Title:
COMPOSITION FOR PREVENTING OR TREATING SEPSIS OR SEPTIC SHOCK, COMPRISING ADK PROTEIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2015/163533
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating sepsis or septic shock, the composition comprising, as an active ingredient, adenosine kinase (ADK) protein derived from Mycobacterium tuberculosis. The ADK protein derived from Mycobacterium tuberculosis, according to the present invention, has an effect of inhibiting the binding between LPS and cells due to binding with LPS, and has good therapeutic effects on sepsis, such as an increase in the survival rate of a sepsis animal model, inhibition of inflammatory response in the lung and of cell death in the spleen, etc.
Inventors:
PARK YEONG MIN (KR)
JUNG IN DUK (KR)
SHIN SUNG JAE (KR)
PARK JUNG HEE (KR)
LEE SEUNG JUN (KR)
KANG TAE HEUNG (KR)
SOH BYOUNG YUL (KR)
JUNG IN DUK (KR)
SHIN SUNG JAE (KR)
PARK JUNG HEE (KR)
LEE SEUNG JUN (KR)
KANG TAE HEUNG (KR)
SOH BYOUNG YUL (KR)
Application Number:
PCT/KR2014/006028
Publication Date:
October 29, 2015
Filing Date:
July 04, 2014
Export Citation:
Assignee:
UNIV KONKUK IND COOP CORP (KR)
International Classes:
A61K38/16; A61P11/00; A61P31/04
Other References:
LEE, SEUNG HEON ET AL.: "Protective Efficacy of Recombinant Proteins Adenylate Kinase, Nucleoside Diphosphate Kinase, and Heat-Shock Protein 70 against Mycobacterium Tuberculosis Infection in Mice''.", TUBERCULOSIS AND RESPIRATORY DISEASES, vol. 58, 2005, pages 142 - 152, XP055233422
LEE, SEUNG HEON ET AL.: "Investigation of the Growth Rate Change in Recombinant BCG which was cloned Mycobacterium Tuberculosis Adenylate Kinase Mutation Gene or Human Muscle-type Adenylate Kinase Synthetic Gene", TUBERCULOSIS AND RESPIRATORY DISEASES, vol. 60, 2006, pages 187 - 193, XP055233427
MUNIER-LEHMANN. H. ET AL.: "A new subfamily of short bacterial adenylate kinases with the mycobacterium tuberculosis enzyme as a model: a predictive and experimental study", PROTEINS: STRUCTURE, FUNCTION, AND GENETICS, vol. 36, 1999, pages 238 - 248, XP055233430
MIRON, S. ET AL.: "Structural and Dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity", BIOCHEMISTRY, vol. 43, 2004, pages 67 - 77, XP055233432
BELLINZONI, M. ET AL.: "The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associated mechanism for phosphoryl transfer", PROTEIN SCIENCE, vol. 15, 2006, pages 1481 - 1493, XP055233435
DATABASE Protein 29 August 2013 (2013-08-29), "MULTISPECIES: adenylate kinase [Mycobacterium tuberculosis complex", XP055255172, Database accession no. WP_003403726.1
See also references of EP 2982378A4
LEE, SEUNG HEON ET AL.: "Investigation of the Growth Rate Change in Recombinant BCG which was cloned Mycobacterium Tuberculosis Adenylate Kinase Mutation Gene or Human Muscle-type Adenylate Kinase Synthetic Gene", TUBERCULOSIS AND RESPIRATORY DISEASES, vol. 60, 2006, pages 187 - 193, XP055233427
MUNIER-LEHMANN. H. ET AL.: "A new subfamily of short bacterial adenylate kinases with the mycobacterium tuberculosis enzyme as a model: a predictive and experimental study", PROTEINS: STRUCTURE, FUNCTION, AND GENETICS, vol. 36, 1999, pages 238 - 248, XP055233430
MIRON, S. ET AL.: "Structural and Dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity", BIOCHEMISTRY, vol. 43, 2004, pages 67 - 77, XP055233432
BELLINZONI, M. ET AL.: "The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associated mechanism for phosphoryl transfer", PROTEIN SCIENCE, vol. 15, 2006, pages 1481 - 1493, XP055233435
DATABASE Protein 29 August 2013 (2013-08-29), "MULTISPECIES: adenylate kinase [Mycobacterium tuberculosis complex", XP055255172, Database accession no. WP_003403726.1
See also references of EP 2982378A4
Attorney, Agent or Firm:
KIM, SOON WOONG (KR)
κΉμμ (KR)
κΉμμ (KR)
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