Title:
COMPOSITION, FOR PREVENTING, REMEDYING OR TREATING FEMALE POSTMENOPAUSAL OSTEOPOROSIS, CONTAINING LOGANIN OR DERIVATIVE OF SAME AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2017/123031
Kind Code:
A1
Abstract:
The present invention relates to a composition, for preventing, remedying or treating female postmenopausal osteoporosis, containing loganin, a derivative of same or pharmaceutically acceptable salts of same as an active ingredient. Loganin, according to the present invention, is effective in inhibiting osteoclast differentiation as well as inhibiting postmenopausal bone density loss, bone microarchitecture degradation, a bone resorption marker increase in the blood and a decrease in bone formation markers. Therefore, loganin and a composition comprising same as an active ingredient, according to the present invention, are expected to be utilized as a pharmaceutical preparation for preventing, remedying and treating female postmenopausal osteoporosis.
Inventors:
JEONG SEON-YONG (KR)
PARK EUN KUK (KR)
KIM MUN-CHANG (KR)
KIM JEONG HYUN (KR)
PARK EUN KUK (KR)
KIM MUN-CHANG (KR)
KIM JEONG HYUN (KR)
Application Number:
PCT/KR2017/000439
Publication Date:
July 20, 2017
Filing Date:
January 13, 2017
Export Citation:
Assignee:
AJOU UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)
NINE B CO LTD (KR)
NINE B CO LTD (KR)
International Classes:
A61K31/7048; A23L33/10
Foreign References:
| CN104887693A | 2015-09-09 | |||
| KR101225566B1 | 2013-01-23 | |||
| KR20150037208A | 2015-04-08 |
Other References:
LI, M.: "The pharmacological effects of morroniside and loganin isolated from Liuweidihuang Wan , on MC 3T3-E1 cells", MOLECULES, vol. 15, 2010, pages 7403 - 7414, XP055400553, DOI: doi:10.3390/molecules15107403
DONGWOODANG PHARMACY CO. LTD: "Development of Functional Foods Having an Effect on Prevention and Improvement of Osteoporosis via Regulating the key gene Expression Associated with Bone Metabolism", 2015, pages 63 - 64
DONGWOODANG PHARMACY CO. LTD: "Development of Functional Foods Having an Effect on Prevention and Improvement of Osteoporosis via Regulating the key gene Expression Associated with Bone Metabolism", 2015, pages 63 - 64
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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