Title:
COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMORS
Document Type and Number:
WIPO Patent Application WO2000015666
Kind Code:
A3
Abstract:
The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act as predictors of the prognosis of tumor treatment.
Inventors:
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
BOTSTEIN DAVID (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
BOTSTEIN DAVID (US)
Application Number:
PCT/US1999/020594
Publication Date:
November 23, 2000
Filing Date:
September 08, 1999
Export Citation:
Assignee:
GENENTECH INC (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
BOTSTEIN DAVID (US)
GODDARD AUDREY (US)
GURNEY AUSTIN L (US)
HILLAN KENNETH J (US)
ROY MARGARET ANN (US)
WOOD WILLIAM I (US)
BOTSTEIN DAVID (US)
International Classes:
A61K31/711; A61K39/395; A61K45/00; A61K48/00; A61P35/00; C07K14/47; C07K16/00; C07K16/18; C07K16/22; C07K16/28; C07K16/32; G01N33/50; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N5/16; C12N15/09; C12N15/11; C12N15/12; C12N15/13; C12N15/63; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/53; G01N33/574; G01N33/577; C12N; (IPC1-7): C07K16/18; C07K16/22; C07K16/28; A61K39/395; G01N33/53; G01N33/574; C12Q1/68; C12N5/16; C12N15/11; C12N15/12; C12N15/13; C12N15/63
Domestic Patent References:
| WO1997025349A1 | 1997-07-17 | |||
| WO1999014327A2 | 1999-03-25 | |||
| WO1999014328A2 | 1999-03-25 |
Other References:
TANAKA A ET AL: "High frequency of fibroblast growth factor ( FGF ) 8 expression in clinical prostate cancers and breast tissues, immunohistochemically demonstrated by a newly established neutralizing monoclonal antibody against FGF 8.", CANCER RESEARCH, (1998 MAY 15) 58 (10) 2053-6., XP000887327
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