Title:
COMPOUND SERVING AS PDGF RECEPTOR KINASE INHIBITOR, AND COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2021/117846
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a compound having an inhibitory activity against a PDGF receptor kinase. The present invention includes, for example, a compound represented by formula [1] or a pharmaceutically acceptable salt of the compound, or a solvate of the compound. The compound of the present invention has an inhibitory activity against a PDGF receptor kinase. Due to the inhibitory activity thereof against a PDGF receptor kinase, the compound of the present invention is useful as a therapeutic agent for respiratory diseases, cancer, smooth muscle proliferative diseases, vascular proliferative diseases, autoimmune/inflammatory diseases, metabolic diseases, vascular obstructive diseases and the like.
Inventors:
ASADA JUNSHI (JP)
HARUTA YOSHINARI (JP)
YAKUSHIJI HIROYUKI (JP)
TANAKA TORU (JP)
KURAMOTO KAZUYA (JP)
KOSUGI KEIJI (JP)
FUCHIKAMI CHIAKI (JP)
HARUTA YOSHINARI (JP)
YAKUSHIJI HIROYUKI (JP)
TANAKA TORU (JP)
KURAMOTO KAZUYA (JP)
KOSUGI KEIJI (JP)
FUCHIKAMI CHIAKI (JP)
Application Number:
PCT/JP2020/046201
Publication Date:
June 17, 2021
Filing Date:
December 11, 2020
Export Citation:
Assignee:
NIPPON SHINYAKU CO LTD (JP)
International Classes:
A61P9/00; A61K31/421; A61K31/426; A61K31/429; A61K31/4365; A61K31/437; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4418; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/47; A61K31/4965; A61K31/5025; A61K31/505; A61K31/506; A61K31/517; A61K31/519; A61K31/5377; A61K31/5383; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P11/06; A61P11/08; A61P17/00; A61P27/02; A61P35/00; A61P35/02; A61P43/00; C07D213/54; C07D213/61; C07D213/73; C07D213/81; C07D215/12; C07D239/14; C07D239/74; C07D241/12; C07D241/20; C07D263/34; C07D277/56; C07D401/04; C07D405/04; C07D409/04; C07D471/04; C07D487/04; C07D495/04; C07D498/04; C07D513/04
Domestic Patent References:
WO2013033620A1 | 2013-03-07 | |||
WO2013030802A1 | 2013-03-07 | |||
WO2004089286A2 | 2004-10-21 | |||
WO2005019220A2 | 2005-03-03 | |||
WO2005080393A1 | 2005-09-01 | |||
WO2011090738A2 | 2011-07-28 | |||
WO2006038100A1 | 2006-04-13 |
Other References:
DATABASE REGISTRY [online] CAS; 13 February 2017 (2017-02-13), XP055835103, retrieved from STN Database accession no. RN 2069836-28-6
REVISED CLINICAL CLASSIFICATION OF PULMONARY HYPERTENSION, 2013
SMOLICH ET AL., BLOOD, vol. 97, pages 1413 - 1421
L. KUERTIB. CZAKO: "Strategic Applications of Named Reactions in Organic Synthesis", 2006, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
ORG. SYNTH., vol. 81, 2005, pages 63 - 76
R. C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY SONS, INC.
MARUZEN: "Experimental Chemistry", 1992, article "Chemical Society of Japan"
G. S. ZWEIFELM. H. NANTZ: "Modern Organic Synthesis: An Introduction", 2009, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
SONOGASHIRA ET AL., J, ORGANOMET. CHEM., vol. 653, 2002, pages 46 - 49
NEGISHI ET AL., CHEM. REV., vol. 103, 2003, pages 1979 - 2017
BUCHWALD ET AL., J. AM. CHEM. SOC., vol. 116, 1994, pages 7901 - 7902
BUCHWALD ET AL., ORG. SYNTH., vol. 78, 2002, pages 23 - 28
HARTWIG ET AL., ACC. CHEM. RES., vol. 41, 2008, pages 1534 - 1544
HECK ET AL., J. ORG. CHEM., vol. 37, 1972, pages 2320 - 2322
BELETSKAYA ET AL., CHEM. REV., vol. 100, 2000, pages 3009 - 3066
SUZUKI ET AL., CHEM. REV., vol. 95, 1995, pages 2457 - 2483
"Angew. Chem. Int. Ed.", vol. 50, 2011, pages: 8944 - 8947
CELL, vol. 77, 1994, pages 307 - 316
See also references of EP 4074376A4
REVISED CLINICAL CLASSIFICATION OF PULMONARY HYPERTENSION, 2013
SMOLICH ET AL., BLOOD, vol. 97, pages 1413 - 1421
L. KUERTIB. CZAKO: "Strategic Applications of Named Reactions in Organic Synthesis", 2006, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
ORG. SYNTH., vol. 81, 2005, pages 63 - 76
R. C. LAROCK: "Comprehensive Organic Transformations: A Guide to Functional Group Preparations", 1999, JOHN WILEY SONS, INC.
MARUZEN: "Experimental Chemistry", 1992, article "Chemical Society of Japan"
G. S. ZWEIFELM. H. NANTZ: "Modern Organic Synthesis: An Introduction", 2009, KAGAKU-DOJIN PUBLISHING COMPANY, INC.
SONOGASHIRA ET AL., J, ORGANOMET. CHEM., vol. 653, 2002, pages 46 - 49
NEGISHI ET AL., CHEM. REV., vol. 103, 2003, pages 1979 - 2017
BUCHWALD ET AL., J. AM. CHEM. SOC., vol. 116, 1994, pages 7901 - 7902
BUCHWALD ET AL., ORG. SYNTH., vol. 78, 2002, pages 23 - 28
HARTWIG ET AL., ACC. CHEM. RES., vol. 41, 2008, pages 1534 - 1544
HECK ET AL., J. ORG. CHEM., vol. 37, 1972, pages 2320 - 2322
BELETSKAYA ET AL., CHEM. REV., vol. 100, 2000, pages 3009 - 3066
SUZUKI ET AL., CHEM. REV., vol. 95, 1995, pages 2457 - 2483
"Angew. Chem. Int. Ed.", vol. 50, 2011, pages: 8944 - 8947
CELL, vol. 77, 1994, pages 307 - 316
See also references of EP 4074376A4
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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