. ,512 -55. 923 -38. ,528 1.00 44. ,06 E c

ATOM 18737 C THR E 159 48. ,564 -56. 441 -34. ,828 1.00 39. ,96 E c

ATOM 18738 0 THR E 159 49. ,409 -56. 994 -34. ,122 1.00 39, ,87 E 0

ATOM 18740 N VAL E 160 47. ,273 -56. 411 -34. ,516 1.00 38. ,99 E N

ATOM 18741 CA VAL E 160 46. ,759 -57. 155 -33. ,393 1.00 38. ,17 E c

ATOM 18743 CB VAL E 160 46. ,479 -56. 256 -32. ,186 1.00 33. ,68 E c

ATOM 18745 CGI VAL E 160 45. ,829 -57. 064 -31. ,071 1.00 29. ,21 E c

ATOM 18749 CG2 VAL E 160 47. ,768 -55. 614 -31. ,711 1.00 29. ,66 E c

ATOM 18753 C VAL E 160 45. ,489 -57. 874 -33. ,804 1.00 39. ,99 E c

ATOM 18754 0 VAL E 160 44. ,602 -57. 273 -34. ,403 1.00 40. .72 E 0

ATOM 18756 N SER E 161 45. ,430 -59. 170 -33. ,490 1.00 41. .77 E N

ATOM 18757 CA SER E 161 44. ,238 -59. 980 -33. ,716 1.00 40. .45 E c

ATOM 18759 CB SER E 161 44. ,451 -60. 952 -34. ,889 1.00 42. ,58 E c

ATOM 18762 OG SER E 161 45. ,245 -62. 067 -34, ,511 1.00 44. .51 E 0

ATOM 18764 C SER E 161 43. ,907 -60. 732 -32, ,431 1.00 37. ,42 E c

ATOM 18765 0 SER E 161 44. ,692 -60. 726 -31. ,490 1.00 36. ,94 E 0

ATOM 18767 N TRP E 162 42. ,739 -61. 361 -32. ,398 1.00 37. ,33 E N

ATOM 18768 CA TRP E 162 42. ,286 -62. 087 -31. ,223 1.00 38. ,56 E C

ATOM 18770 CB TRP E 162 41. ,120 -61. 347 -30. ,564 1.00 35. ,69 E c cyno fD_Fab

ATOM 18773 CG TRP E 162 41. ,560 -60. 151 -29. ,778 1. 00 34. 58 E C

ATOM 18774 CDl TRP E 162 41. ,674 -58. 869 -30. ,228 1. 00 34. 95 E C

ATOM 18776 NEl TRP E 162 42. ,112 -58. 047 -29. ,215 1. 00 34. 98 E N

ATOM 18778 CE2 TRP E 162 42. ,296 -58. 797 -28. ,086 1. 00 35. 16 E C

ATOM 18779 CD2 TRP E 162 41. ,964 -60. 131 -28. ,405 1. 00 33. 31 E C

ATOM 18780 CE3 TRP E 162 42. ,066 -61. 106 -27. ,410 1. 00 33. 47 E c

ATOM 18782 CZ3 TRP E 162 42. ,496 -60. 732 -26.157 1. 00 34. 55 E c

ATOM 18784 CH2 TRP E 162 42. ,818 -59. 400 -25. 869 1. 00 34. ,77 E c

ATOM 18786 CZ2 TRP E 162 42. ,728 -58. 419 -26. ,818 1. 00 35. 21 E c

ATOM 18788 C TRP E 162 41. 877 -63. 504 -31. 609 1. 00 39. 26 E c

ATOM 18789 O TRP E 162 41. ,060 -63. 686 -32. ,509 1. 00 40. 39 E 0

ATOM 18791 N ASN E 163 42. 450 -64. 488 -30. ,913 1. 00 41.68 E N

ATOM 18792 CA ASN E 163 42. 261 -65. 911 -31. ,219 1. 00 39. 55 E c

ATOM 18794 CB ASN E 163 40. ,859 -66. 374 -30. ,800 1. 00 36. 73 E c

ATOM 18797 CG ASN E 163 40. ,600 -66. 182 -29. ,309 1. 00 33. 82 E c

ATOM 18798 ODl ASN E 163 41. ,524 -65. 970 -28. ,528 1. 00 31. 78 E 0

ATOM 18799 ND2 ASN E 163 39. ,335 -66. 257 -28. ,915 1. 00 32. 40 E N

ATOM 18802 C ASN E 163 42. 534 -66. 200 -32. ,700 1. 00 39. 71 E c

ATOM 18803 O ASN E 163 41. 662 -66. 665 -33. ,434 1. 00 37. 18 E 0

ATOM 18805 N SER E 164 43. 761 -65. 887 -33. ,118 1. 00 41. 23 E N

ATOM 18806 CA SER E 164 44. 242 -66. 078 -34. ,490 1. 00 40. 93 E C

ATOM 18808 CB SER E 164 44. 702 -67. 530 -34. ,692 1. 00 39. 75 E c

ATOM 18811 OG SER E 164 45. 615 -67. 927 -33. ,681 1. 00 38. 55 E 0

ATOM 18813 C SER E 164 43. 222 -65. 698 -35. ,564 1. 00 41. 73 E C

ATOM 18814 O SER E 164 43. ,120 -66. 372 -36. ,585 1. 00 46. 96 E 0

ATOM 18816 N GLY E 165 42. 470 -64. 626 -35. ,330 1. 00 42. 46 E N

ATOM 18817 CA GLY E 165 41. 473 -64. 143 -36. ,290 1. 00 40. 94 E c

ATOM 18820 C GLY E 165 40. 040 -64. 595 -36. ,036 1. 00 39. 15 E c

ATOM 18821 O GLY E 165 39. 118 -64. 119 -36. ,699 1. 00 33. 06 E 0

ATOM 18823 N ALA E 166 39. 849 -65. 504 -35. ,082 1. 00 40. 21 E N

ATOM 18824 CA ALA E 166 38. 524 -66. 048 -34. ,781 1. 00 41. 74 E c

ATOM 18826 CB ALA E 166 38. 637 -67. 263 -33. ,855 1. 00 43. 12 E c

ATOM 18830 C ALA E 166 37. 617 -64. 990 -34. ,163 1. 00 43. 83 E c

ATOM 18831 O ALA E 166 36. ,494 -64. 794 -34. ,620 1. 00 46. 56 E 0

ATOM 18833 N LEU E 167 38. 114 -64. 306 -33. ,134 1. 00 43. 98 E N

ATOM 18834 CA LEU E 167 37. 348 -63. 264 -32. ,439 1. 00 42. 38 E c

ATOM 18836 CB LEU E 167 37. 821 -63. 154 -30. 985 1. 00 40. 80 E c

ATOM 18839 CG LEU E 167 37. 052 -62. 262 -30. ,010 1. 00 39. 56 E c

ATOM 18841 CDl LEU E 167 35. 575 -62. 612 -29. ,982 1. 00 38. 05 E c

ATOM 18845 CD2 LEU E 167 37. 655 -62. 385 -28. ,620 1. 00 37. 96 E c

ATOM 18849 C LEU E 167 37. 484 -61. 915 -33. ,161 1. 00 42. 08 E c

ATOM 18850 O LEU E 167 38. 579 -61. 392 -33. ,322 1. 00 43. 31 E 0

ATOM 18852 N THR E 168 36. 370 -61. 365 -33. ,625 1. 00 41. 17 E N

ATOM 18853 CA THR E 168 36. ,398 -60. 067 -34. ,291 1. 00 41. 92 E C

ATOM 18855 CB THR E 168 36. 339 -60. 228 -35. ,823 1. 00 44. 57 E c

ATOM 18857 OGl THR E 168 35. ,184 -60. 989 -36. ,185 1. 00 48. 75 E 0

ATOM 18859 CG2 THR E 168 37. ,570 -60. 952 -36. ,326 1. 00 43. 31 E c

ATOM 18863 C THR E 168 35. ,300 -59. 126 -33. ,787 1. 00 39. 87 E c

ATOM 18864 O THR E 168 35. ,492 -57. 908 -33. ,767 1. 00 41. 47 E 0

ATOM 18866 N SER E 169 34. ,173 -59. 692 -33. ,363 1. 00 40. 66 E N

ATOM 18867 CA SER E 169 33. ,077 -58. 935 -32. ,754 1. 00 41. 25 E c

ATOM 18869 CB SER E 169 31. ,859 -59. 849 -32, ,544 1. 00 44. 19 E c

ATOM 18872 OG SER E 169 30. ,863 -59. 217 -31, .746 1. 00 45. ,75 E 0

ATOM 18874 C SER E 169 33. ,458 -58. 292 -31, .413 1. 00 41. ,52 E c

ATOM 18875 O SER E 169 33. ,912 -58. 976 -30. ,487 1. 00 43. ,81 E 0

ATOM 18877 N GLY E 170 33. ,246 -56. 980 -31. ,306 1. 00 38. ,63 E N

ATOM 18878 CA GLY E 170 33. ,504 -56. 245 -30. ,061 1. 00 34. ,79 E c

ATOM 18881 C GLY E 170 34. ,944 -55. 785 -29. .898 1. 00 32. 86 E c

ATOM 18882 O GLY E 170 35. ,291 -55. 180 -28, ,878 1. 00 35. 36 E 0

ATOM 18884 N VAL E 171 35. ,781 -56. 058 -30, ,900 1. 00 29. 09 E N

ATOM 18885 CA VAL E 171 37. ,205 -55. 723 -30. ,839 1. 00 31. ,14 E c

ATOM 18887 CB VAL E 171 38. ,048 -56. 678 -31.723 1. 00 30. 94 E c

ATOM 18889 CGl VAL E 171 39. ,447 -56. 119 -31, ,950 1. ,00 31.05 E c

ATOM 18893 CG2 VAL E 171 38. .127 -58. 065 -31, .088 1. 00 23. 30 E c

ATOM 18897 C VAL E 171 37. ,476 -54. 273 -31, .254 1. 00 29. 63 E c

ATOM 18898 O VAL E 171 37. 095 -53. 845 -32, .336 1. 00 32. ,72 E 0

ATOM 18900 N HIS E 172 38. .154 -53. 530 -30, ,386 1. 00 30. ,49 E N

ATOM 18901 CA HIS E 172 38. ,574 -52. 171 -30, .697 1. 00 28. ,98 E c cyno fD_Fab

