Title:
COMPOSITION COMPRISING PD-L1 ANTIGEN-BINDING FRAGMENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/040999
Kind Code:
A1
Abstract:
A composition comprising an antigen-binding fragment and an excipient, the antigen-binding fragment comprising an immunoglobulin single variable domain capable of specifically binding to PD-L1, the immunoglobulin single variable domain comprising CDR1-3, the CDR3 comprising an amino acid sequence shown in SEQ ID NO: 47, and the excipient possibly comprising proline. The described composition has good stability and suitable viscosity, and can be used for subcutaneous injection.
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Inventors:
XU TING (CN)
GUO KANGPING (CN)
YUN LIHONG (CN)
WU YUANLI (CN)
HUANG YAN (CN)
HU HONGQIN (CN)
GUO KANGPING (CN)
YUN LIHONG (CN)
WU YUANLI (CN)
HUANG YAN (CN)
HU HONGQIN (CN)
Application Number:
PCT/CN2022/119187
Publication Date:
March 23, 2023
Filing Date:
September 16, 2022
Export Citation:
Assignee:
JIANGSU ALPHAMAB BIOPHARMACEUTICALS CO LTD (CN)
SUZHOU ALPHAMAB CO LTD (CN)
SUZHOU ALPHAMAB CO LTD (CN)
International Classes:
C07K16/28; A61K39/395; A61P35/00; A61P37/02
Domestic Patent References:
| WO2017020802A1 | 2017-02-09 | |||
| WO2021083271A1 | 2021-05-06 | |||
| WO2021143767A1 | 2021-07-22 | |||
| WO2021168100A1 | 2021-08-26 | |||
| WO2018211517A1 | 2018-11-22 | |||
| WO2017020802A1 | 2017-02-09 |
Foreign References:
| CN109966487A | 2019-07-05 | |||
| CN111228479A | 2020-06-05 | |||
| US20190060241A1 | 2019-02-28 | |||
| CN112390888A | 2021-02-23 |
Other References:
HUNG JESSICA J.; DEAR BARTON J.; DININ AILEEN K.; BORWANKAR AMEYA U.; MEHTA SUMARTH K.; TRUSKETT THOMAS T.; JOHNSTON KEITH P.: "Improving Viscosity and Stability of a Highly Concentrated Monoclonal Antibody Solution with Concentrated Proline", ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, SPRINGER BERLIN HEIDELBERG, BERLIN/HEIDELBERG, vol. 35, no. 7, 30 April 2018 (2018-04-30), Berlin/Heidelberg, pages 1 - 14, XP036517034, ISSN: 0724-8741, DOI: 10.1007/s11095-018-2398-1
STRICKLEY ROBERT G., LAMBERT WILLIAM J.: "A review of formulations of commercially available antibodies", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 110, no. 7, 1 July 2021 (2021-07-01), US , pages 2590 - 2608.e56, XP055799313, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2021.03.017
WARD ET AL., NATURE, vol. 341, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC.NATL.ACAD.SCI., vol. 85, 1988, pages 5879 - 5883
KANG XIAOZHEN ET AL., CHINESE JOURNAL OF BIOTECHNOLOGY., vol. 34, no. 12, 2018, pages 1974 - 1984
"NCBI", Database accession no. NP 054862.1
"General Rules", CHINESE PHARMACOPOEIA, vol. III, 2015, pages 0731
STRICKLEY ROBERT G., LAMBERT WILLIAM J.: "A review of formulations of commercially available antibodies", JOURNAL OF PHARMACEUTICAL SCIENCES, AMERICAN CHEMICAL SOCIETY AND AMERICAN PHARMACEUTICAL ASSOCIATION, US, vol. 110, no. 7, 1 July 2021 (2021-07-01), US , pages 2590 - 2608.e56, XP055799313, ISSN: 0022-3549, DOI: 10.1016/j.xphs.2021.03.017
WARD ET AL., NATURE, vol. 341, pages 544 - 546
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC.NATL.ACAD.SCI., vol. 85, 1988, pages 5879 - 5883
KANG XIAOZHEN ET AL., CHINESE JOURNAL OF BIOTECHNOLOGY., vol. 34, no. 12, 2018, pages 1974 - 1984
"NCBI", Database accession no. NP 054862.1
"General Rules", CHINESE PHARMACOPOEIA, vol. III, 2015, pages 0731
Attorney, Agent or Firm:
SHANGHAI DIANSHI PARTNERS, P.C. (CN)
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