Title:
COMPOSITION FOR BLOOD PRESSURE DROP, CONTAINING SHIITAKE MUSHROOM MYCELIA CULTURE PRODUCT AND BACILLUS SUBTILIS NATTO CULTURE PRODUCT
Document Type and Number:
WIPO Patent Application WO/2015/178517
Kind Code:
A1
Abstract:
The present invention relates to a composition for blood pressure drop, which is characterized by, particularly, containing a shiitake mushroom mycelia culture product and a Bacillus subtilis natto culture product together. The composition of the present invention can further improve the blood pressure drop effect by thrombolytic ability of the Bacillus subtilis natto culture product even when the content proportion of eritadenine (EA) is low due to the mixing with the Bacillus subtilis natto culture product. Furthermore, the present invention can provide a method for further increasing the content of eritadenine contained in the shiitake mushroom mycelia culture product.
Inventors:
KIM JUNG OK (KR)
Application Number:
PCT/KR2014/004515
Publication Date:
November 26, 2015
Filing Date:
May 21, 2014
Export Citation:
Assignee:
HK BIOTECH CO LTD (KR)
International Classes:
A61K36/07; A61K36/06; A61P9/12
Foreign References:
| KR20100115043A | 2010-10-27 | |||
| JP2006257007A | 2006-09-28 |
Other References:
HAM, SEOK JIN: "Korean Traditional Tea, Good For Health and Mood Improvement", THE HANKYOREH, 22 September 1997 (1997-09-22), pages 11
FUJITA, M. ET AL.: "Antihypertensive effects of continuous oral administration of nattokinas and its fragments in spontaneously hypertensive rats", BIOL. PHARM. BULL., vol. 34, no. 11, 2011, pages 1696 - 1701, XP055238593
OH, Y.-S. ET AL.: "Physiological activity of tofu fermented with mushroom mycelia", FOOD CHEMISTRY, vol. 133, 2012, pages 728 - 734, XP028468298
ENMAN, J. ET AL.: "Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 56, 2008, pages 2609 - 2612, XP003024011
FUJITA, M. ET AL.: "Antihypertensive effects of continuous oral administration of nattokinas and its fragments in spontaneously hypertensive rats", BIOL. PHARM. BULL., vol. 34, no. 11, 2011, pages 1696 - 1701, XP055238593
OH, Y.-S. ET AL.: "Physiological activity of tofu fermented with mushroom mycelia", FOOD CHEMISTRY, vol. 133, 2012, pages 728 - 734, XP028468298
ENMAN, J. ET AL.: "Production of the bioactive compound eritadenine by submerged cultivation of shiitake (Lentinus edodes) mycelia", JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 56, 2008, pages 2609 - 2612, XP003024011
Attorney, Agent or Firm:
JIN, Cheon Woong et al. (KR)
진천웅 (KR)
진천웅 (KR)
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