ATOM 18903 CB HIS E 172 37. 820 -51.152 -29. ,826 1. 00 29. 81 E C

ATOM 18906 CG HIS E 172 36. 337 -51. ,132 -30. ,056 1. 00 27. 94 E C

ATOM 18907 NDl HIS E 172 35. 774 -50. ,675 -31. ,227 1. 00 26. 24 E N

ATOM 18909 CEl HIS E 172 34. 457 -50. ,773 -31. ,148 1. 00 29. ,34 E C

ATOM 18911 NE2 HIS E 172 34. 142 -51. ,278 -29. ,969 1. 00 22. 78 E N

ATOM 18913 CD2 HIS E 172 35. 301 -51. ,503 -29. 262 1. 00 28. 15 E C

ATOM 18915 C HIS E 172 40. 075 -52. ,069 -30. ,484 1. 00 27. 28 E C

ATOM 18916 O HIS E 172 40. 550 -52. ,072 -29. ,350 1. 00 30. 94 E 0

ATOM 18918 N THR E 173 40. 819 -52. ,047 -31. ,580 1. 00 24. 01 E N

ATOM 18919 CA THR E 173 42. 260 -51. ,858 -31. ,537 1. 00 28. 19 E C

ATOM 18921 CB THR E 173 43. 019 -52. ,671 -32. ,620 1. 00 25. 38 E c

ATOM 18923 OGl THR E 173 42. 863 -54. ,076 -32. ,368 1. 00 24. 79 E 0

ATOM 18925 CG2 THR E 173 44. 529 -52. ,329 -32. ,618 1. 00 21. 83 E c

ATOM 18929 C THR E 173 42. 481 -50. ,386 -31. ,746 1. 00 28. 81 E c

ATOM 18930 O THR E 173 42. 109 -49. ,843 -32. ,785 1. 00 26. 67 E 0

ATOM 18932 N PHE E 174 43. 070 -49. ,735 -30. ,746 1. 00 30. 91 E N

ATOM 18933 CA PHE E 174 43. 223 -48. ,293 -30. ,791 1. 00 30. 94 E c

ATOM 18935 CB PHE E 174 43. 320 -47. ,719 -29. ,386 1. 00 26. 21 E c

ATOM 18938 CG PHE E 174 42. 031 -47. ,807 -28. ,649 1. 00 27. 92 E c

ATOM 18939 CDl PHE E 174 41. 067 -46. ,842 -28. ,817 1. 00 27. 82 E c

ATOM 18941 CEl PHE E 174 39. 860 -46. ,938 -28. ,175 1. 00 27. 43 E c

ATOM 18943 CZ PHE E 174 39. 593 -48. ,002 -27. ,363 1. 00 26. 64 E c

ATOM 18945 CE2 PHE E 174 40. 537 -48. ,982 -27. ,200 1. 00 28. 38 E c

ATOM 18947 CD 2 PHE E 174 41.743 -48. ,894 -27. ,854 1. 00 28. 25 E c

ATOM 18949 C PHE E 174 44. 397 -47. ,871 -31.648 1. 00 31. 48 E c

ATOM 18950 O PHE E 174 45. 348 -48. ,637 -31. ,824 1. 00 29. 64 E 0

ATOM 18952 N PRO E 175 44. 305 -46. ,664 -32. ,232 1. 00 33. 05 E N

ATOM 18953 CA PRO E 175 45. 422 -46. ,088 -32. ,960 1. 00 33. 41 E c

ATOM 18955 CB PRO E 175 44. 865 -44. ,758 -33. ,479 1. 00 33. 29 E c

ATOM 18958 CG PRO E 175 43. 404 -44. ,877 -33. ,397 1. 00 33. 19 E c

ATOM 18961 CD PRO E 175 43. 112 -45. ,799 -32. ,279 1. 00 32. 95 E c

ATOM 18964 C PRO E 175 46. 616 -45. 835 -32. ,051 1. 00 34. 20 E c

ATOM 18965 O PRO E 175 46. 442 -45. ,366 -30. ,929 1. 00 29. 88 E 0

ATOM 18966 N ALA E 176 47. 817 -46. ,138 -32. ,539 1. 00 37. 51 E N

ATOM 18967 CA ALA E 176 49. 029 -45. ,943 -31. ,758 1. 00 35. 53 E c

ATOM 18969 CB ALA E 176 50. 240 -46. ,461 -32. ,516 1. 00 33. 45 E c

ATOM 18973 C ALA E 176 49. 195 -44. 470 -31. 417 1. 00 38. 39 E c

ATOM 18974 O ALA E 176 48. 894 -43. 609 -32. ,237 1. 00 45. 13 E 0

ATOM 18976 N VAL E 177 49. 625 -44. 196 -30. 188 1. 00 39. 30 E N

ATOM 18977 CA VAL E 177 50. 039 -42. 858 -29. 773 1. 00 38. 84 E c

ATOM 18979 CB VAL E 177 49. 408 -42. 428 -28. ,419 1. 00 40. 28 E c

ATOM 18981 CGI VAL E 177 47. 890 -42. ,494 -28. ,491 1. 00 40. 32 E c

ATOM 18985 CG2 VAL E 177 49. 958 -43. ,276 -27. ,242 1. 00 44. 64 E c

ATOM 18989 C VAL E 177 51. 556 -42. ,835 -29. ,651 1. 00 36. 47 E c

ATOM 18990 O VAL E 177 52. 173 -43. ,847 -29. ,303 1. 00 33. 37 E 0

ATOM 18992 N LEU E 178 52. 146 -41. ,680 -29. ,955 1. 00 37. 78 E N

ATOM 18993 CA LEU E 178 53. 579 -41. ,465 -29. ,802 1. 00 38. 62 E c

ATOM 18995 CB LEU E 178 54. 118 -40. ,529 -30. ,879 1. 00 37. 67 E c

ATOM 18998 CG LEU E 178 55. 623 -40. ,251 -30. ,871 1. 00 38. ,72 E c

ATOM 19000 CDl LEU E 178 56. 415 -41. ,538 -30. ,998 1. 00 37. 20 E c

ATOM 19004 CD2 LEU E 178 55. 968 -39. ,273 -32. ,003 1. 00 40. 29 E c

ATOM 19008 C LEU E 178 53. 824 -40. ,872 -28. ,427 1. 00 40. 63 E c

ATOM 19009 O LEU E 178 53. 267 -39. ,830 -28. ,071 1. 00 41. 50 E 0

ATOM 19011 N GLN E 179 54. 665 -41. .549 -27. .660 1. 00 41.56 E N

ATOM 19012 CA GLN E 179 54. 929 -41. ,180 -26. .285 1. 00 41. 85 E C

ATOM 19014 CB GLN E 179 55. 263 -42. .432 -25. ,474 1. 00 41. 75 E C

ATOM 19017 CG GLN E 179 54. 176 -43. ,496 -25. ,518 1. 00 39. 42 E c

ATOM 19020 CD GLN E 179 54. 600 -44. ,787 -24. ,868 1. 00 40. 97 E c

ATOM 19021 OEl GLN E 179 55. 514 -45. ,463 -25. ,338 1. 00 40. 18 E 0

ATOM 19022 NE2 GLN E 179 53. 930 -45. ,142 -23. ,779 1. 00 43. 22 E N

ATOM 19025 C GLN E 179 56. 077 -40. ,186 -26. ,230 1. 00 43. 47 E c

ATOM 19026 O GLN E 179 56. 825 -40. ,028 -27. ,203 1. 00 42. 57 E 0

ATOM 19028 N SER E 180 56. 205 -39. .522 -25. .082 1. 00 44. 23 E N

ATOM 19029 CA SER E 180 57. 298 -38, .583 -24, .828 1. ,00 43. 65 E c

ATOM 19031 CB SER E 180 57. 247 -38. .108 -23, ,374 1. 00 46. 02 E c

ATOM 19034 OG SER E 180 57. 536 -39. .177 -22, .479 1. 00 47. 23 E 0

ATOM 19036 C SER E 180 58. 660 -39. ,221 -25, .116 1. 00 45. ,02 E c

ATOM 19037 O SER E 180 59. 596 -38. .542 -25, .545 1. 00 47. 95 E 0 cyno fD..Fab

ATOM 19039 N SER E 181 58. ,755 -40. ,531 -24. ,883 1.00 42. ,92 E N

ATOM 19040 CA SER E 181 59. ,989 -41. 285 -25. ,095 1.00 40. ,43 E C

ATOM 19042 CB SER E 181 59. ,874 -42. ,664 -24. ,434 1.00 39. ,42 E C

ATOM 19045 OG SER E 181 58. ,759 -43. ,388 -24. ,930 1.00 35. ,25 E 0

ATOM 19047 C SER E 181 60. 372 -41.462 -26. ,565 1.00 40. ,16 E c

ATOM 19048 O SER E 181 61. 508 -41. 841 -26. ,862 1.00 40. ,98 E 0

ATOM 19050 N GLY E 182 59. 433 -41. 205 -27. ,475 1.00 38. ,39 E N

ATOM 19051 CA GLY E 182 59. 661 -41. 406 -28. ,908 1.00 37. ,70 E c

ATOM 19054 C GLY E 182 59. 296 -42. 804 -29. 382 1.00 38. 29 E C

ATOM 19055 O GLY E 182 59. 603 -43. 178 -30. ,515 1.00 38. ,75 E 0

ATOM 19057 N LEU E 183 58. ,647 -43. 574 -28. ,507 1.00 37. ,09 E N

ATOM 19058 CA LEU E 183 58. ,152 -44. 907 -28. ,828 1.00 34. ,19 E c

ATOM 19060 CB LEU E 183 58. ,618 -45. 923 -27. ,797 1.00 33. ,25 E c

ATOM 19063 CG LEU E 183 60. ,050 -46. 441 -27. ,884 1.00 35. 69 E c

ATOM 19065 CDl LEU E 183 61. 073 -45. 320 -27. ,918 1.00 39. ,92 E c

ATOM 19069 CD2 LEU E 183 60. 296 -47. 326 -26. ,692 1.00 33. ,46 E c

ATOM 19073 C LEU E 183 56. 637 -44. 911 -28. ,842 1.00 33. 58 E c

ATOM 19074 O LEU E 183 55. 994 -44. 156 -28. ,112 1.00 32. 34 E 0

ATOM 19076 N TYR E 184 56. 065 -45. 791 -29. ,651 1.00 31. 66 E N

ATOM 19077 CA TYR E 184 54. 617 -45. 900 -29. ,736 1.00 32. ,97 E c

ATOM 19079 CB TYR E 184 54. 196 -46. 408 -31.117 1.00 36. ,59 E c

ATOM 19082 CG TYR E 184 54. ,494 -45. 426 -32. ,212 1.00 37. 52 E c

ATOM 19083 CDl TYR E 184 53. 611 -44. 388 -32. ,494 1.00 36. 93 E c

ATOM 19085 CEl TYR E 184 53. 885 -43. 471 -33. ,489 1.00 37. ,48 E c

ATOM 19087 CZ TYR E 184 55. 057 -43. 588 -34. ,216 1.00 37. ,66 E c

ATOM 19088 OH TYR E 184 55. 326 -42. 684 -35. ,212 1.00 39. ,64 E 0

ATOM 19090 CE2 TYR E 184 55. 949 -44. 603 -33. ,955 1.00 36. ,51 E c

ATOM 19092 CD2 TYR E 184 55. 669 -45. 514 -32. ,952 1.00 38. 00 E c

ATOM 19094 C TYR E 184 54. 067 -46. 812 -28. ,657 1.00 31. ,41 E c

ATOM 19095 0 TYR E 184 54. 793 -47. 596 -28. ,044 1.00 29. ,10 E 0

ATOM 19097 N SER E 185 52. 768 -46. 691 -28. ,424 1.00 32. ,98 E N

ATOM 19098 CA SER E 185 52. 059 -47. 610 -27. ,549 1.00 31. 99 E c

ATOM 19100 CB SER E 185 52. 141 -47. 134 -26. ,094 1.00 33. 98 E c

ATOM 19103 OG SER E 185 51. 361 -47. 944 -25. ,226 1.00 34. ,21 E 0

ATOM 19105 C SER E 185 50. 624 -47. 676 -28. ,023 1.00 29. ,77 E c

ATOM 19106 0 SER E 185 50. 081 -46. 674 -28. ,462 1.00 29. ,91 E 0

ATOM 19108 N LEU E 186 50. 021 -48. 858 -27. ,979 1.00 30. ,81 E N

ATOM 19109 CA LEU E 186 48. 592 -48. 984 -28. ,270 1.00 29. ,55 E C

ATOM 19111 CB LEU E 186 48. 339 -49. 200 -29. ,772 1.00 29. ,14 E c

ATOM 19114 CG LEU E 186 48. 576 -50. 538 -30. 469 1.00 27. ,70 E c

ATOM 19116 CDl LEU E 186 47. 589 -51. 627 -30. 041 1.00 27. ,64 E c

ATOM 19120 CD2 LEU E 186 48. 476 -50. 304 -31.957 1.00 23. ,42 E c

ATOM 19124 C LEU E 186 47. 918 -50. 068 -27. ,454 1.00 29. ,18 E c

ATOM 19125 0 LEU E 186 48. 567 -50. 931 -26. 884 1.00 29. ,53 E 0

ATOM 19127 N SER E 187 46. 596 -49. 992 -27. ,412 1.00 32. ,17 E N

ATOM 19128 CA SER E 187 45. 780 -50. 958 -26. ,715 1.00 29. ,61 E c

ATOM 19130 CB SER E 187 44. 979 -50. 263 -25. ,621 1.00 33. ,26 E c

ATOM 19133 OG SER E 187 44. 800 -51.125 -24. ,515 1.00 40. ,95 E 0

ATOM 19135 C SER E 187 44. 832 -51. 590 -27. ,710 1.00 28. ,97 E c

ATOM 19136 0 SER E 187 44. 421 -50. 962 -28. ,676 1.00 27. ,57 E 0

ATOM 19138 N SER E 188 44. 505 -52. 850 -27. ,479 1.00 32. ,42 E N

ATOM 19139 CA SER E 188 43. 460 -53. 525 -28. ,224 1.00 27. ,47 E c

ATOM 19141 CB SER E 188 44. 028 -54. 604 -29. ,141 1.00 27. ,77 E c

ATOM 19144 OG SER E 188 42. 996 -55. 174 -29. ,932 1.00 27. ,63 E 0

ATOM 19146 C SER E 188 42. 543 -54. 135 -27. ,198 1.00 27. ,43 E c

ATOM 19147 0 SER E 188 42. 976 -54. 949 -26. ,384 1.00 31. ,91 E 0

ATOM 19149 N VAL E 189 41. 288 -53. ,708 -27. ,210 1.00 27. ,76 E N

ATOM 19150 CA VAL E 189 40. 291 -54. 226 -26. ,288 1.00 27. ,31 E c

ATOM 19152 CB VAL E 189 39. ,566 -53. 096 -25. .513 1.00 25, ,78 E c

ATOM 19154 CGI VAL E 189 40. 550 -52. ,342 -24. ,593 1.00 24, ,18 E c

ATOM 19158 CG2 VAL E 189 38. 871 -52. 148 -26. ,462 1.00 20. ,58 E c

ATOM 19162 C VAL E 189 39. 267 -55. 059 -27. ,046 1.00 29. ,41 E c

ATOM 19163 0 VAL E 189 39. 140 -54. 961 -28. ,275 1.00 30. ,71 E 0

ATOM 19165 N VAL E 190 38. 582 -55. 918 -26. ,301 1.00 28. ,75 E N

ATOM 19166 CA VAL E 190 37. 430 -56. 640 -26. ,811 1.00 28. 68 E c

ATOM 19168 CB VAL E 190 37. 812 -58. 010 -27. ,455 1.00 25. ,83 E c

ATOM 19170 CGI VAL E 190 38. 337 -58. 999 -26. ,405 1.00 23. ,01 E c

ATOM 19174 CG2 VAL E 190 36. ,618 -58. ,598 -28. .187 1.00 25. ,43 E c cyno fD_Fab

