Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR
Document Type and Number:
WIPO Patent Application WO1999035170
Kind Code:
A9
Abstract:
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment.
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Inventors:
BOTSTEIN DAVID (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
LAWRENCE DAVID A (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
LAWRENCE DAVID A (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
Application Number:
PCT/US1999/000106
Publication Date:
March 09, 2000
Filing Date:
January 05, 1999
Export Citation:
Assignee:
GENENTECH INC (US)
BOTSTEIN DAVID (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
LAWRENCE DAVID A (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
BOTSTEIN DAVID (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
LAWRENCE DAVID A (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
International Classes:
C07K14/47; (IPC1-7): C07K16/30; A61K39/395; G01N33/574; G01N33/577
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