Title:
COMPOUND FOR ENHANCING COUPLING OF TRPV4-KCA2.3 COMPLEX AND ANTIHYPERTENSIVE APPLICATIONS OF COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/184274
Kind Code:
A1
Abstract:
Provided in the present application are a compound for enhancing the spatial coupling of endothelial ion channel complex TRPV4-KCa2.3 and antihypertensive applications of the compound.
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Inventors:
MA XIN (CN)
HE DONGXU (CN)
TANG CHUNLEI (CN)
ZHANG PENG (CN)
CHEN ZHEN (CN)
CAI YANFEI (CN)
HE DONGXU (CN)
TANG CHUNLEI (CN)
ZHANG PENG (CN)
CHEN ZHEN (CN)
CAI YANFEI (CN)
Application Number:
PCT/CN2017/084079
Publication Date:
October 11, 2018
Filing Date:
May 12, 2017
Export Citation:
Assignee:
UNIV JIANGNAN (CN)
International Classes:
C07D239/88; A61K31/498; A61P9/12
Foreign References:
| CN101400672A | 2009-04-01 |
Other References:
MA XIN: "The Function of TRPV4-SKCa Ion Tunnel Complex in the Arteriole Flow and Blood Pressure Regulation", JOURNAL OF NINGXIA MEDICAL UNIVERSITY, vol. 33, 31 August 2011 (2011-08-31), pages 181, XP009515530
SUN, CHUNYUAN ET AL.: "High Salt Diet Enhances the Physical Coupling between TRPV4 and cPLA2", CHINESE PHARMACOLOGICAL BULLETIN, vol. 32, no. 12, 31 December 2016 (2016-12-31), pages 1718 - 1723, XP009515501, ISSN: 1001-1978
SUN, CHUNYUAN ET AL.: "High Salt Diet Enhances the Physical Coupling between TRPV4 and cPLA2", CHINESE PHARMACOLOGICAL BULLETIN, vol. 32, no. 12, 31 December 2016 (2016-12-31), pages 1718 - 1723, XP009515501, ISSN: 1001-1978
Attorney, Agent or Firm:
WUXI HUAYUAN PATENT AND TRADEMARK AGENCY (GENERAL PARTNERSHIP) (CN)
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