Title:
COMPOSITION FOR PREVENTING OR TREATING AMYOTROPHIC LATERAL SCLEROSIS USING TWO OR MORE ISOFORMS OF HEPATOCYTE GROWTH FACTOR
Document Type and Number:
WIPO Patent Application WO/2015/060650
Kind Code:
A3
Abstract:
The present invention relates to a composition for preventing or treating amyotrophic lateral sclerosis, the composition containing, as an active ingredient, two or more isoforms of a hepatocyte growth factor (HGF) or a polynucleotide encoding the isoforms. The composition of the present invention is used to effectively prevent or treat amyotrophic lateral sclerosis.
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Inventors:
JEONG JAE-GYUN (KR)
Application Number:
PCT/KR2014/009971
Publication Date:
June 11, 2015
Filing Date:
October 22, 2014
Export Citation:
Assignee:
VIROMED CO LTD (KR)
International Classes:
A61K35/407; A61K35/12; A61P21/00
Other References:
WARITA, H. ET AL.: "Clinical translation of hepatocyte growth factor for amyotrophic lateral sclerosis''.", RINSHO SHINKEIGAKU, vol. 52, 2012, pages 1214 - 1217, XP055340118
KADOYAMA, K. ET AL.: "Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS''.", NEUROSCIENCE RESEARCH, vol. 59, 2007, pages 446 - 456, XP022321346
HENRIQUES, A. ET AL.: "Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?''.", FRONTIERS IN NEUROSCIENCE, vol. 4, no. 32, 2010, pages 1 - 14, XP055340121
KADOYAMA, K. ET AL.: "Hepatocyte growth factor (HGF) attenuates gliosis and motoneuronal degeneration in the brainstem motor nuclei of a transgenic mouse model of ALS''.", NEUROSCIENCE RESEARCH, vol. 59, 2007, pages 446 - 456, XP022321346
HENRIQUES, A. ET AL.: "Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand?''.", FRONTIERS IN NEUROSCIENCE, vol. 4, no. 32, 2010, pages 1 - 14, XP055340121
Attorney, Agent or Firm:
YANG, Boo-Hyun (Chungdong Building1922 Nambusunhwann, Gwanak-gu Seoul 151-832, KR)
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