Title:
COMPOSITION FOR PREVENTING, ALLEVIATING OR TREATING ALOPECIA OR POLIOSIS THROUGH ALDEHYDE DEHYDROGENASE 2 REGULATION
Document Type and Number:
WIPO Patent Application WO/2023/146274
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, alleviating and/or treating alopecia or poliosis (or poliosis circumscripta), and the like, and was accomplished by identifying that an aldehyde dehydrogenase 2 (ALDH2) activator promotes hair follicle formation and hair growth and has an excellent effect on inhibiting the oxidative stress of hair follicles. Therefore, the ALDH2 activator according to the present invention can be used as a preparation for preventing, alleviating and/or treating alopecia and poliosis. Furthermore, combination treatment of the ALDH2 activator and minoxidil exhibited better alopecia prevention and treatment effects. Therefore, ALDH2, itself, according to the present invention, effectively promotes hair growth, and is expected to be effectively used, in combination with minoxidil, in medical, beauty and food item fields in order to prevent, alleviate and treat alopecia.
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Inventors:
KWON OHSANG (KR)
LEE SEUNGHEE (KR)
OHN JUNGYOON (KR)
LEE SEUNGHEE (KR)
OHN JUNGYOON (KR)
Application Number:
PCT/KR2023/001139
Publication Date:
August 03, 2023
Filing Date:
January 25, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV HOSPITAL (KR)
International Classes:
A61K31/36; A23L33/10; A61K8/49; A61K31/506; A61K45/06; A61P17/00; A61P17/14; A61Q5/00; A61Q7/00
Foreign References:
| KR20190016283A | 2019-02-18 | |||
| KR20190053408A | 2019-05-20 |
Other References:
BRUNSDON HANNAH, BROMBIN ALESSANDRO, PETERSON SAMUEL, POSTLETHWAIT JOHN H., PATTON E. ELIZABETH: "Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells", DEVELOPMENT, THE COMPANY OF BIOLOGISTS LTD., GB, vol. 149, no. 10, 15 May 2022 (2022-05-15), GB , pages dev200277, XP093080182, ISSN: 0950-1991, DOI: 10.1242/dev.200277
DONG XINHANG; ZHANG MINGZI; JIN XIAOLEI: "Alda-1, an Aldehyde Dehydrogenase 2 Agonist, Improves Cutaneous Wound Healing by Activating Epidermal Keratinocytes Via Akt/GSK-3β/β-Catenin Pathway", AESTHETIC PLASTIC SURGERY, SPRINGER VERLAG, NEW YORK, NY, US, vol. 46, no. Suppl 1, 25 August 2021 (2021-08-25), US , pages 125 - 125, XP037930620, ISSN: 0364-216X, DOI: 10.1007/s00266-021-02536-5
HUA YUE, CHEN HONGMEI, ZHAO XINYUN, LIU MIN, JIN WEN, YAN WEN, WU YIFEN, TAN ZHANGBIN, FAN HUIJIE, WU YUTING, XIE LINGPENG, ZHANG : "Alda‑1, an aldehyde dehydrogenase‑2 agonist, improves long‑term survival in rats with chronic heart failure following myocardial infarction", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 18, 24 July 2018 (2018-07-24), GR , pages 3159 - 3166, XP093080185, ISSN: 1791-2997, DOI: 10.3892/mmr.2018.9309
DONG XINHANG; ZHANG MINGZI; JIN XIAOLEI: "Alda-1, an Aldehyde Dehydrogenase 2 Agonist, Improves Cutaneous Wound Healing by Activating Epidermal Keratinocytes Via Akt/GSK-3β/β-Catenin Pathway", AESTHETIC PLASTIC SURGERY, SPRINGER VERLAG, NEW YORK, NY, US, vol. 46, no. Suppl 1, 25 August 2021 (2021-08-25), US , pages 125 - 125, XP037930620, ISSN: 0364-216X, DOI: 10.1007/s00266-021-02536-5
HUA YUE, CHEN HONGMEI, ZHAO XINYUN, LIU MIN, JIN WEN, YAN WEN, WU YIFEN, TAN ZHANGBIN, FAN HUIJIE, WU YUTING, XIE LINGPENG, ZHANG : "Alda‑1, an aldehyde dehydrogenase‑2 agonist, improves long‑term survival in rats with chronic heart failure following myocardial infarction", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, vol. 18, 24 July 2018 (2018-07-24), GR , pages 3159 - 3166, XP093080185, ISSN: 1791-2997, DOI: 10.3892/mmr.2018.9309
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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