Title:
COMPOUND HAVING INHIBITORY ACTIVITY AGAINST DIACYLGLYCEROL KINASE α AND/OR ζ, AND PHARMACEUTICAL USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/053650
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a compound having inhibitory activity against DGK α and/or ζ. As a result of diligent study, the inventors of the present invention found, as a substance that can solve the above problem, a compound which has inhibitory activity against DGK α and/or ζ and which is represented by general formula (IY) [where all symbols in the formula have the same meaning as set forth in the specification]. A compound according to the present invention, which is represented by general formula (IY), has inhibitory activity against DGK α and/or ζ, and thus can be used as an active ingredient in an agent for inhibiting the progression of, inhibiting the recurrence of, and/or for treating cancer or infectious diseases, for example.
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Inventors:
YAMAMOTO SHINGO (JP)
KOUNO HIROSHI (JP)
OTSUKI KAZUHIRO (JP)
TAKAI SHIGEYUKI (JP)
SHINOZAKI MAKIKO (JP)
DOUKI KAZUYA (JP)
KOUNO HIROSHI (JP)
OTSUKI KAZUHIRO (JP)
TAKAI SHIGEYUKI (JP)
SHINOZAKI MAKIKO (JP)
DOUKI KAZUYA (JP)
Application Number:
PCT/JP2023/032418
Publication Date:
March 14, 2024
Filing Date:
September 05, 2023
Export Citation:
Assignee:
ONO PHARMACEUTICAL CO (JP)
International Classes:
C07D519/00; A61K31/4545; A61K31/4985; A61K31/522; A61K31/5377; A61P31/00; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| WO2021105117A1 | 2021-06-03 | |||
| WO2012005227A1 | 2012-01-12 |
Other References:
SAÏDANI NADIA, BOTTÉ CYRILLE Y., DELIGNY MICHAEL, BONNEAU ANNE-LAURE, READER JANETTE, LASSELIN RONALD, MERER GOULVEN, NIEPCERON AL: "Discovery of Compounds Blocking the Proliferation of Toxoplasma gondii and Plasmodium falciparum in a Chemical Space Based on Piperidinyl-Benzimidazolone Analogs", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 58, no. 5, 1 May 2014 (2014-05-01), US , pages 2586 - 2597, XP093147816, ISSN: 0066-4804, DOI: 10.1128/AAC.01445-13
HARABUCHI SHOHEI, KHAN OMAR, BASSIRI HAMID, YOSHIDA TAKU, OKADA YOHEI, TAKIZAWA MASAOMI, IKEDA OSAMU, KATADA AKIHIRO, KAMBAYASHI T: "Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8+ T cell responses during chronic viral infection", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 13, Lausanne, CH , XP093147819, ISSN: 1664-3224, DOI: 10.3389/fimmu.2022.1032113
HARABUCHI SHOHEI, KHAN OMAR, BASSIRI HAMID, YOSHIDA TAKU, OKADA YOHEI, TAKIZAWA MASAOMI, IKEDA OSAMU, KATADA AKIHIRO, KAMBAYASHI T: "Manipulation of diacylglycerol and ERK-mediated signaling differentially controls CD8+ T cell responses during chronic viral infection", FRONTIERS IN IMMUNOLOGY, FRONTIERS MEDIA, LAUSANNE, CH, vol. 13, Lausanne, CH , XP093147819, ISSN: 1664-3224, DOI: 10.3389/fimmu.2022.1032113
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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