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Title:
COMPOSITION CONTAINING SQUALENE FOR IMPROVING MUSCLE FUNCTION AND PREVENTING MUSCLE DAMAGE
Document Type and Number:
WIPO Patent Application WO/2018/026211
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, treating, improving a muscle disease or regenerating muscle damage, containing squalene. More specifically, the squalene of the present invention increases the expression of proteins involved in muscle protein synthesis and muscle mass increase in muscle cells, inhibits an expression of enzymes involved in myoprotein degradation at the level of mRNA, and has an effect of restoring the recovery of damaged muscle quickly. Also, the present invention is a natural product so as to be safely used without side effects, and thus can be used as medicine, food, or cosmetics.

Inventors:
HWANG, Jae Kwan (#136-2501, 270 Sinbanpo-ro,,Seocho-gu, Seoul, 06544, KR)
LEE, Se In (#707-1101, 516 Gaepo-ro,,Gangnam-gu, Seoul, 06330, KR)
KIM, Mi Bo (#401, 21 Dobong-ro 154ga-gil,,Dobong-gu, Seoul, 01328, KR)
KIM, Chang hee (#103-203, 26 Sinwon-ro,,Gwanak-gu, Seoul, 08775, KR)
Application Number:
KR2017/008397
Publication Date:
February 08, 2018
Filing Date:
August 03, 2017
Export Citation:
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Assignee:
AAT COSTECH CO., LTD. (#114-A, 50 Yonsei-ro,,Seodaemun-gu, Seoul, 03722, KR)
International Classes:
A61K31/01; A23L33/10; A23L33/105; A61K8/31; A61K8/98; A61K35/60; A61K36/63; A61K36/899; A61Q19/00
Foreign References:
KR100526164B12005-10-27
Other References:
NAVER BLOG: "SQUALENE] LOTTE DUTY FREE Australian Health Food Proudex EFO Pure Nature", 2015, pages 1 - 13, Retrieved from the Internet
NAVER CAFE, SQUALENE, 2010, pages 1 - 2, Retrieved from the Internet
NAVER BLOG, SQUALENE, 2007, Retrieved from the Internet
SANCHEZ-FIDALGO, S. ET AL.: "Dietary Squalene Supplementation Improves DSS-induced Acute Colitis by Downregulating p38 MAPK and NFkB Signaling Pathways", MOLECULAR NUTRITION & FOOD RESEARCH, vol. 59, no. 2, February 2015 (2015-02-01), pages 284 - 292, XP055460968
RAO, C. V. ET AL.: "Chemopreventive Effect of Squalene on Colon Cancer", CARCINOGENESIS, vol. 19, no. 2, 1998, pages 287 - 290
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (3rd Floor, 108 Sapyeong-daero,,Seocho-gu, Seoul, 06575, KR)
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