Title:
COMPOUND WITH INHIBITORY ACTIVITY AGAINST SIGMA2 AND 5HT2A AND USE
Document Type and Number:
WIPO Patent Application WO/2024/067304
Kind Code:
A1
Abstract:
The present invention provides a compound with inhibitory activity against Sigma2 and 5HT2A. The compound can be used as a dual-target inhibitor of Sigma2 and 5HT2A for the treatment of a related disease mediated by Sigma2 receptor activity, the treatment of a related disease mediated by 5HT2A receptor activity, and the treatment of a related disease mediated jointly by Sigma2 receptor activity and 5HT2A receptor activity, such as negative symptoms of schizophrenia.
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Inventors:
XING HONGTAO (CN)
Application Number:
PCT/CN2023/120119
Publication Date:
April 04, 2024
Filing Date:
September 20, 2023
Export Citation:
Assignee:
HAN YUAN MEDI PHARMA CO LTD (CN)
International Classes:
C07D211/58; A61K31/40; A61K31/445; A61K31/4468; A61P25/00; A61P25/18; C07D207/09; C07D211/26; C07D413/04; C07D451/06; C07D487/04
Domestic Patent References:
| WO2019040105A2 | 2019-02-28 | |||
| WO2022145408A1 | 2022-07-07 |
Foreign References:
| AU8564375A | 1977-04-21 | |||
| JPS5285174A | 1977-07-15 | |||
| CN113214141A | 2021-08-06 | |||
| CN1081677A | 1994-02-09 | |||
| CN109111385A | 2019-01-01 | |||
| CN111132976A | 2020-05-08 | |||
| CN1675201A | 2005-09-28 |
Other References:
DATABASE REGISTRY 24 February 2005 (2005-02-24), ANONYMOUS: "- Urea, N-[1-[2-(4-chlorophenyl)-2-oxoethyl]-4-piperidinyl]-N'-cyclohexyl- (CA INDEX NAME)", XP093156959, Database accession no. 836681-26-6
DATABASE REGISTRY 16 November 1984 (1984-11-16), ANONYMOUS: "- Urea, N-[1-[2-(4-fluorophenyl)-2-oxoethyl]-4-piperidinyl]-N,N'-diphenyl- (CA INDEX NAME)", XP093156960, Database accession no. 59629-22-0
DATABASE REGISTRY 16 November 1984 (1984-11-16), ANONYMOUS: "- Urea, N-[1-[2-(4-fluorophenyl)-2-oxoethyl]-4-piperidinyl]-N,N'-diphenyl- (CA INDEX NAME)", XP093156960, Database accession no. 59629-22-0
Attorney, Agent or Firm:
BEIJING YUNJIN IP LAW FIRM et al. (CN)
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