Title:
COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF BONE FRACTURES AND DISORDERS
Document Type and Number:
WIPO Patent Application WO/2015/189345
Kind Code:
A3
Abstract:
The present invention relates to the therapy, prophylaxis and diagnosis of disorders that are associated with aberrant bone mineral density, in particular osteoporosis; wherein the level of selected micro RNAs in samples of patients are detected and wherein an increase or decrease of said level compared to the level of healthy indivduals is indicative of the disorder.
Inventors:
GRILLARI JOHANNES (AT)
GRILLARI REGINA (AT)
HACKL MATTHIAS (AT)
SCHRAML ELISABETH (AT)
WEILNER SYLVIA (AT)
GRILLARI REGINA (AT)
HACKL MATTHIAS (AT)
SCHRAML ELISABETH (AT)
WEILNER SYLVIA (AT)
Application Number:
PCT/EP2015/063091
Publication Date:
February 04, 2016
Filing Date:
June 11, 2015
Export Citation:
Assignee:
UNIVERSITÄT FÜR BODENKULTUR WIEN (AT)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2007023306A1 | 2007-03-01 | |||
| WO2013155085A1 | 2013-10-17 | |||
| WO2011144761A1 | 2011-11-24 |
Other References:
YANG WANG ET AL: "MiR-133a in Human Circulating Monocytes: A Potential Biomarker Associated with Postmenopausal Osteoporosis", PLOS ONE, vol. 7, no. 4, 10 April 2012 (2012-04-10), pages e34641, XP055141362, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0034641
SEELIGER C ET AL: "Identification of freely circulating mirnas in the serum, in bone tissue and in cells related to bone homeostasis that are associated with osteoporotic fractures", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, no. Suppl. 1, Sp. Iss. SI, 1 June 2014 (2014-06-01), & EUROPEAN-CHAPTER MEETING OF TISSUE-ENGINEERING-AND-REGENERATIVE-MEDICINE-SOCIETY (TERMIS); GENOVA, ITALY; JUNE 10 -13, 2014, pages 270, XP008172201
SEELIGER C ET AL: "Identification of freely circulating mirnas in the serum, in bone tissue and in cells related to bone homeostasis that are associated with osteoporotic fractures", JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, vol. 8, no. Suppl. 1, Sp. Iss. SI, 1 June 2014 (2014-06-01), & EUROPEAN-CHAPTER MEETING OF TISSUE-ENGINEERING-AND-REGENERATIVE-MEDICINE-SOCIETY (TERMIS); GENOVA, ITALY; JUNE 10 -13, 2014, pages 270, XP008172201
Attorney, Agent or Firm:
LOIDL, Manuela et al. (Donau-City-Straße 11, Vienna, AT)
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