Title:
COMPOSITION HAVING TISSUE REPAIRING ACTIVITY AND UTILIZATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2014/098249
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition having a tissue repairing activity that is capable of promoting a reaction relating to tissue repairing. Disclosed is a composition having an activity of repairing a tissue, said composition comprising at least one component selected from the group consisting of: a first component that is a protein having a monocyte chemotactic protein-1 (MCP-1) activity; a second component that is a protein having the extracellular domain activity of sialic acid-binding immunoglobulin-type lectin-9 (Siglec-9); and a third component that is chondroitin sulfate or chondroitin sulfate proteoglycan.
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Inventors:
YAMAMOTO AKIHITO (JP)
UEDA MINORU (JP)
MATSUBARA KOHKI (JP)
SUZUMURA AKIO (JP)
FURUKAWA KOICHI (JP)
MATSUSHITA YOSHIHIRO (JP)
WAKAYAMA HIROTAKA (JP)
TAKAHASHI NOBUNORI (JP)
TSUNEKAWA SHIN (JP)
IZUMOTO TAKAKO (JP)
UEDA MINORU (JP)
MATSUBARA KOHKI (JP)
SUZUMURA AKIO (JP)
FURUKAWA KOICHI (JP)
MATSUSHITA YOSHIHIRO (JP)
WAKAYAMA HIROTAKA (JP)
TAKAHASHI NOBUNORI (JP)
TSUNEKAWA SHIN (JP)
IZUMOTO TAKAKO (JP)
Application Number:
PCT/JP2013/084523
Publication Date:
June 26, 2014
Filing Date:
December 24, 2013
Export Citation:
Assignee:
UNIV NAGOYA NAT UNIV CORP (JP)
International Classes:
A61K31/737; A61K38/00; A61K45/00; A61K45/06; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P11/00; A61P17/02; A61P19/02; A61P21/00; A61P25/00; A61P25/16; A61P25/28; A61P27/04; A61P29/00; A61P37/02; A61P37/06; A61P43/00; C12N15/09
Domestic Patent References:
| WO2011118795A1 | 2011-09-29 | |||
| WO2011118795A1 | 2011-09-29 |
Other References:
TOMOJI ANDO ET AL.: "Jiko Soshiki Shinsei Saisei ni Okeru CCR2 Izongata - Seitainai Kansaibo Shuseki no Yakuwari", REGENERATIVE MEDICINE, vol. 10, 2011, XP008181710
SZYMCZAK WA ET AL.: "The CCL7-CCL2-CCR2 axis regulates IL -4 production in lungs and fungal immunity", J IMMUNOL, vol. 183, no. 3, 2009, pages 1964 - 1974, XP055266565
MUZZARELLI R A.A ET AL.: "Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration", A REVIEW, CARBOHYDRATE POLYMERS, vol. 89, no. 3, July 2012 (2012-07-01), pages 723 - 739, XP055266574
ICHIRO TSUJI: "Physical Properties and Tissue Response of Canal Sealer Pastes Containing Tetracalcium Phosphate-Chondroitin Sulfate A", NIHON SHIKA HOZONGAKU ZASSHI, vol. 36, no. 3, 1993, pages 31 - 32, XP008179985
"Introduction to the Glycoscience Dai 5 Kai -Saibogai Matrix 2- Kenko na Karada o Sasaeru Urakata - Chondroitin Ryusan", 2007, XP055267080, Retrieved from the Internet
ZHANG JQ ET AL.: "Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes", J BIOL CHEM, vol. 275, no. 29, 2000, pages 22121 - 22126, XP002909451
ANDO Y ET AL.: "Stem cell -conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms", BONE, vol. 61, 2014, pages 82 - 90, XP028667601
DAVID, S.; KRONER, A., NATURE REVIEWS NEUROSCIENCE, vol. 12, no. 7, pages 388 - 399
POPOVICH, P.G.; LONGBRAKE, E.E., NATURE REVIEWS NEUROSCIENCE, vol. 9, no. 6, pages 481 - 493
ALTSCHUL SF; GISH W; MILLER W; MYERS EW; LIPMAN DJ., J. MOL. BID., vol. 215, 1990, pages 403 - 410
ALTSCHUL SF; MADDEN TL; SCHAFFER AA; ZHANG J; MILLER W; LIPMAN DJ., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
See also references of EP 2937088A4
SZYMCZAK WA ET AL.: "The CCL7-CCL2-CCR2 axis regulates IL -4 production in lungs and fungal immunity", J IMMUNOL, vol. 183, no. 3, 2009, pages 1964 - 1974, XP055266565
MUZZARELLI R A.A ET AL.: "Chitosan, hyaluronan and chondroitin sulfate in tissue engineering for cartilage regeneration", A REVIEW, CARBOHYDRATE POLYMERS, vol. 89, no. 3, July 2012 (2012-07-01), pages 723 - 739, XP055266574
ICHIRO TSUJI: "Physical Properties and Tissue Response of Canal Sealer Pastes Containing Tetracalcium Phosphate-Chondroitin Sulfate A", NIHON SHIKA HOZONGAKU ZASSHI, vol. 36, no. 3, 1993, pages 31 - 32, XP008179985
"Introduction to the Glycoscience Dai 5 Kai -Saibogai Matrix 2- Kenko na Karada o Sasaeru Urakata - Chondroitin Ryusan", 2007, XP055267080, Retrieved from the Internet
ZHANG JQ ET AL.: "Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes", J BIOL CHEM, vol. 275, no. 29, 2000, pages 22121 - 22126, XP002909451
ANDO Y ET AL.: "Stem cell -conditioned medium accelerates distraction osteogenesis through multiple regenerative mechanisms", BONE, vol. 61, 2014, pages 82 - 90, XP028667601
DAVID, S.; KRONER, A., NATURE REVIEWS NEUROSCIENCE, vol. 12, no. 7, pages 388 - 399
POPOVICH, P.G.; LONGBRAKE, E.E., NATURE REVIEWS NEUROSCIENCE, vol. 9, no. 6, pages 481 - 493
ALTSCHUL SF; GISH W; MILLER W; MYERS EW; LIPMAN DJ., J. MOL. BID., vol. 215, 1990, pages 403 - 410
ALTSCHUL SF; MADDEN TL; SCHAFFER AA; ZHANG J; MILLER W; LIPMAN DJ., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
See also references of EP 2937088A4
Attorney, Agent or Firm:
KAI-U PATENT LAW FIRM (JP)
Patent business corporation KAI-U Patent Law Firm (JP)
Patent business corporation KAI-U Patent Law Firm (JP)
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