Title:
COMPOUND FOR INHIBITING PROGRAMMED CELL DEATH AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/228413
Kind Code:
A1
Abstract:
Disclosed in the present invention are an RIPK1 inhibitor for inhibiting programmed cell death and a preparation method therefor. The RIPK1 inhibitor of the present invention is as represented by general formula I, wherein X, Y, Z, L, R1, R2, R3, R4, a ring A, a ring B, and n are as shown in the description and claims. Further disclosed in the present invention are a preparation method of general formula I and an activity test result of general formula I for inhibiting programmed cell death and RIPK1. The compound of general formula I of the present invention can be used for preparing a drug for the treatment and prevention of inflammatory and degenerative diseases.
Inventors:
WANG ZHAOYIN (CN)
CAO JINRUI (CN)
CAO JINRUI (CN)
Application Number:
PCT/CN2022/089186
Publication Date:
November 03, 2022
Filing Date:
April 26, 2022
Export Citation:
Assignee:
SHANGHAI INST ORGANIC CHEMISTRY CAS (CN)
International Classes:
C07D267/14; A61P1/00; A61P1/02; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P9/10; A61P11/06; A61P15/14; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P19/08; A61P25/00; A61P25/14; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/02; A61P37/06; C07D223/16; C07D281/10; C07D401/06; C07D409/12; C07D413/06; C07D413/12; C07D413/14; C07D417/06; C07D417/12; C07D417/14; C07D495/04; C07D498/04; C07D513/04
Domestic Patent References:
| WO2021029632A1 | 2021-02-18 |
Foreign References:
| CN105121432A | 2015-12-02 | |||
| CN106573006A | 2017-04-19 | |||
| CN109843886A | 2019-06-04 |
Attorney, Agent or Firm:
XU&PARTNERS, LLC. (CN)
Download PDF:
Previous Patent: PHOTOGRAPHING METHOD, APPARATUS, AND ELECTRONIC DEVICE
Next Patent: PAGING METHOD, COMMUNICATION APPARATUS, AND SYSTEM
Next Patent: PAGING METHOD, COMMUNICATION APPARATUS, AND SYSTEM