Title:
COMPOSITION FOR MAINTENANCE AND/OR IMPROVEMENT OF MEMORY/LEARNING ABILITY, AND FOOD, MEDICINE AND FEED EACH CONTAINING SAID COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2021/015288
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a medicine, a food, a beverage and a feed which are effective for the prevention and/or improvement of the deterioration in a memory/learning ability which occurs in association with aging. Provided is a novel microorganism having an effect to prevent and/or improve the deterioration in a memory/learning ability which occurs in association with aging. More specifically, the microorganism is characterized by belonging to the genus Lactobacillus, Bifidobacterium, Streptococcus, Leuconostoc or Pediococcus. Still more specifically, the microorganism is characterized by belonging to any one of Lactobacillus acidophilus, Lactobacillus gasseri, Lactobacillus gallinarum, Lactobacillus johnsonii, Lactobacillus delbrueckii ssp. delbrueckii, Bifidobacterium catenulatum, Bifidobacterium pseudolongum, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum, Streptococcus thermophilus, Leuconostoc mesenteroides ssp. dextranicum, Leuconostoc lactis, Pediococcus acidilactici and Pediococcus pentosaceus.
Inventors:
HIGURASHI SATOSHI (JP)
NOMA KENTARO (JP)
MORI IKUE (JP)
NAKANO SHUNJI (JP)
TSUKADA YUKI (JP)
NOMA KENTARO (JP)
MORI IKUE (JP)
NAKANO SHUNJI (JP)
TSUKADA YUKI (JP)
Application Number:
PCT/JP2020/028686
Publication Date:
January 28, 2021
Filing Date:
July 27, 2020
Export Citation:
Assignee:
MEGMILK SNOW BRAND CO LTD (JP)
International Classes:
A23C9/12; A23K10/16; A23K10/18; A23L2/38; A23L2/52; A23L33/135; A61K35/744; A61K35/745; A61K35/747; A61P25/28
Domestic Patent References:
| WO2018143793A1 | 2018-08-09 |
Foreign References:
| JPH0923848A | 1997-01-28 | |||
| JP2018531595A | 2018-11-01 | |||
| JP2013005757A | 2013-01-10 | |||
| JP2013184956A | 2013-09-19 | |||
| JP2017197486A | 2017-11-02 | |||
| JP2015047121A | 2015-03-16 | |||
| KR20190000450A | 2019-01-03 | |||
| KR20110057550A | 2011-06-01 | |||
| CN107455698A | 2017-12-12 | |||
| CN108541951A | 2018-09-18 | |||
| JP2017222601A | 2017-12-21 | |||
| JP5155961B2 | 2013-03-06 | |||
| JP5155960B2 | 2013-03-06 | |||
| JP2015503913A | 2015-02-05 |
Other References:
ALLEN, A. P. ET AL.: "Bifidobacterium longum 1714 as a translational psychobiotic: modulation of stress, electrophysiology and neurocognition in healthy volunteers", TRANSL. PSYCHIATRY, vol. 6, no. e939, 2016, pages 1 - 7, XP055478533, DOI: 10.1038/tp. 2016.191
O'HAGAN, C. ET AL.: "Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats", NEUROBIOLOGY OF LEARNING AND MEMORY, vol. 144, 2017, pages 36 - 47, XP085185415, Retrieved from the Internet
PAROIS, S. ET AL.: "The influence of a probiotic supplementation on memory in quail suggests a role of gut microbiota on cognitive abilities in birds", BEHAVIOURAL BRAIN RESEARCH, vol. 331, 2017, pages 47 - 53, XP085063858, Retrieved from the Internet DOI: 10.1016/j.bbr.2017.05.022
NI, Y. ET AL.: "Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota", MOL. NUTR. FOOD RES., vol. 63, no. 22, 25 September 2019 (2019-09-25), pages 1900603, XP055787711, DOI: 10.1002/mnfr.201900603
NAGASAKI, Y. ET AL.: "Effect of a Dietary Supplement Containing Heat-killed Bifidobacterium longum N61 on Neurocognitive Functions in Healthy Old Adults with Perceived Memory Impairment, A Randomized Double-blind, Placebo- controlled Trial", JAPANESE PHARMACOLOGY & THERAPEUTICS, vol. 47, no. 10, 20 October 2019 (2019-10-20), pages 1677 - 1688, XP009533164, ISSN: 0386-3603
