Title:
COMPOSITION, FOR PREVENTING, REMEDYING OR TREATING FEMALE CLIMACTERIC SYNDROME, CONTAINING LOGANIN OR DERIVATIVE OF SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/123030
Kind Code:
A1
Abstract:
The present invention relates to a composition, for preventing, remedying or treating female climacteric syndrome, containing loganin, a derivative of same or pharmaceutically acceptable salts of same as an active ingredient. Loganin, according to the present invention, enables an increase in the estradiol (17β-estradiol, E2) concentration in the blood of a menopausal mouse model and has shown effects such as: an increase in the estrogen receptor alpha expression in the uterus; remedying of uterine contraction and degeneration; a decrease in the size and accumulation of adipocytes in the abdominal adipose tissues and the liver; and weight loss. Therefore, loganin enables remedying of symptoms in menopausal women such as loss of estrogen, weight gain, and size increase in adipocytes and fat accumulation in the abdominal adipose tissues and the liver. Therefore, loganin and a composition comprising same as an active ingredient, according to the present invention, are expected to be utilized as a pharmaceutical preparation for preventing and remedying climacteric symptoms.
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Inventors:
JEONG SEON-YONG (KR)
PARK EUN KUK (KR)
KIM MUN-CHANG (KR)
KIM JEONG HYUN (KR)
PARK EUN KUK (KR)
KIM MUN-CHANG (KR)
KIM JEONG HYUN (KR)
Application Number:
PCT/KR2017/000438
Publication Date:
July 20, 2017
Filing Date:
January 13, 2017
Export Citation:
Assignee:
AJOU UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)
NINE B CO LTD (KR)
NINE B CO LTD (KR)
International Classes:
A61K31/7048; A23L33/10
Foreign References:
| CN104887693A | 2015-09-09 | |||
| KR101225566B1 | 2013-01-23 | |||
| KR20150037208A | 2015-04-08 |
Other References:
LI, M. ET AL.: "The Pharmacological Effects of Morroniside and Loganin Isolated from Liuweidihuang Wan, onMC3T3-El Cells", MOLECULES, vol. 15, 2010, pages 7403 - 7414, XP055400553
PARK JIN-HYEOK: "Development of Functional Foods Having an Effect on Prevention and Improvement of Osteoporosis via Regulating the Key Gene Expression Associated with Bone Metabolism", DONGWOODANG PHARMACY CO., LTD., 2015, pages 1 - 115, XP009513503
See also references of EP 3403656A4
PARK JIN-HYEOK: "Development of Functional Foods Having an Effect on Prevention and Improvement of Osteoporosis via Regulating the Key Gene Expression Associated with Bone Metabolism", DONGWOODANG PHARMACY CO., LTD., 2015, pages 1 - 115, XP009513503
See also references of EP 3403656A4
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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