Title:
COMPOSITION FOR DETECTING HYDROGEN SULFIDE OR MEASURING HYDROGEN SULFIDE CONCENTRATION AND COMPOSITION COMPRISING SAME AS EFFECTIVE INGREDIENT FOR DIAGNOSING OR IMAGING IN VIVO INFLAMMATION, TISSUES HAVING HYPOXIC DAMAGE, OR CANCER
Document Type and Number:
WIPO Patent Application WO/2020/055175
Kind Code:
A1
Abstract:
The present invention relates to a composition for detecting hydrogen sulfide or measuring a concentration of hydrogen sulfide, and a composition comprising same as an effective ingredient for diagnosing or imaging in vivo inflammation, tissues having hypoxic damage, or cancer. The composition for detecting hydrogen sulfide or measuring a concentration of hydrogen sulfide according to the present invention, which comprises the compound represented by chemical formula 1 (99mTc-alpha-hydroxy acid) having alpha-hydroxy acid labeled with 99mTc, enables the detection or concentration measurement of hydrogen sulfide in in-vitro and in-vivo levels and, as such, can be advantageously used for detecting hydrogen sulfide and measuring a concentration of hydrogen sulfide and furthermore for discovering biological roles of hydrogen sulfide in vivo, especially, for detecting, imaging, and quantitatively measuring hydrogen sulfide in a disease selected from the group consisting of angiogenesis, inflammation, cancer, Alzheimer's disease, cardiovascular ischemia, and cerebrovascular ischemia, or in hypoxic tissues.
Inventors:
JEONG JAE MIN (KR)
KIM YOUNG JU (KR)
LEE YUN-SANG (KR)
PARK JI YONG (KR)
KIM YOUNG JU (KR)
LEE YUN-SANG (KR)
PARK JI YONG (KR)
Application Number:
PCT/KR2019/011848
Publication Date:
March 19, 2020
Filing Date:
September 11, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K51/02; A61K51/04
Foreign References:
| KR20150116421A | 2015-10-15 | |||
| KR20170018121A | 2017-02-16 |
Other References:
LELE RAMCHANDRAD: "Tc-99m glucoheptonate is poor man's fluorodeoxyglucose", INDIAN JOURNAL OF NUCLEAR MEDICINE, vol. 26, no. 4, 2011, pages 165 - 170, XP055791270, ISSN: 0972-3919, DOI: 10.4103/0972-3919.106678
ANONYMOUS: "Technetium-99m radiopharmaceuticals: manufacture of kits", 2008, pages 1 - 202, XP055693557, Retrieved from the Internet [retrieved on 20191219]
GERALD JOHNSON ; CHRISTINE C. OKADA ; SONIA D. HOCHERMAN ; ZHONGLIN LIU ; CURTIS HART ; BAN-AN KHAW ; ROBERT D. OKADA: "99mTc-glucarate imaging for the early detection of infarct in partially reperfused canine myocardium", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 33, no. 3, 1 March 2006 (2006-03-01), pages 319 - 328, XP019333021, ISSN: 1619-7089, DOI: 10.1007/s00259-005-1913-x
W. HAUSER, H. L. ATKINS, P. RICHARDS: "Lymph node scanning with 99mTc-sulfur colloid", RADIOLOGY, vol. 92, no. 6, 1 May 1969 (1969-05-01), pages 1369 - 1371, XP009526687, ISSN: 0033-8419, DOI: 10.1148/92.6.1369
JAE MIN JEONG, JI YONG PARK, HO YOUNG KIM , YUN-SANG LEE: "Imaging of endogenous hydrogen sulfide using [99mTc] gluconate", THE JOURNAL OF NUCLEAR MEDICINE, vol. 60, no. S1, 1 May 2019 (2019-05-01), pages 1082, XP009526697, ISSN: 0161-5505