LEE, HAE-JI ET AL.: "Lactobacillus johnsonii CJLJ103 Attenuates Scopolamine- Induced Memory Impairment in Mice by Increasing BDNF Expression and Inhibiting NF-kappaB Activation", J. MICROBIOL. BIOTECHNOL., vol. 28, no. 9, 2018, pages 1443 - 1446, XP055571696, DOI: https://doi.org/10.4014/jmb.1805.05025
KATSUYOSHI MIZUKAMI, PSYCHIATRIA ET NEUROLOGIA JAPONICA, vol. 111, 2009, pages 26 - 30
HEDGECOCK, E. M.RUSSELL, R. L.: "Normal and mutant thermotaxis in the nematode Caenorhabditis elegans", PROC. NATL. ACAD. SCI. USA, vol. 72, 1975, pages 4061 - 4065
MOHRI, A.KODAMA, E.KIMURA, K. D. ET AL.: "Genetic control of temperature preference in the nematode Caenorhabditis elegans", GENETICS, vol. 169, 2005, pages 1437 - 1450
ITO, H.INADA, H.MORI, I.: "Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans", J. NEUROSCI. METHODS, vol. 154, 2006, pages 45 - 52, XP024996995, DOI: 10.1016/j.jneumeth.2005.11.011
MORI, I.SASAKURA, H.KUHARA, A.: "Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity", CURR. OPIN. NEUROBIOL., vol. 17, 2007, pages 712 - 719, XP022542051, DOI: 10.1016/j.conb.2007.11.010
MORI, I.OHSHIMA, Y: "Neural regulation of thermotaxis in Caenorhabditis elegans", NATURE, vol. 376, 1995, pages 344 - 348
SUGI, T.NISHIDA, YMORI, I.: "Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans", NAT. NEUROSCI., vol. 14, 2011, pages 984 - 92
NISHIDA, Y.SUGI, T.NONOMURA, M. ET AL.: "Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis", EMBO REP., vol. 12, 2011, pages 855 - 862
LI, Y.ZHAO, YHUANG, X ET AL.: "Serotonin control of thermotaxis memory behavior in nematode Caenorhabditis elegans", PLOS ONE., vol. 8, 2013, pages 1 - 10
LI, W.BELL, H. W.AHNN, J.LEE, S. K.: "Regulator of Calcineurin (RCAN-1) Regulates Thermotaxis Behavior in Caenorhabditis elegans", J. MOL. BIOL., vol. 427, 2015, pages 3457 - 3468
MURAKAMI, S.MURAKAMI, H.: "The effects of aging and oxidative stress on learning behavior in C. elegans", NEUROBIOL. AGING., vol. 26, 2005, pages 899 - 905, XP004755468, DOI: 10.1016/j.neurobiolaging.2004.08.007
CUI, Y.SHU, Y.ZHU, Y.SHI, Y.LE, G.: "High-fat diets impair spatial learning of mice in the Y-maze paradigm: ameliorative potential of a-lipoic acid", J. MED. FOOD., vol. 15, 2012, pages 713 - 7
NEUROBIOL AGING., vol. 39, 2016, pages 69 - 81
SARKER, M. R.FRANKS, S. F..: "Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies", GEROSCIENCE., vol. 40, 2018, pages 73 - 95, XP036510761, DOI: 10.1007/s11357-018-0017-z
MIYASAKA, TXIE, C.YOSHIMURA, S. ET AL.: "Curcumin improves tau-induced neuronal dysfunction of nematodes", NEUROBIOL. AGING., vol. 39, 2016, pages 69 - 81, XP029434620, DOI: 10.1016/j.neurobiolaging.2015.11.004
ITO H. ET AL., J. NEUROSCI. METHODS, vol. 154, 2006, pages 45 - 52
O'HAGAN, C. ET AL.: "Long-term multi-species Lactobacillus and Bifidobacterium dietary supplement enhances memory and changes regional brain metabolites in middle-aged rats", NEUROBIOLOGY OF LEARNING AND MEMORY, vol. 144, 2017, pages 36 - 47, XP085185415, Retrieved from the Internet
PAROIS, S. ET AL.: "The influence of a probiotic supplementation on memory in quail suggests a role of gut microbiota on cognitive abilities in birds", BEHAVIOURAL BRAIN RESEARCH, vol. 331, 2017, pages 47 - 53, XP085063858, Retrieved from the Internet
NI, Y. ET AL.: "Lactobacillus and Bifidobacterium Improves Physiological Function and Cognitive Ability in Aged Mice by the Regulation of Gut Microbiota", MOL. NUTR. FOOD RES., vol. 63, no. 22, 25 September 2019 (2019-09-25), pages 1900603, XP055787711, DOI: 10.1002/mnfr.201900603