ATOM 19178 C VAL E 190 36. ,446 -56. 826 -25. ,665 1.00 28. ,03 E C

ATOM 19179 O VAL E 190 36. .850 -57. 039 -24. ,518 1.00 24. ,88 E 0

ATOM 19181 N THR E 191 35. ,157 -56. 691 -25. 969 1.00 33. ,99 E N

ATOM 19182 CA THR E 191 34. ,109 -57. 015 -25. 001 1.00 32. ,71 E C

ATOM 19184 CB THR E 191 33. ,000 -55. 947 -24. 932 1.00 34. ,46 E C

ATOM 19186 OGl THR E 191 32. ,706 -55. 470 -26. ,252 1.00 35. ,11 E 0

ATOM 19188 CG2 THR E 191 33. ,432 -54. 786 -24. 037 1.00 31. 69 E C

ATOM 19192 C THR E 191 33. ,499 -58. 362 -25. ,352 1.00 33. ,75 E c

ATOM 19193 O THR E 191 33. ,254 -58. 677 -26. ,525 1.00 34. ,60 E 0

ATOM 19195 N VAL E 192 33. ,281 -59. 150 -24. ,310 1.00 35. ,15 E N

ATOM 19196 CA VAL E 192 32. ,743 -60. 490 -24. ,414 1.00 35. ,77 E c

ATOM 19198 CB VAL E 192 33. ,851 -61. 557 -24. ,231 1.00 31. ,08 E c

ATOM 19200 CGI VAL E 192 34. ,944 -61. 406 -25. 293 1.00 22. ,78 E c

ATOM 19204 CG2 VAL E 192 34. ,458 -61. 474 -22. ,837 1.00 26. ,54 E c

ATOM 19208 C VAL E 192 31. ,732 -60. 618 -23. 286 1.00 38. 94 E c

ATOM 19209 O VAL E 192 31. ,725 -59. 786 -22. ,380 1.00 43. ,53 E 0

ATOM 19211 N PRO E 193 30. ,861 -61. 639 -23. ,335 1.00 40. ,85 E N

ATOM 19212 CA PRO E 193 30. ,013 -61. 909 -22. ,163 1.00 39. ,64 E c

ATOM 19214 CB PRO E 193 29. 158 -63. 100 -22. 610 1.00 39. ,94 E c

ATOM 19217 CG PRO E 193 29. 204 -63. 064 -24. ,116 1.00 41. ,62 E c

ATOM 19220 CD PRO E 193 30. ,570 -62. 556 -24. ,452 1.00 40. ,08 E c

ATOM 19223 C PRO E 193 30. ,813 -62. 263 -20. ,906 1.00 40. ,97 E c

ATOM 19224 O PRO E 193 31. ,916 -62. 803 -21. ,001 1.00 41.96 E 0

ATOM 19225 N SER E 194 30. 255 -61. 948 -19. ,737 1.00 42. ,70 E N

ATOM 19226 CA SER E 194 30. ,847 -62. 342 -18. ,454 1.00 44. ,61 E c

ATOM 19228 CB SER E 194 30. 069 -61. 712 -17. ,290 1.00 45. 69 E C

ATOM 19231 OG SER E 194 30. 261 -60. 310 -17. 231 1.00 45. ,41 E 0

ATOM 19233 C SER E 194 30. 861 -63. 868 -18. ,273 1.00 45. 36 E c

ATOM 19234 O SER E 194 31. 709 -64. 410 -17. ,568 1.00 38. ,09 E 0

ATOM 19236 N SER E 195 29. 897 -64. 537 -18. ,905 1.00 49. ,26 E N

ATOM 19237 CA SER E 195 29. 755 -65. 989 -18. ,855 1.00 49. ,05 E C

ATOM 19239 CB SER E 195 28. 452 -66. 392 -19. ,548 1.00 50. ,36 E C

ATOM 19242 OG SER E 195 27. 364 -65. 643 -19. 039 1.00 50. ,11 E 0

ATOM 19244 C SER E 195 30. 921 -66. 705 -19. ,530 1.00 49. ,31 E C

ATOM 19245 O SER E 195 31. 355 -67. 767 -19. ,076 1.00 46. ,72 E 0

ATOM 19247 N SER E 196 31. ,424 -66. 109 -20. ,610 1.00 48. ,32 E N

ATOM 19248 CA SER E 196 32. ,483 -66. 715 -21.411 1.00 49. ,47 E c

ATOM 19250 CB SER E 196 32. ,607 -65. 991 -22. ,755 1.00 50. ,33 E c

ATOM 19253 OG SER E 196 33. 441 -64. 848 -22. ,631 1.00 48. ,99 E 0

ATOM 19255 C SER E 196 33. 857 -66. 708 -20. ,741 1.00 50. ,79 E c

ATOM 19256 O SER E 196 34. 753 -67. 423 -21. ,187 1.00 53. ,27 E 0

ATOM 19258 N LEU E 197 34. 036 -65. 900 -19. ,697 1.00 50. ,67 E N

ATOM 19259 CA LEU E 197 35. 374 -65. 646 -19. ,148 1.00 50. ,78 E c

ATOM 19261 CB LEU E 197 35. 324 -64. 629 -17. ,991 1.00 47. ,28 E c

ATOM 19264 CG LEU E 197 35. 356 -63. 150 -18. ,403 1.00 43. ,24 E c

ATOM 19266 CDl LEU E 197 35. 177 -62. 249 -17. ,195 1.00 41. ,58 E c

ATOM 19270 CD2 LEU E 197 36. ,652 -62. 812 -19. ,126 1.00 41. ,70 E c

ATOM 19274 C LEU E 197 36. 096 -66. 921 -18. ,715 1.00 53. ,03 E c

ATOM 19275 O LEU E 197 37. ,155 -67. 250 -19. ,261 1.00 54. ,58 E 0

ATOM 19277 N GLY E 198 35. ,518 -67. 629 -17. ,747 1.00 52. ,83 E N

ATOM 19278 CA GLY E 198 36. 096 -68. 872 -17. ,234 1.00 54. ,16 E c

ATOM 19281 C GLY E 198 36. ,186 -69. 973 -18. 278 1.00 55. ,07 E c

ATOM 19282 O GLY E 198 37. ,159 -70. 728 -18. 309 1.00 55. ,44 E 0

ATOM 19284 N THR E 199 35. ,168 -70. 055 -19. 132 1.00 54. ,51 E N

ATOM 19285 CA THR E 199 35. ,113 -71. 040 -20. 213 1.00 53. ,83 E C

ATOM 19287 CB THR E 199 33. 701 -71. 070 -20. ,852 1.00 55. ,74 E c

ATOM 19289 OGl THR E 199 32. 809 -71. 778 -19. 988 1.00 57. ,29 E 0

ATOM 19291 CG2 THR E 199 33. 713 -71. 734 -22. 233 1.00 55. ,26 E C

ATOM 19295 C THR E 199 36. 144 -70. 776 -21. ,314 1.00 54. ,93 E c

ATOM 19296 O THR E 199 37. ,101 -71. 539 -21. ,476 1.00 55. ,55 E 0

ATOM 19298 N GLN E 200 35. ,941 -69. 686 -22. ,054 1.00 53. ,15 E N

ATOM 19299 CA GLN E 200 36. ,660 -69. 422 -23. ,297 1.00 49. ,21 E C

ATOM 19301 CB GLN E 200 35. ,836 -68. 464 -24. ,159 1.00 52. ,98 E c

ATOM 19304 CG GLN E 200 36. ,422 -68. 142 -25. ,541 1.00 55. ,83 E c

ATOM 19307 CD GLN E 200 36. ,541 -69. 357 -26. ,445 1.00 57. ,96 E c

ATOM 19308 OEl GLN E 200 35. ,848 -70. 362 -26. ,258 1.00 60. ,60 E 0

ATOM 19309 NE2 GLN E 200 37. ,421 -69. 267 -27. ,438 1.00 57. ,40 E N

ATOM 19312 C GLN E 200 38. 057 -68. 853 -23. ,065 1.00 46, ,45 E c cyno fD_Fab

ATOM 19313 O GLN E 200 38 295 -68, ,135 -22. ,095 1.00 47. ,37 E 0

ATOM 19315 N THR E 201 38 974 -69. .181 -23. ,972 1.00 43. 88 E N

ATOM 19316 CA THR E 201 40 351 -68. ,695 -23. ,909 1.00 42. 86 E C

ATOM 19318 CB THR E 201 41 341 -69. ,806 -24. 303 1.00 42. 43 E C

ATOM 19320 OGl THR E 201 41.207 -70. ,899 -23. 386 1.00 43. 67 E 0

ATOM 19322 CG2 THR E 201 42 790 -69. .309 -24. ,275 1.00 41. 67 E c

ATOM 19326 C THR E 201 40 526 -67, .480 -24. ,821 1.00 40. 23 E c

ATOM 19327 O THR E 201 40 157 -67, .523 -26. ,002 1.00 41. 83 E 0

ATOM 19329 N TYR E 202 41 072 -66. .398 -24. ,263 1.00 36. 97 E N

ATOM 19330 CA TYR E 202 41 293 -65. ,157 -25. ,015 1.00 36. 22 E c

ATOM 19332 CB TYR E 202 40 550 -63, ,990 -24. ,370 1.00 33. 84 E c

ATOM 19335 CG TYR E 202 39 047 -64, ,168 -24. ,408 1.00 33. 82 E c

ATOM 19336 CDl TYR E 202 38 355 -64, ,103 -25. 611 1.00 32. 06 E c

ATOM 19338 CEl TYR E 202 36 984 -64, ,279 -25. 657 1.00 33. 56 E c

ATOM 19340 CZ TYR E 202 36 289 -64. ,525 -24. 484 1.00 32. 96 E c

ATOM 19341 OH TYR E 202 34. 929 -64, ,695 -24. 536 1.00 35. 16 E 0

ATOM 19343 CE2 TYR E 202 36. 947 -64. .588 -23. ,281 1.00 31. ,54 E c

ATOM 19345 CD2 TYR E 202 38 321 -64, ,414 -23. ,245 1.00 31.54 E c

ATOM 19347 C TYR E 202 42 774 -64. ,836 -25. 140 1.00 35. 17 E c

ATOM 19348 O TYR E 202 43 451 -64. ,592 -24. 142 1.00 35. 22 E 0

ATOM 19350 N ILE E 203 43 260 -64, ,851 -26. 382 1.00 36. 40 E N

ATOM 19351 CA ILE E 203 44 669 -64. ,615 -26. 703 1.00 35. 88 E c

ATOM 19353 CB ILE E 203 45 334 -65. ,881 -27. 308 1.00 37. 23 E c

ATOM 19355 CGI ILE E 203 45. 228 -67. ,080 -26. 352 1.00 38. 30 E c

ATOM 19358 CDl ILE E 203 45. 356 -68. ,423 -27. 051 1.00 36. 62 E c

ATOM 19362 CG2 ILE E 203 46. 797 -65. ,604 -27. 653 1.00 37. 50 E c

ATOM 19366 C ILE E 203 44. 756 -63. ,508 -27. 747 1.00 34. 13 E c

ATOM 19367 O ILE E 203 44. 060 -63. ,564 -28. ,765 1.00 31. 41 E 0

ATOM 19369 N CYS E 204 45 596 -62. ,507 -27. ,502 1.00 35. 38 E N

ATOM 19370 CA CYS E 204 45 828 -61. ,453 -28. 492 1.00 36. 41 E c

ATOM 19372 CB CYS E 204 45 907 -60. ,067 -27. ,841 1.00 37. 36 E c

ATOM 19375 SG CYS E 204 47 309 -59, ,800 -26. 758 1.00 41. 10 E S

ATOM 19377 C CYS E 204 47. 100 -61. ,768 -29. 258 1.00 35. 87 E c

ATOM 19378 O CYS E 204 48. 111 -62. ,127 -28. 663 1.00 37. 21 E 0

ATOM 19380 N ASN E 205 47. 036 -61. ,636 -30. 578 1.00 37. 15 E N

ATOM 19381 CA ASN E 205 48. 155 -61. ,958 -31.456 1.00 36. 31 E c

ATOM 19383 CB ASN E 205 47. 671 -62. ,835 -32. 612 1.00 35. 45 E c

ATOM 19386 CG ASN E 205 46. 679 -63. ,900 -32. 158 1.00 36. 58 E c

ATOM 19387 OD1 ASN E 205 45 498 -63. ,853 -32. ,506 1.00 37. 24 E 0

ATOM 19388 ND2 ASN E 205 47 151 -64. ,844 -31.349 1.00 36. 66 E N

ATOM 19391 C ASN E 205 48 794 -60. ,674 -31. ,979 1.00 35. 69 E c

ATOM 19392 O ASN E 205 48 181 -59. ,954 -32. ,768 1.00 41. 33 E 0

ATOM 19394 N VAL E 206 50. 019 -60. ,396 -31. ,529 1.00 32. 20 E N

ATOM 19395 CA VAL E 206 50. 698 -59. ,132 -31. ,801 1.00 32. 81 E c

ATOM 19397 CB VAL E 206 51. 182 -58. ,502 -30. ,482 1.00 29. 12 E c

ATOM 19399 CGl VAL E 206 51. 866 -57. ,151 -30. ,729 1.00 25. 18 E c

ATOM 19403 CG2 VAL E 206 50. 008 -58. ,344 -29. ,518 1.00 30. 09 E c

ATOM 19407 C VAL E 206 51. 889 -59. ,324 -32. 743 1.00 34. 70 E c

ATOM 19408 O VAL E 206 52. 811 -60. ,079 -32. ,432 1.00 32. 02 E 0

ATOM 19410 N ASN E 207 51 870 -58. .648 -33. ,892 1.00 39. 36 E N

ATOM 19411 CA ASN E 207 52 994 -58. .721 -34. ,828 1.00 38. ,54 E c

ATOM 19413 CB ASN E 207 52 571 -59. .349 -36. ,168 1.00 43. ,66 E c

ATOM 19416 CG ASN E 207 53 758 -59. .985 -36. ,936 1.00 47. 20 E c

ATOM 19417 ODl ASN E 207 54 932 -59. ,672 -36. ,686 1.00 52. ,32 E 0

ATOM 19418 ND2 ASN E 207 53 443 -60. ,885 -37. ,871 1.00 46. 99 E N

ATOM 19421 C ASN E 207 53. 612 -57, ,351 -35. ,065 1.00 36. 96 E c

ATOM 19422 O ASN E 207 52. 915 -56, ,406 -35. ,405 1.00 38. 93 E 0

ATOM 19424 N HIS E 208 54. 926 -57, ,264 -34. ,877 1.00 32. 62 E N

ATOM 19425 CA HIS E 208 55. 706 -56. ,073 -35. ,192 1.00 34. 24 E c

ATOM 19427 CB HIS E 208 56. 221 -55, ,437 -33. ,893 1.00 28. 36 E c

ATOM 19430 CG HIS E 208 57 118 -54, .253 -34. ,089 1.00 25. ,55 E c

ATOM 19431 NDl HIS E 208 56 695 -53, .076 -34. ,669 1.00 28. ,06 E N

ATOM 19433 CEl HIS E 208 57 696 -52. ,215 -34. ,691 1.00 26. ,42 E c

ATOM 19435 NE2 HIS E 208 58 745 -52. .781 -34. 125 1.00 23. ,38 E N

ATOM 19437 CD2 HIS E 208 58 404 -54, .048 -33. 730 1.00 24. ,47 E c

ATOM 19439 C HIS E 208 56 843 -56. ,534 -36. 100 1.00 37. ,20 E c

ATOM 19440 O HIS E 208 57. 859 -57. ,026 -35. ,630 1.00 37. ,65 E 0

ATOM 19442 N LYS E 209 56. 651 -56. ,406 -37. ,411 1.00 40. ,81 E N cyno fD_Fab

ATOM 19443 CA LYS E 209 57. .598 -56. 970 -38. ,379 1.00 41. 45 E C

ATOM 19445 CB LYS E 209 57. ,055 -56. 892 -39. ,811 1.00 42. 60 E c

ATOM 19448 CG LYS E 209 55. ,892 -57. 819 -40. ,074 1.00 42. 27 E c

ATOM 19451 CD LYS E 209 55. ,529 -57. 850 -41. ,554 1.00 44. 38 E c

ATOM 19454 CE LYS E 209 54. ,060 -58. 239 -41.764 1.00 45. 63 E c

ATOM 19457 NZ LYS E 209 53. ,687 -58. 378 -43. ,199 1.00 45. 39 E N

ATOM 19461 C LYS E 209 58. ,986 -56. 343 -38. ,301 1.00 42. 10 E c

ATOM 19462 O LYS E 209 59. ,980 -57. 067 -38. ,316 1.00 43. 30 E 0

ATOM 19464 N PRO E 210 59. ,073 -55. 005 -38. ,182 1.00 42. 48 E N

ATOM 19465 CA PRO E 210 60. ,403 -54. 393 -38. ,119 1.00 42. 34 E c

ATOM 19467 CB PRO E 210 60. ,099 -52. 940 -37. ,754 1.00 42. 17 E c

ATOM 19470 CG PRO E 210 58. ,757 -52. 691 -38. ,325 1.00 42. 97 E c

ATOM 19473 CD PRO E 210 58. ,008 -53. 987 -38. ,123 1.00 43. 57 E c

ATOM 19476 C PRO E 210 61.368 -55. 020 -37. ,097 1.00 44. 50 E c

ATOM 19477 O PRO E 210 62. ,582 -54. 879 -37. ,249 1.00 47. 03 E 0

ATOM 19478 N SER E 211 60. ,843 -55. 705 -36. ,082 1.00 44. 02 E N

ATOM 19479 CA SER E 211 61. ,685 -56. 363 -35. ,086 1.00 43. 72 E c

ATOM 19481 CB SER E 211 61. ,436 -55. 738 -33. ,717 1.00 41. 80 E c

ATOM 19484 OG SER E 211 60. ,318 -56. 334 -33. ,084 1.00 40. 66 E 0

ATOM 19486 C SER E 211 61. 449 -57. 875 -35. ,015 1.00 44. 74 E c

ATOM 19487 O SER E 211 61. 874 -58. 526 -34. ,058 1.00 47. 19 E 0

ATOM 19489 N ASN E 212 60. 784 -58. 437 -36. ,022 1.00 46. 57 E N

ATOM 19490 CA ASN E 212 60. ,427 -59. 862 -36. ,022 1.00 48. 28 E c

ATOM 19492 CB ASN E 212 61. ,652 -60. 740 -36. ,313 1.00 51. 99 E c

ATOM 19495 CG ASN E 212 62. ,389 -60. 341 -37. ,578 1.00 54. 97 E c

ATOM 19496 ODl ASN E 212 61. ,913 -59. 526 -38. ,368 1.00 56. 53 E 0

ATOM 19497 ND2 ASN E 212 63. 568 -60. 924 -37. ,773 1.00 56. 67 E N

ATOM 19500 C ASN E 212 59. ,805 -60. 319 -34. ,698 1.00 49. 83 E c

ATOM 19501 O ASN E 212 60. ,056 -61. 441 -34. ,247 1.00 49. 62 E 0

ATOM 19503 N THR E 213 59. ,014 -59. 449 -34. 070 1.00 49. 07 E N

ATOM 19504 CA THR E 213 58. 333 -59. 785 -32. 826 1.00 46. 21 E c

ATOM 19506 CB THR E 213 58. 120 -58. 553 -31. 945 1.00 45. 85 E c

ATOM 19508 OGl THR E 213 59. ,391 -58. 017 -31.560 1.00 43. 91 E 0

ATOM 19510 CG2 THR E 213 57. ,322 -58. 915 -30. ,697 1.00 47. 53 E c

ATOM 19514 C THR E 213 56. ,988 -60. 399 -33. ,160 1.00 43. 49 E c

ATOM 19515 O THR E 213 56. ,162 -59. 768 -33. ,807 1.00 43. 98 E 0

ATOM 19517 N LYS E 214 56. ,788 -61. 641 -32. ,738 1.00 46. 87 E N

ATOM 19518 CA LYS E 214 55. ,516 -62. 336 -32. ,909 1.00 50. 09 E c

ATOM 19520 CB LYS E 214 55. ,626 -63. 423 -33. ,990 1.00 53. 30 E c

ATOM 19523 CG LYS E 214 54. ,905 -63. 065 -35. ,300 1.00 57. 32 E c

ATOM 19526 CD LYS E 214 55. ,438 -63. 810 -36. ,541 1.00 58. 48 E c

ATOM 19529 CE LYS E 214 55. ,735 -65. 291 -36. ,280 1.00 62. 04 E c

ATOM 19532 NZ LYS E 214 54. ,591 -66. 000 -35. ,638 1.00 64. 04 E N

ATOM 19536 C LYS E 214 55. ,100 -62. ,918 -31. ,566 1.00 48. 58 E c

ATOM 19537 O LYS E 214 55. ,484 -64. 036 -31.220 1.00 50. 07 E 0

ATOM 19539 N VAL E 215 54. ,320 -62. ,134 -30. ,820 1.00 47. 43 E N

ATOM 19540 CA VAL E 215 53. ,931 -62. 462 -29. ,447 1.00 45. 45 E c

ATOM 19542 CB VAL E 215 54. ,176 -61. 259 -28. ,507 1.00 42. 61 E c

ATOM 19544 CGI VAL E 215 53. ,807 -61. 603 -27. ,075 1.00 42. 46 E c

ATOM 19548 CG2 VAL E 215 55. ,628 -60. 808 -28. ,586 1.00 44. 38 E c

ATOM 19552 C VAL E 215 52. ,457 -62. 844 -29. ,371 1.00 43. 31 E c

ATOM 19553 O VAL E 215 51. ,614 -62. ,170 -29. .952 1.00 46. 91 E 0

ATOM 19555 N ASP E 216 52. ,158 -63. ,936 -28. .673 1.00 42. 98 E N

ATOM 19556 CA ASP E 216 50. ,788 -64. ,263 -28. .265 1.00 45. 24 E c

ATOM 19558 CB ASP E 216 50. 406 -65. ,684 -28. ,695 1.00 47. 29 E c

ATOM 19561 CG ASP E 216 50. 281 -65. ,837 -30. ,205 1.00 47. 73 E c

ATOM 19562 ODl ASP E 216 49. 978 -64. ,855 -30. ,913 1.00 45. 19 E 0

ATOM 19563 OD2 ASP E 216 50. ,479 -66. ,966 -30. ,686 1.00 50. 79 E 0

ATOM 19564 C ASP E 216 50. 676 -64. ,133 -26. ,737 1.00 46. 47 E c

ATOM 19565 O ASP E 216 51. ,598 -64. ,514 -26. ,007 1.00 45. 91 E 0

ATOM 19567 N LYS E 217 49. ,553 -63. ,596 -26, .259 1.00 44. 76 E N

ATOM 19568 CA LYS E 217 49. ,344 -63. ,390 -24, ,827 1.00 44. 01 E c

ATOM 19570 CB LYS E 217 49. ,581 -61. ,920 -24, .470 1.00 46. 16 E c

ATOM 19573 CG LYS E 217 49. ,649 -61.623 -22, .972 1.00 46. 48 E c

ATOM 19576 CD LYS E 217 51. ,030 -61. ,918 -22, ,407 1.00 47. 39 E c

ATOM 19579 CE LYS E 217 51.015 -61. ,894 -20, ,897 1.00 48. 11 E c

ATOM 19582 NZ LYS E 217 52. ,316 -61. 434 -20. .351 1.00 49. 85 E N

ATOM 19586 C LYS E 217 47. ,941 -63. ,811 -24. ,391 1.00 42. 42 E C cyno fD_Fab

ATOM 19587 O LYS E 217 46 955 -63 .219 -24. 808 1.00 41. ,36 E 0

ATOM 19589 N LYS E 218 47. 859 -64 .830 -23. 543 1.00 43. ,11 E N

ATOM 19590 CA LYS E 218 46. 585 -65 .212 -22. 944 1.00 43. ,66 E C

ATOM 19592 CB LYS E 218 46. 677 -66 .590 -22. 273 1.00 45. 68 E C

ATOM 19595 CG LYS E 218 45. 318 -67 .244 -21. 948 1.00 46. 25 E c

ATOM 19598 CD LYS E 218 45. 458 -68 .319 -20. 854 1.00 47. 40 E c

ATOM 19601 CE LYS E 218 44. 159 -69 .097 -20. 596 1.00 48. 51 E c

ATOM 19604 NZ LYS E 218 43 052 -68 .275 -20. 023 1.00 50. ,07 E N

ATOM 19608 C LYS E 218 46. 185 -64 .144 -21.924 1.00 42. 07 E c

ATOM 19609 O LYS E 218 47. 026 -63 .641 -21. 172 1.00 40. 49 E 0

ATOM 19611 N VAL E 219 44. 902 -63 .792 -21. 922 1.00 41. 33 E N

ATOM 19612 CA VAL E 219 44. 359 -62 .800 -21. 005 1.00 40. 40 E c

ATOM 19614 CB VAL E 219 43. 702 -61.630 -21. 776 1.00 37. ,59 E c

ATOM 19616 CGI VAL E 219 43. 182 -60 .579 -20. 814 1.00 36. 25 E c

ATOM 19620 CG2 VAL E 219 44. 694 -61 .021 -22. 767 1.00 36. 64 E c

ATOM 19624 C VAL E 219 43. 324 -63 .493 -20. 132 1.00 37. 88 E c

ATOM 19625 O VAL E 219 42. 375 -64 .079 -20. 643 1.00 33. 13 E 0

ATOM 19627 N GLU E 220 43. 512 -63 .438 -18. 818 1.00 41. ,61 E N

ATOM 19628 CA GLU E 220 42. 573 -64 .076 -17. 889 1.00 43. 58 E C

ATOM 19630 CB GLU E 220 42. 991 -65 .524 -17. 621 1.00 45. 82 E C

ATOM 19633 CG GLU E 220 44. 453 -65 .718 -17. 213 1.00 46. ,18 E c

ATOM 19636 CD GLU E 220 44. 917 -67 .163 -17. 346 1.00 46. 30 E c

ATOM 19637 OEl GLU E 220 44. 069 -68 .066 -17. 539 1.00 45. 96 E 0

ATOM 19638 OE2 GLU E 220 46. 140 -67 .396 -17. 262 1.00 47. 92 E 0

ATOM 19639 C GLU E 220 42. 454 -63 .294 -16. 589 1.00 41. 18 E c

ATOM 19640 O GLU E 220 43. 352 -62 .529 -16. 259 1.00 41.04 E 0

ATOM 19642 N PRO E 221 41. 342 -63 .477 -15. 848 1.00 41. 60 E N

ATOM 19643 CA PRO E 221 41. 107 -62 .660 -14. 644 1.00 45. 81 E c

ATOM 19645 CB PRO E 221 39. 768 -63 .189 -14. 109 1.00 42. ,70 E c

ATOM 19648 CG PRO E 221 39. 136 -63 .898 -15. 254 1.00 40. ,42 E c

ATOM 19651 CD PRO E 221 40. 253 -64 .446 -16. 072 1.00 39. ,34 E c

ATOM 19654 C PRO E 221 42. 197 -62 .803 -13. 577 1.00 47. ,97 E c

ATOM 19655 O PRO E 221 42. 730 -63 .895 -13. 398 1.00 50. ,30 E 0

ATOM 19656 N LYS E 222 42. 525 -61.709 -12. 887 1.00 52. 07 E N

