Title:
COMPOUND FOR TREATING AUTOIMMUNE SKIN DISEASES CAUSED BY INFLAMMATION, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/221347
Kind Code:
A1
Abstract:
Disclosed are a compound for treating autoimmune skin diseases (for example, psoriasis) caused by inflammation, and a medicine and a pharmaceutical composition containing the compound, wherein the compound is Nib1, a pharmaceutically acceptable salt thereof, a solvate thereof, a solvate of the pharmaceutically acceptable salt thereof, or a crystal form thereof. The chemical formula of Nib1 is C28H29F2N3O. Also disclosed is a use of the compound, medicine and pharmaceutical composition in the preparation of a medicine for treating autoimmune skin diseases caused by inflammation, improving skin rash, improving skin peeling, reducing skin thickening, reducing epidermal hyperplasia, improving vasodilation and/or reducing immune cell infiltration. ![]()
Inventors:
FU XIN-YUAN (CN)
LUFEI CHENGCHEN (CN)
LIU XINYU (CN)
ZHOU YI (CN)
LUFEI CHENGCHEN (CN)
LIU XINYU (CN)
ZHOU YI (CN)
Application Number:
PCT/CN2020/088285
Publication Date:
November 05, 2020
Filing Date:
April 30, 2020
Export Citation:
Assignee:
GENEROS BIOPHARMA LTD (CN)
International Classes:
A61K31/454; A61P17/00; A61P17/06; A61P37/00
Foreign References:
| CN1294519A | 2001-05-09 | |||
| CN201910366891A | 2019-04-30 |
Other References:
YU PENG-JIU;WAN LI-MEI;XIE HUI: "Effect of STAT5 Pathway Inhibitor Pimozide on NO and iNOS Expressions in the Inflammation Model of RAW264.7 Cell", CHINA PHARMACY, vol. 26, no. 22, 10 August 2015 (2015-08-10), pages 3043 - 3045, XP055852968, ISSN: 1001-0408, DOI: 10.6039/j.issn.1001-0408.2015.22.06
LEVITE, M.: "Dopamine and T Cells: Dopamine Receptors and Potent Effects on T Cells, Dopamine Production in T Cells, and Abnormalities in the Dopaminergic System in T Cells in Autoimmune, Neurological and Psychiatric Diseases", ACTA PHYSIOLOGICA, vol. 216, no. 1, 31 January 2016 (2016-01-31), pages 42 - 89, XP055757802
JOURNAL OF NEUROLOGY, NEUROSURGERY, AND PSYCHIATRY, vol. 49, 1986, pages 791 - 795
"Pimozide in dermatologic practice", AM J CLIN DERMATOL, vol. 5, no. 5, 2004, pages 339 - 349
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
LEVITE, M.: "Dopamine and T Cells: Dopamine Receptors and Potent Effects on T Cells, Dopamine Production in T Cells, and Abnormalities in the Dopaminergic System in T Cells in Autoimmune, Neurological and Psychiatric Diseases", ACTA PHYSIOLOGICA, vol. 216, no. 1, 31 January 2016 (2016-01-31), pages 42 - 89, XP055757802
JOURNAL OF NEUROLOGY, NEUROSURGERY, AND PSYCHIATRY, vol. 49, 1986, pages 791 - 795
"Pimozide in dermatologic practice", AM J CLIN DERMATOL, vol. 5, no. 5, 2004, pages 339 - 349
BERGE ET AL.: "Pharmaceutical Salts", JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 66, 1977, pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
"Handbook of Pharmaceutical Salts: Properties, Selection, and Use", 2002, WILEY-VCH
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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