Title:
COMPOUND ISOLATED FROM ANTARCTIC-DERIVED FUNGAL STRAIN ACREMONIUM SP. SF-7394 AND ANTI-INFLAMMATORY, ANTI-CANCER OR ANTI-DIABETIC COMPOSITION COMPRISING SAME
Document Type and Number:
WIPO Patent Application WO/2022/092970
Kind Code:
A1
Abstract:
The present invention relates to a compound isolated from Antarctica-derived fungi and a composition comprising same, and more particularly, to a novel compound isolated from Acremonium sp. SF-7394, an anti-inflammatory, anti-cancer or anti-diabetes pharmaceutical composition comprising the compound, a food for ameliorating inflammation, cancer or diabetes, and a method for isolating the compound. According to the present invention, the composition comprising the compound isolated from Antarctic-derived fungal strain Acremonium sp. SF-7394 suppresses the expression of PTP1B and, as a material derived from a natural product, has a low possibility of safety and side effects-related problems, and thus can be usefully used for the prevention or treatment of inflammatory diseases, cancer or diabetes.
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Inventors:
YIM JOUNG HAN (KR)
KIM IL-CHAN (KR)
HAN SE JONG (KR)
OH HYUN CHEOL (KR)
SOHN JAE HAK (KR)
KIM YOUN-CHUL (KR)
LEE DONGHO (KR)
KIM IL-CHAN (KR)
HAN SE JONG (KR)
OH HYUN CHEOL (KR)
SOHN JAE HAK (KR)
KIM YOUN-CHUL (KR)
LEE DONGHO (KR)
Application Number:
PCT/KR2021/015580
Publication Date:
May 05, 2022
Filing Date:
November 01, 2021
Export Citation:
Assignee:
KOREA INSTITUTE OF OCEAN SCIENCE ＆ TECH (KR)
International Classes:
C07C31/13; A61K31/045; A61K31/085; A61K31/7042; A61P3/10; A61P29/00; A61P35/00; C07C43/205; C07H15/24; C12N1/14
Foreign References:
| KR20010062501A | 2001-07-07 | |||
| CN102229595A | 2011-11-02 | |||
| CN101979366A | 2011-02-23 |
Other References:
ZHAO BING TIAN; NGUYEN DUC HUNG; LE DUC DAT; CHOI JAE SUE; MIN BYUNG SUN; WOO MI HEE: "Protein tyrosine phosphatase 1B inhibitors from natural sources", ARCHIVES OF PHARMACAL RESEARCH, NATL. FISHERIES UNIVERSITY , PUSAN, KR, vol. 41, no. 2, 6 December 2017 (2017-12-06), KR , pages 130 - 161, XP037084935, ISSN: 0253-6269, DOI: 10.1007/s12272-017-0997-8
TRISCHMAN JACQUELINE A., JENSEN PAUL R., FENICAL WILLIAM: "Guaymasol and epiguaymasol: aromatic triols from a deep-sea Bacillus isolate", NATURAL PRODUCT LETTERS, vol. 11, no. 4, 1 April 1998 (1998-04-01), CH , pages 279 - 284, XP009536175, ISSN: 1057-5634, DOI: 10.1080/10575639808044960
KIM HYE JIN, LI XIAO-JUN, KIM DONG-CHEOL, KIM TAI KYOUNG, SOHN JAE HAK, KWON HAEUN, LEE DONGHO, KIM YOUN-CHUL, YIM JOUNG HAN, OH H: "PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394", MOLECULES, vol. 26, no. 18, 10 September 2021 (2021-09-10), pages 5505, XP055926457, ISSN: 1420-3049, DOI: 10.3390/molecules26185505
TRISCHMAN JACQUELINE A., JENSEN PAUL R., FENICAL WILLIAM: "Guaymasol and epiguaymasol: aromatic triols from a deep-sea Bacillus isolate", NATURAL PRODUCT LETTERS, vol. 11, no. 4, 1 April 1998 (1998-04-01), CH , pages 279 - 284, XP009536175, ISSN: 1057-5634, DOI: 10.1080/10575639808044960
KIM HYE JIN, LI XIAO-JUN, KIM DONG-CHEOL, KIM TAI KYOUNG, SOHN JAE HAK, KWON HAEUN, LEE DONGHO, KIM YOUN-CHUL, YIM JOUNG HAN, OH H: "PTP1B Inhibitory Secondary Metabolites from an Antarctic Fungal Strain Acremonium sp. SF-7394", MOLECULES, vol. 26, no. 18, 10 September 2021 (2021-09-10), pages 5505, XP055926457, ISSN: 1420-3049, DOI: 10.3390/molecules26185505
Attorney, Agent or Firm:
LEE, Cheo Young et al. (KR)
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