Title:
COMPOSITION AND METHOD FOR TREATING CANDIDA AURIS INFECTION
Document Type and Number:
WIPO Patent Application WO/2021/090739
Kind Code:
A1
Abstract:
Candida auris infection in a subject is treated with 4-{3-[4-(3-{4-[amino(imino)methyl]phenoxy}propyl)-1-piperidinyl]propoxy}benzamidine (T-2307) or a pharmaceutically acceptable salt thereof.
More Like This:
Inventors:
PATTERSON THOMAS F (US)
WIEDERHOLD NATHAN P (US)
NAJVAR LAURA K (US)
WIEDERHOLD NATHAN P (US)
NAJVAR LAURA K (US)
Application Number:
PCT/JP2020/040374
Publication Date:
May 14, 2021
Filing Date:
October 28, 2020
Export Citation:
Assignee:
FUJIFILM TOYAMA CHEMICAL CO LTD (JP)
International Classes:
A61K31/445; A61P31/10
Other References:
KAMEI, KATSUHIKO : "Increasing opportunistic fungal infections. Trends and measures", MEBIO, vol. 33, no. 12, 1 January 2016 (2016-01-01), pages 39 - 46, XP009528077, ISSN: 0910-0474
MITSUYAMA JUNICHI, ET AL: "In vitro and in vivo antifungal activities of T-2307, a novel arylamidine.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 52, no. 4, 1 April 2008 (2008-04-01), US, pages 1318 - 1324, XP002557123, ISSN: 0066-4804, DOI: 10.1128/AAC.01159-07
HAMAMOTO, HIROSHI: "Current reality and issues for development of novel antifungal agents", ANTIBIOTICS & CHEMOTHERAPY, vol. 34, no. S1, 1 January 2018 (2018-01-01), pages 53 - 61, XP009528078, ISSN: 0913-2384
WIEDERHOLD NATHAN P., NAJVAR LAURA K., SHAW KAREN J., JARAMILLO ROSIE, PATTERSON HOJA, OLIVO MARCOS, CATANO GABRIEL, PATTERSON THO: "Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis, Antimicrobial Agents and Chemotherapy", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 63, no. 11, 1 November 2019 (2019-11-01), US, XP055812644, ISSN: 0066-4804, DOI: 10.1128/AAC.01120-19
MITSUYAMA JUNICHI, ET AL: "In vitro and in vivo antifungal activities of T-2307, a novel arylamidine.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 52, no. 4, 1 April 2008 (2008-04-01), US, pages 1318 - 1324, XP002557123, ISSN: 0066-4804, DOI: 10.1128/AAC.01159-07
HAMAMOTO, HIROSHI: "Current reality and issues for development of novel antifungal agents", ANTIBIOTICS & CHEMOTHERAPY, vol. 34, no. S1, 1 January 2018 (2018-01-01), pages 53 - 61, XP009528078, ISSN: 0913-2384
WIEDERHOLD NATHAN P., NAJVAR LAURA K., SHAW KAREN J., JARAMILLO ROSIE, PATTERSON HOJA, OLIVO MARCOS, CATANO GABRIEL, PATTERSON THO: "Efficacy of Delayed Therapy with Fosmanogepix (APX001) in a Murine Model of Candida auris Invasive Candidiasis, Antimicrobial Agents and Chemotherapy", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 63, no. 11, 1 November 2019 (2019-11-01), US, XP055812644, ISSN: 0066-4804, DOI: 10.1128/AAC.01120-19
Attorney, Agent or Firm:
ASAMURA PATENT OFFICE, P.C. (JP)
Download PDF: