Title:
COMPOSITIONS AND METHODS RELATING TO LUNG SPECIFIC GENES AND PROTEINS
Document Type and Number:
WIPO Patent Application WO2002077236
Kind Code:
A3
Abstract:
The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic lung cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating lung cancer and non-cancerous disease states in lung, identifying lung tissue, monitoring and identifying and/or designing agonists and antagonists of polypetides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered lung tissue for treatment and research.
Inventors:
RECIPON HERVE (US)
SUN YONGMING (US)
CHEN SEI-YU (US)
LIU CHENGHUA (US)
TURNER LEAH R (US)
SUN YONGMING (US)
CHEN SEI-YU (US)
LIU CHENGHUA (US)
TURNER LEAH R (US)
Application Number:
PCT/US2001/050385
Publication Date:
August 21, 2003
Filing Date:
October 26, 2001
Export Citation:
Assignee:
DIADEXUS INC (US)
RECIPON HERVE (US)
SUN YONGMING (US)
CHEN SEI-YU (US)
LIU CHENGHUA (US)
TURNER LEAH R (US)
RECIPON HERVE (US)
SUN YONGMING (US)
CHEN SEI-YU (US)
LIU CHENGHUA (US)
TURNER LEAH R (US)
International Classes:
A61K49/00; A61P35/04; C07K14/47; C12N1/21; C12N15/12; A61K38/00; A61K39/00; A61K48/00; (IPC1-7): C12N15/12; C12N15/63; C12N1/21; C12N5/10; C07K14/47; C07K16/18; C12Q1/68; G01N33/68; A61K38/17; A61K39/395; A61K31/7088; A61K31/713; A61K48/00; A61P35/04
Domestic Patent References:
| WO1999060160A1 | 1999-11-25 |
Other References:
DATABASE EMBL [online] 1 February 1999 (1999-02-01), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT: "ql80h12.x1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:1878695 3', mRNA sequence", XP002231994, retrieved from EBI accession no. AI288478
DATABASE EMBL [online] 3 March 2000 (2000-03-03), HILLIER L. ET AL.: "zv97f02.s1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:767739 3', mRNA sequence", XP002231995, retrieved from EBI accession no. AA418028
DATABASE EMBL [online] 15 November 1999 (1999-11-15), BIRREN B ET AL.: "Homo sapiens chromosome 8, clone RP11-17A4, complete sequence", XP002231996, retrieved from EBI accession no. AC013644
WANG T ET AL: "IDENTIFICATION OF GENES DIFFERENTIALLY OVER-EXPRESSED IN LUNG SQUAMOUS CELL CARCINOMA USING COMBINATION OF CDNA SUBTRACTION AND MICROARRAY ANALYSIS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 19, no. 12, 16 March 2000 (2000-03-16), pages 1519 - 1528, XP000951444, ISSN: 0950-9232
SUNDAY M E: "DIFFERENTIAL DISPLAY RT-PCR FOR IDENTIFYING NOVEL GENE EXPRESSION IN THE LUNG", AMERICAN JOURNAL OF PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, vol. 269, no. 3, 1995, pages L273 - L284, XP008013304, ISSN: 0002-9513
DATABASE EMBL [online] 3 March 2000 (2000-03-03), HILLIER L. ET AL.: "zv97f02.s1 Soares_NhHMPu_S1 Homo sapiens cDNA clone IMAGE:767739 3', mRNA sequence", XP002231995, retrieved from EBI accession no. AA418028
DATABASE EMBL [online] 15 November 1999 (1999-11-15), BIRREN B ET AL.: "Homo sapiens chromosome 8, clone RP11-17A4, complete sequence", XP002231996, retrieved from EBI accession no. AC013644
WANG T ET AL: "IDENTIFICATION OF GENES DIFFERENTIALLY OVER-EXPRESSED IN LUNG SQUAMOUS CELL CARCINOMA USING COMBINATION OF CDNA SUBTRACTION AND MICROARRAY ANALYSIS", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 19, no. 12, 16 March 2000 (2000-03-16), pages 1519 - 1528, XP000951444, ISSN: 0950-9232
SUNDAY M E: "DIFFERENTIAL DISPLAY RT-PCR FOR IDENTIFYING NOVEL GENE EXPRESSION IN THE LUNG", AMERICAN JOURNAL OF PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, BETHESDA, MD, US, vol. 269, no. 3, 1995, pages L273 - L284, XP008013304, ISSN: 0002-9513
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