ATOM 19657 CA LYS E 222 43. 501 -61 .745 -11. 779 1.00 53. ,07 E c

ATOM 19659 CB LYS E 222 44. 229 -60 .395 -11. 646 1.00 54. 66 E c

ATOM 19662 CG LYS E 222 45. 673 -60 .489 -11. 114 1.00 54. 68 E c

ATOM 19665 CD LYS E 222 46. 034 -59 .355 -10. 129 1.00 55. ,47 E c

ATOM 19668 CE LYS E 222 45. 851 -59 .798 -8. 660 1.00 56. ,24 E c

ATOM 19671 NZ LYS E 222 45. 990 -58 .691 -7. 662 1.00 55. ,37 E N

ATOM 19675 C LYS E 222 42. 779 -62 .069 -10. 468 1.00 53. ,36 E c

ATOM 19676 O LYS E 222 41. 676 -61 .569 -10. 236 1.00 54. ,04 E 0

ATOM 19678 N SER E 223 43. 399 -62 .895 -9. 619 1.00 54. ,19 E N

ATOM 19679 CA SER E 223 42. 852 -63 .227 -8. 290 1.00 54. ,01 E c

ATOM 19681 CB SER E 223 43. 310 -64 .621 -7. 856 1.00 52. ,50 E c

ATOM 19684 OG SER E 223 44. 719 -64 .737 -7. 936 1.00 50. ,56 E 0

ATOM 19686 C SER E 223 43. 264 -62 .191 -7. 236 1.00 54. ,58 E c

ATOM 19687 O SER E 223 43. 401 -62 .502 -6. 048 1.00 53. ,60 E 0

ATOM 19689 03 GOL G 1 15. 644 -12 .225 -31. 670 1.00 46. ,05 G 0

ATOM 19691 C3 GOL G 1 15. 907 -12 .056 -30. 280 1.00 47. ,89 G c

ATOM 19694 C2 GOL G 1 15. 938 -10 .576 -29. 870 1.00 46. ,30 G c

ATOM 19696 02 GOL G 1 16. 263 -9 .769 -30. 987 1.00 45. ,94 G 0

ATOM 19698 Cl GOL G 1 14. 585 -10 .095 -29. ,345 1.00 47. ,01 G c

ATOM 19701 01 GOL G 1 14. 210 -10 .684 -28. 122 1.00 44. ,95 G 0

ATOM 19703 03 GOL G 2 52. 092 -55 .065 -76. 953 1.00 19. ,73 G 0

ATOM 19705 C3 GOL G 2 52. 164 -55 .853 -78. 129 1.00 23. ,77 G c

ATOM 19708 C2 GOL G 2 51. 437 -55 .188 -79. ,290 1.00 21. ,18 G c

ATOM 19710 02 GOL G 2 51. 782 -55 .810 -80. 509 1.00 20. ,50 G 0

ATOM 19712 Cl GOL G 2 49. 926 -55 .318 -79. 068 1.00 20. ,44 G c

ATOM 19715 01 GOL G 2 49 239 -54 .191 -79. ,577 1.00 21. .26 G 0

ATOM 19717 03 GOL G 3 65 965 -55 .248 -63. ,330 1.00 57. ,18 G 0

ATOM 19719 C3 GOL G 3 66. 479 -55 .583 -62. ,056 1.00 57. ,77 G c

ATOM 19722 C2 GOL G 3 65 540 -55 .177 -60. ,920 1.00 55. .71 G c

ATOM 19724 02 GOL G 3 66. 160 -55 .508 -59. ,689 1.00 54. ,46 G 0

ATOM 19726 Cl GOL G 3 65. 158 -53 .692 -61. ,058 1.00 54. ,65 G c

ATOM 19729 01 GOL G 3 65. 149 -52 .979 -59. 837 1.00 52. ,71 G 0

ATOM 19731 03 GOL G 4 36. 529 -47 .221 -69. ,327 1.00 26. ,15 G 0

ATOM 19733 C3 GOL G 4 36. 387 -46 .616 -70. ,598 1.00 33. .10 G c cyn fD_Fab

ATOM 19736 C2 GOL G 4 36, .498 -45, .100 -70, .437 1.00 33, .87 G C

ATOM 19738 02 GOL G 4 37 .055 -44, .363 -71.524 1.00 31, .17 G 0

ATOM 19740 Cl GOL G 4 35 .146 -44, .489 -70 .154 1.00 26, .93 G C

ATOM 19743 01 GOL G 4 35. .402 -43, .118 -70 .211 1.00 17, .42 G 0

ATOM 19745 03 GOL G 5 53, .349 -53. .881 -94 .776 1.00 46, .57 G 0

ATOM 19747 C3 GOL G 5 52. .799 -52. ,620 -94, .458 1.00 50, .34 G C

ATOM 19750 C2 GOL G 5 53. .748 -51. .779 -93, .600 1.00 54, .72 G c

ATOM 19752 02 GOL G 5 54, .208 -52. ,527 -92, .487 1.00 53, .84 G 0

ATOM 19754 Cl GOL G 5 54. .936 -51. ,265 -94, .425 1.00 57, .21 G c

ATOM 19757 01 GOL G 5 55, .296 -49. ,962 -94, ,007 1.00 57, .71 G 0

ATOM 19759 03 GOL G 6 59. .790 -59. ,263 -84, ,436 1.00 47, .17 G 0

ATOM 19761 C3 GOL G 6 58. ,733 -60. ,153 -84, .149 1.00 47, .82 G c

ATOM 19764 C2 GOL G 6 57. .356 -59. ,672 -84, .624 1.00 47. .98 G c

ATOM 19766 02 GOL G 6 57, ,341 -58. ,284 -84, .898 1.00 47. ,56 G 0

ATOM 19768 Cl GOL G 6 56. .818 -60. ,437 -85, ,833 1.00 47. .02 G c

ATOM 19771 01 GOL G 6 55. ,485 -60. ,841 -85, .566 1.00 43. ,63 G 0

ATOM 19773 03 GOL G 7 53. .713 -35. ,146 -51, .931 1.00 40. .24 G 0

ATOM 19775 C3 GOL G 7 55. ,013 -34. ,581 -51. .814 1.00 46. ,78 G c

ATOM 19778 C2 GOL G 7 56. ,095 -35. ,427 -52. ,517 1.00 46. .26 G c

ATOM 19780 02 GOL G 7 56. ,863 -34. 629 -53. ,385 1.00 46. ,86 G 0

ATOM 19782 Cl GOL G 7 57. ,068 -36. ,089 -51.549 1.00 46. ,65 G c

ATOM 19785 01 GOL G 7 58. ,320 -35. ,443 -51. ,629 1.00 45. ,82 G 0

ATOM 19787 03 GOL G 8 -9. ,741 -10. 697 -55. ,319 1.00 25. .89 G 0

ATOM 19789 C3 GOL G 8 -9. ,353 -9. ,682 -54. ,405 1.00 25. ,72 G c

ATOM 19792 C2 GOL G 8 -10. ,493 -9. ,038 -53. ,584 1.00 20. ,92 G c

ATOM 19794 02 GOL G 8 -11.792 -9. ,137 -54. ,161 1.00 13. ,98 G 0

ATOM 19796 Cl GOL G 8 -10. ,559 -9. 578 -52. ,179 1.00 24. ,21 G c

ATOM 19799 01 GOL G 8 -9. ,297 -9. ,619 -51. ,562 1.00 22. ,66 G 0

ATOM 19801 03 GOL G 9 23. ,754 -54. 401 -57. ,185 1.00 39. ,94 G 0

ATOM 19803 C3 GOL G 9 24. ,397 -54. 111 -58. ,425 1.00 42. ,14 G c

ATOM 19806 C2 GOL G 9 25. ,919 -53. 952 -58. ,250 1.00 40. ,94 G c

ATOM 19808 02 GOL G 9 26. ,315 -54. 789 -57. ,201 1.00 36. ,99 G 0

ATOM 19810 Cl GOL G 9 26. ,755 -54. 318 -59. ,492 1.00 42. ,14 G c

ATOM 19813 01 GOL G 9 26. ,810 -53. 296 -60. ,476 1.00 38. ,73 G 0

ATOM 19815 03 GOL G 10 2. ,145 -23. 190 -61. ,347 1.00 51.92 G 0

ATOM 19817 C3 GOL G 10 3. ,547 -23. 378 -61.329 1.00 52. ,73 G c

ATOM 19820 C2 GOL G 10 3. 914 -24. 815 -60. ,947 1.00 52. ,10 G c

ATOM 19822 02 GOL G 10 3. 653 -25. 030 -59. ,570 1.00 49. 20 G 0

ATOM 19824 Cl GOL G 10 3. 182 -25. 828 -61. ,835 1.00 50. ,19 G c

ATOM 19827 01 GOL G 10 2. 024 -26. 336 -61.195 1.00 49. ,25 G 0

ATOM 19829 ZN ZN I 1 4. 956 -34. 114 -61. ,087 1.00 25. ,84 I ZN

ATOM 19830 ZN ZN I 2 48. 678 -30. 113 -66. ,514 1.00 20. ,35 I ZN

ATOM 19831 ZN ZN I 3 62. 846 -55. 911 -82. ,250 1.00 26. ,53 I ZN

ATOM 19832 ZN ZN I 4 38. 466 -12. 195 -34. ,686 1.00 61. ,87 I ZN

ATOM 19833 ZN ZN I 5 5. 806 -22. 193 -58. ,517 1.00 86. ,90 I ZN

ATOM 19834 ZN ZN I 6 1. 732 -11. 390 -76. 111 1.00133. ,94 I ZN

ATOM 19835 S S04 I 7 34. 756 -42. 392- 103. ,062 1.00 71. ,34 I S

ATOM 19836 01 S04 I 7 36. 066 -41.877- ^• 103. ,455 1.00 70. ,77 I 0

ATOM 19837 02 S04 I 7 33. 704 -41. 813- 103. ,894 1.00 71. 26 I 0

ATOM 19838 03 S04 I 7 34. 766 -43. 840- 103. ,200 1.00 73. ,57 I 0

ATOM 19839 04 S04 I 7 34. 476 -42. 081- ^• 101. 669 1.00 72. ,03 I 0

ATOM 19840 S S04 I 8 -18. 190 -24. 987 -80. ,132 1.00 43. ,16 I s

ATOM 19841 01 S04 I 8 -19. 063 -26. 015 -80. 685 1.00 47. ,41 I 0

ATOM 19842 02 S04 I 8 -17. 648 -25. 431 -78. 846 1.00 37. ,60 I 0

ATOM 19843 03 S04 I 8 -19. 000 -23. 813 -79. 851 1.00 41. 03 I 0

ATOM 19844 04 S04 I 8 -17. 134 -24. 708 -81.117 1.00 39. ,84 I 0

ATOM 19845 S S04 I 9 -5. 111 -15. 184 -69. 182 1.00 95. 52 I s

ATOM 19846 01 S04 I 9 -4. 436 -16. 135 -70. 071 1.00 95. 33 I 0

ATOM 19847 02 S04 I 9 -6. 254 -15. 845 -68. 563 1.00 95. 42 I 0

ATOM 19848 03 S04 I 9 -5. 608 -14. 044 -69. 951 1.00 93. 42 I 0

ATOM 19849 04 S04 I 9 -4. 184 -14. 723 -68. 146 1.00 93. 82 I 0

ATOM 19850 OWO WAT M 1 32. 447 -52. 213 -28. 369 1.00 13. 61 M 0

ATOM 19853 OWO WAT M 2 43. 667 -53. 676 -61. 408 1.00 17. 23 M 0

ATOM 19856 OWO WAT M 3 39. 955 -9. 300 -47. 861 1.00 41. 36 M 0

ATOM 19859 OWO WAT M 4 38. 518 -49. 564 -47. 346 1.00 18. 23 M 0

ATOM 19862 OWO WAT M 5 45. 855 -63. 208 -71. 780 1.00 21.22 M 0

ATOM 19865 OWO WAT M 6 2. 380 -10. 736 -71. 113 1.00 46. 11 M 0

ATOM 19868 OWO WAT M 7 36. 936 -53. 594 -60. 034 1.00 22. 76 M 0 cyno fD_Fab

ATOM 19871 OWO WAT M 8 39. ,684 -52. 094 -55. ,626 1.00 11. 11 M 0

ATOM 19874 OWO WAT M 9 57. ,718 -48. 274 -40. ,882 1.00 21. 01 M 0

ATOM 19877 OWO WAT M 10 59. ,874 -52. 890 -48. ,581 1.00 21. 89 M 0

ATOM 19880 OWO WAT M 11 40. ,931 -52. 821 -53. ,220 1.00 18. 56 M 0

ATOM 19883 OWO WAT M 12 28. 694 -46. 022 -38. ,596 1.00 24. 32 M 0

ATOM 19886 OWO WAT M 13 36. ,638 -53. 121 -57. ,166 1.00 26. 22 M 0

ATOM 19889 OWO WAT M 14 36. ,706 -51. 271 -74. ,659 1.00 26. 60 M 0

ATOM 19892 OWO WAT M 15 22. ,655 -43. 522 -55. ,307 1.00 17. 11 M 0

ATOM 19895 OWO WAT M 16 32. 973 -53. 562 -35. ,803 1.00 30. 84 M 0

ATOM 19898 OWO WAT M 17 35. 322 -43. 959 -78. ,938 1.00 35. 02 M 0

ATOM 19901 OWO WAT M 18 32. 881 -13. 459 -35. ,424 1.00 29. 50 M 0

ATOM 19904 OWO WAT M 19 30. 077 -49. 664 -47. ,842 1.00 24. 59 M 0

ATOM 19907 OWO WAT M 20 7. ,391 -28. 329 -62. ,497 1.00 45. 79 M 0

ATOM 19910 OWO WAT M 21 32. 317 -38. 328 -88. ,292 1.00 33. 98 M 0

ATOM 19913 OWO WAT M 22 6. 907 -40. 387 -50. ,076 1.00 27. 28 M 0

ATOM 19916 OWO WAT M 23 -18. 929 -21. 721 -58. ,173 1.00 38. 25 M 0

ATOM 19919 OWO WAT M 24 23. ,138 -52. 138 -42. ,463 1.00 30. ,67 M 0

ATOM 19922 OWO WAT M 25 42. 662 -55. 039 -53. ,944 1.00 16. 46 M 0

ATOM 19925 owo WAT M 26 41. ,555 -41. 997 -46. ,029 1.00 32. 15 M 0

ATOM 19928 OWO WAT M 27 54. ,754 -66. 740 -90. ,878 1.00 40. 45 M 0

ATOM 19931 owo WAT M 28 21. 396 -41. 984 -37. ,940 1.00 17. 00 M 0

ATOM 19934 OWO WAT M 29 42. 492 -72. 023 -81. ,488 1.00 34. 62 M 0

ATOM 19937 OWO WAT M 30 30. 534 -39. 421 -60. ,977 1.00 16. 31 M 0

ATOM 19940 OWO WAT M 31 37. 599 -40. 892 -34. ,338 1.00 33. 76 M G

ATOM 19943 OWO WAT M 32 49. ,371 -62. 274 -85. ,500 1.00 35. ,83 M 0

ATOM 19946 OWO WAT M 33 32. ,108 -13. 135 -33. ,034 1.00 21. 74 M 0

ATOM 19949 OWO WAT M 34 -7. ,950 0. 970 -56. ,407 1.00 23. 19 M 0

ATOM 19952 OWO WAT M 35 24. ,860 -10. 430 -41. ,359 1.00 45. 73 M 0

ATOM 19955 OWO WAT M 36 -19. 332 -13. 591 -49. ,789 1.00 28. 92 M 0

ATOM 19958 OWO WAT M 37 68. 844 -46. 749 -43. ,240 1.00 27. 78 M 0

ATOM 19961 OWO WAT M 38 -22. 526 -12. 433 -57. ,418 1.00 35. 52 M 0

ATOM 19964 OWO WAT M 39 34. 045 -48. 536 -65. ,990 1.00 9. 87 M 0

ATOM 19967 OWO WAT M 40 21. 650 -50. 754 -51. ,056 1.00 28. 21 M 0

ATOM 19970 OWO WAT M 41 21. ,813 -10. 200 -51. ,201 1.00 36. 44 M 0

ATOM 19973 OWO WAT M 42 33. ,683 -46. 431 -78. ,260 1.00 28. 04 M 0

ATOM 19976 OWO WAT M 43 47. ,157 -43. 077 -43. ,120 1.00 28. 78 M 0

ATOM 19979 OWO WAT M 44 31. ,952 -51.688 -30. ,144 1.00 18. 93 M 0

ATOM 19982 owo WAT M 45 22. ,774 -53. 965 -53. ,796 1.00 23. 46 M 0

ATOM 19985 OWO WAT M 46 45. 605 -54. 549 -36. ,052 1.00 26. 10 M 0

ATOM 19988 OWO WAT M 47 26. 524 -45. 407 -61. ,123 1.00 20. 13 M 0

ATOM 19991 OWO WAT M 48 32. 651 -47. 885 -30. ,913 1.00 29. 90 M 0

ATOM 19994 OWO WAT M 49 34. 226 -41. 327 -41. ,389 1.00 33. 57 M 0

ATOM 19997 OWO WAT M 50 33. ,360 0. 714 -38. .214 1.00 46. 09 M 0

ATOM 20000 owo WAT M 51 54. ,150 -52. 248 -44. .063 1.00 28. 07 M 0

ATOM 20003 OWO WAT M 52 31.109 -45. 088 -85. ,518 1.00 39. ,75 M 0

ATOM 20006 owo WAT M 53 -29. 772 -12. 663 -85. .086 1.00 28. 32 M 0

ATOM 20009 OWO WAT M 54 37. 723 -10. 746 -15, ,154 1.00 37. 06 M 0

ATOM 20012 OWO WAT M 55 35. ,779 -51. 578 -14. ,654 1.00 29. 25 M 0

ATOM 20015 OWO WAT M 56 -7. 296 6. 351 -63. ,298 1.00 26. 61 M 0

ATOM 20018 OWO WAT M 57 33. 290 -40. 774 -38. ,512 1.00 26. 57 M 0

ATOM 20021 OWO WAT M 58 34. 928 -9. 246 -35. ,370 1.00 35. ,96 M 0

ATOM 20024 OWO WAT M 59 34. ,964 -50. 093 -37, .158 1.00 32. ,14 M 0

ATOM 20027 owo WAT M 60 42. ,674 -31. 549 -83, .873 1.00 29. ,16 M 0

ATOM 20030 OWO WAT M 61 -12. ,422 -22. 493 -60, .061 1.00 32. ,20 M 0

ATOM 20033 OWO WAT M 62 45. 399 -55. 935 -50, .842 1.00 31. 92 M 0

ATOM 20036 OWO WAT M 63 32. ,518 -48. 393 -42, .112 1.00 37. ,08 M 0

ATOM 20039 OWO WAT M 64 30. ,888 -51. 096 -50. .144 1.00 29. ,52 M 0

ATOM 20042 owo WAT M 65 6. ,751 -0. 391 -34. .223 1.00 49. ,91 M 0

ATOM 20045 OWO WAT M 66 -8. ,546 -29. 662 -68. ,949 1.00 9. 99 M 0

ATOM 20048 OWO WAT M 67 20. ,864 -50. 221 -48. ,762 1.00 28. 44 M 0

ATOM 20051 owo WAT M 68 41. ,096 -60. 076 -63, .006 1.00 25. ,20 M 0

ATOM 20054 OWO WAT M 69 54. ,407 -54. 801 -38, .178 1.00 33. ,00 M 0

ATOM 20057 OWO WAT M 70 43. ,404 -48. 198 -84, .642 1.00 20. ,80 M 0

ATOM 20060 OWO WAT M 71 22. ,918 -47. 808 -58, .133 1.00 23. ,93 M 0

ATOM 20063 OWO WAT M 72 50. ,250 -53. 312 -17, .607 1.00 31. ,63 M 0

ATOM 20066 OWO WAT M 73 -29. ,746 -12. 309 -69, .229 1.00 32. ,99 M 0

ATOM 20069 owo WAT M 74 21. ,206 -9. 173 -47, .551 1.00 46. ,07 M 0

ATOM 20072 OWO WAT M 75 -11. ,643 -28. 378 -66, .482 1.00 21. ,29 M 0 cyno fD_Fab

ATOM 20075 OWO WAT M 76 -12. ,034 11. 848 -65. Oil 1. 00 32. 38 M 0

ATOM 20078 OWO WAT M 77 26. .610 -49. 497 -63. 568 1. 00 20. 61 M 0

ATOM 20081 OWO WAT M 78 49. ,568 -21. 186 -11. ,757 1. 00 54. 01 M 0

ATOM 20084 OWO WAT M 79 50. ,555 -59. 882 -14. ,706 1. 00 30. 62 M 0

ATOM 20087 OWO WAT M 80 36. ,584 0. 126 -35. 316 1. 00 42. 91 M 0

ATOM 20090 OWO WAT M 81 -31. ,498 -7. 402 -85. ,582 1. 00 34. 72 M 0

ATOM 20093 OWO WAT M 82 37. ,292 -55. 311 -17. ,164 1. 00 32. 25 M 0

ATOM 20096 OWO WAT M 83 41. ,294 -62. 543 -59. 528 1. 00 21. 78 M 0

ATOM 20099 OWO WAT M 84 -7. ,151 -19. 370 -35. 262 1. 00 41. 50 M 0

ATOM 20102 OWO WAT M 85 35. ,221 -10. 243 -49. 200 1. 00 31. 10 M 0

ATOM 20105 OWO WAT M 86 42. ,355 -56. 137 -51. 393 1. 00 28. 48 M 0

ATOM 20108 OWO WAT M 87 43. ,146 -60. ,656 -64. ,450 1. 00 22. 78 M 0

ATOM 20111 owo WAT M 88 -20. ,147 -7. 515 -56. ,101 1. 00 26. 77 M 0

ATOM 20114 OWO WAT M 89 61.876 -56. ,102 -45. ,752 1. 00 28. 56 M 0

ATOM 20117 OWO WAT M 90 38. ,863 9. 044 -26. ,507 1. 00 44. 62 M 0

ATOM 20120 OWO WAT M 91 37. ,455 -10. 303 -36. 122 1. 00 42. 93 M 0

ATOM 20123 OWO WAT M 92 -22. ,756 -22. 193 -59. 900 1. 00 45. 91 M 0

ATOM 20126 OWO WAT M 93 31.176 -39. 939 -65. 985 1. 00 34. 61 M 0

ATOM 20129 OWO WAT M 94 41. ,436 -72. 033 -79. 172 1. 00 42. 71 M 0

ATOM 20132 OWO WAT M 95 58. ,508 -63. 071 -36. 039 1. 00 56. 23 M 0

ATOM 20135 OWO WAT M 96 -25. ,811 -18. 278 -59. ,536 1. 00 32. 21 M 0

ATOM 20138 OWO WAT M 97 39. ,310 -52. ,834 -48. ,801 1. 00 27. 28 M 0

ATOM 20141 OWO WAT M 98 33. ,363 -62. 846 -32. ,990 1. 00 36. 31 M 0

ATOM 20144 OWO WAT M 99 32. ,538 -9. 531 -49. 020 1. 00 38. 46 M 0

ATOM 20147 OWO WAT M 100 35. ,980 -42. 881 -74. ,344 1. 00 47. 87 M 0

ATOM 20150 OWO WAT M 101 37. 539 -50. 141 -33. ,519 1. 00 30. 75 M 0

ATOM 20153 OWO WAT M 102 3. 492 -22. 105 -57. 950 1. 00 41. 77 M 0

ATOM 20156 OWO WAT M 103 45. ,725 -46. 595 -26. 678 1. 00 29. 39 M 0

ATOM 20159 owo WAT M 104 -6. ,322 -20. 181 -47. 556 1. 00 27. 90 M 0

ATOM 20162 OWO WAT M 105 61. ,208 -56. ,929 -86. ,317 1. 00 38. 81 M 0

ATOM 20165 OWO WAT M 106 66. ,676 -45. ,522 -38. 489 1. 00 31. 17 M 0

ATOM 20168 OWO WAT M 107 44. ,669 -46. 424 -43. 364 1. 00 32. 00 M 0

ATOM 20171 OWO WAT M 108 46. ,540 -22. 002 -0. 088 1. 00 35. 73 M 0

ATOM 20174 OWO WAT M 109 28. ,585 -41.210 -67. 573 1. 00 24. 60 M 0

ATOM 20177 OWO WAT M 110 36. ,156 3. 773 -32. 069 1. 00 37. 12 M 0

ATOM 20180 OWO WAT M 111 -19. ,831 -12. 315 -68. 033 1. 00 28. 68 M 0

ATOM 20183 OWO WAT M 112 35. ,385 -40. 254 -74. ,683 1. 00 24. 65 M 0

ATOM 20186 owo WAT M 113 23. ,186 -44. ,471 -23. 295 1. 00 39. 07 M 0

ATOM 20189 OWO WAT M 114 35. ,755 -53. ,155 -75. ,603 1. 00 32. 92 M 0

ATOM 20192 OWO WAT M 115 54. ,918 -65. ,782 -93. ,310 1. 00 36. 42 M 0

ATOM 20195 OWO WAT M 116 46. ,997 -62. ,185 -18. ,320 1. 00 38. 84 M 0

ATOM 20198 OWO WAT M 117 41. ,055 -42. 790 -34. ,877 1. 00 29. 51 M 0

ATOM 20201 OWO WAT M 118 42. ,140 -37. 827 -45. ,166 1. 00 29. 44 M 0

ATOM 20204 OWO WAT M 119 34. ,426 -48. 186 -39. ,707 1. 00 32. 56 M 0

ATOM 20207 OWO WAT M 120 36. ,915 -42. ,688 -42. ,160 1. 00 32. 98 M 0

ATOM 20210 OWO WAT M 121 28. ,304 -12. ,554 -57. ,767 1. 00 39. 16 M 0

ATOM 20213 OWO WAT M 122 36. ,595 -50. ,463 -48. ,265 1. 00 32. 34 M 0

ATOM 20216 OWO WAT M 123 -22. ,469 -10. ,062 -56. ,334 1. 00 22. 95 M 0

ATOM 20219 OWO WAT M 124 34. ,430 -48. ,553 -76. ,973 1. 00 33. 24 M 0

ATOM 20222 OWO WAT M 125 -26. ,127 -4. ,667 -70. .808 1. 00 33. 23 M 0

ATOM 20225 OWO WAT M 126 -27. ,828 -8. ,374 -59. ,067 1. 00 19. 84 M 0

ATOM 20228 OWO WAT M 127 -31. ,963 -9. ,683 -82. ,802 1. 00 36. 00 M 0

ATOM 20231 OWO WAT M 128 -32. ,011 -6. ,514 -87. ,893 1. 00 40. 12 M 0

ATOM 20234 OWO WAT M 129 -29. ,458 -6. ,576 -81.340 1. 00 36. 57 M 0

ATOM 20237 OWO WAT M 130 40. ,919 -52. ,898 -6. ,066 1. 00 42. 35 M 0

ATOM 20240 OWO WAT M 131 -16. .430 10. ,124 -69. ,881 1. 00 46. 95 M 0

ATOM 20243 OWO WAT M 132 51.233 -23. ,823 -13. ,332 1. 00 38. 53 M 0

ATOM 20246 OWO WAT M 133 47. ,215 -51. ,600 -17. ,510 1. 00 34. 97 M 0

ATOM 20249 OWO WAT M 134 52, ,367 -55. ,193 -40. ,633 1. 00 39. 71 M 0

ATOM 20252 OWO WAT M 135 43. ,584 -63. ,498 -64, ,027 1. 00 29. 82 M 0

ATOM 20255 owo WAT M 136 26. ,143 -41. ,264 -66. ,488 1. 00 26. 86 M 0

ATOM 20258 OWO WAT M 137 33. ,624 -43. ,934 -74. ,827 1. 00 28. 33 M 0

ATOM 20261 OWO WAT M 138 -17, ,182 -26. 897 -74. ,243 1. 00 38. 04 M 0

ATOM 20264 owo WAT M 139 62. ,509 -44. ,270 -30. .655 1. 00 40. 08 M 0

ATOM 20267 owo WAT M 140 24. .602 -52. ,514 -61. .486 1. 00 36. 11 M 0

ATOM 20270 OWO WAT M 141 -20. ,563 -23. ,058 -66. ,219 1. 00 37. 41 M 0

ATOM 20273 owo WAT M 142 -5. ,083 0. ,041 -48. ,826 1. 00 37. 36 M 0

ATOM 20276 owo WAT M 143 24. ,927 -47, ,306 -59. ,764 1. 00 34. 56 M 0 cyno fD_Fab

