Title:
COMPOSITION COMPRISING VGLL1 PEPTIDE FOR TREATMENT OF CANCER
Document Type and Number:
WIPO Patent Application WO/2021/194186
Kind Code:
A1
Abstract:
The present invention relates to a peptide fragment for treatment of cancer, a variant thereof, and a use thereof. A peptide fragment of VGLL1 and/or a variant thereof according to the present invention inhibits the proliferation and invasion of cancer cells, thereby exhibiting an excellent effect on the prevention and treatment of cancer.
Inventors:
WON MI SUN (KR)
KIM BO KYUNG (KR)
IM JOO-YOUNG (KR)
KIM DA MI (KR)
KIM BO KYUNG (KR)
IM JOO-YOUNG (KR)
KIM DA MI (KR)
Application Number:
PCT/KR2021/003496
Publication Date:
September 30, 2021
Filing Date:
March 22, 2021
Export Citation:
Assignee:
ONECUREGEN CO LTD (KR)
International Classes:
C07K14/47; A61K38/08; A61K38/10; A61P35/00; C07K7/06
Foreign References:
| KR20190057130A | 2019-05-27 | |||
| KR101714649B1 | 2017-03-10 | |||
| US9527895B2 | 2016-12-27 |
Other References:
KIM BO-KYUNG, CHEONG JAE-HO, IM JOO-YOUNG, BAN HYUN SEUNG, KIM SEON-KYU, KANG MI-JUNG, LEE JUNGWOON, KIM SEON-YOUNG, PARK KYUNG-CH: "PI3K/AKT/β-Catenin Signaling Regulates Vestigial-Like 1 Which Predicts Poor Prognosis and Enhances Malignant Phenotype in Gastric Cancer", CANCERS, vol. 11, no. 12, 3 December 2019 (2019-12-03), pages 1923, XP055852725, DOI: 10.3390/cancers11121923
JIAO SHI; WANG HUIZHEN; SHI ZHUBING; DONG AIMEI; ZHANG WENJING; SONG XIAOMIN; HE FENG; WANG YICUI; ZHANG ZHENZHEN; WANG WENJIA; WA: "A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer", CANCER CELL, CELL PRESS, US, vol. 25, no. 2, 10 February 2014 (2014-02-10), US, pages 166 - 180, XP028610274, ISSN: 1535-6108, DOI: 10.1016/j.ccr.2014.01.010
IM JOO-YOUNG; KIM DA-MI; PARK HYUNKYUNG; KANG MI-JUNG; KIM DA-YOON; CHANG KWAN YOUNG; KIM BO-KYUNG; WON MISUN: "VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-β/ERK/RSK2 signaling", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 1868, no. 1, 16 October 2020 (2020-10-16), NL, XP086349123, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2020.118892
"Remington: The Science and Practice of Pharmacy", 2005, LIPPENCOTT WILLIAMS & WILKINS
JIAO SHI; WANG HUIZHEN; SHI ZHUBING; DONG AIMEI; ZHANG WENJING; SONG XIAOMIN; HE FENG; WANG YICUI; ZHANG ZHENZHEN; WANG WENJIA; WA: "A Peptide Mimicking VGLL4 Function Acts as a YAP Antagonist Therapy against Gastric Cancer", CANCER CELL, CELL PRESS, US, vol. 25, no. 2, 10 February 2014 (2014-02-10), US, pages 166 - 180, XP028610274, ISSN: 1535-6108, DOI: 10.1016/j.ccr.2014.01.010
IM JOO-YOUNG; KIM DA-MI; PARK HYUNKYUNG; KANG MI-JUNG; KIM DA-YOON; CHANG KWAN YOUNG; KIM BO-KYUNG; WON MISUN: "VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-β/ERK/RSK2 signaling", BIOCHIMICA ET BIOPHYSICA ACTA, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM., NL, vol. 1868, no. 1, 16 October 2020 (2020-10-16), NL, XP086349123, ISSN: 0167-4889, DOI: 10.1016/j.bbamcr.2020.118892
"Remington: The Science and Practice of Pharmacy", 2005, LIPPENCOTT WILLIAMS & WILKINS
Attorney, Agent or Firm:
SHIM, Kyoung-Shik et al. (KR)
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