Title:
COMPOSITION FOR PREVENTING, TREATING, OR ALLEVIATING ARTHRITIS, COMPRISING ELAEOCARPUS SYLVESTRIS EXTRACT OR MIXTURE OF ELAEOCARPUS SYLVESTRIS EXTRACT AND SULFASALAZINE AS AN ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/017958
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing, treating, or alleviating arthritis, comprising an Elaeocarpus sylvestris extract or a mixture of an Elaeocarpus sylvestris extract and sulfasalazine as an active ingredient, and the Elaeocarpus sylvestris extract according to the present invention suppresses the production of nitric oxide, suppresses inflammatory cytokines, suppresses the production of iNOS or COX-2, suppresses the activity of NF-κB or IκBα, suppresses aggrecan expression, reduces an arthritis index, or exhibits foot edema inhibitory activity, and in particular, it was confirmed that a mixture of an Elaeocarpus sylvestris extract and sulfasalazine had excellent effects of suppressing the production of nitric oxide, suppressing inflammatory cytokines, suppressing the production of iNOS or COX-2, suppressing the activity of NF-κB or IκBα, reducing an arthritis index, or suppressing foot edema compared to the case of treatment with sulfasalazine alone. Thus, the Elaeocarpus sylvestris extract or a mixture of the Elaeocarpus sylvestris extract and sulfasalazine is expected to be usefully used for the development of a safe and effective medical product, health functional food, or the like for treating arthritis with few side effects.
Inventors:
KANG SE CHAN (KR)
JEONG YONG JOON (KR)
PARK JAE HYUN (KR)
KIM TAE WOO (KR)
HER YANG MI (KR)
PARK DAE WON (KR)
LEE YEONG-GEUN (KR)
KWON JEONG EUN (KR)
JEONG YONG JOON (KR)
PARK JAE HYUN (KR)
KIM TAE WOO (KR)
HER YANG MI (KR)
PARK DAE WON (KR)
LEE YEONG-GEUN (KR)
KWON JEONG EUN (KR)
Application Number:
PCT/KR2022/005931
Publication Date:
February 16, 2023
Filing Date:
April 26, 2022
Export Citation:
Assignee:
GENENCELL CO LTD (KR)
International Classes:
A61K36/185; A23L33/105; A61K31/4402; A61P19/02; A61P29/00
Foreign References:
| KR20190123384A | 2019-11-01 | |||
| EP3488868A1 | 2019-05-29 | |||
| KR20190036298A | 2019-04-04 | |||
| KR101834872B1 | 2018-04-13 |
Other References:
R. L. LAKEY, CAWSTON T. E.: "Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases", RHEUMATOLOGY, OXFORD UNIVERSITY PRESS, LONDON, GB, vol. 48, no. 10, 1 January 2009 (2009-01-01), GB , pages 1208 - 1212, XP055495727, ISSN: 1462-0324, DOI: 10.1093/rheumatology/kep236
ANONYMOUS: "Therapeutic agent for degenerative arthritis", MEDI:GATE NEWS, 28 April 2021 (2021-04-28), XP093034669, Retrieved from the Internet [retrieved on 20230324]
NEGI MANORMA, BAEK HYUN-JIN, PARK DAE WON, SO RINA, KWON JEONG EUN, JEON HYELIN, JEONG YONG JOON, PARK JAE-HYUN, KIM INHYE, KIM TA: "Elaeocarpus sylvestris extract (ESE) inhibits inflammatory mediators and increases the efficacy of sulfasalazine in rheumatoid arthritis", PHYTOMEDICINE PLUS, vol. 2, no. 1, 1 February 2022 (2022-02-01), pages 100207, XP093034670, ISSN: 2667-0313, DOI: 10.1016/j.phyplu.2021.100207
ANONYMOUS: "Therapeutic agent for degenerative arthritis", MEDI:GATE NEWS, 28 April 2021 (2021-04-28), XP093034669, Retrieved from the Internet
NEGI MANORMA, BAEK HYUN-JIN, PARK DAE WON, SO RINA, KWON JEONG EUN, JEON HYELIN, JEONG YONG JOON, PARK JAE-HYUN, KIM INHYE, KIM TA: "Elaeocarpus sylvestris extract (ESE) inhibits inflammatory mediators and increases the efficacy of sulfasalazine in rheumatoid arthritis", PHYTOMEDICINE PLUS, vol. 2, no. 1, 1 February 2022 (2022-02-01), pages 100207, XP093034670, ISSN: 2667-0313, DOI: 10.1016/j.phyplu.2021.100207
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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