ATOM 20279 OWO WAT M 144 40 439 -60. 198 -59 664 1. 00 33. 11 M 0

ATOM 20282 OWO WAT M 145 49 715 -69. 990 -82 724 1. 00 27. 68 M 0

ATOM 20285 OWO WAT M 146 36 089 -50. 651 -69 304 1. 00 31. 88 M 0

ATOM 20288 OWO WAT M 147 36 824 -7. 928 -37 568 1. 00 41. 97 M 0

ATOM 20291 OWO WAT M 148 59 311 -40. 442 -38 365 1. 00 32. 43 M 0

ATOM 20294 OWO WAT M 149 -4 834 5 . 888 -63 790 1. 00 33. 48 M 0

ATOM 20297 OWO WAT M 150 29 159 -43 . 652 -84 009 1. 00 37. 06 M 0

ATOM 20300 OWO WAT M 151 63 527 -57. 757 -81 797 1. 00 33 . 87 M 0

ATOM 20303 OWO WAT M 152 44 009 -30. 045 -29 453 1. 00 39. 31 M 0

ATOM 20306 OWO WAT M 153 -17 518 -3. 802 -55 802 1. 00 29. 57 M 0

ATOM 20309 OWO WAT M 154 34 554 -47. 423 -32 559 1. 00 36 00 M 0

ATOM 20312 owo WAT M 155 39 401 -53. 923 -51 617 1. 00 24 94 M 0

ATOM 20315 OWO WAT M 156 21 226 -14. 524 -42 265 1. 00 12. 93 M 0

ATOM 20318 owo WAT M 157 50 087 -49. 822 -36 029 1. 00 34. 29 M 0

ATOM 20321 OWO WAT M 158 30 118 -53 . 063 -32 998 1. 00 39. 47 M 0

ATOM 20324 owo WAT M 159 17 856 -47. 458 -43 654 1. 00 34. 39 M 0

ATOM 20327 OWO WAT M 160 23 169 -52 . 701 -44 907 1. 00 35. 16 M 0

ATOM 20330 OWO WAT M 161 26 409 -55 . 938 -18 337 1. 00 38. 68 M 0

ATOM 20333 OWO WAT M 162 21 920 -14. 170 -44 563 1. 00 25. 88 M 0

ATOM 20336 owo WAT M 163 55 700 -41. 092 -11 775 1. 00 33. 81 M 0

ATOM 20339 OWO WAT M 164 -18 275 5. 273 -69 261 1. 00 44. 92 M 0

ATOM 20342 OWO WAT M 165 57 511 -63. 012 -89 586 1. 00 42 41 M 0

ATOM 20345 OWO WAT M 166 53 286 -18. 009 -18 268 1. 00 54 86 M 0

ATOM 20348 OWO WAT M 167 40 204 -43 . 748 -43 549 1. 00 34 83 M 0

ATOM 20351 OWO WAT M 168 21 440 -45 . 343 -59 672 1. 00 41 72 M 0

ATOM 20354 owo WAT M 169 5 190 -19. 719 -62 708 1. 00 32 23 M 0

ATOM 20357 OWO WAT M 170 -23 211 5 . 742 -73 923 1. 00 33. 19 M 0

ATOM 20360 owo WAT M 171 67 844 -48. 104 -40 213 1. 00 34. 45 M 0

ATOM 20363 OWO WAT M 172 35 502 -45 . 595 -41 516 1. 00 37. 75 M 0

ATOM 20366 owo WAT M 173 -7 750 -28. 255 -81 808 1. 00 42. 45 M 0

ATOM 20369 OWO WAT M 174 39 841 -63. 746 -20 076 1. 00 38. 63 M 0

ATOM 20372 OWO WAT M 175 48 424 -47. 505 -35 290 1. 00 41. 09 M 0

ATOM 20375 OWO WAT M 176 16 343 1. 414 -41 239 1. 00 40. 93 M 0

ATOM 20378 OWO WAT M 177 16 584 -40. 599 -42 471 1. 00 40 01 M 0

ATOM 20381 owo WAT M 178 46 067 -29. 464 -85 047 1. 00 42 90 M 0

ATOM 20384 OWO WAT M 179 61 119 -50. 705 -22 849 1. 00 34 07 M 0

ATOM 20387 owo WAT M 180 39 823 -76. 724 -97 320 1. 00 43 44 M 0

ATOM 20390 OWO WAT M 181 -23 258 -11. 404 -62 617 1. 00 23 42 M 0

ATOM 20393 owo WAT M 182 15 909 -43 . 915 -46 581 1. 00 27 40 M 0

ATOM 20396 OWO WAT M 183 65 971 -57. 589 -85 815 1. 00 17 42 M 0

ATOM 20399 owo WAT M 184 47 083 -73 . 092 -93 529 1. 00 35 45 M 0

ATOM 20402 OWO WAT M 185 42 156 -60. 698 -55 738 1. 00 32 53 M 0

ATOM 20405 OWO WAT M 186 38 525 -44. 405 -81 077 1. 00 24 51 M 0

ATOM 20408 OWO WAT M 187 66 053 -57. 959 -83 343 1. 00 19 90 M 0

ATOM 20411 OWO WAT M 188 -31 968 -6. 914 -83 125 1. 00 40 25 M 0

ATOM 20414 OWO WAT M 189 47 635 -44 665 -35 833 1. 00 23 17 M 0

ATOM 20417 OWO WAT M 190 32 874 -53 413 -32 102 1. 00 40 82 M 0

ATOM 20420 OWO WAT M 191 -20 696 -21 995 -64 037 1. 00 25 74 M 0

ATOM 20423 OWO WAT M 192 -33 453 -9. 233 -88 263 1. 00 26 61 M 0

ATOM 20426 OWO WAT M 193 44 551 -54. 068 -8 211 1. 00 43 39 M 0

ATOM 20429 OWO WAT M 194 28 538 -16. 303 -32 375 1. 00 39 17 M 0

ATOM 20432 owo WAT M 195 42 968 -28. 457 -31 909 1. 00 43 02 M 0

ATOM 20435 OWO WAT M 196 -36 022 -2. 141 -88 086 1. 00 47 69 M 0

ATOM 20438 OWO WAT M 197 67 527 -48. 415 -52 554 1. 00 72 95 M 0

ATOM 20441 OWO WAT M 198 -25 Oil -15. 863 -56 526 1. 00 27 60 M 0

ATOM 20444 OWO WAT M 199 53 618 -19. 047 -11 793 1. 00 54 88 M 0

ATOM 20447 OWO WAT M 200 38 680 -44 165 -67 257 1. 00 13 32 M 0

ATOM 20450 OWO WAT M 201 35 342 -49 879 -34 505 1. 00 32 46 M 0

ATOM 20453 OWO WAT M 202 32 699 -53 194 -63 584 1. 00 39 46 M 0

ATOM 20456 owo WAT M 203 62 230 -60 015 -81 080 1. 00 39 19 M 0

ATOM 20459 OWO WAT M 204 42 609 -54 150 -46 852 1. 00 31 03 M 0

ATOM 20462 OWO WAT M 205 57 421 -58 795 -79 913 1. 00 24 40 M 0

ATOM 20465 owo WAT M 206 -1 781 -28 928 -79 505 1. 00 30 44 M 0

ATOM 20468 OWO WAT M 207 -16 069 -23 873 -71 249 1. 00 24 55 M 0

ATOM 20471 OWO WAT M 208 33 233 -13 718 -54 796 1. 00 39 03 M 0

ATOM 20474 OWO WAT M 209 0 038 -27 618 -29 119 1. 00 37 71 M 0

ATOM 20477 OWO WAT M 210 6 611 -9. 334 -26 819 1. 00 33 12 M 0

ATOM 20480 OWO WAT M 211 -33 477 -3. 575 -76 066 1. 00 54 07 M 0 cyno fD_Fab

ATOM 20483 OWO WAT M 212 44. 969 -43. 820 -43. 980 1. 00 42. 81 M 0

ATOM 20486 OWO WAT M 213 48. Oil -53. 687 -18. ,743 1. 00 51. ,34 M 0

ATOM 20489 OWO WAT M 214 34. ,877 -1. 161 -36. 603 1. 00 44. ,40 M 0

ATOM 20492 OWO WAT M 215 27. ,256 -10. 720 -56. 343 1. 00 44. 52 M 0

ATOM 20495 OWO WAT M 216 -14. ,928 -22. 932 -59. 120 1. 00 38. 92 M 0

ATOM 20498 OWO WAT M 217 3. ,318 -36. 154 -47. 180 1. 00 29. 93 M 0

ATOM 20501 owo WAT M 218 41.634 1. 468 -6. 527 1. 00 46. 18 M 0

ATOM 20504 OWO WAT M 219 41. ,474 -40. 742 -6. 705 1. 00 37. 58 M 0

ATOM 20507 OWO WAT M 220 46. ,166 -25. 386 3. 099 1. 00 47. 88 M 0

ATOM 20510 OWO WAT M 221 15. ,110 -44. 667 -43. ,353 1. 00 35. 80 M 0

ATOM 20513 owo WAT M 222 26. ,651 -45. 961 -90. 553 1. 00 45. 01 M 0

ATOM 20516 OWO WAT M 223 42. ,138 -30. 682 -78. 964 1. 00 38. ,34 M 0

ATOM 20519 OWO WAT M 224 18. ,110 -40. 906 -51. 600 1. 00 39. ,80 M 0

ATOM 20522 OWO WAT M 225 37. ,421 -53. 752 -34. 765 1. 00 28. 13 M 0

ATOM 20525 OWO WAT M 226 24. ,010 -13. 937 -48. 939 1. 00 33. 66 M 0

ATOM 20528 owo WAT M 227 -10. ,788 -1. 598 -51. 705 1. 00 52. 26 M 0

ATOM 20531 OWO WAT M 228 -9. ,342 -0. 548 -53. 275 1. 00 35. 04 M 0

ATOM 20534 owo WAT M 229 36. ,740 -0. 153 -7. 777 1. 00 51. 87 M 0

ATOM 20537 OWO WAT M 230 -32. ,194 -7. 600 -90. 379 1. 00 41. ,64 M 0

ATOM 20540 owo WAT M 231 -26. ,129 4. 021 -80. 611 1. 00 33. ,87 M 0

ATOM 20543 OWO WAT M 232 38. ,422 -27. 110 -22. 773 1. 00 32. 00 M 0

ATOM 20546 owo WAT M 233 40. ,442 -51. 632- •112. 574 1. 00 53. ,56 M 0

ATOM 20549 OWO WAT M 234 47. ,043 -45. 923 -28. 488 1. 00 43. 38 M 0

ATOM 20552 owo WAT M 235 45. ,425 -71. 690 -21. 363 1. 00 55. 91 M 0

ATOM 20555 OWO WAT M 236 39. 537 -40. 377 -40. 802 1. 00 32. 06 M 0

ATOM 20558 OWO WAT M 237 48. ,727 -43. 288 -94. 057 1. 00 31. ,30 M 0

ATOM 20561 OWO WAT M 238 50. 398 -49. 249- -106. 653 1. 00 56. ,65 M 0

ATOM 20564 OWO WAT M 239 44. ,815 -55. 207 -15. 507 1. 00 36. ,92 M 0

ATOM 20567 OWO WAT M 240 44. ,862 -40. 975 -44. 004 1. 00 34. ,57 M 0

ATOM 20570 OWO WAT M 241 20. ,468 -43. 491 -34. 014 1. 00 33. 16 M 0

ATOM 20573 OWO WAT M 242 39. 745 -46. 962 -35. 925 1. 00 38. 42 M 0

ATOM 20576 OWO WAT M 243 40. 728 -5. 740 -34. 599 1. 00 60. 57 M 0

ATOM 20579 owo WAT M 244 58. 026 -63. 703 -10. 983 1. 00 44. 36 M 0

ATOM 20582 OWO WAT M 245 20. ,661 -12. 785 -32. ,651 1. 00 41. ,75 M 0

ATOM 20585 OWO WAT M 246 36. ,631 -52. 972 -71. ,532 1. 00 37. ,47 M 0

ATOM 20588 OWO WAT M 247 16. ,218 -40. ,288 -44. 656 1. 00 38. 75 M 0

ATOM 20591 OWO WAT M 248 -20. ,443 -15. 570 -50. 453 1. 00 37. ,27 M 0

ATOM 20594 OWO WAT M 249 -26. ,712 -14. 177 -67. 370 1. 00 33. 35 M 0

ATOM 20597 OWO WAT M 250 26. ,801 -48. 130 -65. 969 1. 00 29. 89 M 0

ATOM 20600 OWO WAT M 251 23. 983 -45. 680 -36. 859 1. 00 31.19 M 0

ATOM 20603 OWO WAT M 252 44. 471 -47. 180 3. 932 1. 00 58. 60 M 0

ATOM 20606 OWO WAT M 253 67. ,762 -55. ,189 -83. ,670 1. 00 18. ,58 M 0

ATOM 20609 owo WAT M 254 44. ,174 -22. 799 4. ,057 1. 00 48. ,79 M 0

ATOM 20612 OWO WAT M 255 65. ,520 -52. 434 -47. ,248 1. 00 37. 60 M 0

ATOM 20615 owo WAT M 256 -37. ,423 -2. 441 -84. ,852 1. 00 44. ,25 M 0

ATOM 20618 OWO WAT M 257 -22. ,530 -14. 860 -54. ,710 1. 00 22. ,70 M 0

ATOM 20621 owo WAT M 258 51. ,441 -21. 275 -13. ,718 1. 00 55. 28 M 0

ATOM 20624 OWO WAT M 259 -12. ,665 -23. 438 -57. ,688 1. 00 50. ,48 M 0

ATOM 20627 OWO WAT M 260 -25. ,351 -10. 633 -78. 176 1. 00 17. ,97 M 0

ATOM 20630 OWO WAT M 261 -35. ,720 -2. ,329 -75. ,507 1. 00 27. ,77 M 0

ATOM 20633 OWO WAT M 262 -28. ,699 -20. ,359 -76. ,813 1. 00 26. ,38 M 0

ATOM 20636 OWO WAT M 263 59. ,905 -58. ,747 -81. 014 1. 00 18. 26 M 0

ATOM 20639 OWO WAT M 264 68. ,534 -45. ,248 -54. ,627 1. 00 98. ,21 M 0

ATOM 20642 owo WAT M 265 66. ,436 -41. ,158 -57. 812 1. 00 33. ,12 M 0

ATOM 20645 OWO WAT M 266 39. ,448 -61.439 -80. 879 1. 00 42. ,76 M 0

ATOM 20648 OWO WAT M 267 -19. ,669 -9. 417 -55. ,734 1. 00238. ,71 M 0

ATOM 20651 OWO WAT M 268 38. ,386 -48. 043 -37. ,593 1. 00 31. ,76 M 0

ATOM 20654 OWO WAT M 269 53. ,358 -20. ,178 -15. ,234 1. 00 52. ,57 M 0

ATOM 20657 OWO WAT M 270 -22. ,519 -12. 929 -60. ,286 1. 00 23. ,47 M 0

ATOM 20660 OWO WAT M 271 29. 993 -11. 889 -53. ,915 1. 00 35. ,87 M 0

ATOM 20663 OWO WAT M 272 -26. ,961 -4. 297 -68. ,346 1. 00 23. ,34 M 0

ATOM 20666 owo WAT M 273 35. ,728 -51. 272 -85. ,479 1. 00 29. ,40 M 0

ATOM 20669 OWO WAT M 274 51. ,082 -60. 955 -17. ,074 1. 00 39. ,07 M 0

ATOM 20672 OWO WAT M 275 41. ,608 -66. ,431 -21. ,460 1. 00 41.24 M 0

ATOM 20675 OWO WAT M 276 41. ,981 11. 396 -28. ,323 1. 00 49. ,20 M 0

ATOM 20678 OWO WAT M 277 39. ,938 -36. ,047 -21. ,926 1. 00 34. ,42 M 0

ATOM 20681 OWO WAT M 278 8. ,268 -5. ,038 -51. ,658 1. 00 32. ,46 M 0

ATOM 20684 owo WAT M 279 47. ,217 -23. ,456 1. ,933 1. 00 66. ,95 M 0 cyno fD_Fab

