Title:
COMPOSITION FOR PREVENTING OR ALLEVIATING LIFESTYLE DISEASES
Document Type and Number:
WIPO Patent Application WO/2021/029322
Kind Code:
A1
Abstract:
[Problem] The present invention addresses the problem of providing a composition for preventing or alleviating lifestyle diseases by way of a safe substance. [Solution] The inventors discovered a function that promotes intestinal microbial fermentation in curdlan of 30 μm or smaller in mean particle diameter and arrived at the present invention. The present invention can cause the level of short-chain fatty acids, which are metabolites derived from gut microbiota, to rise significantly and regulate the intestinal environment. In addition, since an improvement of the intestinal environment improves systemic metabolism or immune functions, the present invention also has the effect of preventing lifestyle diseases.
Inventors:
KITANO RYUJI (JP)
KIMURA IKUO (JP)
OGASAWARA MASASHI (JP)
ETO SHINICHI (JP)
OKABE YUI (JP)
KIMURA IKUO (JP)
OGASAWARA MASASHI (JP)
ETO SHINICHI (JP)
OKABE YUI (JP)
Application Number:
PCT/JP2020/030195
Publication Date:
February 18, 2021
Filing Date:
August 06, 2020
Export Citation:
Assignee:
MITSUBISHI CORPORATION LIFE SCIENCES LTD (JP)
NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP)
NATIONAL UNIV CORPORATION TOKYO UNIV OF AGRICULTURE AND TECHNOLOGY (JP)
International Classes:
A61P1/04; A23L29/269; A23L33/21; A61K31/716; A61P3/02; A61P3/04; A61P3/06; A61P37/02
Other References:
SHIMIZU, J. ET AL.: "Dietary Curdlan Increases Proliferation of Bifidobacteria in The Cecum of Rats", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, vol. 65, no. 2, January 2001 (2001-01-01), pages 466 - 469, XP055793300, ISSN: 1347-6947
TUNCIL, Y. E. ET AL.: "Divergent short-chain fatty acid production and succession of colonic microbiota arise in fermentation of variously-sized wheat bran fractions", SCIENTIFIC REPORTS, vol. 8, no. 1, 9 November 2018 (2018-11-09), pages 16655, XP055793303, ISSN: 2045-2322
IWAI, K. ET AL.: "Effects of Short-Term Intake of Wheat Bran with Different Particle Sizes on the Murine Intestinal Environment", FOOD SCIENCE AND TECHNOLOGY RESEARCH, vol. 23, no. 5, 2017, pages 733 - 742, XP055793306, ISSN: 1344-6606
VERMEULEN, K. ET AL.: "Reduced particle size wheat bran is butyrogenic and lowers Salmonella colonization, when added to poultry feed", VETERINARY MICROBIOLOGY, vol. 198, 2017, pages 64 - 71, XP029874447, ISSN: 0378-1135, DOI: 10.1016/j.vetmic.2016.12.009
HIROTA MASATO ET AL: "Regulation of the Autoimmune and Allergic Responses by Short-chain Fatty Acids", LUMINACOIDS RESEARCH, vol. 23, no. 1, 30 June 2019 (2019-06-30), pages 11 - 20
TUNCIL, Y. E. ET AL.: "Divergent short-chain fatty acid production and succession of colonic microbiota arise in fermentation of variously-sized wheat bran fractions", SCIENTIFIC REPORTS, vol. 8, no. 1, 9 November 2018 (2018-11-09), pages 16655, XP055793303, ISSN: 2045-2322
IWAI, K. ET AL.: "Effects of Short-Term Intake of Wheat Bran with Different Particle Sizes on the Murine Intestinal Environment", FOOD SCIENCE AND TECHNOLOGY RESEARCH, vol. 23, no. 5, 2017, pages 733 - 742, XP055793306, ISSN: 1344-6606
VERMEULEN, K. ET AL.: "Reduced particle size wheat bran is butyrogenic and lowers Salmonella colonization, when added to poultry feed", VETERINARY MICROBIOLOGY, vol. 198, 2017, pages 64 - 71, XP029874447, ISSN: 0378-1135, DOI: 10.1016/j.vetmic.2016.12.009
HIROTA MASATO ET AL: "Regulation of the Autoimmune and Allergic Responses by Short-chain Fatty Acids", LUMINACOIDS RESEARCH, vol. 23, no. 1, 30 June 2019 (2019-06-30), pages 11 - 20
Attorney, Agent or Firm:
ENOMOTO, Masahiko (JP)
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