Title:
COMPOSITION COMPRISING ALOX5 INHIBITOR FOR PREVENTING OR TREATING SARCOPENIA
Document Type and Number:
WIPO Patent Application WO/2023/177128
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising an Alox5 inhibitor for preventing or treating sarcopenia, and comprises a material that targets Alox5 so as to inhibit the expression or activation thereof, and thus improves muscular performance, increases muscle mass and cross-sectional areas of muscle fibers, and reduces the expression of myoatrophy regulators, thereby effectively preventing, alleviating and treating sarcopenia.
Inventors:
DARREN WILLIAMS (KR)
JUNG DA WOON (KR)
KIM HYUN JUN (KR)
JUNG DA WOON (KR)
KIM HYUN JUN (KR)
Application Number:
PCT/KR2023/002932
Publication Date:
September 21, 2023
Filing Date:
March 03, 2023
Export Citation:
Assignee:
PLUTO INC (KR)
International Classes:
A61K31/385; A23L33/10; A23L33/13; A61K31/713; A61P21/00
Foreign References:
| KR20200143710A | 2020-12-24 | |||
| KR20070089926A | 2007-09-04 | |||
| KR20180059390A | 2018-06-04 |
Other References:
GOLDMAN STEPHEN M.; JANAKIRAM NAVEENA BASA; VALERIO MICHAEL S.; DEARTH CHRISTOPHER L.: "Evaluation of licofelone as an adjunct anti-inflammatory therapy to biologic scaffolds in the treatment of volumetric muscle loss", CELL AND TISSUE RESEARCH, SPRINGER, DE, vol. 385, no. 1, 14 April 2021 (2021-04-14), DE , pages 149 - 159, XP037503766, ISSN: 0302-766X, DOI: 10.1007/s00441-021-03449-0
KWAK HYUN JEONG, CHOI HYE-EUN, CHEON HYAE GYEONG: "5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes", SCIENTIFIC REPORTS, vol. 7, no. 1, 10 July 2017 (2017-07-10), pages 5025, XP093093050, DOI: 10.1038/s41598-017-05346-5
KWAK HYUN JEONG, CHOI HYE-EUN, CHEON HYAE GYEONG: "5-LO inhibition ameliorates palmitic acid-induced ER stress, oxidative stress and insulin resistance via AMPK activation in murine myotubes", SCIENTIFIC REPORTS, vol. 7, no. 1, 10 July 2017 (2017-07-10), pages 5025, XP093093050, DOI: 10.1038/s41598-017-05346-5
Attorney, Agent or Firm:
JIDAM IP LAW FIRM (KR)
Download PDF: