Title:
COMPOSITION FOR PREVENTING OR TREATING RENAL DISEASES, CONTAINING DPP-IV INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2014/208921
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating renal diseases. The composition of the present invention improves lipid metabolism, prevents histological damage including renal fibrosis, alleviates microalbuminuria, and maintains nephrons of renal glomeruli. Therefore, the composition is useful for treating renal diseases.
Inventors:
CHA DAE RYONG (KR)
KANG YOUNG SUN (KR)
CHA JIN JOO (KR)
LEE JI EUN (KR)
KIM HYUN WOOK (KR)
LEE MI HWA (KR)
KIM JUNG EUN (KR)
KIM MI-KYUNG (KR)
SON MOON-HO (KR)
KIM SOON HOE (KR)
KANG YOUNG SUN (KR)
CHA JIN JOO (KR)
LEE JI EUN (KR)
KIM HYUN WOOK (KR)
LEE MI HWA (KR)
KIM JUNG EUN (KR)
KIM MI-KYUNG (KR)
SON MOON-HO (KR)
KIM SOON HOE (KR)
Application Number:
PCT/KR2014/005302
Publication Date:
December 31, 2014
Filing Date:
June 17, 2014
Export Citation:
Assignee:
DONG A ST CO LTD (KR)
UNIV KOREA RES & BUS FOUND (KR)
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K31/4965; A61K31/495; A61P13/12
Foreign References:
| KR20100042786A | 2010-04-27 | |||
| KR20120008093A | 2012-01-25 | |||
| CN101229373A | 2008-07-30 |
Other References:
KIM, HEUNG JAE ET AL.: "Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 21, no. 12, 15 June 2011 (2011-06-15), pages 3809 - 3812, XP028387853
HOCHER, BERTHOLD ET AL.: "Renal and cardiac effects of DPP4 inhibitors-from preclinical development to clinical research", KIDNEY & BLOOD PRESSURE RESEARCH, vol. 36, no. 1, 27 August 2012 (2012-08-27), pages 65 - 84, XP055116556
LEE, JI EUN ET AL.: "Effects of Dipeptidyl Peptidase IV Inhibition on Renal Function in Type 2 Diabetic Mice", 2014 PROCEEDINGS OF THE 34TH ANNUAL SPRING MEETING OF THE KOREAN SOCIETY OF NEPHROLOGY, vol. 2014, no. 1, 23 May 2014 (2014-05-23), pages 172, XP008182715
J. MED. CHEM., vol. 48, 2005, pages 141 - 151
KANG YS ET AL.: "CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice", KIDNEY INT, vol. 78, no. 9, November 2010 (2010-11-01), pages 883 - 894
KANG YS ET AL.: "Visfatin is upregulated in type-2 diabetic rats and targets renal cells", KIDNEY INT., vol. 78, no. 2, July 2010 (2010-07-01), pages 170 - 181
HOCHER, BERTHOLD ET AL.: "Renal and cardiac effects of DPP4 inhibitors-from preclinical development to clinical research", KIDNEY & BLOOD PRESSURE RESEARCH, vol. 36, no. 1, 27 August 2012 (2012-08-27), pages 65 - 84, XP055116556
LEE, JI EUN ET AL.: "Effects of Dipeptidyl Peptidase IV Inhibition on Renal Function in Type 2 Diabetic Mice", 2014 PROCEEDINGS OF THE 34TH ANNUAL SPRING MEETING OF THE KOREAN SOCIETY OF NEPHROLOGY, vol. 2014, no. 1, 23 May 2014 (2014-05-23), pages 172, XP008182715
J. MED. CHEM., vol. 48, 2005, pages 141 - 151
KANG YS ET AL.: "CCR2 antagonism improves insulin resistance, lipid metabolism, and diabetic nephropathy in type 2 diabetic mice", KIDNEY INT, vol. 78, no. 9, November 2010 (2010-11-01), pages 883 - 894
KANG YS ET AL.: "Visfatin is upregulated in type-2 diabetic rats and targets renal cells", KIDNEY INT., vol. 78, no. 2, July 2010 (2010-07-01), pages 170 - 181
Attorney, Agent or Firm:
AHN, So-Young (KR)
안소영 (KR)
안소영 (KR)
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