Title:
COMPOSITION, COMPRISING DNA FRAGMENT MIXTURE AND MATRIX METALLOPROTEASE PRODUCTION INHIBITOR, FOR PREVENTION AND TREATMENT OF ARTHRITIS
Document Type and Number:
WIPO Patent Application WO/2019/240323
Kind Code:
A1
Abstract:
The present invention relates to a composition for prevention and treatment of arthritis, which comprises a DNA fragment mixture and a matrix metalloprotease (MMP) production inhibitor able to solve the problem of matrix metalloprotease production caused upon the use of the DNA fragment mixture in preventing and treating arthritis and thus can suppress inflammatory pain and regenerate cartilage. Being able to inhibit the matrix metalloprotease production attributed to a DNA fragment mixture, the composition can be effectively used to induce a proliferative effect on chondrocytes, a restorative potential from damaged chondrocytes, a regenerative effect on cartilage, and an alleviative effect on arthritis, without side effects.
Inventors:
KIM SEOK-SOON (KR)
Application Number:
PCT/KR2018/008001
Publication Date:
December 19, 2019
Filing Date:
July 16, 2018
Export Citation:
Assignee:
BR PHARM CO LTD (KR)
International Classes:
A61K31/198; A61K31/711; A61K31/7008; A61K31/737; A61P19/02; A61P29/00
Domestic Patent References:
| WO2010049898A1 | 2010-05-06 |
Foreign References:
| KR20080079038A | 2008-08-29 | |||
| KR20100121484A | 2010-11-17 | |||
| KR20130140715A | 2013-12-24 | |||
| KR20170100231A | 2017-09-04 | |||
| KR20130044195A | 2013-05-02 | |||
| KR20170100236A | 2017-09-04 |
Other References:
RODRIGUEZ-SALVADOR, J. ET AL.: "Effect of sodium butyrate on pro-matrix metalloproteinase-9 and -2 differential secretion in pediatric tumors and cell lines", JOURNAL OF EXPERIMENTAL AND CLINICAL CANCER RESEARCH, vol. 24, no. 3, 1 January 2005 (2005-01-01), pages 463 - 473, XP055683304
"Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair", LIFE SCIENCES, vol. 73, 2003, pages 1973 - 1983
"Protective effects of polydeoxyribonucleotides on cartilage degradation in experimental cultures", CELL BIOCHEM FUNCT, vol. 31, 2013, pages 214 - 227
See also references of EP 3607953A4
"Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: A new proposal for bone tissue repair", LIFE SCIENCES, vol. 73, 2003, pages 1973 - 1983
"Protective effects of polydeoxyribonucleotides on cartilage degradation in experimental cultures", CELL BIOCHEM FUNCT, vol. 31, 2013, pages 214 - 227
See also references of EP 3607953A4
Attorney, Agent or Firm:
LEE, Sang-moon et al. (KR)
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