Title:
COMBINATION OF TYROSINE KINASE INHIBITOR AND HER-2/NEU FOR CANCER THERAPY
Document Type and Number:
WIPO Patent Application WO2006061253
Kind Code:
A3
Abstract:
A method of treating cancer is described comprising administration of a 4quinazolineamine and a vaccine targeting the HER-2/neu molecule, as well as a pharmaceutical combination comprising 4-quinazolineamines and a vaccine targeting the HER-2/neu molecule.
Inventors:
BRUCK CLAUDINE ELVIRE MARIE (US)
GERARD CATHERINE MARIE GHISLAI (BE)
GERARD CATHERINE MARIE GHISLAI (BE)
Application Number:
PCT/EP2005/013409
Publication Date:
November 16, 2006
Filing Date:
December 08, 2005
Export Citation:
Assignee:
GLAXOSMITHKLINE BIOLOG SA (BE)
BRUCK CLAUDINE ELVIRE MARIE (US)
GERARD CATHERINE MARIE GHISLAI (BE)
BRUCK CLAUDINE ELVIRE MARIE (US)
GERARD CATHERINE MARIE GHISLAI (BE)
International Classes:
A61K39/00; A61K31/517; A61P35/00
Domestic Patent References:
| WO1999035146A1 | 1999-07-15 | |||
| WO2002056912A2 | 2002-07-25 | |||
| WO2002002552A1 | 2002-01-10 | |||
| WO2000044899A1 | 2000-08-03 | |||
| WO2005016347A1 | 2005-02-24 | |||
| WO2005011607A2 | 2005-02-10 |
Other References:
HUANG S. ET AL.: "Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR) combining anti-EGFR antibody with tyrosine kinase inhibitor", CANCER RES., vol. 64, 1 August 2004 (2004-08-01), pages 5355 - 5362, XP002391763
ESTEVA F.J.: "Monoclonal antibodies, small molecules and vaccines in the treatment of breast cancer.", THE ONCOLOGIST, vol. 9, no. Suppl.3, 2004, pages 4 - 9, XP002391764
FORMENTO P ET AL: "Dual HER 1-2 targeting of hormone-refractory prostate cancer by ZD1839 and trastuzumab", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 40, no. 18, December 2004 (2004-12-01), pages 2837 - 2844, XP004661413, ISSN: 0959-8049
KO B.K. ET AL.: "Clinical studies of vaccines targeting breast cancer.", CLINICAL CANCER RESEARCH, vol. 9, 15 August 2003 (2003-08-15), pages 3222 - 3234, XP002391765
ESTEVA F.J.: "Monoclonal antibodies, small molecules and vaccines in the treatment of breast cancer.", THE ONCOLOGIST, vol. 9, no. Suppl.3, 2004, pages 4 - 9, XP002391764
FORMENTO P ET AL: "Dual HER 1-2 targeting of hormone-refractory prostate cancer by ZD1839 and trastuzumab", EUROPEAN JOURNAL OF CANCER, PERGAMON PRESS, OXFORD, GB, vol. 40, no. 18, December 2004 (2004-12-01), pages 2837 - 2844, XP004661413, ISSN: 0959-8049
KO B.K. ET AL.: "Clinical studies of vaccines targeting breast cancer.", CLINICAL CANCER RESEARCH, vol. 9, 15 August 2003 (2003-08-15), pages 3222 - 3234, XP002391765
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