Title:
CO-CRYSTALS OF SUBSTITUTED GLYCINE COMPOUNDS AND USES THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/145553
Kind Code:
A1
Abstract:
The present disclosure provides co-crystals of a substituted glycine compound and a co-former compound of Formula (I), compositions comprising such, and uses thereof in treating and/or reducing the risk for a neuropsychiatricdisorder (e.g., schizophrenia, psychotic disorders, depressive disorders, suicidal ideation and/or behavior, obsessive compulsive disorderor Alzheimer's disease). Also provided herein are methods for preparing the co-crystals.
Inventors:
TSAI GUOCHUAN EMIL (US)
WANG CHING-CHENG (CN)
HSIEH TIEN-LAN (CN)
WANG CHING-CHENG (CN)
HSIEH TIEN-LAN (CN)
Application Number:
PCT/CN2018/072186
Publication Date:
August 16, 2018
Filing Date:
January 11, 2018
Export Citation:
Assignee:
SYNEURX INT TAIWAN CORP (CN)
International Classes:
A61K31/198; A61K47/12; A61P25/00; C07C57/15; C07C59/255; C07C229/12; C07D307/62
Domestic Patent References:
| WO2008153945A2 | 2008-12-18 | |||
| WO2016001681A1 | 2016-01-07 | |||
| WO2008153945A2 | 2008-12-18 |
Other References:
FLECK, M. ET AL.: "Two forms of sarcosine sarcosinium hydrogen L-tartrate", JOURNAL OF MOLECULAR STRUCTURE, vol. 1045, 22 April 2013 (2013-04-22), pages 95 - 103, XP028561514
LOSEV, E.A. ET AL.: "Polymorphic transformations in glycine cocrystals at low temperature and high pressure: two new examples as a follow-up to a glycine-glutaric acid study", CRYSTENGCOMM, vol. 18, 20 June 2016 (2016-06-20), pages 5869 - 5875, XP055530241
LOSEV, E. A. ET AL.: "The effect of carboxylic acids on glycine polymorphism, salt and co- crystal formation. A comparison of different crystallisation techniques", NEW J. CHEM., vol. 37, 26 March 2013 (2013-03-26), pages 1973 - 1981, XP055530244
"Handbook of Chemistry and Physics", article "Periodic Table of the Elements"
T. W. GREENEP. G. M. WUTS: "Protecting Groups in Organic Synthesis", 1999, UNIVERSITY SCIENCE BOOKS
SMITHMARCH: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS, INC.
LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS, INC
CARRUTHERS: "Some Modern Methods of Organic Synthesis", 1987, CAMBRIDGE UNIVERSITY PRESS
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 2725 - 19
ELIEL: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
BUNDGARD, H: "Design of Prodrugs", 1985, ELSEVIER, pages: 7 - 9,21-22
"Diagnostic and Statistical Manual of Mental Disorders", 2015, AMERICAN PSYCHIATRIC ASSOCIATION, pages: 1994
BARNES, J COMP PHYSIOL PSYCHOL, vol. 93, no. 1, 1979, pages 74 - 104
See also references of EP 3579828A4
LOSEV, E.A. ET AL.: "Polymorphic transformations in glycine cocrystals at low temperature and high pressure: two new examples as a follow-up to a glycine-glutaric acid study", CRYSTENGCOMM, vol. 18, 20 June 2016 (2016-06-20), pages 5869 - 5875, XP055530241
LOSEV, E. A. ET AL.: "The effect of carboxylic acids on glycine polymorphism, salt and co- crystal formation. A comparison of different crystallisation techniques", NEW J. CHEM., vol. 37, 26 March 2013 (2013-03-26), pages 1973 - 1981, XP055530244
"Handbook of Chemistry and Physics", article "Periodic Table of the Elements"
T. W. GREENEP. G. M. WUTS: "Protecting Groups in Organic Synthesis", 1999, UNIVERSITY SCIENCE BOOKS
SMITHMARCH: "March's Advanced Organic Chemistry", 2001, JOHN WILEY & SONS, INC.
LAROCK: "Comprehensive Organic Transformations", 1989, VCH PUBLISHERS, INC
CARRUTHERS: "Some Modern Methods of Organic Synthesis", 1987, CAMBRIDGE UNIVERSITY PRESS
JACQUES ET AL.: "Enantiomers, Racemates and Resolutions", 1981, WILEY INTERSCIENCE
BERGE ET AL., J. PHARMACEUTICAL SCIENCES, vol. 66, 1977, pages 2725 - 19
ELIEL: "Stereochemistry of Carbon Compounds", 1962, MCGRAW-HILL
WILEN: "Tables of Resolving Agents and Optical Resolutions", 1972, UNIV. OF NOTRE DAME PRESS, pages: 268
BUNDGARD, H: "Design of Prodrugs", 1985, ELSEVIER, pages: 7 - 9,21-22
"Diagnostic and Statistical Manual of Mental Disorders", 2015, AMERICAN PSYCHIATRIC ASSOCIATION, pages: 1994
BARNES, J COMP PHYSIOL PSYCHOL, vol. 93, no. 1, 1979, pages 74 - 104
See also references of EP 3579828A4
Attorney, Agent or Firm:
LIU, SHEN & ASSOCIATES (CN)
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