Title:
COMPOSITIONS AND METHODS FOR DETERMINING SUSCEPTIBILITY OF HEPATITIS C VIRUS TO ANTI-VIRAL DRUGS
Document Type and Number:
WIPO Patent Application WO2003093492
Kind Code:
A3
Abstract:
The present invention provides methods for determining the susceptibility of a pathogenic flavivirus to anti-viral compounds. This invention also provides methods for determining anti-viral drug susceptibility in a patient infected with a flavivirus. This invention also provides a method for evaluating the biological effectiveness of a candidate anti-viral drug compound. The methods are useful for identifying effective drug regimens for the treatment of flaviviral infections, and identifying and assessing the biological effectiveness of potential therapeutic compounds. Compositions including resistance test vectors and host cells transformed with the resistance test vectors are provided.
Inventors:
PARKIN NEIL T
GAMARNIK ANDREA
GAMARNIK ANDREA
Application Number:
PCT/US2003/013791
Publication Date:
April 01, 2004
Filing Date:
May 05, 2003
Export Citation:
Assignee:
VIROLOGIC INC (US)
International Classes:
C07K14/18; C12N15/51; C12N15/85; C12N15/86; C12Q1/68; C12Q1/70; (IPC1-7): C12Q1/68; C12Q1/70; C12N15/51
Domestic Patent References:
| WO1999006597A1 | 1999-02-11 |
Foreign References:
| US6242187B1 | 2001-06-05 | |||
| US20020034732A1 | 2002-03-21 | |||
| US5874565A | 1999-02-23 |
Other References:
BLIGHT K.J. ET AL.: "Efficient initiation of HCV RNA replication in cell culture", SCIENCE, vol. 290, December 2000 (2000-12-01), pages 1972 - 1974, XP002951271
CHUNG R.T. ET AL.: "Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 17, 14 August 2001 (2001-08-14), pages 9847 - 9852, XP002968094
CHUNG R.T. ET AL.: "Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system", PROC. NATL. ACAD. SCI. USA, vol. 98, no. 17, 14 August 2001 (2001-08-14), pages 9847 - 9852, XP002968094
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