Title:
COMPOUND HAVING ANTI-TUMOUR EFFECT AND PREPARATION METHOD AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/128981
Kind Code:
A1
Abstract:
Provided are a compound (LQC-C) with a structure as shown by formula (I) and a preparation method thereof and a use thereof in preparing anti-tumour drugs. The compound has a significant activity in inhibiting the growth of tumour cell lines (HepG-2, HT-29, Hela, BGC-823 and A549), but is less toxic to normal human liver cell (L02) lines, wherein the anti-proliferative activity of the compound on human colon cancer cell line HT-29, human cervical carcinoma cell line Hela and human lung cancer cell line A549 is better than that of the positive drug cisplatin; however, the cell toxicity thereof on normal human liver cell L02 is significantly lower than that of the positive drug cisplatin.
Inventors:
LEI HAIMIN (CN)
WANG PENGLONG (CN)
XU BING (CN)
XIONG LEI (CN)
GONG JOHN (CN)
LIN YIHUI (CN)
WANG PENGLONG (CN)
XU BING (CN)
XIONG LEI (CN)
GONG JOHN (CN)
LIN YIHUI (CN)
Application Number:
PCT/CN2017/071276
Publication Date:
August 03, 2017
Filing Date:
January 16, 2017
Export Citation:
Assignee:
3D MEDICINES (SICHUAN) CO LTD (CN)
International Classes:
C07J63/00; A61K31/58; A61P35/00
Domestic Patent References:
| WO2002016395A1 | 2002-02-28 |
Foreign References:
| CN102675401A | 2012-09-19 |
Other References:
XU, BING: "A Series of New Ligustrazine-Triterpenes Derivatives as Anti- Tumor Agents: Design, Synthesis, and Biological Evaluation", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, no. 9, 2 September 2015 (2015-09-02), pages 21035 - 21055, XP055598469, ISSN: 1422-0067
BILDZIUKEVICH, ULADZIMIR: "Polyamine derivatives of betulinic acid and β-sitosterol: A comparative investiga", STEROIDS, vol. 100, 8 May 2008 (2008-05-08), pages 27 - 35, XP029135559, ISSN: 0039-128X
XU, KUO: "Synthesis and biological evaluation of T- OA analogues as the cytotoxic agents", RESEARCH ON CHEMICAL INTERMEDIATES : AN INTERNAT. JOURNAL, vol. 41, no. 9, 22 July 2014 (2014-07-22), pages 6257 - 6269, XP035524937, DOI: doi:10.1007/s11164-014-1737-z
LI, DAN ET AL.: "Recent Advances of Betulinic Acid and Its Derivatives", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 28, no. 3, 31 December 2004 (2004-12-31), pages 120 - 125
BILDZIUKEVICH, ULADZIMIR: "Polyamine derivatives of betulinic acid and β-sitosterol: A comparative investiga", STEROIDS, vol. 100, 8 May 2008 (2008-05-08), pages 27 - 35, XP029135559, ISSN: 0039-128X
XU, KUO: "Synthesis and biological evaluation of T- OA analogues as the cytotoxic agents", RESEARCH ON CHEMICAL INTERMEDIATES : AN INTERNAT. JOURNAL, vol. 41, no. 9, 22 July 2014 (2014-07-22), pages 6257 - 6269, XP035524937, DOI: doi:10.1007/s11164-014-1737-z
LI, DAN ET AL.: "Recent Advances of Betulinic Acid and Its Derivatives", PROGRESS IN PHARMACEUTICAL SCIENCES, vol. 28, no. 3, 31 December 2004 (2004-12-31), pages 120 - 125
Attorney, Agent or Firm:
HYLANDS LAW FIRM (CN)
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