Title:
COMPOSITIONS AND METHODS FOR TREATING CANCER WITH AN ONCOLYTIC VIRAL AGENT
Document Type and Number:
WIPO Patent Application WO2003092579
Kind Code:
A3
Abstract:
The invention discloses lytic viruses as anti-neoplastic agents for specifically replicating and lysing tumor cells. According to the present invention, the agents preferably include E1A deficient adenoviral vectors, exemplified by Ad.HIL6gfp, encoding an IL-6/sIL-6R complex, HIL-6, which is able to replicate, produce cytotoxic effects, and kill tumor cells in the absence of either E1A or exogenous IL-6 protein. These viral agents have utility as therapeutic vehicles for treating cancers of various types either as a single agent, or applied in combination with other therapeutic strategies.
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Inventors:
AXELROD JONATHAN H (IL)
GALUN EITHAN (IL)
ROSE-JOHN STEFAN (DE)
GALUN EITHAN (IL)
ROSE-JOHN STEFAN (DE)
Application Number:
PCT/IL2003/000343
Publication Date:
January 08, 2004
Filing Date:
April 29, 2003
Export Citation:
Assignee:
HADASIT MED RES SERVICE (IL)
AXELROD JONATHAN H (IL)
GALUN EITHAN (IL)
ROSE-JOHN STEFAN (DE)
AXELROD JONATHAN H (IL)
GALUN EITHAN (IL)
ROSE-JOHN STEFAN (DE)
International Classes:
A61K35/76; A61K35/761; A61K38/20; A61K48/00; C12N15/861; (IPC1-7): A61K35/00; A61K48/00
Domestic Patent References:
| WO1999002552A2 | 1999-01-21 |
Foreign References:
| US5919763A | 1999-07-06 | |||
| US5902576A | 1999-05-11 |
Other References:
RUSSELL W.C.: "Update on adenovirus and its vectors", JOURNAL OF GENERAL VIROLOGY, vol. 81, 2000, pages 2573 - 2604, XP002247418
RANCOURT C. ET AL.: "Interleukin-6 modulated conditionally replicative adenovirus as an antitumor/cytotoxic agent for cancer therapy", CLINICAL CANCER RESEARCH, vol. 5, January 1999 (1999-01-01), pages 43 - 50, XP002969154
RANCOURT C. ET AL.: "Interleukin-6 modulated conditionally replicative adenovirus as an antitumor/cytotoxic agent for cancer therapy", CLINICAL CANCER RESEARCH, vol. 5, January 1999 (1999-01-01), pages 43 - 50, XP002969154
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