Title:
COMPOSITION, FOR PREVENTING OR TREATING DRY EYE SYNDROME, CONTAINING POLYETHYLENE GLYCOL AND FLAVONOID NANOCOMPOSITE AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/155773
Kind Code:
A1
Abstract:
The present invention relates to a composition, for preventing or treating dry eye syndrome, containing polyethylene glycol (PEG) and a flavonoid nanocomposite as an active ingredient. In the present invention, a catechin/PEG nanocomposite having increased catechin bioavailability is prepared by means of polyethylene glycol, which is used in a drug delivery system and is a hydrophilic polymer, and catechins which are an antioxidant. An increase in tear generation due to the catechin/PEG nanocomposite, stabilization of corneal epithelial cells, an increase in conjunctival goblet cells and enhanced anti-inflammatory effects in accordance with a PEG dosage are shown in a mouse model with dry eye syndrome. Therefore, the catechin/PEG nanocomposite having the above effects can be utilized as a new biomedical material for treating dry eye syndrome by means of stabilization of a tear film and inflammation inhibition.
Inventors:
YANG JAE WOOK (KR)
LEE HYE SOOK (KR)
LEE YOON JIN (KR)
KIM CHAE EUN (KR)
LEE HAE SHIN (KR)
SHIM WHUI SU (KR)
LEE MOON SUE (KR)
LEE HYE SOOK (KR)
LEE YOON JIN (KR)
KIM CHAE EUN (KR)
LEE HAE SHIN (KR)
SHIM WHUI SU (KR)
LEE MOON SUE (KR)
Application Number:
PCT/KR2017/008332
Publication Date:
August 30, 2018
Filing Date:
August 02, 2017
Export Citation:
Assignee:
UNIV INJE IND ACAD COOP FOUND (KR)
International Classes:
A61K47/60; A61K9/00; A61K31/553; B82Y5/00
Foreign References:
| KR20150139899A | 2015-12-14 | |||
| KR20170007780A | 2017-01-20 | |||
| US20050220753A1 | 2005-10-06 |
Other References:
SHIN, M. ET AL.: "Tannic Acid as a Degradable Mucoadhesive Compound.", ACS BIOMATERIALS SCIENCE & ENGINEERING, vol. 2, 2016, pages 687 - 696, XP055538279
LEE, H. ET AL.: "Therapeutic Efficacy of Nanocomplex of Poly (ethylene glycol) and Catechin for Dry Eye Disease in a Mouse Model", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 58, no. 3, March 2017 (2017-03-01), pages 1682 - 1691, XP055538281
LEE, H. ET AL.: "Therapeutic Efficacy of Nanocomplex of Poly (ethylene glycol) and Catechin for Dry Eye Disease in a Mouse Model", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 58, no. 3, March 2017 (2017-03-01), pages 1682 - 1691, XP055538281
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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