Title:
COMPOSITION FOR REGENERATIVE TREATMENT OF CARTILAGE DAMAGE
Document Type and Number:
WIPO Patent Application WO/2014/200237
Kind Code:
A1
Abstract:
The present invention relates to a composition containing a granulocyte macrophage-colony stimulating factor (GM-CSF) as an active ingredient for regenerative treatment of cartilage damage. More specifically, the GM-CSF is characterized by being at least one selected from the group consisting of a GM-CSF full-length gene, a GM-CSF gene subdomain, proteins expressed by the genes, and cells transformed to express the genes. In addition, the composition is characterized by being administered by treating the transplant at the time of bone marrow transplantation (BMT) or stem cell transplantation. Therefore, the GM-CSF is expected to be applicable as a regenerative treatment agent of damaged cartilage.
Inventors:
MIN BYOUNG HYUN (KR)
PARK SO RA (KR)
CHOI BYUNG HYUNE (KR)
TRUONG MINH DUNG (KR)
PARK SO RA (KR)
CHOI BYUNG HYUNE (KR)
TRUONG MINH DUNG (KR)
Application Number:
PCT/KR2014/005063
Publication Date:
December 18, 2014
Filing Date:
June 10, 2014
Export Citation:
Assignee:
AJOU UNIV IND ACAD COOP FOUND (KR)
International Classes:
A61K48/00; A61K38/19; A61P19/00
Domestic Patent References:
| WO2011060554A1 | 2011-05-26 |
Foreign References:
| KR101270161B1 | 2013-05-31 |
Other References:
QUINTERO M. ET AL.: "Granulocyte-macrophage colony stimulating factor activates proteoglycan, type II collagen, and cAMP production by rat articular chondrocytes through specific binding sites.", J. RHEUMATOL., vol. 28, no. 9, September 2001 (2001-09-01), pages 2075 - 2084
A. MARMOTTI ET AL.: "Human cartilage fragments in a composite scaffold for single-stage cartilage repair: an in vitro study of the chondrocyte migration and the influence of TGF-b1 and G-CSF", KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 21, 10 November 2012 (2012-11-10), pages 1819 - 1833
A. MARMOTTI ET AL.: "Human cartilage fragments in a composite scaffold for single-stage cartilage repair: an in vitro study of the chondrocyte migration and the influence of TGF-b1 and G-CSF", KNEE SURG SPORTS TRAUMATOL ARTHROSC, vol. 21, 10 November 2012 (2012-11-10), pages 1819 - 1833
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
특허법인 태백 (KR)
특허법인 태백 (KR)
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