NAGASAKI, Y. ET AL.: "Effect of a Dietary Supplement Containing Heat-killed Bifidobacterium longum N61 on Neurocognitive Functions in Healthy Old Adults with Perceived Memory Impairment, A Randomized Double-blind, Placebo- controlled Trial", JAPANESE PHARMACOLOGY & THERAPEUTICS, vol. 47, no. 10, 20 October 2019 (2019-10-20), pages 1677 - 1688, XP009533164, ISSN: 0386-3603
LEE, HAE-JI ET AL.: "Lactobacillus johnsonii CJLJ103 Attenuates Scopolamine- Induced Memory Impairment in Mice by Increasing BDNF Expression and Inhibiting NF-kappaB Activation", J. MICROBIOL. BIOTECHNOL., vol. 28, no. 9, 2018, pages 1443 - 1446, XP055571696, DOI: https://doi.org/10.4014/jmb.1805.05025
KATSUYOSHI MIZUKAMI, PSYCHIATRIA ET NEUROLOGIA JAPONICA, vol. 111, 2009, pages 26 - 30
HEDGECOCK, E. M.RUSSELL, R. L.: "Normal and mutant thermotaxis in the nematode Caenorhabditis elegans", PROC. NATL. ACAD. SCI. USA, vol. 72, 1975, pages 4061 - 4065
MOHRI, A.KODAMA, E.KIMURA, K. D. ET AL.: "Genetic control of temperature preference in the nematode Caenorhabditis elegans", GENETICS, vol. 169, 2005, pages 1437 - 1450
ITO, H.INADA, H.MORI, I.: "Quantitative analysis of thermotaxis in the nematode Caenorhabditis elegans", J. NEUROSCI. METHODS, vol. 154, 2006, pages 45 - 52, XP024996995, DOI: 10.1016/j.jneumeth.2005.11.011
MORI, I.SASAKURA, H.KUHARA, A.: "Worm thermotaxis: a model system for analyzing thermosensation and neural plasticity", CURR. OPIN. NEUROBIOL., vol. 17, 2007, pages 712 - 719, XP022542051, DOI: 10.1016/j.conb.2007.11.010
MORI, I.OHSHIMA, Y: "Neural regulation of thermotaxis in Caenorhabditis elegans", NATURE, vol. 376, 1995, pages 344 - 348
SUGI, T.NISHIDA, YMORI, I.: "Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans", NAT. NEUROSCI., vol. 14, 2011, pages 984 - 92
NISHIDA, Y.SUGI, T.NONOMURA, M. ET AL.: "Identification of the AFD neuron as the site of action of the CREB protein in Caenorhabditis elegans thermotaxis", EMBO REP., vol. 12, 2011, pages 855 - 862
LI, Y.ZHAO, YHUANG, X ET AL.: "Serotonin control of thermotaxis memory behavior in nematode Caenorhabditis elegans", PLOS ONE., vol. 8, 2013, pages 1 - 10
LI, W.BELL, H. W.AHNN, J.LEE, S. K.: "Regulator of Calcineurin (RCAN-1) Regulates Thermotaxis Behavior in Caenorhabditis elegans", J. MOL. BIOL., vol. 427, 2015, pages 3457 - 3468
MURAKAMI, S.MURAKAMI, H.: "The effects of aging and oxidative stress on learning behavior in C. elegans", NEUROBIOL. AGING., vol. 26, 2005, pages 899 - 905, XP004755468, DOI: 10.1016/j.neurobiolaging.2004.08.007
CUI, Y.SHU, Y.ZHU, Y.SHI, Y.LE, G.: "High-fat diets impair spatial learning of mice in the Y-maze paradigm: ameliorative potential of a-lipoic acid", J. MED. FOOD., vol. 15, 2012, pages 713 - 7
NEUROBIOL AGING., vol. 39, 2016, pages 69 - 81
SARKER, M. R.FRANKS, S. F..: "Efficacy of curcumin for age-associated cognitive decline: a narrative review of preclinical and clinical studies", GEROSCIENCE., vol. 40, 2018, pages 73 - 95, XP036510761, DOI: 10.1007/s11357-018-0017-z
MIYASAKA, TXIE, C.YOSHIMURA, S. ET AL.: "Curcumin improves tau-induced neuronal dysfunction of nematodes", NEUROBIOL. AGING., vol. 39, 2016, pages 69 - 81, XP029434620, DOI: 10.1016/j.neurobiolaging.2015.11.004
ITO H. ET AL., J. NEUROSCI. METHODS, vol. 154, 2006, pages 45 - 52
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MOEGI PATENT OFFICE (JP)
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