Title:
COMPOSITIONS AND METHODS RELATING TO OVARY SPECIFIC GENES AND PROTEINS
Document Type and Number:
WIPO Patent Application WO2003020897
Kind Code:
A3
Abstract:
The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
Inventors:
SUN YONGMING (US)
LIU CHENGHUA (US)
SALCEDA SUSANA (US)
LIU CHENGHUA (US)
SALCEDA SUSANA (US)
Application Number:
PCT/US2002/027727
Publication Date:
January 08, 2004
Filing Date:
August 29, 2002
Export Citation:
Assignee:
DIADEXUS INC (US)
SUN YONGMING (US)
LIU CHENGHUA (US)
SALCEDA SUSANA (US)
SUN YONGMING (US)
LIU CHENGHUA (US)
SALCEDA SUSANA (US)
International Classes:
C07K14/47; C12N1/21; C12N15/12; (IPC1-7): C12N15/12; C07K14/435; C12N1/21; C12N5/10; C12N15/63; G01N33/48
Other References:
DATABASE GENBANK [online] DUCLERT ET AL.: "New nuclic acids encoding human secreted proteins - obtained from cDNA libraries prepared from kidney, fetal kidney, dystrophic muscle, muscle and heart tissue", XP002965910, accession no. EMBL Database accession no. (AAX40981)
DATABASE GENBANK [online] EDWARDS J. ET AL.: "New nucleic acid that is a 5' expressed sequence tag (5' EST) for obtaining cDNAs and genomic DNAs that correspond to 5' ESTs and for diagnostic, forensic, gene therapy and chromosome mapping procedures", XP002965911, accession no. EMBL Database accession no. (AAC26415)
"Recombinant DNA Second Edition", 1994, FREEMAN W.H. & CO., NEW YORK, article WATSON ET AL.: "Methods of creating recombinant DNA molecules", pages: 63 - 77, XP002929767
DATABASE GENBANK [online] EDWARDS J. ET AL.: "New nucleic acid that is a 5' expressed sequence tag (5' EST) for obtaining cDNAs and genomic DNAs that correspond to 5' ESTs and for diagnostic, forensic, gene therapy and chromosome mapping procedures", XP002965911, accession no. EMBL Database accession no. (AAC26415)
"Recombinant DNA Second Edition", 1994, FREEMAN W.H. & CO., NEW YORK, article WATSON ET AL.: "Methods of creating recombinant DNA molecules", pages: 63 - 77, XP002929767
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