KR OLSON ET AL., NITRIC OXIDE, vol. 41, 2014, pages 11 - 26
MD HAMMERS ET AL., J AM CHEM SOC, vol. 137, 2015, pages 10216 - 10223
Y CHEN ET AL., ANGEW CHEM INT ED, vol. 52, 2013, pages 1688 - 1691
AR LIPPERT ET AL., J AM CHEM SOC, vol. 133, 2011, pages 10078 - 10080
N KUMAR ET AL., COORD CHEM REV, vol. 257, 2013, pages 2335 - 2347
J CAO ET AL., CHEM SCI, vol. 6, 2015, pages 1979 - 1985
S SARKAR ET AL., ANGEW CHEM INT ED, vol. 55, 2016, pages 9365 - 9370
LI LBHATIA MZHU YZ ET AL., FASEB J, vol. 19, 2005, pages 1196 - 1198
BHATIA MSIDHAPURIWALA JMOOCHHALA SM ET AL., BR J PHARMACOL, vol. 145, 2005, pages 141 - 144
AD ANGA KONIGSTORFERGI GILESM BHATIA, ADV BIOL CHEM, vol. 2, 2012, pages 360 - 365
REN CDU ALI D ET AL., BRAIN RES, vol. 1345, 2010, pages 197 - 205
KOIZUMI JYOSHIDA YNAKAZAWA T ET AL., JPN J STROKE, vol. 8, 1986, pages 1 - 8
See also references of EP 3851127A4
ANONYMOUS: "Technetium-99m radiopharmaceuticals: manufacture of kits", 2008, pages 1 - 202, XP055693557, Retrieved from the Internet
GERALD JOHNSON ; CHRISTINE C. OKADA ; SONIA D. HOCHERMAN ; ZHONGLIN LIU ; CURTIS HART ; BAN-AN KHAW ; ROBERT D. OKADA: "99mTc-glucarate imaging for the early detection of infarct in partially reperfused canine myocardium", EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, vol. 33, no. 3, 1 March 2006 (2006-03-01), pages 319 - 328, XP019333021, ISSN: 1619-7089, DOI: 10.1007/s00259-005-1913-x
W. HAUSER, H. L. ATKINS, P. RICHARDS: "Lymph node scanning with 99mTc-sulfur colloid", RADIOLOGY, vol. 92, no. 6, 1 May 1969 (1969-05-01), pages 1369 - 1371, XP009526687, ISSN: 0033-8419, DOI: 10.1148/92.6.1369
JAE MIN JEONG, JI YONG PARK, HO YOUNG KIM , YUN-SANG LEE: "Imaging of endogenous hydrogen sulfide using [99mTc] gluconate", THE JOURNAL OF NUCLEAR MEDICINE, vol. 60, no. S1, 1 May 2019 (2019-05-01), pages 1082, XP009526697, ISSN: 0161-5505
KR OLSON ET AL., NITRIC OXIDE, vol. 41, 2014, pages 11 - 26
MD HAMMERS ET AL., J AM CHEM SOC, vol. 137, 2015, pages 10216 - 10223
Y CHEN ET AL., ANGEW CHEM INT ED, vol. 52, 2013, pages 1688 - 1691
AR LIPPERT ET AL., J AM CHEM SOC, vol. 133, 2011, pages 10078 - 10080
N KUMAR ET AL., COORD CHEM REV, vol. 257, 2013, pages 2335 - 2347
J CAO ET AL., CHEM SCI, vol. 6, 2015, pages 1979 - 1985
S SARKAR ET AL., ANGEW CHEM INT ED, vol. 55, 2016, pages 9365 - 9370
LI LBHATIA MZHU YZ ET AL., FASEB J, vol. 19, 2005, pages 1196 - 1198
BHATIA MSIDHAPURIWALA JMOOCHHALA SM ET AL., BR J PHARMACOL, vol. 145, 2005, pages 141 - 144
AD ANGA KONIGSTORFERGI GILESM BHATIA, ADV BIOL CHEM, vol. 2, 2012, pages 360 - 365
REN CDU ALI D ET AL., BRAIN RES, vol. 1345, 2010, pages 197 - 205
KOIZUMI JYOSHIDA YNAKAZAWA T ET AL., JPN J STROKE, vol. 8, 1986, pages 1 - 8
See also references of EP 3851127A4
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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