ATOM 20687 OWO WAT M 280 -14.853 -28. 368 -59. ,133 1.00 59. 46 M 0

ATOM 20690 OWO WAT M 281 37. 222 -24. 247 -19. ,339 1.00 35. 18 M 0

ATOM 20693 OWO WAT M 282 -28. 062 -11. 254 -65. ,147 1.00 23. 28 M 0

ATOM 20696 OWO WAT M 283 19. 153 -48. 870 -54. ,179 1.00 32. 97 M 0

ATOM 20699 OWO WAT M 284 18. 096 -46. 750 -51. .008 1.00 35. 77 M 0

ATOM 20702 OWO WAT M 285 39 696 -7. 478 -38. ,142 1.00 37. 96 M 0

ATOM 20705 OWO WAT M 286 -17. 119 -22. 318 -60. .187 1.00 44. 41 M 0

ATOM 20708 OWO WAT M 287 28. 895 -39. 266 -81. ,605 1.00 34. 39 M 0

ATOM 20711 owo WAT M 288 44. 164 -59. 144 -70. ,482 1.00 26. 53 M 0

ATOM 20714 OWO WAT M 289 33. 107 -40. 826 -73. ,405 1.00 34. 79 M 0

ATOM 20717 owo WAT M 291 20. 915 -9. 083 -58. ,169 1.00 40. 42 M 0

ATOM 20720 OWO WAT M 292 42. 850 -44. 946 -43, ,707 1.00 44. 62 M 0

ATOM 20723 OWO WAT M 293 52. 787 -12. 518 -31. ,149 1.00 57. 81 M 0

ATOM 20726 OWO WAT M 294 57. 834 -61. 205 -15. ,578 1.00 59. 41 M 0

ATOM 20729 OWO WAT M 295 44. 343 -29. 933 -83. ,442 1.00 39. ,09 M 0

ATOM 20732 OWO WAT M 296 47. 442 -47. 618 -24. ,479 1.00 46. 94 M 0

ATOM 20735 OWO WAT M 297 -6. 527 3. 500 -35. ,886 1.00 58. 84 M 0

ATOM 20738 OWO WAT M 298 -8. 820 0. 874 -51. ,018 1.00 28. 32 M 0

ATOM 20741 OWO WAT M 299 24. 915 -8. 214 -28. .776 1.00 34. 48 M 0

ATOM 20744 OWO WAT M 300 24. 463 3. 357 -27. ,018 1.00 47. 53 M 0

ATOM 20747 OWO WAT M 301 35. Oil -39. 597 -81. ,067 1.00 30. 92 M 0

ATOM 20750 owo WAT M 302 48. 350 -30. 299 -68. ,338 1.00 15. 67 M 0

ATOM 20753 OWO WAT M 303 19. 895 -46. 110 -32. ,631 1.00 36. 01 M 0

ATOM 20756 OWO WAT M 304 -11. 105 -14. 521 -91.856 1.00 48. 66 M 0

ATOM 20759 OWO WAT M 305 44. 415 -25. 440 -63. ,348 1.00 41. 69 M 0

ATOM 20762 OWO WAT M 306 67. 272 -52. 831 -65. ,409 1.00 41. 62 M 0

ATOM 20765 OWO WAT M 307 39. 866 -7. 617 -40. ,709 1.00 50. 17 M 0

ATOM 20768 OWO WAT M 308 25. 337 -9. 638 -55. ,041 1.00 39. 09 M 0

ATOM 20771 OWO WAT M 309 21. 271 -44. 722 -27. ,408 1.00 29. 34 M 0

ATOM 20774 OWO WAT M 310 43. 969 -66. 640 -10, ,160 1.00 40. 77 M 0

ATOM 20777 OWO WAT M 311 32. 973 -60. 518 -28. ,444 1.00 34. 58 M 0

ATOM 20780 OWO WAT M 312 51.418 -61. 205 -62. ,864 1.00 38. 28 M 0

ATOM 20783 OWO WAT M 313 24. 400 -41.668 -64. ,362 1.00 38. 88 M 0

ATOM 20786 OWO WAT M 314 39. 709 -56. 452 -55. ,760 1.00 45. 26 M 0

ATOM 20789 OWO WAT M 315 45. 896 -36. 144 -66. ,896 1.00 5. 60 M 0

ATOM 20792 OWO WAT M 316 48. 670 -42. 039 -85. ,646 1.00 40. 07 M 0

ATOM 20795 OWO WAT M 317 15. 105 -40. 504 -52. ,720 1.00 40. 09 M 0

ATOM 20798 OWO WAT M 318 26. 363 -15. 529 -48, .335 1.00 18. 60 M 0

ATOM 20801 OWO WAT M 319 28. 102 -45. 304 -68, ,954 1.00 41. ,18 M 0

ATOM 20804 OWO WAT M 320 44. 528 -72. 016 -82, .839 1.00 36. ,67 M 0

ATOM 20807 OWO WAT M 321 18. 333 1. 791 -23, ,914 1.00 59. 64 M 0

ATOM 20810 OWO WAT M 322 -9. 923 -17. 749 -62, .750 1.00 19. 99 M 0

ATOM 20813 OWO WAT M 323 -22. 024 1. 433 -69. .296 1.00 36. 58 M 0

ATOM 20816 OWO WAT M 324 5. 312 -40. 149 -48. ,462 1.00 31. 65 M 0

ATOM 20819 OWO WAT M 325 42. 368 10. 604 -31.303 1.00 44. 36 M 0

ATOM 20822 OWO WAT M 326 39 484 -0. 450 -7, .068 1.00 63. ,90 M 0

ATOM 20825 owo WAT M 327 -18 770 13. 635 -73, .858 1.00 26. ,43 M 0

ATOM 20828 OWO WAT M 328 40 358 -10. 443 -41.286 1.00 44. 30 M 0

ATOM 20831 OWO WAT M 329 38. 631 -49. 988 -40, .798 1.00 50.18 M 0

ATOM 20834 OWO WAT M 330 21. 685 -44. 260 -36, .646 1.00 28. ,68 M 0

ATOM 20837 OWO WAT M 331 -37. 942 0. 101 -85, .721 1.00 60. ,19 M 0

ATOM 20840 OWO WAT M 332 -20. 528 3. 183 -65, .480 1.00 39. ,04 M 0

ATOM 20843 OWO WAT M 333 31.171 -33. 221 -40, .349 1.00 38. 44 M 0

ATOM 20846 owo WAT M 334 38 680 -18. 140 -44, .714 1.00 32. 29 M 0

ATOM 20849 OWO WAT M 335 35 258 -52. 507 -47, .145 1.00 38. ,35 M 0

ATOM 20852 OWO WAT M 336 -20 480 -14. 421 -90, .069 1.00 36. ,12 M 0

ATOM 20855 OWO WAT M 337 49 267 -20. 336 -36, .796 1.00 34. ,45 M 0

ATOM 20858 OWO WAT M 338 38 029 -13. 235 -48, ,617 1.00 39. ,98 M 0

ATOM 20861 OWO WAT M 339 54 476 -65. 570 -27, .666 1.00 36. ,72 M 0

ATOM 20864 OWO WAT M 340 8. 519 -26. 339 -40, .464 1.00 11. ,85 M 0

ATOM 20867 OWO WAT M 341 37. 431 -45. 522 -65, .348 1.00 16. ,29 M 0

ATOM 20870 OWO WAT M 342 42 491 -30. 249 -33, .808 1.00 47. ,17 M 0

ATOM 20873 OWO WAT M 343 37 345 -10. 992 -38, .649 1.00 30. ,59 M 0

ATOM 20876 OWO WAT M 344 56 376 -56. 621 -87 .679 1.00 24. ,42 M 0

ATOM 20879 OWO WAT M 346 56 469 -45. 206 -37, .553 1.00 42. ,32 M 0

ATOM 20882 OWO WAT M 347 20 328 -49. 406 -41, .374 1.00 31. ,43 M 0

ATOM 20885 OWO WAT M 348 52 136 -48. ,707 -96 .513 1.00 54. ,50 M 0

ATOM 20888 OWO WAT M 349 71 854 -44. 869 -51, .089 1.00 46. ,81 M 0 cyno fD_Fab

ATOM 20891 OWO WAT M 350 8 .244 1, ,179 -43, .400 1. 00 36, .23 M 0

ATOM 20894 OWO WAT M 351 10 .406 -38. ,596 -43, ,644 1. 00 32 .30 M 0

ATOM 20897 OWO WAT M 352 39 .862 -35. ,210 -72, ,512 1. 00 26, .18 M 0

ATOM 20900 OWO WAT M 353 39 .058 -28. ,333 -60, ,274 1. 00 21, .96 M 0

ATOM 20903 OWO WAT M 354 39 .010 -40. ,814 -6, ,690 1. 00 39, .00 M 0

ATOM 20906 OWO WAT M 355 44, .843 -56. ,441 -6. .414 1. 00 56, .98 M 0

ATOM 20909 OWO WAT M 356 32, .041 -41. ,933 -63. ,791 1. 00 15, ,02 M 0

ATOM 20912 OWO WAT M 357 56 .062 -63. ,330 -85. ,229 1. 00 34, .49 M 0

ATOM 20915 OWO WAT M 358 35, .301 -41. ,816 -72. ,218 1. 00 26, ,20 M 0

ATOM 20918 OWO WAT M 359 41, .794 -30. 618 -81. ,029 1. 00 48, ,94 M 0

ATOM 20921 OWO WAT M 360 32, .467 -45. ,574 -70, ,028 1. 00 32, ,96 M 0

ATOM 20924 owo WAT M 361 43, .401 -7. 879 -44. ,871 1. 00 32, ,10 M 0

ATOM 20927 OWO WAT M 363 -27, .014 -8. 244 -69. ,462 1. 00 46, .03 M 0

ATOM 20930 OWO WAT M 364 -34, .582 -11. 504 -90. ,373 1. 00 39, .81 M 0

ATOM 20933 OWO WAT M 365 30, ,215 -10. 601 -48. ,977 1. 00 60, ,57 M 0

ATOM 20936 owo WAT M 366 -5, .847 -27. 276 -59. ,940 1. 00 35, ,20 M 0

ATOM 20939 OWO WAT M 367 19, ,174 -48. 472 -57. ,532 1. 00 34. ,92 M 0

ATOM 20942 OWO WAT M 368 -38, ,776 -2. 050 -87. ,119 1. 00 52, ,58 M 0

ATOM 20945 OWO WAT M 369 43, ,979 -65. 925 -61. ,934 1. 00 38. .92 M 0

ATOM 20948 OWO WAT M 370 40, .856 -34. 086 -22. ,140 1. 00 49. ,90 M 0

ATOM 20951 OWO WAT M 371 41, ,164 -73. 496 -21. ,346 1. 00 34. ,37 M 0

ATOM 20954 OWO WAT M 372 37. .462 -72. ,181- ^• 110. ,052 1. 00 52. ,43 M 0

ATOM 20957 OWO WAT M 373 14. ,355 -26. 700 -39. ,247 1. 00 13. ,79 M 0

ATOM 20960 OWO WAT M 374 35. ,795 -12. 537 -57. 904 1. 00 40, ,83 M 0

ATOM 20963 OWO WAT M 375 49. ,107 -12. 435 -31. 838 1. 00 42. .68 M 0

ATOM 20966 OWO WAT M 376 50. ,015 -3. 729 -18. 360 1. 00 58. ,15 M 0

ATOM 20969 OWO WAT M 377 -37, ,908 -2. 270 -82. ,388 1. 00 37. ,27 M 0

ATOM 20972 OWO WAT M 378 0. ,411 -13. 677 -65. 747 1. 00 29. ,64 M 0

ATOM 20975 OWO WAT M 379 -31. ,482 -11. 249 -79. 765 1. 00 30. ,63 M 0

ATOM 20978 OWO WAT M 380 -18. ,858 13. 648 -76. 463 1. 00 22. ,86 M 0

ATOM 20981 OWO WAT M 381 39. ,572 -60. 429 -71. 177 1. 00 36. ,53 M 0

ATOM 20984 OWO WAT M 382 70. ,770 -45. 988 -48. 635 1. 00 45. ,74 M 0

ATOM 20987 OWO WAT M 383 35. ,691 -8. 744 -45. ,545 1. 00 61. ,26 M 0

ATOM 20990 OWO WAT M 384 -17. ,227 9. 921 -76. 261 1. 00 31. ,77 M 0

ATOM 20993 owo WAT M 385 -3. ,030 -12. 310 -90. 631 1. 00 61.27 M 0

ATOM 20996 OWO WAT M 386 55. ,227 -61. 972 -14. 169 1. 00 49. ,61 M 0

ATOM 20999 OWO WAT M 387 58. ,027 -20. 402 -13. 833 1. 00 65. 05 M 0

ATOM 21002 OWO WAT M 388 62. ,076 -58. 928 -85. ,518 1. 00 34. 94 M 0

ATOM 21005 OWO WAT M 389 -3. ,319 -2. 971 -62. 583 1. 00 31.66 M 0

ATOM 21008 OWO WAT M 390 14. ,036 -9. 490 -43. 872 1. 00 19. 90 M 0

ATOM 21011 OWO WAT M 391 15. Oil -11. 786 -44. 411 1. 00 19. ,55 M 0

ATOM 21014 OWO WAT M 392 14. ,519 -12. 647 -46. 797 1. 00 22. 83 M 0

ATOM 21017 OWO WAT M 393 15. ,378 -12. 089 -49. 994 1. 00 22. 10 M 0

ATOM 21020 OWO WAT M 394 61.287 -35. 058 -55. 325 1. 00 15. 07 M 0

ATOM 21023 OWO WAT M 395 5. ,200 -33. 405 -36. Oil 1. 00 27. ,47 M 0

ATOM 21026 OWO WAT M 396 27. ,231 -32. 456 -49. 693 1. 00 13. ,66 M 0

ATOM 21029 OWO WAT M 397 25. ,641 -34. 647 -49. 012 1. 00 19. 67 M 0

ATOM 21032 OWO WAT M 398 28. ,653 -30. 471 -50. ,144 1. 00 21. 43 M 0

ATOM 21035 OWO WAT M 399 7. ,315 -6. 796 -53. 179 1. 00 22. 99 M 0

ATOM 21038 owo WAT M 400 -6. ,201 -17. 176 -78. 996 1. 00 31. 48 M 0

ATOM 21041 OWO WAT M 401 45. ,670 -41.977 -71. 767 1. 00 25. ,22 M 0

ATOM 21044 owo WAT M 402 48. ,028 -40. 349 -71. 324 1. 00 21. 73 M 0

ATOM 21047 OWO WAT M 403 45. ,046 -43. 142 -69. 604 1. 00 14. 84 M 0

ATOM 21050 OWO WAT M 404 26. ,612 -31. 703 -61.308 1. 00 17. 64 M 0

ATOM 21053 owo WAT M 405 27. ,341 -34. 063 -61. 533 1. 00 17. ,54 M 0

ATOM 21056 OWO WAT M 406 25. ,585 -22. 442 -57. 994 1. 00 19. ,59 M 0

ATOM 21059 OWO WAT M 407 55. ,070 -62. 023 -77. 592 1. 00 17. 92 M 0

ATOM 21062 OWO WAT M 408 25. 232 -39. 080 -65. 600 1. 00 26. 50 M 0

ATOM 21065 OWO WAT M 409 18. 971 -20. 317 -31.727 1. 00 21. 90 M 0

ATOM 21068 owo WAT M 410 -12. 546 -2. 538 -50. 057 1. 00 32. 25 M 0

ATOM 21071 OWO WAT M 411 21.115 -11. 807 -57. 983 1. 00 26. 74 M 0

ATOM 21074 OWO WAT M 412 9. ,607 -33. 809 -61.795 1. 00 24. 89 M 0

ATOM 21077 owo WAT M 413 44. 485 -29. 213 -67. 347 1. 00 24. 33 M 0

ATOM 21080 OWO WAT M 414 16. 403 -27. 709 -62. 404 1. 00 35. 33 M 0

ATOM 21083 OWO WAT M 415 7. 691 -28. 407 -32. 028 1. 00 43. 48 M 0

ATOM 21086 owo WAT M 416 40. 079 -58. 369 -65. 262 1. 00 30. 98 M 0

ATOM 21089 OWO WAT M 417 -9. 116 -24. 813 -82. 829 1. 00 20. 21 M 0

ATOM 21092 OWO WAT M 418 56. 996 -38. 359 -66. 357 1. 00 23. 16 M 0 cyno fD_Fab

ATOM 21095 OWO WAT M 419 29. ,994 -31.313 -66. ,722 1. 00 23. ,58 M 0

ATOM 21098 OWO WAT M 420 39. ,737 -50. 634 -64. ,166 1. 00 24. ,65 M 0

ATOM 21101 OWO WAT M 421 6. ,280 -21.556 -54. ,205 1. 00 11. ,77 M 0

ATOM 21104 OWO WAT M 422 62. ,768 -56. 576 -66. ,528 1. 00 29. ,64 M 0

ATOM 21107 OWO WAT M 423 1. ,947 -34. 646 -41. ,599 1. 00 45. ,06 M 0

ATOM 21110 OWO WAT M 424 52. 923 -45. ,625 -71. ,408 1. 00 26. 82 M 0

ATOM 21113 OWO WAT M 425 -13. ,647 -7. 528 -49. ,386 1. 00 24. ,31 M 0

ATOM 21116 owo WAT M 426 -26. ,155 -5. 382 -84. ,106 1. 00 25. ,40 M 0

ATOM 21119 OWO WAT M 427 17. ,752 -32. 337 -57. ,445 1. 00 20. ,30 M 0

ATOM 21122 owo WAT M 428 19. ,541 -11. 451 -42. ,838 1. 00 29. ,00 M 0

ATOM 21125 OWO WAT M 429 21.655 -26. 948 -57. ,734 1. 00 14. ,90 M 0

ATOM 21128 owo WAT M 430 49. ,503 -13. 082 -27. ,324 1. 00 41. ,39 M 0

ATOM 21131 OWO WAT M 431 40. ,791 -63. 010 -78. ,897 1. 00 22.23 M 0

ATOM 21134 OWO WAT M 432 -5. 460 -13. 118 -76. ,798 1. 00 24. ,38 M 0

ATOM 21137 owo WAT M 433 -2. 286 -23. 273 -69. ,959 1. 00 30. ,11 M 0

ATOM 21140 OWO WAT M 434 67. 030 -57. 639 -64. ,529 1. 00 36. ,51 M 0

ATOM 21143 OWO WAT M 435 34. 947 -26. 298 -39. ,600 1. 00 31. ,04 M 0

ATOM 21146 OWO WAT M 436 -5. 663 -9. 241 -30. 501 1. 00 45. ,59 M 0

ATOM 21149 owo WAT M 437 44. 785 -44. 930 -59. 569 1. 00 12. ,23 M 0

ATOM 21152 OWO WAT M 438 1. 561 -31. 854 -58. 890 1. 00 21. ,50 M 0

ATOM 21155 owo WAT M 439 -6. ,323 -14. 848 -84. ,012 1. 00 33. ,34 M 0

ATOM 21158 OWO WAT M 440 -5. ,276 -25. 386 -38. ,794 1. 00 28. ,28 M 0

ATOM 21161 owo WAT M 441 7. ,667 -4. 051 -26. 893 1. 00 38. ,28 M 0

ATOM 21164 OWO WAT M 442 51. 203 -66. 029 -62. ,070 1. 00 34. ,77 M 0

ATOM 21167 OWO WAT M 443 31. 607 -15. 817 -22. 006 1. 00 27. ,23 M 0

ATOM 21170 OWO WAT M 444 1. 964 -6. 256 -60. 692 1. 00 29. ,53 M 0

ATOM 21173 OWO WAT M 445 22. 233 -19. 103 -25. 109 1. 00 33. .82 M 0

ATOM 21176 OWO WAT M 446 37. 209 -2. 357 -10. 730 1. 00 41. ,78 M 0

ATOM 21179 OWO WAT M 447 46. 591 -37. ,495 -56. ,735 1. 00 19. ,78 M 0

ATOM 21182 OWO WAT M 448 47. 703 -46. 018 -45. .948 1. 00 24. ,30 M 0

ATOM 21185 OWO WAT M 449 51.062 -58. 894 -72. 621 1. 00 17. ,19 M 0

ATOM 21188 owo WAT M 450 40. 855 -28. 256 -53. 103 1. 00 31. ,25 M 0

ATOM 21191 OWO WAT M 451 37. 008 -30. 829 -42. 263 1. 00 32. 88 M 0

ATOM 21194 OWO WAT M 452 7. 222 1. 349 -49. Oil 1. 00 33. ,73 M 0

ATOM 21197 OWO WAT M 453 -3. ,007 -24. 678 -49. ,295 1. 00 19. ,34 M 0

