Title:
COMPOSITION FOR DIAGNOSING DISEASES ASSOCIATED WITH COX2 OVEREXPRESSION AND SCREENING METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/235824
Kind Code:
A1
Abstract:
The present invention relates to a composition for diagnosing diseases associated with cyclooxygenase 2 (COX2) overexpression and a screening method therefor and, more particularly, to: a composition for diagnosing diseases associated with COX2 overexpression, containing a compound with a structural feature of exhibiting strong binding activity to a COX2 protein; and a screening method therefor.
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Inventors:
BAE JAE-SUNG (KR)
JIN HEE KYUNG (KR)
LEE JU YOUN (KR)
HAN SEUNG HOON (KR)
JIN HEE KYUNG (KR)
LEE JU YOUN (KR)
HAN SEUNG HOON (KR)
Application Number:
PCT/KR2019/006751
Publication Date:
December 12, 2019
Filing Date:
June 04, 2019
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND (KR)
International Classes:
A61K51/04; G01N33/68; G01N33/60
Foreign References:
| KR19990064310A | 1999-07-26 | |||
| KR20180066312A | 2018-06-19 |
Other References:
LEE, J. Y. ET AL.: "Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's disease", NATURE COMMUNICATIONS, vol. 9, no. 1479, 16 April 2018 (2018-04-16), pages 1 - 14, XP055636239
DATABASE NCBI 21 December 1994 (1994-12-21), Database accession no. AAA.57317.1
NEKKAZ, K. ET AL.: "Docking Studies on Cyclooxygenases-2 Inhibitors based on Potential Ligand Binding Sites", INTERNATIONAL JOURNAL OF COMPUTER APPLICATIONS, vol. 87, no. 1, 2014, pages 27 - 34, XP055661963
AMARAVANI, M. ET AL.: "COX-2 structural analysis and docking studies with gallic acid structural analogues", SPRINGERPLUS, vol. 1, no. 58, 2012, pages 1 - 7, XP055661964
PNAS, vol. 100, no. 9, 29 April 2003 (2003-04-29), pages 5473 - 5478
EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 18, 2003, pages 1527 - 1534
JOURNAL OF NEUROTRAUMA, vol. 17, no. 8, 2000, pages 695 - 711
PNAS, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1294 - 1299
"GeneBank", Database accession no. AAR23927.1
NAT COMMUN., vol. 9, no. 1, 9 January 2018 (2018-01-09), pages 128
NAT COMMUN., vol. 9, no. 1, 16 April 2018 (2018-04-16), pages 1479
CURR NEUROPHARMACOL, vol. 8, no. 1, March 2010 (2010-03-01), pages 62 - 68
J CELL PHYSIOL., vol. 234, no. 5, May 2019 (2019-05-01), pages 5683 - 5699
See also references of EP 3805761A4
DATABASE NCBI 21 December 1994 (1994-12-21), Database accession no. AAA.57317.1
NEKKAZ, K. ET AL.: "Docking Studies on Cyclooxygenases-2 Inhibitors based on Potential Ligand Binding Sites", INTERNATIONAL JOURNAL OF COMPUTER APPLICATIONS, vol. 87, no. 1, 2014, pages 27 - 34, XP055661963
AMARAVANI, M. ET AL.: "COX-2 structural analysis and docking studies with gallic acid structural analogues", SPRINGERPLUS, vol. 1, no. 58, 2012, pages 1 - 7, XP055661964
PNAS, vol. 100, no. 9, 29 April 2003 (2003-04-29), pages 5473 - 5478
EUROPEAN JOURNAL OF NEUROSCIENCE, vol. 18, 2003, pages 1527 - 1534
JOURNAL OF NEUROTRAUMA, vol. 17, no. 8, 2000, pages 695 - 711
PNAS, vol. 98, no. 3, 30 January 2001 (2001-01-30), pages 1294 - 1299
"GeneBank", Database accession no. AAR23927.1
NAT COMMUN., vol. 9, no. 1, 9 January 2018 (2018-01-09), pages 128
NAT COMMUN., vol. 9, no. 1, 16 April 2018 (2018-04-16), pages 1479
CURR NEUROPHARMACOL, vol. 8, no. 1, March 2010 (2010-03-01), pages 62 - 68
J CELL PHYSIOL., vol. 234, no. 5, May 2019 (2019-05-01), pages 5683 - 5699
See also references of EP 3805761A4
Attorney, Agent or Firm:
LEE, Hee Sook (KR)
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