Title:
COMPOSITIONS AND METHODS FOR TRANSEPITHELIAL TRANSPORT OF MEMBRANE-BOUNDED VESICLES AND VIRIONS
Document Type and Number:
WIPO Patent Application WO2002083840
Kind Code:
A3
Abstract:
The invention provides compositions and methods for the delivery of membrane-bounded vesicles such as liposomes and the virions of enveloped viruses, as well as nucleocapsid virions into, through, out of and around, epithelial cells and layers and, optionally, to an intracellular location. Such membrane-bounded vesicles and virions are used to deliver therapeutic agents in general. Certain aspects of the invention are particularly well suited for the delivery of therapeutic nucleic acids, i.e., gene therapy.
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Inventors:
SHERIDAN PHILIP L (US)
HOUSTON LOU L (US)
HOUSTON LOU L (US)
Application Number:
PCT/US2002/010647
Publication Date:
March 13, 2003
Filing Date:
April 03, 2002
Export Citation:
Assignee:
ARIZEKE PHARMACEUTICALS INC (US)
SHERIDAN PHILIP L (US)
HOUSTON LOU L (US)
SHERIDAN PHILIP L (US)
HOUSTON LOU L (US)
International Classes:
A61K9/127; A61K47/48; A61K48/00; C12N15/86; C12N15/867; C12N15/88; C12P21/08; (IPC1-7): C12P21/08; A61K48/00; C12N15/00; C12N15/86; C12N15/88
Foreign References:
| US6072041A | 2000-06-06 | |||
| US5869331A | 1999-02-09 |
Other References:
MARIN M. ET AL.: "Targeted infection of human cells via major histocompatibility complex class I molecules by moloney murine leukemia virus-derived viruses displaying single-chain antibody fragment-envelope fusion proteins", J. VIROL., vol. 70, no. 5, May 1996 (1996-05-01), pages 2957 - 2962, XP000615448
CHU T.T. ET AL.: "Toward highly efficient cell-type specific gene transfer with retroviral vectors displaying single-chain antibodies", J. VIROL., vol. 71, no. 1, January 1997 (1997-01-01), pages 720 - 725, XP002190551
MARTIN F. ET AL.: "Retrovirus targeting by tropism restriction to melanoma cells", J. VIROL., vol. 73, no. 8, August 1999 (1999-08-01), pages 6923 - 6929, XP002959695
CHU T.T. ET AL.: "Toward highly efficient cell-type specific gene transfer with retroviral vectors displaying single-chain antibodies", J. VIROL., vol. 71, no. 1, January 1997 (1997-01-01), pages 720 - 725, XP002190551
MARTIN F. ET AL.: "Retrovirus targeting by tropism restriction to melanoma cells", J. VIROL., vol. 73, no. 8, August 1999 (1999-08-01), pages 6923 - 6929, XP002959695
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