ATOM 21200 owo WAT M 454 33. 955 -29. 833 -55. ,991 1. 00 17. ,98 M 0

ATOM 21203 OWO WAT M 455 -22. 530 -7. 961 -78. ,047 1. 00 20. ,93 M 0

ATOM 21206 OWO WAT M 456 -15. 322 -20. 501 -85. 131 1. 00 23. ,76 M 0

ATOM 21209 OWO WAT M 457 12. 064 -35. 182 -58. ,437 1. 00 33. ,09 M 0

ATOM 21212 OWO WAT M 458 44. 454 -31. 611 -58. ,219 1. 00 22. ,83 M 0

ATOM 21215 OWO WAT M 459 -13. 526 -12. 979 -72. ,662 1. 00 19. ,48 M 0

ATOM 21218 OWO WAT M 460 27. 934 -33. 264 -65. 550 1. 00 27. ,93 M 0

ATOM 21221 OWO WAT M 461 35. 926 -26. 819 -64. ,730 1. 00 27. ,45 M 0

ATOM 21224 owo WAT M 462 49. 400 -38. 267 -48. ,737 1. 00 22. ,50 M 0

ATOM 21227 OWO WAT M 463 50. 809 -58. 201 -81. ,883 1. 00 22. ,25 M 0

ATOM 21230 owo WAT M 464 5. 666 -4. 676 -51. ,349 1. 00 20. .41 M 0

ATOM 21233 OWO WAT M 465 37. ,647 -28. ,230 -71. ,211 1. 00 22, .21 M 0

ATOM 21236 owo WAT M 466 42. ,830 -27. 621 -41.931 1. 00 41.22 M 0

ATOM 21239 OWO WAT M 467 50. ,315 -34. 663 -12. ,566 1. 00 39, .94 M 0

ATOM 21242 owo WAT M 468 17. ,559 -35. 999 -41. ,770 1. 00 37, .09 M 0

ATOM 21245 OWO WAT M 469 21. ,691 -41. ,946 -23. ,375 1. 00 43, .11 M 0

ATOM 21248 OWO WAT M 470 65. ,462 -51. ,424 -49. .700 1. 00 27, .34 M 0

ATOM 21251 OWO WAT M 471 17. ,199 -17. ,238 -61. .379 1. 00 27, .38 M 0

ATOM 21254 OWO WAT M 472 53. ,087 -48. ,284 -77. ,979 1. 00 21, .86 M 0

ATOM 21257 owo WAT M 473 39. 726 -10. ,594 -33. ,090 1. 00 52, .53 M 0

ATOM 21260 OWO WAT M 474 37. 294 -46. 529 -95. ,772 1. 00 28, .76 M 0

ATOM 21263 OWO WAT M 475 59. 737 -60. 396 -56. ,210 1. 00 21, .00 M 0

ATOM 21266 owo WAT M 476 7. ,565 -11. ,135 -47. ,722 1. 00 18. .49 M 0

ATOM 21269 OWO WAT M 477 1. ,651 -29. ,812 -40. .989 1. 00 32, .76 M 0

ATOM 21272 owo WAT M 478 67. ,211 -36. ,121 -46. ,233 1. 00 35, .11 M 0

ATOM 21275 OWO WAT M 479 -26. ,374 -18. ,269 -69. ,912 1. 00 26, .49 M 0

ATOM 21278 OWO WAT M 480 -8. ,780 -3. ,341 -49. ,781 1. 00 27, .70 M 0

ATOM 21281 owo WAT M 481 51. ,874 -34. ,322 -58. ,440 1. 00 20, .09 M 0

ATOM 21284 OWO WAT M 482 38. ,147 -15. ,991 -51. ,696 1. 00 32, .80 M 0

ATOM 21287 OWO WAT M 483 12. ,425 -5. ,343 -38. ,083 1. 00 26, .36 M 0

ATOM 21290 owo WAT M 484 -14. ,141 -19. ,902 -74. ,173 1. 00 16, .76 M 0

ATOM 21293 owo WAT M 485 52. ,620 -29. ,946 -65. ,436 1. 00 33, .33 M 0

ATOM 21296 OWO WAT M 486 -8. ,957 -30. ,148 -77. ,690 1. 00 33, .33 M 0 cyno fD_Fab

ATOM 21299 OWO WAT M 487 -15. ,731 -14. 002 -86. ,167 1. 00 29. 57 M 0

ATOM 21302 OWO WAT M 488 29. 641 -54. 046 -41.106 1. 00 40. 87 M 0

ATOM 21305 OWO WAT M 489 36. 590 -20. 413 -56. ,724 1. 00 32. 47 M 0

ATOM 21308 OWO WAT M 490 31. 344 -15. 311 -18. ,596 1. 00 32. 99 M 0

ATOM 21311 OWO WAT M 491 -8. 534 -14. 349 -37. ,230 1. 00 33. 63 M 0

ATOM 21314 OWO WAT M 492 37. 563 -18. 055 -54. ,283 1. 00 34. 70 M 0

ATOM 21317 OWO WAT M 493 54. 050 -54. 095 -45. .905 1. 00 18. 25 M 0

ATOM 21320 OWO WAT M 494 0. 194 -21.826 -50. ,992 1. 00 19. 06 M 0

ATOM 21323 OWO WAT M 495 16. 544 -29. 256 -36. ,778 1. 00 32. 90 M 0

ATOM 21326 OWO WAT M 496 13. 020 -25. 079 -33. ,142 1. 00 26. 97 M 0

ATOM 21329 OWO WAT M 497 -9. 519 -18. 166 -78. 763 1. 00 31.87 M 0

ATOM 21332 OWO WAT M 498 -21.864 -21. 244 -93. 001 1. 00 43. 69 M 0

ATOM 21335 owo WAT M 499 38. 932 -24. 963 -57. ,225 1. 00 43. 58 M 0

ATOM 21338 OWO WAT M 500 34. 759 -27. 089 -56. ,474 1. 00 39. 59 M 0

ATOM 21341 OWO WAT M 501 51. 735 -60. 894 -83. ,751 1. 00 27. 64 M 0

ATOM 21344 OWO WAT M 502 -13. 102 -14. 088 -75. ,358 1. 00 20. 49 M 0

ATOM 21347 OWO WAT M 503 37. 801 -77. 159 -93. ,534 1. 00 38. 06 M 0

ATOM 21350 OWO WAT M 504 19. Oil -20. 908 -59. ,429 1. 00 22. 73 M 0

ATOM 21353 OWO WAT M 505 39. 614 -61. 775 -66. ,340 1. 00 44. 31 M 0

ATOM 21356 OWO WAT M 506 61. 743 -44. 056 -64. ,619 1. 00 24. 08 M 0

ATOM 21359 OWO WAT M 507 -10. 196 -24. 430 -55. 639 1. 00 42. 83 M 0

ATOM 21362 OWO WAT M 508 -15. 417 -5. 380 -49. ,844 1. 00 29. 79 M 0

ATOM 21365 OWO WAT M 509 -2. 906 -31. 915 -41. ,544 1. 00 39. 27 M 0

ATOM 21368 OWO WAT M 510 54. 255 -61. 202 -68. ,808 1. 00 36. 67 M 0

ATOM 21371 OWO WAT M 511 52. 102 -3. 937 -24. ,151 1. 00 53. 19 M 0

ATOM 21374 OWO WAT M 512 70. 152 -41. 675 -51. ,096 1. 00 26. 14 M 0

ATOM 21377 OWO WAT M 513 12. 121 -8. 573 -30. ,014 1. 00 30. 41 M 0

ATOM 21380 OWO WAT M 514 5. 663 -26. 999 -39. ,943 1. 00 29. 78 M 0

ATOM 21383 OWO WAT M 515 45. 412 -61. 583 -16. ,631 1. 00 32. 81 M 0

ATOM 21386 OWO WAT M 516 46. 521 -50. 242 -45. ,864 1. 00 29. 76 M 0

ATOM 21389 OWO WAT M 517 29. 945 -21. 983 -36. ,901 1. 00 23. 78 M 0

ATOM 21392 OWO WAT M 518 -21. 479 -26. 460 -73. ,199 1. 00 28. 51 M 0

ATOM 21395 OWO WAT M 519 -8. 472 -11. 698 -34. ,975 1. 00 39. 60 M 0

ATOM 21398 OWO WAT M 520 -20. 027 -10. 165 -79. ,638 1. 00 21. 53 M 0

ATOM 21401 OWO WAT M 521 14. 644 -33. 226 -59. ,242 1. 00 25. 56 M 0

ATOM 21404 OWO WAT M 522 57. 444 -56. 105 -84. ,829 1. 00 31. 11 M 0

ATOM 21407 OWO WAT M 523 11.389 -6. 247 -41. ,845 1. 00 28. 82 M 0

ATOM 21410 OWO WAT M 524 43. 355 -38. 733 -21. ,227 1. 00 31. 35 M 0

ATOM 21413 OWO WAT M 525 6. 801 -1. 519 -38. ,913 1. 00 33. 33 M 0

ATOM 21416 OWO WAT M 526 -4. 348 -13. 735 -30. ,142 1. 00 42. 57 M 0

ATOM 21419 OWO WAT M 527 43. 786 -37. 403 -51. ,764 1. 00 21. 10 M 0

ATOM 21422 OWO WAT M 528 41. 585 -34. 782 -88. ,114 1. 00 33. 93 M 0

ATOM 21425 OWO WAT M 529 46. 671 -22. 711 -2. ,830 1. 00 31. 60 M 0

ATOM 21428 OWO WAT M 530 17. 851 -19. 184 -24. ,467 1. 00 36. 02 M 0

ATOM 21431 OWO WAT M 531 49. 300 -15. 784 -27. ,255 1. 00 37. 19 M 0

ATOM 21434 OWO WAT M 532 14. 537 -7. 715 -39. ,740 1. 00 34. 92 M 0

ATOM 21437 OWO WAT M 533 26. ,029 -20. 696 -59. ,771 1. 00 27. 11 M 0

ATOM 21440 OWO WAT M 534 36. 163 -26. 017 -28. ,426 1. 00 35. 10 M 0

ATOM 21443 OWO WAT M 535 -4. 814 4. 588 -82. ,163 1. 00 37. 10 M 0

ATOM 21446 OWO WAT M 536 17. 502 -9. 988 -35. .729 1. 00 39. 42 M 0

ATOM 21449 owo WAT M 537 25. 623 -21. ,910 -38. ,629 1. 00 27. 75 M 0

ATOM 21452 OWO WAT M 538 57. 726 -66. 521 -58. .305 1. 00 39. 28 M 0

ATOM 21455 OWO WAT M 539 13. ,149 -13. ,874 -22. ,983 1. 00 29. 22 M 0

ATOM 21458 OWO WAT M 540 -4. 238 -21. 492 -63. ,608 1. 00 20. 38 M 0

ATOM 21461 OWO WAT M 541 40. 304 -23. 398 -5. ,002 1. 00 38. 81 M 0

ATOM 21464 OWO WAT M 542 9. 114 -32. 600 -42. ,057 1. 00 25. 99 M 0

ATOM 21467 OWO WAT M 543 36. 196 -53. 182 -95, ,103 1. 00 23. 10 M 0

ATOM 21470 OWO WAT M 544 15. 628 -26. 173 -55, ,259 1. 00 23. 22 M 0

ATOM 21473 OWO WAT M 545 62. 385 -59. 098 -56, ,148 1. 00 32. 00 M 0

ATOM 21476 OWO WAT M 546 20. 218 -21. ,832 -37. ,784 1. 00 25. 77 M 0

ATOM 21479 OWO WAT M 547 19. 204 -10. 029 -38, .770 1. 00 35. ,96 M 0

ATOM 21482 OWO WAT M 548 17. 827 -35. ,204 -48, .552 1. 00 17. ,13 M 0

ATOM 21485 OWO WAT M 549 13. ,345 -11. ,635 -51, .778 1. 00 26. ,69 M 0

ATOM 21488 OWO WAT M 550 56. 671 -56. ,713 -78. ,477 1. 00 19. ,48 M 0

ATOM 21491 owo WAT M 551 -7. 793 -15. 891 -34. ,975 1. 00 34. 04 M 0

ATOM 21494 OWO WAT M 552 -5. 155 -22. ,116 -80. .280 1. 00 26. ,48 M 0

ATOM 21497 OWO WAT M 553 0. 445 -6. ,248 -53. .997 1. 00 24. 89 M 0

ATOM 21500 OWO WAT M 554 -11. 479 -16. 352 -50, ,937 1. 00 30. 55 M 0 cyno fD_Fab

ATOM 21503 OWO WAT M 555 32. ,236 -26. 577 -63. 276 1. 00 39. ,16 M 0

ATOM 21506 OWO WAT M 556 45. ,738 -61. 897 -67. 607 1. 00 28. ,05 M 0

ATOM 21509 OWO WAT M 557 49. ,185 -43. 993 -44. 216 1. 00 33. ,16 M 0

ATOM 21512 OWO WAT M 558 -12. ,334 -16. 697 -84. 837 1. 00 36. 26 M 0

ATOM 21515 OWO WAT M 559 28. 500 -19. 665 -60. 873 1. 00 33. 82 M 0

ATOM 21518 OWO WAT M 560 46. ,449 -37. 509 -25. 730 1. 00 32. ,43 M 0

ATOM 21521 OWO WAT M 561 1. ,349 -7. 396 -27. 787 1. 00 41. ,01 M 0

ATOM 21524 OWO WAT M 562 -4. ,947 -23. 771 -32. 636 1. 00 49. 08 M 0

ATOM 21527 OWO WAT M 563 38. ,455 -25. 525 -53. 315 1. 00 25. 69 M 0

ATOM 21530 OWO WAT M 564 7. 839 -32. 766 -34. 964 1. 00 42. ,94 M 0

ATOM 21533 OWO WAT M 565 55. ,225 -58. 929 -46. 898 1. 00 28. ,56 M 0

ATOM 21536 OWO WAT M 566 54. 139 -39. 498 -22. 877 1. 00 35. ,47 M 0

ATOM 21539 owo WAT M 567 28. 312 -21. 090 -30. 345 1. 00 36. ,90 M 0

ATOM 21542 OWO WAT M 568 -14. 094 -4. 209 -57. 103 1. 00 17. ,73 M 0

ATOM 21545 OWO WAT M 569 48. ,822 -35. 906 -61. 013 1. 00 28. ,34 M 0

ATOM 21548 OWO WAT M 570 36. ,997 -34. 164 -72. 752 1. 00 17. ,70 M 0

ATOM 21551 OWO WAT M 571 31. 142 -22. 381 -32. 871 1. 00 31.88 M 0

ATOM 21554 OWO WAT M 572 6. 066 -33. 997 -33. 843 1. 00 36. ,12 M 0

ATOM 21557 OWO WAT M 573 -6. 868 -6. 501 -68. 030 1. 00 21. ,80 M 0

ATOM 21560 OWO WAT M 574 61. 385 -31. 023 -46. 441 1. 00 40. ,57 M 0

ATOM 21563 OWO WAT M 575 51.881 -62. 118 -55. 572 1. 00 30. ,33 M 0

ATOM 21566 OWO WAT M 576 -24. 465 -15. 192 -73. 229 1. 00 23. ,04 M 0

ATOM 21569 OWO WAT M 577 27. 180 -3. 327 -12. 434 1. 00 37. ,93 M 0

ATOM 21572 OWO WAT M 578 17. ,746 -37. 508 -47. 314 1. 00 26. ,99 M 0

ATOM 21575 OWO WAT M 579 -24. 323 1. 666 -85. 718 1. 00 35. ,44 M 0

ATOM 21578 OWO WAT M 580 18. ,344 -32. 521 -37. 368 1. 00 33. ,91 M 0

ATOM 21581 OWO WAT M 581 45. ,070 -65. 115 -66. 786 1. 00 47. ,02 M 0

ATOM 21584 OWO WAT M 582 37. 099 -26. 589 -25. 718 1. 00 43. ,44 M 0

ATOM 21587 OWO WAT M 583 28. 564 -36. 192 -17. 960 1. 00 39. ,91 M 0

ATOM 21590 OWO WAT M 584 42. 836 -37. 758 -94. 545 1. 00 24. ,48 M 0

ATOM 21593 OWO WAT M 585 57. 195 -38. 132 -39. 975 1. 00 39. ,28 M 0

ATOM 21596 OWO WAT M 586 6. 017 -28. 445 -37. 538 1. 00 31. ,36 M 0

ATOM 21599 OWO WAT M 587 54. 387 -60. 834 -98. 425 1. 00 38. ,27 M 0

ATOM 21602 OWO WAT M 588 0. ,926 -8. 799 -43. 833 1. 00 22. ,75 M 0

ATOM 21605 OWO WAT M 589 15. 375 -38. 583 -42. 065 1. 00 47. ,58 M 0

ATOM 21608 OWO WAT M 590 7. 535 -35. 906 -58. 561 1. 00 22. ,77 M 0

ATOM 21611 OWO WAT M 591 45. ,538 -8. 783 -9. 739 1. 00 38. ,32 M 0

ATOM 21614 OWO WAT M 592 62. ,506 -32. 178 -41. 581 1. 00 41.88 M 0

ATOM 21617 OWO WAT M 593 59. 638 -43. 057 -69. 886 1. 00 30. ,16 M 0

ATOM 21620 OWO WAT M 594 32. 646 -55. 714- ^■ 112. 456 1. 00 47. ,72 M 0

ATOM 21623 OWO WAT M 595 30. 783 -54. 896 -16. 393 1. 00 44. ,19 M 0

ATOM 21626 OWO WAT M 596 -27. 349 3. 594 -73. 874 1. 00 45. ,04 M 0

ATOM 21629 OWO WAT M 597 48. ,454 -46. 729 -0. 339 1. 00 40. ,47 M 0

ATOM 21632 OWO WAT M 598 46. ,099 -36. 095 -54. 587 1. 00 36. ,54 M 0

ATOM 21635 OWO WAT M 599 -6. ,437 -18. 281 -46. 462 1. 00 29. ,79 M 0

ATOM 21638 OWO WAT M 600 45. ,360 -36. 857 -16. 481 1. 00 41. ,28 M 0

ATOM 21641 OWO WAT M 601 64. ,881 -39. 115 -36. 379 1. 00 39. ,58 M 0

ATOM 21644 OWO WAT M 602 28. 236 -22. 600 -39. 847 1. 00 23. ,66 M 0

ATOM 21647 owo WAT M 603 21. ,512 -18. 921 -59. 664 1. 00 25. ,27 M 0

ATOM 21650 OWO WAT M 604 25. ,225 -39. 077 -58. 403 1. 00 24. ,98 M 0

ATOM 21653 owo WAT M 605 5. ,542 -32. 281 -60. 611 1. 00 13. ,32 M 0

ATOM 21656 OWO WAT M 606 7. ,921 -19. 603 -44. 866 1. 00 16. ,24 M 0

ATOM 21659 OWO WAT M 607 55. ,141 -37. 873 -44. ,225 1. 00 37. ,35 M 0

ATOM 21662 OWO WAT M 608 53. ,834 -47. 240 -75. ,787 1. 00 23. ,84 M 0

ATOM 21665 OWO WAT M 609 19. 088 -12. 646 -59. ,463 1. 00 37. ,74 M 0

ATOM 21668 OWO WAT M 610 33. ,510 -63. 261 -79. ,622 1. 00 33. ,30 M 0

ATOM 21671 OWO WAT M 611 20. 804 -22. ,349 -35. ,012 1. 00 42. ,20 M 0

ATOM 21674 OWO WAT M 612 -9. 682 -20. 622 -40. ,682 1. 00 46. ,33 M 0

ATOM 21677 OWO WAT M 613 20. ,633 -27. 659 -38. ,330 1. 00 23. ,48 M 0

ATOM 21680 OWO WAT M 614 52. ,090 -33. 590 -49. ,955 1. 00 32. ,56 M 0

ATOM 21683 owo WAT M 615 50. ,716 -35. 162 -54. ,657 1. 00 24. ,70 M 0

ATOM 21686 OWO WAT M 616 38. ,651 -26. 505 -61. ,576 1. 00 43, ,71 M 0

ATOM 21689 OWO WAT M 617 43. ,425 -33. ,910 -71. ,567 1. 00 31. .18 M 0

ATOM 21692 owo WAT M 618 36. ,830 -48. 731- -110. ,446 1. 00 41, .19 M 0

ATOM 21695 OWO WAT M 619 34. ,901 -0. 219 -13. ,019 1. 00 47. ,34 M 0

ATOM 21698 OWO WAT M 620 -19. ,858 6. 404 -77. ,003 1. 00 25. .52 M 0

ATOM 21701 owo WAT M 621 38. ,510 -60. 264 -73. ,506 1. 00 26. ,78 M 0

ATOM 21704 OWO WAT M 622 31. ,515 -33. 670 -71. ,980 1. 00 36. ,81 M 0 cyno fD_Fab

