COMPOSITIONS AND METHODS FOR DECREASING, OR PREVENTING OR REVERSING GAIN OF, SKIN PIGMENTATION IN A MAMMALIAN SUBJECT

WIPO Patent Application WO/2016/164460

A3

The present invention includes compounds, compositions comprising the same, and methods using the compounds and/or compositions therein, for modulating skin pigmentation in a mammalian subject. In certain embodiments, the compounds of the invention treat or prevent skin disorders or diseases associated with hyperpigmentation in the subject. In other embodiments, the compounds of the invention act as antagonist to the non-canonical sex steroid hormone receptor GPRE1 and do not bind to a canonical nuclear estrogen receptor (ER). In yet other embodiments, the compounds of the invention comprise acts as agonists to the non-canonical sex steroid hormone receptor PAQR7 and do not bind to a canonical nuclear progesterone receptor (PR).

JPH09505058	INDUSTRIAL APPLICABILITY: A method for treating cardiac dysfunction and a pharmaceutical composition useful for that purpose.
JP4925074	A pharmaceutical composition comprising mirtazapine and one or more selective serotonin reuptake inhibitors.
JPS6471867	PROPIONIC ACID COMPOUND

RIDKY TODD (US)
NATALE CHRIS (US)

PCT/US2016/026213

November 24, 2016

April 06, 2016

Click for automatic bibliography generation  

UNIV PENNSYLVANIA (US)

A61K31/34; A61K31/343; A61K31/47; A61K31/4704

US20090197939A1	2009-08-06
US20080167334A1	2008-07-10

DATABASE PUBCHEM 22 February 2008 (2008-02-22), XP055331367, Database accession no. 48409626

DOYLE, Kathryn et al. (Centre Square West1500 Market Street, 38th Floo, Philadelphia Pennsylvania, US)

View/Download PDF      PDF Help

Previous Patent: VIDEO CAMERA WITH RATE CONTROL VIDEO COMPRESSION

Next Patent: ASYMMETRIC BEARING WITH FAIL SAFE TAB