Title:
COMPLEMENT FACTOR B INHIBITOR, AND PHARMACEUTICAL COMPOSITION THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/028527
Kind Code:
A1
Abstract:
A piperidine-containing heterocyclic compound represented by formula (I). The compound treats illnesses and diseases related to complement alternative pathway activation by inhibiting/regulating a complement factor B.
Inventors:
LUAN LINBO (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
CHEN YONGKAI (CN)
WANG CHAODONG (CN)
Application Number:
PCT/CN2021/110859
Publication Date:
February 10, 2022
Filing Date:
August 05, 2021
Export Citation:
Assignee:
SHANGHAI MEIYUE BIOTECH DEV CO LTD (CN)
International Classes:
C07D401/14; A61K31/454; A61K31/4545; A61P27/00; A61P37/00; C07D209/02; C07D413/14
Domestic Patent References:
| WO2015038939A2 | 2015-03-19 | |||
| WO2013164802A1 | 2013-11-07 | |||
| WO2013192345A1 | 2013-12-27 | |||
| WO2014143638A1 | 2014-09-18 | |||
| WO2015009616A1 | 2015-01-22 | |||
| WO2015066241A1 | 2015-05-07 | |||
| WO2019043609A1 | 2019-03-07 | |||
| WO2018005552A1 | 2018-01-04 | |||
| WO2015009616A1 | 2015-01-22 |
Foreign References:
| CN109414441A | 2019-03-01 | |||
| CN105579444A | 2016-05-11 | |||
| CN111032042A | 2020-04-17 | |||
| CN202010790872A | 2020-08-07 |
Other References:
MAINOLFI NELLO, EHARA TAKERU, KARKI RAJESHRI G., ANDERSON KAREN, MAC SWEENEY AENGUS, LIAO SHA-MEI, ARGIKAR UPENDRA A., JENDZA KEIT: "Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 63, no. 11, 11 June 2020 (2020-06-11), US , pages 5697 - 5722, XP055791648, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.9b01870
ANNA SCHUBART, KAREN ANDERSON, NELLO MAINOLFI, HOLGER SELLNER, TAKERU EHARA, CHRISTOPHER M. ADAMS, AENGUS MAC SWEENEY, SHA-MEI LIA: "Small-molecule factor B inhibitor for the treatment of complement-mediated diseases", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 16, 16 April 2019 (2019-04-16), pages 7926 - 7931, XP055657593, ISSN: 0027-8424, DOI: 10.1073/pnas.1820892116
MEDICINE (BALTIMORE, vol. 76, no. 2, 1997, pages 63 - 93
FRONTIERS IN IMMUNOLOGY, vol. 10, 2019, pages 1157
JNEPHROL, vol. 26, no. 4, 2013, pages 708 - 715
J CLIN IMMUNOL, vol. 34, no. 2, 2014, pages 224 - 232
EUR J, vol. 17, no. 3, 1987, pages 321 - 326
AM J NEPHROL, vol. 20, no. 2, 2000, pages 122 - 128
IGA NEPHROPATHY, vol. 95, no. 4, 2019, pages 750 - 756
IMMUNITY, vol. 16, 2002, pages 157 - 168
XUAN YUAN ET AL., HAEMATOLOGICA, vol. 102, 2017, pages 466 - 475
ANNA SCHUBART, KAREN ANDERSON, NELLO MAINOLFI, HOLGER SELLNER, TAKERU EHARA, CHRISTOPHER M. ADAMS, AENGUS MAC SWEENEY, SHA-MEI LIA: "Small-molecule factor B inhibitor for the treatment of complement-mediated diseases", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, NATIONAL ACADEMY OF SCIENCES, vol. 116, no. 16, 16 April 2019 (2019-04-16), pages 7926 - 7931, XP055657593, ISSN: 0027-8424, DOI: 10.1073/pnas.1820892116
MEDICINE (BALTIMORE, vol. 76, no. 2, 1997, pages 63 - 93
FRONTIERS IN IMMUNOLOGY, vol. 10, 2019, pages 1157
JNEPHROL, vol. 26, no. 4, 2013, pages 708 - 715
J CLIN IMMUNOL, vol. 34, no. 2, 2014, pages 224 - 232
EUR J, vol. 17, no. 3, 1987, pages 321 - 326
AM J NEPHROL, vol. 20, no. 2, 2000, pages 122 - 128
IGA NEPHROPATHY, vol. 95, no. 4, 2019, pages 750 - 756
IMMUNITY, vol. 16, 2002, pages 157 - 168
XUAN YUAN ET AL., HAEMATOLOGICA, vol. 102, 2017, pages 466 - 475
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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