Title:
COMPOSITION FOR PREVENTING AND TREATING MALE INFERTILITY, CONTAINING MIXED HERBAL EXTRACT AS ACTIVE INGREDIENT AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/174636
Kind Code:
A1
Abstract:
The present invention relates to a composition and health functional food for preventing and treating male infertility using a mixed herbal mixture. Through an in vitro sperm mobility promotion effect evaluation method experiment for investigating effects of an herbal extract of Morinda officinalis, cuscuta seed, and/or Allium cepa of the present invention on changes in sperm count and mobility in human semen, it was verified that the samples of the present invention increased sperm mobility. In addition, through an in vivo varicocele animal model evaluation method for investigating effects of the herbal extract on changes in sperm count and mobility in an in vivo varicocele animal model, it was verified that the samples of the present invention increased the sperm count in the semen obtained from spermiducts of a sample-administered group among varicocele-induced groups. Therefore, the herbal extract of the present invention can be usefully used in a pharmaceutical composition, health functional food, and health supplement food for preventing and treating male infertility.
Inventors:
PARK JONG KWAN (KR)
Application Number:
PCT/KR2015/003506
Publication Date:
November 19, 2015
Filing Date:
April 08, 2015
Export Citation:
Assignee:
NAT UNIV CHONBUK IND COOP FOUND (KR)
International Classes:
A61K36/74; A61K36/43; A61K36/8962; A61P15/00
Foreign References:
| KR20130035091A | 2013-04-08 | |||
| KR20070094394A | 2007-09-20 |
Other References:
OH, JAE - SUNG ET AL.: "Administration Duration Dependent Effects of Morindae Radix Extract Solution on Reproductive Capacities in Mice.", JOURNAL OF THE KOREA INSTITUTE OF ORIENTAL MEDICAL DIAGNOSTICS., vol. 27, no. 3, 2006, pages 63 - 76, XP055360568
PARK, JEONG YEOL.: "Effects of Cuscutae Semen on the cAMP-Responsive Element Modulator (CREM) Expression and Sperm Parameters in Infertile Male Mice Induced by Cyclophosphamide.", D OCTORAL THESIS OF DEPARTMENT OF KOREAN MEDICINE OF GRADUATE SCHOOL, February 2011 (2011-02-01), XP008185365
KHAKI, A. ET AL.: "Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat.", FOLIA MORPHOL (WARSZ)., vol. 68, no. 1, 2009, pages 45 - 51, XP055360571
PARK, JEONG YEOL.: "Effects of Cuscutae Semen on the cAMP-Responsive Element Modulator (CREM) Expression and Sperm Parameters in Infertile Male Mice Induced by Cyclophosphamide.", D OCTORAL THESIS OF DEPARTMENT OF KOREAN MEDICINE OF GRADUATE SCHOOL, February 2011 (2011-02-01), XP008185365
KHAKI, A. ET AL.: "Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat.", FOLIA MORPHOL (WARSZ)., vol. 68, no. 1, 2009, pages 45 - 51, XP055360571
Attorney, Agent or Firm:
SHIN, DONG IN (KR)
신동인 (KR)
신동인 (KR)
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