Title:
COMPOSITION FOR PREVENTING OR IMPROVING NOCICEPTIVE PAIN
Document Type and Number:
WIPO Patent Application WO/2019/146735
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition having a preventative or ameliorative effect on nociceptive pain. The present invention relates to a composition for preventing or improving nociceptive pain that contains amino acids including serine and lipids including n-3 fatty acids.
Inventors:
SUGA YASUYO (JP)
SASAHARA IKUKO (JP)
HASHIMOTO MASAKI (JP)
MINE TOMOYUKI (JP)
TAKADA MICHIHIRO (JP)
ISHII MAKOTO (JP)
KANZAKI MICHIYA (JP)
SASAHARA IKUKO (JP)
HASHIMOTO MASAKI (JP)
MINE TOMOYUKI (JP)
TAKADA MICHIHIRO (JP)
ISHII MAKOTO (JP)
KANZAKI MICHIYA (JP)
Application Number:
PCT/JP2019/002387
Publication Date:
August 01, 2019
Filing Date:
January 25, 2019
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
A61K31/202; A23L33/115; A23L33/175; A61K31/198; A61P25/04; A61P43/00
Domestic Patent References:
| WO2015163316A1 | 2015-10-29 | |||
| WO2015163316A1 | 2015-10-29 |
Foreign References:
| JP2005529980A | 2005-10-06 | |||
| JP2015091817A | 2015-05-14 | |||
| US20170035721A1 | 2017-02-09 | |||
| JP2018011964A | 2018-01-25 |
Other References:
JEONG, Y. C. ET AL.: "Inhibition of mitogen- activated protein kinases phosphorylation plays an important role in the anti-nociceptive effect of pregabalin in zymosan-induced inflammatory pain model", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 37, no. 10, 2014, pages 1694 - 1698, XP055628820, ISSN: 0918-6158
GUERRERO, A. T. G. ET AL.: "Toll-like receptor 2/MyD88 signaling mediates zymosan-induced joint hypernociception in mice: Participation of TNF-a, IL -Ibeta and CXCL/KC", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 674, no. 1, 2011, pages 51 - 57, XP028126047, ISSN: 0014-2999
ALVES, S. M. ET AL.: "Anti-inflammatory and anti- nociceptive effects of strontium ranelate on the zymosan-induced temporomandibular joint inflammatory hypernociception in rats depend on TNF-oi inhibition", PHARMACOLOGICAL REPORTS, vol. 69, no. 4, 2017, pages 764 - 772, XP055628823, ISSN: 1734-1140
ITO, MIHO ET AL.: "Antinociceptive effect of intracerebroventricular administration or D-serine on formalin-induced pain", JOURNAL OF ANESTHESIA, vol. 28, no. 2, 2014, pages 228 - 234, XP055628824, ISSN: 0913-8668
ITO, KENJI ET AL.: "Midazolam attenuated the antinociceptive effect of D-serine and morphine at supraspinal level", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 103, 2007, pages 236P, XP022671772, ISSN: 1347-8613
NAKAMOTO, KAZUO ET AL.: "Antinociceptive effects of docosahexaenoic acid against various pain stimuli in mice", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 33, no. 6, 2010, pages 1070 - 1072, XP008136227, ISSN: 0918-6158
NOBRE, M. E. P. ET AL.: "Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammtory and antinociceptive effects in rodents at low doses", NUTRITION RESEARCH, vol. 33, no. 5, 2013, pages 422 - 433, XP028563943, ISSN: 0271-5317
NEUROLOGICAL THERAPEUTICS, vol. 27, no. 4, 2010, pages 591 - 622
CLINICAL ORTHOPAEDIC SURGERY, vol. 47, no. 2, 2012, pages 127 - 134
JOURNAL OF ALLIED HEALTH SCIENCES, vol. 8, no. 1, 2017, pages 50 - 63
FREYNHAGEN ET AL., CURR MED RES OPIN, vol. 22, no. 10, 2006, pages 1911 - 20
GUERRERO, A. T. G. ET AL.: "Toll-like receptor 2/MyD88 signaling mediates zymosan-induced joint hypernociception in mice: Participation of TNF-a, IL -Ibeta and CXCL/KC", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 674, no. 1, 2011, pages 51 - 57, XP028126047, ISSN: 0014-2999
ALVES, S. M. ET AL.: "Anti-inflammatory and anti- nociceptive effects of strontium ranelate on the zymosan-induced temporomandibular joint inflammatory hypernociception in rats depend on TNF-oi inhibition", PHARMACOLOGICAL REPORTS, vol. 69, no. 4, 2017, pages 764 - 772, XP055628823, ISSN: 1734-1140
ITO, MIHO ET AL.: "Antinociceptive effect of intracerebroventricular administration or D-serine on formalin-induced pain", JOURNAL OF ANESTHESIA, vol. 28, no. 2, 2014, pages 228 - 234, XP055628824, ISSN: 0913-8668
ITO, KENJI ET AL.: "Midazolam attenuated the antinociceptive effect of D-serine and morphine at supraspinal level", JOURNAL OF PHARMACOLOGICAL SCIENCES, vol. 103, 2007, pages 236P, XP022671772, ISSN: 1347-8613
NAKAMOTO, KAZUO ET AL.: "Antinociceptive effects of docosahexaenoic acid against various pain stimuli in mice", BIOLOGICAL AND PHARMACEUTICAL BULLETIN, vol. 33, no. 6, 2010, pages 1070 - 1072, XP008136227, ISSN: 0918-6158
NOBRE, M. E. P. ET AL.: "Eicosapentaenoic acid and docosahexaenoic acid exert anti-inflammtory and antinociceptive effects in rodents at low doses", NUTRITION RESEARCH, vol. 33, no. 5, 2013, pages 422 - 433, XP028563943, ISSN: 0271-5317
NEUROLOGICAL THERAPEUTICS, vol. 27, no. 4, 2010, pages 591 - 622
CLINICAL ORTHOPAEDIC SURGERY, vol. 47, no. 2, 2012, pages 127 - 134
JOURNAL OF ALLIED HEALTH SCIENCES, vol. 8, no. 1, 2017, pages 50 - 63
FREYNHAGEN ET AL., CURR MED RES OPIN, vol. 22, no. 10, 2006, pages 1911 - 20
Attorney, Agent or Firm:
TAKASHIMA, Hajime (JP)
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