ATOM 21707 OWO WAT M 623 -2. 291 5. 433 -62. ,832 1.00 43. 39 M 0

ATOM 21710 OWO WAT M 624 35. 919 -21. 498 -59. ,571 1.00 37. 73 M 0

ATOM 21713 OWO WAT M 625 50. 245 -70. 023 -79. ,904 1.00 29. 35 M 0

ATOM 21716 OWO WAT M 626 4. 528 -37. 803 -55. .213 1.00 31. ,92 M 0

ATOM 21719 OWO WAT M 627 43. 201 -9. ,310 -8. ,097 1.00 38. ,20 M 0

ATOM 21722 OWO WAT M 628 14. 513 -7. 179 -46. ,801 1.00 48. ,11 M 0

ATOM 21725 OWO WAT M 629 42. 831 -21.277 -45. ,455 1.00 38. 65 M 0

ATOM 21728 OWO WAT M 630 19. 335 -26. 966 -63. ,218 1.00 31. 13 M 0

ATOM 21731 OWO WAT M 631 14. 637 -25. 627 -60. ,097 1.00 32. 38 M 0

ATOM 21734 OWO WAT M 632 -15. 363 -11. 871 -88. ,260 1.00 43. 98 M 0

ATOM 21737 owo WAT M 633 35. 124 -31. 692 -10. ,109 1.00 49. 70 M 0

ATOM 21740 OWO WAT M 634 44. 882 -44. 216 -78. ,940 1.00 37. 79 M 0

ATOM 21743 OWO WAT M 635 14. 634 -28. 510 -34. ,754 1.00 33. ,96 M 0

ATOM 21746 OWO WAT M 636 48. 609 -35. 633 -70. ,127 1.00 31. ,76 M 0

ATOM 21749 OWO WAT M 637 -9. 408 -23. 846 -40. ,155 1.00 37. 29 M 0

ATOM 21752 OWO WAT M 638 39. 385 -70. 055 -19. ,671 1.00 47. 36 M 0

ATOM 21755 OWO WAT M 639 30. 746 -37. 701 -35. ,300 1.00 35. 56 M 0

ATOM 21758 OWO WAT M 640 -2. 150 -10. 812 -86. ,771 1.00 42. 84 M 0

ATOM 21761 OWO WAT M 641 19. 433 -32. 368 -40. ,075 1.00 41. 76 M 0

ATOM 21764 owo WAT M 642 19. 891 -22. 107 -21. ,302 1.00 38. 58 M 0

ATOM 21767 OWO WAT M 643 37. 115 -37. 030 -27. .830 1.00 46. 24 M 0

ATOM 21770 owo WAT M 644 52. 913 -63. 067 -65. ,939 1.00 25. ,87 M 0

ATOM 21773 OWO WAT M 645 40. 293 -42. 193 -95. ,322 1.00 37. 86 M 0

ATOM 21776 OWO WAT M 646 54. 474 -41. 636 -38. ,276 1.00 38. 74 M 0

ATOM 21779 OWO WAT M 647 1. 335 -19. 986 -14. ,091 1.00 35. 23 M 0

ATOM 21782 OWO WAT M 648 -12. 155 -6. 692 -56. ,221 1.00 22. 59 M 0

ATOM 21785 OWO WAT M 649 38. 499 -28. 994 -52. ,228 1.00 22. 08 M 0

ATOM 21788 OWO WAT M 650 45. 513 -67. 734 -31. ,020 1.00 40. 40 M 0

ATOM 21791 OWO WAT M 651 16. 342 -16. 722 -21. ,425 1.00 36. 04 M 0

ATOM 21794 OWO WAT M 652 62. 974 -54. 787 -53. ,130 1.00 35. ,00 M 0

ATOM 21797 OWO WAT M 653 52. 375 -39. 690 -20. ,717 1.00 38. 20 M 0

ATOM 21800 OWO WAT M 654 39. 076 -39. 672 -92. ,978 1.00 38. 59 M 0

ATOM 21803 OWO WAT M 655 -14. 652 -22. 356 -53. ,130 1.00 41.80 M 0

ATOM 21806 OWO WAT M 656 -4. 040 -4. 791 -65. ,073 1.00 32. 05 M 0

ATOM 21809 OWO WAT M 657 27. 312 -47. 134 -24. ,462 1.00 32. 55 M 0

ATOM 21812 OWO WAT M 658 -8. 891 -6. 337 -37. .347 1.00 34. 84 M 0

ATOM 21815 OWO WAT M 659 -6. 078 -11. 420 -27. ,412 1.00 51. 65 M 0

ATOM 21818 OWO WAT M 660 40. 763 -60. 900 -34, .090 1.00 29. ,14 M 0

ATOM 21821 OWO WAT M 661 44. 902 -41. 309 -74, .105 1.00 38. ,79 M 0

ATOM 21824 OWO WAT M 662 29. 171 -26. 084 -64, .063 1.00 43. ,74 M 0

ATOM 21827 OWO WAT M 663 1. 457 -3. ,041 -50. .847 1.00 29. 18 M 0

ATOM 21830 OWO WAT M 664 28. 422 -15. 382 -42. .820 1.00 29. 07 M 0

ATOM 21833 OWO WAT M 665 18. 165 -24. 793 -62. .438 1.00 33. 16 M 0

ATOM 21836 OWO WAT M 666 -10. 548 -1. ,067 -88. .149 1.00 42. 65 M 0

ATOM 21839 owo WAT M 667 46. 417 -44. 587 -25. .146 1.00 39. 73 M 0

ATOM 21842 OWO WAT M 668 32. 085 -24. ,050 -59, .896 1.00 38. 93 M 0

ATOM 21845 owo WAT M 669 3. 190 -19. ,906 -67, .640 1.00 32. ,41 M 0

ATOM 21848 OWO WAT M 670 4. 786 -28. 297 -42, ,151 1.00 26. ,69 M 0

ATOM 21851 OWO WAT M 671 52. 183 -29. ,282 -33, .856 1.00 46. ,68 M 0

ATOM 21854 OWO WAT M 672 33. 581 -28. 589 -70, .543 1.00 48. ,01 M 0

ATOM 21857 OWO WAT M 673 43. 184 -40. ,665 -31, .328 1.00 45. 82 M 0

ATOM 21860 OWO WAT M 674 26. 221 -52. ,908 -47, .071 1.00 44. ,78 M 0

ATOM 21863 OWO WAT M 675 7. 081 -15. ,497 -58, ,152 1.00 23. ,77 M 0

ATOM 21866 owo WAT M 676 21. 531 -45. ,630 -56. .306 1.00 32. ,55 M 0

ATOM 21869 OWO WAT M 677 6. 718 -7. ,925 -64, .684 1.00 43. ,17 M 0

ATOM 21872 OWO WAT M 678 26. 137 -53. ,752 -94, .947 1.00 48. ,96 M 0

ATOM 21875 OWO WAT M 679 24. 795 -66. ,885 -81, .157 1.00 46. 82 M 0

ATOM 21878 OWO WAT M 680 24. 044 2. ,209 -30, ,937 1.00 42. ,71 M 0

ATOM 21881 OWO WAT M 681 46. 209 -53. ,015 -45, .876 1.00 33. ,78 M 0

ATOM 21884 OWO WAT M 682 50. 584 -44. ,354 -41.859 1.00 31. ,07 M 0

ATOM 21887 OWO WAT M 683 15. 148 -18. ,815 -63, ,079 1.00 40. 32 M 0

ATOM 21890 owo WAT M 684 48. 153 -37. ,977 -5, .462 1.00 39. ,95 M 0

ATOM 21893 OWO WAT M 685 43. 529 -70. ,864- -109, .066 1.00 44. ,18 M 0

ATOM 21896 OWO WAT M 686 -12. 728 -17. ,789 -52, .847 1.00 38. ,23 M 0

ATOM 21899 owo WAT M 687 -20. 142 -24. ,800 -77, .260 1.00 32. ,57 M 0

ATOM 21902 OWO WAT M 688 5. 921 -37. ,660 -57, .379 1.00 32. ,62 M 0

ATOM 21905 OWO WAT M 689 -1. 176 -13. ,135 -36, .244 1.00 30. ,51 M 0

ATOM 21908 OWO WAT M 690 -0. 746 -4. ,677 -52, .203 1.00 34. ,78 M 0 cyno fD_Fab

ATOM 21911 OWO WAT M 691 3. .922 -29, .806 -37, .725 1. 00 31, .87 M 0

ATOM 21914 OWO WAT M 692 2, .342 -10, .270 -23, .464 1. ,00 38, .48 M 0

ATOM 21917 OWO WAT M 693 22. .542 -37, .042 -56, .547 1. 00 41, .05 M 0

ATOM 21920 OWO WAT M 694 34. .910 -55, .867 -17, .411 1. 00 49, .07 M 0

ATOM 21923 OWO WAT M 695 13. .890 -28, .735 -37, .148 1. 00 33, .09 M 0

ATOM 21926 OWO WAT M 696 27. ,251 -30, .046 -58, .684 1. 00 34, .81 M 0

ATOM 21929 OWO WAT M 697 36. .882 -26, .949 -36, .537 1. 00 36, .91 M 0

ATOM 21932 OWO WAT M 698 1. ,892 -29, .337 -45, .934 1. 00 22, .82 M 0

ATOM 21935 OWO WAT M 699 -17. ,464 -1, .207 -55, .183 1. 00 27. .37 M 0

ATOM 21938 owo WAT M 700 -1. ,013 -28, .711 -54, .666 1. 00 34. .87 M 0

ATOM 21941 OWO WAT M 701 25. ,729 -32, .891 -37, .422 1. 00 48. .18 M 0

ATOM 21944 owo WAT M 702 60. ,263 -56. .219 -43. .744 1. 00 33. .86 M 0

ATOM 21947 OWO WAT M 703 -12. ,920 10. .746 -76. ,312 1. 00 47. .36 M 0

ATOM 21950 OWO WAT M 704 46. ,925 -35. .206 -63. .315 1. 00 17. ,21 M 0

ATOM 21953 OWO WAT M 705 17. ,453 -7. ,166 -24. .119 1. 00 30. ,97 M 0

ATOM 21956 OWO WAT M 706 36. ,886 -15. ,576 -34. .272 1. 00 31.04 M 0

ATOM 21959 OWO WAT M 707 57. ,586 -50. ,288 -60. ,808 1. 00 25. ,26 M 0

ATOM 21962 OWO WAT M 708 34. ,358 -15. ,982 -34. ,503 1. 00 39. ,20 M 0

ATOM 21965 OWO WAT M 709 54. ,755 -32. ,288 -67. ,318 1. 00 40. ,61 M 0

ATOM 21968 OWO WAT M 710 -4. ,387 -26. ,723 -45. ,137 1. 00 35. ,97 M 0

ATOM 21971 OWO WAT M 711 -20. ,749 2. ,349 -60. ,414 1. 00 39. .68 M 0

ATOM 21974 OWO WAT M 712 27. ,022 -52, ,533 -40. ,504 1. 00 34. ,52 M 0

ATOM 21977 OWO WAT M 713 64. ,748 -64. ,693 -62. ,247 1. 00 39. ,99 M 0

ATOM 21980 OWO WAT M 714 -6. ,071 -19. ,611 -78. ,971 1. 00 46. ,26 M 0

ATOM 21983 OWO WAT M 715 54. ,924 -58. ,627 -89. ,284 1. 00 36. ,41 M 0

ATOM 21986 OWO WAT M 716 59. ,775 -41. ,273 -67. ,407 1. 00 30. ,17 M 0

ATOM 21989 OWO WAT M 717 -8. ,688 -22. ,361 -57. ,341 1. 00 35. ,16 M 0

ATOM 21992 OWO WAT M 718 5. 245 -3. ,116 -28. ,594 1. 00 42. ,41 M 0

ATOM 21995 OWO WAT M 719 51. 058 -55. ,705 -63. ,989 1. 00 25. ,83 M 0

ATOM 21998 OWO WAT M 720 23. 388 -18. ,650 -61. ,155 1. 00 35. ,34 M 0

ATOM 22001 OWO WAT M 721 3. 648 -4. ,753 -58. ,357 1. 00 37. ,00 M 0

ATOM 22004 OWO WAT M 722 32. 426 -61. ,361 -81. ,156 1. 00 50. ,30 M 0

ATOM 22007 OWO WAT M 723 51. 955 -31.585 -51. ,498 1. 00 44. ,97 M 0

ATOM 22010 OWO WAT M 724 32. 422 -18. ,234 -20. ,292 1. 00 43. ,39 M 0

ATOM 22013 OWO WAT M 725 37. 827 -32. ,062 -50. ,333 1. 00 28. ,25 M 0

ATOM 22016 OWO WAT M 726 -18. 103 -0. ,294 -89. ,287 1. 00 42. ,39 M 0

ATOM 22019 OWO WAT M 727 33. 595 -45. ,859 -86. ,332 1. 00 48. ,15 M 0

ATOM 22022 OWO WAT M 728 38. 983 9. ,672 -28. ,984 1. 00 40. ,03 M 0

ATOM 22025 OWO WAT M 729 17. 680 -10. ,006 -60. ,365 1. 00 40. ,57 M 0

ATOM 22028 OWO WAT M 730 6. 674 -28. ,466 -19. ,692 1. 00 41. 65 M 0

ATOM 22031 OWO WAT M 731 -19. 453 -25. ,192 -65. ,498 1. 00 41.34 M 0

ATOM 22034 OWO WAT M 732 23. 218 -34. ,571 -50. ,204 1. 00 39. ,73 M 0

ATOM 22037 OWO WAT M 733 34. 378 -46. ,906 -7. ,851 1. 00 42. ,45 M 0

ATOM 22040 OWO WAT M 734 31. 748 0. ,101 -6. ,654 1. 00 48. ,04 M 0

ATOM 22043 OWO WAT M 735 44. 905 -68. 353 -55. ,921 1. 00 49. ,97 M 0

ATOM 22046 OWO WAT M 736 48. 265 -67. ,318 -97. ,369 1. 00 34. ,18 M 0

ATOM 22049 OWO WAT M 737 16. 966 -36. ,913 -58. ,133 1. 00 28. ,81 M 0

ATOM 22052 OWO WAT M 738 -14. 859 -18. ,321 -87. ,173 1. 00 46. ,91 M 0

ATOM 22055 OWO WAT M 739 51. 974 -25. ,382 -20. ,345 1. 00 49. ,17 M 0

ATOM 22058 OWO WAT M 740 55. 446 -59. ,384 -22. ,995 1. 00 37. 86 M 0

ATOM 22061 OWO WAT M 741 65. 128 -60. ,926 -57. ,253 1. 00 43. 53 M 0

ATOM 22064 OWO WAT M 742 45. 079 -33. ,503 -53. ,965 1. 00 50. ,30 M 0

ATOM 22067 OWO WAT M 743 50. 242 -44. ,293 -99. ,217 1. 00 51. ,56 M 0

ATOM 22070 OWO WAT M 744 -21. 127 -11. ,325 -51.972 1. 00 40. ,76 M 0

ATOM 22073 owo WAT M 745 52. 213 -16. ,771 -22. ,803 1. 00 61. 98 M 0

ATOM 22076 OWO WAT M 746 52. 595 -62. ,102- •101.082 1. 00 43. ,57 M 0

ATOM 22079 OWO WAT M 747 32. 239 -35. ,429 -35. ,182 1. 00 51.23 M 0

ATOM 22082 OWO WAT M 748 62. 992 -63. ,211 -56. ,501 1. 00 41. ,67 M 0

ATOM 22085 OWO WAT M 749 -7. 339 -22. ,246 -32. ,208 1. 00 50. 36 M 0

ATOM 22088 owo WAT M 750 -0. 808 -8. ,784 -88. ,953 1. 00 44. 06 M 0

ATOM 22091 OWO WAT M 751 -21. 203 -8. ,813 -89. ,672 1. 00 45. 63 M 0

ATOM 22094 OWO WAT M 752 45. 649 -36. ,372 -23. ,030 1. 00 42. ,44 M 0

ATOM 22097 owo WAT M 753 46. 788 -26. ,317 -41. ,901 1. 00 40. ,85 M 0

ATOM 22100 OWO WAT M 754 48. 950 -34. ,559 -49. ,015 1. 00 39. 56 M 0

ATOM 22103 OWO WAT M 755 63. 373 -33. ,479 -43. ,706 1. 00 36. ,57 M 0

ATOM 22106 owo WAT M 756 30. 730 -36. ,860 -32. ,965 1. 00 27. ,57 M 0

ATOM 22109 OWO WAT M 757 46. 289 -43. ,113 -76. ,599 1. 00 32. ,10 M 0

ATOM 22112 OWO WAT M 758 54. 388 -30. ,480 -53. ,157 1. 00 30. ,81 M 0 cyno fD_Fab

ATOM 22115 OWO WAT M 759 43. .356 -23, ,340 -47, ,218 1. 00 39. .40 M 0

ATOM 22118 OWO WAT M 760 45. .715 -32. .684 -70, .007 1. 00 27. ,61 M 0

ATOM 22121 OWO WAT M 761 -22. .557 -10. .203 -53. .653 1. 00 39. ,09 M 0

ATOM 22124 OWO WAT M 762 65. ,337 -55. .843 -53. .702 1. 00 37. ,26 M 0

ATOM 22127 OWO WAT M 763 40. .294 -23, ,114 -58. .663 1. 00 39. ,90 M 0

ATOM 22130 OWO WAT M 764 53. ,373 -27. .068 -34. .959 1. 00 40. 35 M 0

ATOM 22133 OWO WAT M 765 28. .400 -53. .712 -48. .283 1. 00 32. ,10 M 0

ATOM 22136 OWO WAT M 766 -3. ,884 -27. .771 -42. ,084 1. 00 26. 03 M 0

ATOM 22139 OWO WAT M 767 52. ,056 -33. ,006 -66. ,187 1. 00 29. ,01 M 0

ATOM 22142 OWO WAT M 768 36. 229 -25. ,960 -59. ,736 1. 00 41. ,91 M 0

ATOM 22145 OWO WAT M 769 20. ,706 -30. ,334 -37. ,784 1. 00 34. 66 M 0

ATOM 22148 owo WAT M 770 61. ,654 -44, ,976 -68. ,888 1. 00 30. ,76 M 0

ATOM 22151 OWO WAT M 771 4. ,448 -38. ,169 -59. ,293 1. 00 27. 82 M 0

ATOM 22154 OWO WAT M 772 -19. ,573 -10. ,767 -89. ,289 1. 00 37. 80 M 0

ATOM 22157 OWO WAT M 773 -21. ,484 4. ,628 -58. ,633 1. 00 35. 60 M 0

ATOM 22160 OWO WAT M 774 48. ,013 -37. ,385 -28. ,624 1. 00 47. 68 M 0

ATOM 22163 OWO WAT M 775 -15. 638 -22. .543 -50. ,591 1. 00 36. ,58 M 0

ATOM 22166 OWO WAT M 776 63. 285 -62. .674 -53. ,815 1. 00 37. 68 M 0

ATOM 22169 OWO WAT M 777 53. 648 -43. ,870 -39. ,244 1. 00 34. 20 M 0

ATOM 22172 OWO WAT M 778 7. 770 -2. ,192 -30. 734 1. 00 41. 71 M 0

ATOM 22175 OWO WAT M 779 21. 452 -36. 791 -59. 817 1. 00 37. 22 M 0

ATOM 22178 OWO WAT M 780 11. 899 -25. 661 -61. 109 1. 00 27. 38 M 0

ATOM 22181 owo WAT M 781 65. 611 -62. ,263 -60. ,299 1. 00 46. 88 M 0

ATOM 22184 OWO WAT M 782 8. 628 -7. 004 -63. 181 1. 00 40. 81 M 0

ATOM 22187 OWO WAT M 783 50. 283 -67. 804 -99. 034 1. 00 39. 81 M 0

ATOM 22190 OWO WAT M 784 -5. 974 -14. 094 -65. 902 1. 00 33. 51 M 0

ATOM 22193 OWO WAT M 785 -4. 442 -19. 990 -70. 765 1. 00 26. 82 M 0

ATOM 22196 OWO WAT M 786 25. 811 -56. ,592 -83. ,676 1. 00 45. 11 M 0

END