Title:
COMPOSITION FOR PROMOTING STEM CELL ACTIVITY, COMPRISING HISTONE DEACETYLASE INHIBITOR AND PRIMING FACTOR AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2018/088821
Kind Code:
A1
Abstract:
The present invention relates to a composition for promoting stem cell activity, comprising a histone deacetylase inhibitor and a priming factor as active ingredients. When stem cells were treated with a low-concentration histone deacetylase inhibitor and priming factor, the activity of the stem cells significantly improved. In particular, primed MSCs promote a cell movement, colony-forming activity, and anti-inflammatory capability in terms of cell culturing conditions and thereby improve hypertension, inflammatory disease, or immune disease treatment effects and thus are expected to become a useful treatment strategy.
Inventors:
SHIN DONG-MYUNG (KR)
LIM JI SUN (KR)
OH YEON-MOK (KR)
LIM JI SUN (KR)
OH YEON-MOK (KR)
Application Number:
PCT/KR2017/012675
Publication Date:
May 17, 2018
Filing Date:
November 09, 2017
Export Citation:
Assignee:
UNIV ULSAN FOUND IND COOP (KR)
ASAN FOUND (KR)
ASAN FOUND (KR)
International Classes:
C12N5/00; A61K31/166; A61K31/19; A61K31/465; A61K35/28
Domestic Patent References:
| WO2000023567A2 | 2000-04-27 |
Other References:
LIM, J. ET AL.: "Priming with Ceramide-l Phosphate Promotes the Therapeutic Effect of Mesenchymal Stern/stromal Cells on Pulmonary Artery Hypertension", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 473, 2016, pages 35 - 41, XP055493127, DOI: doi:10.1016/j.bbrc.2016.03.046
MARQUEZ-CURTIS, L. A. ET AL.: "Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid", STEM CELLS INT., vol. 2014, 16 March 2014 (2014-03-16), pages 1 - 14, XP055493128
KANG, H. ET AL.: "The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension", STEM CELLS DEV., vol. 24, no. 14, 2015, pages 1658 - 1671, XP055493135
LIM, J. ET AL.: "Valproic Acid Enforces the Priming Effect of Sphingosine-1 Phosphate on Human Mesenchymal Stem Cells", INT. J. MOL. MED., vol. 40, 3 July 2017 (2017-07-03), pages 739 - 747, XP055493143
MARQUEZ-CURTIS, L. A. ET AL.: "Migration, Proliferation, and Differentiation of Cord Blood Mesenchymal Stromal Cells Treated with Histone Deacetylase Inhibitor Valproic Acid", STEM CELLS INT., vol. 2014, 16 March 2014 (2014-03-16), pages 1 - 14, XP055493128
KANG, H. ET AL.: "The Therapeutic Effects of Human Mesenchymal Stem Cells Primed with Sphingosine-1 Phosphate on Pulmonary Artery Hypertension", STEM CELLS DEV., vol. 24, no. 14, 2015, pages 1658 - 1671, XP055493135
LIM, J. ET AL.: "Valproic Acid Enforces the Priming Effect of Sphingosine-1 Phosphate on Human Mesenchymal Stem Cells", INT. J. MOL. MED., vol. 40, 3 July 2017 (2017-07-03), pages 739 - 747, XP055493143
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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