Title:
COMPLEX OF TELOMERE PROTEIN WITH GUANINE-QUADRUPLEX DNA
Document Type and Number:
WIPO Patent Application WO/2004/069868
Kind Code:
A1
Abstract:
It is intended to provide a complex which is formed by a telomere protein TRF1 or TRF2 or a telomere protein fragment containing the DNA-binding domain thereof and a DNA having the guanine-quadruplex structure in the presence of a cation. Also, it is intended to provide a DNA capable of having the guanine-quadruplex structure. Use of the above-described DNA and complex makes it possible to analyze the mechanisms of aging and canceration and design drugs such as carcinostatic agents.
Inventors:
NISHIMURA YOSHIFUMI (JP)
Application Number:
PCT/JP2004/001220
Publication Date:
August 19, 2004
Filing Date:
February 05, 2004
Export Citation:
Assignee:
CITY OF YOKOHAMA (JP)
NISHIMURA YOSHIFUMI (JP)
NISHIMURA YOSHIFUMI (JP)
International Classes:
C07K14/47; C12N15/11; C12N15/12; (IPC1-7): C07K14/47; C12N15/12
Foreign References:
| JP2003135087A | 2003-05-13 |
Other References:
NISHIKAWA T. ET AL: "Structure of the DNA-binding domain of human telomeric protein, TRF1 and its interaction with telomeric DNA", NUCLEIC ACIDS RES., no. 1, 2001, pages 273 - 274, XP002979537
NISHIKAWA T. ET AL: "Solution structure of a telomeric DNA complex of human TRF1", STRUCTURE, vol. 9, December 2001 (2001-12-01), pages 1237 - 1251, XP002979538
REN J. ET AL: "Tiny telomere DNA", NUCLEIC ACIDS RESEARCH, vol. 30, no. 11, 2002, pages 2307 - 2315, XP002979539
PHAN A.T. ET AL: "Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix", NUCLEIC ACIDS RES., vol. 30, no. 21, 2002, pages 4618 - 4625, XP002979540
PARKINSON G.N. ET AL: "Crystal structure of parallel quadruplexes from human telomeric DNA", NATURE, vol. 417, no. 6891, 20 June 2002 (2002-06-20), pages 876 - 880, XP002979541
NISHIKAWA T. ET AL: "Solution structure of a telomeric DNA complex of human TRF1", STRUCTURE, vol. 9, December 2001 (2001-12-01), pages 1237 - 1251, XP002979538
REN J. ET AL: "Tiny telomere DNA", NUCLEIC ACIDS RESEARCH, vol. 30, no. 11, 2002, pages 2307 - 2315, XP002979539
PHAN A.T. ET AL: "Human telomeric DNA: G-quadruplex, i-motif and Watson-Crick double helix", NUCLEIC ACIDS RES., vol. 30, no. 21, 2002, pages 4618 - 4625, XP002979540
PARKINSON G.N. ET AL: "Crystal structure of parallel quadruplexes from human telomeric DNA", NATURE, vol. 417, no. 6891, 20 June 2002 (2002-06-20), pages 876 - 880, XP002979541
Attorney, Agent or Firm:
Mayama, Setsuko (30-1 Tsuruyacho 3-chome, Kanagawa-ku, Yokohama-sh, Kanagawa 35, JP)
Download PDF: